Kenneth Nilsson

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Part of Oncotarget, p. 103731-103743, 2017

• DOI for The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
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EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Part of Oncotarget, p. 10213-10224, 2017

• DOI for EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
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The Transcriptomic and Proteomic Landscapes of Bone Marrow and Secondary Lymphoid Tissues

Andersson, Sandra; Nilsson, Kenneth; Fagerberg, Linn; Hallstrom, Bjorn M. et al.

Part of PLOS ONE, 2014

• DOI for The Transcriptomic and Proteomic Landscapes of Bone Marrow and Secondary Lymphoid Tissues
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An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Alzrigat, Mohammad et al.

Part of Blood, 2014

Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia

Myhrinder, Anna Lanemo; Hellqvist, Eva; Bergh, Ann-Charlotte; Jansson, Mattias et al.

Part of Leukemia and Lymphoma, p. 1769-1779, 2013

• DOI for Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Part of Oncotarget, p. 103731-103743, 2017

• DOI for The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
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EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Part of Oncotarget, p. 10213-10224, 2017

• DOI for EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
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The Transcriptomic and Proteomic Landscapes of Bone Marrow and Secondary Lymphoid Tissues

Andersson, Sandra; Nilsson, Kenneth; Fagerberg, Linn; Hallstrom, Bjorn M. et al.

Part of PLOS ONE, 2014

• DOI for The Transcriptomic and Proteomic Landscapes of Bone Marrow and Secondary Lymphoid Tissues
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An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Alzrigat, Mohammad et al.

Part of Blood, 2014

Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia

Myhrinder, Anna Lanemo; Hellqvist, Eva; Bergh, Ann-Charlotte; Jansson, Mattias et al.

Part of Leukemia and Lymphoma, p. 1769-1779, 2013

• DOI for Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Part of BMC Cancer, p. 318, 2012

• DOI for Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
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Tumor-Initiating Cells in Childhood Neuroblastoma: Letter

Mohlin, Sofie; Pietras, Alexander; Wigerup, Caroline; Ora, Ingrid et al.

Part of Cancer Research, p. 821-822, 2012

• DOI for Tumor-Initiating Cells in Childhood Neuroblastoma: Letter

The novel NF-kappa B inhibitor IMD-0354 induces apoptosis in chronic lymphocytic leukemia

Kanduri, Meena; Tobin, Gerard; Åleskog, Anna; Nilsson, Kenneth et al.

Part of Blood Cancer Journal, 2011

• DOI for The novel NF-kappa B inhibitor IMD-0354 induces apoptosis in chronic lymphocytic leukemia

Large-Scale Protein Profiling in Human Cell Lines Using Antibody-Based Proteomics

Fagerberg, Linn; Strömberg, Sara; El-Obeid, Adila; Gry, Marcus et al.

Part of Journal of Proteome Research, p. 4066-4075, 2011

• DOI for Large-Scale Protein Profiling in Human Cell Lines Using Antibody-Based Proteomics

Polycomb target genes are silenced in multiple myeloma

Kalushkova, Antonia; Fryknäs, Mårten; Lemaire, Miguel; Fristedt, Charlotte et al.

Part of PLOS ONE, 2010

• DOI for Polycomb target genes are silenced in multiple myeloma
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Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Tshuikina, Marina; Jernberg-Wiklund, Helena; Nilsson, Kenneth; Öberg, Fredrik

Part of Experimental Hematology, p. 1673-1681, 2008

• DOI for Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene

Tshuikina, Marina; Nilsson, Kenneth; Öberg, Fredrik

Part of Gene, p. 259-267, 2008

• DOI for Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene

IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Kårehed, Karin; Dimberg, Anna; Dahl, Staffan; Nilsson, Kenneth et al.

Part of Molecular Immunology, p. 615-624, 2007

• DOI for IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival

Menu, Eline; Jernberg-Wiklund, Helena; De Raeve, Hendrik; De Leenheer, Evy et al.

Part of International Journal of Cancer, p. 1857-1861, 2007

• DOI for Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival

Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBP epsilon

Dimberg, Anna; Kårehed, Karin; Nilsson, Kenneth; Öberg, Fredrik

Part of Scandinavian Journal of Immunology, p. 271-279, 2006

• DOI for Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBP epsilon

IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.

Strömberg, Thomas; Ekman, Simon; Girnita, Leonard; Dimberg, Lina Y et al.

Part of Blood, p. 669-78, 2006

Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.

Menu, Eline; Jernberg-Wiklund, Helena; Stromberg, Thomas; De Raeve, Hendrik et al.

Part of Blood, p. 655-60, 2006

Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells

Dimberg, Lina; Dimberg, Anna; Ivarsson, Karolina; Strömberg, Thomas et al.

Part of Blood, p. 1346-1354, 2005

• DOI for Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells

Mcl-1 gene promoter insertions do not correlate with disease outcome, stage or V(H) gene mutation status in chronic lymphocytic leukaemia.

Tobin, Gerard; Skogsberg, Åsa; Thunberg, Ulf; Laurell, Anna et al.

Part of Leukemia, p. 871-873, 2005

Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.

Strömberg, Thomas; Dimberg, Anna; Hammarberg, Anna; Carlson, Kristina et al.

Part of Blood, p. 3138-47, 2004

Cytotoxic effect in vivo and in vitro of CHS 828 on human myeloma cell lines.

Hovstadius, Peter; Lindhagen, Elin; Hassan, Sadia; Nilsson, Kenneth et al.

Part of Anticancer Drugs, p. 63-70, 2004

Elevated levels of soluble CD44 are associated with advanced disease and in vitro proliferation of neoplastic lymphocytes in B-cell chronic lymphocytic leukemia

Eisterer, Wolfgang; Bechter, Oliver; Söderberg, Ola; Nilsson, Kenneth et al.

Part of Leukemia Res, p. 1043-1051, 2004

Differentiation-associated redox-regulation in human B cell lines from stemcell/pro-B to plasma cell

Nilssson, Joacim; Söderberg, Ola; Nilsson, Kenneth; Rosén, Anders

Part of Immunology Letters, p. 83-89, 2004

VH gene mutation status and cellular drug resistance in chronic lymphocytic leukemia

Åleskog, Anna; Tobin, Gerard; Laurell, Anna; Thunberg, Ulf et al.

Part of Eur J Haematol, p. 407-411, 2004

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguadine CHS 828

Gullbo, Joachim; Lövborg, Henrik; Dhar, Sumeer; Lukinius, Agneta et al.

Part of Anti-Cancer Drugs, p. 45-54, 2004

PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells

Tenno, Taavo; Öberg, Fredrik; Mackman, Nigel; Nilsson, Kenneth et al.

Part of Thrombosis and Haemostasis, p. 930-9, 2003

Expression of CCL5/RANTES by Hodgkin and Reed-Sternberg cells and its possible role in the recruitment of mast cells into lymphomatous tissue.

Fischer, Marie; Juremalm, Mikael; Olsson, Niclas; Backlin, Carin et al.

Part of Int J Cancer, p. 197-201, 2003

Ser727/Tyr701-phosphorylated Stat1 is required for the regulation ofc-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest ofU-937 cells.

Dimberg, A; Karlberg, I; Nilsson, K; Oberg, F

Part of Blood, p. 254, 2003

Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival.

Spets, Helena; Strömberg, Thomas; Georgii-Hemming, Patrik; Siljason, Jan et al.

Part of Eur J Haematol, p. 76-89, 2002

Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E andposttranscriptional up-regulation of p27(Kip1).

Dimberg, A; Bahram, F; Karlberg, I; Larsson, LG et al.

Part of Blood, p. 2199, 2002

Cytokine-induced restoration of differentiation and cell cycle arrest in v-Myc transformed U-937 monoblasts correlates with reduced Myc activity

Öberg, Fredrik; Wu, S.; Bahram, Fuad; Nilsson, Kenneth et al.

Part of Leukemia, p. 217-227, 2001

The role of RAR and RXR activation in retinoid-induced tissue factor suppression

Tenno, Taavo; Botling, Johan; Öberg, Fredrik; Jossan, S. et al.

Part of Leukemia, p. 1105-11, 2000

Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells

Nilsson, J; Söderberg, Ola; Nilsson, Kenneth; Rosén, A

Part of Blood, p. 1420-1426, 2000

Differences in the growth inhibition of cultured K-562 cells by selenium, mercury or cadmium in two tissue culture media (RPMI-1640, Ham's F-10).

Frisk, Peter; Yaqob, Amer; Nilsson, Kenneth; Carlsson, Jörgen et al.

Part of Biometals, p. 101-11, 2000

Phosphorylation-deficient Stat1 inhibits retinoic acid-induceddifferentiation and cell cycle arrest in U-937 monoblasts.

Dimberg, A; Nilsson, K; Oberg, F

Part of Blood, p. 2870, 2000

Induction of differentiation in U-937 and NB4 cells is associated with inhibition of tissue factor production

Tenno, Taavo; Öberg, Fredrik; Nilsson, Kenneth; Siegbahn, Agneta

Part of European Journal of Haematology, p. 112-119, 1999

Staphylococcus aureus Cowan strain 1 activation of B-chronic lymphocytic leukaemia cells augments the response to CD40 stimulation.

Söderberg, O; Thunberg, U; Weigelt, C; Christiansen, I et al.

Part of Scand J Immunol, p. 363-70, 1999

The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-dent and IL-6-independent human multiple myeloma cell lines.

Georgii-Hemming, P; Stromberg, T; Tiensuu Janson, E; Stridsberg, M et al.

Part of Blood, p. 1724, 1999

Fas/APO-1 (CD95)-mediated apoptosis is activated by interferon-gammanterleukin-6 (IL-6)-dependent and IL-6-independent multiple myeloma cell lines.

Spets, H; Georgii-Hemming, P; Siljason, J; Nilsson, K et al.

Part of Blood, p. 2914, 1998

Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation

Botling, Johan; Castro, Diogo S.; Öberg, Fredrik; Nilsson, Kenneth et al.

Part of Journal of Biological Chemistry, p. 9443-9, 1997

• DOI for Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation
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Tissue and differentiation specific expression of the endogenous retrovirus ERV3 (HERV-R) in normal human tissues and during induced monocytic differentiation in the U-937 cell line

Larsson, Erik; Venables, P.; Andersson, A-C.; Fan, W. et al.

Part of Leukemia, p. 142-4, 1997

Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/CD18)

Johansson, M; Patarroyo, M; Öberg, Fredrik; Siegbahn, Agneta et al.

Part of Journal of Cell Science, p. 1133-1139, 1997

Tissue factor expression in human monocytic cell lines

Tenno, Taavo; Botling, Johan; Öberg, Fredrik; Nilsson, Kenneth et al.

Part of Thrombosis Research, p. 215-28, 1997

Interleukin-15 + thioredoxin induce DNA synthesis in B-chronic lymphocytic leukemia cells but not in normal B cells.

Söderberg, O; Christiansen, I; Nilsson, G; Carlsson, M et al.

Part of Leukemia, p. 1298-304, 1997

The effects on growth and survival of IL-6 can be dissociated in the U-266-1970/U-266-1984 and HL407E/HL407L human multiple myeloma cell lines.

Spets, H; Jernberg-Wiklund, H; Sambade, C; Söderberg, O et al.

Part of Br J Haematol, p. 126-33, 1997

The effects on growth and survival of IL-6 can be dissociated in the U-266-1970/U-266-1984 and HL407E/HL407L human multiple myeloma cell lines.

Spets, H; Jernberg-Wiklund, H; Sambade, C; Soderberg, O et al.

Part of Br J Haematol, p. 126, 1997

CD40 ligation inhibits IL-2 and SAC+IL-2 induced proliferation in chronic lymphocytic leukaemia cells.

Söderberg, O; Christiansen, I; Carlsson, M; Nilsson, K

Part of Scand J Immunol, p. 706-14, 1997

Vitamin D3 and retinoic acid induced monocytic differentiation: Interactions between the endogenous vitamin D3, retinoic acid and retinoid X receptors in U-937 cells

Botling, Johan; Öberg, Fredrik; Törmä, Hans; Tuohimaa, Pentti et al.

Part of Cell growth & differentiation, p. 1239-49, 1996

Characterization of a human basophil-like cell line (LAMA-84)

Blom, T; Nilsson, G; Sundström, C; Nilsson, K et al.

Part of Scand. J. Immunol., p. 54-61, 1996

Stem cell factor-dependent human cord blood derived mast cells express alpha- and beta-tryptase, heparin and chondroitin sulphate

Nilsson, G; Blom, T; Harvima, I; Kusche-Gullberg, M et al.

Part of Immunology, p. 308-314, 1996

Expression of the endogenous retrovirus ERV3 (HERV-R) during induced monocytic differentiation in the U-937 cell line

Larsson, Erik; Venables, P.J.W.; Andersson, Ann-Catrin; Wansheng, F et al.

Part of Int. J. Cancer, p. 451, 1996

Insulin-like growth factor I is a growth- and survival factor in human multiple myeloma cell lines.

Georgii-Hemming, P; Jernberg-Wiklund, H; Ljunggren, Ö; Nilsson, K

Part of Blood, p. 2250, 1996

CD49f (alpha 6 integrin) and CD66a (BGP) are specifically induced by retinoids during human monocytic differentiation

Botling, Johan; Öberg, Fredrik; Nilsson, Kenneth

Part of Leukemia, p. 2034-41, 1995

Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma

Jernberg-Wiklund, Helena; Nilsson, Kenneth

Part of Upsala Journal of Medical Sciences, p. 166-177, 2012

• DOI for Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma

Control of Apoptosis in Human Multiple Myeloma by Insulin-like Growth Factor I (IGF-I)

Jernberg-Wiklund, Helena; Nilsson, Kenneth

Part of Advances in Cancer Research, p. 139-165, 2007

• DOI for Control of Apoptosis in Human Multiple Myeloma by Insulin-like Growth Factor I (IGF-I)

Plasma Cell and Myeloma Cell Lines

Jernberg Wiklund, Helena; Nilsson, Kenneth

Part of Human Cell Culture, Kluwer Academic Publishers, 2000

Stat1 involvement in retinoic acid induced differentiation of myeloid cells

Dimberg, Anna; Nilsson, Kenneth; Oberg, Fredrik

Part of Molecular mechanisms of signal transduction, p. 211, IOS press, Amsterdam, The Netherlands, 2000

Monocytes and Macrophages

Öberg, Fredrik; Nilsson, Kenneth

Part of Transplantation Biology, p. 241, Lippincott-Raven, 1996

Cytokine induced inhibition of Myc activity in monocytic cells

Larsson, Lars-Gunnar; Bahram, F.; Wu, S.; Öberg, Fredrik et al.

Part of C-myc in B-cell neoplasia, p. 191, 1997

The epigenomic map of multiple myeloma reveals the importance of Polycomb gene silencing for the malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Österborg, Anders et al.

Toward a rational combinaTORial therapy for multiple myeloma

Jernberg Wiklund, Helena; Nilsson, Kenneth

Part of Blood, p. 3845-3846, 2004

The control of proliferation, survival and apoptosis in human multiple myeloma cells in vitro

Nilsson, K; Georgii-Hemming, P; Spets, H; Jernberg-Wiklund, H

Part of MECHANISMS OF B CELL NEOPLASIA 1998, p. 325-333, 1999