Ivarssons grupp

Molekylär igenkänning i cellsignalering
Vår forskning fokuserar på interaktioner mellan korta bindningsmotiv som finns i de ostrukturerade delarna av vårt proteom och de peptidbindande proteindomäner som känner igen och binder till dem. Forskningen syftar till att ge nya kunskaper om de nätverk av protein-protein interaktioner som är verksamma i signalöverföringsvägar i friska och sjuka celler. Vår forskning är tvärvetenskaplig och kombinerar biokemiska och biofysikaliska metoder med bioinformatik och cellbaserade försök.
Gruppmedlemmar
Publikationer
Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD
Ingår i Biochemical and Biophysical Research Communications - BBRC, 2024
Ingår i Structure, 2024
Ingår i Nature Communications, 2024
- DOI för ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
- Ladda ner fulltext (pdf) av ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
Ingår i Molecular Systems Biology, s. 1025-1048, 2024
- DOI för Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
- Ladda ner fulltext (pdf) av Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
Ingår i Analytical Biochemistry, 2023
- DOI för Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions
- Ladda ner fulltext (pdf) av Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions
SLiM-binding pockets: an attractive target for broad-spectrum antivirals
Ingår i TIBS -Trends in Biochemical Sciences. Regular ed., s. 420-427, 2023
- DOI för SLiM-binding pockets: an attractive target for broad-spectrum antivirals
- Ladda ner fulltext (pdf) av SLiM-binding pockets: an attractive target for broad-spectrum antivirals
Ingår i Current opinion in structural biology, 2023
- DOI för The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome
- Ladda ner fulltext (pdf) av The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome
Ingår i Nature Communications, 2023
- DOI för Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets
- Ladda ner fulltext (pdf) av Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets
Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions
Ingår i Molecular Systems Biology, 2023
Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase
Ingår i Nature Chemical Biology, s. 1423-1431, 2023
Ingår i Biochemistry, s. 1594-1607, 2023
- DOI för Elucidation of Short Linear Motif-Based Interactions of the FERM Domains of Ezrin, Radixin, Moesin, and Merlin
- Ladda ner fulltext (pdf) av Elucidation of Short Linear Motif-Based Interactions of the FERM Domains of Ezrin, Radixin, Moesin, and Merlin
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Ingår i Nature Communications, 2023
- DOI för Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
- Ladda ner fulltext (pdf) av Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Ingår i Biochemical Journal, s. 1-22, 2022
- DOI för p Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs
- Ladda ner fulltext (pdf) av p Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs
How viral proteins bind short linear motifs and intrinsically disordered domains
Ingår i Essays in Biochemistry, s. 935-944, 2022
ProP-PD for proteome-wide motif-mediated interaction discovery
Ingår i TIBS -Trends in Biochemical Sciences. Regular ed., s. 547-548, 2022
- DOI för ProP-PD for proteome-wide motif-mediated interaction discovery
- Ladda ner fulltext (pdf) av ProP-PD for proteome-wide motif-mediated interaction discovery
Proteome-scale mapping of binding sites in the unstructured regions of the human proteome
Ingår i Molecular Systems Biology, 2022
- DOI för Proteome-scale mapping of binding sites in the unstructured regions of the human proteome
- Ladda ner fulltext (pdf) av Proteome-scale mapping of binding sites in the unstructured regions of the human proteome
Ingår i eLIFE, 2022
- DOI för Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition
- Ladda ner fulltext (pdf) av Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition
A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses
Ingår i Viruses, 2022
- DOI för A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses
- Ladda ner fulltext (pdf) av A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses
Ingår i Science Signaling, 2021
A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma
Ingår i Journal of Medicinal Chemistry, s. 1423-1434, 2021
Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs
Ingår i Current Research in Structural Biology, s. 41-50, 2021
- DOI för Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs
- Ladda ner fulltext (pdf) av Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs
Ingår i Nature Communications, 2021
- DOI för Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
- Ladda ner fulltext (pdf) av Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
Genetically Encoded Cyclic Peptide Phage Display Libraries
Ingår i ACS CENTRAL SCIENCE, s. 336-338, 2020
- DOI för Genetically Encoded Cyclic Peptide Phage Display Libraries
- Ladda ner fulltext (pdf) av Genetically Encoded Cyclic Peptide Phage Display Libraries
Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling
Ingår i Molecular Cell, s. 342-+, 2020
Ingår i Journal of Molecular Biology, s. 5920-5937, 2020
Ingår i Biochimica et Biophysica Acta - General Subjects, 2020
Editorial overview: Folding and binding
Ingår i Current opinion in structural biology, s. 139-140, 2019
Systematic identification of recognition motifs for the hub protein LC8
Ingår i Life Science Alliance, 2019
- DOI för Systematic identification of recognition motifs for the hub protein LC8
- Ladda ner fulltext (pdf) av Systematic identification of recognition motifs for the hub protein LC8
Affinity and specificity of motif-based protein-protein interactions
Ingår i Current opinion in structural biology, s. 26-33, 2019
- DOI för Affinity and specificity of motif-based protein-protein interactions
- Ladda ner fulltext (pdf) av Affinity and specificity of motif-based protein-protein interactions
A Consensus Binding Motif for the PP4 Protein Phosphatase
Ingår i Molecular Cell, s. 953-964000000, 2019
Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
Ingår i Molecular Systems Biology, 2018
- DOI för Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
- Ladda ner fulltext (pdf) av Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
High-throughput discovery of functional disordered regions
Ingår i Molecular Systems Biology, 2018
Ingår i Biochemistry, s. 66-71, 2018
- DOI för The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1
- Ladda ner fulltext (pdf) av The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1
Ingår i The FEBS Journal, s. 485-498, 2017
- DOI för Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome
- Ladda ner fulltext (pdf) av Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome
Uncovering Novel Substrates and Functions for the Calcineurin Phosphatase in Human Cells
Ingår i The FASEB Journal, 2017
Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017
Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017
A novel role for the Calcineurin phosphatase at the nuclear pore
Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017
PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis
Ingår i Cell Discovery, 2017
- DOI för PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis
- Ladda ner fulltext (pdf) av PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis
Ingår i Proteomes, 2016
Uncovering novel substrates and functions for the calcineurin phosphatase in human cells.
Ingår i Molecular Biology of the Cell, 2016
Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin
Ingår i FEBS Letters, s. 3-12, 2016
- DOI för Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin
- Ladda ner fulltext (pdf) av Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin
Pooled screening for antiproliferative inhibitors of protein-protein interactions.
Ingår i Nature Chemical Biology, s. 275-281, 2016
Ingår i Scientific Reports, 2016
- DOI för Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions.
- Ladda ner fulltext (pdf) av Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions.
Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling
Ingår i Nature Communications, 2016
- DOI för Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling
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Selectivity of Aggregation-Determining Interactions
Ingår i Journal of Molecular Biology, s. 236-247, 2015
Structural basis of Sorcin-mediated calcium-dependent signal transduction
Ingår i Scientific Reports, 2015
Ingår i Cell Communication and Signaling, 2015
- DOI för High-throughput methods for identification of protein-protein interactions involving short linear motifs
- Ladda ner fulltext (pdf) av High-throughput methods for identification of protein-protein interactions involving short linear motifs
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 2542-2547, 2014
Interaction Analysis through Proteomic Phage Display
Ingår i BioMed Research International, s. 176172, 2014
- DOI för Interaction Analysis through Proteomic Phage Display
- Ladda ner fulltext (pdf) av Interaction Analysis through Proteomic Phage Display