Ulrika Yngve
Researcher at Department of Medicinal Chemistry; Preparative Medicinal Chemistry
- Telephone:
- +46 18 471 41 24
- E-mail:
- ulrika.yngve@scilifelab.uu.se
- Visiting address:
- Uppsala Biomedicinska Centrum, BMC, Husarg. 3
- Postal address:
- Box 574
751 23 UPPSALA
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Short presentation
Head of Facility, Medicinal Chemistry, Lead Identification, Drug Discovery and Development Platform, Science for Life Laboratory. Information about the platform can be found at https://www.scilifelab.se/platforms/ddd.
Publications
Selection of publications
- Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability (2020)
- A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (2018)
- Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting (2017)
- Triazolopyrimidinones as gamma-secretase modulators (2013)
- Imidazopyridine-based inhibitors of glycogen synthase kinase 3 (2012)
Recent publications
- Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability (2020)
- A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (2018)
- Automated GMP-production of α-[11 C]methyl-L-tryptophan using a tracer production system (TPS) (2018)
- Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting (2017)
- Tracing BACE (2015)
All publications
Articles
- Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability (2020)
- A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (2018)
- Automated GMP-production of α-[11 C]methyl-L-tryptophan using a tracer production system (TPS) (2018)
- Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting (2017)
- Tracing BACE (2015)
- Triazolopyrimidinones as gamma-secretase modulators (2013)
- 3-Oxoisoindoline-1-carboxamides (2012)
- Imidazopyridine-based inhibitors of glycogen synthase kinase 3 (2012)
- Microwave accelerated 68Ga-labelling of oligonucleotides (2004)
- Hybridisation of [Br-76]-labelled antisense oligonucleotides to Chromogranin A mRNA verified by RT-PCR (2004)
- Labelling of octreotide using Br-76-prosthetic groups (2001)
- Determination of specific radioactivity for Br-76-labeled compounds measuring the ratio between Br-76 and Br-79 using packed capillary liquid chromatography mass spectrometry (2000)
- Distribution of Br-76-labeled antisense oligonucleotides of different length determined ex vivo in rats (2000)
- Compounds labelled with short-lived beta(+)-emitting radionuclides and some applications in life sciences. The importance of time as a parameter (1999)
- Synthesis of N-Succinimidyl 4-[76Br]Bromobenzoate and its Use in Conjugation Labelling of Macromolecules (1999)
Conferences
- Tritium labeling of a class of spirooxazaindolamines possessing analgesic properties. (2004)
- Synthesis of N-succinimidyl-4-[76Br]bromobenzoate and its use in labeling of amino-containing macromolecules. (1998)
Patents
- Preparation of pyrimidinylamine compounds as gamma secretase modulators useful for treatment of Aβ-related diseases. (2014)
- Preparation of aminotriazole compounds as gamma secretase modulators useful for treatment of Aβ-related diseases. (2014)
- Preparation of azetidinotriazole compounds as gamma secretase modulators useful for treatment of Aβ-related diseases. (2014)
- Preparation of 1-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)piperazine derivatives as glycogen synthase kinase 3 inhibitors. (2011)
- Preparation of arylimidazopyridine derivatives for use as GSK3 modulators. (2008)
- Preparation of imidazopyridinecarboxamide derivatives for use as GSK3 modulators. (2008)
- Preparation of imidazolyl-pyrimidine derivatives as GSK3 inhibitors. (2008)
- Preparation of piperazinyl quinazolines as 5-HT6 modulators. (2007)
- Preparation of piperazinyl quinazolines as 5-HT6 modulators. (2007)
- Benzoic acid derivatives as glycine receptor inhibitors, their preparation, pharmaceutical compositions, and use in therapy. (2006)
- Preparation of five-membered heterocyclic compounds as mGluR5 receptor antagonists. (2004)