Globischs grupp

NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Rameika, Natallia; Tsiara, Ioanna; Zhang, Xiaonan; Haberek, Wawrzyniec et al.

Ingår i Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI för NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
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Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine

Lin, Weifeng; Gerullat, Lars; Braadland, Peder R.; Fournier, Anaïs et al.

Ingår i Angewandte Chemie International Edition, 2024

• DOI för Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
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Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain

Vallianatou, Theodosia; de Souza Anselmo, Carina; Tsiara, Ioanna; Bechet, Nicholas B. et al.

Ingår i ACS Chemical Neuroscience, s. 1335-1341, 2024

• DOI för Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
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The protective role of commensal gut microbes and their metabolites against bacterial pathogens

Cheng, Liqin; Correia, Mario S. P.; Higdon, Shawn M.; Garcia, Fabricio Romero et al.

Ingår i Gut microbes, 2024

• DOI för The protective role of commensal gut microbes and their metabolites against bacterial pathogens
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Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug

McCoubrey, Laura E.; Shen, Chenghao; Mwasambu, Sydney; Favaron, Alessia et al.

Ingår i European Journal of Pharmaceutical Sciences, 2024

• DOI för Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Ingår i EBioMedicine, 2024

• DOI för Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken

Bi, Huijuan; Tranell, Jonas; Harper, Dawn C.; Lin, Weifeng et al.

Ingår i PLOS Genetics, 2023

• DOI för A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
• Ladda ner fulltext (pdf) av A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken

Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics

Lin, Weifeng; Mellinghaus, Kiana; Rodriguez-Mateos, Ana; Globisch, Daniel

Ingår i Food Chemistry, 2023

• DOI för Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
• Ladda ner fulltext (pdf) av Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics

Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites

Kaur, Amanpreet; Lin, Weifeng; Dovhalyuk, Vladyslav; Driutti, Léna et al.

Ingår i Chemical Science, s. 5291-5301, 2023

• DOI för Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
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Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers

Nyström, Niklas; Prast-Nielsen, Stefanie; Correia, Mario; Globisch, Daniel et al.

Ingår i Journal of Crohn's & Colitis, s. 418-432, 2023

• DOI för Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers
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Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes

Tsiara, Ioanna; Riemer, Amelie; Correia, Mario S. P.; Rodriguez-Mateos, Ana et al.

Ingår i Analytical Chemistry, s. 12565-12571, 2023

• DOI för Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
• Ladda ner fulltext (pdf) av Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes

Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures

Lin, Weifeng; Garcia, Fabricio Romero; Norin, Elisabeth Lissa; Kart, Didem et al.

Ingår i Chemical Communications, s. 5843-5846, 2023

• DOI för Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures

Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors

Joffré, Enrique; Xiao, Xue; Correia, Mário S. P.; Nookaew, Intawat et al.

Ingår i Microbiology Spectrum, 2022

• DOI för Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors
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Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle

Vallianatou, Theodosia; Bechet, Nicholas B.; Correia, Mario S. P.; Lundgaard, Iben et al.

Ingår i Metabolites, 2022

• DOI för Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle
• Ladda ner fulltext (pdf) av Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle

Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Zhang, Xiaonan; Akcan, Ece; Correia, Mario S. P.; Rameika, Natallia et al.

Ingår i Biochemical Pharmacology, 2022

• DOI för Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
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Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep

Vallianatou, Theodosia; Lin, Weifeng; Bèchet, Nicholas B; Correia, Mario SP et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 3324-3338, 2021

• DOI för Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
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Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites

Lin, Weifeng; Conway, Louis P.; Vujasinovic, Miroslav; Löhr, J.‐Matthias et al.

Ingår i Angewandte Chemie International Edition, s. 23232-23240, 2021

• DOI för Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
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Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

Lin, Weifeng; Yang, Zhen; Kaur, Amanpreet; Block, Annika et al.

Ingår i RSC CHEMICAL BIOLOGY, s. 1479-1483, 2021

• DOI för Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines
• Ladda ner fulltext (pdf) av Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P. et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2021

• DOI för Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
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Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency

Correia, Mario S. P.; Thapa, Bhawana; Vujasinovic, Miroslav; Löhr, J.-Matthias et al.

Ingår i RSC Advances, s. 34788-34794, 2021

• DOI för Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency
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Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites

Jain, Abhishek; Correia, Mario S. P.; Meistermann, Hannes; Vujasinovic, Miroslav et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2021

• DOI för Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites
• Ladda ner fulltext (pdf) av Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites

Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples

Correia, Mario S. P.; Lin, Weifeng; Aria, Arash J.; Jain, Abhishek et al.

Ingår i Metabolites, 2020

• DOI för Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples
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Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification

Lin, Weifeng; Conway, Louis P.; Block, Annika; Sommi, Greta et al.

Ingår i The Analyst, s. 3822-3831, 2020

• DOI för Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
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Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host

Correia, Mario S. P.; Jain, Abhishek; Alotaibi, Wafa; Yang, Paul Young Tie et al.

Ingår i Free Radical Biology & Medicine, s. 745-754, 2020

• DOI för Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host
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Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World

Nainyte, Milda; Müller, Felix; Ganazzoli, Giacomo; Chan, Chun-Yin et al.

Ingår i Chemistry - A European Journal, s. 14856-14860, 2020

• DOI för Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World
• Ladda ner fulltext (pdf) av Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2

Conway, Louis P.; Rendo, Verónica; Correia, Mario S. P.; Bergdahl, Ingvar A et al.

Ingår i Angewandte Chemie International Edition, s. 14342-14346, 2020

• DOI för Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
• Ladda ner fulltext (pdf) av Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2

DNA surface exploration and operator bypassing during target search

Marklund, Emil; van Oosten, Brad; Mao, Guanzhong; Amselem, Elias et al.

Ingår i Nature, s. 858-+, 2020

• DOI för DNA surface exploration and operator bypassing during target search
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Coupled Enzymatic Treatment and Mass Spectrometric Analysis for Identification of Glucuronidated Metabolites in Human Samples

Correia, Mario S. P.; Rao, Menghua; Ballet, Caroline; Globisch, Daniel

Ingår i ChemBioChem, s. 1678-1683, 2019

• DOI för Coupled Enzymatic Treatment and Mass Spectrometric Analysis for Identification of Glucuronidated Metabolites in Human Samples

Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples

Conway, Louis P.; Garg, Neeraj; Lin, Weifeng; Vujasinovic, Miroslav et al.

Ingår i Chemical Communications, s. 9080-9083, 2019

• DOI för Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
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Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry

Correia, Mário S. P.; Ballet, Caroline; Meistermann, Hannes; Conway, Louis P. et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 955-962, 2019

• DOI för Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry

Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control

Garg, Neeraj; Hansson, Annelie; Knych, Heather K.; Stanley, Scott D. et al.

Ingår i Organic and biomolecular chemistry, s. 698-702, 2018

• DOI för Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control

Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis

Shirey, Ryan J.; Globisch, Daniel; Eubanks, Lisa M.; Hixon, Mark S. et al.

Ingår i ACS - Infectious Diseases, s. 1423-1431, 2018

• DOI för Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
• Ladda ner fulltext (pdf) av Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis

New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites

Ballet, Caroline; Correia, Mario S. P.; Conway, Louis P.; Locher, Theresa L. et al.

Ingår i Chemical Science, s. 6233-6239, 2018

• DOI för New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
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Chemoselective Probe Containing a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism

Garg, Neeraj; Conway, Louis P.; Ballet, Caroline; Correia, Mario S. P. et al.

Ingår i Angewandte Chemie International Edition, s. 13805-13809, 2018

• DOI för Chemoselective Probe Containing a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism

Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)

Globisch, Daniel; Eubanks, Lisa M.; Shirey, Ryan J.; Pfarr, Kenneth M. et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 3436-3440, 2017

• DOI för Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)

Effect of Antibiotic Treatment on the Gut Metabolome of Pigs

Mwasambu, Sydney; Giakoumis, Theodoros; Kořínek, Jan; O'Shea, Joey et al.

Effect of Antibiotic Treatment on the Gut Metabolome of Pigs

Mwasambu, Sydney; Giakoumis, Theodoros; Kořínek, Jan; O'Shea, Joey et al.

Novel anti-cancer agents targeting NAT2 loss in colorectal cancer

Rameika, Natallia; Tsiara, Ioanna; Haberek, Wawrzyniec; Akcan, Ece et al.