Måns Ehrenberg

The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

Fu, Ziao; Indrisiunaite, Gabriele; Kaledhonkar, Sandip; Shah, Binita et al.

Part of Novel Developments in Cryo EM of Biological Molecules, p. 481-500, Jenny Stanford Publishing, 2023

• DOI for The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

Dynamics of release factor recycling during translation termination in bacteria

Prabhakar, Arjun; Pavlov, Michael Y.; Zhang, Jingji; Indrisiunaite, Gabriele et al.

Part of Nucleic Acids Research, p. 5774-5790, 2023

• DOI for Dynamics of release factor recycling during translation termination in bacteria
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Uncovering translation roadblocks during the development of a synthetic tRNA

Prabhakar, Arjun; Krahn, Natalie; Zhang, Jingji; Vargas-Rodriguez, Oscar et al.

Part of Nucleic Acids Research, p. 10201-10211, 2022

• DOI for Uncovering translation roadblocks during the development of a synthetic tRNA
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N-6-Methyladenosines in mRNAs reduce the accuracy of codon reading by transfer RNAs and peptide release factors

Ieong, Ka-Weng; Indrisiunaite, Gabriele; Prabhakar, Arjun; Puglisi, Joseph D. et al.

Part of Nucleic Acids Research, p. 2684-2699, 2021

• DOI for N-6-Methyladenosines in mRNAs reduce the accuracy of codon reading by transfer RNAs and peptide release factors
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Estimation of peptide elongation times from ribosome profiling spectra

Pavlov, Michael; Ullman, Gustaf; Ignatova, Zoya; Ehrenberg, Måns

Part of Nucleic Acids Research, p. 5124-5142, 2021

• DOI for Estimation of peptide elongation times from ribosome profiling spectra
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Dynamics of release factor recycling during translation termination in bacteria

Prabhakar, Arjun; Pavlov, Michael Y.; Zhang, Jingji; Indrisiunaite, Gabriele et al.

Part of Nucleic Acids Research, p. 5774-5790, 2023

• DOI for Dynamics of release factor recycling during translation termination in bacteria
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Uncovering translation roadblocks during the development of a synthetic tRNA

Prabhakar, Arjun; Krahn, Natalie; Zhang, Jingji; Vargas-Rodriguez, Oscar et al.

Part of Nucleic Acids Research, p. 10201-10211, 2022

• DOI for Uncovering translation roadblocks during the development of a synthetic tRNA
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N-6-Methyladenosines in mRNAs reduce the accuracy of codon reading by transfer RNAs and peptide release factors

Ieong, Ka-Weng; Indrisiunaite, Gabriele; Prabhakar, Arjun; Puglisi, Joseph D. et al.

Part of Nucleic Acids Research, p. 2684-2699, 2021

• DOI for N-6-Methyladenosines in mRNAs reduce the accuracy of codon reading by transfer RNAs and peptide release factors
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Estimation of peptide elongation times from ribosome profiling spectra

Pavlov, Michael; Ullman, Gustaf; Ignatova, Zoya; Ehrenberg, Måns

Part of Nucleic Acids Research, p. 5124-5142, 2021

• DOI for Estimation of peptide elongation times from ribosome profiling spectra
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The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation

Holm, Mikael; Mandava, Chandra Sekhar; Ehrenberg, Måns; Sanyal, Suparna

Part of eLIFE, 2019

• DOI for The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation
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The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

Fu, Ziao; Indrisiunaite, Gabriele; Kaledhonkar, Sandip; Shah, Binita et al.

Part of Nature Communications, 2019

• DOI for The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy
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Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor

Zukher, Inna; Pavlov, Michael; Tsibulskaya, Darya; Kulikovsky, Alexey et al.

Part of mBio, 2019

• DOI for Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor
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Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg2+ ions

Zhang, Jingji; Pavlov, Michael; Ehrenberg, Måns

Part of Nucleic Acids Research, p. 1362-1374, 2018

• DOI for Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg2+ ions
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2'-O-methylation in mRNA disrupts tRNA decoding during translation elongation

Choi, Junhong; Indrisiunaite, Gabriele; DeMirci, Hasan; Leong, Ka-Weng et al.

Part of Nature Structural & Molecular Biology, p. 208-216, 2018

• DOI for 2'-O-methylation in mRNA disrupts tRNA decoding during translation elongation

Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-Tu(H84A)

Fislage, Marcus; Zhang, Jingji; Brown, Zuben Patrick; Mandava, Chandra Sekhar et al.

Part of Nucleic Acids Research, p. 5861-5874, 2018

• DOI for Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-Tu(H84A)
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The Structural Basis for Initiation Factor 2 Activation during Translation Initiation

Caban, Kelvin; Pavlov, Michael; Kaledhonkar, Sandip; Fu, Ziao et al.

Part of Biophysical Journal, 2018

How 2 '-O-Methylation in mRNA Disrupts tRNA Decoding during Translation Elongation

Choi, Junhong; Indrisiunaite, Gabriele; DeMirci, Hasan; Ieong, Ka-Weng et al.

Part of Biophysical Journal, 2018

Transcriptional accuracy modeling suggests two-step proofreading by RNA polymerase

Mellenius, Harriet; Ehrenberg, Måns

Part of Nucleic Acids Research, p. 11582-11593, 2017

• DOI for Transcriptional accuracy modeling suggests two-step proofreading by RNA polymerase
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A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria

Caban, Kelvin; Pavlov, Michael; Ehrenberg, Måns; Gonzalez, Ruben L.

Part of Nature Communications, 2017

• DOI for A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
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Ribosomes are optimized for autocatalytic production

Reuveni, Shlomi; Ehrenberg, Måns; Paulsson, Johan

Part of Nature, p. 293-297, 2017

• DOI for Ribosomes are optimized for autocatalytic production

Two proofreading steps amplify the accuracy of genetic code translation

Ieong, Ka-Weng; Uzun, Ülkü; Selmer, Maria; Ehrenberg, Måns

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 13744-13749, 2016

• DOI for Two proofreading steps amplify the accuracy of genetic code translation

Complete kinetic mechanism for recycling of the bacterial ribosome

Borg, Anneli; Pavlov, Michael; Ehrenberg, Måns

Part of RNA, p. 10-21, 2016

• DOI for Complete kinetic mechanism for recycling of the bacterial ribosome

Key Intermediates in Ribosome Recycling Visualized by Time-Resolved Cryoelectron Microscopy

Fu, Ziao; Kaledhonkar, Sandip; Borg, Anneli; Sun, Ming et al.

Part of Structure, p. 2092-2101, 2016

• DOI for Key Intermediates in Ribosome Recycling Visualized by Time-Resolved Cryoelectron Microscopy

N-6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

Choi, Junhong; Ieong, Ka-Weng; Demirci, Hasan; Chen, Jin et al.

Part of Nature Structural & Molecular Biology, p. 110-+, 2016

• DOI for N-6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

Mechanism of fusidic acid inhibition of RRF- and EF-G-dependent splitting of the bacterial post-termination ribosome

Borg, Anneli; Pavlov, Michael; Ehrenberg, Måns

Part of Nucleic Acids Research, p. 3264-3275, 2016

• DOI for Mechanism of fusidic acid inhibition of RRF- and EF-G-dependent splitting of the bacterial post-termination ribosome
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Proofreading neutralizes potential error hotspots in genetic code translation by transfer RNAs

Zhang, Jingji; Ieong, Ka-Weng; Mellenius, Harriet; Ehrenberg, Måns

Part of RNA, p. 896-904, 2016

• DOI for Proofreading neutralizes potential error hotspots in genetic code translation by transfer RNAs
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Molecular mechanism of viomycin inhibition of peptide elongation in bacteria

Holm, Mikael; Borg, Anneli; Ehrenberg, Måns; Sanyal, Suparna

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 978-983, 2016

• DOI for Molecular mechanism of viomycin inhibition of peptide elongation in bacteria

DNA Template Dependent Accuracy Variation of Nucleotide Selection in Transcription

Mellenius, Harriet; Ehrenberg, Måns

Part of PLOS ONE, 2015

• DOI for DNA Template Dependent Accuracy Variation of Nucleotide Selection in Transcription
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On the pH Dependence of Class-1 RF-Dependent Termination of mRNA Translation

Indrisiunaite, Gabriele; Pavlov, Michael Y.; Heurgue-Hamard, Valerie; Ehrenberg, Måns

Part of Journal of Molecular Biology, p. 1848-1860, 2015

• DOI for On the pH Dependence of Class-1 RF-Dependent Termination of mRNA Translation
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Fusidic Acid Targets Elongation Factor G in Several Stages of Translocation on the Bacterial Ribosome

Borg, Anneli; Holm, Mikael; Shiroyama, Ikue; Hauryliuk, Vasili et al.

Part of Journal of Biological Chemistry, p. 3440-3454, 2015

• DOI for Fusidic Acid Targets Elongation Factor G in Several Stages of Translocation on the Bacterial Ribosome

Determinants of the Rate of mRNA Translocation in Bacterial Protein Synthesis

Borg, Anneli; Ehrenberg, Måns

Part of Journal of Molecular Biology, p. 1835-1847, 2015

• DOI for Determinants of the Rate of mRNA Translocation in Bacterial Protein Synthesis
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Accuracy of initial codon selection by aminoacyl-tRNAs on the mRNA-programmed bacterial ribosome

Zhang, Jingji; Ieong, Ka-Weng; Johansson, Magnus; Ehrenberg, Måns

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 9602-9607, 2015

• DOI for Accuracy of initial codon selection by aminoacyl-tRNAs on the mRNA-programmed bacterial ribosome
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Free RNA polymerase in Escherichia coli

Patrick, Michael; Dennis, Patrick P.; Ehrenberg, Måns; Bremer, Hans

Part of Biochimie, p. 80-91, 2015

• DOI for Free RNA polymerase in Escherichia coli

Peptide Formation by N-Methyl Amino Acids in Translation Is Hastened by Higher pH and tRNA^Pro

Wang, Jinfan; Kwiatkowski, Marek; Pavlov, Michael Yu; Ehrenberg, Måns et al.

Part of ACS Chemical Biology, p. 1303-1311, 2014

• DOI for Peptide Formation by N-Methyl Amino Acids in Translation Is Hastened by Higher pH and tRNA^Pro

Thermodynamic Modeling of Variations in the Rate of RNA Chain Elongation of E-coli rrn Operons

Fange, David; Mellenius, Harriet; Dennis, Patrick P.; Ehrenberg, Måns

Part of Biophysical Journal, p. 55-64, 2014

• DOI for Thermodynamic Modeling of Variations in the Rate of RNA Chain Elongation of E-coli rrn Operons

A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids

Ieong, Ka-Weng; Pavlov, Michael Y.; Kwiatkowski, Marek; Ehrenberg, Måns et al.

Part of RNA, p. 632-643, 2014

• DOI for A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids
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The Impact of Aminoglycosides on the Dynamics of Translation Elongation

Tsai, Albert; Uemura, Sotaro; Johansson, Magnus; Puglisi, Elisabetta Viani et al.

Part of Cell Reports, p. 497-508, 2013

• DOI for The Impact of Aminoglycosides on the Dynamics of Translation Elongation

Optimal control of gene expression for fast proteome adaptation to environmental change

Pavlov, Michael Y.; Ehrenberg, Måns

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 20527-20532, 2013

• DOI for Optimal control of gene expression for fast proteome adaptation to environmental change

Optimal Strategy for Rapid Proteome Re-Arrangements in Bacterial Populations

Ehrenberg, Måns; Pavlov, Michael Yu

Part of Biophysical Journal, 2013

• DOI for Optimal Strategy for Rapid Proteome Re-Arrangements in Bacterial Populations

Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1

Pallesen, Jesper; Hashem, Yaser; Korkmaz, Gürkan; Koripella, Ravi Kiran et al.

Part of eLife, 2013

• DOI for Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1
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Genetic code translation displays a linear trade-off between efficiency and accuracy of tRNA selection

Johansson, Magnus; Zhang, Jingji; Ehrenberg, Måns

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 131-136, 2012

• DOI for Genetic code translation displays a linear trade-off between efficiency and accuracy of tRNA selection

Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

Shyp, Viktoriya; Tankov, Stoyan; Ermakov, Andrey; Kudrin, Pavel et al.

Part of EMBO Reports, p. 835-839, 2012

• DOI for Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

Inefficient delivery but fast peptide bond formation of unnatural l -aminoacyl-tRNAs in translation

Ieong, Ka-Weng; Pavlov, Michael Y.; Kwiatkowski, Marek; Forster, Anthony C. et al.

Part of Journal of the American Chemical Society, p. 17955-17962, 2012

• DOI for Inefficient delivery but fast peptide bond formation of unnatural l -aminoacyl-tRNAs in translation

Identification of enzyme inhibitory mechanisms from steady-state kinetics

Fange, David; Lovmar, Martin; Pavlov, Michael Y.; Ehrenberg, Måns

Part of Biochimie, p. 1623-1629, 2011

• DOI for Identification of enzyme inhibitory mechanisms from steady-state kinetics

Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits

Pavlov, Michael Y.; Zorzet, Anna; Andersson, Dan I.; Ehrenberg, Måns

Part of EMBO Journal, p. 289-301, 2011

• DOI for Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits

pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA

Johansson, Magnus; Ieong, Ka-Weng; Trobro, Stefan; Strazewski, Peter et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 79-84, 2011

• DOI for pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA

Comment on "The mechanism for activation of GTP hydrolysis on the ribosome"

Liljas, Anders; Ehrenberg, Måns; Åqvist, Johan

Part of Science, p. 37, 2011

• DOI for Comment on "The mechanism for activation of GTP hydrolysis on the ribosome"

Thermodynamic Characterization of ppGpp Binding to EF-G or 1F2 and of Initiator tRNA Binding to Free 1F2 in the Presence of GDP, GTP, or ppGpp

Mitkevich, Vladimir A.; Ermakov, Andrey; Kulikova, Alexandra A.; Tankov, Stoyan et al.

Part of Journal of Molecular Biology, p. 838-846, 2010

• DOI for Thermodynamic Characterization of ppGpp Binding to EF-G or 1F2 and of Initiator tRNA Binding to Free 1F2 in the Presence of GDP, GTP, or ppGpp

Protein synthesis: Translocation in slow motion

Ehrenberg, Måns

Part of Nature, p. 325-326, 2010

• DOI for Protein synthesis: Translocation in slow motion

tmRNA-SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes.

Cheng, Kimberley; Ivanova, Natalia; Scheres, Sjors H. W.; Pavlov, Michael Y. et al.

Part of Journal of Structural Biology, p. 342-348, 2010

• DOI for tmRNA-SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes.

Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance

Zorzet, Anna; Pavlov, Michael; Nilsson, Annika; Ehrenberg, Måns et al.

Part of Molecular Microbiology, p. 1299-1313, 2010

• DOI for Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance
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Maximum rrn promoter activity in Escherichia coli at saturating concentrations of free RNA polymerase

Ehrenberg, Måns; Dennis, P P; Bremer, H

Part of Biochimie, p. 12-20, 2010

• DOI for Maximum rrn promoter activity in Escherichia coli at saturating concentrations of free RNA polymerase

Ribosomes lacking protein S20 are defective in mRNA binding and subunit association

Tobin, Christina; Mandava, Chandra Sekhar; Ehrenberg, Måns; Andersson, Dan I et al.

Part of Journal of Molecular Biology, p. 767-776, 2010

• DOI for Ribosomes lacking protein S20 are defective in mRNA binding and subunit association

Erythromycin resistance by L4/L22 mutations and resistance masking by drug efflux pump deficiency

Lovmar, Martin; Nilsson, Karin; Lukk, Eliisa; Vimberg, Vladimir et al.

Part of EMBO Journal, p. 736-744, 2009

• DOI for Erythromycin resistance by L4/L22 mutations and resistance masking by drug efflux pump deficiency

Slow peptide bond formation by proline and other N-alkylamino acids in translation

Pavlov, Michael Y; Watts, Richard E; Tan, Zhongping; Cornish, Virginia W et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 50-54, 2009

• DOI for Slow peptide bond formation by proline and other N-alkylamino acids in translation

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

Villa, Elizabeth; Sengupta, Jayati; Trabuco, Leonardo G.; LeBarron, Jamie et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 1063-1068, 2009

• DOI for Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

Drug efflux pump deficiency and drug target resistance masking in growing bacteria

Fange, David; Nilsson, Karin; Tenson, Tanel; Ehrenberg, Måns

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 8215-8220, 2009

• DOI for Drug efflux pump deficiency and drug target resistance masking in growing bacteria

Cis-acting resistance peptides reveal dual ribosome inhibitory action of the macrolide josamycin

Lovmar, Martin; Vimberg, Vladimir; Lukk, Eliisa; Nilsson, Karin et al.

Part of Biochimie, p. 989-995, 2009

• DOI for Cis-acting resistance peptides reveal dual ribosome inhibitory action of the macrolide josamycin

Varying rate of RNA chain elongation during rrn transcription in Escherichia coli.

Dennis, P P; Ehrenberg, Måns; Fange, David; Bremer, H

Part of Journal of Bacteriology, p. 3740-3746, 2009

• DOI for Varying rate of RNA chain elongation during rrn transcription in Escherichia coli.

Thermodynamics of GTP and GDP Binding to Bacterial Initiation Factor 2 Suggests Two Types of Structural Transitions

Hauryliuk, Vasili; Mitkevich, A; Draycheva, Albena; Tankov, Stoyan et al.

Part of Journal of Molecular Biology, p. 621-626, 2009

• DOI for Thermodynamics of GTP and GDP Binding to Bacterial Initiation Factor 2 Suggests Two Types of Structural Transitions

The kinetics of ribosomal peptidyl transfer revisited

Johansson, Magnus; Bouakaz, Elli; Lovmar, Martin; Ehrenberg, Måns

Part of Molecular Cell, p. 589-598, 2008

• DOI for The kinetics of ribosomal peptidyl transfer revisited

The pretranslocation ribosome is targeted by GTP-bound EF-G in partially activated form.

Hauryliuk, Vasili; Mitkevich, Vladimir A; Eliseeva, Natalia A; Petrushanko, Irina Yu et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 15678-83, 2008

• DOI for The pretranslocation ribosome is targeted by GTP-bound EF-G in partially activated form.

Co-factor dependent conformational switching of GTPases

Hauryliuk, Vasili; Hansson, Sebastian; Ehrenberg, Måns

Part of Biophysical Journal, p. 1704-1715, 2008

• DOI for Co-factor dependent conformational switching of GTPases

Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting

Pavlov, Michael Y; Antoun, Ayman; Lovmar, Martin; Ehrenberg, Måns

Part of EMBO Journal, p. 1706-1717, 2008

• DOI for Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting

Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM

Li, Wen; Agirrezabala, Xabier; Lei, Jianlin; Bouakaz, Lamine et al.

Part of EMBO Journal, p. 3322-3331, 2008

• DOI for Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM

The bacterial toxin ReIE induces specific mRNA cleavage in the A site of the eukaryote ribosome

Andreev, Dmitri; Hauryliuk, Vasili; Terenin, Ilya; Dmitriev, Sergey et al.

Part of RNA, p. 233-239, 2008

• DOI for The bacterial toxin ReIE induces specific mRNA cleavage in the A site of the eukaryote ribosome

Specific interaction between EF-G and RRF and its implication for GTP-dependent ribosome splitting into subunits

Gao, Ning; Zavialov, Andrey V.; Ehrenberg, Måns; Frank, Joachim

Part of Journal of Molecular Biology, p. 1345-1358, 2007

• DOI for Specific interaction between EF-G and RRF and its implication for GTP-dependent ribosome splitting into subunits

Structure probing of tmRNA in distinct stages of trans-translation

Ivanova, Natalia; Lindell, Magnus; Pavlov, Michael; Holmberg Schiavone, Lovisa et al.

Part of RNA, p. 713-722, 2007

• DOI for Structure probing of tmRNA in distinct stages of trans-translation

RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors

Gao, Haixiao; Zhou, Zhihong; Rawat, Urmila; Huang, Chenhui et al.

Part of Cell, p. 929-941, 2007

• DOI for RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors

Bistable bacterial growth rate in response to antibiotics with low membrane permeability

Elf, Johan; Nilsson, Karin; Tenson, Tanel; Ehrenberg, Måns

Part of Physical Review Letters, 2006

• DOI for Bistable bacterial growth rate in response to antibiotics with low membrane permeability

How initiation factors tune the rate of initiation of protein synthesis in bacteria.

Antoun, Ayman; Pavlov, Michael Y; Lovmar, Martin; Ehrenberg, Måns

Part of EMBO Journal, p. 2539-50, 2006

• DOI for How initiation factors tune the rate of initiation of protein synthesis in bacteria.

Class-1 release factor eRF1 promotes GTP binding by class-2 release factor eRF3

Hauryliuk, Vasili; Zavialov, Andrey; Kisselev, Lev; Ehrenberg, Måns

Part of Biochimie, p. 747-757, 2006

• DOI for Class-1 release factor eRF1 promotes GTP binding by class-2 release factor eRF3

Trigger factor binding to ribosomes with nascent peptide chains of varying lengths and sequences

Raine, Amanda; Lovmar, Martin; Wikberg, Jarl; Ehrenberg, Måns

Part of Journal of Biological Chemistry, p. 28033-28038, 2006

• DOI for Trigger factor binding to ribosomes with nascent peptide chains of varying lengths and sequences

Rate, accuracy and cost of ribosomes in bacterial cells

Lovmar, Martin; Ehrenberg, Måns

Part of Biochimie, p. 951-961, 2006

• DOI for Rate, accuracy and cost of ribosomes in bacterial cells

How initiation factors maximize the accuracy of tRNA selection in initiation of bacterial protein synthesis

Antoun, Ayman; Pavlov, Michael Y.; Lovmar, Martin; Ehrenberg, Måns

Part of Molecular Cell, p. 183-193, 2006

• DOI for How initiation factors maximize the accuracy of tRNA selection in initiation of bacterial protein synthesis

The molecular mechanism of peptide-mediated erythromycin resistance.

Lovmar, Martin; Nilsson, Karin; Vimberg, Vladimir; Tenson, Tanel et al.

Part of J Biol Chem, p. 6742-50, 2006

Two-step selection of mRNAs in initiation of protein synthesis.

Hauryliuk, Vasili; Ehrenberg, Måns

Part of Mol Cell, p. 155-6, 2006

Interactions of the release factor RF1 with the ribosome as revealed by cryo-EM.

Rawat, Urmila; Gao, Haixiao; Zavialov, Andrey; Gursky, Richard et al.

Part of J Mol Biol, p. 1144-53, 2006

A time-resolved investigation of ribosomal subunit association

Hennelly, Scott; Antoun, Ayman; Ehrenberg, Måns; Gualerzi, Claudio et al.

Part of Journal of Molecular Biology, p. 1243-1258, 2005

• DOI for A time-resolved investigation of ribosomal subunit association

What makes ribosome-mediated transcriptional attenuation sensitive to amino

Elf, Johan; Ehrenberg, Måns

Part of PloS Computational Biology, 2005

Over expression of a tRNA(Leu) isoacceptor changes charging pattern of leucine tRNAs and reveals new codon reading.

Sörensen, Michael A; Elf, Johan; Bouakaz, Elli; Tenson, Tanel et al.

Part of J Mol Biol, p. 16-24, 2005

tmRNA-induced release of messenger RNA from stalled ribosomes.

Ivanova, Natalia; Pavlov, Michael Y; Ehrenberg, Måns

Part of J Mol Biol, p. 897-905, 2005

Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs.

Zavialov, Andrey V; Hauryliuk, Vasili V; Ehrenberg, Måns

Part of J Biol, p. 9, 2005

A Time-resolved Investigation of Ribosomal Subunit Association

Hennelly, Scott; Antoun, Ayman; Ehrenberg, Måns; Gualerzi, Claudio et al.

Part of Journal of Molecular Biology, p. 1243-1258, 2005

• DOI for A Time-resolved Investigation of Ribosomal Subunit Association

The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure.

Vestergaard, Bente; Sanyal, Suparna; Roessle, Manfred; Mora, Liliana et al.

Part of Mol Cell, p. 929-38, 2005

Selective charging of tRNA isoacceptors induced by amino-acid starvation.

Dittmar, Kimberly A; Sörensen, Michael A; Elf, Johan; Ehrenberg, Måns et al.

Part of EMBO Rep, p. 151-7, 2005

Ribosome bypassing at serine codons as a test of the model of selective transfer RNA charging.

Lindsley, Dale; Bonthuis, Paul; Gallant, Jonathan; Tofoleanu, Teodora et al.

Part of EMBO Rep, p. 147-50, 2005

Near-critical behavior of aminoacyl-tRNA pools in E. coli at rate-limiting supply of amino acids.

Elf, Johan; Ehrenberg, Måns

Part of Biophys J, p. 132-46, 2005

Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies.

Gao, Ning; Zavialov, Andrey V; Li, Wen; Sengupta, Jayati et al.

Part of Mol Cell, p. 663-74, 2005

Mapping the interaction of SmpB with ribosomes by footprinting of ribosomal RNA.

Ivanova, Natalia; Pavlov, Michael Y; Bouakaz, Elli; Ehrenberg, Måns et al.

Part of Nucleic Acids Res, p. 3529-39, 2005

The cryo-EM structure of a translation initiation complex from Escherichia coli.

Allen, Gregory S; Zavialov, Andrey; Gursky, Richard; Ehrenberg, Måns et al.

Part of Cell, p. 703-12, 2005

Splitting of the posttermination ribosome into subunits by the concerted action of RRF and EF-G.

Zavialov, Andrey V; Hauryliuk, Vasili V; Ehrenberg, Måns

Part of Mol Cell, p. 675-86, 2005

Ribosome formation from subunits studied by stopped-flow and Rayleigh light scattering

Antoun, Ayman; Pavlov, Michael; Tenson, Tanel; Ehrenberg, Måns

Part of Biol Procedure Online, 2004

Spontaneous separation of bi-stable biochemical systems into spatial domains of opposite phases

Elf, Johan; Ehrenberg, Måns

Part of Systems Biology, p. 230-236, 2004

Dynamics of EF-G interaction with the ribosome explored by classification of a heterogeneous cryo-EM dataset.

Gao, Haixiao; Valle, Mikel; Ehrenberg, Måns; Frank, Joachim

Part of J Struct Biol, p. 283-90, 2004

Simultaneous binding of trigger factor and signal recognition particle to the E. coli ribosome.

Raine, Amanda; Ivanova, Natalia; Wikberg, Jarl E S; Ehrenberg, Måns

Part of Biochimie, p. 495-500, 2004

Kinetics of macrolide action: the josamycin and erythromycin cases.

Lovmar, Martin; Tenson, Tanel; Ehrenberg, Måns

Part of J Biol Chem, p. 53506-15, 2004

Termination of translation: interplay of mRNA, rRNAs and release factors?

Kisselev, L; Ehrenberg, M; Frolova, L

Part of EMBO J., p. 175-182, 2003

Selective loss of charging of tRNA isoacceptors during amino acid limitation.

Elf, Johan; Tenson, Tanel; Ehrenberg, Måns

Part of Science, p. 1718-1722, 2003

Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome

Ullers, R S; Houben, E N G; Raine, A; ten Hagen-Jongman, C M et al.

Part of J. Cell Biology, p. 679-684, 2003

The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome.

Tenson, Tanel; Lovmar, Martin; Ehrenberg, Måns

Part of J Mol Biol, p. 1005-14, 2003

Targeting and insertion of heterologous membrane proteins in E. coli

Raine, A; Ullers, R; Pavlov, M; Luirink, J et al.

Part of Biochimie, p. 659-668, 2003

A new beginning of the end of translation

Ehrenberg, M; Tenson, T

Part of journal, p. 85-87, 2002

Substrate-Induced Formation of Ribosomal Decoding Center for Accurate and Rapid Genetic Code Translation

Pavlov, Michael; Ehrenberg, Måns

Part of Annual Review of Biophysics, p. 525-548, 2018

• DOI for Substrate-Induced Formation of Ribosomal Decoding Center for Accurate and Rapid Genetic Code Translation

A recent intermezzo at the Ribosome Club

Pavlov, Michael; Liljas, Anders; Ehrenberg, Måns

Part of Philosophical Transactions of the Royal Society of London. Biological Sciences, 2017

• DOI for A recent intermezzo at the Ribosome Club
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Medium-dependent control of the bacterial growth rate

Ehrenberg, Måns; Bremer, Hans; Dennis, Patrick P.

Part of Biochimie, p. 643-658, 2013

• DOI for Medium-dependent control of the bacterial growth rate

Rate and accuracy of bacterial protein synthesis revisited

Johansson, Magnus; Lovmar, Martin; Ehrenberg, Måns

Part of Current Opinion in Microbiology, p. 141-147, 2008

• DOI for Rate and accuracy of bacterial protein synthesis revisited

The role of tRNA as a molecular spring in decoding, accommodation, and peptidyl transfer.

Frank, Joachim; Sengupta, Jayati; Gao, Haixiao; Li, Wen et al.

Part of FEBS Lett, p. 959-62, 2005

Control of rRNA synthesis in Escherichia coli: a systems biology approach.

Dennis, Patrick P; Ehrenberg, Måns; Bremer, Hans

Part of Microbiol Mol Biol Rev, p. 639-68, 2004

A cryo-electron microscopic study of ribosome-bound termination factor RF2

Rawat, Urmila B.S.; Zavialov, Andrey; Sengupta, Jayati; Valle, Mikel et al.

Part of Nature, p. 87-90, 2003

Structural aspects of protein synthesis

Liljas, Anders; Ehrenberg, Måns

World Scientific, 2013

The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

Fu, Ziao; Indrisiunaite, Gabriele; Kaledhonkar, Sandip; Shah, Binita et al.

Part of Novel Developments in Cryo EM of Biological Molecules, p. 481-500, Jenny Stanford Publishing, 2023

• DOI for The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

Large DNA Template Dependent Error Variation During Transcription

Mellenius, Harriet; Ehrenberg, Måns

Part of Biophysics and Structure to Counter Threats and Challenges, p. 39-57, Springer Netherlands, 2014

• DOI for Large DNA Template Dependent Error Variation During Transcription

Translation Termination, the Prion [Psi+], and Ribosomal Recycling

Ehrenberg, Måns; Hauryliuk, Vasili; Crist, Colin G; Nakamura, Yoshikazu

Part of Translational Control in Biology and Medicine, p. 173-196, Cold Spring Harbor Laboratory Press, 2007

Mesoscopic kinetics and its applications in protein synthesis

Elf, Johan; Paulsson, Johan; Berg, Otto; Ehrenberg, Måns

Part of Systems Biology, p. 95-118, Springer-Verlag GmbH, 2005

• DOI for Mesoscopic kinetics and its applications in protein synthesis

Rate and accuracy of ribosomal peptidyl transfer

Johansson, Magnus; Ieong, Ka-Weng; Pavlov, Michael Y.; Ehrenberg, Måns

Part of Ribosomes, p. 225-235, 2011

Initiation of bacterial protein synthesis with wild type and novel mutants of initiation factor

Pavlov, Michael Y.; Sanyal, Suparna; Ehrenberg, Måns

Part of Ribosomes, p. 129-141, 2011

A novel mechanism for activator-controlled initiation of DNA replication that resolves the auto-regulation sequestration paradox

Nilsson, Karin; Ehrenberg, Måns

Part of ASPECTS OF PHYSICAL BIOLOGY: BIOLOGICAL WATER, PROTEIN SOLUTIONS, TRANSPORT AND REPLICATION, p. 189-213, 2008

• DOI for A novel mechanism for activator-controlled initiation of DNA replication that resolves the auto-regulation sequestration paradox

N⁶-methyladenosines in mRNA have profound effects on the accuracy of codon reading by tRNAs and peptide release factors

Ieong, Ka-Weng; Indrisiunaite, Gabriele; Ehrenberg, Måns