Anders Karlén

Innovative roadmaps for sustainable antimicrobial resistance interventions

Gasperini, Gianmarco; Rossi Paccani, Silvia; O'Dwyer, Karen; Aanensen, David M. et al.

Part of Science Translational Medicine, 2026

• DOI for Innovative roadmaps for sustainable antimicrobial resistance interventions

The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships

Fernow, Josepine; Olliver, Marie; Couet, William; Lagrange, Sophie et al.

Part of Nature reviews. Drug discovery, p. 1-2, 2025

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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI for Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
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Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Benediktsdottir, Andrea; Sooriyaarachchi, Sanjeewani; Cao, Sha; Ottosson, Nina E. et al.

Part of European Journal of Medicinal Chemistry, 2024

• DOI for Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
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Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule

Grinkevich, Vera V.; Vema, Aparna; Fawkner, Karin; Issaeva, Natalia et al.

Part of Frontiers in Molecular Biosciences, 2022

• DOI for Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule
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The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships

Fernow, Josepine; Olliver, Marie; Couet, William; Lagrange, Sophie et al.

Part of Nature reviews. Drug discovery, p. 1-2, 2025

• DOI for The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships
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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI for Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
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Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Benediktsdottir, Andrea; Sooriyaarachchi, Sanjeewani; Cao, Sha; Ottosson, Nina E. et al.

Part of European Journal of Medicinal Chemistry, 2024

• DOI for Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
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Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule

Grinkevich, Vera V.; Vema, Aparna; Fawkner, Karin; Issaeva, Natalia et al.

Part of Frontiers in Molecular Biosciences, 2022

• DOI for Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule
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Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Part of ACS - Infectious Diseases, p. 482-498, 2022

• DOI for Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
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Bacterial type I signal peptidase inhibitors-Optimized hits from nature

Szalaj, Natalia; Benediktsdottir, Andrea; Rusin, Dominika; Karlén, Anders et al.

Part of European Journal of Medicinal Chemistry, 2022

• DOI for Bacterial type I signal peptidase inhibitors-Optimized hits from nature

Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Olanders, Gustav; Brandt, Peter; Sköld, Christian; Karlen, Anders

Part of Bioorganic & Medicinal Chemistry, 2021

• DOI for Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs
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ENABLE: an engine for European antibacterial drug discovery and development

Olliver, Marie; Griestop, Laura; Hughes, Diarmaid; Belfrage, Anna Karin et al.

Part of Nature reviews. Drug discovery, p. 407-408, 2021

• DOI for ENABLE: an engine for European antibacterial drug discovery and development

Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Benediktsdottir, Andrea; Lu, Lu; Cao, Sha; Zamaratski, Edouard et al.

Part of European Journal of Medicinal Chemistry, 2021

• DOI for Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation
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Conformational Analysis of Macrocycles: Comparing General and Specialized Methods

Olanders, Gustav; Alogheli, Hiba; Brandt, Peter; Karlén, Anders

Part of Journal of Computer-Aided Molecular Design, p. 231-252, 2020

• DOI for Conformational Analysis of Macrocycles: Comparing General and Specialized Methods
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Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Szałaj, Natalia; Lu, Lu; Benediktsdottir, Andrea; Zamaratski, Edouard et al.

Part of European Journal of Medicinal Chemistry, p. 1346-1360, 2018

• DOI for Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide

Alogheli, Hiba; Olanders, Gustav; Schaal, Wesley; Brandt, Peter et al.

Part of Journal of Chemical Information and Modeling, p. 190-202, 2017

• DOI for Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szałaj, Natalia et al.

Part of Bioorganic & Medicinal Chemistry, p. 897-911, 2017

• DOI for Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
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Predicting the Rate of Skin Penetration Using an Aggregated Conformal Prediction Framework

Lindh, Martin; Karlén, Anders; Norinder, Ulf

Part of Molecular Pharmaceutics, p. 1571-1576, 2017

• DOI for Predicting the Rate of Skin Penetration Using an Aggregated Conformal Prediction Framework

Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Lindh, Martin; Svensson, Fredrik; Schaal, Wesley; Zhang, Jin et al.

Part of Journal of Chemical Information and Modeling, p. 343-353, 2015

• DOI for Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Wallinder, Charlotta; Sköld, Christian; Botros, Milad; Guimond, Marie-Odile et al.

Part of ACS Medicinal Chemistry Letters, p. 178-182, 2015

• DOI for Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Phototriggerable peptidomimetics for the inhibition of Mycobacterium turberculosis ribonucleotide reductase by targeting protein-protein binding

Karlsson, Christoffer; Blom, Magnus; Johansson, Miranda; Jansson, Anna M. et al.

Part of Organic and biomolecular chemistry, p. 2612-2621, 2015

• DOI for Phototriggerable peptidomimetics for the inhibition of Mycobacterium turberculosis ribonucleotide reductase by targeting protein-protein binding

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Russo, Francesco; Gising, Johan; Åkerbladh, Linda; Roos, Annette K. et al.

Part of ChemistryOpen, p. 342-362, 2015

• DOI for Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents
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Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014

• DOI for Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014

• DOI for Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014

• DOI for Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic – targeting Mycobacterium tuberculosis ribonucleotide reductase

Nurbo, Johanna; Ericsson, Daniel J.; Rosenström, Ulrika; Muthas, Daniel et al.

Part of Bioorganic & Medicinal Chemistry, p. 1992-2000, 2013

• DOI for Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic – targeting Mycobacterium tuberculosis ribonucleotide reductase

DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Jansson, Anna; Więckowska, Anna; Björkelid, Christofer; Yahiaoui, Samir et al.

Part of Journal of Medicinal Chemistry, p. 6190-6199, 2013

• DOI for DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
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Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors

Nordqvist, Anneli; Nilsson, Mikael T.; Lagerlund, Olof; Muthas, Daniel et al.

Part of MedChemComm, p. 620-626, 2012

• DOI for Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors

Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

Svensson, Fredrik; Karlén, Anders; Sköld, Christian

Part of Journal of Chemical Information and Modeling, p. 225-232, 2012

• DOI for Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

Gising, Johan; Nilsson, Mikael T; Odell, Luke R; Yahiaoui, Samir et al.

Part of Journal of Medicinal Chemistry, p. 2894-2898, 2012

• DOI for Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
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Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase

Andaloussi, Mounir; Henriksson, Lena M.; Wieckowska, Anna; Lindh, Martin et al.

Part of Journal of Medicinal Chemistry, p. 4964-4976, 2011

• DOI for Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase
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Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis

Andaloussi, Mounir; Lindh, Martin; Björkelid, Christofer; Suresh, Surisetti et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 5403-5407, 2011

• DOI for Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis

Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

Andersson, Hanna; Demaegdt, Heidi; Johnsson, Anders; Vauquelin, Georges et al.

Part of Journal of Medicinal Chemistry, p. 3779-3792, 2011

• DOI for Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

P2-P1 ' macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Lampa, Anna; Ehrenberg, Angelica E.; Vema, Aparna; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 4917-4927, 2011

• DOI for P2-P1 ' macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors

Nordqvist, Anneli; Björkelid, Christofer; Andaloussi, Mounir; Jansson, Anna M. et al.

Part of Journal of Organic Chemistry, p. 8986-8998, 2011

• DOI for Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors
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Identification of small peptides mimicking the R2 C-terminus of Mycobacterium tuberculosis ribonucleotide reductase

Ericsson, Daniel J.; Nurbo, Johanna; Muthas, Daniel; Hertzberg, Kalle et al.

Part of Journal of Peptide Science, p. 159-164, 2010

• DOI for Identification of small peptides mimicking the R2 C-terminus of Mycobacterium tuberculosis ribonucleotide reductase

Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Lampa, Anna; Ehrenberg, Angelica E.; Gustafsson, Sofia S.; Vema, Aparna et al.

Part of Bioorganic & Medicinal Chemistry, p. 5413-5424, 2010

• DOI for Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Örtqvist, Pernilla; Vema, Aparna; Ehrenberg, Angelica E; Dahl, Göran et al.

Part of Antiviral Therapy, p. 841-852, 2010

• DOI for Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Örtqvist, Pernilla; Gising, Johan; Ehrenberg, Angelica; Vema, Aparna et al.

Part of Bioorganic & Medicinal Chemistry, p. 6512-6525, 2010

• DOI for Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)

Andersson, Hanna; Demaegdt, Heidi; Vauquelin, Georges; Lindeberg, Gunnar et al.

Part of Journal of Medicinal Chemistry, p. 8059-8071, 2010

• DOI for Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)

Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors

Ax, Anna; Joshi, Advait A.; Orrling, Kristina M.; Vrang, Lotta et al.

Part of Tetrahedron, p. 4049-4056, 2010

• DOI for Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors

Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

Nilsson, Mikael T.; Krajewski, Wojciech W.; Srinivasa, Bachally R.; Yahiaoui, Samir et al.

Part of Journal of Molecular Biology, p. 504-513, 2009

• DOI for Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors
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Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors

Odell, Luke R.; Nilsson, Mikael T.; Gising, Johan; Lagerlund, Olof et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 4790-4793, 2009

• DOI for Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors

Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor

Sköld, Christian; Nikiforovich, Gregory; Karlén, Anders

Part of Journal of Molecular Graphics and Modelling, p. 991-1003, 2008

• DOI for Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor

Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety

Rönn, Robert; Lampa, Anna; Peterson, Shane D.; Gossas, Thomas et al.

Part of Bioorganic & Medicinal Chemistry, p. 2955-2967, 2008

• DOI for Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety

Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening

Jacobsson, Micael; Gäredal, Magnus; Schultz, Johan; Karlén, Anders

Part of Journal of Medicinal Chemistry, p. 2777-2786, 2008

• DOI for Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening

β-Amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors

Nurbo, Johanna; Peterson, Shane D.; Dahl, Göran; Danielson, U. Helena et al.

Part of Bioorganic & Medicinal Chemistry, p. 5590-5605, 2008

• DOI for β-Amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors

Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery

Nordqvist, Anneli; Nilsson, Mikael T.; Röttger, Svenja; Odell, Luke R. et al.

Part of Bioorganic & Medicinal Chemistry, p. 5501-5513, 2008

• DOI for Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery
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Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering?: An investigation of the advantages and pitfalls of post-filtering

Muthas, Daniel; Sabnis, Yogesh A; Lundborg, Magnus; Karlén, Anders

Part of Journal of Molecular Graphics and Modelling, p. 1237-1251, 2008

• DOI for Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering?: An investigation of the advantages and pitfalls of post-filtering

Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2

Andersson, Hanna; Demaegdt, Heidi; Vauquelin, Georges; Lindeberg, Gunnar et al.

Part of Bioorganic & Medicinal Chemistry, p. 6924-6935, 2008

• DOI for Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2

Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase

Nurbo, Johanna; Roos, Annette K; Muthas, Daniel; Wahlström, Erik et al.

Part of Journal of Peptide Science, p. 822-832, 2007

• DOI for Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

Luzhkov, Victor B.; Selisko, Barbara; Nordqvist, Anneli; Peyrane, Frédéric et al.

Part of Bioorganic & Medicinal Chemistry, p. 7795-7802, 2007

• DOI for Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor

Axén, Andreas; Andersson, Hanna; Lindeberg, Gunnar; Rönnholm, Harriet et al.

Part of Journal of Peptide Science, p. 434-444, 2007

• DOI for Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor

Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors

Sköld, Christian; Karlén, Anders

Part of Journal of Molecular Graphics and Modelling, p. 145-153, 2007

• DOI for Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors

Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Georgsson, Jennie; Sköld, Christian; Botros, Milad; Lindeberg, Gunnar et al.

Part of Journal of Medicinal Chemistry, p. 1711-1715, 2007

• DOI for Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

Lagerlund, Olof; Odell, Luke R.; Mowbray, Sherry L.; Nilsson, Mikael T. et al.

Part of Combinatorial chemistry & high throughput screening, p. 783-789, 2007

• DOI for Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

Selective angiotensin II AT(2) receptor agonists devoid of the imidazole ring system

Murugaiah, A. M. S.; Wallinder, Chalotta; Mahalingam, A. K.; Wu, Xiongyu et al.

Part of Bioorganic & Medicinal Chemistry, p. 7166-7183, 2007

• DOI for Selective angiotensin II AT(2) receptor agonists devoid of the imidazole ring system

Focused hierarchical design of peptide libraries - follow the lead

Muthas, Daniel; Lek, Per M.; Nurbo, Johanna; Karlén, Anders et al.

Part of Journal of Chemometrics, p. 486-495, 2007

• DOI for Focused hierarchical design of peptide libraries - follow the lead

Phenylglycine as a Novel P2 Scaffold in Hepatitis C Virus NS3 Protease Inhibitors

Örtqvist, Pernilla; Peterson, Shane D.; Åkerblom, Eva; Gossas, Thomas et al.

Part of Bioorganic & Medicinal Chemistry, p. 1448-1474, 2007

• DOI for Phenylglycine as a Novel P2 Scaffold in Hepatitis C Virus NS3 Protease Inhibitors

Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach

Sunnerheim, Kerstin; Nordqvist, Anneli; Nordlander, Göran; Borg-Karlson, Anna-Karin et al.

Part of Journal of Agricultural and Food Chemistry, p. 9365-9372, 2007

• DOI for Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach

Improved CoMFA modeling by optimization of settings.

Peterson, Shane D; Schaal, Wesley; Karlén, Anders

Part of J Chem Inf Model, p. 355-64, 2006

Short pseudopeptides containing turn scaffolds with high AT(2) receptor affinity

Georgsson, Jennie; Rosenström, Ulrika; Wallinder, Charlotta; Beaudry, Hélène et al.

Part of Bioorganic & Medicinal Chemistry, p. 5963-5972, 2006

• DOI for Short pseudopeptides containing turn scaffolds with high AT(2) receptor affinity

Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT(1) and AT(2) receptors

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Part of Journal of Medicinal Chemistry, p. 6133-6137, 2006

• DOI for Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT(1) and AT(2) receptors

A New Structural Theme in C2-Symmetric HIV-1 Protease Inhibitors: ortho-Substituted P1/P1’ Side Chains

Wannberg, Johan; Sabnis, Yogesh A.; Vrang, Lotta; Samuelsson, Bertil et al.

Part of Bioorganic & Medicinal Chemistry, p. 5303-5315, 2006

Selective angiotensin II AT(2) receptor agonists: Arylbenzylimidazole structure-activity relationships

Wu, Xiongyu; Wan, Yiqian; Mahalingam, A. K.; Murugaiah, A. M. S. et al.

Part of Journal of Medicinal Chemistry, p. 7160-7168, 2006

• DOI for Selective angiotensin II AT(2) receptor agonists: Arylbenzylimidazole structure-activity relationships

Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies.

Skold, Christian; Winiwarter, Susanne; Wernevik, Johan; Bergstrom, Fredrik et al.

Part of J Med Chem, p. 6660-71, 2006

Fast and selective synthesis of novel cyclic sulfamide HIV-1 purchase inhibitors under controlled microwave heating

Gold, H; Ax, A; Vrang, L; Samuelsson, B et al.

Part of Tetrahedron, p. 4671-4675, 2006

Ligand bias of scoring functions in structure-based virtual screening.

Jacobsson, Micael; Karlén, Anders

Part of J Chem Inf Model, p. 1334-43, 2006

Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2' to P1/P1'.

Ax, Anna; Schaal, Wesley; Vrang, Lotta; Samuelsson, Bertil et al.

Part of Bioorg Med Chem, p. 755-64, 2005

New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

Rosenström, Ulrika; Sköld, Christian; Plouffe, Bianca; Beaudry, Hélène et al.

Part of Journal of Medicinal Chemistry, p. 4009-4024, 2005

• DOI for New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

A new tool in peptide engineering: a photoswitchable stilbene-type beta-hairpin mimetic.

Erdélyi, Máté; Karlén, Anders; Gogoll, Adolf

Part of Chemistry, p. 403-12, 2005

Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II.

Muthas, Daniel; Nötteberg, Daniel; Sabnis, Yogesh A; Hamelink, Elizabeth et al.

Part of Bioorg Med Chem, p. 5371-90, 2005

A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic replacing the Amino Acid Residues 4-5 of Angiotensin II

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Part of Journal of Medicinal Chemistry, p. 859-870, 2004

• DOI for A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic replacing the Amino Acid Residues 4-5 of Angiotensin II

Synthesis and AT2 receptor-binding properties of angiotensin II analogues

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Part of Journal of Peptide Research, p. 194-201, 2004

• DOI for Synthesis and AT2 receptor-binding properties of angiotensin II analogues

First Reported Nonpeptide AT1 Receptor Agonist (L-162,313) Acts as an AT2 Receptor Agonist in Vivo

Wan, Yigian; Wallinder, Charlotta; Johansson, Berndt; Holm, Mathias et al.

Part of Journal of Medicinal Chemistry, p. 1536-1546, 2004

• DOI for First Reported Nonpeptide AT1 Receptor Agonist (L-162,313) Acts as an AT2 Receptor Agonist in Vivo

Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site.

Roos, Annette K; Andersson, C Evalena; Bergfors, Terese; Jacobsson, Micael et al.

Part of J Mol Biol, p. 799-809, 2004

AT2-selective angiotensin II analogues containing tyrosine-functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics.

Johannesson, Petra; Erdelyi, Mate; Lindeberg, Gunnar; Frändberg, Per-Anders et al.

Part of J Med Chem, p. 6009-19, 2004

Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques.

Afzelius, Lovisa; Raubacher, Florian; Karlen, Anders; Jørgensen, Flemming Steen et al.

Part of Drug Metab Dispos, p. 1218-29, 2004

Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors.

Afzelius, Lovisa; Zamora, Ismael; Masimirembwa, Collen M; Karlen, Anders et al.

Part of J Med Chem, p. 907-14, 2004

Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor

Johannesson, Petra; Lindeberg, Gunnar; Johansson, Anja; Nikiforovich, Gregory V et al.

Part of Journal of Medicinal Chemistry, p. 1767-1777, 2002

• DOI for Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor

Effects of cholesterol and model transmembrane proteins on drugpartitioning into lipid bilayers as analysed by immobilized-liposomechromatography.

Lagerquist, C; Beigi, F; Karlen, A; Lennernas, H et al.

Part of J Pharm Pharmacol, p. 1477, 2001

Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen

Hämäläinen, Markku D.; Markgren, Per-Olof; Schaal, Wesley; Karlén, Anders et al.

Part of Journal of Biomolecular Screening, p. 353-359, 2000

• DOI for Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen

Angiotensin II analogues encompassing 5,9-and 5,10-fused thiabicycloalkane tripeptide mimetics

Johannesson, Petra; Lindeberg, Gunnar; Tong, Weimin; Gogoll, Adolf et al.

Part of Journal of Medicinal Chemistry, p. 4524-4537, 1999

• DOI for Angiotensin II analogues encompassing 5,9-and 5,10-fused thiabicycloalkane tripeptide mimetics

Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains

Hultén, Johan; Andersson, Hans O.; Schaal, Wesley; Danielson, U. Helena et al.

Part of Journal of Medicinal Chemistry, p. 4054-4061, 1999

• DOI for Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains

Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor

Bäckbro, Kristina; Löwgren, Seved; Österlund, Katrin; Atepo, Johnson et al.

Part of Journal of Medicinal Chemistry, p. 898-902, 1997

• DOI for Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor

Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol

Niklasson, Gunilla; Kvarnström, Ingemar; Classon, Björn; Samuelsson, Bertil et al.

Part of Journal of carbohydrate chemistry, p. 555-569, 1996

• DOI for Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol

Innovative roadmaps for sustainable antimicrobial resistance interventions

Gasperini, Gianmarco; Rossi Paccani, Silvia; O'Dwyer, Karen; Aanensen, David M. et al.

Part of Science Translational Medicine, 2026

• DOI for Innovative roadmaps for sustainable antimicrobial resistance interventions

Towards the sustainable discovery and development of new antibiotics

Miethke, Marcus; Pieroni, Marco; Weber, Tilmann; Brönstrup, Mark et al.

Part of Nature Reviews Chemistry, p. 726-749, 2021

• DOI for Towards the sustainable discovery and development of new antibiotics

The global preclinical antibacterial pipeline

Theuretzbacher, Ursula; Outterson, Kevin; Engel, Aleks; Karlen, Anders

Part of Nature Reviews Microbiology, p. 275-285, 2020

• DOI for The global preclinical antibacterial pipeline

The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance

Kostyanev, T.; Bonten, M. J. M.; O'Brien, S.; Steel, H. et al.

Part of Journal of Antimicrobial Chemotherapy, p. 290-295, 2016

• DOI for The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance

Discovery and preclinical development of new antibiotics

Hughes, Diarmaid; Karlén, Anders

Part of Upsala Journal of Medical Sciences, p. 162-169, 2014

• DOI for Discovery and preclinical development of new antibiotics

Identification and Optimization of an Acylguanidine-Based Antibacterial Chemotype

Andersson, Ottilia; Lindahl, Otto; Cao, Sha; Huseby, Douglas L et al.