Maija-Leena Eloranta
Researcher at Department of Medical Sciences; Rheumatology
- Telephone:
- +46 18 471 45 42
- Mobile phone:
- +46 70 396 51 73
- E-mail:
- Maija-Leena.Eloranta@medsci.uu.se
- Visiting address:
- Rudbecklaboratoriet C11
SE-751 85 Uppsala
Sweden - Postal address:
- Rudbecklaboratoriet, C11
SE-751 85 Uppsala
Sweden
- Academic merits:
- Associate professor
Publications
Recent publications
Part of RMD Open, 2023
- DOI for Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
- Download full text (pdf) of Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
Part of RMD Open, 2023
- DOI for Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
- Download full text (pdf) of Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
Part of Lupus Science and Medicine, 2023
- DOI for B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
- Download full text (pdf) of B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
Part of Annals of the Rheumatic Diseases, p. 754-762, 2023
Part of Arthritis & Rheumatology, p. 1440-1450, 2022
- DOI for Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
- Download full text (pdf) of Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
All publications
Articles in journal
Part of Lupus Science and Medicine, 2023
- DOI for B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
- Download full text (pdf) of B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
Part of Annals of the Rheumatic Diseases, p. 754-762, 2023
Part of Arthritis & Rheumatology, p. 1440-1450, 2022
- DOI for Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
- Download full text (pdf) of Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease
Part of Lupus Science and Medicine, 2022
- DOI for Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease
- Download full text (pdf) of Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease
Part of Nature Communications, 2022
- DOI for Genome-wide association study identifies Sjogren's risk loci with functional implications in immune and glandular cells
- Download full text (pdf) of Genome-wide association study identifies Sjogren's risk loci with functional implications in immune and glandular cells
Part of Arthritis & Rheumatology, p. 1842-1850, 2022
- DOI for Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome
- Download full text (pdf) of Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome
Different chest HRCT scan protocols change the extent of ground glass opacities
Part of BMC Pulmonary Medicine, 2022
- DOI for Different chest HRCT scan protocols change the extent of ground glass opacities
- Download full text (pdf) of Different chest HRCT scan protocols change the extent of ground glass opacities
Contributions of de novo variants to systemic lupus erythematosus
Part of European Journal of Human Genetics, p. 184-193, 2021
- DOI for Contributions of de novo variants to systemic lupus erythematosus
- Download full text (pdf) of Contributions of de novo variants to systemic lupus erythematosus
DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome
Part of Frontiers in Immunology, 2021
- DOI for DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome
- Download full text (pdf) of DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome
Part of Frontiers in Immunology, 2021
- DOI for C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
- Download full text (pdf) of C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
Part of Annals of the Rheumatic Diseases, p. 109-117, 2021
- DOI for Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
- Download full text (pdf) of Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
Part of Frontiers in Immunology, 2021
- DOI for Comparison of Surrogate Markers of the Type I Interferon Response and Their Ability to Mirror Disease Activity in Systemic Lupus Erythematosus
- Download full text (pdf) of Comparison of Surrogate Markers of the Type I Interferon Response and Their Ability to Mirror Disease Activity in Systemic Lupus Erythematosus
Part of Rheumatology, p. 3461-3470, 2021
- DOI for Identification and Functional Characterization of a Novel Susceptibility Locus for Small Vessel Vasculitis with MPO-ANCA
- Download full text (pdf) of Identification and Functional Characterization of a Novel Susceptibility Locus for Small Vessel Vasculitis with MPO-ANCA
Part of Annals of the Rheumatic Diseases, p. 363-369, 2020
- DOI for High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
- Download full text (pdf) of High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero
Part of RMD Open, 2020
- DOI for Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero
- Download full text (pdf) of Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero
Part of Arthritis Research & Therapy, 2020
- DOI for The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells
- Download full text (pdf) of The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells
Part of Scandinavian Journal of Immunology, 2020
- DOI for Activation of plasmacytoid dendritic cells and B cells with two structurally different Toll-like receptor 7 agonists
- Download full text (pdf) of Activation of plasmacytoid dendritic cells and B cells with two structurally different Toll-like receptor 7 agonists
Part of PLOS Genetics, 2020
- DOI for Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling
- Download full text (pdf) of Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling
Part of Human Genetics, p. 141-150, 2019
- DOI for Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
- Download full text (pdf) of Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
Part of Rheumatology, p. 918-919, 2019
Part of Annals of the Rheumatic Diseases, p. 1363-1370, 2019
- DOI for Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus
- Download full text (pdf) of Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus
Part of European Journal of Human Genetics, p. 432-441, 2019
- DOI for A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts
- Download full text (pdf) of A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts
Part of Annals of the Rheumatic Diseases, p. 736-743, 2018
- DOI for DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus
- Download full text (pdf) of DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus
Part of Scandinavian Journal of Immunology, 2018
- DOI for Transcription profiling of peripheral B cells in antibody-positive primary Sjogren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature
- Download full text (pdf) of Transcription profiling of peripheral B cells in antibody-positive primary Sjogren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature
T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus
Part of Journal of Autoimmunity, p. 28-38, 2018
- DOI for T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus
- Download full text (pdf) of T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus
Interleukin-22 and associated genes are targets of microRNAs dysregulated
Part of Clinical and Experimental Rheumatology, 2018
Part of Annals of the Rheumatic Diseases, p. 1063-1069, 2018
- DOI for Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis
- Download full text (pdf) of Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis
Part of Annals of the Rheumatic Diseases, p. 1070-1077, 2018
- DOI for The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
- Download full text (pdf) of The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
Part of Arthritis Research & Therapy, 2018
- DOI for Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor
- Download full text (pdf) of Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor
Part of Human Gene Therapy, 2018
ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
Part of Scientific Reports, 2018
- DOI for ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
- Download full text (pdf) of ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
Part of Clinical and Experimental Immunology, p. 83-91, 2017
Novel risk genes for systemic lupus erythematosus predicted by random forest classification
Part of Scientific Reports, 2017
- DOI for Novel risk genes for systemic lupus erythematosus predicted by random forest classification
- Download full text (pdf) of Novel risk genes for systemic lupus erythematosus predicted by random forest classification
Type I IFN System Activation In Newborns Exposed To ANTI-RO/SSA Autoantibodies In Utero
Part of Annals of the Rheumatic Diseases, p. 182-182, 2017
High Genetic Risk Score Is Associated with Increased Organ Damage in SLE
Part of Arthritis & Rheumatology, 2017
Type I IFN System Activation In Newborns Exposed To Anti-Ro/Ssa Autoantibodies In Utero
Part of Annals of the Rheumatic Diseases, 2017
Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus
Part of Arthritis & Rheumatology, 2017
Part of Arthritis & Rheumatology, 2017
Part of PLOS Genetics, 2017
- DOI for Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons
- Download full text (pdf) of Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons
Part of PLOS ONE, 2017
- DOI for Plasmacytoid dendritic cells and RNA-containing immune complexes drive expansion of peripheral B cell subsets with an SLE-like phenotype
- Download full text (pdf) of Plasmacytoid dendritic cells and RNA-containing immune complexes drive expansion of peripheral B cell subsets with an SLE-like phenotype
Activated Plasmacytoid Dendritic Cells (PDCS) Alter The Composition of The Blood B Cell Subsets
Part of Annals of the Rheumatic Diseases, p. 179-179, 2016
Part of Annals of the Rheumatic Diseases, p. 277-277, 2016
Part of Annals of the Rheumatic Diseases, p. 2029-2036, 2016
- DOI for Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes
- Download full text (pdf) of Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes
Cause and consequences of the activated type I interferon system in SLE
Part of Journal of Molecular Medicine, p. 1103-1110, 2016
- DOI for Cause and consequences of the activated type I interferon system in SLE
- Download full text (pdf) of Cause and consequences of the activated type I interferon system in SLE
Part of Arthritis & Rheumatology, p. 1045-1045, 2016
Part of Annals of the Rheumatic Diseases, p. 1728-1734, 2016
Part of Molecular Medicine, p. 322-328, 2016
- DOI for Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study.
- Download full text (pdf) of Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study.
Part of Human Genetics, p. 485-497, 2016
- DOI for Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression
- Download full text (pdf) of Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression
Genome-Wide Analysis of DNA Methylation Profiles in Multiple Tissues in Primary Sjogren's Syndrome
Part of Scandinavian Journal of Immunology, p. 412-412, 2015
Genome-wide analysis of DNA methylation in systemic lupus erythematosus
Part of Clinical and Experimental Rheumatology, 2015
Part of Human Molecular Genetics, p. 3571-3581, 2015
Identification of Novel Sjogren's Syndrome Risk Loci in the Regions of TNFAIP3 and PRDM1
Part of Arthritis & Rheumatology, 2015
Part of ARTHRITIS & RHEUMATOLOGY, p. 1000-1011, 2015
Part of Arthritis & Rheumatology, 2015
Part of Arthritis & Rheumatology, 2014
Genome-Wide DNA Methylation Analysis of CD19+B Cells in Primary Sjogren's Syndrome
Part of Arthritis & Rheumatology, 2014
High-Throughput Sequencing of 219 Candidate Genes for Identification of SLE-Associated Risk Variants
Part of Arthritis & Rheumatology, 2014
Part of Scandinavian Journal of Rheumatology, p. 88-89, 2014
Part of Scandinavian Journal of Rheumatology, p. 92-92, 2014
An NFKB1 gene promoter polymorphism is associated with primary Sjogren's syndrome
Part of Scandinavian Journal of Rheumatology, p. 87-88, 2014
Part of Arthritis & rheumatology, p. 1568-1573, 2014
Part of Arthritis and Rheumatism, p. 2424-2429, 2013
NCR3/NKp30 Contributes to Pathogenesis in Primary Sjögren's Syndrome
Part of Science Translational Medicine, 2013
Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus
Part of Rheumatology, p. 1818-1823, 2013
Part of Arthritis and Rheumatism, p. 2216, 2013
RNA-Seq for Enrichment and Analysis of IRF5 Transcript Expression in SLE
Part of PLOS ONE, p. 54487, 2013
- DOI for RNA-Seq for Enrichment and Analysis of IRF5 Transcript Expression in SLE
- Download full text (pdf) of RNA-Seq for Enrichment and Analysis of IRF5 Transcript Expression in SLE
Two rare disease-associated tyk2 variants are catalytically impaired but signaling competent
Part of Journal of Immunology, p. 2335-2344, 2013
Part of Arthritis and Rheumatism, p. 853-863, 2013
Part of Nature Genetics, p. 1284-1292, 2013
Association of genes in the NF-κB pathway with antibody positive primary Sjögren's syndrome
Part of Scandinavian Journal of Immunology, p. 447-454, 2013
Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia
Part of Genome Biology, 2013
Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility
Part of Genes and Immunity, p. 217-222, 2013
- DOI for Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility
- Download full text (pdf) of Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility
Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations
Part of European Journal of Human Genetics, p. 994-999, 2013
Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis
Part of PLOS ONE, 2013
- DOI for Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis
- Download full text (pdf) of Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis
Part of Annals of the Rheumatic Diseases, p. 96-103, 2013
Part of Journal of Immunology, p. 2989-2998, 2013
Part of Circulation, p. 255-263, 2013
The NKp30/B7H6 Axis Contributes To Pathogenesis In Primary Sjogren's Syndrome.
Part of Arthritis and Rheumatism, 2013
On the Origin of the Type I Interferon Activity in Rheumatoid Arthritis
Part of Annals of the Rheumatic Diseases, 2013
Part of Annals of the Rheumatic Diseases, p. 270-270, 2013
Part of Lupus, p. 586-595, 2012
SLE immune complexes upregulate the expression of slamf7 (cd319) on plasmacytoid dendritic cells
Part of Annals of the Rheumatic Diseases, 2012
Part of Arthritis and Rheumatism, p. 788-798, 2012
B lymphocytes enhance the interferon-α production by plasmacytoid dendritic cells
Part of Arthritis and Rheumatism, p. 3409-3419, 2012
On the Origin of the Type I Interferon Signature in Rheumatoid Arthritis
Part of Arthritis and Rheumatism, 2012
Part of Arthritis and Rheumatism, 2012
Part of Arthritis and Rheumatism, 2012
Part of Arthritis and Rheumatism, 2012
Part of Journal of Immunology, p. 5085-5094, 2011
Part of Arthritis Research & Therapy, 2011
- DOI for Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
- Download full text (pdf) of Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome
Part of Genes and Immunity, p. 100-109, 2011
Part of European Journal of Human Genetics, p. 479-484, 2011
Part of Connective Tissue Research, p. 290-300, 2011
Part of Annals of the Rheumatic Diseases, p. 1396-1402, 2010
Part of Arthritis and Rheumatism, p. 562-573, 2010
Part of Arthritis and Rheumatism, p. 3755-3760, 2009
Part of Arthritis and Rheumatism, p. 3081-3090, 2009
Part of Research in Veterinary Science, p. 490-497, 2009
Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE
Part of European Journal of Immunology, p. 2925-2935, 2009
Part of Arthritis and Rheumatism, p. 2418-2427, 2009
Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome
Part of Genes and Immunity, p. 68-76, 2009
Part of Immunology, p. 140-6, 2009
Part of Journal of Experimental Medicine, p. 1661-1671, 2009
Part of Human Molecular Genetics, p. 872-881, 2008
Part of Human Molecular Genetics, p. 2868-2876, 2008
Part of Journal of Clinical Immunology, p. 220-31, 2008
Part of Arthritis and Rheumatism, p. 3112-3124, 2007
Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology
Part of Journal of Veterinary Medicine A, p. 346-351, 2007
Part of Arthritis and Rheumatism, p. 1917-1927, 2006
Part of Arthritis and Rheumatism, p. 1185-1195, 2005
Part of American Journal of Human Genetics, p. 528-537, 2005
Part of Journal of Biological Chemistry, p. 33411-33418, 2005
Part of Arthritis and Rheumatism, p. 1861-1872, 2004
Part of Journal of Immunology, p. 3296-302, 2003
Part of Science of the Total Environment, p. 37-47, 2002
Presence of cutaneous interferon-alpha producing cells in patients with systemic lupus erythematosus
Part of Lupus, p. 484-90, 2001
Articles, review/survey
Part of RMD Open, 2023
- DOI for Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
- Download full text (pdf) of Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
Part of RMD Open, 2023
- DOI for Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
- Download full text (pdf) of Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
The interferon signature in autoimmune diseases
Part of Current Opinion in Rheumatology, p. 248-253, 2013
Primary Sjögren's syndrome and the type I interferon system
Part of Current Pharmaceutical Biotechnology, p. 2054-2062, 2012
The type I interferon system in the development of lupus
Part of Seminars in Immunology, p. 113-121, 2011
Part of Current Opinion in Rheumatology, p. 471-477, 2009
Endogenous type I interferon inducers in autoimmune diseases
Part of Autoimmunity, p. 349-352, 2009
Chapters in book
The interferons. Further targeted therapies in rheumatology
Part of Informa Healthcare, 2007