Angelica Loskog

Tumor Microenvironment Gene Engineering with LOAd703 in Patients with Solid Malignancies: LOKON002 Phase I/IIb Clinical Trial

Hahn, Amanda; Irenaeus, Sandra; Sandin, Linda C.; Nordström, Clara et al.

Part of Clinical Cancer Research, p. 3157-3168, 2026

• DOI for Tumor Microenvironment Gene Engineering with LOAd703 in Patients with Solid Malignancies: LOKON002 Phase I/IIb Clinical Trial

LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial

Hamid, O.; Ekström-Rydén, Viktoria; Mehmi, I.; Wang, D. et al.

Part of Nature Communications, 2026

• DOI for LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial
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Reprogramming myeloid cells and restoring T cell fitness in checkpoint inhibitor resistant melanoma patients

Grauers Wiktorin, Hanna; Rydén, Viktoria; Ek, Ida; Eriksson, Emma et al.

Part of Biomarker Research, 2026

• DOI for Reprogramming myeloid cells and restoring T cell fitness in checkpoint inhibitor resistant melanoma patients
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Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Part of Scientific Reports, 2026

• DOI for Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
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CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling

Naseri, Sedigheh; Mejia Cordova, Mariela; Wenthe, Jessica; Lövgren, Tanja et al.

Part of Journal of Cellular and Molecular Medicine, 2024

• DOI for CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling
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Tumor Microenvironment Gene Engineering with LOAd703 in Patients with Solid Malignancies: LOKON002 Phase I/IIb Clinical Trial

Hahn, Amanda; Irenaeus, Sandra; Sandin, Linda C.; Nordström, Clara et al.

Part of Clinical Cancer Research, p. 3157-3168, 2026

• DOI for Tumor Microenvironment Gene Engineering with LOAd703 in Patients with Solid Malignancies: LOKON002 Phase I/IIb Clinical Trial

LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial

Hamid, O.; Ekström-Rydén, Viktoria; Mehmi, I.; Wang, D. et al.

Part of Nature Communications, 2026

• DOI for LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial
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Reprogramming myeloid cells and restoring T cell fitness in checkpoint inhibitor resistant melanoma patients

Grauers Wiktorin, Hanna; Rydén, Viktoria; Ek, Ida; Eriksson, Emma et al.

Part of Biomarker Research, 2026

• DOI for Reprogramming myeloid cells and restoring T cell fitness in checkpoint inhibitor resistant melanoma patients
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Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Part of Scientific Reports, 2026

• DOI for Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
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CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling

Naseri, Sedigheh; Mejia Cordova, Mariela; Wenthe, Jessica; Lövgren, Tanja et al.

Part of Journal of Cellular and Molecular Medicine, 2024

• DOI for CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling
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LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001) results from arm 1 of a non-randomised, single-centre, phase 1/2 study

Musher, Benjamin L.; Rowinsky, Eric K.; Smaglo, Brandon G.; Abidi, Wasif et al.

Part of The Lancet Oncology, p. 488-500, 2024

• DOI for LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001) results from arm 1 of a non-randomised, single-centre, phase 1/2 study

Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models

Wenthe, Jessica; Eriksson, Emma; Hellström, Ann-Charlotte; Moreno, Rafael et al.

Part of Journal of Translational Medicine, 2023

• DOI for Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models
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Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

Sarén, Tina; Ramachandran, Mohanraj; Gammelgård, Gustav; Lövgren, Tanja et al.

Part of Clinical Cancer Research, p. 4139-4152, 2023

• DOI for Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
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The signaling and the metabolic differences of various CAR T cell designs

Razavi, Azadeh Sadat; Loskog, Angelica S.; Razi, Sepideh; Rezaei, Nima

Part of International Immunopharmacology, 2023

• DOI for The signaling and the metabolic differences of various CAR T cell designs

Donor-derived urologic cancers after renal transplantation: A retrospective non-randomized scientific analysis

Hellström, Vivan; Tufveson, Gunnar; Loskog, Angelica; Bengtsson, Mats et al.

Part of PLOS ONE, 2022

• DOI for Donor-derived urologic cancers after renal transplantation: A retrospective non-randomized scientific analysis
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Immune priming using DC- and T cell-targeting gene therapy sensitizes both treated and distant B16 tumors to checkpoint inhibition

Wenthe, Jessica; Naseri, Sedigheh; Hellström, Ann-Charlotte; Moreno, Rafael et al.

Part of MOLECULAR THERAPY-ONCOLYTICS, p. 429-442, 2022

• DOI for Immune priming using DC- and T cell-targeting gene therapy sensitizes both treated and distant B16 tumors to checkpoint inhibition
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Whole body FDG PET/MR for progression free and overall survival prediction in patients with relapsed/refractory large B-cell lymphomas undergoing CAR T-cell therapy

Sjöholm, Therese; Korenyushkin, Alexander; Gammelgård, Gustav; Sarén, Tina et al.

Part of Cancer Imaging, 2022

• DOI for Whole body FDG PET/MR for progression free and overall survival prediction in patients with relapsed/refractory large B-cell lymphomas undergoing CAR T-cell therapy
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A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

Mansoori, Sharmineh; Fryknäs, Mårten; Alvfors, Carina; Loskog, Angelica et al.

Part of Scientific Reports, 2021

• DOI for A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer
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Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes

Labani-Motlagh, Alireza; Naseri, Sedigheh; Wenthe, Jessica; Eriksson, Emma et al.

Part of MOLECULAR THERAPY-ONCOLYTICS, p. 508-518, 2021

• DOI for Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes
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Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up

Saellstrom, Sara; Sadeghi, Arian; Eriksson, Emma; Segall, Thomas et al.

Part of Frontiers in Veterinary Science, 2021

• DOI for Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up
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Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy

Wenthe, Jessica; Naseri, Sedigheh; Labani-Motlagh, Alireza; Enblad, Gunilla et al.

Part of Cancer Immunology and Immunotherapy, p. 2851-2865, 2021

• DOI for Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy
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Intratumoral immunostimulatory AdCD40L gene therapy in patients with advanced solid tumors.

Irenaeus, Sandra; Hellström, Vivan; Wenthe, Jessica; Krause, Johan et al.

Part of Cancer Gene Therapy, p. 1188-1197, 2021

• DOI for Intratumoral immunostimulatory AdCD40L gene therapy in patients with advanced solid tumors.

Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

Wenthe, Jessica; Naseri, Sedigheh; Hellström, Ann-Charlotte; Jernberg Wiklund, Helena et al.

Part of Cancer Gene Therapy, p. 948-959, 2020

• DOI for Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40
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Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Andersson, Claes; Selvin, Tove; Blom, Kristin; Rubin, Jenny et al.

Part of Scientific Reports, 2020

• DOI for Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway
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Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma.

Rowinsky, Eric K; Paner, Agne; Berdeja, Jesus G; Paba-Prada, Claudia et al.

Part of Investigational new drugs, p. 1448-1453, 2020

• DOI for Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma.

Evaluation of Diffusion-Weighted MRI and FDG-PET/CT to Assess Response to AdCD40L treatment in Metastatic Melanoma Patients

Schiza, Aglaia; Irenaeus, Sandra; Ortiz-Nieto, Francisco; Loskog, Angelica S. et al.

Part of Scientific Reports, 2019

• DOI for Evaluation of Diffusion-Weighted MRI and FDG-PET/CT to Assess Response to AdCD40L treatment in Metastatic Melanoma Patients
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Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients

Amini, Rose-Marie; Enblad, Gunilla; Hollander, Peter; Laszlo, S. et al.

Part of BMC Cancer, 2019

• DOI for Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients
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Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Blom, Kristin; Eriksson, Jenny; Berglund, Malin; Jarvius, Malin et al.

Part of BMC Research Notes, 2019

• DOI for Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition
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IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-beta, Collagen Type I, and PD-L1/PD-1

Eriksson, Emma; Milenova, Ioanna; Wenthe, Jessica; Moreno, Rafael et al.

Part of Journal of Immunology, p. 787-798, 2019

• DOI for IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-beta, Collagen Type I, and PD-L1/PD-1

Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients

Hoffmann, Jean-Marc; Schubert, Maria-Luisa; Wang, Lei; Hueckelhoven, Angela et al.

Part of Frontiers in Immunology, 2018

• DOI for Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients
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An anergic immune signature in the tumor microenvironment of classical Hodgkin lymphoma is associated with inferior outcome

Hollander, Peter; Rostgaard, Klaus; Ekström-Smedby, Karin; Molin, Daniel et al.

Part of European Journal of Haematology, p. 88-97, 2018

• DOI for An anergic immune signature in the tumor microenvironment of classical Hodgkin lymphoma is associated with inferior outcome
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A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia

Enblad, Gunilla; Karlsson, Hannah; Gammelgård, Gustav; Wenthe, Jessica et al.

Part of Clinical Cancer Research, p. 6185-6194, 2018

• DOI for A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia

Immunostimulatory gene therapy enhances PD-1 blockade antibody therapy in experimental lung cancer

Wenthe, Jessica; Eriksson, Emma; Hellström, Ann-Charlotte; Loskog, Angelica S.

Part of CANCER IMMUNOLOGY RESEARCH, 2018

• DOI for Immunostimulatory gene therapy enhances PD-1 blockade antibody therapy in experimental lung cancer

Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Schiza, Aglaia; Wenthe, Jessica; Mangsbo, Sara; Svensson, Emma et al.

Part of Journal of Translational Medicine, 2017

• DOI for Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients
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Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients

Irenaeus, Sandra; Schiza, Aglaia; Mangsbo, Sara M.; Wenthe, Jessica et al.

Part of Oncotarget, p. 78573-78587, 2017

• DOI for Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients
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An oncolytic virus targeting desmoplasia and immune activation in pancreatic cancer

Eriksson, Emma; Milenova, Ioanna; Wenthe, Jessica; Moreno, Rafael et al.

Part of Scandinavian Journal of Immunology, p. 335-335, 2017

Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus.

Svensson, Emma; Milenova, Ioanna; Wenthe, Jessica; Ståhle, Magnus et al.

Part of Clinical Cancer Research, p. 5846-5857, 2017

• DOI for Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus.

Distinct phenotype of CD19-specific CAR T cells generated from healthy donor vs. patient lymphocytes using either IL-7/IL-15 or IL-2

Hoffmann, J. -M; Stock, S.; Sellner, L.; Hueckelhoven, A. et al.

Part of Oncology Research and Treatment, p. 213-213, 2017

Preclinical Evaluation of AdVince, an Oncolytic Adenovirus Adapted for Treatment of Liver Metastases from Neuroendocrine Cancer

Yu, Di; Leja, Justyna; Loskog, Angelica S.; Hellman, Per et al.

Part of Neuroendocrinology, p. 54-66, 2017

• DOI for Preclinical Evaluation of AdVince, an Oncolytic Adenovirus Adapted for Treatment of Liver Metastases from Neuroendocrine Cancer

Adenovirus-mediated CD40L gene transfer increases teffector/tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Schiza, Aglaia; Wenthe, Jessica; Mangsbo, Sara; Eriksson, Emma et al.

Part of Scandinavian Journal of Immunology, p. 337-337, 2017

Immunological biomarkers correlate to survival in CAR19-treated patients

Lövgren, Tanja; Wenthe, Jessica; Karlsson, S. C. Hannah; Gammelgård, Gustav et al.

Part of Scandinavian Journal of Immunology, p. 337-337, 2017

Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion

Kaartinen, Tanja; Luostarinen, Annu; Maliniemi, Pilvi; Keto, Joni et al.

Part of Cytotherapy, p. 689-702, 2017

• DOI for Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion
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Donor Derived and BK Virus Positive Urologic Cancers After Renal Transplantation

Hellström, Vivan; Tufveson, Gunnar; Wallgren, AnnaCarin; Loskog, Angelica et al.

Part of American Journal of Transplantation, p. 472-472, 2017

• DOI for Donor Derived and BK Virus Positive Urologic Cancers After Renal Transplantation

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Blom, Kristin; Senkowski, Wojciech; Jarvius, Malin; Berglund, Malin et al.

Part of Immunopharmacology and immunotoxicology, p. 199-210, 2017

• DOI for The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Activating CD40 While Inhibiting IL6R Induces Cytokine Production without PDL1 Upregulation in DCs

Eriksson, Emma; Milenova, Ioanna; Wenthe, Jessica; Moreno, Rafael et al.

Part of Molecular Therapy, p. 54-54, 2017

Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment

Eriksson, Emma; Moreno, R; Milenova, I. Yoanna; Liljenfeldt, L et al.

Part of Gene Therapy, p. 92-103, 2017

• DOI for Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment
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Low il-2 concentration favors generation of early memory t cells over terminal eefectors during car t-cell expansion

Luostarinen, A.; Kaartinen, T.; Maliniernii, P.; Keto, J. et al.

Part of Cytotherapy, 2017

• DOI for Low il-2 concentration favors generation of early memory t cells over terminal eefectors during car t-cell expansion

Gemcitabine reduces MDSCs, tregs and TGF beta-1 while restoring the teff/treg ratio in patients with pancreatic cancer

Eriksson, Emma; Wenthe, Jessica; Irenaeus, Sandra; Loskog, Angelica et al.

Part of Journal of Translational Medicine, 2016

• DOI for Gemcitabine reduces MDSCs, tregs and TGF beta-1 while restoring the teff/treg ratio in patients with pancreatic cancer
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Plasma proteomics in CML patients before and after initiation of tyrosine kinase inhibitor therapy reveals induced Th1 immunity and loss of angiogenic stimuli

Söderlund, Stina; Christiansson, Lisa; Persson, Inger; Hjorth-Hansen, Henrik et al.

Part of Leukemia Research, p. 95-103, 2016

• DOI for Plasma proteomics in CML patients before and after initiation of tyrosine kinase inhibitor therapy reveals induced Th1 immunity and loss of angiogenic stimuli

An Oncolytic Adenovirus Gene Therapy Targeting Both Tumor Cell Survival and Desmoplasia in Pancreatic Cancer

Milenova, Ioanna; Eriksson, Emma; Moreno, Rafael; Alemany, Ramon et al.

Part of Molecular Therapy, 2016

Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients

Loskog, Angelica; Maleka, Aglaia; Mangsbo, Sara; Svensson, Emma et al.

Part of British Journal of Cancer, p. 872-880, 2016

• DOI for Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients

Plasma Proteomics In Chronic Myeloid Leukemia Patients Before And After Initiation Of Tyrosine Kinase Inhibitor Therapy Reveals Induced Th1 Immunity And Loss Of Angiogenic Stimuli

Söderlund, Stina; Christiansson, Lisa; Persson, Inger; Hjorth-Hansen, H. et al.

Part of Haematologica, p. 730-730, 2016

A Novel Oncolytic Adenovirus Expressing Tumor Microenvironment Stimulators to Evoke and Facilitate Anti-Tumor Immune Responses

Wenthe, Jessica; Eriksson, Emma; Milenova, Ioanna; Moreno, Rafael et al.

Part of Molecular Therapy, 2016

T cell stimulation with different cytokines results in distinct phenotypes and cytotoxic activity of CD19-specific CART cells

Hoffmann, J. -M; Gern, U.; Wang, L.; Kleist, C. et al.

Part of Oncology Research and Treatment, p. 136-136, 2016

• DOI for T cell stimulation with different cytokines results in distinct phenotypes and cytotoxic activity of CD19-specific CART cells

CD19-targeting third generation CAR T cells for relapsed and refractory lymphoma and leukemia: report from the Swedish phase Ulla trial

Enblad, Gunilla; Karlsson, Hannah; Wikström, Kristina I.; Essand, Magnus et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2016

• DOI for CD19-targeting third generation CAR T cells for relapsed and refractory lymphoma and leukemia: report from the Swedish phase Ulla trial

A Clinical Trial Using Third Generation CD19 Targeting CAR T Cells for Relapsed Lymphoma and Leukemia

Enblad, Gunilla; Karlsson, Hannah; Wenthe, Jessica; Wikström, Kristina I. et al.

Part of Molecular Therapy, 2016

Prognostic Implications Of An Active, Innate Or Anergic Immune Response In The Hodgkin Lymphoma Tumor Microenvironment

Hollander, Peter; Rostgaard, K.; Smedby, K. E.; Molin, Daniel et al.

Part of Haematologica, p. 3-3, 2016

CD40L/4-1BBL-expressing oncolytic adenovirus (LOAd703) stimulates human dendritic cell production of Th1 cytokines and antigen-specific T cells

Svensson, Emma; Milenova, I. Yoanna; Moreno, R.; Alemany, R. et al.

Part of Human Gene Therapy, 2015

CD40L and 4-1BBL immunostimulating gene therapy reduces myeloid-derived suppressor cells (MDSCs) while promoting T and NK cell activation

Svensson, Emma; Wenthe, Jessica; Milenova, I. Yoanna; Moreno, R. et al.

Part of Human Gene Therapy, 2015

Immunostimulatory Gene Therapy Using Oncolytic Viruses as Vehicles

Loskog, Angelica

Part of Viruses, p. 5780-5791, 2015

• DOI for Immunostimulatory Gene Therapy Using Oncolytic Viruses as Vehicles
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Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors

Karlsson, Hannah; Svensson, Emma; Gigg, Camilla; Jarvius, Malin et al.

Part of PLOS ONE, 2015

• DOI for Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors
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Immunotherapy with a CD40L/4-1BBL double-armed oncolytic adenovirus drives Th1 immunity and control tumor progression in a pancreas cancer model

Svensson, Emma; Milenova, Ioanna; Moreno, Rafael; Alemany, Ramon et al.

Part of Cancer Research, 2015

• DOI for Immunotherapy with a CD40L/4-1BBL double-armed oncolytic adenovirus drives Th1 immunity and control tumor progression in a pancreas cancer model

The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses

Christiansson, Lisa; Söderlund, Stina; Mangsbo, Sara; Hjorth-Hansen, Henrik et al.

Part of Molecular Cancer Therapeutics, p. 1181-1191, 2015

• DOI for The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses

VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-κB-induced endothelial activation

Huang, Hua; Langenkamp, Elise; Georganaki, Maria; Loskog, Angelica et al.

Part of The FASEB Journal, p. 227-238, 2015

• DOI for VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-κB-induced endothelial activation

Increased TACE (Tumor necrosis factor-alpha +/--converting enzyme; ADAM17) Activity Associates with Decreased CD62L Expression, Increased Soluble CD62L Plasma Levels and Predicts Molecular Response to Nilotinib Therapy in Patients with Early Chronic Phase Chronic Myelogenous Leukemia (CML-CP): Results from an ENEST1st Substudy

Sopper, Sieghart; Mustjoki, Satu; Loskog, Angelica; Gjertsen, Bjorn T. et al.

Part of Blood, 2015

Insertion of exogenous epitopes in the E3-19K of oncolytic adenoviruses to enhance TAP-independent presentation and immunogenicity

Rodriguez-Garcia, A.; Svensson, Emma; Gil-Hoyos, R.; Fajardo, C. A. et al.

Part of Gene Therapy, p. 596-601, 2015

• DOI for Insertion of exogenous epitopes in the E3-19K of oncolytic adenoviruses to enhance TAP-independent presentation and immunogenicity

Third Generation CD19-CAR T Cells for Relapsed and Refractory Lymphoma and Leukemia Report from the Swedish Phase I/IIa Trial

Enblad, Gunilla; Karlsson, Hannah; Wikström, Kristina; Essand, Magnus et al.

Part of Blood, 2015

Development of Gene Transfer Technology

Svensson, Emma; Moreno, R.; Milenova, Ioanna; Christiansson, Lisa et al.

Part of Human Gene Therapy, 2014

AdCD40L Immunostimulatory Gene Therapy in Combination with Cyclophosphamide Prolongs 6-Months Survival in a Phase I/II Trial for Malignant Melanoma

Loskog, Angelica; Maleka, Aglaia; Mangsbo, Sara; Svensson, Emma et al.

Part of Molecular Therapy, 2014

• DOI for AdCD40L Immunostimulatory Gene Therapy in Combination with Cyclophosphamide Prolongs 6-Months Survival in a Phase I/II Trial for Malignant Melanoma

The use of multiplex platforms for absolute and relative protein quantification of clinical material

Christiansson, Lisa; Mustjoki, Satu; Simonsson, Bengt; Olsson-Strömberg, Ulla et al.

Part of EuPA Open Proteomics, p. 37-47, 2014

• DOI for The use of multiplex platforms for absolute and relative protein quantification of clinical material

CD62L Expression on T Cells is Decreased in Patients with Early Chronic Phase Chronic Myelogenous Leukemia (CML-CP) and Predicts Response to Therapy with Frontline Nilotinib

Sopper, S.; Mustjoki, S.; Loskog, Angelica; Gjertsen, B. et al.

Part of Haematologica, p. 64-64, 2014

Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo

Sandin, Linda C.; Eriksson, Fredrik; Ellmark, Peter; Loskog, Angelica S. I. et al.

Part of Oncoimmunology, 2014

• DOI for Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo

Immunostimulating Gene Therapy Using an Oncolytic Adenovirus Armed with CD40 Ligand Potently Kill Tumor Cells, Activates Dendritic Cells and Induces T Cell Responses

Svensson, Emma; Moreno, Rafael; Milenova, Ioanna; Christiansson, Lisa et al.

Part of Molecular Therapy, 2014

Antigen Signaling Enhances Proliferation and Cytotoxic Capacity of CD19-Targeting CD28/4-1BB CAR T Cells During Expansion Without Inducing Exhaustion

Karlsson, Hannah; Gigg, Camilla; Svensson, Emma; Larsson, Rolf et al.

Part of Molecular Therapy, 2014

Intranasal Delivery of CNS-Retargeted Human Mesenchymal Stromal Cells Prolongs Treatment Efficacy of Experimental Autoimmune Encephalomyelitis

Fransson, Moa; Piras, Elena; Wang, Hao; Burman, Joachim et al.

Part of Immunology, p. 431-441, 2014

• DOI for Intranasal Delivery of CNS-Retargeted Human Mesenchymal Stromal Cells Prolongs Treatment Efficacy of Experimental Autoimmune Encephalomyelitis

Tim-3 and PD-1: Regulators of adaptive immunity in multiple sclerosis

Burman, Joachim; Svensson, Emma; Fransson, Moa; Loskog, Angelica et al.

Part of Journal of Neuroimmunology, p. 141-141, 2014

• DOI for Tim-3 and PD-1: Regulators of adaptive immunity in multiple sclerosis

CAR T Cells Express CD40L and Activates Human Dendritic Cells

Karlsson, Hannah; Gustafsson, Wictor; Olsson-Strömberg, Ulla; Savoldo, Barbara et al.

Part of Molecular Therapy, 2014

Assessing tissue damage in multiple sclerosis: a biomarker approach

Burman, Joachim; Zetterberg, H; Fransson, Moa; Loskog, Angelica SI. et al.

Part of Acta Neurologica Scandinavica, p. 81-89, 2014

• DOI for Assessing tissue damage in multiple sclerosis: a biomarker approach

Enhanced therapeutic anti-tumor immunity induced by co-administration of 5-fluorouracil and adenovirus expressing CD40 ligand

Liljenfeldt, Lina; Gkirtzimanaki, Katerina; Vyrla, Dimitra; Svensson, Emma et al.

Part of Cancer Immunology and Immunotherapy, p. 273-282, 2014

• DOI for Enhanced therapeutic anti-tumor immunity induced by co-administration of 5-fluorouracil and adenovirus expressing CD40 ligand

The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention

Burman, Joachim; Svensson, Emma; Fransson, Moa; Loskog, Angelica S I et al.

Part of Journal of Neuroimmunology, p. 153-159, 2014

• DOI for The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention

CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes

Liljenfeldt, Lina; Dieterich, Lothar C.; Dimberg, Anna; Mangsbo, Sara M. et al.

Part of Cancer Gene Therapy, p. 95-102, 2014

• DOI for CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes

Reduced Expression of CD62L Is Associated with Increased ADAM1 7 Activity and Predicts Molecular Response to Nilotinib Therapy in Patients with Early Chronic Phase Chronic Myelogenous Leukemia (CML-CP)

Sopper, Sieghart; Mustjoki, Satu; Loskog, Angelica; Gjertsen, Bjorn T. et al.

Part of Blood, 2014

Increased Level of Myeloid-Derived Suppressor Cells, Programmed Death Receptor Ligand 1/Programmed Death Receptor 1, and Soluble CD25 in Sokal High Risk Chronic Myeloid Leukemia

Christiansson, Lisa; Söderlund, Stina; Svensson, Emma; Mustjoki, Satu et al.

Part of PLOS ONE, 2013

• DOI for Increased Level of Myeloid-Derived Suppressor Cells, Programmed Death Receptor Ligand 1/Programmed Death Receptor 1, and Soluble CD25 in Sokal High Risk Chronic Myeloid Leukemia
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alpha B-Crystallin regulates expansion of CD11b(+)Gr-1(+) immature myeloid cells during tumor progression

Dieterich, Lothar C; Schiller, Petter; Huang, Hua; Wawrousek, Eric F et al.

Part of The FASEB Journal, p. 151-162, 2013

• DOI for alpha B-Crystallin regulates expansion of CD11b(+)Gr-1(+) immature myeloid cells during tumor progression

T-cell responses after haematopoietic stem cell transplantation for aggressive relapsing-remitting multiple sclerosis

Burman, Joachim; Fransson, Moa; Tötterman, Thomas H.; Fagius, Jan et al.

Part of Immunology, p. 211-219, 2013

• DOI for T-cell responses after haematopoietic stem cell transplantation for aggressive relapsing-remitting multiple sclerosis

Treatment Efficacy and Immune Stimulation by AdCD40L Gene Therapy of Spontaneous Canine Malignant Melanoma

Westberg, Sara; Sadeghi, Arian; Svensson, Emma; Segall, Thomas et al.

Part of Journal of immunotherapy (1997), p. 350-358, 2013

• DOI for Treatment Efficacy and Immune Stimulation by AdCD40L Gene Therapy of Spontaneous Canine Malignant Melanoma

Enhanced proliferation and tyrosine kinase pathway engagement in 4-1BB domain-containing CAR T cells

Karlsson, H.; Svensson, E.; Lindqvist, C.; Hambardzumyan, K. et al.

Part of Human Gene Therapy, 2013

AdCD40L immunostimulatory gene therapy shifts the MDSC- and macrophage profiles and promotes T cell infiltration in the tumor microenvironment

Liljenfeldt, Lina; Svensson, E.; Huang, H.; Dieterich, L. et al.

Part of Human Gene Therapy, 2013

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

Fransson, Moa; Piras, Elena; Burman, Joachim; Nilsson, Berith et al.

Part of Journal of Neuroinflammation, p. 112, 2012

• DOI for CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
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Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4

Dias, J D; Hemminki, O; Diaconu, I; Hirvinen, M et al.

Part of Gene Therapy, p. 988-998, 2012

• DOI for Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4

Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Diaconu, Iulia; Cerullo, Vincenzo; Hirvinen, Mari L M; Escutenaire, Sophie et al.

Part of Cancer Research, p. 2327-2338, 2012

• DOI for Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Both CD4(+) FoxP3(+) and CD4(+) FoxP3(-) T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro.

Lindqvist, Camilla; Christiansson, Lisa; Thörn, Ingrid; Mangsbo, Sara et al.

Part of Immunology, p. 296-306, 2011

• DOI for Both CD4(+) FoxP3(+) and CD4(+) FoxP3(-) T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro.

Genetically Engineered Cells Target CNS and Cure Experimental Autoimmune Encephalomyelitis

Fransson, Moa; Piras, Elena; Wang, H; Rasmussen Duprez, I et al.

Part of Human Gene Therapy, p. 1381-1381, 2010

• DOI for Genetically Engineered Cells Target CNS and Cure Experimental Autoimmune Encephalomyelitis

AdCD40L Immunogene Therapy for Bladder Carcinoma: The First Phase I/IIa Trial

Malmström, Per-Uno; Loskog, Angelica S. I.; Lindqvist, Camilla A.; Mangsbo, Sara M. et al.

Part of Clinical Cancer Research, p. 3279-3287, 2010

• DOI for AdCD40L Immunogene Therapy for Bladder Carcinoma: The First Phase I/IIa Trial

Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy

Mangsbo, Sara; Sandin, Linda; Anger, Kerstin; Korman, Alan et al.

Part of Journal of immunotherapy (1997), p. 225-235, 2010

• DOI for Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy

T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies

Lindqvist, Camilla A.; Christiansson, Lisa H.; Simonsson, Bengt; Enblad, Gunilla et al.

Part of Immunology, p. 371-376, 2010

• DOI for T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies

T regulatory cells lacking CD25 are increased in MS during relapse

Fransson, Moa; Burman, Joachim; Lindqvist, Camilla; Atterby, Christina et al.

Part of Autoimmunity, p. 590-597, 2010

• DOI for T regulatory cells lacking CD25 are increased in MS during relapse

The T-cell pool is anergized in patients with multiple sclerosis in remission

Fransson, Moa; Liljenfeldt, Lina S.; Fagius, Jan; Tötterman, Thomas et al.

Part of Immunology, p. 92-101, 2009

• DOI for The T-cell pool is anergized in patients with multiple sclerosis in remission

Midgut carcinoid patients display increased numbers of regulatory T cells in peripheral blood with infiltration into tumor tissue

Vikman, Sofia; Sommaggio, Roberta; De La Torre, Manuel; Öberg, Kjell et al.

Part of Acta Oncologica, p. 391-400, 2009

• DOI for Midgut carcinoid patients display increased numbers of regulatory T cells in peripheral blood with infiltration into tumor tissue
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Local AdCD40L gene therapy is effective for disseminated murine experimental cancer by breaking T-cell tolerance and inducing tumor cell growth inhibition

Lindqvist, Camilla; Sandin, Linda; Fransson, Moa; Loskog, Angelica

Part of Journal of immunotherapy (1997), p. 785-792, 2009

Adenovirus delivery of human CD40 ligand gene confers direct therapeutic effects on carcinomas

Vardouli, Lina; Lindqvist, Camilla; Vlahou, Katerina; Loskog, Angelica et al.

Part of Cancer Gene Therapy, p. 848-860, 2009

• DOI for Adenovirus delivery of human CD40 ligand gene confers direct therapeutic effects on carcinomas

Efficient adenovector CD40 ligand immunotherapy of canine malignant melanoma

von Euler, Henrik; Sadeghi, Arian; Carlsson, Björn; Rivera, Patricio et al.

Part of Journal of immunotherapy (1997), p. 377-384, 2008

• DOI for Efficient adenovector CD40 ligand immunotherapy of canine malignant melanoma

CpG Therapy is Superior to BCG in an Orthotopic Bladder Cancer Model and Generates CD4+ T-cell Immunity

Mangsbo, Sara M; Ninalga, Christina; Essand, Magnus; Loskog, Angelica et al.

Part of Journal of immunotherapy (1997), p. 34-42, 2008

• DOI for CpG Therapy is Superior to BCG in an Orthotopic Bladder Cancer Model and Generates CD4+ T-cell Immunity

CpG oligonucleotides demonstrate increased therapeutic efficacy compared to BCG in an aggressive orthotopic bladder cancer model

Ninalga, Christina; Mangsbo, Sara; Loskog, Angelica; Essand, Magnus et al.

Part of Journal of immunotherapy (1997), p. 34-42, 2008

• DOI for CpG oligonucleotides demonstrate increased therapeutic efficacy compared to BCG in an aggressive orthotopic bladder cancer model

Enhanced CD28 signaling may be a common mechanism underlying resistance to regulation - Reply

Loskog, Angelica; Brenner, M. K.

Part of Leukemia, p. 175-175, 2007

• DOI for Enhanced CD28 signaling may be a common mechanism underlying resistance to regulation - Reply

Human bladder carcinoma is dominated by T-regulatory cells and Th1 inhibitory cytokines

Loskog, Angelica; Ninalga, Christina; Paul-Wetterberg, Gabriella; de la Torre, Manuel et al.

Part of Journal of Urology, p. 353-358, 2007

• DOI for Human bladder carcinoma is dominated by T-regulatory cells and Th1 inhibitory cytokines

CD40L - a multipotent molecule for tumor therapy

Loskog, Angelica; Tötterman, Thomas

Part of Endocrine, metabolic & immune disorders - drug targets, p. 23-28, 2007

• DOI for CD40L - a multipotent molecule for tumor therapy

Dendritic cells engineered to express CD40L continuously produce IL12 and resist negative signals from Tr1/Th3 dominated tumors

Loskog, Angelica; Ninalga, Christina; Tötterman, Thomas H.

Part of Cancer Immunology and Immunotherapy, p. 588-597, 2006

• DOI for Dendritic cells engineered to express CD40L continuously produce IL12 and resist negative signals from Tr1/Th3 dominated tumors

Adenovirus-Mediated CD40 Ligand Therapy Induces Tumor Cell Apoptosis and Systemic Immunity in the TRAMP-C2 Mouse Prostate Cancer Model

Dzojic, Helena; Loskog, Angelica; Tötterman, Thomas H.; Essand, Magnus

Part of The Prostate, p. 831-838, 2006

• DOI for Adenovirus-Mediated CD40 Ligand Therapy Induces Tumor Cell Apoptosis and Systemic Immunity in the TRAMP-C2 Mouse Prostate Cancer Model

Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells

Loskog, Angelica; Giandomenico, Valeria; Rossig, C.; Pule, M. et al.

Part of Leukemia, p. 1819-1828, 2006

• DOI for Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells

Optimization of the MB49 mouse bladder cancer model for adenoviral gene therapy

Loskog, Angelica; Ninalga, Christina; Hedlund, Titti; Alimohammadi, Mohammad et al.

Part of Laboratory Animals, p. 384-393, 2005

• DOI for Optimization of the MB49 mouse bladder cancer model for adenoviral gene therapy

CpG oligonucleotide therapy cures subcutaneous and orthotopic tumors and evokes protective immunity in murine bladder cancer

Ninalga, Christina; Loskog, Angelica; Klevenfeldt, Magdalena; Essand, Magnus et al.

Part of Journal of immunotherapy (1997), p. 20-27, 2005

The immunotherapy of prostate and bladder cancer

Tötterman, Thomas H.; Loskog, Angelica; Essand, Magnus

Part of BJU International, p. 728-735, 2005

• DOI for The immunotherapy of prostate and bladder cancer

AdCD40L gene therapy counteracts T regulatory cells and cures aggressive tumors in an orthotopic bladder cancer model

Loskog, Angelica S.; Fransson, Moa E.; Tötterman, Thomas H.

Part of Clinical Cancer Research, p. 8816-8821, 2005

• DOI for AdCD40L gene therapy counteracts T regulatory cells and cures aggressive tumors in an orthotopic bladder cancer model

Adenovirus CD40 Ligand Gene Therapy Counteracts Immune Escape Mechanisms in the Tumor Microenvironment

Loskog, Angelica; Dzojic, Helena; Vikman, Sofia; Ninalga, Christina et al.

Part of Journal of Immunology, p. 7200-7205, 2004

Human urinary bladder carcinomas express adenovirus attachment and internalization receptors

Loskog, Angelica; Hedlund, Titti; Wester, Kenneth; de la Torre, Manuel et al.

Part of Gene Therapy, p. 547-553, 2002

• DOI for Human urinary bladder carcinomas express adenovirus attachment and internalization receptors

In vitro activation of cancer patient-derived dendritic cells by tumor cells genetically modified to express CD154

Loskog, Angelica; Tötterman, Thomas H.; Böhle, Andreas; Brandau, Sven

Part of Cancer Gene Therapy, p. 846-853, 2002

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

Labani-Motlagh, Alireza; Ashja-Mahdavi, Mehrnoush; Loskog, Angelica S.

Part of Frontiers in Immunology, 2020

• DOI for The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses
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CAR T-Cell Therapy: The Role of Physical Barriers and Immunosuppression in Lymphoma

Enblad, Gunilla; Karlsson, Hannah; Loskog, Angelica S. I.

Part of Human Gene Therapy, p. 498-505, 2015

• DOI for CAR T-Cell Therapy: The Role of Physical Barriers and Immunosuppression in Lymphoma

Genetically engineered T cells for the treatment of cancer

Essand, Magnus; Loskog, Angelica S I

Part of Journal of Internal Medicine, p. 166-181, 2013

• DOI for Genetically engineered T cells for the treatment of cancer

T Regulatory Cells in B-Cell Malignancy: Tumor Support or Kiss of Death?

Lindqvist, Camilla A; Loskog, Angelica Si

Part of Immunology, p. 255-260, 2012

• DOI for T Regulatory Cells in B-Cell Malignancy: Tumor Support or Kiss of Death?

AdCD40L: Crossing the Valley of Death?

Ullenhag, Gustav; Loskog, Angelica S I

Part of International Reviews of Immunology, p. 289-298, 2012

• DOI for AdCD40L: Crossing the Valley of Death?

The Janus faces of CD40 in cancer

Loskog, Angelica; Eliopoulos, Aristides

Part of Seminars in Immunology, p. 301-307, 2009

• DOI for The Janus faces of CD40 in cancer

Genetic engineering - a new era for cancer immunotherapy?

Loskog, Angelica; Tötterman, Thomas H.

Part of Current Cancer Therapy Reviews, p. 194-198, 2007

Nya fotspår

Loskog, Angelica

Part of Skor är huvudsaken, p. 20-21, Uppsala universitet, 2013

Genetic engineering for cancer immunotherapy

Loskog, Angelica

Part of Gene Therapy and Cancer Research Focus, Nova Biomedical Books, 2008

CD40L-based cancer therapy: Expert commentary

Loskog, Angelica; Eliopoulos, Aris

Part of New Gene Therapy and Cancer Research, Nova Biomedical Books, 2008

Imatinib or dasatinib treatment of chronic myeloid leukemia reduces circulating myeloid-derived suppressor cells but increases their CD40 expression

Christiansson, Lisa; Söderlund, Stina; Hjorth-Hansen, Henrik; Höglund, Martin et al.

A Comparison of Multiplex Platforms for Absolute and Relative Protein Quantification

Christiansson, Lisa; Mustjoki, Satu; Loskog, Angelica S I; Mangsbo, Sara

Human Mesenchymal stromal cells expressing a CNS-targeting receptor can be administrated intra nasally and cure expersimental autoimmune enchphlomyelitis

Fransson, Moa; Piras, E; Wang, H; Burman, Joachim et al.

Engineered T regulatory cells target CNS and suppress active EAE upon intra nasal delivery

Fransson, Moa; Piras, E; Wang, H; Burman, Joachim et al.

Safety of intratumoral immunostimulatory LOAd703 gene therapy in patients with advanced cancer

Irenaeus, Sandra; Wenthe, Jessica; Eriksson, Emma; Schiza, Aglaia et al.

Single-cell RNA analysis reveal subpopulations of CAR T cells correlating with response in lymphoma patients

Sarén, Tina; Ramachandran, Mohanraj; Gammelgård, Gustav; Lövgren, Tanja et al.

Immunological evaluation of immunostimulatory gene therapy targeting CD40/4-1BB in advanced cancer patients (LOKON002)

Wenthe, Jessica; Eriksson, Emma; Naseri, Sedigheh; Sandin, Linda et al.

Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models

Wenthe, Jessica; Eriksson, Emma; Hellström, Ann-Charlotte; Moreno, Rafael et al.

LOAd703 Gene Engineering Induces Tumor Cell Immunogenicity and Enhances the Effect of Chemotherapy in Ovarian Cancer Models

Naseri, Sedigheh; Härdin, Jonas; Mejia Cordova, Mariela; Eriksson, Emma et al.