Lars Rönnblom

Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases

Bianchi, Matteo; Kozyrev, Sergey V.; Notarnicola, Antonella; Sandling, Johanna K. et al.

Part of Arthritis & Rheumatology, p. 212-225, 2025

• DOI for Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases
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Rheumatoid Arthritis Related B-Cell Changes Are Found Already in the Risk-RA Phase

de Vries, Charlotte; Huang, Wenqi; Sharma, Ravi Kumar; Wangriatisak, Kittikorn et al.

Part of European Journal of Immunology, 2025

• DOI for Rheumatoid Arthritis Related B-Cell Changes Are Found Already in the Risk-RA Phase
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Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus

Stockfelt, Marit; Torell, Agnes; Gunnarsson, Iva; Svenungsson, Elisabet et al.

Part of Rheumatology, p. 1469-1475, 2024

• DOI for Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus
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The HLA region in ANCA-associated vasculitis: characterisation of genetic associations in a Scandinavian patient population

Lundtoft, Christian; Knight, Ann; Meadows, Jennifer; Karlsson, Åsa et al.

Part of RMD Open, 2024

• DOI for The HLA region in ANCA-associated vasculitis: characterisation of genetic associations in a Scandinavian patient population
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Arthritis progressors have a decreased frequency of circulating autoreactive T cells during the at-risk phase of rheumatoid arthritis

Turcinov, Sara; Sharma, Ravi Kumar; De Vries, Charlotte; Cîrciumaru, Alexandra et al.

Part of RMD Open, 2024

• DOI for Arthritis progressors have a decreased frequency of circulating autoreactive T cells during the at-risk phase of rheumatoid arthritis
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Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases

Bianchi, Matteo; Kozyrev, Sergey V.; Notarnicola, Antonella; Sandling, Johanna K. et al.

Part of Arthritis & Rheumatology, p. 212-225, 2025

• DOI for Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases
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Rheumatoid Arthritis Related B-Cell Changes Are Found Already in the Risk-RA Phase

de Vries, Charlotte; Huang, Wenqi; Sharma, Ravi Kumar; Wangriatisak, Kittikorn et al.

Part of European Journal of Immunology, 2025

• DOI for Rheumatoid Arthritis Related B-Cell Changes Are Found Already in the Risk-RA Phase
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Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus

Stockfelt, Marit; Torell, Agnes; Gunnarsson, Iva; Svenungsson, Elisabet et al.

Part of Rheumatology, p. 1469-1475, 2024

• DOI for Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus
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The HLA region in ANCA-associated vasculitis: characterisation of genetic associations in a Scandinavian patient population

Lundtoft, Christian; Knight, Ann; Meadows, Jennifer; Karlsson, Åsa et al.

Part of RMD Open, 2024

• DOI for The HLA region in ANCA-associated vasculitis: characterisation of genetic associations in a Scandinavian patient population
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Arthritis progressors have a decreased frequency of circulating autoreactive T cells during the at-risk phase of rheumatoid arthritis

Turcinov, Sara; Sharma, Ravi Kumar; De Vries, Charlotte; Cîrciumaru, Alexandra et al.

Part of RMD Open, 2024

• DOI for Arthritis progressors have a decreased frequency of circulating autoreactive T cells during the at-risk phase of rheumatoid arthritis
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A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile

Lindelöf, Linnea; Rantapää-Dahlqvist, Solbritt; Lundtoft, Christian; Sandling, Johanna K. et al.

Part of Journal of Autoimmunity, 2024

• DOI for A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile
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Low CD4+T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy

Torell, Agnes; Stockfelt, Marit; Blennow, Kaj; Zetterberg, Henrik et al.

Part of Arthritis Research & Therapy, 2024

• DOI for Low CD4+T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy
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Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies

Leclair, Valerie; Galindo-Feria, Angeles S.; Rothwell, Simon; Krystufkova, Olga et al.

Part of EBioMedicine, 2023

• DOI for Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies
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Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus

Torell, Agnes; Stockfelt, Marit; Larsson, Gunilla; Blennow, Kaj et al.

Part of Arthritis Research & Therapy, 2023

• DOI for Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
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2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice

Rodriguez-Carrio, Javier; Burska, Agata; Conaghan, Philip G.; Dik, Willem A. et al.

Part of Annals of the Rheumatic Diseases, p. 754-762, 2023

• DOI for 2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice

Relation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison's disease

Lundtoft, Christian; Eriksson, Daniel; Bianchi, Matteo; Aranda-Guillen, Maribel et al.

Part of European Journal of Endocrinology, p. 235-241, 2023

• DOI for Relation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison's disease
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Stratified genetic analysis reveals sex differences in MPO-ANCA-associated vasculitis

Ekman, Diana; Sennblad, Bengt; Knight, Ann; Karlsson, Åsa et al.

Part of Rheumatology, p. 3213-3218, 2023

• DOI for Stratified genetic analysis reveals sex differences in MPO-ANCA-associated vasculitis
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Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease

Yavuz, Sule; Pucholt, Pascal; Sandling, Johanna K.; Bianchi, Matteo et al.

Part of Lupus Science and Medicine, 2022

• DOI for Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease
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Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA-DRB1 Genotype Associations and Immunological and Clinical Manifestations

Diaz-Gallo, Lina-Marcela; Oke, Vilija; Lundström, Emeli; Elvin, Kerstin et al.

Part of ACR Open Rheumatology, p. 27-39, 2022

• DOI for Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA-DRB1 Genotype Associations and Immunological and Clinical Manifestations
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Contribution of rare genetic variation to disease susceptibility in a large Scandinavian myositis cohort

Bianchi, Matteo; Kozyrev, Sergey V.; Notarnicola, Antonella; Hultin-Rosenberg, Lina et al.

Part of Arthritis & Rheumatology, p. 342-352, 2022

• DOI for Contribution of rare genetic variation to disease susceptibility in a large Scandinavian myositis cohort
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Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases

Lundtoft, Christian; Pucholt, Pascal; Martin, Myriam; Bianchi, Matteo et al.

Part of Arthritis & Rheumatology, p. 1440-1450, 2022

• DOI for Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
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Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome

Lundtoft, Christian; Sjöwall, Christopher; Rantapää‐Dahlqvist, Solbritt; Bengtsson, Anders A. et al.

Part of Arthritis & Rheumatology, p. 1842-1850, 2022

• DOI for Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome
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Genome-wide association study identifies Sjogren's risk loci with functional implications in immune and glandular cells

Khatri, Bhuwan; Tessneer, Kandice L.; Rasmussen, Astrid; Aghakhanian, Farhang et al.

Part of Nature Communications, 2022

• DOI for Genome-wide association study identifies Sjogren's risk loci with functional implications in immune and glandular cells
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Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma

Nilsson, Magnus; Rhedin, Magdalena; Hendrickx, Ramon; Berglund, Susanne et al.

Part of Drug Design, Development and Therapy, p. 2901-2917, 2022

• DOI for Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma
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Five commercially-available antibodies react differentially with allelic forms of human HLA-DR beta chain

Houtman, Miranda; Dzebisashvili, Anna; Dubnovitsky, Anatoly; Kozhukh, Genadiy et al.

Part of Molecular Immunology, p. 106-110, 2022

• DOI for Five commercially-available antibodies react differentially with allelic forms of human HLA-DR beta chain
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Variants in BANK1 are associated with lupus nephritis of European ancestry.

Bolin, Karin; Imgenberg-Kreuz, Juliana; Leonard, Dag; Sandling, Johanna K. et al.

Part of Genes and Immunity, p. 194-202, 2021

• DOI for Variants in BANK1 are associated with lupus nephritis of European ancestry.
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Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome

Thorlacius, Guðný Ella; Hultin-Rosenberg, Lina; Sandling, Johanna K.; Bianchi, Matteo et al.

Part of Rheumatology, p. 837-848, 2021

• DOI for Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome
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Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing

Sandling, Johanna K.; Pucholt, Pascal; Hultin-Rosenberg, Lina; Farias, Fabiana H. G. et al.

Part of Annals of the Rheumatic Diseases, p. 109-117, 2021

• DOI for Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
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Comparison of Surrogate Markers of the Type I Interferon Response and Their Ability to Mirror Disease Activity in Systemic Lupus Erythematosus

Enocsson, Helena; Wetterö, Jonas; Eloranta, Maija-Leena; Gullstrand, Birgitta et al.

Part of Frontiers in Immunology, 2021

• DOI for Comparison of Surrogate Markers of the Type I Interferon Response and Their Ability to Mirror Disease Activity in Systemic Lupus Erythematosus
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Contributions of de novo variants to systemic lupus erythematosus

Carlsson Almlöf, Jonas; Nystedt, Sara; Mechtidou, Aikaterini; Leonard, Dag et al.

Part of European Journal of Human Genetics, p. 184-193, 2021

• DOI for Contributions of de novo variants to systemic lupus erythematosus
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NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE

Georgakis, Spiros; Gkirtzimanaki, Katerina; Papadaki, Garyfalia; Gakiopoulou, Hariklia et al.

Part of JCI Insight, 2021

• DOI for NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE
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De novo lupus nephritis during treatment with belimumab

Parodis, Ioannis; Vital, Edward M.; Hassan, Sabih-Ul; Jönsen, Andreas et al.

Part of Rheumatology, p. 4348-4354, 2021

• DOI for De novo lupus nephritis during treatment with belimumab
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DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome

Imgenberg-Kreuz, Juliana; Sandling, Johanna K.; Norheim, Katrine Braekke; Johnsen, Svein Joar Auglaend et al.

Part of Frontiers in Immunology, 2021

• DOI for DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome
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Interaction between the STAT4rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus

Reid, Sarah; Hagberg, Niklas; Sandling, Johanna K.; Alexsson, Andrei et al.

Part of Annals of the Rheumatic Diseases, p. 1183-1189, 2021

• DOI for Interaction between the STAT4rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus
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Genetic variants at the RTP4/MASP1 locus are associated with fatigue in Scandinavian patients with primary Sjogren's syndrome

Norheim, Katrine Braekke; Imgenberg-Kreuz, Juliana; Alexsson, Andrei; Johnsen, Svein Joar Auglaend et al.

Part of RMD Open, 2021

• DOI for Genetic variants at the RTP4/MASP1 locus are associated with fatigue in Scandinavian patients with primary Sjogren's syndrome
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C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205

Enocsson, Helena; Gullstrand, Birgitta; Eloranta, Maija-Leena; Wetterö, Jonas et al.

Part of Frontiers in Immunology, 2021

• DOI for C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
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Toll-like receptors revisited: a possible role for TLR1 in lupus nephritis

Yavuz, Sule; Bianchi, Matteo; Kozyrev, Sergey; Bolin, Karin et al.

Part of Annals of the Rheumatic Diseases, p. 404-406, 2021

• DOI for Toll-like receptors revisited: a possible role for TLR1 in lupus nephritis
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Association of Protective HLA-A With HLA-B∗27 Positive Ankylosing Spondylitis

Nordin, Jessika; Pettersson, Mats; Hultin Rosenberg, Lina; Mathioudaki, Argyri et al.

Part of Frontiers in Genetics, 2021

• DOI for Association of Protective HLA-A With HLA-B∗27 Positive Ankylosing Spondylitis
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Identification and Functional Characterization of a Novel Susceptibility Locus for Small Vessel Vasculitis with MPO-ANCA

Dahlqvist, Johanna; Ekman, Diana; Sennblad, Bengt; Kozyrev, Sergey V. et al.

Part of Rheumatology, p. 3461-3470, 2021

• DOI for Identification and Functional Characterization of a Novel Susceptibility Locus for Small Vessel Vasculitis with MPO-ANCA
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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Gaziano, Liam; Giambartolomei, Claudia; Pereira, Alexandre C.; Gaulton, Anna et al.

Part of Nature Medicine, 2021

• DOI for Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Haplotype-Specific Expression Analysis of MHC Class II Genes in Healthy Individuals and Rheumatoid Arthritis Patients

Houtman, Miranda; Hesselberg, Espen; Rönnblom, Lars; Klareskog, Lars et al.

Part of Frontiers in Immunology, 2021

• DOI for Haplotype-Specific Expression Analysis of MHC Class II Genes in Healthy Individuals and Rheumatoid Arthritis Patients
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Biomarkers: to be or not to be

Yavuz, Sule; Rönnblom, Lars

Part of Annals of the Rheumatic Diseases, 2020

• DOI for Biomarkers: to be or not to be

Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero

Hedlund, Malin; Thorlacius, Gudny Ella; Ivanchenko, Margarita; Ottosson, Vijole et al.

Part of RMD Open, 2020

• DOI for Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero
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Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS: Evaluation of whole blood, plasma and serum as sample matrices

Carlsson, Henrik; Hjorton, Karin; Abujrais, Sandy; Rönnblom, Lars et al.

Part of Arthritis Research & Therapy, 2020

• DOI for Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS: Evaluation of whole blood, plasma and serum as sample matrices
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The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells

Hjorton, Karin; Hagberg, Niklas; Pucholt, Pascal; Eloranta, Maija-Leena et al.

Part of Arthritis Research & Therapy, 2020

• DOI for The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells
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Proinflammatory Histidyl-Transfer RNA Synthetase-Specific CD4+T Cells in the Blood and Lungs of Patients With Idiopathic Inflammatory Myopathies

Galindo-Feria, Angeles S.; Albrecht, Inka; Fernandes-Cerqueira, Catia; Notarnicola, Antonella et al.

Part of Arthritis & Rheumatology, p. 179-191, 2020

• DOI for Proinflammatory Histidyl-Transfer RNA Synthetase-Specific CD4+T Cells in the Blood and Lungs of Patients With Idiopathic Inflammatory Myopathies

Activation of plasmacytoid dendritic cells and B cells with two structurally different Toll-like receptor 7 agonists

Berggren, Olof; Pucholt, Pascal; Amcoff, Cane; Rönnblom, Lars et al.

Part of Scandinavian Journal of Immunology, 2020

• DOI for Activation of plasmacytoid dendritic cells and B cells with two structurally different Toll-like receptor 7 agonists
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Learning from similarities between vaccine responses and SLE

Wahren-Herlenius, Marie; Rönnblom, Lars

Part of Nature Reviews Rheumatology, p. 355-356, 2020

• DOI for Learning from similarities between vaccine responses and SLE

Immunogenetics in systemic lupus erythematosus: Transitioning from genetic associations to cellular effects

Hagberg, Niklas; Lundtoft, Christian; Rönnblom, Lars

Part of Scandinavian Journal of Immunology, 2020

• DOI for Immunogenetics in systemic lupus erythematosus: Transitioning from genetic associations to cellular effects
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Population-based study of patients with primary Sjögren's syndrome and lymphoma: lymphoma subtypes, clinical characteristics, and gender differences

Vasaitis, Lilian; Nordmark, Gunnel; Theander, E; Backlin, Carin et al.

Part of Scandinavian Journal of Rheumatology, p. 225-232, 2020

• DOI for Population-based study of patients with primary Sjögren's syndrome and lymphoma: lymphoma subtypes, clinical characteristics, and gender differences

Lymphopenia as a risk factor for neurologic involvement and organ damage accrual in patients with systemic lupus erythematosus: A multi-center observational study

Yavuz, Sule; Cansu, Dondu U.; Nikolopoulos, Dionysis; Crisafulli, Francesca et al.

Part of Seminars in Arthritis & Rheumatism, p. 1387-1393, 2020

• DOI for Lymphopenia as a risk factor for neurologic involvement and organ damage accrual in patients with systemic lupus erythematosus: A multi-center observational study

High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

Reid, Sarah; Alexsson, Andrei; Frodlund, Martina; Morris, David et al.

Part of Annals of the Rheumatic Diseases, p. 363-369, 2020

• DOI for High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
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NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus

Linge, Petrus; Arve, Sabine; Olsson, Lina M.; Leonard, Dag et al.

Part of Annals of the Rheumatic Diseases, p. 254-261, 2020

• DOI for NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

Lundtoft, Christian; Pucholt, Pascal; Imgenberg-Kreuz, Juliana; Carlsson Almlöf, Jonas et al.

Part of PLOS Genetics, 2020

• DOI for Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling
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Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis

Gerstner, Christina; Turcinov, Sara; Hensvold, Aase H.; Chemin, Karine et al.

Part of BMC Immunology, 2020

• DOI for Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis
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Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.

Idborg, Helena; Zandian, Arash; Ossipova, Elena; Wigren, Edvard et al.

Part of Frontiers in Immunology, 2019

• DOI for Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
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Sex differences in clinical presentation of systemic lupus erythematosus

Ramírez Sepúlveda, Jorge I; Bolin, Karin; Mofors, Johannes; Leonard, Dag et al.

Part of Biology of Sex Differences, 2019

• DOI for Sex differences in clinical presentation of systemic lupus erythematosus
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Interferon-α enhances the IL-12-induced STAT4 activation selectively in carriers of the STAT4 SLE risk allele rs7574865[T]

Hagberg, Niklas; Rönnblom, Lars

Part of Annals of the Rheumatic Diseases, p. 429-431, 2019

• DOI for Interferon-α enhances the IL-12-induced STAT4 activation selectively in carriers of the STAT4 SLE risk allele rs7574865[T]
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Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus

Almlöf, Jonas Carlsson; Nystedt, Sara; Leonard, Dag; Eloranta, Maija-Leena et al.

Part of Human Genetics, p. 141-150, 2019

• DOI for Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
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Comparison of patients with and without pre-existing lymphoma at diagnosis of primary Sjögren's syndrome

Vasaitis, Lilian; Nordmark, Gunnel; Theander, E; Backlin, Carin et al.

Part of Scandinavian Journal of Rheumatology, p. 207-212, 2019

• DOI for Comparison of patients with and without pre-existing lymphoma at diagnosis of primary Sjögren's syndrome
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A case of systemic lupus erythematosus with C1q deficiency, increased serum interferon-a levels and high serum interferogenic activity

Bolin, Karin; Eloranta, Maija-Leena; Kozyrev, Sergey V.; Dahlqvist, Johanna et al.

Part of Rheumatology, p. 918-919, 2019

• DOI for A case of systemic lupus erythematosus with C1q deficiency, increased serum interferon-a levels and high serum interferogenic activity

Shared and Unique Patterns of DNA Methylation in Systemic Lupus Erythematosus and Primary Sjogren's Syndrome

Imgenberg-Kreuz, Juliana; Carlsson Almlöf, Jonas; Leonard, Dag; Sjöwall, Christopher et al.

Part of Frontiers in Immunology, 2019

• DOI for Shared and Unique Patterns of DNA Methylation in Systemic Lupus Erythematosus and Primary Sjogren's Syndrome
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Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

Odqvist, Lina; Jevnikar, Zala; Riise, Rebecca; Oberg, Lisa et al.

Part of Annals of the Rheumatic Diseases, p. 1363-1370, 2019

• DOI for Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus
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Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases

Weissenberg, Sarah Y.; Szelinski, Franziska; Schrezenmeier, Eva; Stefanski, Ana-Luisa et al.

Part of Frontiers in Immunology, 2019

• DOI for Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases
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A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts

Farias, Fabiana H. G.; Dahlqvist, Johanna; Kozyrev, Sergey V.; Leonard, Dag et al.

Part of European Journal of Human Genetics, p. 432-441, 2019

• DOI for A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts
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Exploring rare and low-frequency variants in the Saguenay-Lac-Saint-Jean population identified genes associated with asthma and allergy traits

Morin, Andreanne; Madore, Anne-Marie; Kwan, Tony; Ban, Maria et al.

Part of European Journal of Human Genetics, p. 90-101, 2019

• DOI for Exploring rare and low-frequency variants in the Saguenay-Lac-Saint-Jean population identified genes associated with asthma and allergy traits
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Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements

Allum, Fiona; Hedman, Asa K.; Shaol, Xiaojian; Cheung, Warren A. et al.

Part of Nature Communications, 2019

• DOI for Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements
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IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis

Lindahl, Hannes; Guerreiro-Cacais, Andre O.; Bedri, Sahl Khalid; Linnerbauer, Mathias et al.

Part of Journal of Immunology, p. 888-898, 2019

• DOI for IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis

Shared and unique patterns of DNA methylation in primary Sjogren's syndrome and systemic lupus erythematosus

Imgenberg-Kreuz, Juliana; Leonard, Dag; Carlsson Almlöf, Jonas; Rantapaa-Dahlqvist, S. et al.

Part of Scandinavian Journal of Rheumatology, p. 3-3, 2018

Genetic basis and clinical evidence for two variants of primary Sjögren's syndrome with distinct outcomes

Thorlacius, Gudny Ella; Hultin-Rosenberg, Lina; Sandling, Johanna K.; Imgenberg-Kreuz, Juliana et al.

Part of Clinical and Experimental Rheumatology, 2018

Interleukin-22 and associated genes are targets of microRNAs dysregulated

Tarn, Jessica R.; Nordmark, Gunnel; Gillespie, Colin; Al-Ali, Shereen et al.

Part of Clinical and Experimental Rheumatology, 2018

Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis

Leonard, Dag; Svenungsson, Elisabet; Dahlqvist, Johanna; Alexsson, Andrei et al.

Part of Annals of the Rheumatic Diseases, p. 1063-1069, 2018

• DOI for Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis
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The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE

Hagberg, Niklas; Joelsson, Martin; Leonard, Dag; Reid, Sarah et al.

Part of Annals of the Rheumatic Diseases, p. 1070-1077, 2018

• DOI for The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
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EOMES-positive CD4+ T cells are increased in PTPN22 (1858T) risk allele carriers.

Chemin, Karine; Ramsköld, Daniel; Diaz-Gallo, Lina-Marcela; Herrath, Jessica et al.

Part of European Journal of Immunology, p. 655-669, 2018

• DOI for EOMES-positive CD4+ T cells are increased in PTPN22 (1858T) risk allele carriers.

T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus

Houtman, Miranda; Shchetynsky, Klementy; Chemin, Karine; Hensvold, Aase Haj et al.

Part of Journal of Autoimmunity, p. 28-38, 2018

• DOI for T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus
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Transcription profiling of peripheral B cells in antibody-positive primary Sjogren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature

Imgenberg-Kreuz, Juliana; Sandling, Johanna K.; Bjork, A.; Nordlund, J. et al.

Part of Scandinavian Journal of Immunology, 2018

• DOI for Transcription profiling of peripheral B cells in antibody-positive primary Sjogren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature
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DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus

Imgenberg-Kreuz, Juliana; Almlöf, Jonas Carlsson; Leonard, Dag; Alexsson, Andrei et al.

Part of Annals of the Rheumatic Diseases, p. 736-743, 2018

• DOI for DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus
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Cytokine production by activated plasmacytoid dendritic cells and NK cells is suppressed by an IRAK4 inhibitor

Hjorton, Karin; Hagberg, Niklas; Israelsson, E.; Berggren, Olof et al.

Part of Annals of the Rheumatic Diseases, p. 1268-1269, 2018

• DOI for Cytokine production by activated plasmacytoid dendritic cells and NK cells is suppressed by an IRAK4 inhibitor

The value of type i interferon signature to stratify patients

Rönnblom, Lars

Part of Annals of the Rheumatic Diseases, p. 46-46, 2018

• DOI for The value of type i interferon signature to stratify patients

Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Hjorton, Karin; Hagberg, Niklas; Israelsson, Elisabeth; Jinton, Lisa et al.

Part of Arthritis Research & Therapy, 2018

• DOI for Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor
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Functional characterization of the Sjögren's syndrome-associated locus DDX6-CXCR5

Khanam, Sharmily; Joachims, Michelle L.; Means, Nicholas; Adrianto, Indra et al.

Part of Clinical and Experimental Rheumatology, 2018

ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease

Bremer, Hanna D.; Landegren, Nils; Sjöberg, Ronald; Hallgren, Åsa et al.

Part of Scientific Reports, 2018

• DOI for ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
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Common genetic variation in the autoimmune regulator (AIRE) locus is associated with autoimmune Addison's disease in Sweden

Eriksson, Daniel; Bianchi, Matteo; Landegren, Nils; Dalin, Frida et al.

Part of Scientific Reports, 2018

• DOI for Common genetic variation in the autoimmune regulator (AIRE) locus is associated with autoimmune Addison's disease in Sweden
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Memory T cells specific to citrullinated alpha-enolase are enriched in the rheumatic joint

Pieper, Jennifer; Dubnovitsky, Anatoly; Gerstner, Christina; James, Eddie A. et al.

Part of Journal of Autoimmunity, p. 47-56, 2018

• DOI for Memory T cells specific to citrullinated alpha-enolase are enriched in the rheumatic joint

Type I IFN System Activation In Newborns Exposed To Anti-Ro/Ssa Autoantibodies In Utero

Hedlund, Malin; Thorlacius, Gudny Ella; Ivanchenko, Margarita; Kyriakidis, Nikolaos et al.

Part of Annals of the Rheumatic Diseases, 2017

• DOI for Type I IFN System Activation In Newborns Exposed To Anti-Ro/Ssa Autoantibodies In Utero

SLE Comprises Four Immune-Phenotypes, Which Differ Regarding HLA-DRB1 and Clinical Associations

Gallo, Lina Marcela Diaz; Lundstrom, Emeli; Oke, Vilija; Elvin, Kerstin et al.

Part of Arthritis & Rheumatology, 2017

Genetic Determinants of Fatigue in Primary Sjogren's Syndrome: a Genome Wide Association Study

Norheim, Katrine; Alexsson, Andrei; Imgenberg-Kreuz, Juliana; Brun, Johan Gorgas et al.

Part of Arthritis & Rheumatology, 2017

Difference in Clinical Presentation between Female and Male Patients with Primary Sjogren's Syndrome at Diagnosis and in Long-Term Follow-up

Ramirez, Jorge; Kvarnstrom, Marika; Brauner, Susanna; Baldini, Chiara et al.

Part of Arthritis & Rheumatology, 2017

Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus

Imgenberg-Kreuz, Juliana; Almlöf, Jonas Carlsson; Leonard, Dag; Nordmark, Gunnel et al.

Part of Arthritis & Rheumatology, 2017

High Genetic Risk Score Is Associated with Increased Organ Damage in SLE

Reid, Sarah; Alexsson, Andrei; Frodlund, Martina; Sandling, Johanna K. et al.

Part of Arthritis & Rheumatology, 2017

Type I Interferon System In Autoimmunity

Rönnblom, Lars

Part of Annals of the Rheumatic Diseases, p. 11-11, 2017

• DOI for Type I Interferon System In Autoimmunity

Type I IFN System Activation In Newborns Exposed To ANTI-RO/SSA Autoantibodies In Utero

Wahren, M.; Hedlund, M.; Thorlacius, G. E.; Ivanchenko, M. et al.

Part of Annals of the Rheumatic Diseases, p. 182-182, 2017

• DOI for Type I IFN System Activation In Newborns Exposed To ANTI-RO/SSA Autoantibodies In Utero

Novel risk genes for systemic lupus erythematosus predicted by random forest classification

Carlsson Almlöf, Jonas; Alexsson, Andrei; Imgenberg-Kreuz, Juliana; Sylwan, Lina et al.

Part of Scientific Reports, 2017

• DOI for Novel risk genes for systemic lupus erythematosus predicted by random forest classification
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Role of interferons in SLE

Bengtsson, Anders A.; Rönnblom, Lars

Part of Baillière's Best Practice & Research, p. 415-428, 2017

• DOI for Role of interferons in SLE

A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus

Olsson, Lina M.; Johansson, Asa C.; Gullstrand, Birgitta; Jonsen, Andreas et al.

Part of Annals of the Rheumatic Diseases, p. 1607-1613, 2017

• DOI for A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus

Interferon-α coincides with suppressed levels of pentraxin-3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 in vitro

Wirestam, Lina; Enocsson, Helena; Skogh, Thomas; Eloranta, Maija-Leena et al.

Part of Clinical and Experimental Immunology, p. 83-91, 2017

• DOI for Interferon-α coincides with suppressed levels of pentraxin-3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 in vitro

Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero

Thorlacius, Gudny Ella; Hedlund, Malin; Ivanchenko, Margarita; Ottosson, Vijole et al.

Part of Arthritis & Rheumatology, 2017

Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients

Sepulveda, Jorge I. Ramirez; Kvarnstrom, Marika; Eriksson, Per; Mandl, Thomas et al.

Part of Biology of Sex Differences, 2017

• DOI for Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients
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Transancestral mapping and genetic load in systemic lupus erythematosus

Langefeld, Carl D.; Ainsworth, Hannah C.; Graham, Deborah S. Cunninghame; Kelly, Jennifer A. et al.

Part of Nature Communications, 2017

• DOI for Transancestral mapping and genetic load in systemic lupus erythematosus
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Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

Li, He; Reksten, Tove Ragna; Ice, John A.; Kelly, Jennifer A. et al.

Part of PLOS Genetics, 2017

• DOI for Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons
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Plasmacytoid dendritic cells and RNA-containing immune complexes drive expansion of peripheral B cell subsets with an SLE-like phenotype

Berggren, Olof; Hagberg, Niklas; Alexsson, Andrei; Weber, Gert et al.

Part of PLOS ONE, 2017

• DOI for Plasmacytoid dendritic cells and RNA-containing immune complexes drive expansion of peripheral B cell subsets with an SLE-like phenotype
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Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1

Smith-Anttila, Casey J. A.; Bensing, Sophie; Alimohammadi, Mohammad; Dalin, Frida et al.

Part of Autoimmunity, p. 223-231, 2017

• DOI for Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1

Identification of a novel pro-inflammatory T cell epitope from his-tRNA-synthetase associated with interstitial lung disease in anti-Jo-1 positive patients

Galindo-Feria, Angeles Shunashy; Albrecht, Inka; Notarnicola, Antonella; Dastmalchi, Maryam et al.

Part of Scandinavian Journal of Immunology, p. 317-317, 2017

Activated Plasmacytoid Dendritic Cells (PDCS) Alter The Composition of The Blood B Cell Subsets

Berggren, Olof; Rönnblom, Lars; Eloranta, Maija-Leena

Part of Annals of the Rheumatic Diseases, p. 179-179, 2016

• DOI for Activated Plasmacytoid Dendritic Cells (PDCS) Alter The Composition of The Blood B Cell Subsets

The Effect of Hydroxychloroquine and IRAK4 Inhibition on The IFN-A and TNF-A Production Induced by Sle Related Immune Complexes

Hjorton, Karin; Hagberg, Niklas; Berggren, Olof; Mo, J. et al.

Part of Annals of the Rheumatic Diseases, p. 277-277, 2016

• DOI for The Effect of Hydroxychloroquine and IRAK4 Inhibition on The IFN-A and TNF-A Production Induced by Sle Related Immune Complexes

The Interferon Pathway in Sle: from Immunology To New Insights and New Treatment

Rönnblom, Lars

Part of Annals of the Rheumatic Diseases, p. 40-41, 2016

• DOI for The Interferon Pathway in Sle: from Immunology To New Insights and New Treatment

Identification of Sjögren's Syndrome Risk Loci near TNFAIP3 and PRDM1

Lessard, C.; Li, H.; Ice, J. A.; Adrianto, I. et al.

Part of Annals of the Rheumatic Diseases, p. 664-664, 2016

• DOI for Identification of Sjögren's Syndrome Risk Loci near TNFAIP3 and PRDM1

Targeting The Type I Interferon System In SLE

Rönnblom, Lars

Part of Clinical and Experimental Rheumatology, 2016

A Novel HLA-DRB1*10:01-Restricted T Cell Epitope From Citrullinated Type II Collagen Relevant to Rheumatoid Arthritis

Chemin, Karine; Pollastro, Sabrina; James, Eddie; Ge, Changrong et al.

Part of Arthritis & Rheumatology, p. 1124-1135, 2016

• DOI for A Novel HLA-DRB1*10:01-Restricted T Cell Epitope From Citrullinated Type II Collagen Relevant to Rheumatoid Arthritis

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

Morris, David L; Sheng, Yujun; Zhang, Yan; Wang, Yong-Fei et al.

Part of Nature Genetics, 2016

• DOI for Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

Cause and consequences of the activated type I interferon system in SLE

Eloranta, Maija-Leena; Rönnblom, Lars

Part of Journal of Molecular Medicine, p. 1103-1110, 2016

• DOI for Cause and consequences of the activated type I interferon system in SLE
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The effect of PTPN22 Gene Variant R620W on the Type I Interferon Production Stimulated by Different TLR7 Agonists: Comment on Article by Wang et al (pages 2403-2414)

Berggren, Olof; Rönnblom, Lars; Eloranta, Maija-Leena

Part of Arthritis & Rheumatology, p. 1045-1045, 2016

• DOI for The effect of PTPN22 Gene Variant R620W on the Type I Interferon Production Stimulated by Different TLR7 Agonists: Comment on Article by Wang et al (pages 2403-2414)

The importance of the type I interferon system in autoimmunity

Rönnblom, Lars

Part of Clinical and Experimental Rheumatology, 2016

Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study.

Folkersen, Lasse; Brynedal, Boel; Diaz-Gallo, Lina Marcela; Ramsköld, Daniel et al.

Part of Molecular Medicine, p. 322-328, 2016

• DOI for Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study.
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Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes

Imgenberg-Kreuz, Juliana; Sandling, Johanna K.; Almlöf, Jonas Carlsson; Nordlund, Jessica et al.

Part of Annals of the Rheumatic Diseases, p. 2029-2036, 2016

• DOI for Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes
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Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes

Leonard, Dag; Eloranta, Maija-Leena; Hagberg, Niklas; Berggren, Olof et al.

Part of Annals of the Rheumatic Diseases, p. 1728-1734, 2016

• DOI for Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes

Case definitions in Swedish register data to identify systemic lupus erythematosus

Arkema, Elizabeth V; Jönsen, Andreas; Rönnblom, Lars; Svenungsson, Elisabet et al.

Part of BMJ Open, 2016

• DOI for Case definitions in Swedish register data to identify systemic lupus erythematosus
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DNA methylome analysis of acute lymphoblastic leukemia cells reveals stochastic de novo DNA methylation in CpG islands

Wahlberg, Per; Lundmark, Anders; Nordlund, Jessica; Busche, Stephan et al.

Part of Epigenomics, p. 1367-1387, 2016

• DOI for DNA methylome analysis of acute lymphoblastic leukemia cells reveals stochastic de novo DNA methylation in CpG islands
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Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells

Morin, Andreanne; Kwan, Tony; Ge, Bing; Letourneau, Louis et al.

Part of BMC Medical Genomics, 2016

• DOI for Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells
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Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression

Cavalli, Marco; Pan, Gang; Nord, Helena; Wallerman, Ola et al.

Part of Human Genetics, p. 485-497, 2016

• DOI for Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression
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Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted alpha-Enolase T Cell Epitope in Rheumatoid Arthritis

Gerstner, Christina; Dubnovitsky, Anatoly; Sandin, Charlotta; Kozhukh, Genadiy et al.

Part of Frontiers in Immunology, 2016

• DOI for Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted alpha-Enolase T Cell Epitope in Rheumatoid Arthritis
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Extended exome sequencing identifies BACH2 as a novel major risk locus for Addison's disease

Eriksson, D.; Bianchi, Matteo; Landegren, Nils; Nordin, Jessika et al.

Part of Journal of Internal Medicine, p. 595-608, 2016

• DOI for Extended exome sequencing identifies BACH2 as a novel major risk locus for Addison's disease
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Identification of Novel Sjogren's Syndrome Risk Loci in the Regions of TNFAIP3 and PRDM1

Lessard, Christopher J.; Li, He; Ice, John; Adrianto, Indra et al.

Part of Arthritis & Rheumatology, 2015

• DOI for Identification of Novel Sjogren's Syndrome Risk Loci in the Regions of TNFAIP3 and PRDM1

A Novel HLA-DRB1*10:01 Restricted T Cell Epitope from Citrullinated Type II Collagen Relevant for Rheumatoid Arthritis

Chemin, Karine; Pollastro, Sabrina; James, Eddie; Ge, Changrong et al.

Part of Arthritis & Rheumatology, 2015

• DOI for A Novel HLA-DRB1*10:01 Restricted T Cell Epitope from Citrullinated Type II Collagen Relevant for Rheumatoid Arthritis

Early B Cell Factor 1 is Associated to Clinical Manifestations in Primary Sjogren's Syndrome and SLE

Bolin, Karin; Leonard, Dag; Gunnarsson, I.; Sjowall, C. et al.

Part of Scandinavian Journal of Immunology, p. 416-416, 2015

Genome-Wide Analysis of DNA Methylation Profiles in Multiple Tissues in Primary Sjogren's Syndrome

Imgenberg-Kreuz, Juliana; Sandling, Johanna K.; Carlsson Almlöf, Jonas; Omdal, Roald et al.

Part of Scandinavian Journal of Immunology, p. 412-412, 2015

Immune complex mediated activation of plasmacytoid dendritic cells in SLE

Rönnblom, Lars

Part of Clinical and Experimental Rheumatology, 2015

Epigenome data release: a participant-centered approach to privacy protection

Dyke, Stephanie O M; Cheung, Warren A; Joly, Yann; Ammerpohl, Ole et al.

Part of Genome Biology, 2015

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Functional Anti-CD94/NKG2A and Anti-CD94/NKG2C Autoantibodies in Patients With Systemic Lupus Erythematosus

Hagberg, Niklas; Theorell, Jakob; Hjorton, Karin; Spee, Pieter et al.

Part of ARTHRITIS & RHEUMATOLOGY, p. 1000-1011, 2015

• DOI for Functional Anti-CD94/NKG2A and Anti-CD94/NKG2C Autoantibodies in Patients With Systemic Lupus Erythematosus

Genome-wide analysis of DNA methylation in systemic lupus erythematosus

Sandling, Johanna K.; Imgenberg-Kreuz, Juliana; Carlsson Almlöf, Jonas; Nordmark, Gunnel et al.

Part of Clinical and Experimental Rheumatology, 2015

IFN-α production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases

Berggren, Olof; Alexsson, Andrei; Morris, David; Tandre, Karolina et al.

Part of Human Molecular Genetics, p. 3571-3581, 2015

• DOI for IFN-α production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases

Hypomethylation in Enhancer and Promoter Regions of Interferon Regulated Genes in Multiple Tissues Is Associated with Primary Sjogren's Syndrome

Imgenberg-Kreuz, Juliana; Sandling, Johanna K.; Almlöf, Jonas Carlsson; Nordlund, Jessica et al.

Part of Arthritis & Rheumatology, 2015

• DOI for Hypomethylation in Enhancer and Promoter Regions of Interferon Regulated Genes in Multiple Tissues Is Associated with Primary Sjogren's Syndrome

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Allum, Fiona; Shao, Xiaojian; Guénard, Frédéric; Simon, Marie-Michelle et al.

Part of Nature Communications, 2015

• DOI for Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants
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Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Bentham, James; Morris, David L; Cunninghame Graham, Deborah S; Pinder, Christopher L et al.

Part of Nature Genetics, p. 1457-1464, 2015

• DOI for Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

An epigenome-wide association study of total serum immunoglobulin E concentration

Liang, Liming; Willis-Owen, Saffron A. G.; Laprise, Catherine; Wong, Kenny C. C. et al.

Part of Nature, p. 670-U188, 2015

• DOI for An epigenome-wide association study of total serum immunoglobulin E concentration

Recurrent Pyoderma Gangrenosum and Cystic Acne Associated with Leucocyte Adhesion Deficiency due to Novel Mutations in ITGB2: Successful Treatment with Infliximab and Adalimumab

Vahlquist, Anders; Håkansson, Lena Douhan; Rönnblom, Lars; Karawajczyk, Malgorzata et al.

Part of Acta Dermato-Venereologica, p. 349-351, 2015

• DOI for Recurrent Pyoderma Gangrenosum and Cystic Acne Associated with Leucocyte Adhesion Deficiency due to Novel Mutations in ITGB2: Successful Treatment with Infliximab and Adalimumab

High-Throughput Sequencing of 219 Candidate Genes for Identification of SLE-Associated Risk Variants

Farias, Fabiana; Wilbe, Maria; Dahlqvist, Johanna; Leonard, Dag et al.

Part of Arthritis & Rheumatology, 2014

Utility of Swedish Register Data in Classifying Systemic Lupus

Arkema, E.; Jonsen, A.; Rönnblom, Lars; Sjowall, C. et al.

Part of Annals of the Rheumatic Diseases, p. 444-444, 2014

• DOI for Utility of Swedish Register Data in Classifying Systemic Lupus

Activated T cells enhance interferon-alpha production by plasmacytoid dendritic cells stimulated by RNA-containing immune complexes

Leonard, Dag; Eloranta, Maija-Leena; Hagberg, Niklas; Berggren, Olof et al.

Part of Scandinavian Journal of Rheumatology, p. 88-89, 2014

Systemic Lupus Prevalence in Sweden in 2010: What do national registers say?

Simard, Julia F; Sjöwall, Christopher; Rönnblom, Lars; Jönsen, Andreas et al.

Part of Arthritis Care and Research, p. 1710-1717, 2014

• DOI for Systemic Lupus Prevalence in Sweden in 2010: What do national registers say?

Effect of single-nucleotide polymorphisms on type I interferon production by plasmacytoid dendritic cells stimulated with SLE-associated immune complexes

Berggren, Olof; Alexsson, Andrei; Tandre, Karolina; Syvanen, A-C et al.

Part of Scandinavian Journal of Rheumatology, p. 92-92, 2014

Activated SLE-T Cells Enhance the Interferon-Alpha Production By Plasmacytoid Dendritic Cells Stimulated By RNA-IC

Leonard, Dag; Eloranta, Maija-Leena; Hagberg, Niklas; Berggren, Olof et al.

Part of Arthritis & Rheumatology, 2014

Serum C-reactive protein (CRP) associates with lupus disease activity in the absence of measurable interferon alpha and a CRP gene variant

Enocsson, Helena; Sjöwall, Christopher; Kastbom, Alf; Skogh, Thomas et al.

Part of Arthritis & rheumatology, p. 1568-1573, 2014

• DOI for Serum C-reactive protein (CRP) associates with lupus disease activity in the absence of measurable interferon alpha and a CRP gene variant

Genome-Wide DNA Methylation Analysis of CD19+B Cells in Primary Sjogren's Syndrome

Nordmark, Gunnel; Imgenberg-Kreuz, Juliana; Almlöf, Jonas Carlsson; Nordlund, Jessica et al.

Part of Arthritis & Rheumatology, 2014

Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs

Adoue, Veronique; Schiavi, Alicia; Light, Nicholas; Carlsson Almlöf, Jonas et al.

Part of Molecular Systems Biology, p. 754, 2014

• DOI for Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs
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Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

Kilarski, Laura L.; Achterberg, Sefanja; Devan, William J.; Traylor, Matthew et al.

Part of Neurology, p. 678-685, 2014

• DOI for Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

Dual role of CpG-stimulated B cells in the regulation of dendritic cells: comment on the article by Berggren et al Reply

Eloranta, Maija-Leena; Rönnblom, Lars

Part of Arthritis and Rheumatism, p. 2216, 2013

• DOI for Dual role of CpG-stimulated B cells in the regulation of dendritic cells: comment on the article by Berggren et al Reply

Clinical manifestations and anti-phospholipid antibodies in 712 patients with systemic lupus erythematosus: evaluation of two diagnostic assays

Vikerfors, Anna; Johansson, Anna-Britta; Gustafsson, Johanna T; Jönsen, Andreas et al.

Part of Rheumatology, p. 345-353, 2013

• DOI for Clinical manifestations and anti-phospholipid antibodies in 712 patients with systemic lupus erythematosus: evaluation of two diagnostic assays

RNA-Seq for Enrichment and Analysis of IRF5 Transcript Expression in SLE

Stone, R. C.; Du, P.; Feng, D.; Dhawan, K. et al.

Part of PLOS ONE, p. 54487, 2013

• DOI for RNA-Seq for Enrichment and Analysis of IRF5 Transcript Expression in SLE
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Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus

Hagberg, Niklas; Theorell, Jakob; Eloranta, Maija-Leena; Pascal, Veronique et al.

Part of Rheumatology, p. 1818-1823, 2013

• DOI for Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus

NCR3/NKp30 Contributes to Pathogenesis in Primary Sjögren's Syndrome

Rusakiewicz, Sylvie; Nocturne, Gaetane; Lazure, Thierry; Semeraro, Michaela et al.

Part of Science Translational Medicine, 2013

• DOI for NCR3/NKp30 Contributes to Pathogenesis in Primary Sjögren's Syndrome

Brief Report: Interferon-α Induction and Detection of Anti-Ro, Anti-La, Anti-Sm, and Anti-RNP Autoantibodies by Autoantigen Microarray Analysis in Juvenile Dermatomyositis

Balboni, Imelda; Niewold, Timothy B; Morgan, Gabrielle; Limb, Cindy et al.

Part of Arthritis and Rheumatism, p. 2424-2429, 2013

• DOI for Brief Report: Interferon-α Induction and Detection of Anti-Ro, Anti-La, Anti-Sm, and Anti-RNP Autoantibodies by Autoantigen Microarray Analysis in Juvenile Dermatomyositis

No association of primary Sjogren's syndrome with Fc gamma receptor gene variants

Haldorsen, K; Appel, S; Le Hellard, S; Bruland, O et al.

Part of Genes and Immunity, p. 234-237, 2013

• DOI for No association of primary Sjogren's syndrome with Fc gamma receptor gene variants
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Two rare disease-associated tyk2 variants are catalytically impaired but signaling competent

Li, Zhi; Gakovic, Milica; Ragimbeau, Josiane; Eloranta, Maija-Leena et al.

Part of Journal of Immunology, p. 2335-2344, 2013

• DOI for Two rare disease-associated tyk2 variants are catalytically impaired but signaling competent

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

Lessard, Christopher J; Li, He; Adrianto, Indra; Ice, John A et al.

Part of Nature Genetics, p. 1284-1292, 2013

• DOI for Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

Disease Mechanisms in RheumatologyTools and Pathways: Plasmacytoid Dendritic Cells and Their Role in AutoimmuneRheumatic Diseases

Eloranta, Maija-Leena; Alm, Gunnar V; Rönnblom, Lars

Part of Arthritis and Rheumatism, p. 853-863, 2013

• DOI for Disease Mechanisms in RheumatologyTools and Pathways: Plasmacytoid Dendritic Cells and Their Role in AutoimmuneRheumatic Diseases

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Nordlund, Jessica; Bäcklin, Christofer L; Wahlberg, Per; Busche, Stephan et al.

Part of Genome Biology, 2013

• DOI for Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

Wang, Chuan; Ahlford, Annika; Järvinen, Tiina M; Nordmark, Gunnel et al.

Part of European Journal of Human Genetics, p. 994-999, 2013

• DOI for Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility

Wang, Chuan; Ahlford, Annika; Laxman, Navya; Nordmark, Gunnel et al.

Part of Genes and Immunity, p. 217-222, 2013

• DOI for Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility
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Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis

Bolin, Karin; Sandling, Johanna K; Zickert, Agneta; Jönsen, Andreas et al.

Part of PLOS ONE, 2013

• DOI for Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis
• Download full text (pdf) of Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis

Epitopes of Microbial and Human Heat Shock Protein 60 and Their Recognition in Myalgic Encephalomyelitis

Elfaitouri, Amal; Herrmann, Björn; Bölin-Wiener, Agnes; Wang, Yilin et al.

Part of PLOS ONE, p. 55, 2013

• DOI for Epitopes of Microbial and Human Heat Shock Protein 60 and Their Recognition in Myalgic Encephalomyelitis
• Download full text (pdf) of Epitopes of Microbial and Human Heat Shock Protein 60 and Their Recognition in Myalgic Encephalomyelitis

Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4

Wang, Chuan; Sandling, Johanna K; Hagberg, Niklas; Berggren, Olof et al.

Part of Annals of the Rheumatic Diseases, p. 96-103, 2013

• DOI for Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4

HLA-DRB1*04/*13 alleles are associated with vascular disease and antiphospholipid antibodies in systemic lupus erythematosus

Lundström, Emeli; Gustafsson, Johanna T; Jönsen, Andreas; Leonard, Dag et al.

Part of Annals of the Rheumatic Diseases, p. 1018-1025, 2013

• DOI for HLA-DRB1*04/*13 alleles are associated with vascular disease and antiphospholipid antibodies in systemic lupus erythematosus

The NKp30/B7H6 Axis Contributes To Pathogenesis In Primary Sjogren's Syndrome.

Nocturne, Gaetane; Rusakiewicz, Sylvie; Sene, Damien; Nordmark, Gunnel et al.

Part of Arthritis and Rheumatism, 2013

Direct and Indirect Costs For Patients With Systemic Lupus Erythematosus In National Cohorts In Sweden

Jonsen, Andreas; Bengtsson, Anders A.; Bengtsson, Christine; Gunnarsson, Iva et al.

Part of Arthritis and Rheumatism, 2013

Complex Functional Effects Within The HLA Contribute To Sjogren's Syndrome Pathogenesis and May Influence Both Transcriptional Regulation and Peptide Binding

Lessard, Christopher J.; Li, He; Adrianto, Indra; Ice, John A. et al.

Part of Arthritis and Rheumatism, 2013

Coronary heart disease in systemic lupus erythematosus is associated with interferon regulatory factor-8 gene variants

Leonard, Dag; Svenungsson, Elisabet; Sandling, Johanna K; Berggren, Olof et al.

Part of Circulation, p. 255-263, 2013

• DOI for Coronary heart disease in systemic lupus erythematosus is associated with interferon regulatory factor-8 gene variants

On the Origin of the Type I Interferon Activity in Rheumatoid Arthritis

de Jong, T. D.; Vosslamber, S.; Eloranta, Maija-Leena; Rönnblom, Lars et al.

Part of Annals of the Rheumatic Diseases, 2013

• DOI for On the Origin of the Type I Interferon Activity in Rheumatoid Arthritis

Systemic Lupus Erythematosus Immune Complexes Increase the Expression of SLAM Family Members CD319 (CRACC) and CD229 (LY-9) on Plasmacytoid Dendritic Cells and CD319 on CD56(dim) NK Cells

Hagberg, Niklas; Theorell, Jakob; Schlums, Heinrich; Eloranta, Maija-Leena et al.

Part of Journal of Immunology, p. 2989-2998, 2013

• DOI for Systemic Lupus Erythematosus Immune Complexes Increase the Expression of SLAM Family Members CD319 (CRACC) and CD229 (LY-9) on Plasmacytoid Dendritic Cells and CD319 on CD56(dim) NK Cells

Coronary Heart Disease in Systemic Lupus Erythematosus is Associated with Interferon Regulatory Factor 8 Gene Variants

Leonard, Dag; Svenungsson, E.; Sandling, J. K.; Berggren, Olof et al.

Part of Annals of the Rheumatic Diseases, p. 270-270, 2013

• DOI for Coronary Heart Disease in Systemic Lupus Erythematosus is Associated with Interferon Regulatory Factor 8 Gene Variants

Identification of Multiple Sjogren'S Syndrome Susceptibility Loci

Lessard, C. J.; Li, H.; Ice, J. A.; Adrianto, I. et al.

Part of Annals of the Rheumatic Diseases, p. 54-55, 2013

• DOI for Identification of Multiple Sjogren'S Syndrome Susceptibility Loci

Type I Interferonopathies

Rönnblom, Lars

Part of Annals of the Rheumatic Diseases, p. 8-8, 2013

• DOI for Type I Interferonopathies

IgG glycan hydrolysis by EndoS diminishes the pro-inflammatory properties of immune complexes from patients with SLE – a possible new treatment?

Lood, Christian; Allhorn, Maria; Lood, Rolf; Gullstrand, Birgitta et al.

Part of Annals of the Rheumatic Diseases, 2012

• DOI for IgG glycan hydrolysis by EndoS diminishes the pro-inflammatory properties of immune complexes from patients with SLE – a possible new treatment?

SLE immune complexes upregulate the expression of slamf7 (cd319) on plasmacytoid dendritic cells

Hagberg, Niklas; Theorell, Jakob; Alm, Gunnar V.; Eloranta, Maija-Leena et al.

Part of Annals of the Rheumatic Diseases, 2012

• DOI for SLE immune complexes upregulate the expression of slamf7 (cd319) on plasmacytoid dendritic cells

Association of STAT4, IRF5 and BLK polymorphisms with severity and outcome in lupus nephritis

Eriksson, Karin G.; Zickert, Agneta; Sandling, Johanna K.; Jonsen, Andreas et al.

Part of Annals of the Rheumatic Diseases, 2012

• DOI for Association of STAT4, IRF5 and BLK polymorphisms with severity and outcome in lupus nephritis

Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples

Bolstad, Anne Isine; Le Hellard, Stephanie; Kristjansdottir, Gudlaug; Vasaitis, Lilian et al.

Part of Annals of the Rheumatic Diseases, p. 981-988, 2012

• DOI for Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples

Pharmacokinetics, tolerability, and preliminary efficacy of ABR-215757, a new quinoline-3-carboxamide derivative, in murine and human SLE

Bengtsson, Anders A; Sturfelt, Gunnar; Lood, Christian; Rönnblom, Lars et al.

Part of Arthritis and Rheumatism, p. 1579-1588, 2012

• DOI for Pharmacokinetics, tolerability, and preliminary efficacy of ABR-215757, a new quinoline-3-carboxamide derivative, in murine and human SLE

Autoantibodies associated with RNA are more enriched than anti-dsDNA antibodies in circulating immune complexes in SLE

Åhlin, Erik; Mathsson, Linda; Eloranta, Maija-Leena; Jonsdottir, Thorunn et al.

Part of Lupus, p. 586-595, 2012

• DOI for Autoantibodies associated with RNA are more enriched than anti-dsDNA antibodies in circulating immune complexes in SLE

Polymorphisms in the Interferon Regulatory Factor 5 Gene are Associated with Anti-cyclic Citrullinated Peptide Antibody Negative Rheumatoid Arthritis

Sigurdsson, Snaevar; Padyukov, Leonid; Liljedahl, Ulrika; Alfredsson, Lars et al.

2012

 Reumatologisk forskning med försöksdjur är viktig för våra patienter: [Rheumatologic research with animal experiments is important for our patients]

Rudin, Anna; Sturfelt, Gunnar; Carlsten, Hans; Hafström, Ingiäld et al.

Part of Läkartidningen, p. 40-40, 2012

Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons

Stone, Rivka C; Feng, Di; Deng, Jing; Singh, Sukhwinder et al.

Part of Arthritis and Rheumatism, p. 788-798, 2012

• DOI for Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons

IgG glycan hydrolysis by EndoS diminishes the pro-inflammatory properties of immune complexes from patients with SLE: a possible new treatment?

Lood, Christian; Allhorn, Maria; Lood, Rolf; Gullstrand, Birgitta et al.

Part of Arthritis and Rheumatism, p. 2698-2706, 2012

• DOI for IgG glycan hydrolysis by EndoS diminishes the pro-inflammatory properties of immune complexes from patients with SLE: a possible new treatment?

B lymphocytes enhance the interferon-α production by plasmacytoid dendritic cells

Berggren, Olof; Hagberg, Niklas; Weber, Gert; Alm, Gunnar V et al.

Part of Arthritis and Rheumatism, p. 3409-3419, 2012

• DOI for B lymphocytes enhance the interferon-α production by plasmacytoid dendritic cells

On the Origin of the Type I Interferon Signature in Rheumatoid Arthritis

de Jong, T. D.; Vosslamber, Saskia; Eloranta, Maija-Leena; Rönnblom, Lars et al.

Part of Arthritis and Rheumatism, 2012

Systemic Lupus Erythematosus Immune Complexes Upregulate the Expression of CD319 and CD229 On Plasmacytoid Dendritic Cells

Hagberg, Niklas; Theorell, Jakob; Alm, Gunnar V.; Eloranta, Maija-Leena et al.

Part of Arthritis and Rheumatism, 2012

Genetic Variation in the NCR3 Locus Is Associated with Anti-SSA/SSB Positive Primary Sjogren's Syndrome in Scandinavian Samples

Nordmark, Gunnel; Eloranta, Maija-Leena; Eriksson, Per; Theander, Elke et al.

Part of Arthritis and Rheumatism, 2012

Variation of Interferon-Alpha Production in Healthy Individuals and Association with Autoimmune Susceptibility Genes

Berggren, Olof; Alexsson, Andrei; Alm, Gunnar V.; Syvanen, Ann-Christine et al.

Part of Arthritis and Rheumatism, 2012

IFN-α Production by Plasmacytoid Dendritic Cells Stimulated with RNA-Containing Immune Complexes Is Promoted by NK Cells via MIP-1β and LFA-1

Hagberg, Niklas; Berggren, Olof; Leonard, Dag; Weber, Gert et al.

Part of Journal of Immunology, p. 5085-5094, 2011

• DOI for IFN-α Production by Plasmacytoid Dendritic Cells Stimulated with RNA-Containing Immune Complexes Is Promoted by NK Cells via MIP-1β and LFA-1

Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus

Jonsen, Andreas; Nilsson, Sara C; Ahlqvist, Emma; Svenungsson, Elisabet et al.

Part of Arthritis Research & Therapy, 2011

• DOI for Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
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Increased carotid intima thickness and decreased media thickness in premenopausal women with systemic lupus erythematosus: an investigation by non-invasive high-frequency ultrasound

Leonard, Dag; Akhter, Tansim; Nordmark, Gunnel; Rönnblom, Lars et al.

Part of Scandinavian Journal of Rheumatology, p. 279-282, 2011

• DOI for Increased carotid intima thickness and decreased media thickness in premenopausal women with systemic lupus erythematosus: an investigation by non-invasive high-frequency ultrasound

Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome

Nordmark, Gunnel; Kristjansdottir, Gudlaug; Theander, E.; Appel, S. et al.

Part of Genes and Immunity, p. 100-109, 2011

• DOI for Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome

Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome

Appel, Silke; Le Hellard, Stephanie; Bruland, Ove; Brun, Johan G. et al.

Part of Annals of the Rheumatic Diseases, p. 1327-1329, 2011

• DOI for Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome

TSGA10-A Target for Autoantibodies in Autoimmune Polyendocrine Syndrome Type 1 and Systemic Lupus Erythematosus

Smith, C. J. A.; Oscarson, M.; Rönnblom, Lars; Alimohammadi, Mohammad et al.

Part of Scandinavian Journal of Immunology, p. 147-153, 2011

• DOI for TSGA10-A Target for Autoantibodies in Autoimmune Polyendocrine Syndrome Type 1 and Systemic Lupus Erythematosus

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

Sandling, Johanna K.; Garnier, Sophie; Sigurdsson, Snaevar; Wang, Chuan et al.

Part of European Journal of Human Genetics, p. 479-484, 2011

• DOI for A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

Cunninghame Graham, Deborah S; Morris, David L; Bhangale, Tushar R; Criswell, Lindsey A et al.

Part of PLoS genetics, 2011

• DOI for Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

Type I interferon system activation and association with disease manifestations in systemic sclerosis

Eloranta, Maija-Leena; Franck-Larsson, Karin; Lövgren, Tanja; Kalamajski, Sebastian et al.

Part of Annals of the Rheumatic Diseases, p. 1396-1402, 2010

• DOI for Type I interferon system activation and association with disease manifestations in systemic sclerosis

Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus

Feng, Di; Stone, Rivka C.; Eloranta, Maija-Leena; Sangster-Guity, Niquiche et al.

Part of Arthritis and Rheumatism, p. 562-573, 2010

• DOI for Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus

Cytokines as therapeutic targets in SLE

Rönnblom, Lars; Elkon, Keith B.

Part of Nature Reviews Rheumatology, p. 339-347, 2010

• DOI for Cytokines as therapeutic targets in SLE

A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus

Svenungsson, Elisabet; Gustafsson, Johanna; Leonard, Dag; Sandling, Johanna et al.

Part of Annals of the Rheumatic Diseases, p. 834-840, 2010

• DOI for A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus

Interferon-alpha Mediates Suppression of C-Reactive Protein Explanation for Muted C-Reactive Protein Response in Lupus Flares?

Enocsson, Helena; Sjöwall, Christopher; Skogh, Thomas; Eloranta, Maija-Leena et al.

Part of Arthritis and Rheumatism, p. 3755-3760, 2009

• DOI for Interferon-alpha Mediates Suppression of C-Reactive Protein Explanation for Muted C-Reactive Protein Response in Lupus Flares?

C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis

Lood, Christian; Gullstrand, Birgitta; Truedsson, Lennart; Olin, Anders I. et al.

Part of Arthritis and Rheumatism, p. 3081-3090, 2009

• DOI for C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis

Systemic lupus erythematosus: a matter of life and death

Pisetsky, David S.; Rönnblom, Lars

Part of Arthritis and Rheumatism, p. 1567-1570, 2009

• DOI for Systemic lupus erythematosus: a matter of life and death

Use of a commercial line blot assay as a screening test for autoantibodies in inflammatory myopathies

Rönnelid, Johan; Barbasso Helmers, Sevim; Storfors, Helena; Grip, Katarina et al.

Part of Autoimmunity Reviews, p. 58-61, 2009

• DOI for Use of a commercial line blot assay as a screening test for autoantibodies in inflammatory myopathies

Systemic Lupus Erythematosus: a matter of life and death

Pisetsky, David S.; Rönnblom, Lars

Part of Arthritis and Rheumatism, p. 1567-1570, 2009

• DOI for Systemic Lupus Erythematosus: a matter of life and death

Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE

Isaksson, Magnus; Ardesjö, Brita; Rönnblom, Lars; Kämpe, Olle et al.

Part of European Journal of Immunology, p. 2925-2935, 2009

• DOI for Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE

Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells

Eloranta, Maija-Leena; Lövgren, Tanja; Finke, Doreen; Mathsson, Linda et al.

Part of Arthritis and Rheumatism, p. 2418-2427, 2009

• DOI for Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells

Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome

Nordmark, Gunnel; Kristjansdottir, Gudlaug; Theander, E.; Eriksson, P. et al.

Part of Genes and Immunity, p. 68-76, 2009

• DOI for Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Gateva, Vesela; Sandling, Johanna K.; Hom, Geoff; Taylor, Kimberly E. et al.

Part of Nature Genetics, p. 1228-1233, 2009

• DOI for A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

Sigurdsson, Snaevar; Nordmark, Gunnel; Garnier, Sophie; Grundberg, Elin et al.

Part of Human Molecular Genetics, p. 2868-2876, 2008

• DOI for A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

The innate immune system in SLE: type I interferons and dendritic cells

Rönnblom, Lars; Pascual, V.

Part of Lupus, p. 394-399, 2008

• DOI for The innate immune system in SLE: type I interferons and dendritic cells

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

Hom, Geoffrey; Graham, Robert R; Modrek, Barmak; Taylor, Kimberly E et al.

Part of New England Journal of Medicine, p. 900-909, 2008

• DOI for Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus

Sigurdsson, Snaevar; Göring, Harald H. H.; Kristjansdottir, Gudlaug; Milani, Lili et al.

Part of Human Molecular Genetics, p. 872-881, 2008

• DOI for Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus

Serum levels of sex steroid hormones and matrix metalloproteinases after intra-articular glucocorticoid treatment in female patients with rheumatoid arthritis

Weitoft, Tomas; Larsson, Anders; Rönnblom, Lars

Part of Annals of the Rheumatic Diseases, p. 422-424, 2008

• DOI for Serum levels of sex steroid hormones and matrix metalloproteinases after intra-articular glucocorticoid treatment in female patients with rheumatoid arthritis

A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus

Linga-Reddy, M. V. Prasad; Gunnarsson, I; Svenungsson, E; Sturfelt, G et al.

Part of Tissue Antigens, p. 412-414, 2007

• DOI for A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus

Graham, R. Robert; Kyogoku, Chieko; Sigurdsson, Snaevar; Vlasova, Irina A. et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 6758-6763, 2007

• DOI for Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus

Association of a Haplotype in the Promoter Region of the Interferon Regulatory Factor 5 Gene With Rheumatoid Arthritis

Sigurdsson, Snaevar; Padyukov, Leonid; Kurreeman, Fina A.S.; Liljedahl, Ulrika et al.

Part of Arthritis and Rheumatism, p. 2202-2210, 2007

• DOI for Association of a Haplotype in the Promoter Region of the Interferon Regulatory Factor 5 Gene With Rheumatoid Arthritis

A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies

Eloranta, Maija-Leena; Helmers, Sevim Barbasso; Ulfgren, Ann-Kristin; Rönnblom, Lars et al.

Part of Arthritis and Rheumatism, p. 3112-3124, 2007

• DOI for A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies

Induction of interferon-α by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA

Lövgren, Tanja; Eloranta, Maija-Leena; Kastner, Berthold; Wahren-Herlenius, Marie et al.

Part of Arthritis and Rheumatism, p. 1917-1927, 2006

• DOI for Induction of interferon-α by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA

Glucocorticoid resorption and influence on the hypothalamic-pituitary-adrenal axis after intra-articular treatment of the knee in resting and mobile patients.

Weitoft, T; Rönnblom, L

Part of Ann Rheum Dis, p. 955-7, 2006

Betungande regler för klinisk forskning står inte i proportion till patientnyttan

Vahlquist, Anders; Westermark, Per; Ståhle, Elisabeth; Venge, Per et al.

Part of Läkartidningen, p. 1832-1834, 2005

Betungande regler för klinisk prövning står inte i proportion till patientnyttan

Vahlquist, Anders; Westermark, Per; Ståhle, Elisabeth; Venge, Per et al.

Part of Läkartidningen, p. 1832-1834, 2005

Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism

Båve, Ullvi; Nordmark, Gunnel; Lövgren, Tanja; Rönnelid, Johan et al.

Part of Arthritis and Rheumatism, p. 1185-1195, 2005

• DOI for Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism

Changes of cartilage and bone markers after intra- articular glucocorticoid treatment with and without postinjection rest in patients with rheumatoid arthritis

Weitoft, Tomas; Larsson, Anders; Saxne, Tore; Rönnblom, Lars

Part of Annals of the Rheumatic Diseases, p. 1750-1753, 2005

• DOI for Changes of cartilage and bone markers after intra- articular glucocorticoid treatment with and without postinjection rest in patients with rheumatoid arthritis

Effects of Dehydroepiandrosterone Supplement on Health-related Quality of Life in Glucocorticoid Treated Female Patients with Systemic Lupus Erythematosus

Nordmark, Gunnel; Bengtsson, Christine; Larsson, Anders; Karlsson, Anders et al.

Part of Autoimmunity, p. 531-540, 2005

• DOI for Effects of Dehydroepiandrosterone Supplement on Health-related Quality of Life in Glucocorticoid Treated Female Patients with Systemic Lupus Erythematosus

Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation.

Nilsson Ekdahl, Kristina; Bengtsson, Anders A; Andersson, Jonas; Elgue, Graciela et al.

Part of Br J Haematol, p. 74, 2004

Induction of interferon-α production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG

Lövgren, Tanja; Eloranta, Maija-Leena; Båve, Ullvi; Alm, Gunnar V. et al.

Part of Arthritis and Rheumatism, p. 1861-1872, 2004

• DOI for Induction of interferon-α production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG

The heterogeneity of neuropsychiatric systemic lupus erythematosus isreflected in lack of association with cerebrospinal fluid cytokineprofiles

Jonsen, A; Bengtsson, AA; Nived, O; Ryberg, B et al.

Part of Lupus, p. 846-850, 2003

Single-tube nested quantitative PCR: a rational and sensitive technique for detection of retroviral DNA. Application to RERV-H/HRV-5 and confirmation of its rabbit origin

Forsman, Anna; Uzameckis, Dmitrijs; Rönnblom, Lars; Baecklund, Eva et al.

Part of Journal of Virological Methods, p. 1-11, 2003

• DOI for Single-tube nested quantitative PCR: a rational and sensitive technique for detection of retroviral DNA. Application to RERV-H/HRV-5 and confirmation of its rabbit origin

Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG

Båve, Ullvi; Magnuson, Mattias; Eloranta, Maija-Leena; Perers, Anders et al.

Part of Journal of Immunology, p. 3296-302, 2003

Autoantibodies to alpha-fodrin in primary Sjogren's syndrome and SLEdetected by an in vitro transcription and translation assay.

Nordmark, G; Rorsman, F; Ronnblom, L; Cajander, S et al.

Part of Clin Exp Rheumatol, p. 49, 2003

Randomised controlled study of postinjection immobilisation after intra-articular glucocorticoid treatment for wrist synovitis.

Weitoft, T; Rönnblom, L

Part of Ann Rheum Dis, p. 1013-5, 2003

Identification of AHNAK as a novel autoantigen in systemic lupuserythematosus

Sköldberg, Filip; Rönnblom, Lars; Thornemo, M; Lindahl, A et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 951-958, 2002

• DOI for Identification of AHNAK as a novel autoantigen in systemic lupuserythematosus

An etiopathogenic role for the type I IFN system in SLE.

Ronnblom, L; Alm, GV

Part of Trends Immunol, p. 427, 2001

The combination of apoptotic U937 cells and lupus IgG is a potent IF inducer

Båve, Ullvi; Alm, Gunar V.; Rönnblom, Lars

Part of Journal of Immunology, p. 3519-26, 2000

Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider

Rodriguez-Carrio, Javier; Burska, Agata; Conaghan, P. G.; Dik, Willem A. et al.

Part of RMD Open, 2023

• DOI for Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
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Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider

Burska, Agata; Rodriguez-Carrio, Javier; Biesen, Robert; Dik, Willem A. et al.

Part of RMD Open, 2023

• DOI for Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
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Technological readiness and implementation of genomic-driven precision medicine for complex diseases

Franks, P. W.; Melén, E.; Friedman, M.; Sundström, Johan et al.

Part of Journal of Internal Medicine, p. 602-620, 2021

• DOI for Technological readiness and implementation of genomic-driven precision medicine for complex diseases
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Interferon pathway in SLE: one key to unlocking the mystery of the disease

Rönnblom, Lars; Leonard, Dag

Part of Lupus Science and Medicine, 2019

• DOI for Interferon pathway in SLE: one key to unlocking the mystery of the disease
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Type I interferons in host defence and inflammatory diseases

Crow, Mary K.; Rönnblom, Lars

Part of Lupus Science and Medicine, 2019

• DOI for Type I interferons in host defence and inflammatory diseases
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An update on the role of type I interferons in systemic lupus erythematosus and Sjogren's syndrome

Thorlacius, Gudny Ella; Wahren-Herlenius, Marie; Rönnblom, Lars

Part of Current Opinion in Rheumatology, p. 471-481, 2018

• DOI for An update on the role of type I interferons in systemic lupus erythematosus and Sjogren's syndrome

Report of the inaugural Interferon Research Summit: interferon in inflammatory diseases

Crow, Mary K.; Rönnblom, Lars

Part of Lupus Science and Medicine, 2018

• DOI for Report of the inaugural Interferon Research Summit: interferon in inflammatory diseases
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Systemic lupus erythematosus: still a challenge for physicians

Bengtsson, A. A.; Rönnblom, Lars

Part of Journal of Internal Medicine, p. 52-64, 2017

• DOI for Systemic lupus erythematosus: still a challenge for physicians

Direct and indirect costs for systemic lupus erythematosus in Sweden. A nationwide health economic study based on five defined cohorts

Jönsen, Andreas; Hjalte, Frida; Willim, Minna; Carlsson, Katarina Steen et al.

Part of Seminars in Arthritis & Rheumatism, p. 684-690, 2016

• DOI for Direct and indirect costs for systemic lupus erythematosus in Sweden. A nationwide health economic study based on five defined cohorts

Systemic lupus erythematosus: a disease with a dysregulated type I interferon system

Hagberg, Niklas; Rönnblom, Lars

Part of Scandinavian Journal of Immunology, p. 199-207, 2015

• DOI for Systemic lupus erythematosus: a disease with a dysregulated type I interferon system

The interferon signature in autoimmune diseases

Rönnblom, Lars; Eloranta, Maija-Leena

Part of Current Opinion in Rheumatology, p. 248-253, 2013

• DOI for The interferon signature in autoimmune diseases

Type I Interferons in Sjögren's Syndrome

Yao, Yihong; Liu, Zheng; Jallal, Bahija; Shen, Nan et al.

Part of Autoimmunity Reviews, p. 558-566, 2013

• DOI for Type I Interferons in Sjögren's Syndrome

Primary Sjögren's syndrome and the type I interferon system

Nordmark, Gunnel; Eloranta, Maija-Leena; Rönnblom, Lars

Part of Current Pharmaceutical Biotechnology, p. 2054-2062, 2012

The type I interferon system in the etiopathogenesis of autoimmune diseases

Rönnblom, Lars

Part of Upsala Journal of Medical Sciences, p. 227-237, 2011

• DOI for The type I interferon system in the etiopathogenesis of autoimmune diseases

The type I interferon system in the development of lupus

Rönnblom, Lars; Alm, Gunnar V; Eloranta, Maija-Leena

Part of Seminars in Immunology, p. 113-121, 2011

• DOI for The type I interferon system in the development of lupus

Potential role of IFNα in adult lupus

Rönnblom, Lars

Part of Arthritis Research & Therapy, 2010

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Endogenous type I interferon inducers in autoimmune diseases

Finke, Doreen; Eloranta, Maija-Leena; Rönnblom, Lars

Part of Autoimmunity, p. 349-352, 2009

• DOI for Endogenous type I interferon inducers in autoimmune diseases

Type I interferon and lupus

Rönnblom, Lars; Alm, Gunnar V.; Eloranta, Maija-Leena

Part of Current Opinion in Rheumatology, p. 471-477, 2009

• DOI for Type I interferon and lupus

The Interferon System in Lupus Erythematosus

Hagberg, Niklas; Rönnblom, Lars

Part of Systemic Lupus Erythematosus, p. 153-158, Academic Press, 2016

• DOI for The Interferon System in Lupus Erythematosus

The interferons. Further targeted therapies in rheumatology

Rönnblom, Lars; Eloranta, Maija-Leena; Alm, Gunnar

Part of Informa Healthcare, 2007

Activated T cells enhance interferon-alpha production by plasmacytoid dendritic cells stimulated by RNA-containing immune complexes

Leonard, Dag; Eloranta, Maija-Leena; Hagberg, Niklas; Berggren, Olof et al.

Dissection of genes in the type I interferon pathway reveals two novel risk loci for SLE

Sandling, Johanna K; Garnier, Sophie; Sigurdsson, Snaevar; Wang, Chuan et al.

From genetic predisposition to clinical outcome in systemic lupus erythematosus: construction and validation of sub-phenotype-specific genetic risk scores

Reid, Sarah; Sandling, Johanna K.; Pucholt, Pascal; Sayadi, Ahmed et al.

Variants in BANK1 are associated with lupus nephritis

Bolin, Karin; Leonard, Dag; Sandling, Johanna K.; Imgenberg-Kreuz, Juliana et al.