Per Artursson

Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel et al.

Part of Scientific Reports, 2019

• DOI for Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations
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A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas et al.

Part of Archives of Toxicology, p. 819-829, 2019

• DOI for A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes
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Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids

Treyer, Andrea; Mateus, André; Wisniewski, Jacek R.; Boriss, Hinnerk et al.

Part of Molecular Pharmaceutics, p. 2224-2233, 2018

• DOI for Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids
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Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Mateus, André; Treyer, Andrea; Wegler, Christine; Karlgren, Maria et al.

Part of Scientific Reports, p. 1-12, 2017

• DOI for Intracellular drug bioavailability: a new predictor of system dependent drug disposition
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Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Wegler, Christine; Gaugaz, Fabienne Z.; Andersson, Tommy B.; Wisniewsk, Jacek R. et al.

Part of Molecular Pharmaceutics, p. 3142-3151, 2017

• DOI for Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes
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Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Mateus, André; Gordon, Laurie J.; Wayne, Gareth J.; Almqvist, Helena et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2017

• DOI for Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Almqvist, Helena; Axelsson, Hanna; Jafari, Rozbeh; Dan, Chen et al.

Part of Nature Communications, 2016

• DOI for CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
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Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Simoff, Ivailo; Karlgren, Maria; Backlund, Maria; Lindström, Anne-Christine et al.

Part of Journal of Pharmaceutical Sciences, p. 1017-1021, 2016

• DOI for Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Structural and conformational determinants of macrocycle cell permeability

Over, Bjorn; Matsson, Pär; Tyrchan, Christian; Artursson, Per et al.

Part of Nature Chemical Biology, p. 1065-+, 2016

• DOI for Structural and conformational determinants of macrocycle cell permeability

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Lundquist, Patrik; Artursson, Per

Part of Advanced Drug Delivery Reviews, p. 256-276, 2016

• DOI for Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
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Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier

Lundquist, Patrik; Hagforsen, Eva; Wagner, Michael; Alimohammadi, Mohammad et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI for Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier
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Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier

Zhou, Xujia; Azimi, Mina; Handin, Niklas; Riselli, Andrew et al.

2024

• DOI for Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier
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Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack

van Rijn, jorva668; Lopes, Ana; Ceylan, Merve; Eriksson, Jens et al.

Part of Cell Reports, 2024

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Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

Yee, Sook Wah; Ferrández-Peral, Luis; Alentorn-Moron, Pol; Fontsere, Claudia et al.

Part of Nature Communications, 2024

• DOI for Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates
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Global ¹³C tracing and metabolic flux analysis of intact human liver tissue ex vivo

Grankvist, Nina; Jönsson, Cecilia; Hedin, Karin; Sundqvist, Nicolas et al.

Part of Nature Metabolism, p. 1963-1975, 2024

• DOI for Global ¹³C tracing and metabolic flux analysis of intact human liver tissue ex vivo
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Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier

Lundquist, Patrik; Hagforsen, Eva; Wagner, Michael; Alimohammadi, Mohammad et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI for Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier
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Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack

van Rijn, jorva668; Lopes, Ana; Ceylan, Merve; Eriksson, Jens et al.

Part of Cell Reports, 2024

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Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

Yee, Sook Wah; Ferrández-Peral, Luis; Alentorn-Moron, Pol; Fontsere, Claudia et al.

Part of Nature Communications, 2024

• DOI for Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates
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Global ¹³C tracing and metabolic flux analysis of intact human liver tissue ex vivo

Grankvist, Nina; Jönsson, Cecilia; Hedin, Karin; Sundqvist, Nicolas et al.

Part of Nature Metabolism, p. 1963-1975, 2024

• DOI for Global ¹³C tracing and metabolic flux analysis of intact human liver tissue ex vivo
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Part of Scientific Reports, 2024

• DOI for OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
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Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals

Kvitne, Kine Eide; Hovd, Markus; Johnson, Line Kristin; Wegler, Christine et al.

Part of Clinical Pharmacokinetics, p. 109-120, 2024

• DOI for Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals
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In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants

Kölz, Charlotte; Gaugaz, Fabienne Z.; Handin, Niklas; Schaeffeler, Elke et al.

Part of British Journal of Pharmacology, 2024

• DOI for In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Part of EBioMedicine, 2024

• DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function

Xing, Chen; Kemas, Aurino; Mickols, Evgeniya; Klein, Kathrin et al.

Part of Biotechnology Journal, 2024

• DOI for The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function
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Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

de Waal, Tom; Handin, Niklas; Brouwers, Joachim; Miserez, Marc et al.

Part of International Journal of Pharmaceutics, 2024

• DOI for Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane

Nichols, Aaron L.; Blumenfeld, Zack; Luebbert, Laura; Knox, Hailey J. et al.

Part of Journal of Neuroscience, p. 2222-2241, 2023

• DOI for Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
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Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis

Handin, Niklas; Yuan, Di; Olander, Magnus; Wegler, Christine et al.

Part of Computational and Structural Biotechnology Journal, p. 4361-4369, 2023

• DOI for Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis
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Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance

Hovd, Markus; Robertsen, Ida; Johnson, Line Kristin; Krogstad, Veronica et al.

Part of Clinical Pharmacokinetics, p. 725-735, 2023

• DOI for Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance
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Epithelial and microbial determinants of colonic drug distribution

Hammar, Rebekkah; Sellin, Mikael E.; Artursson, Per

Part of European Journal of Pharmaceutical Sciences, 2023

• DOI for Epithelial and microbial determinants of colonic drug distribution
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Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

Tremmel, Roman; Nies, Anne T.; van Eijck, Barbara A. C.; Handin, Niklas et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation
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Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko et al.

Part of Biomedicine and Pharmacotherapy, 2022

• DOI for Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
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Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

Part of Nucleic Acids Research, 2022

• DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
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Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat

Lundquist, Patrik; Khodus, Georgiy; Niu, Zhigao; Thwala, Lungile Nomcebo et al.

Part of ACS Nano, p. 14210-14229, 2022

• DOI for Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat
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Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Wegler, Christine; Wiśniewski, Jacek R; Robertsen, Ida; Christensen, Hege et al.

Part of Clinical Pharmacology and Therapeutics, p. 1142-1154, 2022

• DOI for Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity
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Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial

Kvitne, Kine Eide; Robertsen, Ida; Skovlund, Eva; Christensen, Hege et al.

Part of Clinical and Translational Science, p. 221-233, 2022

• DOI for Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial
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High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3

Chen, Eugene C.; Matsson, Pär; Azimi, Mina; Zhou, Xujia et al.

Part of Pharmaceutical research, p. 1599-1613, 2022

• DOI for High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3
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Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

Kvitne, Kine Eide; Krogstad, Veronica; Wegler, Christine; Johnson, Line Kristin et al.

Part of British Journal of Clinical Pharmacology, p. 4121-4133, 2022

• DOI for Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity
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Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity

Kvitne, Kine Eide; Asberg, Anders; Johnson, Line K.; Wegler, Christine et al.

Part of Clinical and Translational Science, p. 2685-2696, 2022

• DOI for Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity
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The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients

de Waal, Tom; Handin, Niklas; Brouwers, Joachim; Ferrante, Marc et al.

Part of International Journal of Pharmaceutics, 2022

• DOI for The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients

Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range

Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene et al.

Part of European Journal of Clinical Pharmacology, p. 1289-1299, 2022

• DOI for Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range
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Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Loryan, Irena; Smith, David E.; Artursson, Per; Breimer, Douwe et al.

Part of Pharmaceutical research, p. 1283-1289, 2022

• DOI for Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P. et al.

Part of Journal of Experimental & Clinical Cancer Research, 2021

• DOI for Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
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Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Handin, Niklas; Mickols, Evgeniya; Ölander, Magnus; Rudfeldt, Jakob et al.

Part of iScience, 2021

• DOI for Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
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Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S. et al.

Part of Journal of Pharmaceutical Sciences, p. 239-250, 2021

• DOI for Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease
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Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

Wegler, Christine; Prieto Garcia, Luna; Klinting, Signe; Robertsen, Ida et al.

Part of Clinical Pharmacology and Therapeutics, p. 762-771, 2021

• DOI for Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight
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Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer

Flörkemeier, Inken; Steinhauer, Tamara N.; Hedemann, Nina; Ölander, Magnus et al.

Part of THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021

• DOI for Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer
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Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay et al.

Part of Journal of Pharmaceutical Sciences, p. 388-396, 2021

• DOI for Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
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Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Wegler, Christine; Matsson, Pär; Krogstad, Veronica; Urdzik, Jozef et al.

Part of Molecular Pharmaceutics, p. 1792-1805, 2021

• DOI for Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes
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Getting a grip with kirigami

Teleki, Alexandra; Artursson, Per

Part of Nature Materials, p. 1043-1044, 2021

• DOI for Getting a grip with kirigami

Hepatocyte size fractionation allows dissection of human liver zonation

Ölander, Magnus; Wegler, Christine; Flörkemeier, Inken; Treyer, Andrea et al.

Part of Journal of Cellular Physiology, p. 5885-5894, 2021

• DOI for Hepatocyte size fractionation allows dissection of human liver zonation
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Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

Part of Pharmaceutics, 2020

• DOI for Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
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Cell-type-resolved proteomic analysis of the human liver

Ölander, Magnus; Wiśniewski, Jacek R.; Artursson, Per

Part of Liver international, p. 1770-1780, 2020

• DOI for Cell-type-resolved proteomic analysis of the human liver
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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Part of Nature Communications, 2020

• DOI for Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
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Global variability analysis of mRNA and protein concentrations across and within human tissues

Wegler, Christine; Ölander, Magnus; Wiśniewski, Jacek R; Lundquist, Patrik et al.

Part of NAR Genomics and Bioinformatics, 2020

• DOI for Global variability analysis of mRNA and protein concentrations across and within human tissues
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A new opening for orally taken peptide drugs

Artursson, Per; Lundquist, Patrik

Part of Nature Biomedical Engineering, p. 12-13, 2020

• DOI for A new opening for orally taken peptide drugs

A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K. et al.

Part of Drug Metabolism And Disposition, p. 8-17, 2020

• DOI for A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

Part of Journal of Proteome Research, p. 217-224, 2019

• DOI for Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking
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Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel et al.

Part of Scientific Reports, 2019

• DOI for Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations
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Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Treyer, Andrea; Ullah, Mohammed; Parrott, Neil; Molitor, Birgit et al.

Part of AAPS Journal, 2019

• DOI for Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies
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Image-based quantification of cell debris as a measure of apoptosis

Ölander, Magnus; Handin, Niklas; Artursson, Per

Part of Analytical Chemistry, p. 5548-5552, 2019

• DOI for Image-based quantification of cell debris as a measure of apoptosis
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Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

Nies, A. T.; Handin, Niklas; Schaeffeler, E.; Haag, M. et al.

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, 2019

• DOI for Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas et al.

Part of Archives of Toxicology, p. 819-829, 2019

• DOI for A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes
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A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär et al.

Part of Pharmaceutical research, 2019

• DOI for A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))
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Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A. et al.

Part of Clinical Pharmacology and Therapeutics, p. 525-543, 2019

• DOI for Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Experimental approaches to understand intracellular based drug bioavailability

Artursson, Per

Part of Drug Metabolism and Pharmacokinetics, 2019

• DOI for Experimental approaches to understand intracellular based drug bioavailability

Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

Weiss, Frederik; Hammer, Helen S.; Klein, Kathrin; Planatscher, Hannes et al.

Part of Drug Metabolism And Disposition, p. 387-396, 2018

• DOI for Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates
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Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Padhan, Narendra et al.

Part of Genome Medicine, 2018

• DOI for Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

Islam, Md. Koushikul; Strand, Mårten; Saleeb, Michael; Svensson, Richard et al.

Part of Scientific Reports, 2018

• DOI for Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound
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Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Visnes, Torkild; Cazares-Korner, Armando; Hao, Wenjing; Wallner, Olov et al.

Part of Science, p. 834-839, 2018

• DOI for Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids

Treyer, Andrea; Mateus, André; Wisniewski, Jacek R.; Boriss, Hinnerk et al.

Part of Molecular Pharmaceutics, p. 2224-2233, 2018

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The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers

Shrestha, Neha; Bouttefeux, Oriane; Vanvarenberg, Kevin; Lundquist, Patrik et al.

Part of Nanoscale, p. 603-613, 2018

• DOI for The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers

Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines

Llona-Minguez, Sabin; Ghassemian, Artin; Baranczewski, Pawel; Desroses, Matthieu et al.

Part of MedChemComm, p. 1553-1560, 2017

• DOI for Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines

A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation

Beloqui, Ana; Brayden, David J.; Artursson, Per; Preat, Veronique et al.

Part of Nature Protocols, p. 1387-1399, 2017

• DOI for A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation

Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Mateus, André; Treyer, Andrea; Wegler, Christine; Karlgren, Maria et al.

Part of Scientific Reports, p. 1-12, 2017

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Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)

Pedersen, Jenny M.; Khan, Elin K.; Bergström, Christel; Palm, Johan et al.

Part of European Journal of Pharmaceutical Sciences, p. 70-76, 2017

• DOI for Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Wegler, Christine; Gaugaz, Fabienne Z.; Andersson, Tommy B.; Wisniewsk, Jacek R. et al.

Part of Molecular Pharmaceutics, p. 3142-3151, 2017

• DOI for Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes
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A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Karlgren, Maria; Simoff, Ivailo; Backlund, Maria; Wegler, Christine et al.

Part of Journal of Pharmaceutical Sciences, p. 2909-2913, 2017

• DOI for A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1

Llona-Minguez, Sabin; Höglund, Andreas; Wiita, Elisee; Almlof, Ingrid et al.

Part of Journal of Medicinal Chemistry, p. 2148-2154, 2017

• DOI for Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Mateus, André; Gordon, Laurie J.; Wayne, Gareth J.; Almqvist, Helena et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2017

• DOI for Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

Llona-Minguez, Sabin; Höglund, Andreas; Ghassemian, Artin; Desroses, Matthieu et al.

Part of Journal of Medicinal Chemistry, p. 4279-4292, 2017

• DOI for Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases

Urdzik, Jozef; Vildhede, Anna; Wiśniewski, Jacek R.; Duraj, Frans et al.

Part of PROTEOMES, 2016

• DOI for Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases
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Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Vanga, Sudarsana Reddy et al.

Part of ACS Chemical Neuroscience, p. 1383-1392, 2016

• DOI for Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Validation and development of MTH1 inhibitors for treatment of cancer

Berglund, U. Warpman; Sanjiv, K.; Gad, H.; Kalderen, C. et al.

Part of Annals of Oncology, p. 2275-2283, 2016

• DOI for Validation and development of MTH1 inhibitors for treatment of cancer
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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Almqvist, Helena; Axelsson, Hanna; Jafari, Rozbeh; Dan, Chen et al.

Part of Nature Communications, 2016

• DOI for CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
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Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Simoff, Ivailo; Karlgren, Maria; Backlund, Maria; Lindström, Anne-Christine et al.

Part of Journal of Pharmaceutical Sciences, p. 1017-1021, 2016

• DOI for Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions

Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

Part of Analytical Biochemistry, p. 82-88, 2016

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Development of MS- based immunoassays for Cytochrome P450 and transporter quantification

Hammer, H. S.; Poetz, O.; Artursson, Per; Wegler, Christine

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, 2016

Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison

Wegler, Christine; Gaugaz, Fabienne Z.; Andersson, Tommy B.; Wisniewski, Jacek R. et al.

Part of Drug metabolism reviews (Softcover ed.), p. 98-98, 2016

The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition

Ölander, Magnus; Wiśniewski, Jacek R.; Matsson, Pär; Lundquist, Patrik et al.

Part of Journal of Pharmaceutical Sciences, p. 817-827, 2016

• DOI for The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition

Impact of drug transporters on intracellular unbound drug concentrations

Mateus, André; Treyer, Andrea; Matsson, Par; Karlgren, Maria et al.

Part of Drug metabolism reviews (Softcover ed.), p. 147-147, 2016

Structural and conformational determinants of macrocycle cell permeability

Over, Bjorn; Matsson, Pär; Tyrchan, Christian; Artursson, Per et al.

Part of Nature Chemical Biology, p. 1065-+, 2016

• DOI for Structural and conformational determinants of macrocycle cell permeability

The Need for Speed-Kinetic Limits of Drug Transporters

Matsson, Pär X.; Lundquist, Patrik; Artursson, Per

Part of TIPS - Trends in Pharmacological Sciences, p. 243-245, 2016

• DOI for The Need for Speed-Kinetic Limits of Drug Transporters

Comparative proteome analysis of human liver tissue and isolated hepatocytes: application to predictions of hepatic pitavastatin uptake clearance

Vildhede, Anna; Wisniewski, Jacek; Norén, Agneta; Karlgren, Maria et al.

Part of Drug metabolism reviews (Softcover ed.), p. 96-96, 2016

To attach or not to attach: factors behind variable adhesion properties of cryopreserved human hepatocytes

Ölander, Magnus; Wisniewski, Jacek; Norén, Agneta; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 103-103, 2016

Mechanistic modeling of hepatic pitavastatin disposition: a proteomics-informed bottom-up approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Part of Drug metabolism reviews (Softcover ed.), p. 56-57, 2016

New cell-based approaches for better predictions of drug transport and cellular drug exposure

Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 7-7, 2016

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Part of Drug Metabolism And Disposition, p. 505-516, 2016

• DOI for Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

Good, James A. D.; Silver, Jim; Nunez-Otero, Carlos; Bahnan, Wael et al.

Part of Journal of Medicinal Chemistry, p. 2094-2108, 2016

• DOI for Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

Gordon, Laurie J; Allen, Morven; Artursson, Per; Hann, Michael M. et al.

Part of Journal of Biomolecular Screening, p. 156-164, 2016

• DOI for Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

A Tribute to Ronald T. Borchardt-Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Schowen, Katharine Barbara; Schowen, Richard L.; Borchardt, Susan E.; Borchardt, Paul M. et al.

Part of Journal of Pharmaceutical Sciences, p. 370-385, 2016

• DOI for A Tribute to Ronald T. Borchardt-Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Llona-Minguez, Sabin; Höglund, Andreas; Jacques, Sylvain A.; Johanson, Lars et al.

Part of Journal of Medicinal Chemistry, p. 1140-1148, 2016

• DOI for Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells

Miyake, Masateru; Ragnarsson, Eva; Nakai, Daisuke; Artursson, Per

Part of Journal of Pharmaceutical Sciences, p. 2099-2104, 2016

• DOI for The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

Wisniewski, Jacek R.; Vildhede, Anna; Norén, Agneta; Artursson, Per

Part of Journal of Proteomics, p. 234-247, 2016

• DOI for In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes
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Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Vildhede, Anna; Wisniewski, Jacek R.; Noren, Agneta; Karlgren, Maria et al.

Part of Journal of Proteome Research, p. 3305-3314, 2015

• DOI for Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Addendum to 'Quantifying the impact of transporters on cellular drug permeability'

Matsson, Pär; Fenu, Luca A.; Lundquist, Patrik; Wisniewski, Jacek R. et al.

Part of TIPS - Trends in Pharmacological Sciences, p. 559-559, 2015

• DOI for Addendum to 'Quantifying the impact of transporters on cellular drug permeability'

Quantifying the impact of transporters on cellular drug permeability.

Matsson, Pär; Fenu, Luca A; Lundquist, Patrik; Wiśniewski, Jacek R et al.

Part of TIPS - Trends in Pharmacological Sciences, p. 255-262, 2015

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Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Borhade, Sanjay R.; Svensson, Richard; Brandt, Peter; Artursson, Per et al.

Part of ChemMedChem, p. 455-460, 2015

• DOI for Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Global Membrane Protein Analysis Of The Human Liver: Application In Predictions Of Atorvastatin Uptake Clearance

Karlgren, Maria; Vildhede, Anna; Ölander, Magnus; Wisniewski, Jacek et al.

Part of Drug metabolism reviews (Softcover ed.), p. 245-246, 2015

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

Caraballo, Remi; Larsson, Mikael; Nilsson, Stefan K.; Ericsson, Madelene et al.

Part of European Journal of Medicinal Chemistry, p. 191-209, 2015

• DOI for Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

Breaking the intestinal barrier to deliver drugs

Artursson, Per; Knight, Stefan

Part of Science, p. 716-717, 2015

• DOI for Breaking the intestinal barrier to deliver drugs

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014

• DOI for Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna et al.

Part of ACS Medicinal Chemistry Letters, p. 1272-1277, 2014

• DOI for Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014

• DOI for Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Bergström, Christel A. S.; Holm, Rene; Jorgensen, Soren Astrup; Andersson, Sara B. E. et al.

Part of European Journal of Pharmaceutical Sciences, p. 173-199, 2014

• DOI for Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Gad, Helge; Koolmeister, Tobias; Jemth, Ann-Sofie; Eshtad, Saeed et al.

Part of Nature, p. 215-221, 2014

• DOI for MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Kitambi, Satish Srinivas; Toledo, Enrique M.; Usoskin, Dmitry; Wee, Shimei et al.

Part of Cell, p. 313-328, 2014

• DOI for Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Over, Bjorn; McCarren, Patrick; Artursson, Per; Foley, Michael et al.

Part of Journal of Medicinal Chemistry, p. 2746-2754, 2014

• DOI for Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain

Mateus, André; Matsson, Pär; Artursson, Per

Part of Journal of Medicinal Chemistry, p. 3005-3010, 2014

• DOI for A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014

• DOI for Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Vildhede, Anna; Karlgren, Maria; Svedberg, Elin K.; Wisniewski, Jacek R. et al.

Part of Drug Metabolism And Disposition, p. 1210-1218, 2014

• DOI for Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Pedersen, Jenny M.; Matsson, Pär; Bergström, Christel A. S.; Hoogstraate, Janet et al.

Part of Toxicological Sciences, p. 328-343, 2013

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Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler, Ulrika; Fagerberg, Jonas H.; Svensson, Richard; Larhed, Mats et al.

Part of Journal of Medicinal Chemistry, p. 2690-2694, 2013

• DOI for Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Computational Prospecting for Drug-Transporter Interactions

Matsson, Pär; Artursson, Per

Part of Clinical Pharmacology and Therapeutics, p. 30-32, 2013

• DOI for Computational Prospecting for Drug-Transporter Interactions

Rapid Measurement of Intracellular Unbound Drug Concentrations

Mateus, André; Matsson, Pär; Artursson, Per

Part of Molecular Pharmaceutics, p. 2467-2478, 2013

• DOI for Rapid Measurement of Intracellular Unbound Drug Concentrations

Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1

Ohrvik, Helena; Tydén, Eva; Artursson, Per; Oskarsson, Agneta et al.

Part of ISRN Toxicology, 2013

• DOI for Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Part of Journal of Medicinal Chemistry, p. 4953-4965, 2013

• DOI for Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Neve, Etienne P. A.; Artursson, Per; Ingelman-Sundberg, Magnus; Karlgren, Maria

Part of Molecular Pharmaceutics, p. 3152-3163, 2013

• DOI for An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Matsson, Elin M.; Eriksson, Ulf G.; Palm, Johan E.; Artursson, Per et al.

Part of Molecular Pharmaceutics, p. 4252-4262, 2013

• DOI for Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat

Johansson, Carl-Christer; Gennemark, Peter; Artursson, Per; Abelo, Angela et al.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 117-128, 2013

• DOI for Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat

The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Prieto, P.; Kinsner-Ovaskainen, A.; Stanzel, S.; Albella, B. et al.

Part of Toxicology in Vitro, p. 1357-1376, 2013

• DOI for The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Part of Pharmaceutical research, p. 411-426, 2012

• DOI for In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Karlgren, Maria; Vildhede, Anna; Norinder, Ulf; Wisniewski, Jacek R. et al.

Part of Journal of Medicinal Chemistry, p. 4740-4763, 2012

• DOI for Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

mRNA expression of drug-transporting proteins along the human intestine and comparison with expression in Caco-2 cells

Englund, Gunilla; Rorsman, Fredrik; Rönnblom, Anders; Lazorova, Lucia et al.

2012

Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Lazorova, Lucia; Hubatsch, Ina; Ekegren, Jenny K.; Gising, Johan et al.

Part of Journal of Pharmaceutical Sciences, p. 3763-3772, 2011

• DOI for Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions

Ahlin, Gustav; Chen, L; Lazorova, Lucia; Chen, Ying et al.

Part of The Pharmacogenomics Journal, p. 400-411, 2011

• DOI for Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions

A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Zaki, Noha M.; Artursson, Per; Bergström, Christel A. S.

Part of Molecular pharmaceutics, p. 1478-1487, 2010

• DOI for A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel; Karlsson, Johan et al.

Part of Drug metabolism reviews (Softcover ed.), p. 304-305, 2010

In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation

Bose, Partha Pratim; Chatterjee, Urmimala; Hubatsch, Ina; Artursson, Per et al.

Part of Bioorganic & Medicinal Chemistry, p. 5896-5902, 2010

• DOI for In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation

Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

Linnankoski, Johanna; Mäkelä, Johanna; Palmgren, Joni; Mauriala, Timo et al.

Part of Journal of Pharmaceutical Sciences, p. 2166-2175, 2010

• DOI for Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking

Strand, Sabina P; Lelu, Sylvie; Reitan, Nina K; de Lange Davies, Catharina et al.

Part of Biomaterials, p. 975-987, 2010

• DOI for Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking

Coexistence of passive and carrier-mediated processes in drug transport

Sugano, Kiyohiko; Kansy, Manfred; Artursson, Per; Avdeef, Alex et al.

Part of Nature reviews. Drug discovery, p. 597-614, 2010

• DOI for Coexistence of passive and carrier-mediated processes in drug transport

Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte

Karlgren, Maria; Svensson, Richard; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 306-307, 2010

Uptake mechanism of ochratoxin A and citrinin through human liver

Gao, Ge; Karlgren, Maria; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 315-315, 2010

Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1)

Karlgren, Maria; Ahlin, Gustav; Vildhede, Anna; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 305-306, 2010

Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Bergström, Christel A S; Bolin, Sara; Artursson, Per; Rönn, Robert et al.

Part of European Journal of Pharmaceutical Sciences, p. 556-563, 2009

• DOI for Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Matsson, Pär; Pedersen, Jenny M; Norinder, Ulf; Bergström, Christel A S et al.

Part of Pharmaceutical research, p. 1816-1831, 2009

• DOI for Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs

Ahlin, Gustav; Hilgendorf, Constanze; Karlsson, Johan; Al-Khalili Szigyarto, Cristina et al.

Part of Drug Metabolism And Disposition, p. 2275-2283, 2009

• DOI for Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Ahlin, Gustav; Karlsson, Johan; Pedersen, Jenny M; Gustavsson, Lena et al.

Part of Journal of Medicinal Chemistry, p. 5932-5942, 2008

• DOI for Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Molecular characteristics for solid-state limited solubility

Wassvik, Carola M; Holmén, Anders G; Draheim, Rieke; Artursson, Per et al.

Part of Journal of Medicinal Chemistry, p. 3035-3039, 2008

• DOI for Molecular characteristics for solid-state limited solubility

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Pedersen, Jenny; Matsson, Pär; Norinder, Ulf; Bergström, Christel A. S. et al.

Part of Journal of Medicinal Chemistry, p. 3275-3287, 2008

• DOI for Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis

Ragnarsson, Eva G E; Schoultz, Ida; Gullberg, Elisabet; Carlsson, Anders H et al.

Part of Laboratory investigation; a journal of technical methods and pathology, p. 1215-26, 2008

• DOI for Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Hayeshi, Rose; Hilgendorf, Constanze; Artursson, Per; Augustijns, Patrick et al.

Part of European Journal of Pharmaceutical Sciences, p. 383-396, 2008

• DOI for Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties

Strand, Sabina P; Issa, Mohamed M; Christensen, Bjørn E; Vårum, Kjell M et al.

Part of Biomacromolecules, p. 3268-76, 2008

• DOI for Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties

A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Matsson, Pär; Englund, Gunilla; Ahlin, Gustav; Bergström, Christel A. S. et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 19-30, 2007

• DOI for A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers

Neuhoff, Sibylle; Artursson, Per; Ungell, Anna-Lena

Part of Journal of drug delivery science and technology, p. 259-266, 2007

Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1

Hubatsch, Ina; Arvidsson, Per I.; Seebach, Dieter; Luthman, Kristina et al.

Part of Journal of Medicinal Chemistry, p. 5238-5242, 2007

• DOI for Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1

Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

Hubatsch, Ina; Ragnarsson, Eva G E; Artursson, Per

Part of Nature Protocols, p. 2111-2119, 2007

• DOI for Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Hilgendorf, Constanze; Ahlin, Gustav; Seithel, Annick; Artursson, Per et al.

Part of Drug Metabolism And Disposition, p. 1333-1340, 2007

• DOI for Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)

Englund, Gunilla; Jacobson, Annica; Rorsman, Fredrik; Artursson, Per et al.

Part of Inflammatory Bowel Diseases, p. 291-297, 2007

• DOI for Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)

Contribution of solid-state properties to the aqueous solubility of drugs.

Wassvik, Carola; Holmén, Anders; Bergström, Christel; Zamora, Ismael et al.

Part of Eur J Pharm Sci, p. 294-305, 2006

Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo

Issa, Mohamed; Köping-Höggård, Magnus; Tammeraas, Kristoffer; Vårum, Kjell M. et al.

Part of Journal of Controlled Release, p. 103-112, 2006

• DOI for Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo

Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches

Gullberg, Elisabet; Keita, Åsa V.; Salim, Sa'ad Y.; Andersson, Margaretha et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 632-639, 2006

• DOI for Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches

Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells

Englund, Gunilla; Rorsman, Fredrik; Rönnblom, Anders; Karlbom, Urban et al.

Part of European Journal of Pharmaceutical Sciences, p. 269-277, 2006

• DOI for Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells

Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery

Regnström, Karin; Ragnarsson, Eva GE; Fryknäs, Mårten; Köping-Höggård, Magnus et al.

Part of Pharmaceutical research, p. 475-482, 2006

• DOI for Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery

Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.

Sai, Yoshimichi; Kaneko, Yosuke; Ito, Satsuki; Mitsuoka, Keisuke et al.

Part of Drug Metab Dispos, p. 1423-31, 2006

Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum.

Keita, Åsa V; Gullberg, Elisabet; Ericson, Ann-Charlott; Salim, Sa'ad Y et al.

Part of Lab Invest, p. 504-16, 2006

Impact of extracellular protein binding on passive and active drug transport across Caco-2 cells.

Neuhoff, Sibylle; Artursson, Per; Zamora, Ismael; Ungell, Anna-Lena

Part of Pharm Res, p. 350-9, 2006

X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol.

Söderström, Johan; Gråsjö, Johan; Kashtanov, S; Bergström, Christel et al.

Part of J Electr Spectr, p. 283-285, 2005

Exploring the role of different drug transport routes in permeability screening.

Matsson, Pär; Bergström, Christel A S; Nagahara, Naoki; Tavelin, Staffan et al.

Part of J Med Chem, p. 604-13, 2005

Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium.

Hubatsch, Ina; Lazorova, Lucia; Vahlne, Anders; Artursson, Per

Part of Antimicrob Agents Chemother, p. 1087-92, 2005

Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pK flux a method.

Avdeef, Alex; Artursson, Per; Neuhoff, Sibylle; Lazorova, Lucia et al.

Part of Eur J Pharm Sci, p. 333-49, 2005

Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan microspheres.

Feith, G; Lindberg, S; Itoh, K; Okada, N et al.

Part of Int J Pharm, p. 127, 2005

Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.

Yasar, U; Annas, A; Svensson, J-O; Lazorova, L et al.

Part of Xenobiotica, p. 785-96, 2005

Characterization of Surface-Modified Nanoparticles for in Vivo Biointeraction. A Sedimentation Field Flow Fractionation Study

Andersson, Margaretha; Fromell, Karin; Gullberg, Elisabet; Artursson, Per et al.

Part of Analytical Chemistry, p. 5488-5493, 2005

A miniaturized nebulization catheter for improved gene delivery to the mouse lung.

Köping-Höggård, Magnus; Issa, Mohamed M; Köhler, Tamara; Tronde, Ann et al.

Part of J Gene Med, p. 1215-22, 2005

Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium.

des Rieux, Anne; Ragnarsson, Eva G E; Gullberg, Elisabet; Preat, Veronique et al.

Part of Eur J Pharm Sci, p. 455-65, 2005

Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

Englund, Gunilla; Hallberg, Pär; Artursson, Per; Michaëlsson, Karl et al.

Part of BMC Medicine, 2004

• DOI for Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

Global and local computational models for aqueous solubility prediction of drug-like molecules.

Bergström, Christel A S; Wassvik, Carola M; Norinder, Ulf; Luthman, Kristina et al.

Part of J Chem Inf Comput Sci, p. 1477-88, 2004

Accuracy of calculated pH-dependent aqueous drug solubility.

Bergström, Christel A S; Luthman, Kristina; Artursson, Per

Part of Eur J Pharm Sci, p. 387-98, 2004

Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers.

Köping-Höggård, M; Vårum, K M; Issa, M; Danielsen, S et al.

Part of Gene Ther, p. 1441-52, 2004

Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs.

Nagahara, Naoki; Tavelin, Staffan; Artursson, Per

Part of J Pharm Sci, p. 2972-84, 2004

Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker ofMDR1-dependent drug efflux activity.

Taipalensuu, J; Tavelin, S; Lazorova, L; Svensson, AC et al.

Part of Eur J Pharm Sci, p. 69, 2004

Theoretical predictions of drug absorption in drug discovery and development 

Stenberg, Patric; Bergström, Christel; Luthman, Kristina; Artursson, Per

Part of Clinical Pharmacokinetics, p. 877-899, 2002

Expression of specific markers and particle transport in a new human intestinal M-cell model

Gullberg, Elisabet; Leonard, Maurice; Karlsson, Johan; Hopkins, Ann M. et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 808-813, 2000

• DOI for Expression of specific markers and particle transport in a new human intestinal M-cell model

Global expression variability of proteins across and within human tissues

Wegler, Christine; Ölander, Magnus; Wisniewski, Jacek R; Lundquist, Patrik et al.

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah et al.

Part of Advanced Drug Delivery Reviews, p. 289-331, 2021

• DOI for Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
• Download full text (pdf) of Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z. et al.

Part of ChemMedChem, p. 1862-1874, 2020

• DOI for The Critical Role of Passive Permeability in Designing Successful Drugs

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Karlgren, Maria; Simoff, Ivailo; Keiser, M.; Oswald, S. et al.

Part of Drug Metabolism And Disposition, p. 1776-1786, 2018

• DOI for CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Lundquist, Patrik; Artursson, Per

Part of Advanced Drug Delivery Reviews, p. 256-276, 2016

• DOI for Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
• Download full text (pdf) of Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Smith, Dennis; Artursson, Per; Avdeef, Alex; Di, Li et al.

Part of Molecular Pharmaceutics, p. 1727-1738, 2014

• DOI for Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Di, Li; Artursson, Per; Avdeef, Alex; Ecker, Gerhard F. et al.

Part of Drug Discovery Today, p. 905-912, 2012

• DOI for Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Caco-2 monolayers in experimental and theoretical predictions of drug transport

Artursson, Per; Palm, Katrin; Luthman, Kristina

Part of Advanced Drug Delivery Reviews, p. 280-289, 2012

• DOI for Caco-2 monolayers in experimental and theoretical predictions of drug transport

In vitro characterization of interactions with drug transporting proteins

Artursson, Per; Matsson, Pär; Karlgren, Maria

Part of Transporters in Drug Development , p. 37-65, Springer, 2013

• DOI for In vitro characterization of interactions with drug transporting proteins

Passive permeability and active transport models for the prediction of oral absorption

Artursson, P; Neuhoff, S; Tavelin, S; Matsson, P

Part of Comprehensive medicinal chemistry vol 5, p. 259-278, Elsevier, 2007

Cell culture absorption models - state of the art

Artursson, P; Matsson, P

Part of Pharmacokinetic profiling in drug research, p. 71, Wiley-VCH, Zürich, 2006

Absorption Prediction

Artursson, Per; Matsson, Pär

Part of Profiling in Drug Discovery for Lead Selection, AAPS Press, Arlington VA, 2004

Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier

Zhou, Xujia; Azimi, Mina; Handin, Niklas; Riselli, Andrew et al.

2024

• DOI for Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier
• Download full text (pdf) of Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier

Effects of obesity and weight loss on global protein expression in human liver and jejunum

Wegler, Christine; Robertsen, Ida; Wisniewski, Jacek R; Hjelmesæth, Jøran et al.

Transporter kinetics of the organic cation transporter OCT1 in 3D cultured primary human hepatocytes

Handin, Niklas; Meyer, Alina; Eriksson, Jens; Sellin, Mikael E. et al.

Proteomics-informed deconvolution of different cell types in human liver tissue

Handin, Niklas; Yuan, Di; Ölander, Magnus; Wegler, Christine et al.

Non-genetic and epigenetic factors contribute to inter-individualvariability of the hepatic bile acid and drug transporter NTCP: Hepatic variability of the hepatic bile acid and drug transporter NTCP

Tremmel, Roman; van Eijck, Barbara; Handin, Niklas; Haag, Mathias et al.

A Naked Host Cell Membrane is the Optimal Surface for Targeting by Salmonella

Geiser, Petra; Westman, Johanna; Ceylan, Merve; Bosman, Willem et al.

Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ

Al-Amin, Rasel A.; Johansson, Lars; Landegren, Nils; Löf, Liza et al.