Mats Larhed
Adviser for innovation at University Board and Chief Officers; Advisers to the Vice-Chancellor
- Mobile phone:
- +46 70 493 53 83
- E-mail:
- mats.larhed@ilk.uu.se
Professor at Department of Medicinal Chemistry; Preparative Medicinal Chemistry
- Mobile phone:
- +46 70 493 53 83
- E-mail:
- mats.larhed@ilk.uu.se
- Visiting address:
- Uppsala Biomedicinska Centrum, BMC, Husarg. 3
- Postal address:
- Box 574
751 23 UPPSALA
- CV:
- Download CV
Short presentation
Mats Larhed was born in Västerås, Sweden, on August 21, 1964. He graduated in 1991 with a Master of Science in Pharmacy. His doctoral studies in Organic Pharmaceutical Chemistry were accomplished in 1997. He became Senior Lecturer in 2001, was appointed full Professor in Combinatorial Chemistry 2007, before being appointed at Uppsala University as Professor in Medicinal Chemistry in 2015. He held the position of Vice-Rector for Medicine and Pharmacy 2020–2026. For full CV, see link above.
Keywords
- antibiotics
- microwave chemistry
- flow chemistry
- angiotensin
- irap
- palladium
- pulmonary fibrosis
Biography
Mats Larhed is Professor in Medicinal Chemistry and holds at present the position as Adviser to the Vice-Chancellor at Uppsala University.
Larhed is engaged in the development of the Beijer laboratory for drug discovery. He is also member of the national SciLifeLab Board,
Larhed is interested in the development of career paths at universities and he was the Chair of the Uppsala University working group on career paths and was responsible for the approved Uppsala Universities Charter & Code Human Resources Strategy for Researchers (HRS4R) application. He has served as chair for quality assurance evaluations of the Swedish University of Agricultural Sciences (SLU) and of the University of Borås.
Larhed is member of The Royal Society of Sciences in Uppsala, The Society of Arts and Sciences of Uppsala and The Royal Swedish Academy of Engineering Sciences (IVA).
Mats Larheds teaching activities have been directed toward students in pharmacy, chemical engineering and biomedicine. He early developed web-based examinations and lectures for his chemistry courses. His web lectures have been viewed > 30 000 times. He has overseen 23 PhD students to a final doctorate as the main supervisor and is presently supervising two PostDoc students.
Larheds main research interests are: I) the discovery and development of new pharmaceutical agents for treatment of pulmonary fibrosis (IPF) and other inflammatory diseases, II) development of new chemical methodologies of importance for drug discovery.
Larhed has received a number of grants from for example the Knut and Alice Wallenberg Foundation, the Swedish Research Council and the European Commission Framework Programs as well as a couple of prestigious awards, including The Holmquist Prize. He has published more than 240 scientific articles and ten approved patents (all sold).

Publications
Selection of publications
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N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of European Journal of Medicinal Chemistry, 2024
- DOI for N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
- Download full text (pdf) of N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
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Part of International Journal of Molecular Sciences, 2024
- DOI for Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
- Download full text (pdf) of Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
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Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
Part of European Journal of Medicinal Chemistry Reports, 2024
- DOI for Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
- Download full text (pdf) of Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
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Part of International Journal of Molecular Sciences, 2024
- DOI for The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
- Download full text (pdf) of The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
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Part of Hormones and Behavior, 2024
- DOI for The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
- Download full text (pdf) of The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
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Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
Part of International Journal of Molecular Sciences, 2024
- DOI for Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
- Download full text (pdf) of Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
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Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
Part of Bioorganic & Medicinal Chemistry, 2022
- DOI for Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
- Download full text (pdf) of Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
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2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
Part of Bioorganic & Medicinal Chemistry, 2022
- DOI for 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
- Download full text (pdf) of 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
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N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands
Part of Bioorganic & Medicinal Chemistry, 2021
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From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
Part of Frontiers in Pharmacology, 2020
- DOI for From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
- Download full text (pdf) of From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
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Part of Journal of Organic Chemistry, p. 7648-7657, 2020
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Part of ChemistryOpen, p. 325-337, 2020
- DOI for Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
- Download full text (pdf) of Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
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Part of ChemistryOpen, p. 114-125, 2019
- DOI for A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
- Download full text (pdf) of A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
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Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki-Heck Coupling of Aryl Iodides
Part of Synlett, p. 82-88, 2019
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Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions
Part of Synlett, p. 141-155, 2019
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Selective Synthesis of Spirooxindoles by an Intramolecular Heck-Mizoroki Reaction
Part of Organic Letters, p. 2738-2741, 2017
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Non-peptide AT2-receptor agonists
Part of Medicinal Chemistry Reviews, 2016
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Part of Assay and drug development technologies, p. 180-193, 2016
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Part of Journal of Organic Chemistry, p. 1464-1471, 2015
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Aspartic protease inhibitors containing tertiary alcohol transition-state mimics
Part of European Journal of Medicinal Chemistry, p. 462-490, 2014
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Part of Journal of Medicinal Chemistry, p. 6444-6457, 2014
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Part of Journal of Medicinal Chemistry, p. 2724-2736, 2012
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Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications
Part of Organic Process Research & Development, p. 1053-1063, 2012
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Part of Journal of Organic Chemistry, p. 11393-11398, 2012
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Part of Organic and biomolecular chemistry, p. 2713-2729, 2012
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Part of Chemistry - A European Journal, p. 4714-4722, 2012
- DOI for Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
- Download full text (pdf) of Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
Recent publications
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Part of Results in Chemistry, 2026
- DOI for From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold
- Download full text (pdf) of From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold
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New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold
Part of Bioorganic & Medicinal Chemistry, 2026
- DOI for New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold
- Download full text (pdf) of New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold
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Part of IBRO Neuroscience Reports, p. 854-861, 2025
- DOI for The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats
- Download full text (pdf) of The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats
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Part of Neuroscience Letters, 2025
- DOI for Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures
- Download full text (pdf) of Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures
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Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations
Part of Synlett, p. 2666-2670, 2025
- DOI for Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations
- Download full text (pdf) of Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations
All publications
Articles in journal
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Part of Results in Chemistry, 2026
- DOI for From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold
- Download full text (pdf) of From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold
-
New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold
Part of Bioorganic & Medicinal Chemistry, 2026
- DOI for New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold
- Download full text (pdf) of New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold
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Part of IBRO Neuroscience Reports, p. 854-861, 2025
- DOI for The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats
- Download full text (pdf) of The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats
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Part of Neuroscience Letters, 2025
- DOI for Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures
- Download full text (pdf) of Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures
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Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations
Part of Synlett, p. 2666-2670, 2025
- DOI for Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations
- Download full text (pdf) of Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations
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Part of RSC Medicinal chemistry, p. 5059-5069, 2025
- DOI for Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation
- Download full text (pdf) of Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation
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Part of Synlett, p. 2009-2013, 2025
- DOI for A Diastereoselective Mizoroki-Heck Reaction for Synthesis of Spirooxindole-Based Nonnatural Amino Acids Using a Boc-Protected Amine Chiral Auxiliary
- Download full text (pdf) of A Diastereoselective Mizoroki-Heck Reaction for Synthesis of Spirooxindole-Based Nonnatural Amino Acids Using a Boc-Protected Amine Chiral Auxiliary
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N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of European Journal of Medicinal Chemistry, 2024
- DOI for N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
- Download full text (pdf) of N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
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Part of International Journal of Molecular Sciences, 2024
- DOI for Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
- Download full text (pdf) of Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
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Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
Part of European Journal of Medicinal Chemistry Reports, 2024
- DOI for Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
- Download full text (pdf) of Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
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Part of International Journal of Molecular Sciences, 2024
- DOI for The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
- Download full text (pdf) of The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
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Part of Hormones and Behavior, 2024
- DOI for The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
- Download full text (pdf) of The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
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Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
Part of International Journal of Molecular Sciences, 2024
- DOI for Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
- Download full text (pdf) of Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
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Two-chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles
Part of Journal of Organic Chemistry, p. 12978-12985, 2023
- DOI for Two-chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles
- Download full text (pdf) of Two-chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles
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Part of Current Issues in Molecular Biology, p. 5000-5012, 2022
- DOI for Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures
- Download full text (pdf) of Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures
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Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
Part of Bioorganic & Medicinal Chemistry, 2022
- DOI for Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
- Download full text (pdf) of Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
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2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
Part of Bioorganic & Medicinal Chemistry, 2022
- DOI for 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
- Download full text (pdf) of 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
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Part of ACS - Infectious Diseases, p. 482-498, 2022
- DOI for Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
- Download full text (pdf) of Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
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Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations
Part of ACS Omega, 2022
- DOI for Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations
- Download full text (pdf) of Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations
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N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands
Part of Bioorganic & Medicinal Chemistry, 2021
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18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand
Part of European Journal of Pharmaceutical Sciences, 2021
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Part of ACS Medicinal Chemistry Letters, p. 1429-1434, 2020
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Part of Pharmaceutics, 2020
- DOI for Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model
- Download full text (pdf) of Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model
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Part of Journal of Organic Chemistry, p. 7648-7657, 2020
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Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)
Part of RSC Medicinal chemistry, p. 234-244, 2020
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Part of ChemistryOpen, p. 325-337, 2020
- DOI for Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
- Download full text (pdf) of Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
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Part of European Journal of Pharmacology, 2020
- DOI for Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages
- Download full text (pdf) of Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages
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Part of Pharmaceutics, 2019
- DOI for Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer
- Download full text (pdf) of Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer
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Part of ChemistryOpen, p. 114-125, 2019
- DOI for A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
- Download full text (pdf) of A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
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Part of Nuclear Medicine and Biology, p. 1-10, 2019
- DOI for Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
- Download full text (pdf) of Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
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Part of Cancers, 2019
- DOI for Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer
- Download full text (pdf) of Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer
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Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki-Heck Coupling of Aryl Iodides
Part of Synlett, p. 82-88, 2019
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Part of International Journal of Cancer, p. 3347-3358, 2019
- DOI for Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26
- Download full text (pdf) of Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26
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Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions
Part of Synlett, p. 141-155, 2019
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Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides
Part of ACS Omega, p. 4509-4521, 2018
- DOI for Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides
- Download full text (pdf) of Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides
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Part of Bioorganic & Medicinal Chemistry Letters, p. 519-522, 2018
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Lignin depolymerization to monophenolic compounds in a flow-through system
Part of Green Chemistry, p. 5767-5771, 2017
- DOI for Lignin depolymerization to monophenolic compounds in a flow-through system
- Download full text (pdf) of Lignin depolymerization to monophenolic compounds in a flow-through system
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Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation
Part of Molecules, 2017
- DOI for Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation
- Download full text (pdf) of Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation
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Part of ChemistryOpen, p. 620-628, 2017
- DOI for Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide
- Download full text (pdf) of Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide
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Part of Organic Process Research & Development, p. 947-955, 2017
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Part of Contrast Media & Molecular Imaging, 2017
- DOI for High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
- Download full text (pdf) of High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
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Part of Bioorganic & Medicinal Chemistry, p. 5095-5106, 2017
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Palladium(0)-Catalyzed Carbonylative One-Pot Synthesis of N-Acylguanidines
Part of Journal of Organic Chemistry, p. 12520-12529, 2017
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Part of Organic Letters, p. 1602-1605, 2017
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Route to 3-Amidino Indoles via Pd(II)-Catalyzed C-H Bond Activation
Part of Organic Letters, p. 4066-4069, 2017
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Selective Synthesis of Spirooxindoles by an Intramolecular Heck-Mizoroki Reaction
Part of Organic Letters, p. 2738-2741, 2017
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Part of ChemistryOpen, p. 566-573, 2016
- DOI for Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO
- Download full text (pdf) of Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO
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Part of Molecular Pharmacology, p. 413-424, 2016
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Part of ChemistryOpen, p. 566-573, 2016
- DOI for Synthesis of 11C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [11C]CO
- Download full text (pdf) of Synthesis of 11C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [11C]CO
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Part of ACS Chemical Neuroscience, p. 1383-1392, 2016
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Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26.
Part of International journal of oncology, p. 2124-2134, 2016
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Part of Assay and drug development technologies, p. 180-193, 2016
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Rapid and straightforward transesterification of sulfonyl carbamates
Part of Tetrahedron Letters, p. 1476-1478, 2016
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Part of Organic Process Research & Development, p. 440-445, 2016
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Microwave Heated Continuous Flow Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones
Part of Organic Process Research & Development, p. 2005-2011, 2016
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Synthesis of enantiopure angiotensin II type 2 receptor [AT(2)R] antagonist EMA401
Part of Tetrahedron, p. 6881-6887, 2015
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Part of Journal of labelled compounds & radiopharmaceuticals, 2015
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Influence of chelators on targeting properties of In-111 and Ga-68 labeled GRPR antagonist
Part of Journal of labelled compounds & radiopharmaceuticals, 2015
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Development of radiocobalt-labeled GRPR antagonist NOTA-PEG2-RM26.
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015
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N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase
Part of Bioorganic & Medicinal Chemistry Letters, p. 3017-3023, 2015
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3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1
Part of Bioorganic & Medicinal Chemistry Letters, p. 3024-3029, 2015
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Part of Nuclear Medicine and Biology, p. 446-454, 2015
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Part of Journal of Chemical Information and Modeling, p. 1984-1993, 2015
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Part of Chemistry - A European Journal, p. 17601-17604, 2015
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Part of ChemistryOpen, p. 342-362, 2015
- DOI for Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents
- Download full text (pdf) of Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents
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Part of ChemistryOpen, p. 174-182, 2015
- DOI for Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity
- Download full text (pdf) of Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity
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Part of Journal of Organic Chemistry, p. 1464-1471, 2015
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Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides
Part of European Journal of Organic Chemistry, p. 7069-7074, 2015
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Part of Molecules, p. 10455-10472, 2014
- DOI for The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin
- Download full text (pdf) of The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin
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Continuous flow chemistry with a non-resonant microwave applicator
Part of Abstracts of Papers of the American Chemical Society, 2014
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Part of Abstracts of Papers of the American Chemical Society, 2014
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Continuous flow chemistry utilizing silicon carbide (SiC) reactors
Part of Abstracts of Papers of the American Chemical Society, 2014
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Nonresonant microwave heated continuous flow synthesis in medicinal chemistry
Part of Abstracts of Papers of the American Chemical Society, 2014
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Synthesis and evaluation of isoleucine derived angiotensin II AT(2) receptor ligands
Part of Bioorganic & Medicinal Chemistry Letters, p. 476-479, 2014
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Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors
Part of Organic Process Research & Development, p. 1582-1588, 2014
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Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014
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Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides
Part of ChemistryOpen, p. 256-263, 2014
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Part of Organic Process Research & Development, p. 1413-1418, 2014
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Part of Journal of Medicinal Chemistry, p. 6444-6457, 2014
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Part of Journal of labelled compounds & radiopharmaceuticals, p. 525-532, 2014
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N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands
Part of ChemistryOpen, p. 65-75, 2014
- DOI for N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands
- Download full text (pdf) of N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands
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11C-Labeling of a Potent Hydroxyethylamine BACE-1 Inhibitor and Evaluation in vitro and in vivo
Part of Nuclear Medicine and Biology, p. 536-543, 2014
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C-11-Labeling of a potent hydroxyethylamine BACE-1 inhibitor and evaluation in vitro and in vivo
Part of Nuclear Medicine and Biology, p. 536-543, 2014
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Part of Tetrahedron Letters, p. 2376-2380, 2014
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Part of Journal of Organic Chemistry, p. 12018-12032, 2014
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Part of Advanced Synthesis and Catalysis, p. 870-878, 2014
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Influence of chelators on biodistribution and targeting properties of GRPR antagonist
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014
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Part of Journal of Medicinal Chemistry, p. 2690-2694, 2013
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Part of Tetrahedron Letters, p. 6912-6915, 2013
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Part of PLOS ONE, 2013
- DOI for In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging
- Download full text (pdf) of In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging
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Part of Journal of Organic Chemistry, p. 12251-12256, 2013
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Design and Synthesis of P1-P3 Macrocyclic Tertiary-Alcohol-Comprising HIV-1 Protease Inhibitors
Part of Journal of Medicinal Chemistry, p. 8999-9007, 2013
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Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013
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Temperature measurements with two different IR sensors in a continuous-flow microwave heated system
Part of Beilstein Journal of Organic Chemistry, p. 2079-2087, 2013
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Part of Chemistry - A European Journal, p. 13803-13810, 2013
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Part of Bioconjugate chemistry, p. 1144-1153, 2013
- DOI for Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging
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Part of Journal of Organic Chemistry, p. 4184-4189, 2013
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(AlF)-F-18-labelling of NOTA-P2-RM26 and its evaluation as a PET ligand for GRPR/BB2
Part of Journal of labelled compounds & radiopharmaceuticals, 2013
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Synthesis of antimalarial compounds fosmidomycin and FR900098 through N- or P-alkylation reactions
Part of Tetrahedron, p. 1183-1188, 2013
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Part of Organometallics, p. 490-497, 2013
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DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
Part of Journal of Medicinal Chemistry, p. 6190-6199, 2013
- DOI for DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
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Part of Journal of labelled compounds & radiopharmaceuticals, 2013
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Part of European Journal of Organic Chemistry, p. 4729-4733, 2013
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Part of Journal of Medicinal Chemistry, p. 2724-2736, 2012
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Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications
Part of Organic Process Research & Development, p. 1053-1063, 2012
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Part of MedChemComm, p. 620-626, 2012
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Molybdenum Hexacarbonyl Mediated CO Gas-Free Carbonylative Reactions
Part of Synlett, p. 685-698, 2012
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Part of Journal of Organic Chemistry, p. 11393-11398, 2012
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Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates
Part of Organic Letters, p. 2394-2397, 2012
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Part of ChemistryOpen, p. 140-146, 2012
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Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012
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Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012
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A non-resonant microwave applicator fully dedicated to continuous flow chemistry
Part of Chimica oggi, p. 14-16, 2012
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Synthesis of functionalized furopyrazines as restricted dipeptidomimetics
Part of Tetrahedron, p. 3019-3029, 2012
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Part of Organic and biomolecular chemistry, p. 2713-2729, 2012
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Part of Chemistry - A European Journal, p. 4714-4722, 2012
- DOI for Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
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Part of ChemistryOpen, p. 49-56, 2012
- DOI for Development of Stereocontrolled Palladium(II)-Catalyzed Domino Heck/Suzuki β, α-Diarylation Reactions with Chelating Vinyl Ethers and Arylboronic Acids
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Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
Part of Journal of Medicinal Chemistry, p. 2894-2898, 2012
- DOI for Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
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Part of Journal of Medicinal Chemistry, p. 4964-4976, 2011
- DOI for Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase
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Part of ACS Catalysis, p. 1455-1459, 2011
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Part of Journal of Pharmaceutical Sciences, p. 3763-3772, 2011
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Part of Bioorganic & Medicinal Chemistry Letters, p. 5403-5407, 2011
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Part of MedChemComm, p. 701-709, 2011
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Part of Journal of Organic Chemistry, p. 2433-2438, 2011
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Part of Bioorganic & Medicinal Chemistry, p. 145-155, 2011
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Part of Journal of Organic Chemistry, p. 978-981, 2011
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Non-peptide AT2-receptor agonists
Part of Current opinion in pharmacology (Print), p. 187-192, 2011
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Richard F. Heck: Nobel Laureate in Chemistry
Part of Les Prix Nobel, p. 133-138, 2011
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Part of Journal of Organic Chemistry, p. 8986-8998, 2011
- DOI for Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors
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Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones
Part of Bioorganic & Medicinal Chemistry, p. 6512-6525, 2010
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Hepatitis C protease inhibitors based on 2(1H)-pyrazinones
Part of Abstracts of Papers of the American Chemical Society, 2010
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Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors
Part of Tetrahedron, p. 4049-4056, 2010
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Part of Angewandte Chemie International Edition, p. 7733-7737, 2010
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Part of Journal of Medicinal Chemistry, p. 607-615, 2010
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Synthesis and evaluation of a 11C-labelled angiotensin II AT2 receptor ligand
Part of Journal of labelled compounds & radiopharmaceuticals, p. 616-624, 2010
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Continuous Flow Palladium(II): Catalyzed Oxidative Heck Reactions with Arylboronic Acids
Part of European Journal of Organic Chemistry, p. 2270-2274, 2010
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Part of Organic and biomolecular chemistry, p. 2809-2815, 2009
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Part of Journal of Molecular Biology, p. 504-513, 2009
- DOI for Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors
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Part of Chemical Communications, p. 7587-7589, 2009
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Part of Bioorganic & Medicinal Chemistry Letters, p. 4790-4793, 2009
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Part of Bioorganic & Medicinal Chemistry, p. 5933-5949, 2009
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Part of Bioorganic & Medicinal Chemistry Letters, p. 4711-4714, 2009
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Synthesis and evaluation of a new class of tertiary alcohol based BACE-1 inhibitors
Part of Tetrahedron, p. 10047-10059, 2009
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Part of Tetrahedron, p. 7646-7652, 2009
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Microwave-assisted palladium(II)-catalyzed Heck reactions
Part of Chimica oggi, p. 11-14, 2009
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Part of Chemistry - A European Journal, p. 4630-4636, 2009
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Part of Chemistry - A European Journal, p. 13069-13074, 2009
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Part of Tetrahedron, p. 8746-8751, 2008
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Microwave-promoted aminocarbonylation of aryl triflates using Mo(CO)6 as a solid CO source
Part of Tetrahedron Letters, p. 6115-6118, 2008
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Part of Tetrahedron Letters, p. 5625-5628, 2008
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Part of Bioorganic & Medicinal Chemistry, p. 5501-5513, 2008
- DOI for Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery
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Part of Journal of Medicinal Chemistry, p. 5125-9, 2008
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Part of Journal of Medicinal Chemistry, p. 1053-1057, 2008
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Fast, acid-free, and selective lactamization of lactones in ionic liquids
Part of Journal of Organic Chemistry, p. 8627-30, 2008
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Part of Tetrahedron, p. 1120-1126, 2008
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Part of Tetrahedron, p. 1808-1812, 2008
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Part of Organic and biomolecular chemistry, p. 674-676, 2008
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Part of Journal of Organic Chemistry, p. 5851-5854, 2007
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Part of Journal of Organic Chemistry, p. 7957-7962, 2007
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Part of Journal of Medicinal Chemistry, p. 1711-1715, 2007
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Part of Combinatorial chemistry & high throughput screening, p. 783-789, 2007
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Highly regioselective internal heck arylation of hydroxyalkyl vinyl ethers by aryl halides in water
Part of Journal of Organic Chemistry, p. 6390-6396, 2007
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Microwave-Enhanced Copper-Catalyzed N-Arylation of Free and Protected Amino Acids in Water
Part of Journal of combinatorial chemistry, p. 204-209, 2007
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Part of Journal of Organic Chemistry, p. 8779-8786, 2006
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Part of Organic and biomolecular chemistry, p. 3040-3043, 2006
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Part of Journal of Medicinal Chemistry, p. 1828-1832, 2006
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Part of Bioorganic & Medicinal Chemistry, p. 5303-5315, 2006
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Part of Journal of Organic Chemistry, p. 1265-1268, 2006
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Open-air oxidative Heck reactions at room temperature
Part of Green Chemistry, p. 338-343, 2006
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Part of Journal of Organic Chemistry, p. 3896-3903, 2006
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Microwave-Promoted Aminocarbonylation of Aryl Iodides, Aryl Bromides, and Aryl Chlorides in Water
Part of Organometallics, p. 1434-1439, 2006
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Part of Jounal of Medicinal Chemistry, p. 1828-1832, 2006
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Part of J Org Chem, p. 3896-903, 2006
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Hydroxylamine as an ammonia equivalent in microwave-enhanced aminocarbonylations
Part of Tetrahedron, p. 4665-4670, 2006
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Microwave-promoted aminocarbonylation of aryl iodides, aryl bromides and aryl chlorides in water.
Part of Organometallics, p. 1434-1832, 2006
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Microwave-assisted and metal-catalyzed coupling reactions
Part of Top. Curr. Chem., p. 103-144, 2006
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Microwave-accelerated synthesis of protease inhibitors
Part of Top. Curr. Chem., p. 3040-3043, 2006
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Part of Tetrahedron, p. 4671-4675, 2006
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Part of Synlett, p. 1596-1600, 2005
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Microwave-Enhanced and Metal-Catalyzed Functionalizations of the 4-Aryl-Dihydropyrimidone Template
Part of Journal of combinatorial chemistry, p. 574-583, 2005
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Super fast cobalt carbonyl-mediated synthesis of ureas
Part of Tetrahedron Letters, p. 3335-3339, 2005
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A One-Pot Isomerization-Arylation of 2,3-Epoxycyclohexanone under Controlled Microwave Heating
Part of The Journal of Organic Chemistry, p. 4720-4725, 2005
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Part of The Journal of Organic Chemistry, p. 3094-3098, 2005
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Masked 3-Aminoindan-1-ones by a Palladium-Catalyzed Three-Component Annulation Reaction
Part of Journal of Organic Chemistry, p. 938-942, 2005
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Microwave-enhanced aminocarbonylations in water.
Part of Org Lett, p. 3327-9, 2005
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Part of J Org Chem, p. 3094-8, 2005
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Microwave-enhanced carbonylative generation of indanones and 3-acylaminoindanones.
Part of J Org Chem, p. 346-9, 2005
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Part of Angew Chem Int Ed Engl, p. 7666-9, 2005
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Part of J Comb Chem, p. 4-6, 2005
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Super fast cobalt carbonyl-mediated synthesis of ureas compounds
Part of Tetrahedron Letters, p. 3335-3339, 2005
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Masked 3-aminoindan-1-ones by a palladium-catalyzed three-component annulation reaction.
Part of J Org Chem, p. 938-42, 2005
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A one-pot isomerization-arylation of 2,3-epoxycyclohexanone under controlled microwave heating.
Part of J Org Chem, p. 4720-5, 2005
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Part of Chemical Communications, p. 218-9, 2004
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Part of Chemical Communications, p. 790-791, 2004
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Part of Synlett, p. 2335-2338, 2004
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Part of The Journal of Organic Chemistry, p. 3345-3349, 2004
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Part of Curr Opin Drug Discov Devel, p. 417-27, 2004
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Part of Chem Commun (Camb), p. 790-1, 2004
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Part of J Org Chem, p. 5212-8, 2004
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Part of Synlett, p. 2335-2338, 2004
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Terminal Heck vinylations of chelating vinyl ethers.
Part of Advanced Synthesis & Catalysis, p. 1773-1781, 2004
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Part of J Org Chem, p. 3345-9, 2004
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High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II
Part of Journal of combinatorial chemistry, p. 456-464, 2003
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Arylboronic acids as versatile coupling partners in fast microwave promoted oxidative Heck chemistry
Part of Molecular diversity, p. 97-106, 2003
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Part of Journal of Organic Chemistry, p. 5750-5753, 2003
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Part of Journal of Combinatorial Chemistry, p. 350-352, 2003
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Part of Organic Letters, p. 4875-4878, 2003
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Microwave-assisted high-speed PCR
Part of European Journal of Pharmaceutical Sciences, p. 129-132, 2003
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A Rapid Microwave Protocol for Heck Vinylation of Aryl Chlorides under Air
Part of Molecular Diversity, p. 107-114, 2003
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A New Highly Asymmetric Chelation-Controlled Heck Arylation
Part of Journal of the American Chemical Society, p. 3430-3431, 2003
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A rapid microwave protocol for Heck vinylation of aryl chlorides under air.
Part of Mol Divers, p. 107, 2003
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Part of Synthesis, p. 1611-1614, 2002
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High-Speed Heck Reactions in Ionic Liquid with Controlled Microwave Heating
Part of J. Org. Chem., p. 6243-6246, 2002
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Protected Indanones by a Heck-Aldol Annulation Reaction
Part of Journal of Organic Chemistry, p. 5854-5856, 2002
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Fast Synthesis of Aryl Triflates with Controlled Microwave Heating
Part of Organic Letters, p. 1231-1233, 2002
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Part of J. Org. Chem., p. 4340-4343, 2001
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Part of Journal of the American Chemical Society, p. 8217-8225, 2001
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Part of J. Org. Chem., p. 4537-4542, 2000
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Part of J. Org. Chem.
Articles, review/survey
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From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
Part of Frontiers in Pharmacology, 2020
- DOI for From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
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Aspartic protease inhibitors containing tertiary alcohol transition-state mimics
Part of European Journal of Medicinal Chemistry, p. 462-490, 2014
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Syntheses of new tuberculosis inhibitors promoted by microwave irradiation
Part of Upsala Journal of Medical Sciences, p. 181-191, 2014
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Part of QSAR & combinatorial science (Print), p. 51-68, 2007
Chapters in book
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Microwave-assisted synthesis of anti-tuberculosis, HIV and hepatitis C agents
Part of Microwaves in Drug Discovery and Development, p. 34-54, Future Medicine, 2014
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Microwave-Heated Transition Metal-Catalyzed Coupling Reactions
Part of Microwaves in Organic Synthesis, p. 607-672, Wiley-VCH Verlagsgesellschaft, 2012
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Microwave-Assisted Transition Metal-Catalyzed Asymmetric Synthesis
Part of Catalytic Methods in Asymmetric Synthesis, p. 391-412, Wiley-Blackwell, 2011
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Microwave-accelerated homogenous catalysis in water
Part of Handbook of green chemistry, p. 79-99, Wiley-VCH Verlagsgesellschaft, 2009
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Focus on Regioselectivity and Product Outcome in Organic Synthesis
Part of The Mizoroki-Heck Reaction, p. 133-162, John Wiley & Sons, 2009
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Accelerated Chemistry: Microwave, Sonochemical, and Fluorous Phase Techniques
Part of Exploiting chemical diversity for drug discovery, p. 33-48, Royal Chemical Society, 2006
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Microwave Accelerated Metal Catalysis: Organic Transformations at Warp Speed
Part of Microwave Assisted Organic Synthesis, p. 25-43, Blackwell publishing, 2005
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Microwave-Assisted Fluorous Chemistry
Part of Handbook of Fluorous Chemistry, p. 359-365, Wiley-VCH, 2004
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Part of Catalysts for the Fine Chemical Synthesis, Vol. 3, p. 92-99, John Wiley and Sons, 2004
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Transition metal-catalysis and microwave flash-heating in organic chemistry
Part of Microwaves in Organic Synthesis, Wiley-VCH, 2002
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Scope, Mechanism and Other Fundamental Aspects of the Intermolecular Heck Reaction
Part of Handbook of Organopalladium Chemistry for Organic Synthesis, Wiley-Interscience, 2002
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Experimental Techniques in Fluorous Synthesis: A users guide
Part of Combinatorial Chemistry, p. 338-340, 2000
Conference papers
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Synthesis and initial preclinical evaluation of the CRTH2 antagonist [C-11] MK-7246
Part of Journal of Labelled Compounds and Pharmaceuticals, 2019
Manuscripts (preprints)
Other
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Non-peptide AT2-receptor agonists
Part of Medicinal Chemistry Reviews, 2016