Klas Kullander
- Mobile phone:
- +46 70 846 75 24
- E-mail:
- klas.kullander@igp.uu.se
- Visiting address:
- BMC
Husargatan 3
751 23 UPPSALA - Postal address:
- IGP / BMC
Box 815
751 08 Uppsala
- Academic merits:
- PhD, Associate Professor
- CV:
- Download CV
Short presentation
Klas Kullander is devoted to understand neuronal circuitries in the brain and spinal cord. He started the unit of developmental genetics in 2004 with the aim of building a creative and interactive environment with state of the art methodologies for doing the best possible analysis of nervous system function.
Biography
PhD in Medicine: Uppsala University 1997-05-22, Thesis title: Evolutionary and structure-function studies of neurotrophins, supervisor Prof. Ted Ebendal
Postdoctoral traning: EMBL, Heidelberg 1998-01-15 to 2001-12-30, In the laboratory of Prof. Rüdiger Klein
Associate Professor: Neuroscience, Uppsala University, 2005
Professor: Developmental Genetics, Uppsala University, 2010
Research
Functional neuronal networks
Neuronal networks control various behaviors ranging from reflexive movements to advanced cognitive functions. The smallest functional unit, the nerve cell, connects to other nerve cells during development to form neuronal networks. Our research focuses on neuronal network function, to find genetic identities for nerve cells and to define their role in neuronal circuits.
Two limiting factors in the disentanglement of neural circuit function are the identification of defined populations of interneurons and the use of reproducible behaviors. Thus, sharp genetic tools in combination with in vitro and in vivo measurements of network activity and behavior are instrumental. We apply novel and advanced methods, including virus-based tracing, electrophysiology, optogenetics, and in-vivo imaging of neural activity. We strive towards state-of-the-art interrogation of neuronal circuits, supported by facilities for behavior and viral delivery of optogenetic and monosynaptic tracing tools.

Publications
Recent publications
Part of Hippocampus, 2025
- DOI for Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function
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Part of European Journal of Neuroscience, 2025
- DOI for Layer-Specific Connectivity and Functional Interference of Chrna2+Layer 5 Martinotti Cells in the Primary Motor Cortex
- Download full text (pdf) of Layer-Specific Connectivity and Functional Interference of Chrna2+Layer 5 Martinotti Cells in the Primary Motor Cortex
Functional specialization of hippocampal somatostatin-expressing interneurons
Part of Proceedings of the National Academy of Sciences of the United States of America, 2024
- DOI for Functional specialization of hippocampal somatostatin-expressing interneurons
- Download full text (pdf) of Functional specialization of hippocampal somatostatin-expressing interneurons
Part of PLoS biology, 2024
- DOI for Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis
- Download full text (pdf) of Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis
Part of BMC Neuroscience, 2024
- DOI for A flowchart for adequate controls in virus-based monosynaptic tracing experiments identified Cre-independent leakage of the TVA receptor in RΊGT mice
- Download full text (pdf) of A flowchart for adequate controls in virus-based monosynaptic tracing experiments identified Cre-independent leakage of the TVA receptor in RΊGT mice
All publications
Articles in journal
Part of Hippocampus, 2025
- DOI for Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function
- Download full text (pdf) of Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function
Part of European Journal of Neuroscience, 2025
- DOI for Layer-Specific Connectivity and Functional Interference of Chrna2+Layer 5 Martinotti Cells in the Primary Motor Cortex
- Download full text (pdf) of Layer-Specific Connectivity and Functional Interference of Chrna2+Layer 5 Martinotti Cells in the Primary Motor Cortex
Functional specialization of hippocampal somatostatin-expressing interneurons
Part of Proceedings of the National Academy of Sciences of the United States of America, 2024
- DOI for Functional specialization of hippocampal somatostatin-expressing interneurons
- Download full text (pdf) of Functional specialization of hippocampal somatostatin-expressing interneurons
Part of PLoS biology, 2024
- DOI for Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis
- Download full text (pdf) of Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis
Part of BMC Neuroscience, 2024
- DOI for A flowchart for adequate controls in virus-based monosynaptic tracing experiments identified Cre-independent leakage of the TVA receptor in RΊGT mice
- Download full text (pdf) of A flowchart for adequate controls in virus-based monosynaptic tracing experiments identified Cre-independent leakage of the TVA receptor in RΊGT mice
Part of Progress in Neuro-psychopharmacology and Biological Psychiatry, 2024
- DOI for Unraveling the role of Slc10a4 in auditory processing and sensory motor gating: Implications for neuropsychiatric disorders?
- Download full text (pdf) of Unraveling the role of Slc10a4 in auditory processing and sensory motor gating: Implications for neuropsychiatric disorders?
Part of Pharmacological Research, 2023
- DOI for The alpha2 nicotinic acetylcholine receptor, a subunit with unique and selective expression in inhibitory interneurons associated with principal cells
- Download full text (pdf) of The alpha2 nicotinic acetylcholine receptor, a subunit with unique and selective expression in inhibitory interneurons associated with principal cells
Cortical somatostatin interneuron subtypes form cell-type-specific circuits
Part of Neuron, p. 2675-2692, 2023
Part of Journal of Comparative Neurology, p. 5-24, 2023
- DOI for Adult spinal Dmrt3 neurons receive direct somatosensory inputs from ipsi- and contralateral primary afferents and from brainstem motor nuclei
- Download full text (pdf) of Adult spinal Dmrt3 neurons receive direct somatosensory inputs from ipsi- and contralateral primary afferents and from brainstem motor nuclei
Part of eNeuro, 2022
- DOI for Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26
- Download full text (pdf) of Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26
Part of Frontiers in Cellular Neuroscience, 2021
- DOI for Single cell transcriptomic analysis of spinal Dmrt3 neurons in zebrafish and mouse identifies distinct subtypes and reveal novel subpopulations within the dI6 domain
- Download full text (pdf) of Single cell transcriptomic analysis of spinal Dmrt3 neurons in zebrafish and mouse identifies distinct subtypes and reveal novel subpopulations within the dI6 domain
A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits
Part of PLOS Genetics, 2021
- DOI for A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits
- Download full text (pdf) of A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits
Using Cortical Neuron Markers to Target Cells in the Dorsal Cochlear Nucleus
Part of eNeuro, 2021
- DOI for Using Cortical Neuron Markers to Target Cells in the Dorsal Cochlear Nucleus
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Part of eNeuro, 2020
- DOI for Behavioral Characterization of dmrt3a Mutant Zebrafish Reveals Crucial Aspects of Vertebrate Locomotion through Phenotypes Related to Acceleration
- Download full text (pdf) of Behavioral Characterization of dmrt3a Mutant Zebrafish Reveals Crucial Aspects of Vertebrate Locomotion through Phenotypes Related to Acceleration
Part of Nature Neuroscience, p. 1240-1252, 2020
EphA4 Is Required for Neural Circuits Controlling Skilled Reaching
Part of Journal of Neuroscience, p. 7091-7104, 2020
Part of PLOS Genetics, 2019
- DOI for The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain.
- Download full text (pdf) of The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain.
Part of iScience, p. 246-257, 2019
- DOI for EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions
- Download full text (pdf) of EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions
Part of Hippocampus, p. 1224-1237, 2019
Characterization of Dmrt3-Derived Neurons Suggest a Role within Locomotor Circuits
Part of Journal of Neuroscience, p. 1771-1782, 2019
Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
Part of Nature Communications, 2018
OLM alpha 2 Cells Bidirectionally Modulate Learning
Part of Neuron, p. 404-412, 2018
Part of Life Science Alliance, 2018
- DOI for Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord
- Download full text (pdf) of Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord
Origin and circuitry of spinal locomotor interneurons generating different speeds.
Part of Current Opinion in Neurobiology, p. 16-21, 2018
The MINDVIEW project: First results
Part of European psychiatry, p. 21-27, 2018
Part of Neuroimmunomodulation, p. 220-230, 2017
Part of Scientific Reports, 2017
- DOI for SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo
- Download full text (pdf) of SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo
Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation
Part of PLoS biology, 2017
- DOI for Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation
- Download full text (pdf) of Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation
Part of Journal of Neuroscience, p. 5634-5647, 2017
Identification of a Neuronal Receptor Controlling Anaphylaxis
Part of Cell Reports, p. 370-379, 2016
- DOI for Identification of a Neuronal Receptor Controlling Anaphylaxis
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Multimodal Eph/Ephrin signaling controls several phases of urogenital development
Part of Kidney International, p. 373-388, 2016
On the photovoltaic effect in localfield potential recordings
Part of Neurophotonics, 2016
- DOI for On the photovoltaic effect in localfield potential recordings
- Download full text (pdf) of On the photovoltaic effect in localfield potential recordings
Conditional targeting of medium spiny neurons in the striatal matrix
Part of Frontiers in Behavioral Neuroscience, 2015
- DOI for Conditional targeting of medium spiny neurons in the striatal matrix
- Download full text (pdf) of Conditional targeting of medium spiny neurons in the striatal matrix
Novel markers for OLM interneurons in the hippocampus
Part of Frontiers in Cellular Neuroscience, 2015
- DOI for Novel markers for OLM interneurons in the hippocampus
- Download full text (pdf) of Novel markers for OLM interneurons in the hippocampus
Part of European Journal of Neuroscience, p. 887-898, 2015
Part of PLOS ONE, 2015
- DOI for VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents
- Download full text (pdf) of VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents
Part of European Journal of Neuroscience, p. 316-327, 2015
SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis
Part of Biological Psychiatry, p. 526-536, 2015
Part of Molecular Pharmacology, p. 322-334, 2014
Part of Journal of Neuroscience, p. 5211-5221, 2014
Part of Journal of Neuroscience, p. 14055-14068, 2014
Part of Experimental Neurology, p. 73-81, 2013
Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells
Part of Nature Communications, p. 1438, 2013
Genetic analysis of left-right coordination of locomotion
Part of Frontiers in Bioscience, p. 20-35, 2013
Impaired EphA4 signaling leads to congenital hydronephrosis, renal injury, and hypertension
Part of AM J PHYSIOL-RENAL, 2013
Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model
Part of Journal of Comparative Neurology, p. 1449-1469, 2013
Part of Journal of Neurotrauma, p. 2660-2671, 2012
Targeting VGLUT2 in dopamine neurons affects the brain reward system
Part of European Neuropsychopharmacology, 2012
OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons
Part of Nature Neuroscience, p. 1524-1530, 2012
Part of Developmental Biology, p. 279-289, 2012
Part of Molecular and Cellular Neuroscience, p. 322-332, 2012
Part of European Journal of Neuroscience, p. 527-538, 2012
Part of Pain, p. 1525-1536, 2012
Evaluation of Novel Behavioural Correlates to Electrographic Seizure Activity in Mice
Part of Epilepsia, p. 105-105, 2012
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice
Part of Nature, p. 642-646, 2012
Part of Journal of Neuroscience, p. 12593-12603, 2011
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 5789-5794, 2011
Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation
Part of PLoS Genetics, 2011
Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse
Part of BMC Genomics, p. 614, 2010
Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain
Part of Molecular Pain, p. 77, 2010
Part of Journal of Comparative Neurology, p. 2284-2304, 2010
Part of European Journal of Neuroscience, p. 852-863, 2010
Reduced VGLUT2 expression increases motor neuron viability in Sod1(G93A) mice
Part of Neurobiology of Disease, p. 58-66, 2010
VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch
Part of Neuron, p. 529-542, 2010
VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioural activation
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 389-394, 2010
Part of PLoS biology, 2009
Part of Journal of Neuroscience, p. 15642-15649, 2009
Part of Journal of Neuroscience, p. 2238-2251, 2009
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
Part of Nature Neuroscience, p. 1285-1292, 2009
VGLUT2 is essential in neuronal circuitry of cognitive and emotional behavior
Part of Society for Neuroscience Abstract Viewer and Itinerary Planner, 2008
Part of Development, p. 3281-3290, 2008
Part of Journal of Neurotrauma, p. 959-974, 2008
Generation and characterization of a Gdf1 conditional null allele
Part of Genesis, p. 368-372, 2008
Part of Journal of Neurochemistry, p. 1129-1142, 2007
EphA4-Dependent Axon Guidance Is Mediated by the RacGAP α2-Chimaerin
Part of Neuron, p. 756-767, 2007
Role of glutamate in locomotor rhythm generating neuronal circuitry
Part of Journal of Physiology - Paris, p. 297-303, 2006
Genetic analysis of EphA-dependent signaling mechanisms controlling topographic mapping in vivo
Part of Development, p. 4415-4420, 2006
Part of Journal of Neuroscience, p. 12294-12307, 2006
Genetics moving to neuronal networks
Part of TINS - Trends in Neurosciences, p. 239-247, 2005
Part of Neuron, p. 515-528, 2005
Hippocampal plasticity requires postsynaptic ephrinBs.
Part of Nat Neurosci, p. 33-40, 2004
Central pattern generators deciphered by molecular genetics.
Part of Neuron, p. 317-21, 2004
Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes
Part of Neuron, p. 453-65, 2003
Role of EphA4 and EphrinB3 in local neuronal circuits that control walking
Part of Science, p. 1889-1892, 2003
Mechanisms and functions of Eph and ephrin signalling.
Part of Nat Rev Mol Cell Biol, p. 475-86, 2002
Part of Neuron, p. 73-84, 2001
Part of Genes & Development, p. 877-888, 2001
Part of Journal of Neuroscience, p. 8700-8711, 1998
Part of Cell growth & differentiation, p. 757-766, 1998
Molecular phylogeny and evolution of the neurotrophins from monotremes and marsupials
Part of Journal of Molecular Evolution, p. 311-321, 1997
Specificity of neurotrophin-3 determined by loss-of-function mutagenesis
Part of Journal of Neuroscience Research, p. 496-503, 1997
Part of Journal of Biological Chemistry, p. 9300-9307, 1997
Expression of neurotrophins and trk receptors in the avian retina
Part of Journal of Comparative Neurology, p. 664-676, 1996
Design, synthesis, tandem mass spectrometric sequencing and biological activity of NGF mimetics
Part of International journal of peptide & protein research, p. 337-346, 1996
Neurotrophins and their receptors in chicken neuronal development
Part of International Journal of Developmental Biology, p. 855-868, 1995
Part of European Journal of Neuroscience, p. 116-128, 1995
Articles, review/survey
Cortical disinhibitory circuits: cell types, connectivity and function
Part of TINS - Trends in Neurosciences, p. 643-657, 2021
Lessons, insights and newly developed tools emerging from behavioral phenotyping core facilities
Part of Journal of Neuroscience Methods, 2020
Books
Evolution of the neurotrophins and their receptors
Sulburger & Graham Publishing NY, 1999
Conference papers
Dorsally derived spinal interneurons in locomotor circuits
Part of Neurons, Circuitry, and Plasticity in the Spinal Cord and Brainstem, p. 32-42, 2013
Manuscripts (preprints)
Development of spinal motor circuits in the absence of VIAAT-mediated Renshaw cell signaling
Inhibition of hippocampal OLMα2 cells rescue nicotine induced memory impairment
Hippocampal OLMα2 cells gate basolateral amygdala inputs for threat processing
Conditional genetic labeling of the Renshaw cell population for functional studies of motor control