Sengers grupp

Beyond Canonical CO Oxidation: First Characterisation of a Clade B CODH using a New Anaerobic Cryo-EM Workflow

Böhm, Maximilian; Srinivas, Vivek; Wiseman, Benjamin; Huang, Ping et al.

2026

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Probing the Influence of the Protein Scaffold on H-Cluster Reactivity via Gain-of-Function Studies─Improved H₂ Evolution and O₂ Tolerance through Rational Design of [FeFe] Hydrogenase

Cabotaje, Princess R.; Sekretareva, Alina; Senger, Moritz; Huang, Ping et al.

Ingår i Journal of the American Chemical Society, s. 4654-4666, 2025

• DOI för Probing the Influence of the Protein Scaffold on H-Cluster Reactivity via Gain-of-Function Studies─Improved H₂ Evolution and O₂ Tolerance through Rational Design of [FeFe] Hydrogenase
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Indications for a universal hydrogen catalysis mechanism in [FeFe]-hydrogenases of different phylogenetic groups

Senger, Moritz; Schumann, Conrad; Cabotaje, Princess R.; Zamader, Afridi et al.

Ingår i Physical Chemistry, Chemical Physics - PCCP, s. 9864-9875, 2025

• DOI för Indications for a universal hydrogen catalysis mechanism in [FeFe]-hydrogenases of different phylogenetic groups
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Reconsidering the Enzyme Kinetics of [FeFe]-Hydrogenases: Improved Turnover Rates and New Insights into pH and Potential Dependence with Eu(II)-Based Solution Assays

Sönmez, Eda; Kostopoulos, Nikolaos; Gamache, Mira; Cheah, Mun Hon et al.

Ingår i Analytical Chemistry, s. 26393-26403, 2025

• DOI för Reconsidering the Enzyme Kinetics of [FeFe]-Hydrogenases: Improved Turnover Rates and New Insights into pH and Potential Dependence with Eu(II)-Based Solution Assays
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Secondary structure changes as the potential H₂ sensing mechanism of group D [FeFe]-hydrogenases

Voloshyn, Ivan; Schumann, Conrad; Cabotaje, Princess R.; Zamader, Afridi et al.

Ingår i Chemical Communications, s. 10914-10917, 2024

• DOI för Secondary structure changes as the potential H₂ sensing mechanism of group D [FeFe]-hydrogenases
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Minimal and hybrid hydrogenases are active from archaea

Greening, Chris; Cabotaje, Princess R.; Valentin Alvarado, Luis E.; Leung, Pok Man et al.

Ingår i Cell, 2024

• DOI för Minimal and hybrid hydrogenases are active from archaea
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Structural basis for bacterial energy extraction from atmospheric hydrogen

Grinter, Rhys; Kropp, Ashleigh; Venugopal, Hari; Senger, Moritz et al.

Ingår i Nature, s. 541-547, 2023

• DOI för Structural basis for bacterial energy extraction from atmospheric hydrogen
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Elucidating Electron Transfer Kinetics and Optimizing System Performance for Escherichia coli-Based Semi-Artificial H-2 Production

Gamache, Mira T.; Charaf, Rima; Kurth, Larissa; Filmon, Dawit T. et al.

Ingår i ACS Catalysis, s. 9476-9486, 2023

• DOI för Elucidating Electron Transfer Kinetics and Optimizing System Performance for Escherichia coli-Based Semi-Artificial H-2 Production
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Probing Substrate Transport Effects on Enzymatic Hydrogen Catalysis: An Alternative Proton Transfer Pathway in Putatively Sensory [FeFe] Hydrogenase

Cabotaje, Princess R.; Walter, Kaija; Zamader, Afridi; Huang, Ping et al.

Ingår i ACS Catalysis, s. 10435-10446, 2023

• DOI för Probing Substrate Transport Effects on Enzymatic Hydrogen Catalysis: An Alternative Proton Transfer Pathway in Putatively Sensory [FeFe] Hydrogenase
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Polymer Dots as Photoactive Membrane Vesicles for [FeFe]-Hydrogenase Self-Assembly and Solar-Driven Hydrogen Evolution

Pavliuk, Mariia V.; Lorenzi, Marco; Morado, Dustin R.; Gedda, Lars et al.

Ingår i Journal of the American Chemical Society, s. 13600-13611, 2022

• DOI för Polymer Dots as Photoactive Membrane Vesicles for [FeFe]-Hydrogenase Self-Assembly and Solar-Driven Hydrogen Evolution
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Trapping an Oxidized and Protonated Intermediate of the [FeFe]-Hydrogenase Cofactor under Mildly Reducing Conditions

Senger, Moritz; Duan, Jifu; Pavliuk, Mariia V.; Apfel, Ulf-Peter et al.

Ingår i Inorganic Chemistry, s. 10036-10042, 2022

• DOI för Trapping an Oxidized and Protonated Intermediate of the [FeFe]-Hydrogenase Cofactor under Mildly Reducing Conditions

Hydride state accumulation in native [FeFe]-hydrogenase with the physiological reductant H-2 supports its catalytic relevance

Senger, Moritz; Kernmayr, Tobias; Lorenzi, Marco; Redman, Holly J. et al.

Ingår i Chemical Communications, s. 7184-7187, 2022

• DOI för Hydride state accumulation in native [FeFe]-hydrogenase with the physiological reductant H-2 supports its catalytic relevance
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Light-Driven [FeFe] Hydrogenase Based H-2 Production in E. coli: A Model Reaction for Exploring E. coli Based Semiartificial Photosynthetic Systems

Lorenzi, Marco; Gamache, Mira T.; Redman, Holly J.; Land, Henrik et al.

Ingår i ACS Sustainable Chemistry and Engineering, s. 10760-10767, 2022

• DOI för Light-Driven [FeFe] Hydrogenase Based H-2 Production in E. coli: A Model Reaction for Exploring E. coli Based Semiartificial Photosynthetic Systems
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Investigating the role of the strong field ligands in [FeFe] hydrogenase: spectroscopic and functional characterization of a semi-synthetic mono-cyanide active site

Lorenzi, Marco; Gellett, Joe; Zamader, Afridi; Senger, Moritz et al.

Ingår i Chemical Science, s. 11058-11064, 2022

• DOI för Investigating the role of the strong field ligands in [FeFe] hydrogenase: spectroscopic and functional characterization of a semi-synthetic mono-cyanide active site
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Photosynthetic hydrogen production: Novel protocols, promising engineering approaches and application of semi‐synthetic hydrogenases

Kosourov, Sergey; Böhm, Maximilian; Senger, Moritz; Berggren, Gustav et al.

Ingår i Physiologia Plantarum, s. 555-567, 2021

• DOI för Photosynthetic hydrogen production: Novel protocols, promising engineering approaches and application of semi‐synthetic hydrogenases
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Site-selective protonation of the one-electron reduced cofactor in [FeFe]-hydrogenase

Laun, Konstantin; Baranova, Iuliia; Duan, Jifu; Kertess, Leonie et al.

Ingår i Dalton Transactions, s. 3641-3650, 2021

• DOI för Site-selective protonation of the one-electron reduced cofactor in [FeFe]-hydrogenase
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Current State of [FeFe]-Hydrogenase Research: Biodiversity and Spectroscopic Investigations

Land, Henrik; Senger, Moritz; Berggren, Gustav; Stripp, Sven T.

Ingår i ACS Catalysis, s. 7069-7086, 2020

• DOI för Current State of [FeFe]-Hydrogenase Research: Biodiversity and Spectroscopic Investigations

Characterization of a putative sensory [FeFe]-hydrogenase provides new insight into the role of the active site architecture

Land, Henrik; Sekretaryova, Alina N.; Huang, Ping; Redman, Holly J. et al.

Ingår i Chemical Science, s. 12789-12801, 2020

• DOI för Characterization of a putative sensory [FeFe]-hydrogenase provides new insight into the role of the active site architecture
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[FeFe]-hydrogenase maturation: H-cluster assembly intermediates tracked by electron paramagnetic resonance, infrared, and X-ray absorption spectroscopy

Németh, Brigitta; Senger, Moritz; Redman, Holly J.; Ceccaldi, Pierre et al.

Ingår i Journal of Biological Inorganic Chemistry, s. 777-788, 2020

• DOI för [FeFe]-hydrogenase maturation: H-cluster assembly intermediates tracked by electron paramagnetic resonance, infrared, and X-ray absorption spectroscopy
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