Maija-Leena Eloranta

Single-cell RNA-seq reveals a persistent interferon signature in immune cells from systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatment

Sayadi, Ahmed; Eloranta, Maija-Leena; Oparina, Nina Y.; Wallgren, Marcus et al.

Part of Journal of Autoimmunity, 2026

DOI for Single-cell RNA-seq reveals a persistent interferon signature in immune cells from systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatment
Download full text (pdf) of Single-cell RNA-seq reveals a persistent interferon signature in immune cells from systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatment

Innate immune cell subsets are enriched in synovial fluid of ACPA-negative rheumatoid arthritis and characterized by distinct type I IFN gene signatures

Argyriou, Alexandra; Wadsworth, Marc H.; Fienman, Joshua; Gonzalez-Sanchez, Ana Cristina et al.

Part of Annals of the Rheumatic Diseases, p. 265-275, 2026

Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Part of Scientific Reports, 2026

Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland

Wiley, Mandi M.; Radziszewski, Marcin; Khatri, Bhuwan; Joachims, Michelle L. et al.

Part of Annals of the Rheumatic Diseases, p. 1512-1527, 2025

DOI for Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland

Patients with systemic lupus erythematosus (SLE) have an increased bisphenol A methylation score linked to SLE risk genes and selected clinical subphenotypes

Vestin, Holme; Oparina, Nina Y.; Eloranta, Maija-Leena; Frodlund, Martina et al.

Part of RMD Open, 2025

B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus

Hedenstedt, Anna; Reid, Sarah; Sayadi, Ahmed; Eloranta, Maija-Leena et al.

Part of Lupus Science and Medicine, 2023

2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice

Rodriguez-Carrio, Javier; Burska, Agata; Conaghan, Philip G.; Dik, Willem A. et al.

Part of Annals of the Rheumatic Diseases, p. 754-762, 2023

DOI for 2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice

Identification and Functional Characterization of a Novel Susceptibility Locus for Small Vessel Vasculitis with MPO-ANCA

Dahlqvist, Johanna; Ekman, Diana; Sennblad, Bengt; Kozyrev, Sergey V. et al.

Part of Rheumatology, p. 3461-3470, 2022

Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome

Lundtoft, Christian; Sjöwall, Christopher; Rantapää‐Dahlqvist, Solbritt; Bengtsson, Anders A. et al.

Part of Arthritis & Rheumatology, p. 1842-1850, 2022

Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases

Lundtoft, Christian; Pucholt, Pascal; Martin, Myriam; Bianchi, Matteo et al.

Part of Arthritis & Rheumatology, p. 1440-1450, 2022

Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease

Yavuz, Sule; Pucholt, Pascal; Sandling, Johanna K.; Bianchi, Matteo et al.

Part of Lupus Science and Medicine, 2022

Genome-wide association study identifies Sjogren's risk loci with functional implications in immune and glandular cells

Khatri, Bhuwan; Tessneer, Kandice L.; Rasmussen, Astrid; Aghakhanian, Farhang et al.

Part of Nature Communications, 2022

Different chest HRCT scan protocols change the extent of ground glass opacities

Emilsson, Össur Ingi; Dessle, Angelica; Johansson, Henrik; Adeli, Shamisa et al.

Part of BMC Pulmonary Medicine, 2022

Contributions of de novo variants to systemic lupus erythematosus

Carlsson Almlöf, Jonas; Nystedt, Sara; Mechtidou, Aikaterini; Leonard, Dag et al.

Part of European Journal of Human Genetics, p. 184-193, 2021

DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome

Imgenberg-Kreuz, Juliana; Sandling, Johanna K.; Norheim, Katrine Braekke; Johnsen, Svein Joar Auglaend et al.

Part of Frontiers in Immunology, 2021

C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205

Enocsson, Helena; Gullstrand, Birgitta; Eloranta, Maija-Leena; Wetterö, Jonas et al.

Part of Frontiers in Immunology, 2021

Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing

Sandling, Johanna K.; Pucholt, Pascal; Hultin-Rosenberg, Lina; Farias, Fabiana H. G. et al.

Part of Annals of the Rheumatic Diseases, p. 109-117, 2021

Comparison of Surrogate Markers of the Type I Interferon Response and Their Ability to Mirror Disease Activity in Systemic Lupus Erythematosus

Enocsson, Helena; Wetterö, Jonas; Eloranta, Maija-Leena; Gullstrand, Birgitta et al.

Part of Frontiers in Immunology, 2021

High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

Reid, Sarah; Alexsson, Andrei; Frodlund, Martina; Morris, David et al.

Part of Annals of the Rheumatic Diseases, p. 363-369, 2020

Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero

Hedlund, Malin; Thorlacius, Gudny Ella; Ivanchenko, Margarita; Ottosson, Vijole et al.

Part of RMD Open, 2020

The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells

Hjorton, Karin; Hagberg, Niklas; Pucholt, Pascal; Eloranta, Maija-Leena et al.

Part of Arthritis Research & Therapy, 2020

Activation of plasmacytoid dendritic cells and B cells with two structurally different Toll-like receptor 7 agonists

Berggren, Olof; Pucholt, Pascal; Amcoff, Cane; Rönnblom, Lars et al.

Part of Scandinavian Journal of Immunology, 2020

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

Lundtoft, Christian; Pucholt, Pascal; Imgenberg-Kreuz, Juliana; Carlsson Almlöf, Jonas et al.

Part of PLOS Genetics, 2020

Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus

Almlöf, Jonas Carlsson; Nystedt, Sara; Leonard, Dag; Eloranta, Maija-Leena et al.

Part of Human Genetics, p. 141-150, 2019

A case of systemic lupus erythematosus with C1q deficiency, increased serum interferon-a levels and high serum interferogenic activity

Bolin, Karin; Eloranta, Maija-Leena; Kozyrev, Sergey V.; Dahlqvist, Johanna et al.

Part of Rheumatology, p. 918-919, 2019

DOI for A case of systemic lupus erythematosus with C1q deficiency, increased serum interferon-a levels and high serum interferogenic activity

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

Odqvist, Lina; Jevnikar, Zala; Riise, Rebecca; Oberg, Lisa et al.

Part of Annals of the Rheumatic Diseases, p. 1363-1370, 2019

A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts

Farias, Fabiana H. G.; Dahlqvist, Johanna; Kozyrev, Sergey V.; Leonard, Dag et al.

Part of European Journal of Human Genetics, p. 432-441, 2019

DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus

Imgenberg-Kreuz, Juliana; Almlöf, Jonas Carlsson; Leonard, Dag; Alexsson, Andrei et al.

Part of Annals of the Rheumatic Diseases, p. 736-743, 2018

Transcription profiling of peripheral B cells in antibody-positive primary Sjogren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature

Imgenberg-Kreuz, Juliana; Sandling, Johanna K.; Bjork, A.; Nordlund, J. et al.

Part of Scandinavian Journal of Immunology, 2018

T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus

Houtman, Miranda; Shchetynsky, Klementy; Chemin, Karine; Hensvold, Aase Haj et al.

Part of Journal of Autoimmunity, p. 28-38, 2018

Interleukin-22 and associated genes are targets of microRNAs dysregulated

Tarn, Jessica R.; Nordmark, Gunnel; Gillespie, Colin; Al-Ali, Shereen et al.

Part of Clinical and Experimental Rheumatology, 2018

Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis

Leonard, Dag; Svenungsson, Elisabet; Dahlqvist, Johanna; Alexsson, Andrei et al.

Part of Annals of the Rheumatic Diseases, p. 1063-1069, 2018

The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE

Hagberg, Niklas; Joelsson, Martin; Leonard, Dag; Reid, Sarah et al.

Part of Annals of the Rheumatic Diseases, p. 1070-1077, 2018

Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Hjorton, Karin; Hagberg, Niklas; Israelsson, Elisabeth; Jinton, Lisa et al.

Part of Arthritis Research & Therapy, 2018

The risk allele A of rs200395694 associated with SLE in Swedish patients affects on MEF2D gene regulation and alternative splicing

Abramov, Sergei; Kozyrev, Sergey V.; Farias, Fabiana H. G.; Dahlqvist, Johanna et al.

Part of Human Gene Therapy, 2018

ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease

Bremer, Hanna D.; Landegren, Nils; Sjöberg, Ronald; Hallgren, Åsa et al.

Part of Scientific Reports, 2018

Interferon-α coincides with suppressed levels of pentraxin-3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 in vitro

Wirestam, Lina; Enocsson, Helena; Skogh, Thomas; Eloranta, Maija-Leena et al.

Part of Clinical and Experimental Immunology, p. 83-91, 2017

DOI for Interferon-α coincides with suppressed levels of pentraxin-3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 in vitro

Novel risk genes for systemic lupus erythematosus predicted by random forest classification

Carlsson Almlöf, Jonas; Alexsson, Andrei; Imgenberg-Kreuz, Juliana; Sylwan, Lina et al.

Part of Scientific Reports, 2017

Type I IFN System Activation In Newborns Exposed To ANTI-RO/SSA Autoantibodies In Utero

Wahren, M.; Hedlund, M.; Thorlacius, G. E.; Ivanchenko, M. et al.

Part of Annals of the Rheumatic Diseases, p. 182-182, 2017

DOI for Type I IFN System Activation In Newborns Exposed To ANTI-RO/SSA Autoantibodies In Utero

High Genetic Risk Score Is Associated with Increased Organ Damage in SLE

Reid, Sarah; Alexsson, Andrei; Frodlund, Martina; Sandling, Johanna K. et al.

Part of Arthritis & Rheumatology, 2017

Type I IFN System Activation In Newborns Exposed To Anti-Ro/Ssa Autoantibodies In Utero

Hedlund, Malin; Thorlacius, Gudny Ella; Ivanchenko, Margarita; Kyriakidis, Nikolaos et al.

Part of Annals of the Rheumatic Diseases, 2017

DOI for Type I IFN System Activation In Newborns Exposed To Anti-Ro/Ssa Autoantibodies In Utero

Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus

Imgenberg-Kreuz, Juliana; Almlöf, Jonas Carlsson; Leonard, Dag; Nordmark, Gunnel et al.

Part of Arthritis & Rheumatology, 2017

Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero

Thorlacius, Gudny Ella; Hedlund, Malin; Ivanchenko, Margarita; Ottosson, Vijole et al.

Part of Arthritis & Rheumatology, 2017

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

Li, He; Reksten, Tove Ragna; Ice, John A.; Kelly, Jennifer A. et al.

Part of PLOS Genetics, 2017

Plasmacytoid dendritic cells and RNA-containing immune complexes drive expansion of peripheral B cell subsets with an SLE-like phenotype

Berggren, Olof; Hagberg, Niklas; Alexsson, Andrei; Weber, Gert et al.

Part of PLOS ONE, 2017

Activated Plasmacytoid Dendritic Cells (PDCS) Alter The Composition of The Blood B Cell Subsets

Berggren, Olof; Rönnblom, Lars; Eloranta, Maija-Leena

Part of Annals of the Rheumatic Diseases, p. 179-179, 2016

DOI for Activated Plasmacytoid Dendritic Cells (PDCS) Alter The Composition of The Blood B Cell Subsets

The Effect of Hydroxychloroquine and IRAK4 Inhibition on The IFN-A and TNF-A Production Induced by Sle Related Immune Complexes

Hjorton, Karin; Hagberg, Niklas; Berggren, Olof; Mo, J. et al.

Part of Annals of the Rheumatic Diseases, p. 277-277, 2016

DOI for The Effect of Hydroxychloroquine and IRAK4 Inhibition on The IFN-A and TNF-A Production Induced by Sle Related Immune Complexes

The effect of PTPN22 Gene Variant R620W on the Type I Interferon Production Stimulated by Different TLR7 Agonists: Comment on Article by Wang et al (pages 2403-2414)

Berggren, Olof; Rönnblom, Lars; Eloranta, Maija-Leena

Part of Arthritis & Rheumatology, p. 1045-1045, 2016

DOI for The effect of PTPN22 Gene Variant R620W on the Type I Interferon Production Stimulated by Different TLR7 Agonists: Comment on Article by Wang et al (pages 2403-2414)

Cause and consequences of the activated type I interferon system in SLE

Eloranta, Maija-Leena; Rönnblom, Lars

Part of Journal of Molecular Medicine, p. 1103-1110, 2016

Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes

Leonard, Dag; Eloranta, Maija-Leena; Hagberg, Niklas; Berggren, Olof et al.

Part of Annals of the Rheumatic Diseases, p. 1728-1734, 2016

DOI for Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes

Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes

Imgenberg-Kreuz, Juliana; Sandling, Johanna K.; Almlöf, Jonas Carlsson; Nordlund, Jessica et al.

Part of Annals of the Rheumatic Diseases, p. 2029-2036, 2016

Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study.

Folkersen, Lasse; Brynedal, Boel; Diaz-Gallo, Lina Marcela; Ramsköld, Daniel et al.

Part of Molecular Medicine, p. 322-328, 2016

Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression

Cavalli, Marco; Pan, Gang; Nord, Helena; Wallerman, Ola et al.

Part of Human Genetics, p. 485-497, 2016

Functional Anti-CD94/NKG2A and Anti-CD94/NKG2C Autoantibodies in Patients With Systemic Lupus Erythematosus

Hagberg, Niklas; Theorell, Jakob; Hjorton, Karin; Spee, Pieter et al.

Part of ARTHRITIS & RHEUMATOLOGY, p. 1000-1011, 2015

DOI for Functional Anti-CD94/NKG2A and Anti-CD94/NKG2C Autoantibodies in Patients With Systemic Lupus Erythematosus

Genome-Wide Analysis of DNA Methylation Profiles in Multiple Tissues in Primary Sjogren's Syndrome

Imgenberg-Kreuz, Juliana; Sandling, Johanna K.; Carlsson Almlöf, Jonas; Omdal, Roald et al.

Part of Scandinavian Journal of Immunology, p. 412-412, 2015

Identification of Novel Sjogren's Syndrome Risk Loci in the Regions of TNFAIP3 and PRDM1

Lessard, Christopher J.; Li, He; Ice, John; Adrianto, Indra et al.

Part of Arthritis & Rheumatology, 2015

DOI for Identification of Novel Sjogren's Syndrome Risk Loci in the Regions of TNFAIP3 and PRDM1

Hypomethylation in Enhancer and Promoter Regions of Interferon Regulated Genes in Multiple Tissues Is Associated with Primary Sjogren's Syndrome

Imgenberg-Kreuz, Juliana; Sandling, Johanna K.; Almlöf, Jonas Carlsson; Nordlund, Jessica et al.

Part of Arthritis & Rheumatology, 2015

DOI for Hypomethylation in Enhancer and Promoter Regions of Interferon Regulated Genes in Multiple Tissues Is Associated with Primary Sjogren's Syndrome

Genome-wide analysis of DNA methylation in systemic lupus erythematosus

Sandling, Johanna K.; Imgenberg-Kreuz, Juliana; Carlsson Almlöf, Jonas; Nordmark, Gunnel et al.

Part of Clinical and Experimental Rheumatology, 2015

IFN-α production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases

Berggren, Olof; Alexsson, Andrei; Morris, David; Tandre, Karolina et al.

Part of Human Molecular Genetics, p. 3571-3581, 2015

DOI for IFN-α production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases

An NFKB1 gene promoter polymorphism is associated with primary Sjogren's syndrome

Nordmark, Gunnel; Vasaitis, Lilian; Theander, E.; Kvarnstrom, M. et al.

Part of Scandinavian Journal of Rheumatology, p. 87-88, 2014

High-Throughput Sequencing of 219 Candidate Genes for Identification of SLE-Associated Risk Variants

Farias, Fabiana; Wilbe, Maria; Dahlqvist, Johanna; Leonard, Dag et al.

Part of Arthritis & Rheumatology, 2014

Effect of single-nucleotide polymorphisms on type I interferon production by plasmacytoid dendritic cells stimulated with SLE-associated immune complexes

Berggren, Olof; Alexsson, Andrei; Tandre, Karolina; Syvanen, A-C et al.

Part of Scandinavian Journal of Rheumatology, p. 92-92, 2014

Activated T cells enhance interferon-alpha production by plasmacytoid dendritic cells stimulated by RNA-containing immune complexes

Leonard, Dag; Eloranta, Maija-Leena; Hagberg, Niklas; Berggren, Olof et al.

Part of Scandinavian Journal of Rheumatology, p. 88-89, 2014

Genome-Wide DNA Methylation Analysis of CD19+B Cells in Primary Sjogren's Syndrome

Nordmark, Gunnel; Imgenberg-Kreuz, Juliana; Almlöf, Jonas Carlsson; Nordlund, Jessica et al.

Part of Arthritis & Rheumatology, 2014

Activated SLE-T Cells Enhance the Interferon-Alpha Production By Plasmacytoid Dendritic Cells Stimulated By RNA-IC

Leonard, Dag; Eloranta, Maija-Leena; Hagberg, Niklas; Berggren, Olof et al.

Part of Arthritis & Rheumatology, 2014

Serum C-reactive protein (CRP) associates with lupus disease activity in the absence of measurable interferon alpha and a CRP gene variant

Enocsson, Helena; Sjöwall, Christopher; Kastbom, Alf; Skogh, Thomas et al.

Part of Arthritis & rheumatology, p. 1568-1573, 2014

DOI for Serum C-reactive protein (CRP) associates with lupus disease activity in the absence of measurable interferon alpha and a CRP gene variant

Brief Report: Interferon-α Induction and Detection of Anti-Ro, Anti-La, Anti-Sm, and Anti-RNP Autoantibodies by Autoantigen Microarray Analysis in Juvenile Dermatomyositis

Balboni, Imelda; Niewold, Timothy B; Morgan, Gabrielle; Limb, Cindy et al.

Part of Arthritis and Rheumatism, p. 2424-2429, 2013

DOI for Brief Report: Interferon-α Induction and Detection of Anti-Ro, Anti-La, Anti-Sm, and Anti-RNP Autoantibodies by Autoantigen Microarray Analysis in Juvenile Dermatomyositis

Dual role of CpG-stimulated B cells in the regulation of dendritic cells: comment on the article by Berggren et al Reply

Eloranta, Maija-Leena; Rönnblom, Lars

Part of Arthritis and Rheumatism, p. 2216, 2013

DOI for Dual role of CpG-stimulated B cells in the regulation of dendritic cells: comment on the article by Berggren et al Reply

Two rare disease-associated tyk2 variants are catalytically impaired but signaling competent

Li, Zhi; Gakovic, Milica; Ragimbeau, Josiane; Eloranta, Maija-Leena et al.

Part of Journal of Immunology, p. 2335-2344, 2013

DOI for Two rare disease-associated tyk2 variants are catalytically impaired but signaling competent

Disease Mechanisms in RheumatologyTools and Pathways: Plasmacytoid Dendritic Cells and Their Role in AutoimmuneRheumatic Diseases

Eloranta, Maija-Leena; Alm, Gunnar V; Rönnblom, Lars

Part of Arthritis and Rheumatism, p. 853-863, 2013

DOI for Disease Mechanisms in RheumatologyTools and Pathways: Plasmacytoid Dendritic Cells and Their Role in AutoimmuneRheumatic Diseases

Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus

Hagberg, Niklas; Theorell, Jakob; Eloranta, Maija-Leena; Pascal, Veronique et al.

Part of Rheumatology, p. 1818-1823, 2013

DOI for Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus

NCR3/NKp30 Contributes to Pathogenesis in Primary Sjögren's Syndrome

Rusakiewicz, Sylvie; Nocturne, Gaetane; Lazure, Thierry; Semeraro, Michaela et al.

Part of Science Translational Medicine, 2013

DOI for NCR3/NKp30 Contributes to Pathogenesis in Primary Sjögren's Syndrome

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

Lessard, Christopher J; Li, He; Adrianto, Indra; Ice, John A et al.

Part of Nature Genetics, p. 1284-1292, 2013

DOI for Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

RNA-Seq for Enrichment and Analysis of IRF5 Transcript Expression in SLE

Stone, R. C.; Du, P.; Feng, D.; Dhawan, K. et al.

Part of PLOS ONE, p. 54487, 2013

Association of genes in the NF-κB pathway with antibody positive primary Sjögren's syndrome

Nordmark, Gunnel; Wang, Chuan; Vasaitis, Lilian; Eriksson, Per et al.

Part of Scandinavian Journal of Immunology, p. 447-454, 2013

DOI for Association of genes in the NF-κB pathway with antibody positive primary Sjögren's syndrome

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Nordlund, Jessica; Bäcklin, Christofer L; Wahlberg, Per; Busche, Stephan et al.

Part of Genome Biology, 2013

DOI for Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility

Wang, Chuan; Ahlford, Annika; Laxman, Navya; Nordmark, Gunnel et al.

Part of Genes and Immunity, p. 217-222, 2013

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

Wang, Chuan; Ahlford, Annika; Järvinen, Tiina M; Nordmark, Gunnel et al.

Part of European Journal of Human Genetics, p. 994-999, 2013

DOI for Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis

Bolin, Karin; Sandling, Johanna K; Zickert, Agneta; Jönsen, Andreas et al.

Part of PLOS ONE, 2013

Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4

Wang, Chuan; Sandling, Johanna K; Hagberg, Niklas; Berggren, Olof et al.

Part of Annals of the Rheumatic Diseases, p. 96-103, 2013

DOI for Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4

The NKp30/B7H6 Axis Contributes To Pathogenesis In Primary Sjogren's Syndrome.

Nocturne, Gaetane; Rusakiewicz, Sylvie; Sene, Damien; Nordmark, Gunnel et al.

Part of Arthritis and Rheumatism, 2013

Systemic Lupus Erythematosus Immune Complexes Increase the Expression of SLAM Family Members CD319 (CRACC) and CD229 (LY-9) on Plasmacytoid Dendritic Cells and CD319 on CD56(dim) NK Cells

Hagberg, Niklas; Theorell, Jakob; Schlums, Heinrich; Eloranta, Maija-Leena et al.

Part of Journal of Immunology, p. 2989-2998, 2013

DOI for Systemic Lupus Erythematosus Immune Complexes Increase the Expression of SLAM Family Members CD319 (CRACC) and CD229 (LY-9) on Plasmacytoid Dendritic Cells and CD319 on CD56(dim) NK Cells

Coronary heart disease in systemic lupus erythematosus is associated with interferon regulatory factor-8 gene variants

Leonard, Dag; Svenungsson, Elisabet; Sandling, Johanna K; Berggren, Olof et al.

Part of Circulation, p. 255-263, 2013

DOI for Coronary heart disease in systemic lupus erythematosus is associated with interferon regulatory factor-8 gene variants

On the Origin of the Type I Interferon Activity in Rheumatoid Arthritis

de Jong, T. D.; Vosslamber, S.; Eloranta, Maija-Leena; Rönnblom, Lars et al.

Part of Annals of the Rheumatic Diseases, 2013

DOI for On the Origin of the Type I Interferon Activity in Rheumatoid Arthritis

Coronary Heart Disease in Systemic Lupus Erythematosus is Associated with Interferon Regulatory Factor 8 Gene Variants

Leonard, Dag; Svenungsson, E.; Sandling, J. K.; Berggren, Olof et al.

Part of Annals of the Rheumatic Diseases, p. 270-270, 2013

DOI for Coronary Heart Disease in Systemic Lupus Erythematosus is Associated with Interferon Regulatory Factor 8 Gene Variants

SLE immune complexes upregulate the expression of slamf7 (cd319) on plasmacytoid dendritic cells

Hagberg, Niklas; Theorell, Jakob; Alm, Gunnar V.; Eloranta, Maija-Leena et al.

Part of Annals of the Rheumatic Diseases, 2012

DOI for SLE immune complexes upregulate the expression of slamf7 (cd319) on plasmacytoid dendritic cells

Autoantibodies associated with RNA are more enriched than anti-dsDNA antibodies in circulating immune complexes in SLE

Åhlin, Erik; Mathsson, Linda; Eloranta, Maija-Leena; Jonsdottir, Thorunn et al.

Part of Lupus, p. 586-595, 2012

DOI for Autoantibodies associated with RNA are more enriched than anti-dsDNA antibodies in circulating immune complexes in SLE

Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons

Stone, Rivka C; Feng, Di; Deng, Jing; Singh, Sukhwinder et al.

Part of Arthritis and Rheumatism, p. 788-798, 2012

DOI for Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons

B lymphocytes enhance the interferon-α production by plasmacytoid dendritic cells

Berggren, Olof; Hagberg, Niklas; Weber, Gert; Alm, Gunnar V et al.

Part of Arthritis and Rheumatism, p. 3409-3419, 2012

DOI for B lymphocytes enhance the interferon-α production by plasmacytoid dendritic cells

On the Origin of the Type I Interferon Signature in Rheumatoid Arthritis

de Jong, T. D.; Vosslamber, Saskia; Eloranta, Maija-Leena; Rönnblom, Lars et al.

Part of Arthritis and Rheumatism, 2012

Systemic Lupus Erythematosus Immune Complexes Upregulate the Expression of CD319 and CD229 On Plasmacytoid Dendritic Cells

Hagberg, Niklas; Theorell, Jakob; Alm, Gunnar V.; Eloranta, Maija-Leena et al.

Part of Arthritis and Rheumatism, 2012

Genetic Variation in the NCR3 Locus Is Associated with Anti-SSA/SSB Positive Primary Sjogren's Syndrome in Scandinavian Samples

Nordmark, Gunnel; Eloranta, Maija-Leena; Eriksson, Per; Theander, Elke et al.

Part of Arthritis and Rheumatism, 2012

Variation of Interferon-Alpha Production in Healthy Individuals and Association with Autoimmune Susceptibility Genes

Berggren, Olof; Alexsson, Andrei; Alm, Gunnar V.; Syvanen, Ann-Christine et al.

Part of Arthritis and Rheumatism, 2012

IFN-α Production by Plasmacytoid Dendritic Cells Stimulated with RNA-Containing Immune Complexes Is Promoted by NK Cells via MIP-1β and LFA-1

Hagberg, Niklas; Berggren, Olof; Leonard, Dag; Weber, Gert et al.

Part of Journal of Immunology, p. 5085-5094, 2011

DOI for IFN-α Production by Plasmacytoid Dendritic Cells Stimulated with RNA-Containing Immune Complexes Is Promoted by NK Cells via MIP-1β and LFA-1

Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus

Jonsen, Andreas; Nilsson, Sara C; Ahlqvist, Emma; Svenungsson, Elisabet et al.

Part of Arthritis Research & Therapy, 2011

Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome

Nordmark, Gunnel; Kristjansdottir, Gudlaug; Theander, E.; Appel, S. et al.

Part of Genes and Immunity, p. 100-109, 2011

DOI for Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

Sandling, Johanna K.; Garnier, Sophie; Sigurdsson, Snaevar; Wang, Chuan et al.

Part of European Journal of Human Genetics, p. 479-484, 2011

DOI for A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

Effects of high mobility group box protein-1, interleukin-1β, and interleukin-6 on cartilage matrix metabolism in three-dimensional equine chondrocyte cultures

Ley, Cecilia; Svala, Emilia; Nilton, Anna; Lindahl, Anders et al.

Part of Connective Tissue Research, p. 290-300, 2011

DOI for Effects of high mobility group box protein-1, interleukin-1β, and interleukin-6 on cartilage matrix metabolism in three-dimensional equine chondrocyte cultures

Type I interferon system activation and association with disease manifestations in systemic sclerosis

Eloranta, Maija-Leena; Franck-Larsson, Karin; Lövgren, Tanja; Kalamajski, Sebastian et al.

Part of Annals of the Rheumatic Diseases, p. 1396-1402, 2010

DOI for Type I interferon system activation and association with disease manifestations in systemic sclerosis

Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus

Feng, Di; Stone, Rivka C.; Eloranta, Maija-Leena; Sangster-Guity, Niquiche et al.

Part of Arthritis and Rheumatism, p. 562-573, 2010

DOI for Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus

C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis

Lood, Christian; Gullstrand, Birgitta; Truedsson, Lennart; Olin, Anders I. et al.

Part of Arthritis and Rheumatism, p. 3081-3090, 2009

DOI for C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis

Interferon-alpha Mediates Suppression of C-Reactive Protein Explanation for Muted C-Reactive Protein Response in Lupus Flares?

Enocsson, Helena; Sjöwall, Christopher; Skogh, Thomas; Eloranta, Maija-Leena et al.

Part of Arthritis and Rheumatism, p. 3755-3760, 2009

DOI for Interferon-alpha Mediates Suppression of C-Reactive Protein Explanation for Muted C-Reactive Protein Response in Lupus Flares?

Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE

Isaksson, Magnus; Ardesjö, Brita; Rönnblom, Lars; Kämpe, Olle et al.

Part of European Journal of Immunology, p. 2925-2935, 2009

DOI for Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE

Interleukin-6 and high mobility group box protein-1 in synovial membranes and osteochondral fragments in equine osteoarthritis

Ley, Cecilia; Ekman, S.; Ronéus, B.; Eloranta, Maija-Leena

Part of Research in Veterinary Science, p. 490-497, 2009

DOI for Interleukin-6 and high mobility group box protein-1 in synovial membranes and osteochondral fragments in equine osteoarthritis

Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells

Eloranta, Maija-Leena; Lövgren, Tanja; Finke, Doreen; Mathsson, Linda et al.

Part of Arthritis and Rheumatism, p. 2418-2427, 2009

DOI for Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells

Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome

Nordmark, Gunnel; Kristjansdottir, Gudlaug; Theander, E.; Eriksson, P. et al.

Part of Genes and Immunity, p. 68-76, 2009

DOI for Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome

Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus

Schepis, Danika; Gunnarsson, Iva; Eloranta, Maija-Leena; Lampa, Jon et al.

Part of Immunology, p. 140-6, 2009

DOI for Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway

Espinosa, Alexander; Dardalhon, Valerie; Brauner, Susanna; Ambrosi, Aurelie et al.

Part of Journal of Experimental Medicine, p. 1661-1671, 2009

DOI for Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway

Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus

Sigurdsson, Snaevar; Göring, Harald H. H.; Kristjansdottir, Gudlaug; Milani, Lili et al.

Part of Human Molecular Genetics, p. 872-881, 2008

DOI for Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

Sigurdsson, Snaevar; Nordmark, Gunnel; Garnier, Sophie; Grundberg, Elin et al.

Part of Human Molecular Genetics, p. 2868-2876, 2008

DOI for A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies

Strandberg, Linn; Ambrosi, Aurelie; Espinosa, Alexander; Ottosson, Lars et al.

Part of Journal of Clinical Immunology, p. 220-31, 2008

DOI for Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies

A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies

Eloranta, Maija-Leena; Helmers, Sevim Barbasso; Ulfgren, Ann-Kristin; Rönnblom, Lars et al.

Part of Arthritis and Rheumatism, p. 3112-3124, 2007

DOI for A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies

Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology

Ley, Cecilia; Ekman, S.; Elmén, A.; Nilsson, G. et al.

Part of Journal of Veterinary Medicine A, p. 346-351, 2007

DOI for Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology

Induction of interferon-α by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA

Lövgren, Tanja; Eloranta, Maija-Leena; Kastner, Berthold; Wahren-Herlenius, Marie et al.

Part of Arthritis and Rheumatism, p. 1917-1927, 2006

DOI for Induction of interferon-α by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA

Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism

Båve, Ullvi; Nordmark, Gunnel; Lövgren, Tanja; Rönnelid, Johan et al.

Part of Arthritis and Rheumatism, p. 1185-1195, 2005

DOI for Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism

Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus

Sigurdsson, Snaevar; Nordmark, Gunnel; Göring, Harald; Lindroos, Katarina et al.

Part of American Journal of Human Genetics, p. 528-537, 2005

DOI for Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus

Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage

Gruic, Mirjana; Braga, Tiago; Lukinius, Agneta; Eloranta, Maija-Leena et al.

Part of Journal of Biological Chemistry, p. 33411-33418, 2005

DOI for Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage

Induction of interferon-α production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG

Lövgren, Tanja; Eloranta, Maija-Leena; Båve, Ullvi; Alm, Gunnar V. et al.

Part of Arthritis and Rheumatism, p. 1861-1872, 2004

DOI for Induction of interferon-α production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG

Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG

Båve, Ullvi; Magnuson, Mattias; Eloranta, Maija-Leena; Perers, Anders et al.

Part of Journal of Immunology, p. 3296-302, 2003

Effects of coxsackievirus B3 infection on the acute-phase protein metallothionein and on cytochrome P-4501A1 involved in the detoxification processes of TCDD in the mouse

Funseth, Eva; Påhlman, Martin; Eloranta, Maija-Leena; Friman, Gunnar et al.

Part of Science of the Total Environment, p. 37-47, 2002

DOI for Effects of coxsackievirus B3 infection on the acute-phase protein metallothionein and on cytochrome P-4501A1 involved in the detoxification processes of TCDD in the mouse

Presence of cutaneous interferon-alpha producing cells in patients with systemic lupus erythematosus

Blomberg, Stina; Eloranta, Maija-Leena; Cederblad, Brita; Nordlin, K et al.

Part of Lupus, p. 484-90, 2001

DOI for Presence of cutaneous interferon-alpha producing cells in patients with systemic lupus erythematosus

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