Ylva Ivarsson
Professor i biokemi vid Institutionen för kemi - BMC; Biokemi; Ivarsson grupp
- Telefon:
- 018-471 40 38
- E-post:
- Ylva.Ivarsson@kemi.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 576
75123 Uppsala
- Akademiska meriter:
- FD, docent i biokemi
Kort presentation
Ylva Ivarsson is a full professor of Biochemistry with a research team funded by the Swedish Research Council, the Swedish foundation for strategic research, EU Marie Curie ITN and others. The research of the group is interdisciplinary and combines biochemical and biophysical methods with bioinformatics and cell-based assays to study motif-based protein-protein interactions.
Visit the homepage of the group for more information
https://ivarssonlab.com/

Publikationer
Senaste publikationer
Ingår i Nature Communications, 2024
- DOI för ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
- Ladda ner fulltext (pdf) av ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
Ingår i Molecular Systems Biology, s. 1025-1048, 2024
- DOI för Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
- Ladda ner fulltext (pdf) av Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD
Ingår i Biochemical and Biophysical Research Communications - BBRC, 2024
Ingår i Structure, 2024
Ingår i Analytical Biochemistry, 2023
- DOI för Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions
- Ladda ner fulltext (pdf) av Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions
Alla publikationer
Artiklar i tidskrift
Ingår i Nature Communications, 2024
- DOI för ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
- Ladda ner fulltext (pdf) av ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
Ingår i Molecular Systems Biology, s. 1025-1048, 2024
- DOI för Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
- Ladda ner fulltext (pdf) av Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD
Ingår i Biochemical and Biophysical Research Communications - BBRC, 2024
Ingår i Structure, 2024
Ingår i Analytical Biochemistry, 2023
- DOI för Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions
- Ladda ner fulltext (pdf) av Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions
Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions
Ingår i Molecular Systems Biology, 2023
Ingår i Nature Communications, 2023
- DOI för Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets
- Ladda ner fulltext (pdf) av Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets
Ingår i Biochemistry, s. 1594-1607, 2023
- DOI för Elucidation of Short Linear Motif-Based Interactions of the FERM Domains of Ezrin, Radixin, Moesin, and Merlin
- Ladda ner fulltext (pdf) av Elucidation of Short Linear Motif-Based Interactions of the FERM Domains of Ezrin, Radixin, Moesin, and Merlin
Ingår i Current opinion in structural biology, 2023
- DOI för The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome
- Ladda ner fulltext (pdf) av The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Ingår i Nature Communications, 2023
- DOI för Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
- Ladda ner fulltext (pdf) av Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase
Ingår i Nature Chemical Biology, s. 1423-1431, 2023
ProP-PD for proteome-wide motif-mediated interaction discovery
Ingår i TIBS -Trends in Biochemical Sciences. Regular ed., s. 547-548, 2022
- DOI för ProP-PD for proteome-wide motif-mediated interaction discovery
- Ladda ner fulltext (pdf) av ProP-PD for proteome-wide motif-mediated interaction discovery
Proteome-scale mapping of binding sites in the unstructured regions of the human proteome
Ingår i Molecular Systems Biology, 2022
- DOI för Proteome-scale mapping of binding sites in the unstructured regions of the human proteome
- Ladda ner fulltext (pdf) av Proteome-scale mapping of binding sites in the unstructured regions of the human proteome
A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses
Ingår i Viruses, 2022
- DOI för A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses
- Ladda ner fulltext (pdf) av A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses
Ingår i eLIFE, 2022
- DOI för Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition
- Ladda ner fulltext (pdf) av Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition
Ingår i Nature Communications, 2021
- DOI för Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
- Ladda ner fulltext (pdf) av Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
Ingår i Science Signaling, 2021
Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs
Ingår i Current Research in Structural Biology, s. 41-50, 2021
- DOI för Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs
- Ladda ner fulltext (pdf) av Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs
A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma
Ingår i Journal of Medicinal Chemistry, s. 1423-1434, 2021
Ingår i Journal of Molecular Biology, s. 5920-5937, 2020
Genetically Encoded Cyclic Peptide Phage Display Libraries
Ingår i ACS CENTRAL SCIENCE, s. 336-338, 2020
- DOI för Genetically Encoded Cyclic Peptide Phage Display Libraries
- Ladda ner fulltext (pdf) av Genetically Encoded Cyclic Peptide Phage Display Libraries
Ingår i Biochimica et Biophysica Acta - General Subjects, 2020
Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling
Ingår i Molecular Cell, s. 342-+, 2020
Systematic identification of recognition motifs for the hub protein LC8
Ingår i Life Science Alliance, 2019
- DOI för Systematic identification of recognition motifs for the hub protein LC8
- Ladda ner fulltext (pdf) av Systematic identification of recognition motifs for the hub protein LC8
A Consensus Binding Motif for the PP4 Protein Phosphatase
Ingår i Molecular Cell, s. 953-964000000, 2019
Editorial overview: Folding and binding
Ingår i Current opinion in structural biology, s. 139-140, 2019
Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
Ingår i Molecular Systems Biology, 2018
- DOI för Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
- Ladda ner fulltext (pdf) av Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
High-throughput discovery of functional disordered regions
Ingår i Molecular Systems Biology, 2018
Ingår i Biochemistry, s. 66-71, 2018
- DOI för The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1
- Ladda ner fulltext (pdf) av The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1
Ingår i The FEBS Journal, s. 485-498, 2017
- DOI för Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome
- Ladda ner fulltext (pdf) av Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome
PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis
Ingår i Cell Discovery, 2017
- DOI för PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis
- Ladda ner fulltext (pdf) av PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis
A novel role for the Calcineurin phosphatase at the nuclear pore
Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017
Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017
Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017
Uncovering Novel Substrates and Functions for the Calcineurin Phosphatase in Human Cells
Ingår i The FASEB Journal, 2017
Pooled screening for antiproliferative inhibitors of protein-protein interactions.
Ingår i Nature Chemical Biology, s. 275-281, 2016
Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin
Ingår i FEBS Letters, s. 3-12, 2016
- DOI för Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin
- Ladda ner fulltext (pdf) av Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin
Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling
Ingår i Nature Communications, 2016
- DOI för Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling
- Ladda ner fulltext (pdf) av Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling
Ingår i Scientific Reports, 2016
- DOI för Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions.
- Ladda ner fulltext (pdf) av Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions.
Uncovering novel substrates and functions for the calcineurin phosphatase in human cells.
Ingår i Molecular Biology of the Cell, 2016
Selectivity of Aggregation-Determining Interactions
Ingår i Journal of Molecular Biology, s. 236-247, 2015
Structural basis of Sorcin-mediated calcium-dependent signal transduction
Ingår i Scientific Reports, 2015
A Structural Portrait of the PDZ Domain Family
Ingår i Journal of Molecular Biology, s. 3509-3519, 2014
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 2542-2547, 2014
Ingår i Journal of Peptide Science, 2014
Ingår i PLOS ONE, 2013
Ingår i PloS one, 2013
Ingår i FEBS Letters, s. 1445-1451, 2012
Plasticity of PDZ domains in ligand recognition and signaling
Ingår i FEBS Letters, s. 2638-47, 2012
Ingår i Journal of Cell Science, s. 1129-1140, 2012
Syndecan-syntenin-ALIX regulates the biogenesis of exosomes
Ingår i Nature cell biology, s. 677-685, 2012
Ingår i Journal of Biological Chemistry, s. 44669-78, 2011
Ingår i Nature medicine, s. 720-725, 2011
Structural diversity of PDZ-lipid interactions
Ingår i ChemBioChem, s. 456-67, 2010
Ingår i Nature Structural & Molecular Biology, s. 1431-1437, 2010
Folding and stability of globular proteins and implications for function
Ingår i Current opinion in structural biology, s. 3-7, 2009
Ingår i Journal of the American Chemical Society, s. 11727-33, 2009
Folding and misfolding in a naturally occurring circularly permuted PDZ domain
Ingår i Journal of Biological Chemistry, s. 8954-60, 2008
Ingår i European Biophysics Journal, s. 721-728, 2008
The folding pathway of an engineered circularly permuted PDZ domain
Ingår i Protein Engineering Design & Selection, s. 155-160, 2008
Ingår i Biochimica et Biophysica Acta - General Subjects, s. 1374-1381, 2007
An on-pathway intermediate in the folding of a PDZ domain
Ingår i Journal of Biological Chemistry, s. 8568-8572, 2007
Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics
Ingår i Biophysical Chemistry, s. 111-114, 2007
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 4876-4881, 2006
Ingår i Protein Engineering Design and Selection, s. 607-616, 2006
Ingår i Proceedings of the National Academy of Sciences of the USA, s. 4876-4881, 2006
Ingår i FEBS Journal, 2005
Ingår i Protein Eng Des Sel, s. 607-16, 2005
Ingår i Journal of Biological Chemistry, s. 8733-8738, 2003
Artiklar, forskningsöversikt
SLiM-binding pockets: an attractive target for broad-spectrum antivirals
Ingår i TIBS -Trends in Biochemical Sciences. Regular ed., s. 420-427, 2023
- DOI för SLiM-binding pockets: an attractive target for broad-spectrum antivirals
- Ladda ner fulltext (pdf) av SLiM-binding pockets: an attractive target for broad-spectrum antivirals
Ingår i Biochemical Journal, s. 1-22, 2022
- DOI för p Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs
- Ladda ner fulltext (pdf) av p Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs
How viral proteins bind short linear motifs and intrinsically disordered domains
Ingår i Essays in Biochemistry, s. 935-944, 2022
Affinity and specificity of motif-based protein-protein interactions
Ingår i Current opinion in structural biology, s. 26-33, 2019
- DOI för Affinity and specificity of motif-based protein-protein interactions
- Ladda ner fulltext (pdf) av Affinity and specificity of motif-based protein-protein interactions
Ingår i Proteomes, 2016
Ingår i Cell Communication and Signaling, 2015
- DOI för High-throughput methods for identification of protein-protein interactions involving short linear motifs
- Ladda ner fulltext (pdf) av High-throughput methods for identification of protein-protein interactions involving short linear motifs
Interaction Analysis through Proteomic Phage Display
Ingår i BioMed Research International, s. 176172, 2014
- DOI för Interaction Analysis through Proteomic Phage Display
- Ladda ner fulltext (pdf) av Interaction Analysis through Proteomic Phage Display
Identification and characterization of protein folding intermediates
Ingår i Biophysical Chemistry, s. 105-113, 2007
Kapitel i böcker, delar av antologi
Ingår i Toxicology of Glutathione Transferases, s. 47-69, CRC Taylor & Francis, Boca Raton, 2006