Ulrika Yngve

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona et al.

Part of Journal of Medicinal Chemistry, p. 3915-3934, 2020

• DOI for Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
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A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, Marcus J. G. W.; van Leeuwen, Ingeborg M. M.; Drummond, Catherine J.; Chu, Su et al.

Part of Nature Communications, 2018

• DOI for A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
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Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Part of Neuropharmacology, p. 293-300, 2017

• DOI for Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Triazolopyrimidinones as gamma-secretase modulators: structure-activity relationship, modulator profile, and in vivo profiling

Yngve, Ulrika; Paulsen, Kim; Macsari, Istvan; Sundstrom, Marie et al.

Part of MedChemComm, p. 422-431, 2013

• DOI for Triazolopyrimidinones as gamma-secretase modulators: structure-activity relationship, modulator profile, and in vivo profiling

Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold

Yngve, Ulrika; Söderman, Peter; Svensson, Mats; Rosqvist, Susanne et al.

Part of Chemistry and Biodiversity, p. 2442-2452, 2012

• DOI for Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold

Toward generalizable predictive models for DNA-encoded libraries

Poongavanam, Vasanthanathan; Turunen, S Pauliina; Sandberg, Kristian; Yngve, Ulrika et al.

Part of Drug Discovery Today, 2026

• DOI for Toward generalizable predictive models for DNA-encoded libraries
• Download full text (pdf) of Toward generalizable predictive models for DNA-encoded libraries

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona et al.

Part of Journal of Medicinal Chemistry, p. 3915-3934, 2020

• DOI for Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
• Download full text (pdf) of Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, Marcus J. G. W.; van Leeuwen, Ingeborg M. M.; Drummond, Catherine J.; Chu, Su et al.

Part of Nature Communications, 2018

• DOI for A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
• Download full text (pdf) of A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Automated GMP-production of α-[¹¹ C]methyl-L-tryptophan using a tracer production system (TPS)

Nordeman, Patrik; Yngve, Ulrika; Wilking, Helena; Gustavsson, Sven Åke et al.

Part of Journal of labelled compounds & radiopharmaceuticals, p. 1106-1109, 2018

• DOI for Automated GMP-production of α-[¹¹ C]methyl-L-tryptophan using a tracer production system (TPS)

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Part of Neuropharmacology, p. 293-300, 2017

• DOI for Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Toward generalizable predictive models for DNA-encoded libraries

Poongavanam, Vasanthanathan; Turunen, S Pauliina; Sandberg, Kristian; Yngve, Ulrika et al.

Part of Drug Discovery Today, 2026

• DOI for Toward generalizable predictive models for DNA-encoded libraries
• Download full text (pdf) of Toward generalizable predictive models for DNA-encoded libraries

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona et al.

Part of Journal of Medicinal Chemistry, p. 3915-3934, 2020

• DOI for Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
• Download full text (pdf) of Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, Marcus J. G. W.; van Leeuwen, Ingeborg M. M.; Drummond, Catherine J.; Chu, Su et al.

Part of Nature Communications, 2018

• DOI for A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
• Download full text (pdf) of A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Automated GMP-production of α-[¹¹ C]methyl-L-tryptophan using a tracer production system (TPS)

Nordeman, Patrik; Yngve, Ulrika; Wilking, Helena; Gustavsson, Sven Åke et al.

Part of Journal of labelled compounds & radiopharmaceuticals, p. 1106-1109, 2018

• DOI for Automated GMP-production of α-[¹¹ C]methyl-L-tryptophan using a tracer production system (TPS)

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Part of Neuropharmacology, p. 293-300, 2017

• DOI for Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Tracing BACE: Synthesis and evaluation of beta-secretase inhibitors as ligands for PET imaging

Yngve, Ulrika; Nordeman, Patrik; Estrada, Sergio; Marklund, Niklas et al.

Part of Journal of labelled compounds & radiopharmaceuticals, 2015

Triazolopyrimidinones as gamma-secretase modulators: structure-activity relationship, modulator profile, and in vivo profiling

Yngve, Ulrika; Paulsen, Kim; Macsari, Istvan; Sundstrom, Marie et al.

Part of MedChemComm, p. 422-431, 2013

• DOI for Triazolopyrimidinones as gamma-secretase modulators: structure-activity relationship, modulator profile, and in vivo profiling

Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold

Yngve, Ulrika; Söderman, Peter; Svensson, Mats; Rosqvist, Susanne et al.

Part of Chemistry and Biodiversity, p. 2442-2452, 2012

• DOI for Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold

3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na(V)1.7 with Efficacy in Rat Pain Models

Macsari, Istvan; Besidski, Yeygeni; Csjernyik, Gabor; Nilsson, Linda I. et al.

Part of Journal of Medicinal Chemistry, p. 6866-6880, 2012

• DOI for 3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na(V)1.7 with Efficacy in Rat Pain Models

Hybridisation of [Br-76]-labelled antisense oligonucleotides to Chromogranin A mRNA verified by RT-PCR

Wu, F; Lendvai, G; Yngve, U; Eriksson, B et al.

Part of Nuclear Medicine and Biology, p. 1073-1078, 2004

• DOI for Hybridisation of [Br-76]-labelled antisense oligonucleotides to Chromogranin A mRNA verified by RT-PCR

Microwave accelerated 68Ga-labelling of oligonucleotides

Velikyan, Irina; Lendvai, Gabor; Välilä, Maria; Roivainen, Anne et al.

Part of Journal of Labelled Compounds & Radiopharmaceuticals, p. 79-89, 2004

Labelling of octreotide using Br-76-prosthetic groups

Yngve, Ulrika; Khan, Tanweera Shaheena; Bergström, Mats; Långstrom, Bengt

Part of Journal of labelled compounds & radiopharmaceuticals, p. 561-573, 2001

• DOI for Labelling of octreotide using Br-76-prosthetic groups

Distribution of Br-76-labeled antisense oligonucleotides of different length determined ex vivo in rats

Wu, F; Yngve, U; Hedberg, E; Honda, M et al.

Part of European Journal of Pharmaceutical Sciences, p. 179-186, 2000

• DOI for Distribution of Br-76-labeled antisense oligonucleotides of different length determined ex vivo in rats

Determination of specific radioactivity for Br-76-labeled compounds measuring the ratio between Br-76 and Br-79 using packed capillary liquid chromatography mass spectrometry

Forngren, B H; Yngve, U; Forngren, T; Langstrom, B

Part of Nuclear Medicine and Biology, p. 851-853, 2000

• DOI for Determination of specific radioactivity for Br-76-labeled compounds measuring the ratio between Br-76 and Br-79 using packed capillary liquid chromatography mass spectrometry

Synthesis of N-Succinimidyl 4-[76Br]Bromobenzoate and its Use in Conjugation Labelling of Macromolecules

Yngve, Ulrika; Hedberg, Elisabeth; Lövqvist, Anna; Tolmachev, Vladimir et al.

Part of Acta Chemica Scandinavica, p. 508-512, 1999

• DOI for Synthesis of N-Succinimidyl 4-[76Br]Bromobenzoate and its Use in Conjugation Labelling of Macromolecules

Compounds labelled with short-lived beta(+)-emitting radionuclides and some applications in life sciences. The importance of time as a parameter

Langstrom, B; Kihlberg, T; Bergstrom, M; Antoni, G et al.

Part of Acta Chemica Scandinavica, p. 651-669, 1999

• DOI for Compounds labelled with short-lived beta(+)-emitting radionuclides and some applications in life sciences. The importance of time as a parameter

Tritium labeling of a class of spirooxazaindolamines possessing analgesic properties.

Stroem, Peter; Malmquist, Jonas; Hansson, Jonas; Yngve, Ulrika et al.

Part of Synth. Appl. Isot. Labelled Compd., Proc. Int. Symp., 8th, p. 285-288, 2004

Synthesis of N-succinimidyl-4-[76Br]bromobenzoate and its use in labeling of amino-containing macromolecules.

Yngve, U.; Hedberg, E.; Tolmachev, V.; Langstrom, B.

Part of Synth. Appl. Isot. Labelled Compd. 1997, Proc. Int. Symp., 6th, p. 303-305, 1998

Preparation of azetidinotriazole compounds as gamma secretase modulators useful for treatment of Aβ-related diseases.

Besidski, Yevgeni; Yngve, Ulrika; Paulsen, Kim; Linde, Christian et al.

2014

Preparation of pyrimidinylamine compounds as gamma secretase modulators useful for treatment of Aβ-related diseases.

Besidski, Yevgeni; Yngve, Ulrika; Paulsen, Kim; Linde, Christian et al.

2014

Preparation of aminotriazole compounds as gamma secretase modulators useful for treatment of Aβ-related diseases.

Besidski, Yevgeni; Yngve, Ulrika; Paulsen, Kim; Linde, Christian et al.

2014

Preparation of 1-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)piperazine derivatives as glycogen synthase kinase 3 inhibitors.

Aahlin, Kristofer; Arvidsson, Per I.; Huerta, Fernando; Yngve, Ulrika.

2011

Preparation of imidazolyl-pyrimidine derivatives as GSK3 inhibitors.

Burrows, Jeremy; Huerta, Fernando; Lake, Fredrik; Pedersen, Torben et al.

2008

Preparation of arylimidazopyridine derivatives for use as GSK3 modulators.

Arvidsson, Per; Burrows, Jeremy; Soederman, Peter; Yngve, Ulrika.

2008

Preparation of imidazopyridinecarboxamide derivatives for use as GSK3 modulators.

Arvidsson, Per; Burrows, Jeremy; Soederman, Peter; Yngve, Ulrika.

2008

Preparation of piperazinyl quinazolines as 5-HT6 modulators.

Nordvall, Gunnar; Yngve, Ulrika.

2007

Preparation of piperazinyl quinazolines as 5-HT6 modulators.

Nordvall, Gunnar; Yngve, Ulrika.

2007

Benzoic acid derivatives as glycine receptor inhibitors, their preparation, pharmaceutical compositions, and use in therapy.

Gybaeck, Helena; Haeberlein, Markus; Jonasson, Catrin; Kihlstroem, Jacob et al.

2006

Preparation of five-membered heterocyclic compounds as mGluR5 receptor antagonists.

Wensbo, David; Xin, Tao; Stefanac, Tomislav; Arora, Jalaj et al.

2004