Staffan Svärd

Host range expansion of asexual parasite can be explained by loss of adaptions in Muller's Ratchet

Tichkule, Swapnil; Van Oosterhout, Cock; Caccio, Simone M.; Weisz, Filip et al.

Part of Nature Communications, 2025

• DOI for Host range expansion of asexual parasite can be explained by loss of adaptions in Muller's Ratchet
• Download full text (pdf) of Host range expansion of asexual parasite can be explained by loss of adaptions in Muller's Ratchet

The expanded genome of Hexamita inflata, a free-living diplomonad

Akdeniz, Zeynep; Havelka, Michal; Stoklasa, Michal; Jiménez-González, Alejandro et al.

Part of Scientific Data, 2025

• DOI for The expanded genome of Hexamita inflata, a free-living diplomonad
• Download full text (pdf) of The expanded genome of Hexamita inflata, a free-living diplomonad

Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis

Ranjbarian, Farahnaz; Rafie, Karim; Shankar, Kasturika; Krakovka, Sascha et al.

Part of Nucleic Acids Research, p. 14061-14076, 2024

• DOI for Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis
• Download full text (pdf) of Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis

Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure

Dube, Faruk; Delhomme, Nicolas; Martin, Frida; Hinas, Andrea et al.

Part of PLOS ONE, 2024

• DOI for Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure
• Download full text (pdf) of Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure

Occurrence of intestinal parasites and bacteria, with the emphasis on Giardia intestinalis in children under 5 years old in Magude village, Maputo, Mozambique

Lindh, Johan; Casmo, Veronica; Noormahomed, Emilia; Knörr, Livia et al.

Part of Transactions of the Royal Society of Tropical Medicine and Hygiene, 2024

Host range expansion of asexual parasite can be explained by loss of adaptions in Muller's Ratchet

Tichkule, Swapnil; Van Oosterhout, Cock; Caccio, Simone M.; Weisz, Filip et al.

Part of Nature Communications, 2025

• DOI for Host range expansion of asexual parasite can be explained by loss of adaptions in Muller's Ratchet
• Download full text (pdf) of Host range expansion of asexual parasite can be explained by loss of adaptions in Muller's Ratchet

The expanded genome of Hexamita inflata, a free-living diplomonad

Akdeniz, Zeynep; Havelka, Michal; Stoklasa, Michal; Jiménez-González, Alejandro et al.

Part of Scientific Data, 2025

• DOI for The expanded genome of Hexamita inflata, a free-living diplomonad
• Download full text (pdf) of The expanded genome of Hexamita inflata, a free-living diplomonad

Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis

Ranjbarian, Farahnaz; Rafie, Karim; Shankar, Kasturika; Krakovka, Sascha et al.

Part of Nucleic Acids Research, p. 14061-14076, 2024

• DOI for Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis
• Download full text (pdf) of Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis

Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure

Dube, Faruk; Delhomme, Nicolas; Martin, Frida; Hinas, Andrea et al.

Part of PLOS ONE, 2024

• DOI for Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure
• Download full text (pdf) of Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure

Occurrence of intestinal parasites and bacteria, with the emphasis on Giardia intestinalis in children under 5 years old in Magude village, Maputo, Mozambique

Lindh, Johan; Casmo, Veronica; Noormahomed, Emilia; Knörr, Livia et al.

Part of Transactions of the Royal Society of Tropical Medicine and Hygiene, 2024

Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis

Majumdar, Soneya; Emmerich, Andrew G; Krakovka, Sascha; Mandava, Chandra Sekhar et al.

Part of Nucleic Acids Research, p. 3436-3451, 2023

• DOI for Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis
• Download full text (pdf) of Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis

Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain

Dube, Faruk; Hinas, Andrea; Delhomme, Nicolas; Åbrink, Magnus et al.

Part of PLOS ONE, 2023

• DOI for Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain
• Download full text (pdf) of Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain

Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis

Motyckova, Alzbeta; Voleman, Lubos; Najdrova, Vladimira; Arbonova, Lenka et al.

Part of PLoS Pathogens, 2023

• DOI for Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis
• Download full text (pdf) of Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis

Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis

Su, Qiao; Baker, Louise; Emery, Samantha; Balan, Balu et al.

Part of International Journal for Parasitology, p. 9-19, 2023

• DOI for Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis
• Download full text (pdf) of Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis

Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection

Grüttner, Jana; van Rijn, Jorik M.; Geiser, Petra; Florbrant, Alexandra et al.

Part of PLoS Pathogens, 2023

• DOI for Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection
• Download full text (pdf) of Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection

Ivermectin-induced gene expression changes in adult Parascaris univalens and Caenorhabditis elegans: a comparative approach to study anthelminthic metabolism and resistance in vitro

Dube, Faruk; Hinas, Andrea; Roy, Shweta; Martin, Frida et al.

Part of Parasites & Vectors, 2022

• DOI for Ivermectin-induced gene expression changes in adult Parascaris univalens and Caenorhabditis elegans: a comparative approach to study anthelminthic metabolism and resistance in vitro
• Download full text (pdf) of Ivermectin-induced gene expression changes in adult Parascaris univalens and Caenorhabditis elegans: a comparative approach to study anthelminthic metabolism and resistance in vitro

A chromosome-scale reference genome for Spironucleus salmonicida

Xu, Feifei; Jimenez-Gonzalez, Alejandro; Kurt, Zeynep; Ástvaldsson, Ásgeir et al.

Part of Scientific Data, 2022

• DOI for A chromosome-scale reference genome for Spironucleus salmonicida
• Download full text (pdf) of A chromosome-scale reference genome for Spironucleus salmonicida

Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery

Krakovka, Sascha; Ranjbarian, Farahnaz; Lujan, Lucas A.; Saura, Alicia et al.

Part of Journal of Biological Chemistry, 2022

• DOI for Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery
• Download full text (pdf) of Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery

Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada

Santos, Rui; Astvaldsson, Asgeir; Pipaliya, Shweta; Zumthor, Jon Paulin et al.

Part of BMC Biology, 2022

• DOI for Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada
• Download full text (pdf) of Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada

Characterization of Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and Proteomics

Krakovka, Sascha; Ribacke, Ulf; Miyamoto, Yukiko; Eckmann, Lars et al.

Part of Frontiers in Microbiology, 2022

• DOI for Characterization of Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and Proteomics
• Download full text (pdf) of Characterization of Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and Proteomics

High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium

van Rijn, Jorik M.; Eriksson, Jens; Grüttner, Jana; Sundbom, Magnus et al.

Part of mBio, 2022

• DOI for High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium
• Download full text (pdf) of High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium

Comprehensive characterization of Cysteine-rich protein-coding genes of Giardia lamblia and their role during antigenic variation

Rodriguez-Walker, Macarena; Molina, Cecilia R.; Lujan, Lucas A.; Saura, Alicia et al.

Part of Genomics, 2022

• DOI for Comprehensive characterization of Cysteine-rich protein-coding genes of Giardia lamblia and their role during antigenic variation
• Download full text (pdf) of Comprehensive characterization of Cysteine-rich protein-coding genes of Giardia lamblia and their role during antigenic variation

Giardia duodenalis

Rojas-Lopez, Laura; Marques, Rafael C.; Svärd, Staffan

Part of Trends in Parasitology, p. 605-606, 2022

• DOI for Giardia duodenalis
• Download full text (pdf) of Giardia duodenalis

A Detailed Gene Expression Map of Giardia Encystation

Rojas-Lopez, Laura; Krakovka, Sascha; Einarsson, Elin; Ribacke, Ulf et al.

Part of Genes, p. 1932, 2021

• DOI for A Detailed Gene Expression Map of Giardia Encystation
• Download full text (pdf) of A Detailed Gene Expression Map of Giardia Encystation

Dual RNA-seq transcriptome analysis of caecal tissue during primary Eimeria tenella infection in chickens

Sandholt, Arnar K. S.; Wattrang, Eva; Lilja, Tobias; Ahola, Harri et al.

Part of BMC Genomics, 2021

• DOI for Dual RNA-seq transcriptome analysis of caecal tissue during primary Eimeria tenella infection in chickens
• Download full text (pdf) of Dual RNA-seq transcriptome analysis of caecal tissue during primary Eimeria tenella infection in chickens

Serglycin-Deficiency Causes Reduced Weight Gain and Changed Intestinal Cytokine Responses in Mice Infected With Giardia intestinalis

Li, Zhiqiang; Peirasmaki, Dimitra; Svärd, Staffan; Åbrink, Magnus

Part of Frontiers in Immunology, 2021

• DOI for Serglycin-Deficiency Causes Reduced Weight Gain and Changed Intestinal Cytokine Responses in Mice Infected With Giardia intestinalis
• Download full text (pdf) of Serglycin-Deficiency Causes Reduced Weight Gain and Changed Intestinal Cytokine Responses in Mice Infected With Giardia intestinalis

Eukaryote-conserved histone post-translational modification landscape in Giardia duodenalis revealed by mass spectrometry

Emery-Corbin, Samantha J.; Hamey, Joshua J.; Balan, Balu; Rojas-López, Laura et al.

Part of International Journal of Parasitology, p. 225-239, 2021

• DOI for Eukaryote-conserved histone post-translational modification landscape in Giardia duodenalis revealed by mass spectrometry

Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics

Balan, Balu; Emery-Corbin, Samantha J.; Sandow, Jarrod J.; Ansell, Brendan Robert E. et al.

Part of International Journal of Parasitology, p. 809-824, 2021

• DOI for Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics
• Download full text (pdf) of Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics

Dual RNA-Seq transcriptome analysis of chicken macrophage-like cells (HD11) infected in vitro with Eimeria tenella

Sandholt, Arnar K. S.; Xu, Feifei; Söderlund, Robert; Lundén, Anna et al.

Part of Parasitology, p. 712-725, 2021

• DOI for Dual RNA-Seq transcriptome analysis of chicken macrophage-like cells (HD11) infected in vitro with Eimeria tenella
• Download full text (pdf) of Dual RNA-Seq transcriptome analysis of chicken macrophage-like cells (HD11) infected in vitro with Eimeria tenella

Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in Giardia

Emery-Corbin, Samantha J.; Hamey, Joshua J.; Ansell, Brendan R. E.; Balan, Balu et al.

Part of Molecular biology and evolution, p. 3525-3549, 2020

• DOI for Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in Giardia
• Download full text (pdf) of Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in Giardia

High Cysteine Membrane Proteins (HCMPs) Are Up-Regulated DuringGiardia-Host Cell Interactions

Peirasmaki, Dimitra; Ma'ayeh, Showgy Y.; Xu, Feifei; Ferella, Marcela et al.

Part of Frontiers in Genetics, 2020

• DOI for High Cysteine Membrane Proteins (HCMPs) Are Up-Regulated DuringGiardia-Host Cell Interactions
• Download full text (pdf) of High Cysteine Membrane Proteins (HCMPs) Are Up-Regulated DuringGiardia-Host Cell Interactions

The Chymase Mouse Mast Cell Protease-4 Regulates Intestinal Cytokine Expression in Mature Adult Mice Infected with Giardia intestinalis

Li, Zhiqiang; Peirasmaki, Dimitra; Svärd, Staffan; Åbrink, Magnus

Part of Cells, 2020

• DOI for The Chymase Mouse Mast Cell Protease-4 Regulates Intestinal Cytokine Expression in Mature Adult Mice Infected with Giardia intestinalis
• Download full text (pdf) of The Chymase Mouse Mast Cell Protease-4 Regulates Intestinal Cytokine Expression in Mature Adult Mice Infected with Giardia intestinalis

The compact genome of Giardia muris reveals important steps in the evolution of intestinal protozoan parasites

Xu, Feifei; Jimenez-Gonzalez, Alejandro; Einarsson, Elin; Ástvaldsson, Ásgeir et al.

Part of Microbial Genomics, 2020

• DOI for The compact genome of Giardia muris reveals important steps in the evolution of intestinal protozoan parasites

A chromosome-scale reference genome for Giardia intestinalis WB

Xu, Feifei; Jex, Aaron; Svärd, Staffan

Part of Scientific Data, 2020

• DOI for A chromosome-scale reference genome for Giardia intestinalis WB
• Download full text (pdf) of A chromosome-scale reference genome for Giardia intestinalis WB

Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida

Stairs, Courtney W.; Kokla, Anna; Astvaldsson, Asgeir; Jerlström-Hultqvist, Jon et al.

Part of BMC Biology, 2019

• DOI for Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida
• Download full text (pdf) of Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida

Giardia intestinalis cystatin is a potent inhibitor of papain, parasite cysteine proteases and, to a lesser extent, human cathepsin B

Liu, Jingyi; Svärd, Staffan; Klotz, Christian

Part of FEBS Letters, p. 1313-1325, 2019

• DOI for Giardia intestinalis cystatin is a potent inhibitor of papain, parasite cysteine proteases and, to a lesser extent, human cathepsin B

Further evaluation of recombinant Tsol-p27 by enzyme-linked immunoelectrotransfer blot for the serodiagnosis of cysticercosis in pigs from Mozambique

Nhancupe, Noemia; Noormahomed, Emilia V.; Afonso, Sonia; Svärd, Staffan et al.

Part of Parasites & Vectors, 2019

• DOI for Further evaluation of recombinant Tsol-p27 by enzyme-linked immunoelectrotransfer blot for the serodiagnosis of cysticercosis in pigs from Mozambique
• Download full text (pdf) of Further evaluation of recombinant Tsol-p27 by enzyme-linked immunoelectrotransfer blot for the serodiagnosis of cysticercosis in pigs from Mozambique

Identification of Conserved Candidate Vaccine Antigens in the Surface Proteome of Giardia lamblia

Davids, Barbara J.; Liu, Ching M.; Hanson, Elaine M.; Le, Christine H. Y. et al.

Part of Infection and Immunity, 2019

• DOI for Identification of Conserved Candidate Vaccine Antigens in the Surface Proteome of Giardia lamblia

Proximity Staining using Enzymatic Protein Tagging in Diplomonads

Astvaldsson, Asgeir; Hultenby, Kjell; Svärd, Staffan; Jerlstrom-Hultqvist, Joel

Part of mSphere, 2019

• DOI for Proximity Staining using Enzymatic Protein Tagging in Diplomonads
• Download full text (pdf) of Proximity Staining using Enzymatic Protein Tagging in Diplomonads

Giardia excretory-secretory proteins modulate the enzymatic activities of mast cell chymase and tryptase

Li, Zhiqiang; Peirasmaki, Dimitra; Svärd, Staffan; Åbrink, Magnus

Part of Molecular Immunology, p. 535-544, 2019

• DOI for Giardia excretory-secretory proteins modulate the enzymatic activities of mast cell chymase and tryptase

Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins

Liu, Jingyi; Fu, Zhirong; Hellman, Lars; Svärd, Staffan G.

Part of Molecular and biochemical parasitology (Print), p. 29-38, 2019

• DOI for Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins

Proteomic diversity in a prevalent human-infective Giardia duodenalis sub-species

Emery-Corbin, Samantha J.; Vuong, Daniel; Lacey, Ernest; Svärd, Staffan et al.

Part of International Journal of Parasitology, p. 817-823, 2018

• DOI for Proteomic diversity in a prevalent human-infective Giardia duodenalis sub-species

A novel high-resolution multilocus sequence typing of Giardia intestinalis Assemblage A isolates reveals zoonotic transmission, clonal outbreaks and recombination

Ankarklev, Johan; Lebbad, Marianne; Einarsson, Elin; Franzen, Oscar et al.

Part of Infection, Genetics and Evolution, p. 7-16, 2018

• DOI for A novel high-resolution multilocus sequence typing of Giardia intestinalis Assemblage A isolates reveals zoonotic transmission, clonal outbreaks and recombination

Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis

Emery, Samantha J.; Baker, Louise; Ansell, Brendan R. E.; Mirzaei, Mehdi et al.

Part of GigaScience, 2018

• DOI for Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis
• Download full text (pdf) of Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis

Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines

Liu, Jingyi; Ma'ayeh, Showgy Y.; Peirasmaki, Dimitra; Lundstrom-Stadelmann, Britta et al.

Part of Virulence, p. 879-894, 2018

• DOI for Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines
• Download full text (pdf) of Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines

Responses of the Differentiated Intestinal Epithelial Cell Line Caco-2 to Infection With the Giardia intestinalis GS Isolate

Ma'ayeh, Showgy Y.; Knörr, Livia; Sköld, Karin; Garnham, Alexandra et al.

Part of Frontiers in Cellular and Infection Microbiology, 2018

• DOI for Responses of the Differentiated Intestinal Epithelial Cell Line Caco-2 to Infection With the Giardia intestinalis GS Isolate
• Download full text (pdf) of Responses of the Differentiated Intestinal Epithelial Cell Line Caco-2 to Infection With the Giardia intestinalis GS Isolate

Recent advances in the genomic and molecular biology of Giardia

Guadalupe Ortega-Pierres, M.; Jex, Aaron R.; Ansell, Brendan R. E.; Svärd, Staffan

Part of Acta Tropica, p. 67-72, 2018

• DOI for Recent advances in the genomic and molecular biology of Giardia

Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines

Ansell, Brendan R. E.; Baker, Louise; Emery, Samantha J.; McConville, Malcolm J. et al.

Part of Frontiers in Microbiology, 2017

• DOI for Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines
• Download full text (pdf) of Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines

Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum

Voleman, Lubos; Najdrova, Vladimira; Ástvaldsson, Ásgeir; Tumova, Pavla et al.

Part of BMC Biology, 2017

• DOI for Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum
• Download full text (pdf) of Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum

Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome

Hanevik, Kurt; Kristoffersen, Einar; Morch, Kristine; Rye, Kristin Paulsen et al.

Part of BMC Immunology, 2017

• DOI for Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome
• Download full text (pdf) of Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome

Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells

Ma'ayeh, Showgy Y.; Liu, Jingyi; Peirasmaki, Dimitra; Hörnaeus, Katarina et al.

Part of PLoS Neglected Tropical Diseases, 2017

• DOI for Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells
• Download full text (pdf) of Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells

Endoplasmic reticulum is the sorting core facility in the Golgi-lacking protozoan Giardia lamblia

Zamponi, Nahuel; Zamponi, Emiliano; Mayol, Gonzalo F.; Lanfredi-Rangel, Adriana et al.

Part of Traffic, p. 604-621, 2017

• DOI for Endoplasmic reticulum is the sorting core facility in the Golgi-lacking protozoan Giardia lamblia

On the reversibility of parasitism: adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp PC1

Xu, Feifei; Jerlström-Hultqvist, Jon; Kolisko, Martin; Simpson, Alastair G. B. et al.

Part of BMC Biology, 2016

• DOI for On the reversibility of parasitism: adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp PC1
• Download full text (pdf) of On the reversibility of parasitism: adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp PC1

Comparative cell biology and evolution of Annexins in Diplomonads

Einarsson, Elin; Ástvaldsson, Ásgeir; Hultenby, Kjell; Andersson, Jan O. et al.

Part of mSphere, 2016

• DOI for Comparative cell biology and evolution of Annexins in Diplomonads

Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis

Ansell, Brendan R. E.; McConville, Malcolm J.; Baker, Louise; Korhonen, Pasi K. et al.

Part of Antimicrobial Agents and Chemotherapy, p. 6034-6045, 2016

• DOI for Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis

Coordinated Changes in Gene Expression Throughout Encystation of Giardia intestinalis

Einarsson, Elin; Troell, Karin; Höppner, Marc; Grabherr, Mannfred et al.

Part of PLoS Neglected Tropical Diseases, 2016

• DOI for Coordinated Changes in Gene Expression Throughout Encystation of Giardia intestinalis
• Download full text (pdf) of Coordinated Changes in Gene Expression Throughout Encystation of Giardia intestinalis

Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia

Carranza, Pedro G.; Gargantini, Pablo R.; Prucca, Cesar G.; Torri, Alessandro et al.

Part of International Journal of Biochemistry and Cell Biology, p. 32-43, 2016

• DOI for Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia

Human Memory CD4+ T Cell Immune Responses against Giardia lamblia

Saghaug, Christina Skar; Sornes, Steinar; Peirasmaki, Dimitra; Svärd, Staffan et al.

Part of Clinical and Vaccine Immunology, p. 11-18, 2016

• DOI for Human Memory CD4+ T Cell Immune Responses against Giardia lamblia

Comparative genomic analyses of freshly isolated Giardia intestinalis assemblage A isolates

Ankarklev, Johan; Franzen, Oscar; Peirasmaki, Dimitra; Jerlstrom-Hultqvist, Jon et al.

Part of BMC Genomics, 2015

• DOI for Comparative genomic analyses of freshly isolated Giardia intestinalis assemblage A isolates
• Download full text (pdf) of Comparative genomic analyses of freshly isolated Giardia intestinalis assemblage A isolates

UV irradiation responses in Giardia intestinalis

Einarsson, Elin; Svärd, Staffan G.; Troell, Karin

Part of Experimental parasitology, p. 25-32, 2015

• DOI for UV irradiation responses in Giardia intestinalis

A real-time assemblage-specific PCR assay for the detection of Giardia duodenalis assemblages A, B and E in fecal samples

Van Lith, Lindy; Soba, Barbara; Vizcaino, Vivian Villalba; Svärd, Staffan et al.

Part of Veterinary parasitology, p. 28-34, 2015

• DOI for A real-time assemblage-specific PCR assay for the detection of Giardia duodenalis assemblages A, B and E in fecal samples

Transcriptional profiling of Giardia intestinalis in response to oxidative stress

Ma'ayeh, Showgy Y.; Knörr, Livia; Svärd, Staffan G.

Part of International Journal of Parasitology, p. 925-938, 2015

• DOI for Transcriptional profiling of Giardia intestinalis in response to oxidative stress

Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites

Ansell, Brendan R. E.; McConville, Malcolm J.; Baker, Louise; Korhonen, Pasi K. et al.

Part of PLoS Neglected Tropical Diseases, 2015

• DOI for Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites
• Download full text (pdf) of Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites

The genome of Spironucleus salmonicida highlights a fish pathogen adapted to fluctuating environments

Xu, Feifei; Jerlström-Hultqvist, Jon; Einarsson, Elin; Astvaldsson, Asgeir et al.

Part of PLOS Genetics, 2014

• DOI for The genome of Spironucleus salmonicida highlights a fish pathogen adapted to fluctuating environments
• Download full text (pdf) of The genome of Spironucleus salmonicida highlights a fish pathogen adapted to fluctuating environments

Rolf Bernander (1956-2014): pioneer of the archaeal cell cycle Obituary

Ettema, Thijs J. G.; Lindås, Ann-Christin; Hjort, Karin; Poplawski, Andrzej B. et al.

Part of Molecular Microbiology, p. 903-909, 2014

• DOI for Rolf Bernander (1956-2014): pioneer of the archaeal cell cycle Obituary

Gene expression changes during Giardia-host cell interactions in serum-free medium

Ferella, Marcela; Davids, Barbara J; Cipriano, Michael J; Birkeland, Shanda R et al.

Part of Molecular and biochemical parasitology (Print), p. 21-23, 2014

• DOI for Gene expression changes during Giardia-host cell interactions in serum-free medium

The role of arginine and arginine-metabolizing enzymes during Giardia - host cell interactions in vitro

Stadelmann, Britta; Hanevik, Kurt; Andersson, Mattias K.; Bruserud, Oystein et al.

Part of BMC Microbiology, p. 256, 2013

• DOI for The role of arginine and arginine-metabolizing enzymes during Giardia - host cell interactions in vitro

Transcriptome Profiling of Giardia intestinalis Using Strand-specific RNAseq

Franzén, Oscar; Jerlström-Hultqvist, Jon; Einarsson, Elin; Ankarklev, Johan et al.

Part of PloS Computational Biology, 2013

• DOI for Transcriptome Profiling of Giardia intestinalis Using Strand-specific RNAseq
• Download full text (pdf) of Transcriptome Profiling of Giardia intestinalis Using Strand-specific RNAseq

Hydrogenosomes in the diplomonad Spironucleus salmonicida

Jerlström-Hultqvist, Jon; Einarsson, Elin; Xu, Feifei; Hjort, Karin et al.

Part of Nature Communications, p. 2493, 2013

• DOI for Hydrogenosomes in the diplomonad Spironucleus salmonicida

Common Coinfections of Giardia intestinalis and Helicobacter pylori in Non-Symptomatic Ugandan Children

Ankarklev, Johan; Hestvik, Elin; Lebbad, Marianne; Lindh, Johan et al.

Part of PLOS Neglected Tropical Diseases, 2012

• DOI for Common Coinfections of Giardia intestinalis and Helicobacter pylori in Non-Symptomatic Ugandan Children
• Download full text (pdf) of Common Coinfections of Giardia intestinalis and Helicobacter pylori in Non-Symptomatic Ugandan Children

Allelic sequence heterozygosity in single Giardia parasites

Ankarklev, Johan; Svärd, Staffan; Lebbad, Marianne

Part of BMC Microbiology, 2012

• DOI for Allelic sequence heterozygosity in single Giardia parasites

Plasmid Vectors for Proteomic Analyses in Giardia: Purification of Virulence Factors and Analysis of the Proteasome

Jerlström-Hultqvist, Jon; Stadelmann, Britta; Birkestedt, Sandra; Hellman, Ulf et al.

Part of Eukaryotic Cell, p. 864-873, 2012

• DOI for Plasmid Vectors for Proteomic Analyses in Giardia: Purification of Virulence Factors and Analysis of the Proteasome

Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells

Stadelmann, Britta; Merino, Maria C.; Persson, Lo; Svärd, Staffan G.

Part of PLOS ONE, 2012

• DOI for Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells
• Download full text (pdf) of Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells

Stable transfection of the diplomonad parasite Spironucleus salmonicida

Jerlström-Hultqvist, Jon; Einarsson, Elin; Svärd, Staffan G

Part of Eukaryotic Cell, p. 1353-1361, 2012

• DOI for Stable transfection of the diplomonad parasite Spironucleus salmonicida

Laboratory cryo soft X-ray microscopy

Hertz, H. M.; von Hofsten, O.; Bertilson, M.; Vogt, U. et al.

Part of Journal of Structural Biology, p. 267-272, 2012

• DOI for Laboratory cryo soft X-ray microscopy

Alpha-1 Giardin is an Annexin with Highly Unusual Calcium-Regulated Mechanisms

Weeratunga, Saroja K.; Osman, Asiah; Hu, Nien-Jen; Wang, Conan K. et al.

Part of Journal of Molecular Biology, p. 169-181, 2012

• DOI for Alpha-1 Giardin is an Annexin with Highly Unusual Calcium-Regulated Mechanisms

Detection of Giardia duodenalis Assemblages A and B in Human Feces by Simple, Assemblage-Specific PCR Assays

Vanni, Ilaria; Caccio, Simone Mario; van Lith, Lindy; Lebbad, Marianne et al.

Part of PLOS Neglected Tropical Diseases, 2012

• DOI for Detection of Giardia duodenalis Assemblages A and B in Human Feces by Simple, Assemblage-Specific PCR Assays
• Download full text (pdf) of Detection of Giardia duodenalis Assemblages A and B in Human Feces by Simple, Assemblage-Specific PCR Assays

Transcriptional changes in Giardia during host-parasite interactions

Ringqvist, Emma; Avesson, Lotta; Söderbom, Fredrik; Svärd, Staffan

Part of International Journal for Parasitology, p. 277-285, 2011

• DOI for Transcriptional changes in Giardia during host-parasite interactions

Real-time polymerase chain reaction followed by fast sequencing allows rapid genotyping of microbial pathogens

Wahab, Tara; Ankarklev, Johan; Lebbad, Marianne; Glavas, Steve et al.

Part of Scandinavian Journal of Infectious Diseases, p. 95-99, 2011

• DOI for Real-time polymerase chain reaction followed by fast sequencing allows rapid genotyping of microbial pathogens

Multilocus Genotyping of Human Giardia Isolates Suggests Limited Zoonotic Transmission and Association between Assemblage B and Flatulence in Children

Lebbad, Marianne; Petersson, Ingvor; Karlsson, Lillemor; Botero-Kleiven, Silvia et al.

Part of PLoS Neglected Tropical Diseases, 2011

• DOI for Multilocus Genotyping of Human Giardia Isolates Suggests Limited Zoonotic Transmission and Association between Assemblage B and Flatulence in Children

Elongation factor 1-alpha is released into the culture medium during growth of Giardia intestinalis trophozoites

Skarin, Hanna; Ringqvist, Emma; Hellman, Ulf; Svärd, Staffan G.

Part of Experimental parasitology, p. 804-810, 2011

• DOI for Elongation factor 1-alpha is released into the culture medium during growth of Giardia intestinalis trophozoites

alpha 1-giardin based live heterologous vaccine protects against Giardia lamblia infection in a murine model

Jenikova, Gabriela; Hruz, Petr; Andersson, Mattias K.; Tejman-Yarden, Noa et al.

Part of Vaccine, p. 9529-9537, 2011

• DOI for alpha 1-giardin based live heterologous vaccine protects against Giardia lamblia infection in a murine model

Human Cellular Immune Response Against Giardia lamblia 5 Years After Acute Giardiasis

Hanevik, Kurt; Kristoffersen, Einar; Svärd, Staffan; Bruserud, Oystein et al.

Part of Journal of Infectious Diseases, p. 1779-1786, 2011

• DOI for Human Cellular Immune Response Against Giardia lamblia 5 Years After Acute Giardiasis

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

Manning, Gerard; Reiner, David S.; Lauwaet, Tineke; Dacre, Michael et al.

Part of Genome Biology, 2011

• DOI for The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology
• Download full text (pdf) of The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

Large genomic differences between the morphologically indistinguishable diplomonads Spironucleus barkhanus and Spironucleus salmonicida

Roxström-Lindquist, Katarina; Jerlström-Hultqvist, Jon; Jörgensen, Anders; Troell, Karin et al.

Part of BMC Genomics, 2010

• DOI for Large genomic differences between the morphologically indistinguishable diplomonads Spironucleus barkhanus and Spironucleus salmonicida
• Download full text (pdf) of Large genomic differences between the morphologically indistinguishable diplomonads Spironucleus barkhanus and Spironucleus salmonicida

Comment on article by Eligio-Garcia et al. entitled "Frequency of Giardia intestinalis assemblages isolated from dogs and humans in a community from Culiacan, Sinaloa, Mexico using beta-giardin restriction gene"

Lebbad, Marianne; Svärd, Staffan

Part of Veterinary parasitology, p. 159-160, 2008

• DOI for Comment on article by Eligio-Garcia et al. entitled "Frequency of Giardia intestinalis assemblages isolated from dogs and humans in a community from Culiacan, Sinaloa, Mexico using beta-giardin restriction gene"

Dominance of Giardia assemblage B in León, Nicaragua.

Lebbad, Marianne; Ankarklev, Johan; Tellez, Aleyda; Leiva, Byron et al.

Part of Acta Tropica, p. 44-53, 2008

• DOI for Dominance of Giardia assemblage B in León, Nicaragua.

Eukaryotic RNase P RNA mediates cleavage in the absence of protein

Kikovska, Ema; Svärd, Staffan; Kirsebom, Leif

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 2062-2067, 2007

• DOI for Eukaryotic RNase P RNA mediates cleavage in the absence of protein

Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation

Lauwaet, Tineke; Davids, Barbara J.; Torres-Escobar, Ascención; Birkeland, Shanda R. et al.

Part of Molecular and biochemical parasitology (Print), p. 80-89, 2007

• DOI for Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation

Secretory antibodies against Giardia intestinalis in lactating Nicaraguan women.

Tellez, A; Palm, D; Weiland, M; Alemán, J et al.

Part of Parasite Immunol, p. 163-9, 2005

Developmental changes in the adhesive disk during Giardia differentiation.

Palm, Daniel; Weiland, Malin; McArthur, Andrew G; Winiecka-Krusnell, Jadwiga et al.

Part of Mol Biochem Parasitol, p. 199-207, 2005

Giardia lamblia-induced changes in gene expression in differentiated Caco-2

Roxström-Lindquist, Katarina; Ringqvist, Emma; Palm, Daniel; Svärd, Staffan

Part of Infect Immun, p. 8204-8, 2005

Update on Giardia: Highlights from the seventh International Giardia and Cryptosporidium Conference

Buret, Andre G.; Caccio, Simone M.; Favennec, Loic; Svärd, Staffan

Part of Parasite, 2020

• DOI for Update on Giardia: Highlights from the seventh International Giardia and Cryptosporidium Conference
• Download full text (pdf) of Update on Giardia: Highlights from the seventh International Giardia and Cryptosporidium Conference

Host specificity in the Giardia duodenalis species complex

Caccio, Simone M.; Lalle, Marco; Svärd, Staffan

Part of Infection, Genetics and Evolution, p. 335-345, 2018

• DOI for Host specificity in the Giardia duodenalis species complex

An up-date on Giardia and giardiasis

Einarsson, Elin; Ma'ayeh, Showgy Y.; Svärd, Staffan G.

Part of Current Opinion in Microbiology, p. 47-52, 2016

• DOI for An up-date on Giardia and giardiasis

Drug resistance in Giardia duodenalis

Ansell, Brendan R. E.; McConville, Malcolm J.; Ma'ayeh, Showgy Y.; Dagley, Michael J. et al.

Part of Biotechnology Advances, p. 888-901, 2015

• DOI for Drug resistance in Giardia duodenalis

Behind the smile: cell biology and disease mechanisms of Giardia species

Ankarklev, Johan; Jerlström-Hultqvist, Jon; Ringqvist, Emma; Troell, Karin et al.

Part of Nature Reviews Microbiology, p. 413-422, 2010

• DOI for Behind the smile: cell biology and disease mechanisms of Giardia species

A genomic survey of the fish parasite Spironucleus salmonicida indicates genomic plasticity among diplomonads and significant lateral gene transfer in eukaryote genome evolution

Andersson, Jan O.; Sjögren, Åsa M.; Horner, David S.; Murphy, Colleen A. et al.

Part of BMC Genomics, p. 51, 2007

• DOI for A genomic survey of the fish parasite Spironucleus salmonicida indicates genomic plasticity among diplomonads and significant lateral gene transfer in eukaryote genome evolution

Transcriptomic and proteomic analyses of Giardia intestinalis: Intestinal epithelial cell interactions

Emery-Corbin, Samantha J.; Grüttner, Jana; Svärd, Staffan

Part of Giardia And Giardiasis, Pt B, p. 139-171, Elsevier, 2020

• DOI for Transcriptomic and proteomic analyses of Giardia intestinalis: Intestinal epithelial cell interactions

Recent advances in functional research in Giardia intestinalis

Jex, Aaron R.; Svärd, Staffan; Hagen, Kari D.; Starcevich, Hannah et al.

Part of Giardia And Giardiasis, Pt B, p. 97-137, Elsevier, 2020

• DOI for Recent advances in functional research in Giardia intestinalis

The genome of Giardia and other diplomonads

Andersson, Jan O.; Jerlström-Hultqvist, Jon; Svärd, Staffan G.

Part of Anaerobic Parasitic Protozoa: Genomics and Molecular Biology, p. 23-44, Caister Academic Press, 2010

Experimental challenge of Atlantic salmon (Salmo salar) with the diplomonad parasite Spironucleus salmonicida to characterize the infection cycle

Anders, Alfjorden; Astvaldsson, Asgeir; Eva, Jansson; Svärd, Staffan

High Cysteine Proteins are up-regulated during Giardia-host cell interaction.

Peirasmaki, Dimitra; Ma'ayeh, Showgy Y.; Xu, Feifei; Ferella, Marcela et al.

Proteome analyses of Giardia–host cell interactions in vitro.

Peirasmaki, Dimitra; Xia, Dong; Attree, Elizabeth; Ferella, Marcela et al.

Proteomic profiling of host cell responses during Giardia intestinalis interaction with intestinal epithelial Caco-2 cells

Grüttner, Jana; Svärd, Staffan

Dual transcriptomic analysis of Spironucleus salmonicida-infected salmon cells identifies putative virulence factors and host responses

Astvaldsson, Asgeir; Stairs, Courtney W.; Xu, Feifei; Haag, Lars et al.