Anna Orlova

Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking

Mestre Borras, Anna; Mehari, Hanna; Bitzios, Athanasios; Zelepukin, Ivan et al.

Part of Journal of Biological Engineering, 2026

• DOI for Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking
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The Use of Glycine-Containing Peptide-Based Chelators for Labeling with 99mTc Improves the Imaging Properties of EpCAM-Targeting Designed Ankyrin Repeat Ec1

Deyev, Sergey; Fominykh, Anastasia; Varvashenya, Ruslan; Yanovich, Gleb et al.

Part of Molecular Pharmaceutics, p. 2469-2480, 2026

• DOI for The Use of Glycine-Containing Peptide-Based Chelators for Labeling with 99mTc Improves the Imaging Properties of EpCAM-Targeting Designed Ankyrin Repeat Ec1

Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus

Kumar, Naveen; Bilinska, Adrianna; Menéndez, Elena; Läppchen, Tilman et al.

Part of ACS Pharmacology & Translational Science, p. 59-68, 2026

• DOI for Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus
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Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Tolmachev, Vladimir; Herlina, Amelinda Janice; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A. et al.

Part of International Journal of Molecular Sciences, 2026

• DOI for Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model
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Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2026

• DOI for Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging
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Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking

Mestre Borras, Anna; Mehari, Hanna; Bitzios, Athanasios; Zelepukin, Ivan et al.

Part of Journal of Biological Engineering, 2026

• DOI for Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking
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The Use of Glycine-Containing Peptide-Based Chelators for Labeling with 99mTc Improves the Imaging Properties of EpCAM-Targeting Designed Ankyrin Repeat Ec1

Deyev, Sergey; Fominykh, Anastasia; Varvashenya, Ruslan; Yanovich, Gleb et al.

Part of Molecular Pharmaceutics, p. 2469-2480, 2026

• DOI for The Use of Glycine-Containing Peptide-Based Chelators for Labeling with 99mTc Improves the Imaging Properties of EpCAM-Targeting Designed Ankyrin Repeat Ec1

Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus

Kumar, Naveen; Bilinska, Adrianna; Menéndez, Elena; Läppchen, Tilman et al.

Part of ACS Pharmacology & Translational Science, p. 59-68, 2026

• DOI for Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus
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Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Tolmachev, Vladimir; Herlina, Amelinda Janice; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A. et al.

Part of International Journal of Molecular Sciences, 2026

• DOI for Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model
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Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2026

• DOI for Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging
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Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir M. et al.

Part of ACS Pharmacology & Translational Science, p. 3600-3612, 2025

• DOI for Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
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Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Tolmachev, Vladimir M. et al.

Part of European Journal of Pharmaceutical Sciences, 2025

• DOI for Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
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Designed Ankyrin Repeat Protein-Mediated Peptide Nucleic Acid-Based Pretargeting: A Proof-of-Principle Study

Oroujeni, Maryam; Westerlund, Kristina; Papalanis, Eleftherios; van Deventer, Alexander et al.

Part of Journal of Nuclear Medicine, p. 1105-1111, 2025

• DOI for Designed Ankyrin Repeat Protein-Mediated Peptide Nucleic Acid-Based Pretargeting: A Proof-of-Principle Study

Affibody-Derived Drug Conjugates Targeting The Epidermal Growth Factor Receptor Are Potent And Specific Cytotoxic Agents

Rinne, Sara S.; Yin, Wen; Li, Ruonan; Ding, Haozhong et al.

Part of ACS Pharmacology & Translational Science, p. 3872-3885, 2025

• DOI for Affibody-Derived Drug Conjugates Targeting The Epidermal Growth Factor Receptor Are Potent And Specific Cytotoxic Agents
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Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Tolmachev, Vladimir M.; Bezverkhniaia, Ekaterina; Papalanis, Eleftherios; Muhammad, Abdullah Mujahid Bin et al.

Part of ACS Pharmacology & Translational Science, p. 3509-3522, 2025

• DOI for Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68
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Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.
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Phase I Clinical Study with the GRPR-Antagonist [^99mTc]Tc-DB8 for SPECT Imaging of Prostate Cancer: Does the Injected Peptide Mass Make a Difference?

Orlova, Anna; Rybina, Anastasia; Medvedeva, Anna; Zelchan, Roman et al.

Part of Pharmaceutics, 2025

• DOI for Phase I Clinical Study with the GRPR-Antagonist [^99mTc]Tc-DB8 for SPECT Imaging of Prostate Cancer: Does the Injected Peptide Mass Make a Difference?
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The Impact of the Injected Mass of the Gastrin-Releasing Peptide Receptor Antagonist on Uptake in Breast Cancer: Lessons from a Phase I Trial of [99mTc]Tc-DB8

Bragina, Olga; Chernov, Vladimir; Larkina, Mariia; Varvashenya, Ruslan et al.

Part of Pharmaceutics, 2025

• DOI for The Impact of the Injected Mass of the Gastrin-Releasing Peptide Receptor Antagonist on Uptake in Breast Cancer: Lessons from a Phase I Trial of [99mTc]Tc-DB8
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A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

Olaniran Håkansson, Esther; Zelepukin, Ivan V.; Obeid, Karim; Bitzios, Athanasios et al.

Part of EJNMMI Research, 2025

• DOI for A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression
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RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Kanellopoulos, Panagiotis; Bitzios, Athanasios; Zelepukin, Ivan; Bezverkhniaia, Ekaterina et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study
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Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study

Medvedeva, Anna; Chernov, Vladimir; Larkina, Maria; Rybina, Anastasiya et al.

Part of ACS Pharmacology & Translational Science, p. 736-747, 2025

• DOI for Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study
• Download full text (pdf) of Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study

Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Tolmachev, Vladimir M.; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A.; Rosly, Alia Hani et al.

Part of ACS Pharmacology & Translational Science, p. 706-717, 2025

• DOI for Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules
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Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [¹⁸F]MeTz-PEG2-RM26 for positron emission tomography

Kanellopoulos, Panagiotis; Lundmark, Fanny; Abouzayed, Ayman; Balestri, Lorenzo Jacopo Ilic et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [¹⁸F]MeTz-PEG2-RM26 for positron emission tomography
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First-in-human experience with GRPR antagonist [⁶⁸Ga]Ga-NOTA-PEG₂-RM26 in prostate and breast cancer patients using PET/CT

Bjareback, Annie; Jonmarker, Olof; Tzortzakakis, Antonios; Jussing, Emma et al.

Part of EJNMMI Research, 2025

• DOI for First-in-human experience with GRPR antagonist [⁶⁸Ga]Ga-NOTA-PEG₂-RM26 in prostate and breast cancer patients using PET/CT
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Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?

Kanellopoulos, Panagiotis; Yu, Quanyi; Abouzayed, Abouzayed; Bezverkhniaia, Ekaterina et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?
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Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile

Liu, Yongsheng; Oroujeni, Maryam; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 4038-4048, 2024

• DOI for Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile
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Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.

Zhang, Jie; Bodenko, Vitalina; Larkina, Maria; Bezverkhniaia, Ekaterina et al.

Part of Journal of Controlled Release, p. 468-478, 2024

• DOI for Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
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Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation

Oroujeni, Maryam; Carlqvist, Matilda; Ryer, Eva; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2024

• DOI for Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation
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Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts

Zhang, Jie; Rinne, Sara S.; Yin, Wen; Leitao, Charles Dahlsson et al.

Part of ACS Pharmacology & Translational Science, p. 3228-3240, 2024

• DOI for Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts
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Gastrin-releasing peptide receptor as theranostic target in estrogen-receptor positive breast cancer: A preclinical study of the theranostic pair [⁵⁵Co]Co- and [¹⁷⁷Lu]Lu-DOTA-RM26

Baun, Christina; Olsen, Birgitte Brinkmann; Alves, Carla Maria Lourenco; Ditzel, Henrik Jorn et al.

Part of Nuclear Medicine and Biology, 2024

• DOI for Gastrin-releasing peptide receptor as theranostic target in estrogen-receptor positive breast cancer: A preclinical study of the theranostic pair [⁵⁵Co]Co- and [¹⁷⁷Lu]Lu-DOTA-RM26

Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting

Westerlund, Kristina; Oroujeni, Maryam; Gestin, Maxime; Clinton, Jacob et al.

Part of ACS Pharmacology & Translational Science, p. 1595-1611, 2024

• DOI for Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting
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Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery

Nagy, Abel; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Landmark, Fredrika et al.

Part of ACS Omega, p. 36122-36133, 2024

• DOI for Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
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Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [^99mTc]Tc(CO)₃-(HE)₃-Ec1 for Visualization of EpCAM-Expressing Lung Cancer

Zelchan, Roman; Chernov, Vladimir; Medvedeva, Anna; Rybina, Anastasia et al.

Part of Cancers, 2024

• DOI for Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [^99mTc]Tc(CO)₃-(HE)₃-Ec1 for Visualization of EpCAM-Expressing Lung Cancer
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GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics

Obeid, Karim; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Mattsson, Adam et al.

Part of Pharmaceutics, 2024

• DOI for GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics
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Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with ¹⁷⁷Lu

Machulkin, Aleksei E.; Petrov, Stanislav A.; Bodenko, Vitalina; Larkina, Mariia S. et al.

Part of ACS Pharmacology & Translational Science, p. 1457-1473, 2024

• DOI for Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with ¹⁷⁷Lu

Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer

Kanellopoulos, Panagiotis; Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Rosenström, Ulrika et al.

Part of ACS Omega, p. 18608-18616, 2024

• DOI for Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
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Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion

Deyev, Sergey M.; Oroujeni, Maryam; Garousi, Javad; Graeslund, Torbjoern et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion
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Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m
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Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the ^99mTc-Based Imaging of HER2-Expressing Malignant Tumors

Larkina, Maria; Varvashenya, Ruslan; Yuldasheva, Feruza; Plotnikov, Evgenii et al.

Part of Molecular Pharmaceutics, p. 1919-1932, 2024

• DOI for Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the ^99mTc-Based Imaging of HER2-Expressing Malignant Tumors

Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology

Kanellopoulos, Panagiotis; Mattsson, Adam; Abouzayed, Ayman; Obeid, Karim et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2024

• DOI for Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology
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Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with Tc-99m and I-125

Tolmachev, Vladimir; Bodenko, Vitalina; Orlova, Anna; Schulga, Alexey et al.

Part of Oncology Letters, 2023

• DOI for Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with Tc-99m and I-125
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Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

Liu, Yongsheng; Xu, Tianqi; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Part of Cancers, 2023

• DOI for Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab
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Comparison of HER2-targeted affibody conjugates loaded with auristatin-and maytansine-derived drugs

Yin, Wen; Xu, Tianqi; Ding, Haozhong; Zhang, Jie et al.

Part of Journal of Controlled Release, p. 515-527, 2023

• DOI for Comparison of HER2-targeted affibody conjugates loaded with auristatin-and maytansine-derived drugs

Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity

Leitao, Charles Dahlsson; Borras, Anna Mestre; Xu, Tianqi; Oroujeni, Maryam et al.

Part of Journal of Controlled Release, p. 185-195, 2023

• DOI for Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity

Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Part of Nuclear Medicine and Biology, 2023

• DOI for Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3
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Preclinical Characterization of a Stabilized Gastrin-Releasing Peptide Receptor Antagonist for Targeted Cancer Theranostics

Abouzayed, Ayman; Kanellopoulos, Panagiotis; Gorislav, Alisa; Tolmachev, Vladimir et al.

Part of Biomolecules, 2023

• DOI for Preclinical Characterization of a Stabilized Gastrin-Releasing Peptide Receptor Antagonist for Targeted Cancer Theranostics
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Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [Ga-68]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation

Lundmark, Fanny; Abouzayed, Ayman; Rinne, Sara S.; Timofeev, Vasiliy et al.

Part of Cancers, 2023

• DOI for Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [Ga-68]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation
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Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer

Bragina, Olga; Chernov, Vladimir; Larkina, Mariia; Rybina, Anstasiya et al.

Part of Theranostics, p. 4858-4871, 2023

• DOI for Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer
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¹⁷⁷Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry

Abouzayed, Ayman; Seitova, Kamila; Lundmark, Fanny; Bodenko, Vitalina et al.

Part of Frontiers in Oncology, 2023

• DOI for ¹⁷⁷Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry
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Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Larkina, Mariia et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
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Synthesis, I-123-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures

Hasnowo, Lutfi A.; Larkina, Maria S.; Plotnikov, Evgenii; Bodenko, Vitalina et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Synthesis, I-123-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures
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The GRPR Antagonist [^99mTc]Tc-maSSS-PEG₂-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity

Abouzayed, Ayman; Borin, Jesper; Lundmark, Fanny; Rybina, Anastasiya et al.

Part of Diagnostics, 2023

• DOI for The GRPR Antagonist [^99mTc]Tc-maSSS-PEG₂-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity
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Phase I Trial of [Tc-99m]Tc-maSSS-PEG(2)-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors

Chernov, Vladimir; Rybina, Anastasiya; Zelchan, Roman; Medvedeva, Anna et al.

Part of Cancers, 2023

• DOI for Phase I Trial of [Tc-99m]Tc-maSSS-PEG(2)-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors
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Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model

Xu, Tianqi; Schulga, Alexey; Konovalova, Elena; Rinne, Sara S. et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model
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Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Liu, Yongsheng; Gueler, Rezan; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Part of Pharmaceutics, 2022

• DOI for Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis
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Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071

Liu, Yongsheng; Vorobyeva, Anzhelika; Orlova, Anna; Konijnenberg, Mark W. et al.

Part of Pharmaceutics, 2022

• DOI for Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071
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Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Part of Pharmaceutics, 2022

• DOI for Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3
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Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Xu, Tianqi; Zhang, Jie; Oroujeni, Maryam; Tretyakova, Maria S. et al.

Part of Pharmaceutics, 2022

• DOI for Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2
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Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

Liu, Yongsheng; Yu, Shengze; Xu, Tianqi; Bodenko, Vitalina et al.

Part of Pharmaceutics, 2022

• DOI for Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT
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Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart

Garousi, Javad; Xu, Tianqi; Liu, Yongsheng; Vorontsova, Olga et al.

Part of Pharmaceutics, 2022

• DOI for Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart
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Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules

Rinne, Sara S.; Yin, Wen; Borras, Anna Mestre; Abouzayed, Ayman et al.

Part of Biomedicines, 2022

• DOI for Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules
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Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands

Lundmark, Fanny; Olanders, Gustav; Rinne, Sara Sophie; Abouzayed, Ayman et al.

Part of Pharmaceutics, 2022

• DOI for Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands
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Direct In Vivo Comparison of ^99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy

Tolmachev, Vladimir; Bodenko, Vitalina; Oroujeni, Maryam; Deyev, Sergey et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Direct In Vivo Comparison of ^99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy
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Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts

Oroujeni, Maryam; Tano, Hanna; Vorobyeva, Anzhelika; Liu, Yongsheng et al.

Part of Journal of Nuclear Medicine, p. 1046-1051, 2022

• DOI for Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts

Phase I Trial of ^99mTc-(HE)₃-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer

Bragina, Olga; Chernov, Vladimir; Schulga, Alexey; Konovalova, Elena et al.

Part of Journal of Nuclear Medicine, p. 528-535, 2022

• DOI for Phase I Trial of ^99mTc-(HE)₃-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer

Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Liu, Yongsheng; Vorobyeva, Anzhelika; Xu, Tianqi; Orlova, Anna et al.

Part of Pharmaceutics, 2021

• DOI for Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain
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A method of drug delivery to tumors based on rapidly biodegradable drug-loaded containers

Parakhonskiy, Bogdan; Shilyagina, Natalia Yu; Gusliakova, Olga; Volovetskiy, Artur B. et al.

Part of Applied Materials Today, 2021

• DOI for A method of drug delivery to tumors based on rapidly biodegradable drug-loaded containers

Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model

Xu, Tianqi; Ding, Haozhong; Vorobyeva, Anzhelika; Oroujeni, Maryam et al.

Part of Cancers, 2021

• DOI for Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model
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Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein

Garousi, Javad; Ding, Haozhong; von Witting, Emma; Xu, Tianqi et al.

Part of Pharmaceutics, 2021

• DOI for Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein
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Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle

Garousi, Javad; von Witting, Emma; Borin, Jesper; Vorobyeva, Anzhelika et al.

Part of Biomaterials, 2021

• DOI for Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle
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Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

Ding, Haozhong; Xu, Tianqi; Zhang, Jie; Tolmachev, Vladimir et al.

Part of Pharmaceutics, 2021

• DOI for Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution
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The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy

Yin, Wen; Xu, Tianqi; Altai, Mohamed; Oroujeni, Maryam et al.

Part of Pharmaceutics, 2021

• DOI for The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy
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The Use of a Non-Conventional Long-Lived Gallium Radioisotope ⁶⁶Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR: 2377 Affibody Molecule

Oroujeni, Maryam; Xu, Tianqi; Gagnon, Katherine; Rinne, Sara S. et al.

Part of Pharmaceutics, 2021

• DOI for The Use of a Non-Conventional Long-Lived Gallium Radioisotope ⁶⁶Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR: 2377 Affibody Molecule
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Preclinical Evaluation of ^99mTc-Labeled GRPR Antagonists maSSS/SES-PEG₂-RM26 for Imaging of Prostate Cancer

Abouzayed, Ayman; Rinne, Sara S.; Sabahnoo, Hamideh; Sörensen, Jens et al.

Part of Pharmaceutics, 2021

• DOI for Preclinical Evaluation of ^99mTc-Labeled GRPR Antagonists maSSS/SES-PEG₂-RM26 for Imaging of Prostate Cancer
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Ga-66-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [Ga-66]Ga-NOTA-PEG(2)-RM26

Rinne, Sara S.; Abouzayed, Ayman; Gagnon, Katherine; Tolmachev, Vladimir et al.

Part of Scientific Reports, 2021

• DOI for Ga-66-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [Ga-66]Ga-NOTA-PEG(2)-RM26
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HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers

Rinne, Sara S.; Dahlsson Leitao, Charles; Abouzayed, Ayman; Vorobyeva, Anzhelika et al.

Part of Cancers, p. 4791-4791, 2021

• DOI for HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers
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Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting

Tano, Hanna; Oroujeni, Maryam; Vorobyeva, Anzhelika; Westerlund, Kristina et al.

Part of Cancers, 2021

• DOI for Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting
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Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Oroujeni, Maryam; Rinne, Sara S.; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Part of International Journal of Molecular Sciences, 2021

• DOI for Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake
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Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1

Deyev, Sergey M.; Xu, Tianqi; Liu, Yongsheng; Schulga, Alexey et al.

Part of Cancers, 2021

• DOI for Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1
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Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model

Xu, Tianqi; Vorobyeva, Anzhelika; Schulga, Alexey; Konovalova, Elena et al.

Part of Cancers, 2021

• DOI for Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model
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Phase I study of ^99mTc-ADAPT6, a scaffold protein-based probe for visualization of HER2 expression in breast cancer

Bragina, Olga; von Witting, Emma; Garousi, Javad; Zelchan, Roman et al.

Part of Journal of Nuclear Medicine, p. 493-499, 2021

• DOI for Phase I study of ^99mTc-ADAPT6, a scaffold protein-based probe for visualization of HER2 expression in breast cancer

Possibilities of radionuclide diagnostics of Her2-positive breast cancer using technetium-99m-labeled target molecules: the first experience of clinical use

Bragina, O. D.; Chernov, V. I.; Garbukov, E. Yu; Doroshenko, A. V. et al.

Part of Bûlleten' sibirskoj mediciny, p. 23-30, 2021

• DOI for Possibilities of radionuclide diagnostics of Her2-positive breast cancer using technetium-99m-labeled target molecules: the first experience of clinical use
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In vitro and in vivo evaluation of the radiochemical compound based on 99mtechnetium labelled DARPin9_29 for molecular visualization of malignancies overexpressing Her2/neu

Bragina, O. D.; Vorobyeva, Anzhelika; Tolmachev, Vladimir M.; Orlova, Anna et al.

Part of Medical Radiology and Radiation Safety, p. 37-41, 2020

• DOI for In vitro and in vivo evaluation of the radiochemical compound based on 99mtechnetium labelled DARPin9_29 for molecular visualization of malignancies overexpressing Her2/neu

Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer

Abouzayed, Ayman; Tano, Hanna; Nagy, Abel; Rinne, Sara S. et al.

Part of Pharmaceutics, 2020

• DOI for Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer
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Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches

Güler, Rezan; Svedmark, Siri Flemming; Abouzayed, Ayman; Orlova, Anna et al.

Part of Scientific Reports, 2020

• DOI for Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches
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HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution

Ding, Haozhong; Altai, Mohamed; Yin, Wen; Lindbo, Sarah et al.

Part of Pharmaceutics, 2020

• DOI for HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution
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Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules

Rinne, Sara S.; Xu, Tianqi; Leitao, Charles Dahlsson; Stahl, Stefan et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules
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Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

Lundmark, Fanny; Abouzayed, Ayman; Mitran, Bogdan; Rinne, Sara S. et al.

Part of Pharmaceutics, 2020

• DOI for Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model
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Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model.

Leitao, Charles Dahlsson; Rinne, Sara S.; Altai, Mohamed; Vorontsova, Olga et al.

Part of Pharmaceutics, 2020

• DOI for Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model.
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Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1

Vorobyeva, Anzhelika; Bezverkhniaia, Ekaterina; Konovalova, Elena; Schulga, Alexey et al.

Part of Molecules, 2020

• DOI for Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1
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Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer

Baun, Christina; Mitran, Bogdan; Rinne, Sara S.; Dam, Johan H. et al.

Part of Molecules, 2020

• DOI for Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer
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Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting

Myrhammar, Anders; Vorobyeva, Anzhelika; Westerlund, Kristina; Yoneoka, Shuichiro et al.

Part of Scientific Reports, 2020

• DOI for Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting
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Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Garousi, Javad; Orlova, Anna; Frejd, Fredrik Y.; Tolmachev, Vladimir

Part of EJNMMI Radiopharmacy and Chemistry, 2020

• DOI for Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1

Vorobyeva, Anzhelika; Konovalova, Elena; Xu, Tianqi; Schulga, Alexey et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1
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Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules

Rinne, Sara S.; Leitao, Charles Dahlsson; Saleh-nihad, Zahra; Mitran, Bogdan et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules
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Effect of a radiolabel biochemical nature on tumor-targeting properties of EpCAM-binding engineered scaffold protein DARPin Ec1

Deyev, Sergey M.; Vorobyeva, Anzhelika; Schulga, Alexey; Abouzayed, Ayman et al.

Part of International Journal of Biological Macromolecules, p. 216-225, 2020

• DOI for Effect of a radiolabel biochemical nature on tumor-targeting properties of EpCAM-binding engineered scaffold protein DARPin Ec1
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Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111

Rinne, Sara S.; Leitao, Charles Dahlsson; Mitran, Bogdan; Bass, Tarek Z. et al.

Part of Scientific Reports, 2019

• DOI for Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111
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Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of ⁶⁸Ga-Labeled Tracers

Dahlsson Leitao, Charles; Rinne, Sara S.; Mitran, Bogdan; Vorobyeva, Anzhelika et al.

Part of International Journal of Molecular Sciences, 2019

• DOI for Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of ⁶⁸Ga-Labeled Tracers
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Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody-DM1 Drug Conjugates

Ding, Haozhong; Altai, Mohamed; Rinne, Sara S.; Vorobyeva, Anzhelika et al.

Part of Cancers, 2019

• DOI for Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody-DM1 Drug Conjugates
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Potent and specific fusion toxins consisting of a HER2-binding, ABD-derived affinity protein, fused to truncated versions of Pseudomonas exotoxin A

Liu, Hao; Lindbo, Sarah; Ding, Haozhong; Altai, Mohamed et al.

Part of International Journal of Oncology, p. 309-319, 2019

• DOI for Potent and specific fusion toxins consisting of a HER2-binding, ABD-derived affinity protein, fused to truncated versions of Pseudomonas exotoxin A

Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart

Oroujeni, Maryam; Abouzayed, Ayman; Lundmark, Fanny; Mitran, Bogdan et al.

Part of Pharmaceutics, 2019

• DOI for Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart
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Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer

Abouzayed, Ayman; Yim, Cheng-Bin; Mitran, Bogdan; Rinne, Sara S. et al.

Part of Pharmaceutics, 2019

• DOI for Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer
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Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26

Mitran, Bogdan; Thisgaard, Helge; Rinne, Sara S.; Dam, Johan Hygum et al.

Part of Scientific Reports, 2019

• DOI for Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26
• Download full text (pdf) of Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26

Increase in negative charge of ⁶⁸Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody molecules

Rinne, Sara S.; Leitao, Charles Dahlsson; Gentry, Joshua; Mitran, Bogdan et al.

Part of Scientific Reports, 2019

• DOI for Increase in negative charge of ⁶⁸Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody molecules
• Download full text (pdf) of Increase in negative charge of ⁶⁸Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody molecules

Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

Garousi, Javad; Huizing, Fokko J.; Vorobyeva, Anzhelika; Mitran, Bogdan et al.

Part of Scientific Reports, 2019

• DOI for Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts
• Download full text (pdf) of Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

Optimal composition and position of histidine-containing tags improves biodistribution of Tc-99m-labeled DARP in G3

Vorobyeva, Anzhelika; Schulga, Alexey; Konovalova, Elena; Guler, Rezan et al.

Part of Scientific Reports, 2019

• DOI for Optimal composition and position of histidine-containing tags improves biodistribution of Tc-99m-labeled DARP in G3
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Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of hepatic uptake

Rosestedt, Maria; Andersson, Ken G.; Rinne, Sara S.; Leitao, Charles Dahlsson et al.

Part of Scientific Reports, 2019

• DOI for Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of hepatic uptake
• Download full text (pdf) of Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of hepatic uptake

Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging

Vorobyeva, Anzhelika; Schulga, Alexey; Rinne, Sara S.; Günther, Tyran et al.

Part of International Journal of Molecular Sciences, 2019

• DOI for Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging
• Download full text (pdf) of Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging

Comparison of tumor-targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2

Vorobyeva, Anzhelika; Schulga, Alexey; Konovalova, Elena; Güler, Rezan et al.

Part of International Journal of Oncology, p. 1209-1220, 2019

• DOI for Comparison of tumor-targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2
• Download full text (pdf) of Comparison of tumor-targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2

Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer

Mitran, Bogdan; Varasteh, Zohreh; Abouzayed, Ayman; Rinne, Sara S. et al.

Part of Cancers, 2019

• DOI for Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer
• Download full text (pdf) of Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer

Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26

Mitran, Bogdan; Rinne, Sara S.; Konijnenberg, Mark W.; Maina, Theodosia et al.

Part of International Journal of Cancer, p. 3347-3358, 2019

• DOI for Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26
• Download full text (pdf) of Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26

Selection of the optimal macrocyclic chelators for labeling with ¹¹¹In and ⁶⁸Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT6

von Witting, Emma; Garousi, Javad; Lindbo, Sarah; Vorobyeva, Anzhelika et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 109-120, 2019

• DOI for Selection of the optimal macrocyclic chelators for labeling with ¹¹¹In and ⁶⁸Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT6
• Download full text (pdf) of Selection of the optimal macrocyclic chelators for labeling with ¹¹¹In and ⁶⁸Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT6

Site-specific conjugation of recognition tags to trastuzumab for peptide nucleic acid-mediated radionuclide HER2 pretargeting

Westerlund, Kristina; Vorobyeva, Anzhelika; Mitran, Bogdan; Orlova, Anna et al.

Part of Biomaterials, p. 73-85, 2019

• DOI for Site-specific conjugation of recognition tags to trastuzumab for peptide nucleic acid-mediated radionuclide HER2 pretargeting
• Download full text (pdf) of Site-specific conjugation of recognition tags to trastuzumab for peptide nucleic acid-mediated radionuclide HER2 pretargeting

Comparative Evaluation of Two DARPin Variants: Effect of Affinity, Size, and Label on Tumor Targeting Properties

Deyev, Sergey; Vorobyeva, Anzhelika; Schulga, Alexey; Proshkina, Galina et al.

Part of Molecular Pharmaceutics, p. 995-1008, 2019

• DOI for Comparative Evaluation of Two DARPin Variants: Effect of Affinity, Size, and Label on Tumor Targeting Properties

Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours

Garousi, Javad; Lindbo, Sarah; Borin, Jesper; von Witting, Emma et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 37-48, 2019

• DOI for Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours
• Download full text (pdf) of Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours

Affibody-mediated imaging of EGFR expression in prostate cancer using radiocobalt-labeled DOTA-Z(EGFR:2377)

Mitran, Bogdan; Andersson, Ken Gosta; Lindström, Elin; Garousi, Javad et al.

Part of Oncology Reports, p. 534-542, 2019

• DOI for Affibody-mediated imaging of EGFR expression in prostate cancer using radiocobalt-labeled DOTA-Z(EGFR:2377)

Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors

Vorobyeva, Anzhelika; Bragina, Olga; Altai, Mohamed; Mitran, Bogdan et al.

Part of Contrast Media & Molecular Imaging, p. 1-11, 2018

• DOI for Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors
• Download full text (pdf) of Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors

Affibody-derived drug conjugates: Potent cytotoxic molecules for treatment of HER2 over-expressing tumors

Altai, Mohamed; Liu, Hao; Ding, Haozhong; Mitran, Bogdan et al.

Part of Journal of Controlled Release, p. 84-95, 2018

• DOI for Affibody-derived drug conjugates: Potent cytotoxic molecules for treatment of HER2 over-expressing tumors

Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs

Altai, Mohamed; Leitao, Charles Dahlsson; Rinne, Sara S.; Vorobyeva, Anzhelika et al.

Part of Cells, 2018

• DOI for Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs
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Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab

Orlova, Anna; Bass, Tarek Z.; Rinne, Sara S.; Leitao, Charles Dahlsson et al.

Part of Molecular Pharmaceutics, p. 3394-3403, 2018

• DOI for Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab

Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model

Mitran, Bogdan; Güler, Rezan; Roche, Francis P.; Lindström, Elin et al.

Part of Theranostics, p. 4462-4476, 2018

• DOI for Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model
• Download full text (pdf) of Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model

Development of an optimal imaging strategy for selection of patients for affibody-based PNA-mediated radionuclide therapy

Vorobyeva, Anzhelika; Westerlund, Kristina; Mitran, Bogdan; Altai, Mohamed et al.

Part of Scientific Reports, 2018

• DOI for Development of an optimal imaging strategy for selection of patients for affibody-based PNA-mediated radionuclide therapy
• Download full text (pdf) of Development of an optimal imaging strategy for selection of patients for affibody-based PNA-mediated radionuclide therapy

Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe

Honarvar, Hadis; Calce, Enrica; Doti, Nunzianna; Langella, Emma et al.

Part of Scientific Reports, 2018

• DOI for Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe
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Molecular design of radiocopper-labelled Affibody molecules

Tolmachev, Vladimir; Grönroos, Tove J; Yim, Cheng-Bin; Garousi, Javad et al.

Part of Scientific Reports, 2018

• DOI for Molecular design of radiocopper-labelled Affibody molecules
• Download full text (pdf) of Molecular design of radiocopper-labelled Affibody molecules

PP15 89Zr-Siderophore-Affibody conjugates for imaging EGFR expression

Summer, D; Garousi, Javad; Oroujeni, Maryam; Mitran, Bogdan et al.

Part of EJNMMI Research, 2018

• DOI for PP15 89Zr-Siderophore-Affibody conjugates for imaging EGFR expression

Influence of composition of cysteine-containing peptide-based chelators on biodistribution of ^99mTc-labeled anti-EGFR affibody molecules

Oroujeni, Maryam; Andersson, Ken G.; Steinhardt, Xenia; Altai, Mohamed et al.

Part of Amino Acids, p. 981-994, 2018

• DOI for Influence of composition of cysteine-containing peptide-based chelators on biodistribution of ^99mTc-labeled anti-EGFR affibody molecules
• Download full text (pdf) of Influence of composition of cysteine-containing peptide-based chelators on biodistribution of ^99mTc-labeled anti-EGFR affibody molecules

Preclinical Evaluation of [Ga-68]Ga-DFO-ZEGFR:2377: A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors

Oroujeni, Maryam; Garousi, Javad; Andersson, Ken G.; Lofblom, John et al.

Part of CELLS, 2018

• DOI for Preclinical Evaluation of [Ga-68]Ga-DFO-ZEGFR:2377: A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors
• Download full text (pdf) of Preclinical Evaluation of [Ga-68]Ga-DFO-ZEGFR:2377: A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors

Cyclic versus Noncyclic Chelating Scaffold for Zr-89-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression

Summer, Dominik; Garousi, Javad; Oroujeni, Maryam; Mitran, Bogdan et al.

Part of Molecular Pharmaceutics, p. 175-185, 2018

• DOI for Cyclic versus Noncyclic Chelating Scaffold for Zr-89-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression
• Download full text (pdf) of Cyclic versus Noncyclic Chelating Scaffold for Zr-89-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression

Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle

Westerlund, Kristina; Altai, Mohamed; Mitran, Bogdan; Konijnenberg, Mark et al.

Part of Journal of Nuclear Medicine, p. 1092-1098, 2018

• DOI for Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle

Selection of the most optimal ADAPT6-based probe for imaging of HER2 using PET and SPECT

Garousi, Javad; Lindbo, S.; Mitran, Bogdan; Vorobyeva, Anzhelika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

Optimized Molecular Design of ADAPT-Based HER2-Imaging Probes Labeled with ¹¹¹In and ⁶⁸Ga

Lindbo, Sarah; Garousi, Javad; Mitran, Bogdan; Vorobyeva, Anzhelika et al.

Part of Molecular Pharmaceutics, p. 2674-2683, 2018

• DOI for Optimized Molecular Design of ADAPT-Based HER2-Imaging Probes Labeled with ¹¹¹In and ⁶⁸Ga

Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Molecular Imaging of HER2 Expression in Cancer Using SPECT

Vorobyeva, Anzhelika; Bragina, O.; Altai, Mohamed; Mitran, Bogdan et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Molecular Imaging of HER2 Expression in Cancer Using SPECT

Development of a PET Imaging Approach for Selection of Patients for Affibody-Based PNA-Mediated Pretargeted Radionuclide Therapy

Vorobyeva, Anzhelika; Westerlund, K.; Mitran, Bogdan; Altai, Mohamed et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for Development of a PET Imaging Approach for Selection of Patients for Affibody-Based PNA-Mediated Pretargeted Radionuclide Therapy

Imaging contrast of HER3 expression using monomeric affibody-based imaging probe can be improved by co-injection of affibody trimer

Orlova, Anna; Rosestedt, Maria; Rinne, Sara S.; Mitran, Bogdan et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for Imaging contrast of HER3 expression using monomeric affibody-based imaging probe can be improved by co-injection of affibody trimer

Comparative evaluation of anti-EFGR affibody molecules labelled with gallium-68 and zirconium-89 using desferrioxamine B as a chelator

Oroujeni, Maryam; Garousi, Javad; Andersson, K.; Löfblom, J. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for Comparative evaluation of anti-EFGR affibody molecules labelled with gallium-68 and zirconium-89 using desferrioxamine B as a chelator

Optimization of molecular design of Ga-68-labeled affibody molecule for PET imaging of HER3 expression

Rinne, Sara S.; Mitran, Bogdan; Vorobyeva, Anzhelika; Leitao, C. Dahlsson et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for Optimization of molecular design of Ga-68-labeled affibody molecule for PET imaging of HER3 expression

Selection of optimal macrocyclic chelator for high contrast PET imaging of gastrin releasing peptide receptor using cobalt-labeled bombesin antagonist RM26

Mitran, Bogdan; Thisgaard, H.; Rinne, Sara S.; Rosenström, Ulrika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

GRPR-targeted radiotherapy using the Lu-177-labeled GRPR-antagonist DOTAGA-PEG(2)-RM26

Mitran, Bogdan; Rinne, Sara S.; Azamy, F.; Vorobyeva, Anzhelika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

Same-day imaging using small proteins: Clinical experience and translational prospects in oncology.

Krasniqi, Ahmet; D'Huyvetter, Matthias; Devoogdt, Nick; Frejd, Fredrik Y. et al.

Part of Journal of Nuclear Medicine, p. 885-891, 2018

• DOI for Same-day imaging using small proteins: Clinical experience and translational prospects in oncology.

Radionuclide tumor targeting using ADAPT scaffold proteins: aspects of label positioning and residualizing properties of the label

Lindbo, Sarah; Garousi, Javad; Mitran, Bogdan; Buijs, Jos et al.

Part of Journal of Nuclear Medicine, p. 93-99, 2018

• DOI for Radionuclide tumor targeting using ADAPT scaffold proteins: aspects of label positioning and residualizing properties of the label

In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin- binding therapeutic affibody construct

Bass, Tarek Z.; Rosestedt, Maria; Mitran, Bogdan; Frejd, Fredrik Y. et al.

Part of Scientific Reports, 2017

• DOI for In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin- binding therapeutic affibody construct
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The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule

Garousi, Javad; Andersson, Ken G.; Dam, Johan H.; Olsen, Birgitte B. et al.

Part of Scientific Reports, 2017

• DOI for The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule
• Download full text (pdf) of The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule

Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m

Garousi, Javad; Lindbo, Sarah; Mitran, Bogdan; Buijs, Jos et al.

Part of Scientific Reports, 2017

• DOI for Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m
• Download full text (pdf) of Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m

Evaluation of radiocobalt-labelled affibody molecule for imaging of human epidermal growth factor receptor 3 expression

Rosestedt, Maria; Andersson, Ken G; Mitran, Bogdan; Rinne, Sara S. et al.

Part of International Journal of Oncology, p. 1765-1774, 2017

• DOI for Evaluation of radiocobalt-labelled affibody molecule for imaging of human epidermal growth factor receptor 3 expression
• Download full text (pdf) of Evaluation of radiocobalt-labelled affibody molecule for imaging of human epidermal growth factor receptor 3 expression

High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26

Mitran, Bogdan; Thisgaard, Helge; Rosenström, Ulrika; Dam, Johan Hygum et al.

Part of Contrast Media & Molecular Imaging, 2017

• DOI for High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
• Download full text (pdf) of High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26

Novel high affinity affibody for radionuclide imaging of VEGFR2 in glioma vasculature: proof-of-principle in murine model

Mitran, Bogdan; Guler, R.; Roche, Francis P.; Lindström, Elin et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

Radiocobalt-labeled anti-HER1 affibody molecule DOTA-Z(EGFR:2377) for imaging of low HER1 expression in prostate cancer pre-clinical model

Mitran, Bogdan; Garousi, Javad; Rosestedt, Maria; Lindström, Elin et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

GRPR-Targeted Radiotherapy: Influence of Chelator on Labeling and Biodistribution of Four Lu-177-Labeled Analogues of the GRPR-Antagonist PEG2-RM26

Orlova, Anna; Mitran, Bogdan; Maina, T.; Nock, B. A. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

Influence of composition of cysteine-containing peptide based chelators on biodistribution of Tc-99m-labelled anti-EGFR affibody molecules

Oroujeni, Maryam; Anderson, K. G.; Garousi, Javad; Altai, Mohamed et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

Optimization of affibody molecule for imaging of HER3 expression: negatively charged metal-chelator complex increases imaging contrast

Rinne, Sara S.; Mitran, Bogdan; Leitao, C. Dahlsson; Ståhl, S. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

Optimal molecular design of radiocopper-labelled affibody molecules

Tolmachev, Vladimir; Yim, C.; Garousi, Javad; Yue, Y. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

Comparative Evaluation of Anti-HER2 Affibody Molecules Labeled with Cu-64 Using NOTA and NODAGA

Tolmachev, Vladimir; Yim, Cheng-Bin; Rajander, Johan; Perols, Anna et al.

Part of Contrast Media & Molecular Imaging, p. 1-12, 2017

• DOI for Comparative Evaluation of Anti-HER2 Affibody Molecules Labeled with Cu-64 Using NOTA and NODAGA
• Download full text (pdf) of Comparative Evaluation of Anti-HER2 Affibody Molecules Labeled with Cu-64 Using NOTA and NODAGA

Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO

Stevens, Marc; Chow, Shiao; Estrada, Sergio; Eriksson, Jonas et al.

Part of ChemistryOpen, p. 566-573, 2016

• DOI for Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO
• Download full text (pdf) of Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO

Feasibility of Affibody Molecule-Based PNA-Mediated Radionuclide Pretargeting of Malignant Tumors

Honarvar, Hadis; Westerlund, Kristina; Altai, Mohamed; Sandström, Mattias et al.

Part of Theranostics, p. 93-103, 2016

• DOI for Feasibility of Affibody Molecule-Based PNA-Mediated Radionuclide Pretargeting of Malignant Tumors
• Download full text (pdf) of Feasibility of Affibody Molecule-Based PNA-Mediated Radionuclide Pretargeting of Malignant Tumors

Measuring HER2-Receptor Expression In Metastatic Breast Cancer Using [(68)Ga]ABY-025 Affibody PET/CT

Sörensen, Jens; Velikyan, Irina; Sandberg, Dan; Wennborg, Anders et al.

Part of Theranostics, p. 262-271, 2016

• DOI for Measuring HER2-Receptor Expression In Metastatic Breast Cancer Using [(68)Ga]ABY-025 Affibody PET/CT
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Synthesis of ¹¹C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [¹¹C]CO

Stevens, Marc; Chow, Chow; Estrada, Sergio; Eriksson, Jonas et al.

Part of ChemistryOpen, p. 566-573, 2016

• DOI for Synthesis of ¹¹C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [¹¹C]CO
• Download full text (pdf) of Synthesis of ¹¹C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [¹¹C]CO

Comparative evaluation of Affibody molecules for radionuclide imaging of in vivo expression of carbonic anhydrase IX

Garousi, Javad; Honarvar, Hadis; Andersson, Ken G.; Mitran, Bogdan et al.

Part of Molecular Pharmaceutics, p. 3676-3687, 2016

• DOI for Comparative evaluation of Affibody molecules for radionuclide imaging of in vivo expression of carbonic anhydrase IX

Increasing the Net Negative Charge by Replacement of DOTA Chelator with DOTAGA Improves the Biodistribution of Radiolabeled Second-Generation Synthetic Affibody Molecules

Westerlund, Kristina; Honarvar, Hadis; Norrström, Emily; Strand, Joanna et al.

Part of Molecular Pharmaceutics, p. 1668-1678, 2016

• DOI for Increasing the Net Negative Charge by Replacement of DOTA Chelator with DOTAGA Improves the Biodistribution of Radiolabeled Second-Generation Synthetic Affibody Molecules

Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26.

Mitran, Bogdan; Varasteh, Zohreh; Selvaraju, Ram Kumar; Lindeberg, Gunnar et al.

Part of International journal of oncology, p. 2124-2134, 2016

• DOI for Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26.

Feasibility of imaging of epidermal growth factor receptor expression with ZEGFR: 2377 affibody molecule labeled with 99mTc using a peptide-based cysteine-containing chelator

Andersson, Ken G.; Oroujeni, Maryam; Garousi, Javad; Mitran, Bogdan et al.

Part of International journal of oncology, p. 2285-2293, 2016

• DOI for Feasibility of imaging of epidermal growth factor receptor expression with ZEGFR: 2377 affibody molecule labeled with 99mTc using a peptide-based cysteine-containing chelator
• Download full text (pdf) of Feasibility of imaging of epidermal growth factor receptor expression with ZEGFR: 2377 affibody molecule labeled with 99mTc using a peptide-based cysteine-containing chelator

Influence of molecular design on biodistribution and targeting properties of an Affibody-fused HER2-recognising anticancer toxin

Altai, Mohamed; Liu, Hao; Orlova, Anna; Tolmachev, Vladimir et al.

Part of International Journal of Oncology, p. 1185-1194, 2016

• DOI for Influence of molecular design on biodistribution and targeting properties of an Affibody-fused HER2-recognising anticancer toxin

Feasibility of in vivo imaging of VEGFR2 expression using high affinity antagonistic biparatopic affibody construct Z(VEGFR2)-Bp(2)

Mitran, Bogdan; Guler, R.; Lindström, Eva; Fleetwood, F. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

Influence of Histidine-Containing Tags on the Biodistribution of ADAPT Scaffold Proteins.

Lindbo, Sarah; Garousi, Javad; Åstrand, Mikael; Honarvar, Hadis et al.

Part of Bioconjugate chemistry, p. 716-726, 2016

• DOI for Influence of Histidine-Containing Tags on the Biodistribution of ADAPT Scaffold Proteins.

Feasibility of affibody-based bioorthogonal chemistry-mediated radionuclide pretargeting

Altai, Mohamed; Perols, Anna; Tsourma, Maria; Mitran, Bogdan et al.

Part of Journal of Nuclear Medicine, p. 431-436, 2016

• DOI for Feasibility of affibody-based bioorthogonal chemistry-mediated radionuclide pretargeting

Improving of molecular design of a novel Affibody-fused HER2-recognising anticancer toxin using radionuclide-based techniques

Altai, Mohamed; Liu, H.; Orlova, Anna; Tolmachev, Vladimir et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

Development and Evaluation of Radiocobalt-labelled Affibody Molecule for Next Day PET Imaging of HER3 Expression

Rosestedt, Maria; Mitran, Bogdan; Andersson, K. G.; Löfblom, J. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

Evaluation of Affibody Molecules for Radionuclide Imaging of Carbonic Abhydrase IX Expression In Vivo

Garousi, Javad; Honarvar, Hadis; Andersson, K.; Mitran, Bogdan et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

Imaging of EGFR Expression Using 99mTC-Labelled ZEGFR:2377 Affibody Molecule

Oroujeni, Maryam; Andersson, K.; Garousi, Javad; Mitran, Bogdan et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

Influence of the N-Terminal Composition on Targeting Properties of Radiometal-Labeled Anti-HER2 Scaffold Protein ADAPT6

Garousi, Javad; Lindbo, Sarah; Honarvar, Hadis; Velletta, Justin et al.

Part of Bioconjugate chemistry, p. 2678-2688, 2016

• DOI for Influence of the N-Terminal Composition on Targeting Properties of Radiometal-Labeled Anti-HER2 Scaffold Protein ADAPT6

Influence of the N-terminal amino acid sequence on imaging properties of In-111-labeled anti-HER2 scaffold protein ADAPT6

Garousi, Javad; Lindbo, S.; Honarvar, Hadis; Velletta, J. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

In vivo evaluation of pharmacokinetics, tumors targeting and therapeutic efficacy of a novel format of HER3-targeting affibody molecule with prolonged blood circulation

Orlova, Anna; Rosestedt, Maria; Mitran, Bogdan; Bass, T. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

Comparative evaluation of Lu-177-HP2 and In-111-HP2, secondary agents for affibody-based PNA-mediated radionuclide pretargeting

Altai, Mohamed; Westerlund, K.; Velletta, J.; Honarvar, Hadis et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule Ga-68-ABY-025 in Breast Cancer Patients

Sandström, Mattias; Lindskog, Karolina; Velikyan, Irma; Wennborg, Anders et al.

Part of Journal of Nuclear Medicine, p. 867-871, 2016

• DOI for Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule Ga-68-ABY-025 in Breast Cancer Patients

PET imaging of epidermal growth factor receptor expression in tumours using 89Zr-labelled ZEGFR: 2377 affibody molecules.

Garousi, Javad; Andersson, Ken G; Mitran, Bogdan; Pichl, Marie-Louise et al.

Part of International journal of oncology, p. 1325-1332, 2016

• DOI for PET imaging of epidermal growth factor receptor expression in tumours using 89Zr-labelled ZEGFR: 2377 affibody molecules.
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ADAPT, a novel scaffold protein-based probe for radionuclide imaging of molecular targets that are expressed in disseminated cancers

Garousi, Javad; Lindbo, Sarah; Nilvebrant, Johan; Åstrand, Mikael et al.

Part of Cancer Research, p. 4364-4371, 2015

• DOI for ADAPT, a novel scaffold protein-based probe for radionuclide imaging of molecular targets that are expressed in disseminated cancers

Affibody-mediated PET imaging of HER3 expression in malignant tumours

Rosestedt, Maria; Andersson, Ken G.; Mitran, Bogdan; Tolmachev, Vladimir et al.

Part of Scientific Reports, 2015

• DOI for Affibody-mediated PET imaging of HER3 expression in malignant tumours
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Influence of chelators on targeting properties of In-111 and Ga-68 labeled GRPR antagonist

Orlova, Anna; Varasteh, Zohreh; Mitran, Bogdan; Rosestedt, Maria et al.

Part of Journal of labelled compounds & radiopharmaceuticals, 2015

The use of radiocobalt as a label improves PET imaging of EGFR using DOTA-conjugated affibody molecules

Garousi, Javad; Anderson, K.; Dam, J. H.; Olsen, B. B. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015

Development of radiocobalt-labeled GRPR antagonist NOTA-PEG2-RM26.

Mitran, Bogdan; Varasteh, Zohreh; Rosenström, Ulrika; Tolmachev, Vladimir et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015

Comparing the measured affinity of 111In-labeled ligands for cellular receptors by monitoring gamma, beta, or x-ray radiation with three different LigandTracer® devices

Orlova, Anna; varasteh, Zohreh

Part of Journal of Radioanalytical and Nuclear Chemistry, p. 823-828, 2015

Comparative evaluation of 111In-labeled NOTA‑conjugated affibody molecules for visualization of HER3 expression in malignant tumors

Andersson, Ken G.; Rosestedt, Maria; Varasteh, Zohreh; Malm, Magdalena et al.

Part of Oncology Reports, p. 1042-1048, 2015

• DOI for Comparative evaluation of 111In-labeled NOTA‑conjugated affibody molecules for visualization of HER3 expression in malignant tumors
• Download full text (pdf) of Comparative evaluation of 111In-labeled NOTA‑conjugated affibody molecules for visualization of HER3 expression in malignant tumors

Evaluation of (99m)Tc-Z IGF1R:4551-GGGC affibody molecule, a new probe for imaging of insulin-like growth factor type 1 receptor expression

Mitran, Bogdan; Altai, Mohamed; Hofström, Camilla; Honarvar, Hadis et al.

Part of Amino Acids, p. 303-15, 2015

• DOI for Evaluation of (99m)Tc-Z IGF1R:4551-GGGC affibody molecule, a new probe for imaging of insulin-like growth factor type 1 receptor expression
• Download full text (pdf) of Evaluation of (99m)Tc-Z IGF1R:4551-GGGC affibody molecule, a new probe for imaging of insulin-like growth factor type 1 receptor expression

The effect of macrocyclic chelators on the targeting properties of the ⁶⁸Ga-labeled gastrin releasing peptide receptor antagonist PEG₂-RM26

Varasteh, Zohreh; Mitran, Bogdan; Rosenström, Ulrika; Velikyan, Irina et al.

Part of Nuclear Medicine and Biology, p. 446-454, 2015

• DOI for The effect of macrocyclic chelators on the targeting properties of the ⁶⁸Ga-labeled gastrin releasing peptide receptor antagonist PEG₂-RM26

Comparing the measured affinity of (111) In-labeled ligands for cellular receptors by monitoring gamma, beta, or X-ray radiation with three different LigandTracer (R) devices

Varasteh, Zohreh; Orlova, Anna

Part of Journal of Radioanalytical and Nuclear Chemistry, p. 823-828, 2015

• DOI for Comparing the measured affinity of (111) In-labeled ligands for cellular receptors by monitoring gamma, beta, or X-ray radiation with three different LigandTracer (R) devices

Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity

Strand, Joanna; Nordeman, Patrik; Honarvar, Hadis; Altai, Mohamed et al.

Part of ChemistryOpen, p. 174-182, 2015

• DOI for Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity
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Imaging of HER2 may improve the outcome of external irradiation therapy for prostate cancer patients

Andersson, Jennie; Rosestedt, Maria; Orlova, Anna

Part of Oncology Letters, p. 950-954, 2015

• DOI for Imaging of HER2 may improve the outcome of external irradiation therapy for prostate cancer patients

Affibody-based bioorthogonal chemistry-mediated radionuclide pretargeting: proof-of-principle

Altai, Mohamed; Tsourma, M.; Mitran, Bogdan; Honarvar, Hadis et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015

Feasibility of Affibody molecule-based PNA-mediated pretargeting

Honarvar, Hadis; Westerlund, K.; Altai, Mohamed; Sandstrom, Mattias et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015

Influence of Histidine-Containing Tags on Biodistribution of Radiolabelled ADAPT-Based Imaging Probes

Lindbo, S.; Garousi, Javad; Astrand, M.; Honarvar, Hadis et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015

Good manufacturing practice compliant production of a Ga-68-labelled Affibody agent for breast cancer imaging: first-in-human

Velikyan, Irina; Wennborg, Anders; Feldwisch, Joachim; Orlova, Anna et al.

Part of Journal of labelled compounds & radiopharmaceuticals, 2015

Position for Site-Specific Attachment of a DOTA Chelator to Synthetic Affibody Molecules Has a Different Influence on the Targeting Properties of 68Ga- Compared to 111In-Labeled Conjugates.

Honarvar, Hadis; Strand, Joanna; Perols, Anna; Orlova, Anna et al.

Part of Molecular Imaging, p. 1-12, 2014

• DOI for Position for Site-Specific Attachment of a DOTA Chelator to Synthetic Affibody Molecules Has a Different Influence on the Targeting Properties of 68Ga- Compared to 111In-Labeled Conjugates.

The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin

Varasteh, Zohreh; Rosenström, Ulrika; Velikyan, Irina; Mitran, Bogdan et al.

Part of Molecules, p. 10455-10472, 2014

• DOI for The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin
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Development of ADAPT6 as a new scaffold protein for radionuclide molecular imaging

Garousi, Javad; Lindbo, S.; Orlova, Anna; Astrand, M. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

Histidine-Rich Glycoprotein Uptake and Turnover Is Mediated by Mononuclear Phagocytes.

Tugues, Sònia; Roche, Francis; Noguer, Oriol; Orlova, Anna et al.

Part of PLOS ONE, 2014

• DOI for Histidine-Rich Glycoprotein Uptake and Turnover Is Mediated by Mononuclear Phagocytes.
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GMP compliant preparation of a (68)Gallium-labeled Affibody analogue for breast cancer patient examination: first-in-man

Velikyan, Irina; Wennborg, A.; Feldwisch, J.; Orlova, Anna et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

111In-labeled NOTA-conjugated Affibody molecules for visualization of HER3 expression in malignant tumors

Andersson, K. G.; Varasteh, Zohreh; Rosestedt, Maria; Malm, M. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

In Vitro Therapy Modeling of HER2 Targeting Therapy in Disseminated Prostate Cancer

Andersson, Jennie; Rosestedt, Maria; Asplund, Veronika; Yavari, Nazila et al.

Part of International Journal of Oncology, p. 2153-2158, 2014

• DOI for In Vitro Therapy Modeling of HER2 Targeting Therapy in Disseminated Prostate Cancer
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Development of a I-124-labeled version of the anti-PSMA monoclonal antibody capromab for immunoPET staging of prostate cancer: Aspects of labeling chemistry and biodistribution

Tolmachev, Vladimir; Malmberg, Jennie; Estrada, Sergio; Eriksson, Olof et al.

Part of International Journal of Oncology, p. 1998-2008, 2014

• DOI for Development of a I-124-labeled version of the anti-PSMA monoclonal antibody capromab for immunoPET staging of prostate cancer: Aspects of labeling chemistry and biodistribution
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Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer

Sandin, Linda; Orlova, Anna; Gustafsson, Erika; Ellmark, Peter et al.

Part of Cancer Immunology Research, p. 80-90, 2014

• DOI for Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer
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Imaging of HER3-expressing xenografts in mice using a (99m)Tc(CO) 3-HEHEHE-Z HER3 08699 affibody molecule

Orlova, Anna; Malm, Magdalena; Rosestedt, Maria; Varasteh, Zohreh et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 1450-1459, 2014

• DOI for Imaging of HER3-expressing xenografts in mice using a (99m)Tc(CO) 3-HEHEHE-Z HER3 08699 affibody molecule
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Incorporation of a Triglutamyl Spacer Improves the Biodistribution of Synthetic Affibody Molecules Radiofluorinated at the N-Terminus via Oxime Formation with (18)F-4-Fluorobenzaldehyde

Rosik, Daniel; Thibblin, Alf; Antoni, Gunnar; Honarvar, Hadis et al.

Part of Bioconjugate chemistry, p. 82-92, 2014

• DOI for Incorporation of a Triglutamyl Spacer Improves the Biodistribution of Synthetic Affibody Molecules Radiofluorinated at the N-Terminus via Oxime Formation with (18)F-4-Fluorobenzaldehyde
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¹⁸⁸Re-Z_HER2:V2, a promising affibody-based targeting agent against HER2-expressing tumors: preclinical assessment

Altai, Mohamed; Wållberg, Helena; Honarvar, Hadis; Strand, Joanna et al.

Part of Journal of Nuclear Medicine, p. 1842-1848, 2014

• DOI for ¹⁸⁸Re-Z_HER2:V2, a promising affibody-based targeting agent against HER2-expressing tumors: preclinical assessment
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Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Hosseinimehr, Seyed Jalal et al.

Part of Journal of Nuclear Medicine, p. 294-300, 2014

• DOI for Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591
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Gallium-68-Labeled Affibody Molecule for PET Imaging of PDGFRβ Expression in Vivo

Strand, Joanna; Varasteh, Zohreh; Eriksson, Olof; Abrahmsen, Lars et al.

Part of Molecular Pharmaceutics, p. 3957-3964, 2014

• DOI for Gallium-68-Labeled Affibody Molecule for PET Imaging of PDGFRβ Expression in Vivo

Selection of an optimal cysteine-containing peptide-based chelator for labeling of affibody molecules with ¹⁸⁸Re

Altai, Mohamed; Honarvar, Hadis; Wållberg, Helena; Strand, Joanna et al.

Part of European Journal of Medicinal Chemistry, p. 519-528, 2014

• DOI for Selection of an optimal cysteine-containing peptide-based chelator for labeling of affibody molecules with ¹⁸⁸Re
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Radiolabeled Probes Targeting Tyrosine-Kinase Receptors For Personalized Medicine

Altai, Mohamed; Orlova, Anna; Tolmachev, Vladimir

Part of Current pharmaceutical design, p. 2275-2292, 2014

• DOI for Radiolabeled Probes Targeting Tyrosine-Kinase Receptors For Personalized Medicine

PET Imaging of HER3-Expression in Tumours Using a 68Ga-Labeled Affibody Molecule

Rosestedt, Maria; Andersson, K.; Lofblom, J.; Mitran, Bogdan et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

Influence of chelators on biodistribution and targeting properties of GRPR antagonist

Mitran, Bogdan; Varasteh, Zohreh; Rosestedt, Maria; Velikyan, Irina et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

Evaluation of 99mTc-ZIGF1R:4551-GGGC Affibody Molecule, a New Construct for Imaging the Insulin-like Growth Factor Type 1 Receptor Expression

Mitran, Bogdan; Altai, M.; Hofstrom, C.; Honarvar, Hadis et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

Gallium-68-labeled affibody molecule for PET imaging of PDGFR beta expression in vivo

Strand, Joanna; Varasteh, Zohreh; Eriksson, Olof; Abrahmsen, L. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

[^99mTc(CO)₃]⁺-(HE)₃-Z_IGF1R:4551, a new Affibody conjugate for visualization of insulin-like growth factor-1 receptor expression in malignant tumours

Orlova, Anna; Hofström, Camilla; Strand, Joanna; Varasteh, Zohreh et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 439-449, 2013

• DOI for [^99mTc(CO)₃]⁺-(HE)₃-Z_IGF1R:4551, a new Affibody conjugate for visualization of insulin-like growth factor-1 receptor expression in malignant tumours
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Influence of Macrocyclic Chelators on the Targeting Properties of ⁶⁸Ga-Labeled Synthetic Affibody Molecules: Comparison with ¹¹¹In-Labeled Counterparts

Strand, Joanna; Honarvar, Hadis; Perols, Anna; Orlova, Anna et al.

Part of PLOS ONE, 2013

• DOI for Influence of Macrocyclic Chelators on the Targeting Properties of ⁶⁸Ga-Labeled Synthetic Affibody Molecules: Comparison with ¹¹¹In-Labeled Counterparts
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Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification

Malm, Magdalena; Kronqvist, Nina; Lindberg, Hanna; Gudmundsdotter, Lindvi et al.

Part of PLOS ONE, 2013

• DOI for Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification
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In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging

Varasteh, Zohreh; Åberg, Ola; Velikyan, Irina; Lindeberg, Gunnar et al.

Part of PLOS ONE, 2013

• DOI for In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging
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Detecting ligand interactions with G protein-coupled receptors in real-time on living cells

Xu, Bo; Varasteh, Zohreh; Orlova, Anna; Andersson, Karl et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 820-824, 2013

• DOI for Detecting ligand interactions with G protein-coupled receptors in real-time on living cells
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Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein

Orlova, Anna; Jonsson, Andreas; Rosik, Daniel; Lundqvist, Hans et al.

Part of Journal of Nuclear Medicine, p. 961-968, 2013

• DOI for Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein
• Download full text (pdf) of Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein

HAHAHA, HEHEHE, HIHIHI, or HKHKHK: Influence of Position and Composition of Histidine Containing Tags on Biodistribution of [^99mTc(CO)₃]⁺-Labeled Affibody Molecules

Hofström, Camilla; Altai, Mohamed; Honarvar, Hadis; Strand, Joanna et al.

Part of Journal of Medicinal Chemistry, p. 4966-4974, 2013

• DOI for HAHAHA, HEHEHE, HIHIHI, or HKHKHK: Influence of Position and Composition of Histidine Containing Tags on Biodistribution of [^99mTc(CO)₃]⁺-Labeled Affibody Molecules
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Influence of Nuclides and Chelators on Imaging Using Affibody Molecules: Comparative Evaluation of Recombinant Affibody Molecules Site-Specifically Labeled with ⁶⁸Ga and ¹¹¹In via Maleimido Derivatives of DOTA and NODAGA

Altai, Mohamed; Strand, Joanna; Rosik, Daniel; Selvaraju, Ram Kumar et al.

Part of Bioconjugate chemistry, p. 1102-1109, 2013

• DOI for Influence of Nuclides and Chelators on Imaging Using Affibody Molecules: Comparative Evaluation of Recombinant Affibody Molecules Site-Specifically Labeled with ⁶⁸Ga and ¹¹¹In via Maleimido Derivatives of DOTA and NODAGA
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HAHAHA-, HIHIHI-. HKHKHK. HHHHHH- and HEHEHE- tags: Influence of position and composition of histidine-containing tags on biodistribution of [99mTc(CO) 3]+- labeled affibody molecules

Tolmachev, Vladimir; Hofstrom, C.; Altai, Mohamed; Honarvar, Hadis et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013

Selection of an optimal cysteine-containing peptide-based chelator for labeling of Affibody molecules with 188-Re

Altai, Mohamed; Honarvar, Hadis; Wållberg, Helena; Strand, Joanna et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013

• DOI for Selection of an optimal cysteine-containing peptide-based chelator for labeling of Affibody molecules with 188-Re

Increase of HER2 expression in prostate cancer cell lines as reaction on external irradiation

Malmberg, Jennie; Rosestedt, Maria; Orlova, Anna

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013

Feasibility of radionuclide imaging of HER3-expressing tumours using technetium-99m labeled affibody molecules

Orlova, Anna; Malm, M.; Lindberg, H.; Varasteh, Zohreh et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013

Influence of macrocyclic chelators on biodistribution and targeting properties of 68Ga-labeled synthetic Affibody molecules. Comparison with 111In-labeled counterparts

Strand, Joanna; Honarvar, Hadis; Perols, A.; Orlova, Anna et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013

Imaging of PDGFRbeta expression in vivo using Affibody molecule In-111-DOTA-Z09591

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Hosseinimehr, S. Jalal et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013

Evaluation of backbone-cyclized HER2-binding 2-helix Affibody molecule for In Vivo molecular imaging

Honarvar, Hadis; Jokilaakso, Nima; Andersson, Karl; Malmberg, Jennie et al.

Part of Nuclear Medicine and Biology, p. 378-386, 2013

• DOI for Evaluation of backbone-cyclized HER2-binding 2-helix Affibody molecule for In Vivo molecular imaging
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Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging

Varasteh, Zohreh; Velikyan, Irina; Lindeberg, Gunnar; Sörensen, Jens et al.

Part of Bioconjugate chemistry, p. 1144-1153, 2013

• DOI for Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging
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(AlF)-F-18-labelling of NOTA-P2-RM26 and its evaluation as a PET ligand for GRPR/BB2

Åberg, Ola; Varasteh, Zohreh; Lindeberg, Gunnar; Larhed, Mats et al.

Part of Journal of labelled compounds & radiopharmaceuticals, 2013

In Vivo and In Vitro Studies on Renal Uptake of Radiolabeled Affibody Molecules for Imaging of HER2 Expression in Tumors

Altai, Mohamed; Varasteh, Zohreh; Andersson, Karl; Eek, Annemarie et al.

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 187-195, 2013

• DOI for In Vivo and In Vitro Studies on Renal Uptake of Radiolabeled Affibody Molecules for Imaging of HER2 Expression in Tumors
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Feasibility of radionuclide imaging of HER3-expressing tumors using affibody molecules

Orlova, Anna; Malm, Magdalena; Lindberg, Hanna; Varasteh, Zohreh et al.

Part of Journal of labelled compounds & radiopharmaceuticals, 2013

In vivo imaging of PDGFR beta expression using In-111-DOTA-Z09591 Affibody molecule

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Eriksson, Olof et al.

Part of Journal of labelled compounds & radiopharmaceuticals, 2013

GRPR antagonist NOTA-P2-RM26 labeled with fluorine-18: radiochemistry, in vitro and in vivo evaluation

Varasteh, Zohreh; Åberg, Ola; Lindberg, G.; Antoni, Gunnar et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013

Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts.

Malmberg, Jennie; Perols, Anna; Varasteh, Zohreh; Altai, Mohamed et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 481-492, 2012

• DOI for Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts.

Preclinical evaluation of anti-HER2 Affibody molecules site-specifically labeled with ¹¹¹In using a maleimido derivative of NODAGA

Altai, Mohamed; Perols, Anna; Eriksson Karlström, Amelie; Sandström, Mattias et al.

Part of Nuclear Medicine and Biology, p. 518-529, 2012

• DOI for Preclinical evaluation of anti-HER2 Affibody molecules site-specifically labeled with ¹¹¹In using a maleimido derivative of NODAGA

Direct comparison of In-111-labelled two-helix and three-helix Affibody molecules for in vivo molecular imaging

Rosik, Daniel; Orlova, Anna; Malmberg, Jennie; Altai, Mohamed et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 693-702, 2012

• DOI for Direct comparison of In-111-labelled two-helix and three-helix Affibody molecules for in vivo molecular imaging

Protein interactions with HER-family receptors can have different characteristics depending on the hosting cell line

Barta, Pavel; Malmberg, Jennie; Melicharova, Ludmila; Strandgård, John et al.

Part of International Journal of Oncology, p. 1677-1682, 2012

• DOI for Protein interactions with HER-family receptors can have different characteristics depending on the hosting cell line

Liver uptake of radiolabeled targeting proteins and peptides: considerations for targeting peptide conjugate design

Hosseinimehr, Seyed Jalal; Tolmachev, Vladimir; Orlova, Anna

Part of Drug Discovery Today, p. 1224-1232, 2012

• DOI for Liver uptake of radiolabeled targeting proteins and peptides: considerations for targeting peptide conjugate design

Imaging of Insulinlike Growth Factor Type 1 Receptor in Prostate Cancer Xenografts Using the Affibody Molecule ¹¹¹In-DOTA-Z_IGF1R:4551

Tolmachev, Vladimir; Malmberg, Jennie; Hofström, Camilla; Abrahmsén, Lars et al.

Part of Journal of Nuclear Medicine, p. 90-97, 2012

• DOI for Imaging of Insulinlike Growth Factor Type 1 Receptor in Prostate Cancer Xenografts Using the Affibody Molecule ¹¹¹In-DOTA-Z_IGF1R:4551

99mTc(CO)3-HEHEHE-ZIGF1R:4551 affibody molecule, a poteintial imaging agent for visualization of insulin-like growth factor-1 receptor in malignant tumors

Tolmachev, Vladimir; Hofstrom, C.; Strand, J.; Varasteh, Zohreh et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012

Comparative evaluation of anti-HER2 affibody molecules labeled with 68Ga and 111In using maleimido derivatives of DOTA and NODAGA

Altai, Mohamed; Strand, Joanna; Rosik, D.; Selvaraju, Ram Kumar et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012

Influence of DOTA chelator position on biodistribution and targeting properties of 111 In-labelled anti-HER2 affibody molecules

Honarvar, Hadis; Perols, A.; Strand, Joanna; Selvaraju, Ram Kumar et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012

Development of 124I-labelled anti-PSMA monoclonal antibody capromab for immunoPET staging of prostate cancer

Malmberg, Jennie; Selvaraju, Ram Kumar; Tolmachev, Vladimir; Orlova, Anna

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012

Site-specific radioiodination of HER2-targeting affibody molecules using iodophenetylmaleimide decreases renal uptake of radioactivity

Strand, Joanna; Nordeman, Patrik; Honarvar, Hadis; Altai, Mohamed et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012

Synthesis and characterization of a high affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging

Varasteh, Zohreh; Velikyan, Irina; Lindeberg, Gunnar; Sörensen, Jens et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012

Influence of DOTA Chelator Position on Biodistribution and Targeting Properties of In-111-Labeled Synthetic Anti-HER2 Affibody Molecules

Perols, Anna; Honarvar, Hadis; Strand, Joanna; Selvaraju, Ramkumar et al.

Part of Bioconjugate chemistry, p. 1661-1670, 2012

• DOI for Influence of DOTA Chelator Position on Biodistribution and Targeting Properties of In-111-Labeled Synthetic Anti-HER2 Affibody Molecules

Tumor Targeting Using Affibody Molecules: Interplay of Affinity, Target Expression Level, and Binding Site Composition

Tolmachev, Vladimir; Tran, Thuy A; Rosik, Daniel; Sjöberg, Anna et al.

Part of Journal of Nuclear Medicine, p. 953-960, 2012

• DOI for Tumor Targeting Using Affibody Molecules: Interplay of Affinity, Target Expression Level, and Binding Site Composition

Evaluation of a HER2-targeting affibody molecule combining an N-terminal HEHEHE-tag with a GGGC chelator for ^99mTc-labelling at the C terminus

Lindberg, Hanna; Hofström, Camilla; Altai, Mohamed; Honorvar, Hadis et al.

Part of Tumor Biology, p. 641-651, 2012

• DOI for Evaluation of a HER2-targeting affibody molecule combining an N-terminal HEHEHE-tag with a GGGC chelator for ^99mTc-labelling at the C terminus

Order of amino acids in C-terminal cysteine-containing peptide-based chelators influences cellular processing and biodistribution of (99m)Tc-labeled recombinant Affibody molecules

Altai, Mohamed; Wållberg, Helena; Orlova, Anna; Rosestedt, Maria et al.

Part of Amino Acids, p. 1975-1985, 2012

• DOI for Order of amino acids in C-terminal cysteine-containing peptide-based chelators influences cellular processing and biodistribution of (99m)Tc-labeled recombinant Affibody molecules

Use of a HEHEHE Purification Tag Instead of a Hexahistidine Tag Improves Biodistribution of Affibody Molecules Site-Specifically Labeled with Tc-99m, In-111 and I-125

Hofström, Camilla; Orlova, Anna; Altai, Mohamed; Wångsell, Fredrik et al.

Part of Journal of Medicinal Chemistry, p. 3817-3826, 2011

• DOI for Use of a HEHEHE Purification Tag Instead of a Hexahistidine Tag Improves Biodistribution of Affibody Molecules Site-Specifically Labeled with Tc-99m, In-111 and I-125

Optimal specific radioactivity of anti-HER2 Affibody molecules enables discrimination between xenografts with high and low HER2 expression levels

Tolmachev, Vladimir; Wållberg, Helena; Sandström, Mattias; Hansson, Monika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 531-539, 2011

• DOI for Optimal specific radioactivity of anti-HER2 Affibody molecules enables discrimination between xenografts with high and low HER2 expression levels

Molecular Design and Optimization of 99mTc-Labeled Recombinant Affibody Molecules Improves Their Biodistribution and Imaging Properties

Wållberg, Helena; Orlova, Anna; Altai, Mohammed; Hosseinimehr, Seyed Jalal et al.

Part of Journal of Nuclear Medicine, p. 461-469, 2011

• DOI for Molecular Design and Optimization of 99mTc-Labeled Recombinant Affibody Molecules Improves Their Biodistribution and Imaging Properties

Evaluation of a Maleimido Derivative of NOTA for Site-Specific Labeling of Affibody Molecules

Tolmachev, Vladimir; Altai, Mohamed; Sandström, Mattias; Perols, Anna et al.

Part of Bioconjugate chemistry, p. 894-902, 2011

• DOI for Evaluation of a Maleimido Derivative of NOTA for Site-Specific Labeling of Affibody Molecules

Engineering of C-terminal cysteine-containing peptide-based chelators improves biodistribution of HER2-targeting ^99mTc-labeled Affibody molecules

Wållberg, H; Orlova, Anna; Altai, Mohammed; Hosseinimehr, Seyed Jalal et al.

Part of Journal of Nuclear Medicine, p. 461-469, 2011

• DOI for Engineering of C-terminal cysteine-containing peptide-based chelators improves biodistribution of HER2-targeting ^99mTc-labeled Affibody molecules

Influence of an aliphatic linker between DOTA and synthetic Z(HER2:342) Affibody molecule on targeting properties of the (111)In-labeled conjugate

Tolmachev, Vladimir; Feldwisch, Joachim; Lindborg, Malin; Baastrup, Barbro et al.

Part of Nuclear Medicine and Biology, p. 697-706, 2011

• DOI for Influence of an aliphatic linker between DOTA and synthetic Z(HER2:342) Affibody molecule on targeting properties of the (111)In-labeled conjugate

Imaging agents for in vivo molecular profiling of disseminated prostate cancer: Cellular processing of [In-111]-labeled CHX-A "DTPA-trastuzumab and anti-HER2 ABY-025 Affibody in prostate cancer cell lines

Malmberg, Jennie; Tolmachev, Vladimir; Orlova, Anna

Part of Experimental and Therapeutic Medicine, p. 523-528, 2011

• DOI for Imaging agents for in vivo molecular profiling of disseminated prostate cancer: Cellular processing of [In-111]-labeled CHX-A "DTPA-trastuzumab and anti-HER2 ABY-025 Affibody in prostate cancer cell lines

Imaging agents for in vivo molecular profiling of disseminated prostate cancer - targeting EGFR receptors in prostate cancer: Comparison of cellular processing of [In-111]-labeled affibody molecule Z(EGFR:2377) and cetuximab

Malmberg, Jennie; Tolmachev, Vladimir; Orlova, Anna

Part of International Journal of Oncology, p. 1137-1143, 2011

• DOI for Imaging agents for in vivo molecular profiling of disseminated prostate cancer - targeting EGFR receptors in prostate cancer: Comparison of cellular processing of [In-111]-labeled affibody molecule Z(EGFR:2377) and cetuximab

Comparative biodistribution of imaging agents for in vivo molecular profiling of disseminated prostate cancer in mice bearing prostate cancer xenografts: focus on (111)In- and (125)I-labeled anti-HER2 humanized monoclonal trastuzumab and ABY-025 Affibody

Malmberg, Jennie; Sandström, Mattias; Wester, Kenneth; Tolmachev, Vladimir et al.

Part of Nuclear Medicine and Biology, p. 1093-1102, 2011

• DOI for Comparative biodistribution of imaging agents for in vivo molecular profiling of disseminated prostate cancer in mice bearing prostate cancer xenografts: focus on (111)In- and (125)I-labeled anti-HER2 humanized monoclonal trastuzumab and ABY-025 Affibody

Targeting of HER2-Expressing Tumors Using ¹¹¹In-ABY-025, a Second-Generation Affibody Molecule with a Fundamentally Reengineered Scaffold

Ahlgren, Sara; Orlova, Anna; Wållberg, Helena; Hansson, Monika et al.

Part of Journal of Nuclear Medicine, p. 1131-1138, 2010

• DOI for Targeting of HER2-Expressing Tumors Using ¹¹¹In-ABY-025, a Second-Generation Affibody Molecule with a Fundamentally Reengineered Scaffold

Evaluation of the Radiocobalt-Labeled [MMA-DOTA-Cys⁶¹]-Z_HER2:2395-Cys Affibody Molecule for Targeting of HER2-Expressing Tumors

Wållberg, Helena; Ahlgren, Sara; Widström, Charles; Orlova, Anna

Part of Molecular Imaging and Biology, p. 54-62, 2010

• DOI for Evaluation of the Radiocobalt-Labeled [MMA-DOTA-Cys⁶¹]-Z_HER2:2395-Cys Affibody Molecule for Targeting of HER2-Expressing Tumors

HEHEHE-Tagged Affibody Molecule May Be Purified by IMAC, Is Conveniently Labeled with [Tc-99m(CO)(3)](+), and Shows Improved Biodistribution with Reduced Hepatic Radioactivity Accumulation

Tolmachev, Vladimir; Hofström, Camilla; Malmberg, Jennie; Ahlgren, Sara et al.

Part of Bioconjugate chemistry, p. 2013-2022, 2010

• DOI for HEHEHE-Tagged Affibody Molecule May Be Purified by IMAC, Is Conveniently Labeled with [Tc-99m(CO)(3)](+), and Shows Improved Biodistribution with Reduced Hepatic Radioactivity Accumulation

Influence of an aliphatic linker between DOTA and synthetic Affibody molecule on targeting properties

Orlova, Anna; Feldwisch, Joachim; Tolmachev, Vladimir

Part of Nuclear Medicine and Biology, p. 695-695, 2010

• DOI for Influence of an aliphatic linker between DOTA and synthetic Affibody molecule on targeting properties

HER2 targeting with Tc-99m-labeled second generation synthetic Affibody molecule

Tolmachev, Vladimir; Wallberg, Helena; Feldwisch, Joachim; Orlova, Anna

Part of Nuclear Medicine and Biology, p. 705-706, 2010

• DOI for HER2 targeting with Tc-99m-labeled second generation synthetic Affibody molecule

HEHEHE: a new chelator for [Tc-99m(CO)(3)](+)-labeling assembling His(6)-tag in protein purification

Tolmachev, Vladimir; Hofström, Camilla; Malmberg, Jennie; Ahlgren, Sara et al.

Part of Nuclear Medicine and Biology, p. 698-698, 2010

• DOI for HEHEHE: a new chelator for [Tc-99m(CO)(3)](+)-labeling assembling His(6)-tag in protein purification

Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In- or 68Ga-labeled affibody molecules

Baum, Richard P; Prasad, Vikas; Müller, Dirk; Schuchardt, Christiane et al.

Part of Journal of Nuclear Medicine, p. 892-897, 2010

• DOI for Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In- or 68Ga-labeled affibody molecules

Influence of labelling methods on biodistribution and imaging properties of radiolabelled peptides for visualisation of molecular therapeutic targets

Tolmachev, Vladimir; Orlova, Anna

Part of Current Medicinal Chemistry, p. 2636-2655, 2010

• DOI for Influence of labelling methods on biodistribution and imaging properties of radiolabelled peptides for visualisation of molecular therapeutic targets

Re-186-maSGS-Z(HER2:342), a potential Affibody conjugate for systemic therapy of HER2-expressing tumours

Orlova, Anna; Tran, Thuy A; Ekblad, Torun; Karlström, Amelie Eriksson et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 260-269, 2010

• DOI for Re-186-maSGS-Z(HER2:342), a potential Affibody conjugate for systemic therapy of HER2-expressing tumours

Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR In-111-DOTA-Z(EGFR:2377) Affibody molecule: aspect of the injected tracer amount

Tolmachev, Vladimir; Rosik, Daniel; Wållberg, Helena; Sjöberg, Anna et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 613-622, 2010

• DOI for Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR In-111-DOTA-Z(EGFR:2377) Affibody molecule: aspect of the injected tracer amount

A HER2-binding Affibody molecule labelled with ⁶⁸Ga for PET imaging: direct in vivo comparison with the ¹¹¹In-labelled analogue

Tolmachev, Vladimir; Velikyan, Irina; Sandström, Mattias; Orlova, Anna

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 1356-1367, 2010

• DOI for A HER2-binding Affibody molecule labelled with ⁶⁸Ga for PET imaging: direct in vivo comparison with the ¹¹¹In-labelled analogue

Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

Göstring, Lovisa; Chew, Ming Tsuey; Orlova, Anna; Höidén-Guthenberg, Ingmarie et al.

Part of International Journal of Oncology, p. 757-763, 2010

• DOI for Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

Preparation and in vitro evaluation of 111In-CHX-A"-DTPA-labeled anti-VEGF monoclonal antibody bevacizumab.

Hosseinimehr, Seyed Jalal; Orlova, Anna; Tolmachev, Vladimir

Part of Human antibodies, p. 107-11, 2010

• DOI for Preparation and in vitro evaluation of 111In-CHX-A"-DTPA-labeled anti-VEGF monoclonal antibody bevacizumab.

Design, synthesis and biological evaluation of a multifunctional HER2-specific Affibody molecule for molecular imaging

Tran, Thuy A.; Rosik, Daniel; Abrahmsén, Lars; Sandström, Mattias et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 1864-1873, 2009

• DOI for Design, synthesis and biological evaluation of a multifunctional HER2-specific Affibody molecule for molecular imaging

Targeting of HER2-expressing tumors with a site-specifically 99mTc-labeled recombinant affibody molecule, ZHER2:2395, with C-terminally engineered cysteine

Ahlgren, Sara; Wållberg, Helena; Tran, Thuy A.; Widström, Charles et al.

Part of Journal of Nuclear Medicine, p. 781-789, 2009

• DOI for Targeting of HER2-expressing tumors with a site-specifically 99mTc-labeled recombinant affibody molecule, ZHER2:2395, with C-terminally engineered cysteine

The influence of Bz-DOTA and CHX-AaEuro(3)-DTPA on the biodistribution of ABD-fused anti-HER2 Affibody molecules: implications for In-114m-mediated targeting therapy

Tolmachev, Vladimir; Wallberg, Helena; Andersson, Karl; Wennborg, Anders et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 1460-1468, 2009

• DOI for The influence of Bz-DOTA and CHX-AaEuro(3)-DTPA on the biodistribution of ABD-fused anti-HER2 Affibody molecules: implications for In-114m-mediated targeting therapy

Synthesis and chemoselective intramolecular cross-linking of a HER2-binding Affibody

Ekblad, Torun; Tolmachev, Vladimir; Orlova, Anna; Lendel, Christofer et al.

Part of Biopolymers, p. 116-123, 2009

• DOI for Synthesis and chemoselective intramolecular cross-linking of a HER2-binding Affibody

On the selection of a tracer for PET imaging of HER2-expressing tumors: direct comparison of ¹²⁴I-labelled Affibody molecule and trastuzumab in a murine xenograft model

Orlova, Anna; Wållberg, Helena; Stone-Elander, Sharon; Tolmachev, Vladimir

Part of European Journal of Nuclear Medicine, p. 417-425, 2009

• DOI for On the selection of a tracer for PET imaging of HER2-expressing tumors: direct comparison of ¹²⁴I-labelled Affibody molecule and trastuzumab in a murine xenograft model

Affibody molecules for epidermal growth factor receptor targeting in vivo: aspects of dimerization and labeling chemistry

Tolmachev, Vladimir; Friedman, Mikaela; Sandström, Mattias; Eriksson, Tove L. et al.

Part of Journal of Nuclear Medicine, p. 274-283, 2009

• DOI for Affibody molecules for epidermal growth factor receptor targeting in vivo: aspects of dimerization and labeling chemistry

Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding

Tolmachev, Vladimir; Mume, Eskender; Sjöberg, Stefan; Frejd, Fredrik Y. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 692-701, 2009

• DOI for Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding

Positioning of Tc-99m-chelators influences radiolabeling, stability and biodistribution of Affibody molecules

Ekblad, Torun; Orlova, Anna; Feldwisch, Joachim; Wennborg, Anders et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 3912-3914, 2009

• DOI for Positioning of Tc-99m-chelators influences radiolabeling, stability and biodistribution of Affibody molecules

Update on Affibody molecules for in vivo imaging of targets for cancer therapy

Tolmachev, V; Orlova, A

Part of Minerva biotecnologica (Testo stampato), p. 21-30, 2009

Effects of lysine-containing mercaptoacetyl-based chelators on the biodistribution of ^99mTc-labeled anti-HER2 Affibody molecules

Tran, Thuy; Ekblad, Torun; Orlova, Anna; Sandström, Mattias et al.

Part of Bioconjugate chemistry, p. 2568-2576, 2008

• DOI for Effects of lysine-containing mercaptoacetyl-based chelators on the biodistribution of ^99mTc-labeled anti-HER2 Affibody molecules

In vivo and in vitro uptake of In-111, delivered with the affibody molecule(Z(EGFR:955))(2), in EGFR expressing tumour cells

Nordberg, Erika; Orlova, Anna; Friedman, M.; Tolmachev, Vladimir et al.

Part of Oncology Reports, p. 853-857, 2008

Targeting EGFR and HER2 with 211At-labeled molecules: unexpected and expected dose-effect relations in cultured tumor cells

Carlsson, Jörgen; Steffen, Ann-Charlott; Sundberg, Åsa L.; Vikström, Mikael et al.

Part of Current radiopharmaceuticals, p. 225-233, 2008

Slow internalization of anti-HER2 synthetic affibody monomer 111In-DOTA-ZHER2:342-pep2: implications for development of labeled tracers

Wållberg, Helena; Orlova, Anna

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 435-442, 2008

• DOI for Slow internalization of anti-HER2 synthetic affibody monomer 111In-DOTA-ZHER2:342-pep2: implications for development of labeled tracers

Evaluation of maleimide derivative of DOTA for site-specific labeling of recombinant affibody molecules

Ahlgren, Sara; Orlova, Anna; Rosik, Daniel; Sandström, Mattias et al.

Part of Bioconjugate chemistry, p. 235-243, 2008

• DOI for Evaluation of maleimide derivative of DOTA for site-specific labeling of recombinant affibody molecules

Evaluation of a maleimido derivative of CHX-A'' DTPA for site-specific labeling of affibody molecules

Tolmachev, Vladimir; Xu, Heng; Wållberg, Helena; Ahlgren, Sara et al.

Part of Bioconjugate chemistry, p. 1579-1587, 2008

• DOI for Evaluation of a maleimido derivative of CHX-A'' DTPA for site-specific labeling of affibody molecules

Development and preclinical characterisation of 99mTc-labelled Affibody molecules with reduced renal uptake

Ekblad, Torun; Tran, Thuy; Orlova, Anna; Widström, Charles et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 2245-2255, 2008

• DOI for Development and preclinical characterisation of 99mTc-labelled Affibody molecules with reduced renal uptake

Directed evolution to low nanomolar affinity of a tumor-targeting epidermal growth factor receptor-binding affibody molecule

Friedman, Mikaela; Orlova, Anna; Johansson, Eva; Eriksson, Tove L. J. et al.

Part of Journal of Molecular Biology, p. 1388-1402, 2008

• DOI for Directed evolution to low nanomolar affinity of a tumor-targeting epidermal growth factor receptor-binding affibody molecule

Imaging of HER2-expressing tumours using a synthetic Affibody molecule containing the 99mTc-chelating mercaptoacetyl-glycyl-glycyl-glycyl (MAG3) sequence

Engfeldt, Torun; Orlova, Anna; Tran, Thuy; Bruskin, Alexander et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 722-733, 2007

• DOI for Imaging of HER2-expressing tumours using a synthetic Affibody molecule containing the 99mTc-chelating mercaptoacetyl-glycyl-glycyl-glycyl (MAG3) sequence

In Vivo Evaluation of Cysteine-Based Chelators for Attachment of 99mTc  to Tumor-Targeting Affibody Molecules

Thuy, Tran; Engfeldt, Torun; Orlova, Anna; Widström, Charles et al.

Part of Bioconjugate chemistry, p. 549-558, 2007

• DOI for In Vivo Evaluation of Cysteine-Based Chelators for Attachment of 99mTc  to Tumor-Targeting Affibody Molecules
• Download full text (pdf) of In Vivo Evaluation of Cysteine-Based Chelators for Attachment of 99mTc  to Tumor-Targeting Affibody Molecules

Radionuclide therapy of HER2-positive microxenografts using a 177Lu-labeled HER2-specific Affibody molecule

Tolmachev, Vladimir; Orlova, Anna; Pehrson, Rikard; Galli, Joakim et al.

Part of Cancer Research, p. 2773-2782, 2007

• DOI for Radionuclide therapy of HER2-positive microxenografts using a 177Lu-labeled HER2-specific Affibody molecule

Labelling chemistry and characterization of [90Y/177Lu]-DOTA-ZHER2:342-3 Affibody molecule, a candidate agent for locoregional treatment of urinary bladder carcinoma

Fortin, Marc-André; Orlova, Anna; Malmström, Per-Uno; Tolmachev, Vladimir

Part of International Journal of Molecular Medicine, p. 285-291, 2007

Update: Affibody molecules for molecular imaging and therapy for cancer

Orlova, Anna; Feldwisch, Joachim; Abrahmsén, Lars; Tolmachev, Vladimir

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 573-584, 2007

• DOI for Update: Affibody molecules for molecular imaging and therapy for cancer

Evaluation of [(111/114m)In]CHX-A''-DTPA-ZHER2:342, an affibody ligand coniugate for targeting of HER2-expressing malignant tumors

Orlova, Anna; Rosik, Daniel; Sandström, Mattias; Lundqvist, Hans et al.

Part of The Quarterly Journal of Nuclear Medicine and Molecular Imaging, p. 314-323, 2007

Pre-clinical evaluation of [111In]-benzyl-DOTA-Z(HER2:342), a potential agent for imaging of HER2 expression in malignant tumors

Orlova, Anna; Tran, Thuy; Widström, Charles; Engfeldt, Torun et al.

Part of International Journal of Molecular Medicine, p. 397-404, 2007

(99m)Tc-maEEE-Z(HER2:342), an Affibody molecule-based tracer for the detection of HER2 expression in malignant tumors

Tran, Thuy; Engfeldt, Torun; Orlova, Anna; Sandström, Mattias et al.

Part of Bioconjugate chemistry, p. 1956-1964, 2007

• DOI for (99m)Tc-maEEE-Z(HER2:342), an Affibody molecule-based tracer for the detection of HER2 expression in malignant tumors

^99mTc-chelator engineering to improve tumour targeting properties of a HER2-specific Affibody molecule

Engfeldt, Torun; Tran, Thuy; Orlova, Anna; Widström, Charles et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 1843-1853, 2007

• DOI for ^99mTc-chelator engineering to improve tumour targeting properties of a HER2-specific Affibody molecule

Synthetic affibody molecules: a novel class of affinity ligands for molecular imaging of HER2-expressing malignant tumors

Orlova, Anna; Tolmachev, Vladimir; Pehrson, Rikard; Lindborg, Malin et al.

Part of Cancer Research, p. 2178-2186, 2007

• DOI for Synthetic affibody molecules: a novel class of affinity ligands for molecular imaging of HER2-expressing malignant tumors

Comparison of benzoate- and dodecaborate-based linkers for attachment of radioiodine to HER2-targeting Affibody ligand

Tran, Thuy; Orlova, Anna; Sivaev, Igor; Sandström, Mattias et al.

Part of International Journal of Molecular Medicine, p. 485-493, 2007

111In-benzyl-DTPA-ZHER2:342, an affibody-based conjugate for in vivo imaging of HER2 expression in malignant tumors

Tolmachev, Vladimir; Nilsson, Fredrik Y.; Widström, Charles; Andersson, Karl et al.

Part of Journal of Nuclear Medicine, p. 846-53, 2006

Cellular processing in the SW1222 cell line of mAb A33 directly and indirectly radiohalogenated

Höglund, Johanna; Orlova, Anna; Sundin, Anders; Lundqvist, Hans et al.

Part of Oncology Reports, p. 159-63, 2006

Radio-iodination of monoclonal antibody using potassium [125I]-(4-isothiocyanatobenzylammonio)-iodo-decahydro-closo-dodecaborate (iodo-DABI)

Orlova, Anna; Bruskin, Alexander; Sivaev, Igor; Sjöberg, Stefan et al.

Part of Anticancer Research, p. 1217-23, 2006

Tumor imaging using a picomolar affinity HER2 binding affibody molecule

Orlova, Anna; Magnusson, Mikaela; Eriksson, Tove L. J.; Nilsson, Martin et al.

Part of Cancer Research, p. 4339-48, 2006

• DOI for Tumor imaging using a picomolar affinity HER2 binding affibody molecule

Affibody-mediated tumour targeting of HER-2 expressing xenografts in mice

Steffen, Ann-Charlott; Orlova, Anna; Wikman, Maria; Nilsson, Fredrik Y. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 631-638, 2006

• DOI for Affibody-mediated tumour targeting of HER-2 expressing xenografts in mice

Comparative in vivo evaluation of technetium and iodine labels on an anti-HER2 affibody for single-photon imaging of HER2 expression in tumors

Orlova, Anna; Nilsson, Fredrik Y.; Wikman, Maria; Widström, Charles et al.

Part of Journal of Nuclear Medicine, p. 512-519, 2006

An aminoacridine derivative for radionuclide therapy: DNA binding properties studied in a novel cell-free in vitro assay

Kullberg, Erika Bohl; Stenerlöw, Bo; Ghirmai, Senait; Lundqvist, Hans et al.

Part of International Journal of Oncology, p. 1355-60, 2005

An Aminoacridine Derivative for Radionuclide Therapy: Dna-Binding Properties Studied in a Novel Cell-Free in vitro Assay

Kullberg, E-B.; Stenerlöw, B.; Ghirmait, Senait; Lundqvist, Hans et al.

Part of Int. J. Onc., p. 1355-1360, 2005

Evaluation of ((4-Hydroxyphenyl)ethyl)maleimide for Site-Specific Radiobromination of Anti-HER2 Affibody

Mume, Eskender; Orlova, Anna; Larsson, Barbro; Nilsson, Ann-Sofie et al.

Part of Bioconjugate chemistry, p. 1547-1555, 2005

• DOI for Evaluation of ((4-Hydroxyphenyl)ethyl)maleimide for Site-Specific Radiobromination of Anti-HER2 Affibody

[99mTc] HYNIC-hEGF, a potential agent for imaging of EGF receptors in vivo: preparation and pre-clinical evaluation

Babaei, Mohammad Hossein; Almqvist, Ylva; Orlova, Anna; Shafii, Mohammad et al.

Part of Oncology Reports, p. 1169-75, 2005

In vitro characterization of 211 At-labeled antibody A33: a potential therapeutic agent against metastatic colorectal carcinoma

Almqvist, Ylva; Orlova, Anna; Sjöström, Anna; Jensen, Holger J. et al.

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 514-523, 2005

• DOI for In vitro characterization of 211 At-labeled antibody A33: a potential therapeutic agent against metastatic colorectal carcinoma

Radiobromination of humanized anti-HER2 monoclonal antibody trastuzumab using N-succinimidyl 5-bromo-3-pyridinecarboxylate, a potential label for immunoPET

Mume, Eskender; Orlova, Anna; Malmström, Per-Uno; Lundqvist, Hans et al.

Part of Nuclear Medicine and Biology, p. 613-22, 2005

• DOI for Radiobromination of humanized anti-HER2 monoclonal antibody trastuzumab using N-succinimidyl 5-bromo-3-pyridinecarboxylate, a potential label for immunoPET

Comparative biodistribution of potential anti-glioblastoma conjugates [111In]DTPA-hEGF and [111In]Bz-DTPA-hEGF in normal mice

Tolmachev, Vladimir; Orlova, Anna; Wei, Qichun; Bruskin, Alexander et al.

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 491-501, 2004

• DOI for Comparative biodistribution of potential anti-glioblastoma conjugates [111In]DTPA-hEGF and [111In]Bz-DTPA-hEGF in normal mice

[177Lu]Bz-DTPA-EGF: Preclinical characterization of a potential radionuclide targeting agent against glioma

Sundberg, Åsa Liljegren; Gedda, Lars; Orlova, Anna; Bruskin, Alexander et al.

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 195-204, 2004

• DOI for [177Lu]Bz-DTPA-EGF: Preclinical characterization of a potential radionuclide targeting agent against glioma

Targeting against epidermal growth factor receptors: Cellular processing of astatinated EGF after binding to cultured carcinoma cells

Orlova, Anna; Sjöström, Anna; Lebeda, Ondrej; Lundqvist, Hans et al.

Part of Anticancer Research, p. 4035-4042, 2004

Targeting of a head and neck squamous cell carcinoma xenograft model using the chimeric monoclonal antibody U36 radioiodinated with a closo-dodecaborate-containing linker

Cheng, Junping; Persson, Mikael; Tolmachev, Vladimir; Siavaev, Igor et al.

Part of Acta Oto-Laryngologica, p. 1078-85, 2004

Copper-mediated isotopic exchange between [125I]iodide and bis(triethylammonium) undecahydro-12-iodo-closo-dodecaborate in aqueous media

Schukin, E.; Orlova, Anna; Korsakov, M.; Sjöberg, Stefan et al.

Part of Journal of Radioanalytical and Nuclear Chemistry, p. 295-299, 2004

• DOI for Copper-mediated isotopic exchange between [125I]iodide and bis(triethylammonium) undecahydro-12-iodo-closo-dodecaborate in aqueous media

Synthesis and Radioiodination of Some 9-Aminoacridine Derivatives

Ghirmai, Senait; Mume, Eskender; Henssen, Cecile; Ghaneolhusseini, Hadi et al.

Part of European Journal of Organic Chemistry, p. 3719-3725, 2004

• DOI for Synthesis and Radioiodination of Some 9-Aminoacridine Derivatives

Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB1 H11: Aspects of labelling chemistry in aqueous solution using Chloramine-T

Orlova, Anna; Sivaev, I.; Sjöberg, Stefan; Lundqvist, Hans et al.

Part of Radiochimica Acta, p. 311, 2004

Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with 211At-EGF

Sundberg, Åsa Liljegren; Almqvist, Ylva; Orlova, Anna; Blomquist, Erik et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 1348-56, 2003

• DOI for Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with 211At-EGF

[111In]Bz-DTPA-hEGF: Preparation and in vitro characterization of a potential anti-glioblastoma targeting agent

Sundberg, Åsa Liljegren; Orlova, Anna; Bruskin, Alexander; Gedda, Lars et al.

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 643-54, 2003

• DOI for [111In]Bz-DTPA-hEGF: Preparation and in vitro characterization of a potential anti-glioblastoma targeting agent

Feasibility of isotopic exchange in system [125I] iodide – undecahydro-iodo-closo-dodecaborate (2-) anion

Korsakov, M. V.; Shchukin, E. V.; Korsakova, L. N.; Orlova, Anna M. et al.

Part of Journal of Radioanalytical and Nuclear Chemistry, p. 67-71, 2003

Approaches to improve cellular retention of radiohalogen labels delivered by internalising tumour-targeting proteins and peptides

Tolmachev, Vladimir; Orlova, Anna; Lundqvist, Hans

Part of Current Medicinal Chemistry, p. 2447-60, 2003

Comparative biodistribution of the radiohalogenated (Br, I and At) antibody A33: Implications for in vivo dosimetry

Orlova, Anna; Höglund, Johanna; Lubberink, Mark; Lebeda, Ondrej et al.

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 385-96, 2002

• DOI for Comparative biodistribution of the radiohalogenated (Br, I and At) antibody A33: Implications for in vivo dosimetry

Preparation of [76Br] 5-bromo-2-thiouracil, a positron-emitting melanoma loclizing agent

Tolmachev, Vladimir; Orlova, Anna; Sundin, A

Part of Journal of Radioanalytical and Nuclear Chemistry, p. 409-441, 2002

Cellular processing of (125)I- and (111)in-labeled epidermal growth factor(EGF) bound to cultured A431 tumor cells

Orlova, Anna; Bruskin, Alexander; Sjöström, Anna; Lundqvist, Hans et al.

Part of Nuclear Medicine and Biology, p. 827-35, 2000

• DOI for Cellular processing of (125)I- and (111)in-labeled epidermal growth factor(EGF) bound to cultured A431 tumor cells

Optimized indirect (76)Br-bromination of antibodies using N-succinimidyl para-[76Br]bromobenzoate for radioimmuno PET

Höglund, Johanna; Tolmachev, Vladimir; Orlova, Anna; Lundqvist, Hans et al.

Part of Nuclear Medicine and Biology, p. 837-43, 2000

• DOI for Optimized indirect (76)Br-bromination of antibodies using N-succinimidyl para-[76Br]bromobenzoate for radioimmuno PET

Optimization of iodination of [125I]-N-succinimidyl-para-iodobenzoate using Chloromine-T for labeling of proteins

Tolmachev, Vladimir; Orlova, Anna; Lundqvist, Hans

Part of Journal of Radioanalytical and Nuclear Chemistry, p. 207-213, 2000

Closo-dodecaborate(2-)anion as a potential prosthetic group for attachment of astatine to proteins: Aspects of the labelling chemistry with Chloramine -T

Orlova, Anna; Lebeda, Ondrej; Tolmachev, Vladimir; Sjöberg, Stefan et al.

Part of Journal of labelled compounds & radiopharmaceuticals, p. 251-260, 2000

Closo-dodecaborate(2-) as a linker for iodination of macromolecules: Aspects on conjugation chemistry and biodistribution

Tolmachev, Vladimir; Koziorowski, Jacek; Sivaev, Igor; Lundqvist, Hans et al.

Part of Bioconjugate chemistry, p. 338-45, 1999

• DOI for Closo-dodecaborate(2-) as a linker for iodination of macromolecules: Aspects on conjugation chemistry and biodistribution

Labelling of boron containing compounds with halogen isotopes

Tolmachev, Vladimir; Lundqvist, Hans; Sivaev, Igor; Orlova, Anna et al.

Part of Journal of labelled compounds & radiopharmaceuticals, p. 122, 1997

Labelling and in vivo evaluation of closo-dodecaborate as a linker for attachment of iodine to radiopharma-ceuticals

Tolmachev, Vladimir; Lundqvist, Hans; Carlsson, Jörgen; Sivaev, Igor et al.

Part of Journal of labelled compounds & radiopharmaceuticals, p. 125-127, 1997

• DOI for Labelling and in vivo evaluation of closo-dodecaborate as a linker for attachment of iodine to radiopharma-ceuticals

The Performance of FDA-Approved PET Imaging Agents in the Detection of Prostate Cancer

Li, Mei; Zelchan, Roman; Orlova, Anna

Part of Biomedicines, 2022

• DOI for The Performance of FDA-Approved PET Imaging Agents in the Detection of Prostate Cancer
• Download full text (pdf) of The Performance of FDA-Approved PET Imaging Agents in the Detection of Prostate Cancer

PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology

Rinne, Sara S.; Orlova, Anna; Tolmachev, Vladimir

Part of International Journal of Molecular Sciences, 2021

• DOI for PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology
• Download full text (pdf) of PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology

The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer

Tolmachev, Vladimir; Orlova, Anna; Sörensen, Jens

Part of Seminars in Cancer Biology, p. 185-197, 2021

• DOI for The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer

Affibody Molecules as Targeting Vectors for PET Imaging

Tolmachev, Vladimir; Orlova, Anna

Part of Cancers, 2020

• DOI for Affibody Molecules as Targeting Vectors for PET Imaging
• Download full text (pdf) of Affibody Molecules as Targeting Vectors for PET Imaging

Radiolabeled GRPR Antagonists for Imaging of Disseminated Prostate Cancer: Influence of Labeling Chemistry on Targeting Properties

Mitran, Bogdan; Tolmachev, Vladimir; Orlova, Anna

Part of Current Medicinal Chemistry, p. 7090-7111, 2020

• DOI for Radiolabeled GRPR Antagonists for Imaging of Disseminated Prostate Cancer: Influence of Labeling Chemistry on Targeting Properties

Radiolabelled receptor-tyrosine-kinase targeting drugs for patient stratification and monitoring of therapy response: prospects and pitfalls

Tolmachev, Vladimir; Stone-Elander, Sharon; Orlova, Anna

Part of The Lancet Oncology, p. 992-1000, 2010

• DOI for Radiolabelled receptor-tyrosine-kinase targeting drugs for patient stratification and monitoring of therapy response: prospects and pitfalls

Affibody molecules: potential for in vivo imaging of molecular targets for cancer therapy

Tolmachev, Vladimir; Orlova, Anna; Nilsson, Fredrik Y.; Feldwisch, Joachim et al.

Part of Expert Opinion on Biological Therapy, p. 555-568, 2007

• DOI for Affibody molecules: potential for in vivo imaging of molecular targets for cancer therapy

Methods for radiolabelling of monoclonal antibodies

Tolmachev, Vladimir; Orlova, Anna; Andersson, Karl

Part of Human Monoclonal Antibodies, p. 309-330, Humana Press, 2014

• DOI for Methods for radiolabelling of monoclonal antibodies
• Download full text (pdf) of Methods for radiolabelling of monoclonal antibodies

Radiohalogenated Polyhedral Borate Anaions for use in Targeted Oncological Radionuclide Therapy, Some Recent Developments

Tolmachev, V.; Bruskin, A.; Orlova, A.; Winberg, K.J. et al.

Part of Boron Chemistry at the Beginning of the 21st Century. Y.N Bubnov, p. 338-3342, Editoral URSS, Scientific Literature and Textbooks,, Moscow, 2003

Effect of ionizing radiation on the labeling of closo-dodecaborate(2-) anion with 125I

Lebeda, Ondrej; Orlova, Anna; Tolmachev, Vladimir; Lundqvist, Hans et al.

Part of Contemporary Boron Chemistry, Royal Society of Medicine Press, 2000

• DOI for Effect of ionizing radiation on the labeling of closo-dodecaborate(2-) anion with 125I

Effect of ionising radiation on the labelling of closo-dodecaborate (2-) anion

Lebeda, Ondrej; Orlova, Anna; Tolmachev, Vladimir; Lundqvist, Hans et al.

Part of Contemporary Boron Chemistry, p. 148-154, Royal Society of Chemistry, 2000

Closo-dodecaborate (2-) anion as a prosthetic group for labelling proteins with a astatine

Orlova, Anna; Lebeda, O.; Tolmachev, Vladimir; Sjöberg, S. et al.

Part of Contemporary Boron Chemistry, p. 144-147, Royal Society of Chemistry, 2000

Polyhedral boron clasters as linkers for attachment of radiohalogens to tumor targeting proteins. II. Radioiodination of monoclonal antibody using potassium [125I]-4-(isothiocyanatobenzylammonio)-iodo-decahydro-closo-dodecaborate (Iodo-DABI)

Orlova, Anna; Bruskin, Alexander; Sivaev, Igor; Sjoberg, Stefan et al.

Pharmacokinetics in tumour-bearing rats of directly and indirectly ⁷⁶Br-brominated MAb A33: Comparison with ¹²⁵I-iodinated counterparts

Höglund, Johanna; Tolmachev, Vladimir; Orlova, Anna; Lundqvist, Hans et al.

Synthesis and Preclinical Evaluation of GRPR Antagonist [¹⁸F]-MeTz-PEG₂-RM26 for Position Emission Tomography

Lundmark, Fanny; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Tolmachev, Vladimir et al.

Radio-iodination of monoclonal antibody using potassium [125I]-(4-isothiocyanatobenzylammonio)-iodo-decahydro-closo-dodecaborate (iodo-DABI)

Orlova, Anna; Bruskin, Alexander; Sivaev, Igor; Sjöberg, Stefan et al.

Part of Anticancer Research, p. 1217-1223, 2006

Cellular processing of iodinated and astatinated trastuzumab in cultured SK-BR-3 breast cancer cells

Persson, Mikael; Orlova, Anna; Gedda, Lars; Carlsson, Jörgen et al.

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 353-354, 2002

[111In]-DTPA-hEGF and [111In]-Bz-DTPA-hEGF: preparation and in vitro studies of two anti- glioblastoma conjugates with residualising labels

Liljegren Sundberg, Åsa; Orlova, Anna; Bruskin, Alexander; Gedda, Lars et al.

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 354-354, 2002

[111In] benzyl-DTPA-EGF, a new potential radiopeptide for targeting of glioma

Orlova, Anna; Sundberg, Å.; Bruskin, Alexander; Gedda, Lars et al.

Part of European Journal of Nuclear Medicine, 2002

The use of benzyl isothiocyanate derivative of closo-dodecaborate dianion for indirect radioiodination and radiobromination of monoclonal antibodies

Tolmachev, Vladimir; Orlova, Anna; Bruskin, Alexander; Sivaev, Igor et al.

Part of European Journal of Nuclear Medicine, 2002

Pharmacokinetics in tumour-bearing rats of directly and indirectly 76Br-brominated MAb A33: Comparison with 125I-iodinated counterparts

Höglund, Johanna; Orlova, Anna; Tolmachev, Vladimir; Lundqvist, Hans et al.

2002

Cellular processing of indirectly astatinated and iodinated mAb A33 in SW1222 cultured cells

Orlova, Anna; Sjöström, Anna; Ericson, A.; Lebeda, Ondrej et al.

Part of Journal of labelled compounds & radiopharmaceuticals, 2001

• DOI for Cellular processing of indirectly astatinated and iodinated mAb A33 in SW1222 cultured cells

Synthesis of [211At] N-[8-(acridin-9-ylamino)-octyl]-3- astatobenzamide, an astatinated DNA intercalator

Orlova, Anna; Bohl, E.; Ghaneolhosseino, H.; Gedda, Lars et al.

Part of European Journal of Nuclear Medicine, p. 317, 2000

Cellular processing of ¹²⁵I- and ¹¹¹in-labeled epidermal growth factor (EGF) bound to cultured A431 tumor cells

Orlova, Anna; Bruskin, Alexander; Sjöström, Anna; Lundqvist, Hans et al.

Part of Nuclear Medicine and Biology, p. 827-835, 2000

• DOI for Cellular processing of ¹²⁵I- and ¹¹¹in-labeled epidermal growth factor (EGF) bound to cultured A431 tumor cells

Intercalators labelled with Auger emitting nuclides

Lundqvist, Hans; Stenerlöw, Bo; Tolmachev, Vladimir; Orlova, Anna et al.

1999