Mats Larhed
Professor at Department of Medicinal Chemistry; Preparative Medicinal Chemistry
- Mobile phone:
- +46 70 493 53 83
- E-mail:
- mats.larhed@ilk.uu.se
- Visiting address:
- Uppsala Biomedicinska Centrum, BMC, Husarg. 3
- Postal address:
- Box 574
751 23 UPPSALA
- CV:
- Download CV
Short presentation
Mats Larhed was born in Västerås, Sweden, on August 21, 1964. He graduated in 1991 with a Master of Science in Pharmacy. His doctoral studies in Organic Pharmaceutical Chemistry were accomplished in 1997. He became Senior Lecturer in 2001, was appointed full Professor in Combinatorial Chemistry 2007, before being appointed at Uppsala University as Professor in Medicinal Chemistry in 2015. He was elected as Vice-Rector for Medicine and Pharmacy in 2020. For full CV, see link below:
Keywords
- antibiotics
- microwave chemistry
- flow chemistry
- angiotensin
- irap
- palladium
- pulmonary fibrosis
Biography
Mats Larhed is Professor in Medicinal Chemistry and holds at present the position as Vice-Rector for the Disciplinary Domain of Medicine and Pharmacy at Uppsala University.
Larhed is engaged in the development of the Beijer laboratory for drug discovery. He is also member of the national SciLifeLab Board,
Larhed is interested in the development of career paths at universities and he was the Chair of the Uppsala University working group on career paths and was responsible for the approved Uppsala Universities Charter & Code Human Resources Strategy for Researchers (HRS4R) application. He has served as chair for quality assurance evaluations of the Swedish University of Agricultural Sciences (SLU) and of the University of Borås.
Larhed is member of The Royal Society of Sciences in Uppsala, The Society of Arts and Sciences of Uppsala and The Royal Swedish Academy of Engineering Sciences (IVA).
Mats Larheds teaching activities have been directed toward students in pharmacy, chemical engineering and biomedicine. He early developed web-based examinations and lectures for his chemistry courses. His web lectures have been viewed > 30 000 times. He has overseen 22 PhD students to a final doctorate as the main supervisor and is presently supervising one PhD student and two PostDoc students.
Larheds main research interests are: I) the discovery and development of new pharmaceutical agents for treatment of pulmonary fibrosis (IPF) and other inflammatory diseases, II) development of new chemical methodologies of importance for drug discovery.
Larhed has received a number of grants from for example the Knut and Alice Wallenberg Foundation, the Swedish Research Council and the European Commission Framework Programs as well as a couple of prestigious awards, including The Holmquist Prize. He has published more than 220 scientific articles and a number of approved patents.

Publications
Selection of publications
Part of International Journal of Molecular Sciences, 2024
- DOI for Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
- Download full text (pdf) of Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
Part of European Journal of Medicinal Chemistry Reports, 2024
- DOI for Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
- Download full text (pdf) of Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of European Journal of Medicinal Chemistry, 2024
- DOI for N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
- Download full text (pdf) of N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of International Journal of Molecular Sciences, 2024
- DOI for The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
- Download full text (pdf) of The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
Part of Hormones and Behavior, 2024
- DOI for The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
- Download full text (pdf) of The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
Part of International Journal of Molecular Sciences, 2024
- DOI for Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
- Download full text (pdf) of Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
Part of Bioorganic & Medicinal Chemistry, 2022
- DOI for Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
- Download full text (pdf) of Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
Part of Bioorganic & Medicinal Chemistry, 2022
- DOI for 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
- Download full text (pdf) of 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands
Part of Bioorganic & Medicinal Chemistry, 2021
From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
Part of Frontiers in Pharmacology, 2020
- DOI for From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
- Download full text (pdf) of From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
Part of Journal of Organic Chemistry, p. 7648-7657, 2020
Part of ChemistryOpen, p. 325-337, 2020
- DOI for Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
- Download full text (pdf) of Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
Part of ChemistryOpen, p. 114-125, 2019
- DOI for A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
- Download full text (pdf) of A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki-Heck Coupling of Aryl Iodides
Part of Synlett, p. 82-88, 2019
Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions
Part of Synlett, p. 141-155, 2019
Selective Synthesis of Spirooxindoles by an Intramolecular Heck-Mizoroki Reaction
Part of Organic Letters, p. 2738-2741, 2017
Non-peptide AT2-receptor agonists
Part of Medicinal Chemistry Reviews, 2016
Part of Assay and drug development technologies, p. 180-193, 2016
Part of Journal of Organic Chemistry, p. 1464-1471, 2015
Aspartic protease inhibitors containing tertiary alcohol transition-state mimics
Part of European Journal of Medicinal Chemistry, p. 462-490, 2014
Part of Journal of Medicinal Chemistry, p. 6444-6457, 2014
Part of Journal of Medicinal Chemistry, p. 2724-2736, 2012
Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications
Part of Organic Process Research & Development, p. 1053-1063, 2012
Part of Journal of Organic Chemistry, p. 11393-11398, 2012
Part of Organic and biomolecular chemistry, p. 2713-2729, 2012
Part of Chemistry - A European Journal, p. 4714-4722, 2012
- DOI for Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
- Download full text (pdf) of Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
Recent publications
Part of International Journal of Molecular Sciences, 2024
- DOI for Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
- Download full text (pdf) of Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
Part of European Journal of Medicinal Chemistry Reports, 2024
- DOI for Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
- Download full text (pdf) of Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of European Journal of Medicinal Chemistry, 2024
- DOI for N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
- Download full text (pdf) of N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of International Journal of Molecular Sciences, 2024
- DOI for The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
- Download full text (pdf) of The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
Part of Hormones and Behavior, 2024
- DOI for The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
- Download full text (pdf) of The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
All publications
Articles in journal
Part of International Journal of Molecular Sciences, 2024
- DOI for Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
- Download full text (pdf) of Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
Part of European Journal of Medicinal Chemistry Reports, 2024
- DOI for Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
- Download full text (pdf) of Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of European Journal of Medicinal Chemistry, 2024
- DOI for N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
- Download full text (pdf) of N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of International Journal of Molecular Sciences, 2024
- DOI for The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
- Download full text (pdf) of The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
Part of Hormones and Behavior, 2024
- DOI for The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
- Download full text (pdf) of The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
Part of International Journal of Molecular Sciences, 2024
- DOI for Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
- Download full text (pdf) of Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
Two-chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles
Part of Journal of Organic Chemistry, p. 12978-12985, 2023
- DOI for Two-chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles
- Download full text (pdf) of Two-chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles
Part of Current Issues in Molecular Biology, p. 5000-5012, 2022
- DOI for Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures
- Download full text (pdf) of Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures
Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
Part of Bioorganic & Medicinal Chemistry, 2022
- DOI for Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
- Download full text (pdf) of Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
Part of Bioorganic & Medicinal Chemistry, 2022
- DOI for 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
- Download full text (pdf) of 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
Part of ACS - Infectious Diseases, p. 482-498, 2022
- DOI for Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
- Download full text (pdf) of Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations
Part of ACS Omega, 2022
- DOI for Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations
- Download full text (pdf) of Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations
N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands
Part of Bioorganic & Medicinal Chemistry, 2021
18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand
Part of European Journal of Pharmaceutical Sciences, 2021
Part of ACS Medicinal Chemistry Letters, p. 1429-1434, 2020
Part of Pharmaceutics, 2020
- DOI for Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model
- Download full text (pdf) of Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model
Part of Journal of Organic Chemistry, p. 7648-7657, 2020
Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)
Part of RSC Medicinal chemistry, p. 234-244, 2020
Part of ChemistryOpen, p. 325-337, 2020
- DOI for Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
- Download full text (pdf) of Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
Part of European Journal of Pharmacology, 2020
- DOI for Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages
- Download full text (pdf) of Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages
Part of Pharmaceutics, 2019
- DOI for Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer
- Download full text (pdf) of Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer
Part of ChemistryOpen, p. 114-125, 2019
- DOI for A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
- Download full text (pdf) of A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
Part of Nuclear Medicine and Biology, p. 1-10, 2019
- DOI for Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
- Download full text (pdf) of Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
Part of Cancers, 2019
- DOI for Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer
- Download full text (pdf) of Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer
Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki-Heck Coupling of Aryl Iodides
Part of Synlett, p. 82-88, 2019
Part of International Journal of Cancer, p. 3347-3358, 2019
- DOI for Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26
- Download full text (pdf) of Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26
Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions
Part of Synlett, p. 141-155, 2019
Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides
Part of ACS Omega, p. 4509-4521, 2018
- DOI for Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides
- Download full text (pdf) of Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides
Part of Bioorganic & Medicinal Chemistry Letters, p. 519-522, 2018
Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation
Part of Molecules, 2017
- DOI for Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation
- Download full text (pdf) of Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation
Part of ChemistryOpen, p. 620-628, 2017
- DOI for Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide
- Download full text (pdf) of Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide
Lignin depolymerization to monophenolic compounds in a flow-through system
Part of Green Chemistry, p. 5767-5771, 2017
Part of Organic Process Research & Development, p. 947-955, 2017
Part of Contrast Media & Molecular Imaging, 2017
- DOI for High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
- Download full text (pdf) of High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
Part of Bioorganic & Medicinal Chemistry, p. 5095-5106, 2017
Palladium(0)-Catalyzed Carbonylative One-Pot Synthesis of N-Acylguanidines
Part of Journal of Organic Chemistry, p. 12520-12529, 2017
Part of Organic Letters, p. 1602-1605, 2017
Route to 3-Amidino Indoles via Pd(II)-Catalyzed C-H Bond Activation
Part of Organic Letters, p. 4066-4069, 2017
Selective Synthesis of Spirooxindoles by an Intramolecular Heck-Mizoroki Reaction
Part of Organic Letters, p. 2738-2741, 2017
Part of Molecular Pharmacology, p. 413-424, 2016
Part of ChemistryOpen, p. 566-573, 2016
- DOI for Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO
- Download full text (pdf) of Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO
Part of ChemistryOpen, p. 566-573, 2016
- DOI for Synthesis of 11C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [11C]CO
- Download full text (pdf) of Synthesis of 11C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [11C]CO
Part of ACS Chemical Neuroscience, p. 1383-1392, 2016
Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26.
Part of International journal of oncology, p. 2124-2134, 2016
Part of Assay and drug development technologies, p. 180-193, 2016
Rapid and straightforward transesterification of sulfonyl carbamates
Part of Tetrahedron Letters, p. 1476-1478, 2016
Part of Organic Process Research & Development, p. 440-445, 2016
Microwave Heated Continuous Flow Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones
Part of Organic Process Research & Development, p. 2005-2011, 2016
Synthesis of enantiopure angiotensin II type 2 receptor [AT(2)R] antagonist EMA401
Part of Tetrahedron, p. 6881-6887, 2015
Part of Journal of labelled compounds & radiopharmaceuticals, 2015
Influence of chelators on targeting properties of In-111 and Ga-68 labeled GRPR antagonist
Part of Journal of labelled compounds & radiopharmaceuticals, 2015
Development of radiocobalt-labeled GRPR antagonist NOTA-PEG2-RM26.
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015
N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase
Part of Bioorganic & Medicinal Chemistry Letters, p. 3017-3023, 2015
3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1
Part of Bioorganic & Medicinal Chemistry Letters, p. 3024-3029, 2015
Part of Nuclear Medicine and Biology, p. 446-454, 2015
Part of Journal of Chemical Information and Modeling, p. 1984-1993, 2015
Part of Chemistry - A European Journal, p. 17601-17604, 2015
Part of ChemistryOpen, p. 342-362, 2015
- DOI for Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents
- Download full text (pdf) of Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents
Part of ChemistryOpen, p. 174-182, 2015
- DOI for Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity
- Download full text (pdf) of Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity
Part of Journal of Organic Chemistry, p. 1464-1471, 2015
Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides
Part of European Journal of Organic Chemistry, p. 7069-7074, 2015
Part of Molecules, p. 10455-10472, 2014
- DOI for The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin
- Download full text (pdf) of The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin
Continuous flow chemistry with a non-resonant microwave applicator
Part of Abstracts of Papers of the American Chemical Society, 2014
Part of Abstracts of Papers of the American Chemical Society, 2014
Continuous flow chemistry utilizing silicon carbide (SiC) reactors
Part of Abstracts of Papers of the American Chemical Society, 2014
Nonresonant microwave heated continuous flow synthesis in medicinal chemistry
Part of Abstracts of Papers of the American Chemical Society, 2014
Synthesis and evaluation of isoleucine derived angiotensin II AT(2) receptor ligands
Part of Bioorganic & Medicinal Chemistry Letters, p. 476-479, 2014
Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors
Part of Organic Process Research & Development, p. 1582-1588, 2014
Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014
Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides
Part of ChemistryOpen, p. 256-263, 2014
Part of Organic Process Research & Development, p. 1413-1418, 2014
Part of Journal of Medicinal Chemistry, p. 6444-6457, 2014
Part of Journal of labelled compounds & radiopharmaceuticals, p. 525-532, 2014
N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands
Part of ChemistryOpen, p. 65-75, 2014
- DOI for N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands
- Download full text (pdf) of N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands
11C-Labeling of a Potent Hydroxyethylamine BACE-1 Inhibitor and Evaluation in vitro and in vivo
Part of Nuclear Medicine and Biology, p. 536-543, 2014
C-11-Labeling of a potent hydroxyethylamine BACE-1 inhibitor and evaluation in vitro and in vivo
Part of Nuclear Medicine and Biology, p. 536-543, 2014
Part of Tetrahedron Letters, p. 2376-2380, 2014
Part of Journal of Organic Chemistry, p. 12018-12032, 2014
Part of Advanced Synthesis and Catalysis, p. 870-878, 2014
Influence of chelators on biodistribution and targeting properties of GRPR antagonist
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014
Part of Journal of Medicinal Chemistry, p. 2690-2694, 2013
Part of Tetrahedron Letters, p. 6912-6915, 2013
Part of PLOS ONE, 2013
- DOI for In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging
- Download full text (pdf) of In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging
Part of Journal of Organic Chemistry, p. 12251-12256, 2013
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013
Design and Synthesis of P1-P3 Macrocyclic Tertiary-Alcohol-Comprising HIV-1 Protease Inhibitors
Part of Journal of Medicinal Chemistry, p. 8999-9007, 2013
Temperature measurements with two different IR sensors in a continuous-flow microwave heated system
Part of Beilstein Journal of Organic Chemistry, p. 2079-2087, 2013
Part of Chemistry - A European Journal, p. 13803-13810, 2013
Part of Bioconjugate chemistry, p. 1144-1153, 2013
- DOI for Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging
- Download full text (pdf) of Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging
Part of Journal of Organic Chemistry, p. 4184-4189, 2013
(AlF)-F-18-labelling of NOTA-P2-RM26 and its evaluation as a PET ligand for GRPR/BB2
Part of Journal of labelled compounds & radiopharmaceuticals, 2013
Part of Journal of labelled compounds & radiopharmaceuticals, 2013
DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
Part of Journal of Medicinal Chemistry, p. 6190-6199, 2013
- DOI for DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
- Download full text (pdf) of DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
Part of Organometallics, p. 490-497, 2013
Synthesis of antimalarial compounds fosmidomycin and FR900098 through N- or P-alkylation reactions
Part of Tetrahedron, p. 1183-1188, 2013
Part of European Journal of Organic Chemistry, p. 4729-4733, 2013
Part of Journal of Medicinal Chemistry, p. 2724-2736, 2012
Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications
Part of Organic Process Research & Development, p. 1053-1063, 2012
Part of MedChemComm, p. 620-626, 2012
Molybdenum Hexacarbonyl Mediated CO Gas-Free Carbonylative Reactions
Part of Synlett, p. 685-698, 2012
Part of Journal of Organic Chemistry, p. 11393-11398, 2012
Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates
Part of Organic Letters, p. 2394-2397, 2012
Part of ChemistryOpen, p. 140-146, 2012
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012
A non-resonant microwave applicator fully dedicated to continuous flow chemistry
Part of Chimica oggi, p. 14-16, 2012
Synthesis of functionalized furopyrazines as restricted dipeptidomimetics
Part of Tetrahedron, p. 3019-3029, 2012
Part of ChemistryOpen, p. 49-56, 2012
- DOI for Development of Stereocontrolled Palladium(II)-Catalyzed Domino Heck/Suzuki β, α-Diarylation Reactions with Chelating Vinyl Ethers and Arylboronic Acids
- Download full text (pdf) of Development of Stereocontrolled Palladium(II)-Catalyzed Domino Heck/Suzuki β, α-Diarylation Reactions with Chelating Vinyl Ethers and Arylboronic Acids
Part of Organic and biomolecular chemistry, p. 2713-2729, 2012
Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
Part of Journal of Medicinal Chemistry, p. 2894-2898, 2012
- DOI for Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
- Download full text (pdf) of Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
Part of Chemistry - A European Journal, p. 4714-4722, 2012
- DOI for Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
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Part of Journal of Medicinal Chemistry, p. 4964-4976, 2011
- DOI for Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase
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Part of ACS Catalysis, p. 1455-1459, 2011
Part of Journal of Pharmaceutical Sciences, p. 3763-3772, 2011
Part of Journal of Organic Chemistry, p. 2433-2438, 2011
Part of MedChemComm, p. 701-709, 2011
Part of Bioorganic & Medicinal Chemistry Letters, p. 5403-5407, 2011
Part of Bioorganic & Medicinal Chemistry, p. 145-155, 2011
Richard F. Heck: Nobel Laureate in Chemistry
Part of Les Prix Nobel, p. 133-138, 2011
Non-peptide AT2-receptor agonists
Part of Current opinion in pharmacology (Print), p. 187-192, 2011
Part of Journal of Organic Chemistry, p. 978-981, 2011
Part of Journal of Organic Chemistry, p. 8986-8998, 2011
- DOI for Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors
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Hepatitis C protease inhibitors based on 2(1H)-pyrazinones
Part of Abstracts of Papers of the American Chemical Society, 2010
Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones
Part of Bioorganic & Medicinal Chemistry, p. 6512-6525, 2010
Part of Journal of Medicinal Chemistry, p. 607-615, 2010
Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors
Part of Tetrahedron, p. 4049-4056, 2010
Part of Angewandte Chemie International Edition, p. 7733-7737, 2010
Synthesis and evaluation of a 11C-labelled angiotensin II AT2 receptor ligand
Part of Journal of labelled compounds & radiopharmaceuticals, p. 616-624, 2010
Continuous Flow Palladium(II): Catalyzed Oxidative Heck Reactions with Arylboronic Acids
Part of European Journal of Organic Chemistry, p. 2270-2274, 2010
Part of Organic and biomolecular chemistry, p. 2809-2815, 2009
Part of Journal of Molecular Biology, p. 504-513, 2009
- DOI for Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors
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Part of Bioorganic & Medicinal Chemistry, p. 5933-5949, 2009
Part of Chemical Communications, p. 7587-7589, 2009
Part of Bioorganic & Medicinal Chemistry Letters, p. 4790-4793, 2009
Part of Bioorganic & Medicinal Chemistry Letters, p. 4711-4714, 2009
Synthesis and evaluation of a new class of tertiary alcohol based BACE-1 inhibitors
Part of Tetrahedron, p. 10047-10059, 2009
Part of Tetrahedron, p. 7646-7652, 2009
Microwave-assisted palladium(II)-catalyzed Heck reactions
Part of Chimica oggi, p. 11-14, 2009
Part of Chemistry - A European Journal, p. 4630-4636, 2009
Part of Chemistry - A European Journal, p. 13069-13074, 2009
Part of Journal of Medicinal Chemistry, p. 1053-1057, 2008
Part of Bioorganic & Medicinal Chemistry, p. 5501-5513, 2008
- DOI for Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery
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Part of Tetrahedron, p. 1120-1126, 2008
Part of Tetrahedron Letters, p. 5625-5628, 2008
Fast, acid-free, and selective lactamization of lactones in ionic liquids
Part of Journal of Organic Chemistry, p. 8627-30, 2008
Part of Journal of Medicinal Chemistry, p. 5125-9, 2008
Part of Tetrahedron, p. 8746-8751, 2008
Part of Organic and biomolecular chemistry, p. 674-676, 2008
Part of Tetrahedron, p. 1808-1812, 2008
Microwave-promoted aminocarbonylation of aryl triflates using Mo(CO)(6) as a solid CO source
Part of Tetrahedron Letters, p. 6115-6118, 2008
Part of Journal of Organic Chemistry, p. 5851-5854, 2007
Part of Journal of Organic Chemistry, p. 7957-7962, 2007
Part of Journal of Medicinal Chemistry, p. 1711-1715, 2007
Part of Combinatorial chemistry & high throughput screening, p. 783-789, 2007
Highly regioselective internal heck arylation of hydroxyalkyl vinyl ethers by aryl halides in water
Part of Journal of Organic Chemistry, p. 6390-6396, 2007
Microwave-Enhanced Copper-Catalyzed N-Arylation of Free and Protected Amino Acids in Water
Part of Journal of combinatorial chemistry, p. 204-209, 2007
Part of Journal of Organic Chemistry, p. 8779-8786, 2006
Part of Organic and biomolecular chemistry, p. 3040-3043, 2006
Part of Journal of Medicinal Chemistry, p. 1828-1832, 2006
Part of Journal of Organic Chemistry, p. 1265-1268, 2006
Part of Bioorganic & Medicinal Chemistry, p. 5303-5315, 2006
Open-air oxidative Heck reactions at room temperature
Part of Green Chemistry, p. 338-343, 2006
Part of Journal of Organic Chemistry, p. 3896-3903, 2006
Part of Jounal of Medicinal Chemistry, p. 1828-1832, 2006
Microwave-Promoted Aminocarbonylation of Aryl Iodides, Aryl Bromides, and Aryl Chlorides in Water
Part of Organometallics, p. 1434-1439, 2006
Microwave-promoted aminocarbonylation of aryl iodides, aryl bromides and aryl chlorides in water.
Part of Organometallics, p. 1434-1832, 2006
Hydroxylamine as an ammonia equivalent in microwave-enhanced aminocarbonylations
Part of Tetrahedron, p. 4665-4670, 2006
Microwave-assisted and metal-catalyzed coupling reactions
Part of Top. Curr. Chem., p. 103-144, 2006
Microwave-accelerated synthesis of protease inhibitors
Part of Top. Curr. Chem., p. 3040-3043, 2006
Part of Tetrahedron, p. 4671-4675, 2006
Part of J Org Chem, p. 3896-903, 2006
Part of Synlett, p. 1596-1600, 2005
Microwave-Enhanced and Metal-Catalyzed Functionalizations of the 4-Aryl-Dihydropyrimidone Template
Part of Journal of combinatorial chemistry, p. 574-583, 2005
Super fast cobalt carbonyl-mediated synthesis of ureas
Part of Tetrahedron Letters, p. 3335-3339, 2005
Masked 3-Aminoindan-1-ones by a Palladium-Catalyzed Three-Component Annulation Reaction
Part of Journal of Organic Chemistry, p. 938-942, 2005
Part of The Journal of Organic Chemistry, p. 3094-3098, 2005
A One-Pot Isomerization-Arylation of 2,3-Epoxycyclohexanone under Controlled Microwave Heating
Part of The Journal of Organic Chemistry, p. 4720-4725, 2005
Microwave-enhanced carbonylative generation of indanones and 3-acylaminoindanones.
Part of J Org Chem, p. 346-9, 2005
Microwave-enhanced aminocarbonylations in water.
Part of Org Lett, p. 3327-9, 2005
Super fast cobalt carbonyl-mediated synthesis of ureas compounds
Part of Tetrahedron Letters, p. 3335-3339, 2005
Masked 3-aminoindan-1-ones by a palladium-catalyzed three-component annulation reaction.
Part of J Org Chem, p. 938-42, 2005
A one-pot isomerization-arylation of 2,3-epoxycyclohexanone under controlled microwave heating.
Part of J Org Chem, p. 4720-5, 2005
Part of J Comb Chem, p. 4-6, 2005
Part of Angew Chem Int Ed Engl, p. 7666-9, 2005
Part of J Org Chem, p. 3094-8, 2005
Part of Chemical Communications, p. 790-791, 2004
Part of The Journal of Organic Chemistry, p. 3345-3349, 2004
Part of Synlett, p. 2335-2338, 2004
Part of Curr Opin Drug Discov Devel, p. 417-27, 2004
Part of Chem Commun (Camb), p. 218-9, 2004
Part of J Org Chem, p. 5212-8, 2004
Part of Chem Commun (Camb), p. 790-1, 2004
Part of Synlett, p. 2335-2338, 2004
Terminal Heck vinylations of chelating vinyl ethers.
Part of Advanced Synthesis & Catalysis, p. 1773-1781, 2004
Part of J Org Chem, p. 3345-9, 2004
High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II
Part of Journal of combinatorial chemistry, p. 456-464, 2003
Part of Journal of Organic Chemistry, p. 5750-5753, 2003
Arylboronic acids as versatile coupling partners in fast microwave promoted oxidative Heck chemistry
Part of Molecular diversity, p. 97-106, 2003
A New Highly Asymmetric Chelation-Controlled Heck Arylation
Part of Journal of the American Chemical Society, p. 3430-3431, 2003
Microwave-assisted high-speed PCR
Part of European Journal of Pharmaceutical Sciences, p. 129-132, 2003
Part of Journal of Combinatorial Chemistry, p. 350-352, 2003
A Rapid Microwave Protocol for Heck Vinylation of Aryl Chlorides under Air
Part of Molecular Diversity, p. 107-114, 2003
Part of Organic Letters, p. 4875-4878, 2003
A rapid microwave protocol for Heck vinylation of aryl chlorides under air.
Part of Mol Divers, p. 107, 2003
High-Speed Heck Reactions in Ionic Liquid with Controlled Microwave Heating
Part of J. Org. Chem., p. 6243-6246, 2002
Part of Synthesis, p. 1611-1614, 2002
Fast Synthesis of Aryl Triflates with Controlled Microwave Heating
Part of Organic Letters, p. 1231-1233, 2002
Protected Indanones by a Heck-Aldol Annulation Reaction
Part of Journal of Organic Chemistry, p. 5854-5856, 2002
Part of J. Org. Chem., p. 4340-4343, 2001
Part of Journal of the American Chemical Society, p. 8217-8225, 2001
Part of J. Org. Chem., p. 4537-4542, 2000
Part of J. Org. Chem.
Articles, review/survey
From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
Part of Frontiers in Pharmacology, 2020
- DOI for From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
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Aspartic protease inhibitors containing tertiary alcohol transition-state mimics
Part of European Journal of Medicinal Chemistry, p. 462-490, 2014
Syntheses of new tuberculosis inhibitors promoted by microwave irradiation
Part of Upsala Journal of Medical Sciences, p. 181-191, 2014
Part of QSAR & combinatorial science (Print), p. 51-68, 2007
Chapters in book
Microwave-assisted synthesis of anti-tuberculosis, HIV and hepatitis C agents
Part of Microwaves in Drug Discovery and Development, p. 34-54, Future Medicine, 2014
Microwave-Heated Transition Metal-Catalyzed Coupling Reactions
Part of Microwaves in Organic Synthesis, p. 607-672, Wiley-VCH Verlagsgesellschaft, 2012
Microwave-Assisted Transition Metal-Catalyzed Asymmetric Synthesis
Part of Catalytic Methods in Asymmetric Synthesis, p. 391-412, Wiley-Blackwell, 2011
Microwave-accelerated homogenous catalysis in water
Part of Handbook of green chemistry, p. 79-99, Wiley-VCH Verlagsgesellschaft, 2009
Focus on Regioselectivity and Product Outcome in Organic Synthesis
Part of The Mizoroki-Heck Reaction, p. 133-162, John Wiley & Sons, 2009
Accelerated Chemistry: Microwave, Sonochemical, and Fluorous Phase Techniques
Part of Exploiting chemical diversity for drug discovery, p. 33-48, Royal Chemical Society, 2006
Microwave Accelerated Metal Catalysis: Organic Transformations at Warp Speed
Part of Microwave Assisted Organic Synthesis, p. 25-43, Blackwell publishing, 2005
Part of Catalysts for the Fine Chemical Synthesis, Vol. 3, p. 92-99, John Wiley and Sons, 2004
Microwave-Assisted Fluorous Chemistry
Part of Handbook of Fluorous Chemistry, p. 359-365, Wiley-VCH, 2004
Transition metal-catalysis and microwave flash-heating in organic chemistry
Part of Microwaves in Organic Synthesis, Wiley-VCH, 2002
Scope, Mechanism and Other Fundamental Aspects of the Intermolecular Heck Reaction
Part of Handbook of Organopalladium Chemistry for Organic Synthesis, Wiley-Interscience, 2002
Experimental Techniques in Fluorous Synthesis: A users guide
Part of Combinatorial Chemistry, p. 338-340, 2000
Conference papers
Synthesis and initial preclinical evaluation of the CRTH2 antagonist [C-11] MK-7246
Part of Journal of Labelled Compounds and Pharmaceuticals, 2019
Manuscripts (preprints)
Other
Non-peptide AT2-receptor agonists
Part of Medicinal Chemistry Reviews, 2016