Ulrika Rosenström
Senior Lecturer/Associate Professor at Department of Medicinal Chemistry; Preparative Medicinal Chemistry
- Telephone:
- +46 18 471 42 97
- E-mail:
- ulrika.rosenstrom@ilk.uu.se
- Visiting address:
- Uppsala Biomedicinska Centrum, BMC, Husarg. 3
- Postal address:
- Box 574
751 23 UPPSALA
Biography
Ulrika received a Master of Science in Chemistry from Uppsala University in 1996 and was appointed as a scientist at Pharmacia and Upjohn. In 1999 she started her dissertation work in Medicinal Chemistry under Prof Anders Hallberg and in 2004 she became Doctor of Philosophy (Faculty of Pharmacy). In 2005 she was appointed a position as researcher and lecturer at the Division of Organic Pharmaceutical Chemistry and 2007 she became Chemistry director and scientist at Cardoz AB, a small biotech company in preclinical and clinical phase. In 2011 she returned to Uppsala University as a researcher and senior lecturer. Her main research interests are: synthesis of peptides and pseudopeptides as novel PET-radiotracers, and design and synthesis of both drug-like and peptidomimetic enzyme inhibitors.

Publications
Recent publications
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Part of European Journal of Pharmaceutical Sciences, 2025
- DOI for Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
- Download full text (pdf) of Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
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Part of ACS Pharmacology & Translational Science, p. 3600-3612, 2025
- DOI for Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
- Download full text (pdf) of Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
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Part of EJNMMI Research, 2025
- DOI for A preclinical study on the influence of linkers in [68Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression
- Download full text (pdf) of A preclinical study on the influence of linkers in [68Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression
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Part of EJNMMI Radiopharmacy and Chemistry, 2025
- DOI for Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography
- Download full text (pdf) of Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography
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Part of ACS Omega, p. 18608-18616, 2024
- DOI for Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
- Download full text (pdf) of Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
All publications
Articles in journal
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Part of European Journal of Pharmaceutical Sciences, 2025
- DOI for Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
- Download full text (pdf) of Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
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Part of ACS Pharmacology & Translational Science, p. 3600-3612, 2025
- DOI for Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
- Download full text (pdf) of Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
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Part of EJNMMI Research, 2025
- DOI for A preclinical study on the influence of linkers in [68Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression
- Download full text (pdf) of A preclinical study on the influence of linkers in [68Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression
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Part of EJNMMI Radiopharmacy and Chemistry, 2025
- DOI for Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography
- Download full text (pdf) of Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography
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Part of ACS Omega, p. 18608-18616, 2024
- DOI for Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
- Download full text (pdf) of Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
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Part of International Journal of Molecular Sciences, 2024
- DOI for Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m
- Download full text (pdf) of Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m
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Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
Part of International Journal of Molecular Sciences, 2024
- DOI for Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
- Download full text (pdf) of Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
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Part of Molecular Medicine Reports, 2024
- DOI for Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker
- Download full text (pdf) of Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker
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Part of Cancers, 2023
- DOI for Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [Ga-68]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation
- Download full text (pdf) of Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [Ga-68]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation
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Part of Frontiers in Oncology, 2023
- DOI for 177Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry
- Download full text (pdf) of 177Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry
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Part of International Journal of Molecular Sciences, 2023
- DOI for Preclinical Evaluation of a Novel High-Affinity Radioligand [99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
- Download full text (pdf) of Preclinical Evaluation of a Novel High-Affinity Radioligand [99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
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Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands
Part of Pharmaceutics, 2022
- DOI for Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands
- Download full text (pdf) of Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands
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Part of Nuclear Medicine and Biology, p. 54-62, 2021
- DOI for Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1
- Download full text (pdf) of Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1
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Improved Radiolytic Stability of a 68Ga-labelled Collagelin Analogue for the Imaging of Fibrosis
Part of Pharmaceuticals, 2021
- DOI for Improved Radiolytic Stability of a 68Ga-labelled Collagelin Analogue for the Imaging of Fibrosis
- Download full text (pdf) of Improved Radiolytic Stability of a 68Ga-labelled Collagelin Analogue for the Imaging of Fibrosis
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Part of Pharmaceutics, 2020
- DOI for Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model
- Download full text (pdf) of Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model
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Part of ChemistryOpen, p. 325-337, 2020
- DOI for Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
- Download full text (pdf) of Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
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Part of Pharmaceutics, 2019
- DOI for Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer
- Download full text (pdf) of Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer
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Part of Pharmaceutics, 2019
- DOI for Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart
- Download full text (pdf) of Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart
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Part of Scientific Reports, 2019
- DOI for Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26
- Download full text (pdf) of Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26
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Part of Cancers, 2019
- DOI for Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer
- Download full text (pdf) of Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer
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Part of International Journal of Cancer, p. 3347-3358, 2019
- DOI for Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26
- Download full text (pdf) of Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26
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Part of Scientific Reports, 2018
- DOI for Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable by [Ga-68]Ga-DO3A-VS-Cys(40)- Exendin-4/PET
- Download full text (pdf) of Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable by [Ga-68]Ga-DO3A-VS-Cys(40)- Exendin-4/PET
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Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018
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GRPR-targeted radiotherapy using the Lu-177-labeled GRPR-antagonist DOTAGA-PEG(2)-RM26
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018
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Part of Contrast Media & Molecular Imaging, 2017
- DOI for High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
- Download full text (pdf) of High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
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Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017
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Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
Part of Acta Diabetologica, p. 1039-1045, 2017
- DOI for Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
- Download full text (pdf) of Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
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Fully automated GMP production of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 for clinical use
Part of American Journal of Nuclear Medicine and Molecular Imaging, p. 111-125, 2017
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Part of Molecular Pharmacology, p. 413-424, 2016
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Part of ACS Chemical Neuroscience, p. 1383-1392, 2016
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Part of Pharmaceuticals, 2016
- DOI for Feasibility of Multiple Examinations Using Ga-68-Labelled Collagelin Analogues: Organ Distribution in Rat for Extrapolation to Human Organ and Whole-Body Radiation Dosimetry
- Download full text (pdf) of Feasibility of Multiple Examinations Using Ga-68-Labelled Collagelin Analogues: Organ Distribution in Rat for Extrapolation to Human Organ and Whole-Body Radiation Dosimetry
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Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26.
Part of International journal of oncology, p. 2124-2134, 2016
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Part of Assay and drug development technologies, p. 180-193, 2016
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Ga-68/PET imaging and quantification of fibrosis using peptide-based tracers
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016
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Development of radiocobalt-labeled GRPR antagonist NOTA-PEG2-RM26.
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015
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Influence of chelators on targeting properties of In-111 and Ga-68 labeled GRPR antagonist
Part of Journal of labelled compounds & radiopharmaceuticals, 2015
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Part of Nuclear Medicine and Biology, p. 446-454, 2015
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Part of Journal of labelled compounds & radiopharmaceuticals, 2015
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Part of Journal of labelled compounds & radiopharmaceuticals, 2015
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Part of Molecules, p. 10455-10472, 2014
- DOI for The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin
- Download full text (pdf) of The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin
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Nonresonant microwave heated continuous flow synthesis in medicinal chemistry
Part of Abstracts of Papers of the American Chemical Society, 2014
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Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors
Part of Organic Process Research & Development, p. 1582-1588, 2014
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Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides
Part of ChemistryOpen, p. 256-263, 2014
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Part of Nuclear Medicine and Biology, p. 728-736, 2014
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Influence of chelators on biodistribution and targeting properties of GRPR antagonist
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014
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Part of Bioorganic & Medicinal Chemistry, p. 1992-2000, 2013
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Part of Journal of labelled compounds & radiopharmaceuticals, 2013
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Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships
Part of Bioorganic & Medicinal Chemistry, p. 6841-6849, 2008
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Part of Journal of Medicinal Chemistry, p. 6133-6137, 2006
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Short pseudopeptides containing turn scaffolds with high AT(2) receptor affinity
Part of Bioorganic & Medicinal Chemistry, p. 5963-5972, 2006
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Part of Journal of Medicinal Chemistry, p. 4009-4024, 2005
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Part of Journal of Medicinal Chemistry, p. 859-870, 2004
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Synthesis and AT2 receptor-binding properties of angiotensin II analogues
Part of Journal of Peptide Research, p. 194-201, 2004