Lars Lannfelt

Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ₄₂/Aβ₄₀ ratios, neurofilament light and tau in Alzheimer’s disease model micece

Andersson, Emelie; Lindblom, Nils; Janelidze, Shorena; Salvadó, Gemma et al.

Part of Nature Aging, p. 366-375, 2025

• DOI for Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ₄₂/Aβ₄₀ ratios, neurofilament light and tau in Alzheimer’s disease model micece
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Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains

Johannesson, Malin; Soderberg, Linda; Zachrisson, Olof; Fritz, Nicolas et al.

Part of Molecular and Cellular Neuroscience, 2024

• DOI for Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
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Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice

Rizoska, Biljana; Zachrisson, Olof; Appelkvist, Paulina; Boström, Emma et al.

Part of Molecular and Cellular Neuroscience, 2024

• DOI for Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
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Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities

Söderberg, Linda; Johannesson, Malin; Gkanatsiou, Eleni; Nygren, Patrik et al.

Part of Scientific Reports, 2024

• DOI for Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Part of Acta neuropathologica communications, 2024

• DOI for Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
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Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ₄₂/Aβ₄₀ ratios, neurofilament light and tau in Alzheimer’s disease model micece

Andersson, Emelie; Lindblom, Nils; Janelidze, Shorena; Salvadó, Gemma et al.

Part of Nature Aging, p. 366-375, 2025

• DOI for Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ₄₂/Aβ₄₀ ratios, neurofilament light and tau in Alzheimer’s disease model micece
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Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains

Johannesson, Malin; Soderberg, Linda; Zachrisson, Olof; Fritz, Nicolas et al.

Part of Molecular and Cellular Neuroscience, 2024

• DOI for Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
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Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice

Rizoska, Biljana; Zachrisson, Olof; Appelkvist, Paulina; Boström, Emma et al.

Part of Molecular and Cellular Neuroscience, 2024

• DOI for Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
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Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities

Söderberg, Linda; Johannesson, Malin; Gkanatsiou, Eleni; Nygren, Patrik et al.

Part of Scientific Reports, 2024

• DOI for Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Part of Acta neuropathologica communications, 2024

• DOI for Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
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Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease

Söderberg, Linda; Johannesson, Malin; Nygren, Patrik; Laudon, Hanna et al.

Part of Neurotherapeutics, p. 195-206, 2023

• DOI for Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease
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Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils

Ekmark-Lewén, Sara; Aniszewska, Agata; Molisak, Agnieszka; Gumucio, Astrid et al.

Part of AGING BRAIN, 2023

• DOI for Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils
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The amyloid-beta pathway in Alzheimer's disease: a plain language summary

Hampel, Harald; Hu, Yan; Hardy, John; Blennow, Kaj et al.

Part of Neurodegenerative Disease Management, p. 141-149, 2023

• DOI for The amyloid-beta pathway in Alzheimer's disease: a plain language summary
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Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia

Pagnon de la Vega, María; Näslund, Carl; Brundin, RoseMarie; Lannfelt, Lars et al.

Part of BMC Genomics, 2022

• DOI for Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia
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A beta and tau prions feature in the neuropathogenesis of Down syndrome

Condello, Carlo; Maxwell, Alison M.; Castillo, Erika; Aoyagi, Atsushi et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI for A beta and tau prions feature in the neuropathogenesis of Down syndrome

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken et al.

Part of Translational Neurodegeneration, 2021

• DOI for Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
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ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease

Nordström, Eva; Eriksson, Fredrik; Sigvardson, Jessica; Johannesson, Malin et al.

Part of Neurobiology of Disease, 2021

• DOI for ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease
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Characterization of monomeric and soluble aggregated A beta in Down's syndrome and Alzheimer's disease brains

Gkanatsiou, Eleni; Stenh, Charlotte; Portelius, Erik; Johannesson, Malin et al.

Part of Neuroscience Letters, 2021

• DOI for Characterization of monomeric and soluble aggregated A beta in Down's syndrome and Alzheimer's disease brains
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Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease

Johannesson, Malin; Sahlin, Charlotte; Söderberg, Linda; Basun, Hans et al.

Part of Molecular and Cellular Neuroscience, 2021

• DOI for Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Part of Science Translational Medicine, 2021

• DOI for The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease

Zhang, Xiao; O'Callaghan, Paul; Li, Honglian; Tan, Ying-Xia et al.

Part of Acta neuropathologica communications, 2021

• DOI for Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease
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A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-A beta protofibril antibody

Swanson, Chad J.; Zhang, Yong; Dhadda, Shobha; Wang, Jinping et al.

Part of Alzheimer's Research & Therapy, 2021

• DOI for A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-A beta protofibril antibody
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Alzheimers sjukdom – diagnostik och behandling i dag och i framtiden

Bogdanovic, Nenad; Hansson, Oskar; Zetterberg, Henrik; Basun, Hans et al.

Part of Läkartidningen, 2020

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.

Surendran, Praveen; Feofanova, Elena V; Lahrouchi, Najim; Ntalla, Ioanna et al.

Part of Nature Genetics, p. 1314-1332, 2020

• DOI for Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.

Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

Danielsson, Marcus; Halvardson, Jonatan; Davies, Hanna; Moghadam, Behrooz Torabi et al.

Part of European Journal of Human Genetics, p. 349-357, 2020

• DOI for Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
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Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

Syvänen, Stina; Fang, Xiaotian T.; Faresjö, Rebecca; Rokka, Johanna et al.

Part of ACS Chemical Neuroscience, p. 4460-4468, 2020

• DOI for Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
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Development of Risk Prediction Equations for Incident Chronic Kidney Disease

Nelson, Robert G.; Grams, Morgan E.; Ballew, Shoshana H.; Sang, Yingying et al.

Part of Journal of the American Medical Association (JAMA), p. 2104-2114, 2019

• DOI for Development of Risk Prediction Equations for Incident Chronic Kidney Disease

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Kunkle, Brian W.; Giedraitis, Vilmantas; Kilander, Lena; Brundin, RoseMarie et al.

Part of Nature Genetics, p. 414-430, 2019

• DOI for Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Mosaic loss of chromosome Y in leukocytes matters

Forsberg, Lars A.; Halvardson, Jonatan; Rychlicka-Buniowska, Edyta; Danielsson, Marcus et al.

Part of Nature Genetics, p. 4-7, 2019

• DOI for Mosaic loss of chromosome Y in leukocytes matters

Longitudinal cognitive decline in autosomal-dominant Alzheimer's disease varies with mutations in APP and PSEN1 genes

Almkvist, Ove; Rodriguez-Vieitez, Elena; Thordardottir, Steinunn; Nordberg, Agneta et al.

Part of Neurobiology of Aging, p. 40-47, 2019

• DOI for Longitudinal cognitive decline in autosomal-dominant Alzheimer's disease varies with mutations in APP and PSEN1 genes

A beta and tau prion-like activities decline with longevity in the Alzheimer's disease human brain

Aoyagi, Atsushi; Condello, Carlo; Stöhr, Jan; Yue, Weizhou et al.

Part of Science Translational Medicine, 2019

• DOI for A beta and tau prion-like activities decline with longevity in the Alzheimer's disease human brain

Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers

Emami Khoonsari, Payam; Shevchenko, Ganna; Herman, Stephanie; Remnestal, Julia et al.

Part of Journal of Alzheimer's Disease, p. 639-651, 2019

• DOI for Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers
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Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

Pulit, Sara L.; Gustafsson, Stefan; Lind, Lars; Lannfelt, Lars et al.

Part of Neurology Genetics, 2018

• DOI for Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
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CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease

Gyorgy, Bence; Loov, Camilla; Zaborowski, Mikolaj P.; Takeda, Shuko et al.

Part of Molecular Therapy Nucleic Acids, p. 429-440, 2018

• DOI for CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease
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The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death

Söllvander, Sofia; Nikitidou, Elisabeth; Gallasch, Linn; Zysk, Marlena et al.

Part of Journal of Neuroinflammation, 2018

• DOI for The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death
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An Action Plan to Face the Challenge of Dementia: INTERNATIONAL STATEMENT ON DEMENTIA from IAP for Health

Chertkow, H.; Hogan, David B.; Black, Sandra; Feldman, Howard et al.

Part of The Journal of Prevention of Alzheimer's Disease, p. 207-212, 2018

• DOI for An Action Plan to Face the Challenge of Dementia: INTERNATIONAL STATEMENT ON DEMENTIA from IAP for Health

Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Meier, Silvio R.; Syvänen, Stina; Hultqvist, Greta; Fang, Xiaotian T. et al.

Part of Journal of Nuclear Medicine, p. 1885-1891, 2018

• DOI for Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
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Rapid amyloid-β oligomer and protofibril accumulation in traumatic brain injury

Abu Hamdeh, Sami; Rollman Waara, Erik; Möller, Christer; Söderberg, Linda et al.

Part of Brain Pathology, p. 451-462, 2018

• DOI for Rapid amyloid-β oligomer and protofibril accumulation in traumatic brain injury

Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Syvänen, Stina; Hultqvist, Greta; Gustavsson, Tobias; Gumucio, Astrid et al.

Part of Alzheimer's Research & Therapy, 2018

• DOI for Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
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[F-18]Tetrazine-trans-cyclooctene mediated labelling of antibodies for PET imaging of amyloid-beta

Eriksson, Jonas; Fang, Xiaotian T.; Hultqvist, Greta; Olberg, D. E. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Sinha, Maitrayee Sardar; Ansell-Schultz, Anna; Civitelli, Livia; Hildesjo, Camilla et al.

Part of Acta Neuropathologica, p. 41-56, 2018

• DOI for Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
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Structural heterogeneity and intersubject variability of A beta in familial and sporadic Alzheimer's disease

Condello, Carlo; Lemmin, Thomas; Stöhr, Jan; Nick, Mimi et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2018

• DOI for Structural heterogeneity and intersubject variability of A beta in familial and sporadic Alzheimer's disease
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Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

Fang, Xiaotian T.; Sehlin, Dag; Lannfelt, Lars; Syvänen, Stina et al.

Part of Biological Procedures Online, 2017

• DOI for Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
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Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data.

Matsushita, Kunihiro; Ballew, Shoshana H; Coresh, Josef; Arima, Hisatomi et al.

Part of The Lancet Diabetes and Endocrinology, p. 718-728, 2017

• DOI for Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data.

Efficient clearance of Amyloid-beta protofibrils in APP-transgenic mice treated with a brain penetrating bifunctional antibody

Sehlin, Dag; Hultqvist, Greta; Gumucio, Astrid; Laudon, H. et al.

Part of Journal of Cerebral Blood Flow and Metabolism, p. 415-416, 2017

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Strawbridge, Rona J.; Silveira, Angela; den Hoed, Marcel; Gustafsson, Stefan et al.

Part of Atherosclerosis, p. 196-204, 2017

• DOI for Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
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Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M. et al.

Part of Scientific Data, 2017

• DOI for Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
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Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Christophersen, Ingrid E.; Rienstra, Michiel; Roselli, Carolina; Yin, Xiaoyan et al.

Part of Nature Genetics, p. 946-+, 2017

• DOI for Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sims, Rebecca; van der Lee, Sven J.; Naj, Adam C.; Bellenguez, Celine et al.

Part of Nature Genetics, p. 1373-+, 2017

• DOI for Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Gustafsson, Gabriel; Lindström, Veronica; Rostami, Jinar; Nordström, Eva et al.

Part of Journal of Neuroinflammation, 2017

• DOI for Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
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Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease

Velickaite, Vilma; Giedraitis, Vilmantas; Ström, K; Alafuzoff, Irina et al.

Part of BMC Geriatrics, 2017

• DOI for Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease
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Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars et al.

Part of Theranostics, p. 308-318, 2017

• DOI for Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
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Decreased HHV-6 IgG in Alzheimer's Disease

Westman, Gabriel; Blomberg, Jonas; Yun, Zhibing; Lannfelt, Lars et al.

Part of Frontiers in Neurology, 2017

• DOI for Decreased HHV-6 IgG in Alzheimer's Disease

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Scott, Robert A.; Scott, Laura J.; Maegi, Reedik; Marullo, Letizia et al.

Part of Diabetes, p. 2888-2902, 2017

• DOI for An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein

Almandoz-Gil, Leire; Lindström, Veronica; Sigvardson, Jessica; Kahle, Philipp J. et al.

Part of Cellular and molecular neurobiology, p. 1217-1226, 2017

• DOI for Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein
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Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Part of Neuropharmacology, p. 293-300, 2017

• DOI for Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Cellular Uptake of alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of alpha-Synuclein and Mediated via Fc gamma Receptors

Gustafsson, Gabriel; Eriksson, Fredrik; Möller, Christer; da Fonseca, Tomas Lopes et al.

Part of Cellular and molecular neurobiology, p. 121-131, 2017

• DOI for Cellular Uptake of alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of alpha-Synuclein and Mediated via Fc gamma Receptors

The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta induced apoptosis

Nikitidou, Elisabeth; Söllvander, Sofia; Zyśk, Marlena; Söderberg, L. et al.

Part of Glia, 2017

• DOI for The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta induced apoptosis

Antibody-based PET radioligands for imaging of amyloid-beta protofibrils

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Falting, J. et al.

Part of Journal of Cerebral Blood Flow and Metabolism, p. 84-84, 2017

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling et al.

Part of Diabetes, p. 2019-2032, 2017

• DOI for A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Predicting Cognitive Decline across Four Decades in Mutation Carriers and Non-carriers in Autosomal-Dominant Alzheimer's Disease

Almkvist, Ove; Rodriguez-Vieitez, Elena; Thordardottir, Steinunn; Amberla, Kaarina et al.

Part of Journal of the International Neuropsychological Society, p. 195-203, 2017

• DOI for Predicting Cognitive Decline across Four Decades in Mutation Carriers and Non-carriers in Autosomal-Dominant Alzheimer's Disease

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R. et al.

Part of NeuroImage, p. 55-63, 2017

• DOI for A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
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Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

Dumanski, Jan P.; Lambert, Jean-Charles; Rasi, Chiara; Giedraitis, Vilmantas et al.

Part of American Journal of Human Genetics, p. 1208-1219, 2016

• DOI for Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
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mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts

Caruso, Vanni; Sreedharan, Smitha; Carlini, Valeria P.; Jacobsson, Josefin A. et al.

Part of Gene, p. 139-145, 2016

• DOI for mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen et al.

Part of Nature Genetics, p. 1151-1161, 2016

• DOI for Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Sehlin, Dag; Fang, Xiaotian T.; Cato, Linda; Antoni, Gunnar et al.

Part of Nature Communications, 2016

• DOI for Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
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Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, Sofia; Nikitidou, Elisabeth; Brolin, Robin; Soderberg, Linda et al.

Part of Molecular Neurodegeneration, 2016

• DOI for Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
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Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, Sofia; Nikitidou, Elisabeth; Brolin, Robin; Söderberg, Linda et al.

Part of Molecular Neurodegeneration, 2016

The genetic architecture of type 2 diabetes

Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M.; Mahajan, Anubha et al.

Part of Nature, p. 41-47, 2016

• DOI for The genetic architecture of type 2 diabetes

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease

Emami Khoonsari, Payam; Haggmark, Anna; Lönnberg, Maria; Mikus, Maria et al.

Part of PLOS ONE, 2016

• DOI for Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease
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High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease

Gunnarsson, Malin Degerman; Ingelsson, Martin; Blennow, Kaj; Basun, Hans et al.

Part of Alzheimer's Research & Therapy, 2016

• DOI for High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease
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Safety and tolerability of BAN2401 - a clinical study in Alzheimer's disease with a protofibril selective A beta antibody

Logovinsky, Veronika; Satlin, Andrew; Lai, Robert; Swanson, Chad et al.

Part of Alzheimer's Research & Therapy, 2016

• DOI for Safety and tolerability of BAN2401 - a clinical study in Alzheimer's disease with a protofibril selective A beta antibody
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Increased levels of extracellular microvesicle markers and decreased levels of endocytic/exocytic proteins in the Alzheimer’s disease brain

Sravani, Musunuri; Emami Khoonsari, Payam; Mikus, Maria; Wetterhall, Magnus et al.

Part of Journal of Alzheimer's Disease, p. 1671-1686, 2016

• DOI for Increased levels of extracellular microvesicle markers and decreased levels of endocytic/exocytic proteins in the Alzheimer’s disease brain

CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease

Remnestål, Julia; Just, David; Mitsios, Nicholas; Fredolini, Claudia et al.

Part of PROTEOMICS - Clinical Applications, p. 1242-1253, 2016

• DOI for CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease
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Deposition of C-terminally truncated A beta species A beta 37 and A beta 39 in Alzheimer's disease and transgenic mouse models

Reinert, Jochim; Richard, Bernhard C.; Klafki, Hans W.; Friedrich, Beate et al.

Part of Acta neuropathologica communications, 2016

• DOI for Deposition of C-terminally truncated A beta species A beta 37 and A beta 39 in Alzheimer's disease and transgenic mouse models
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Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

Hosp, Fabian; Vossfeldt, Hannes; Heinig, Matthias; Vasiljevic, Djordje et al.

Part of Cell Reports, p. 1134-1146, 2015

• DOI for Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins
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Mutagenesis: smoking is associated with mosaic loss of chromosome Y

Dumanski, Jan P.; Rasi, Chiara; Lönn, Mikael; Davies, Hanna et al.

Part of Science, p. 81-83, 2015

• DOI for Mutagenesis: smoking is associated with mosaic loss of chromosome Y

A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury.

James, Matthew T; Grams, Morgan E; Woodward, Mark; Elley, C Raina et al.

Part of American Journal of Kidney Diseases, p. 602-612, 2015

• DOI for A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury.

A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury

Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H; Gansevoort, Ron T et al.

Part of American Journal of Kidney Diseases, p. 591-601, 2015

• DOI for A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury

Changes in secondary structure of α-synuclein during oligomerization induced by reactive aldehydes.

Cai, Yixiao; Lendel, Christofer; Österlund, Lars; Kasrayan, Alex et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 336-341, 2015

• DOI for Changes in secondary structure of α-synuclein during oligomerization induced by reactive aldehydes.

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

Nikpay, Majid; Goel, Anuj; Won, Hong-Hee; Hall, Leanne M. et al.

Part of Nature Genetics, p. 1121-1130, 2015

• DOI for A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus

Chase, A.; Leung, W.; Tapper, W.; Jones, A. V. et al.

Part of Leukemia, p. 2069-2074, 2015

• DOI for Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus

Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

Mahajan, Anubha; Sim, Xueling; Ng, Hui Jin; Manning, Alisa et al.

Part of PLOS Genetics, 2015

• DOI for Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, Thomas W.; Justice, Anne E.; Graff, Mariaelisa; Barata, Llilda et al.

Part of PLOS Genetics, 2015

• DOI for The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
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Self-reported sleep disturbance is associated with Alzheimer's disease risk in men

Benedict, Christian; Byberg, Liisa; Cedernaes, Jonathan; Hogenkamp, Pleunie S et al.

Part of Alzheimer's & Dementia, p. 1090-1097, 2015

• DOI for Self-reported sleep disturbance is associated with Alzheimer's disease risk in men
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Convergent genetic and expression data implicate immunity in Alzheimer's disease

Jones, Lesley; Lambert, Jean-Charles; Wang, Li-San; Choi, Seung-Hoan et al.

Part of Alzheimer's & Dementia, p. 658-671, 2015

• DOI for Convergent genetic and expression data implicate immunity in Alzheimer's disease

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

Kvartsberg, Hlin; Duits, Flora H.; Ingelsson, Martin; Andreasen, Niels et al.

Part of Alzheimer's & Dementia, p. 1180-1190, 2015

• DOI for Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status

Sood, Sanjana; Gallagher, Iain J.; Lunnon, Katie; Rullman, Eric et al.

Part of Genome Biology, 2015

• DOI for A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
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Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease

Söllvander, Sofia; Ekholm-Pettersson, Frida; Brundin, Rose-Marie; Westman, Gabriel et al.

Part of Journal of Alzheimer's Disease, p. 63-72, 2015

• DOI for Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease
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Micellar extraction possesses a new advantage for the analysis of Alzheimer's disease brain proteome

Musunuri, Sravani; Kultima, Kim; Richard, Bernhard Clemens; Ingelsson, Martin et al.

Part of Analytical and Bioanalytical Chemistry, p. 1041-1057, 2015

• DOI for Micellar extraction possesses a new advantage for the analysis of Alzheimer's disease brain proteome

The Murine Version of BAN2401 (mAb158) Selectively Reduces Amyloid-beta Protofibrils in Brain and Cerebrospinal Fluid of tg-ArcSwe Mice

Tucker, Stina; Moller, Christer; Tegerstedt, Karin; Lord, Anna et al.

Part of Journal of Alzheimer's Disease, p. 575-588, 2015

• DOI for The Murine Version of BAN2401 (mAb158) Selectively Reduces Amyloid-beta Protofibrils in Brain and Cerebrospinal Fluid of tg-ArcSwe Mice

eta-Secretase processing of APP inhibits neuronal activity in the hippocampus

Willem, Michael; Tahirovic, Sabina; Busche, Marc Aurel; Ovsepian, Saak V. et al.

Part of Nature, p. 443-447, 2015

• DOI for eta-Secretase processing of APP inhibits neuronal activity in the hippocampus

Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

O'Callaghan, Paul; Li, Jin-Ping; Lannfelt, Lars; Lindahl, Ulf et al.

Part of Journal of Biological Chemistry, p. 14904-14914, 2015

• DOI for Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

O'Callaghan, Paul; Noborn, Fredrik; Sehlin, Dag; Li, Jin-ping et al.

Part of Amyloid, p. 76-87, 2014

• DOI for Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Forsberg, Lars A.; Rasi, Chiara; Malmqvist, Niklas; Davies, Hanna et al.

Part of Nature Genetics, p. 624-628, 2014

• DOI for Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease

Westman, Gabriel; Berglund, David; Widen, Johan; Ingelsson, Martin et al.

Part of PLOS ONE, 2014

• DOI for Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease
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Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men

Benedict, Christian; Cedernaes, Jonathan; Giedraitis, Vilmantas; Nilsson, Emil K et al.

Part of Sleep, p. 195-198, 2014

• DOI for Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men

Abundance of A beta(5-x) x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease

Guzman, Erika Avendano; Bouter, Yvonne; Richard, Bernhard C.; Lannfelt, Lars et al.

Part of Molecular Neurodegeneration, p. 13, 2014

• DOI for Abundance of A beta(5-x) x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease
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Quantification of the Brain Proteome in Alzheimer's Disease Using Multiplexed Mass Spectrometry

Musunuri, Sravani; Wetterhall, Magnus; Ingelsson, Martin; Lannfelt, Lars et al.

Part of Journal of Proteome Research, p. 2056-2068, 2014

• DOI for Quantification of the Brain Proteome in Alzheimer's Disease Using Multiplexed Mass Spectrometry

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

Escott-Price, Valentina; Bellenguez, Celine; Wang, Li-San; Choi, Seung-Hoan et al.

Part of PLOS ONE, 2014

• DOI for Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
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9th Key symposium Introduction: Updating Alzheimer's disease diagnosis implications for prevention and treatment

Kivipelto, M.; Mangialasche, F.; Solomon, A.; Johansson, G. et al.

Part of Journal of Internal Medicine, p. 202-203, 2014

• DOI for 9th Key symposium Introduction: Updating Alzheimer's disease diagnosis implications for prevention and treatment

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

Lindström, Veronica; Fagerqvist, Therese; Eva, Nordström; Eriksson, Fredrik et al.

Part of Neurobiology of Disease, p. 134-143, 2014

• DOI for Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

High Tau Levels in Cerebrospinal Fluid Predict Rapid Decline and Increased Dementia Mortality in Alzheimer's Disease

Degerman Gunnarsson, Malin; Lannfelt, Lars; Ingelsson, Martin; Basun, Hans et al.

Part of Dementia and Geriatric Cognitive Disorders, p. 196-206, 2014

• DOI for High Tau Levels in Cerebrospinal Fluid Predict Rapid Decline and Increased Dementia Mortality in Alzheimer's Disease

Amyloid-beta-directed immunotherapy for Alzheimer's disease

Lannfelt, Lars; Relkin, N. R.; Siemers, E. R.

Part of Journal of Internal Medicine, p. 284-295, 2014

• DOI for Amyloid-beta-directed immunotherapy for Alzheimer's disease
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Serial propagation of distinct strains of A beta prions from Alzheimer's disease patients

Watts, Joel C.; Condello, Carlo; Stoehr, Jan; Oehler, Abby et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 10323-10328, 2014

• DOI for Serial propagation of distinct strains of A beta prions from Alzheimer's disease patients

The amyloid-beta degradation pattern in plasma A possible tool for clinical trials in Alzheimer's disease

Pannee, Josef; Tornqvist, Ulrika; Westerlund, Anni; Ingelsson, Martin et al.

Part of Neuroscience Letters, p. 7-12, 2014

• DOI for The amyloid-beta degradation pattern in plasma A possible tool for clinical trials in Alzheimer's disease

A beta(38) in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models

Reinert, Jochim; Martens, Henrik; Huettenrauch, Melanie; Kolbow, Tekla et al.

Part of Journal of Alzheimer's Disease, p. 871-881, 2014

• DOI for A beta(38) in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Holmes, Michael V.; Dale, Caroline E.; Zuccolo, Luisa; Silverwood, Richard J. et al.

Part of BMJ-BRIT MED J, 2014

• DOI for Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging

Gumucio, Astrid; Lannfelt, Lars; Nilsson, Lars N. G.

Part of BMC Neuroscience, p. 148, 2013

• DOI for Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging
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Re-evaluation of clinical dementia diagnoses with pittsburgh compound B positron emission tomography

Degerman Gunnarsson, Malin; Lindau, M; Santillo, A F; Wall, Anders et al.

Part of Dementia and Geriatric Cognitive Disorders Extra, p. 472-481, 2013

• DOI for Re-evaluation of clinical dementia diagnoses with pittsburgh compound B positron emission tomography

Microglial Markers are Elevated in the Prodromal Phase of Alzheimer's Disease and Vascular Dementia

Olsson, Bob; Hertze, Joakim; Lautner, Ronald; Zetterberg, Henrik et al.

Part of Journal of Alzheimer's Disease, p. 45-53, 2013

• DOI for Microglial Markers are Elevated in the Prodromal Phase of Alzheimer's Disease and Vascular Dementia

Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain

Magnusson, Kristina; Sehlin, Dag; Syvänen, Stina; Svedberg, Marie M. et al.

Part of Journal of Alzheimer's Disease, p. 29-40, 2013

• DOI for Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain

The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ

Kalimo, Hannu; Lalowski, Maciej; Bogdanovic, Nenad; Philipson, Ola et al.

Part of Acta neuropathologica communications, p. 60, 2013

• DOI for The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Lambert, Jean-Charles; Ibrahim-Verbaas, Carla A.; Harold, Denise; Naj, Adam C. et al.

Part of Nature Genetics, p. 1452-U206, 2013

• DOI for Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Decreased Proportion of Cytomegalovirus Specific CD8 T-Cells but No Signs of General Immunosenescence in Alzheimer's Disease

Westman, Gabriel; Lidehall, Anna-Karin; Magnusson, Peetra; Ingelsson, Martin et al.

Part of PLOS ONE, 2013

• DOI for Decreased Proportion of Cytomegalovirus Specific CD8 T-Cells but No Signs of General Immunosenescence in Alzheimer's Disease
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Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis

Rubio-Moscardo, Fanny; Seto-Salvia, Nuria; Pera, Marta; Bosch-Morato, Monica et al.

Part of PLOS ONE, 2013

• DOI for Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis
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Off-pathway alpha-synuclein oligomers seem to alter alpha-synuclein turnover in a cell model but lack seeding capability in vivo

Fagerqvist, Therese; Näsström, Thomas; Ihse, Elisabet; Lindström, Veronica et al.

Part of Amyloid, p. 233-244, 2013

• DOI for Off-pathway alpha-synuclein oligomers seem to alter alpha-synuclein turnover in a cell model but lack seeding capability in vivo

Cerebrospinal Fluid Levels of Heart Fatty Acid Binding Protein are Elevated Prodromally in Alzheimer's Disease and Vascular Dementia

Olsson, Bob; Hertze, Joakim; Ohlsson, Mattias; Nägga, Katarina et al.

Part of Journal of Alzheimer's Disease, p. 673-679, 2013

• DOI for Cerebrospinal Fluid Levels of Heart Fatty Acid Binding Protein are Elevated Prodromally in Alzheimer's Disease and Vascular Dementia

Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

Fagerqvist, Therese; Lindström, Veronica; Nordstrom, Eva; Lord, Anna et al.

Part of Journal of Neurochemistry, p. 131-144, 2013

• DOI for Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

Lambert, J-C; Grenier-Boley, B.; Harold, D.; Zelenika, D. et al.

Part of Molecular Psychiatry, p. 461-470, 2013

• DOI for Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

Prediction of Mild Cognitive Impairment that Evolves into Alzheimer's Disease Dementia within Two Years using a Gene Expression Signature in Blood: A Pilot Study

Roed, Line; Grave, Gisle; Lindahl, Torbjorn; Rian, Edith et al.

Part of Journal of Alzheimer's Disease, p. 611-621, 2013

• DOI for Prediction of Mild Cognitive Impairment that Evolves into Alzheimer's Disease Dementia within Two Years using a Gene Expression Signature in Blood: A Pilot Study
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N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

Antonios, Gregory; Saiepour, Nasrin; Bouter, Yvonne; Richard, Bernhard C et al.

Part of Acta neuropathologica communications, p. 56, 2013

• DOI for N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate

Matsushita, Kunihiro; Mahmoodi, Bakhtawar K; Woodward, Mark; Emberson, Jonathan R et al.

Part of Journal of the American Medical Association (JAMA), p. 1941-1951, 2012

• DOI for Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate

Age-related accumulation of somatic structural changes in the nuclear genome of human blood cells in vivo

Dumanski, Jan P.; Forsberg, L. A.; Rasi, C.; Razzaghian, H. R. et al.

Part of Journal of Medical Genetics, 2012

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain

Zhang, Xiao; Wang, Bo; O'Callaghan, Paul; Hjertstrom, Elina et al.

Part of Acta Neuropathologica, p. 465-478, 2012

• DOI for Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain

The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ

Philipson, Ola; Lord, Anna; Lalowski, Maciej; Soliymani, Rabah et al.

Part of Neurobiology of Aging, p. 10100-10100000000000000, 2012

• DOI for The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ

Large Aggregates Are the Major Soluble Ab Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Sehlin, Dag; Englund, Hillevi; Simu, Barbro; Karlsson, Mikael et al.

Part of PLOS ONE, 2012

• DOI for Large Aggregates Are the Major Soluble Ab Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Serum fatty-acid composition and the risk of Alzheimer’s disease: a longitudinal population based study

Rönnemaa, Elina; Zethelius, Björn; Vessby, Bengt; Lannfelt, Lars et al.

Part of European Journal of Clinical Nutrition, p. 885-890, 2012

• DOI for Serum fatty-acid composition and the risk of Alzheimer’s disease: a longitudinal population based study

Age-related somatic structural changes in the nuclear genome of human blood cells

Forsberg, Lars A.; Rasi, Chiara; Razzaghian, Hamid R; Pakalapati, Geeta et al.

Part of American Journal of Human Genetics, p. 217-228, 2012

• DOI for Age-related somatic structural changes in the nuclear genome of human blood cells

Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children

Jacobsson, Josefin; Rask-Andersen, Mathias; Risérus, Ulf; Moschonis, G et al.

Part of International Journal of Obesity, p. 119-129, 2012

• DOI for Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Diogenes, Maria Jose; Dias, Raquel B.; Rombo, Diogo M.; Miranda, Hugo Vicente et al.

Part of Journal of Neuroscience, p. 11750-11762, 2012

• DOI for Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Extreme Stability of Chitotriosidase in Cerebrospinal Fluid makes it a Suitable Marker for Microglial Activation in Clinical Trials

Olsson, Bob; Malmestrom, Clas; Basun, Hans; Annas, Peter et al.

Part of Journal of Alzheimer's Disease, p. 273-276, 2012

• DOI for Extreme Stability of Chitotriosidase in Cerebrospinal Fluid makes it a Suitable Marker for Microglial Activation in Clinical Trials

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Manning, Alisa K.; Hivert, Marie-France; Scott, Robert A.; Grimsby, Jonna L. et al.

Part of Nature Genetics, p. 659-669, 2012

• DOI for A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Immunotherapy in Alzheimer's disease - targeting toxic A beta protofibrils

Lannfelt, Lars

Part of European Neuropsychopharmacology, 2012

• DOI for Immunotherapy in Alzheimer's disease - targeting toxic A beta protofibrils

Longitudinal Stability Evaluation of Biomarkers and Their Correlation in Cerebrospinal Fluid and Plasma from Patients with Alzheimer's Disease

Höglund, Kina; Bogstedt, Anna; Fabre, Susanne; Aziz, Ali et al.

Part of Journal of Alzheimer's Disease, p. 939-947, 2012

• DOI for Longitudinal Stability Evaluation of Biomarkers and Their Correlation in Cerebrospinal Fluid and Plasma from Patients with Alzheimer's Disease

The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men

Benedict, Christian; Jacobsson, Josefin A; Rönnemaa, Elina; Sällman Almén, Markus et al.

Part of Neurobiology of Aging, p. 11590-115900000, 2011

• DOI for The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men

Antibodies against alpha-synuclein reduce oligomerization in living cells

Näsström, Thomas; Goncalves, Susana; Sahlin, Charlotte; Nordström, Eva et al.

Part of PLOS ONE, 2011

• DOI for Antibodies against alpha-synuclein reduce oligomerization in living cells
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Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-A beta Antibodies

Sehlin, Dag; Hedlund, Marie; Lord, Anna; Englund, Hillevi et al.

Part of Neurodegenerative Diseases, p. 117-123, 2011

• DOI for Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-A beta Antibodies

Novel Progranulin Mutation Detected in 2 Patients With FTLD

Skoglund, Lena; Matsui, Toshifumi; Freeman, Stefanie H.; Wallin, Anders et al.

Part of Alzheimer Disease and Associated Disorders, p. 173-178, 2011

• DOI for Novel Progranulin Mutation Detected in 2 Patients With FTLD

Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Abeta in plasma of patients with Alzheimer's disease

Marcello, Andrea; Wirths, Oliver; Schneider-Axmann, Thomas; Degerman-Gunnarsson, Malin et al.

Part of Neurobiology of Aging, p. 1379-1387, 2011

• DOI for Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Abeta in plasma of patients with Alzheimer's disease

In vivo imaging of astrocytosis in Alzheimer's disease: an ¹¹C-L-deuteriodeprenyl and PIB PET study

Santillo, Alexander Frizell; Gambini, Juan Pablo; Lannfelt, Lars; Långström, Bengt et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 2202-2208, 2011

• DOI for In vivo imaging of astrocytosis in Alzheimer's disease: an ¹¹C-L-deuteriodeprenyl and PIB PET study

Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease

Yang, Jing; Lunde, Lisa K; Nuntagij, Paworn; Oguchi, Tomohiro et al.

Part of Journal of Alzheimer's Disease, p. 711-722, 2011

• DOI for Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease

Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation

Schöll, Michael; Almkvist, Ove; Axelman, Karin; Stefanova, Elka et al.

Part of Neurobiology of Aging, p. 1388-1399, 2011

• DOI for Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

Näsström, Thomas; Fagerqvist, Therese; Barbu, Mikael; Karlsson, Mikael et al.

Part of Free Radical Biology & Medicine, p. 428-437, 2011

• DOI for The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

Gelsolin co-occurs with Lewy bodies in vivo and accelerates alpha-synuclein aggregation in vitro

Welander, Hedvig; Bontha, Sai Vineela; Näsström, Tomas; Karlsson, Mikael et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 32-38, 2011

• DOI for Gelsolin co-occurs with Lewy bodies in vivo and accelerates alpha-synuclein aggregation in vitro

Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort

Rönnemaa, Elina; Zethelius, Björn; Lannfelt, Lars; Kilander, Lena

Part of Dementia and Geriatric Cognitive Disorders, p. 460-466, 2011

• DOI for Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort

Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease

Kamali-Moghaddam, Masood; Ekholm Pettersson, Frida; Wu, Di; Englund, Hillevi et al.

Part of BMC Neuroscience, p. 124, 2010

• DOI for Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid

Giedraitis, Vilmantas; Glaser, Anna; Sarajärvi, Timo; Brundin, RoseMarie et al.

Part of Neuroscience Letters, p. 265-267, 2010

• DOI for CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid

Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs

Sehlin, Dag; Söllvander, Sofia; Paulie, Staffan; Brundin, RoseMarie et al.

Part of Journal of Alzheimer's Disease, p. 1295-1301, 2010

• DOI for Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs

Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

Sundelöf, Johan; Sundström, Johan; Hansson, Oskar; Eriksdotter-Jönhagen, Maria et al.

Part of Journal of Alzheimer's Disease, p. 1223-1230, 2010

• DOI for Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

Blom, Elin S; Wang, Yijing; Skoglund, Lena; Hansson, Anita C et al.

Part of International journal of Alzheimer's disease, p. 936580, 2010

• DOI for Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

Sandberg, Anders; Luheshi, Leila M.; Söllvander, Sofia; Pereira de Barros, Teresa et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 15595-15600, 2010

• DOI for Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

Identification of low molecular weight pyroglutamate Aβ oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

Wirths, Oliver; Erck, Christian; Martens, Henrik; Harmeier, Anja et al.

Part of Journal of Biological Chemistry, p. 41517-41524, 2010

• DOI for Identification of low molecular weight pyroglutamate Aβ oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study

Degerman Gunnarsson, Malin; Lindau, Maria; Wall, Anders; Blennow, K et al.

Part of Dementia and Geriatric Cognitive Disorders, p. 204-212, 2010

• DOI for Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

Faux, Noel G; Ritchie, Craig W; Gunn, Adam; Rembach, Alan et al.

Part of Journal of Alzheimer's Disease, p. 509-516, 2010

• DOI for PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

Sandwall, Elina; O'Callaghan, Paul; Zhang, Xiao; Lindahl, Ulf et al.

Part of Glycobiology, p. 533-541, 2010

• DOI for Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

Neurofilament ELISA validation

Petzold, Axel; Altintas, Ayse; Andreoni, Laura; Bartos, Ales et al.

Part of JIM - Journal of Immunological Methods, p. 23-31, 2010

• DOI for Neurofilament ELISA validation

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

Wirths, Oliver; Bethge, Tobias; Marcello, Andrea; Harmeier, Anja et al.

Part of Journal of neural transmission, p. 85-96, 2010

• DOI for Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Wiig, E H; Annas, P; Basun, H; Andreasen, N et al.

Part of Acta Neurologica Scandinavica, p. 186-193, 2010

• DOI for The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders

Israelsson, Charlotte; Bengtsson, Henrik; Lobell, Anna; Nilsson, Lars N. G. et al.

Part of European Journal of Neuroscience, p. 852-863, 2010

• DOI for Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders

Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Wesnes, K; Edgar, C.; Andreasen, N.; Annas, P. et al.

Part of Acta Neurologica Scandinavica, p. 270-277, 2010

• DOI for Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Cystatin C Levels are Positively Correlated with both Aβ₄₂ and Tau Levels in Cerebrospinal Fluid in Persons with Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls

Sundelöf, Johan; Sundstrom, Johan; Hansson, Oskar; Eriksdotter-Jönhagen, Maria et al.

Part of Journal of Alzheimer's Disease, p. 471-478, 2010

• DOI for Cystatin C Levels are Positively Correlated with both Aβ₄₂ and Tau Levels in Cerebrospinal Fluid in Persons with Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls

Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study

Codita, Alina; Gumucio, Astrid; Lannfelt, Lars; Gellerfors, Pär et al.

Part of Behavioural Brain Research, p. 83-94, 2010

• DOI for Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study

The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study

Lambert, Jean-Charles; Sleegers, Kristel; Gonzalez-Perez, Antonio; Ingelsson, Martin et al.

Part of Journal of Alzheimer's Disease, p. 247-255, 2010

• DOI for The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study

Separation and characterization of aggregated species of amyloid-beta peptides

Wiberg, Henning; Ek, Patrik; Ekholm Pettersson, Frida; Lannfelt, Lars et al.

Part of Analytical and Bioanalytical Chemistry, p. 2357-2366, 2010

• DOI for Separation and characterization of aggregated species of amyloid-beta peptides

Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice

Marklund, Niklas; Morales, D; Clausen, Fredrik; Hånell, Anders et al.

Part of Neuroscience, p. 540-551, 2009

• DOI for Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice

The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924

Jacobsson, Josefin A; Risérus, Ulf; Axelsson, Tomas; Lannfelt, Lars et al.

Part of BMC Medical Genetics, p. 131, 2009

• DOI for The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924

Further analysis of previously implicated linkage regions for Alzheimer’s disease in affected relative pairs

Blom, Elin Susanne; Giedraitis, Vilmantas; Arepalli, Sampath; Hamshere, Marian L. et al.

Part of BMC Medical Genetics, p. 122, 2009

• DOI for Further analysis of previously implicated linkage regions for Alzheimer’s disease in affected relative pairs

Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men

Giedraitis, Vilmantas; Kilander, Lena; Degerman-Gunnarsson, Malin; Sundelöf, Johan et al.

Part of Dementia and Geriatric Cognitive Disorders, p. 59-68, 2009

• DOI for Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men

Circulating immune complexes of A beta and IgM in plasma of patients with Alzheimer's disease

Marcello, Andrea; Wirths, Oliver; Schneider-Axmann, Thomas; Degerman-Gunnarsson, Malin et al.

Part of Journal of neural transmission, p. 913-920, 2009

• DOI for Circulating immune complexes of A beta and IgM in plasma of patients with Alzheimer's disease

Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice

Lord, Anna; Englund, Hillevi; Söderberg, Linda; Tucker, Stina et al.

Part of The FEBS Journal, p. 995-1006, 2009

• DOI for Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice

Oligomerization partially explains the lowering of Aβ42 in Alzheimer's disease cerebrospinal fluid

Englund, Hillevi; Degerman Gunnarsson, Malin; Brundin, RoseMarie; Hedlund, Marie et al.

Part of Neuro-degenerative diseases, p. 139-147, 2009

• DOI for Oligomerization partially explains the lowering of Aβ42 in Alzheimer's disease cerebrospinal fluid

A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice

Philipson, Ola; Hammarström, Per; Nilsson, K Peter R; Portelius, Erik et al.

Part of Neurobiology of Aging, p. 1393-1405, 2009

• DOI for A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice

Glucose metabolism and the risk of Alzheimer's disease and dementia: a population-based 12 year follow-up study in 71-year-old men

Rönnemaa, Elina; Zethelius, Björn; Sundelöf, Johan; Sundström, Johan et al.

Part of Diabetologia, p. 1504-1510, 2009

• DOI for Glucose metabolism and the risk of Alzheimer's disease and dementia: a population-based 12 year follow-up study in 71-year-old men

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

Lord, Anna; Gumucio, Astrid; Englund, Hillevi; Sehlin, Dag et al.

Part of Neurobiology of Disease, p. 425-434, 2009

• DOI for An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

Sällsynta mutationer leder till framtidens behandling

Ingelsson, Martin; Basun, Hans; Pettersson, Frida Ekholm; Kilander, Lena et al.

Part of Läkartidningen, p. 1396-1400, 2009

Systemic inflammation and the risk of Alzheimer's disease and dementia: a prospective population-based study

Sundelöf, Johan; Kilander, Lena; Helmersson, Johanna; Larsson, Anders et al.

Part of Journal of Alzheimer's Disease, p. 79-87, 2009

• DOI for Systemic inflammation and the risk of Alzheimer's disease and dementia: a prospective population-based study

Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study

Sundelöf, Johan; Kilander, Lena; Helmersson, Johanna; Larsson, Anders et al.

Part of Journal of Alzheimer's Disease, p. 71-78, 2009

• DOI for Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study

Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice

Philipson, Ola; Lannfelt, Lars; Nilsson, Lars N. G.

Part of FEBS Letters, p. 3021-3026, 2009

• DOI for Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice

No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration

Skoglund, Lena; Ingvast, Sofie; Matsui, Toshifumi; Freeman, Stefanie et al.

Part of Dementia and Geriatric Cognitive Disorders, p. 471-475, 2009

• DOI for No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration

Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation

Skoglund, Lena; Brundin, RoseMarie; Olofsson, Tommie; Kalimo, Hannu et al.

Part of Neurogenetics, p. 27-34, 2009

• DOI for Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation

Frontotemporal Dementia-amyotrophic Lateral Sclerosis Complex is Simulated by Neurodegeneration With Brain Iron Accumulation

Santillo, Alexander; Skoglund, Lena; Lindau, Maria; Eeg-Olofsson, Karin et al.

Part of Alzheimer Disease and Associated Disorders, p. 298-300, 2009

• DOI for Frontotemporal Dementia-amyotrophic Lateral Sclerosis Complex is Simulated by Neurodegeneration With Brain Iron Accumulation

A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease

Verwey, N. A.; van der Flier, W M; Blennow, K; Clark, C et al.

Part of Annals of Clinical Biochemistry, p. 235-240, 2009

• DOI for A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease

Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype

Blom, Elin S.; Giedraitis, Vilmantas; Zetterberg, Henrik; Fukumoto, Hiroaki et al.

Part of Dementia and Geriatric Cognitive Disorders, p. 458-464, 2009

• DOI for Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype

The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers

Näsström, Thomas; Wahlberg, Therese; Karlsson, Mikael; Nikolajeff, Fredrik et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 872-876, 2009

• DOI for The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers

Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

O'Callaghan, Paul; Sandwall, Elina; Li, Jin-Ping; Yu, Hong et al.

Part of Brain Pathology, p. 548-561, 2008

• DOI for Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

Plasma β Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men: A Prospective, Population-Based Cohort Study

Sundelöf, Johan; Giedraitis, Vilmantas; Irizarry, Michael C; Sundström, Johan et al.

Part of Archives of Neurology, p. 256-63, 2008

• DOI for Plasma β Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men: A Prospective, Population-Based Cohort Study

Safety, efficacy, and biomarker findings of PBT2 in targeting A beta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

Lannfelt, Lars; Blennow, Kaj; Zetterberg, Henrik; Batsman, Stellan et al.

Part of Lancet Neurology, p. 779-786, 2008

• DOI for Safety, efficacy, and biomarker findings of PBT2 in targeting A beta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

The tau S305S mutation causes frontotemporal dementia with parkinsonism

Skoglund, Lena; Viitanen, Matti; Kalimo, Hannu; Lannfelt, Lars et al.

Part of European Journal of Neurology, p. 156-161, 2008

• DOI for The tau S305S mutation causes frontotemporal dementia with parkinsonism

Does APOE explain the linkage of Alzheimer’s disease to chromosome 19q13?

Blom, Elin Susanne; Holmans, Peter; Arepalli, Sampath; Adighibe, Omanma et al.

Part of American Journal of Medical Genetics Part B: Neuropsychiatric Genetics American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, p. 778-83, 2008

• DOI for Does APOE explain the linkage of Alzheimer’s disease to chromosome 19q13?

Low prevalence of APP duplications in Swedish and Finnish patients with early onset Alzheimer's disease

Blom, Elin Susanne; Viswanathan, Jayashree; Kilander, Lena; Helisalmi, Seppo et al.

Part of European Journal of Human Genetics, p. 171-5, 2008

• DOI for Low prevalence of APP duplications in Swedish and Finnish patients with early onset Alzheimer's disease

USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study

Auro, K.; Kristiansson, K.; Zethelius, Björn; Berne, Christian et al.

Part of Diabetologia, p. 464-472, 2008

• DOI for USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study

Serum cystatin C and the risk of Alzheimer disease in elderly men

Sundelöf, Johan; Ärnlöv, J.; Ingelsson, E.; Sundström, J. et al.

Part of Neurology, p. 1072-1079, 2008

• DOI for Serum cystatin C and the risk of Alzheimer disease in elderly men

No association between CALHM1 and Alzheimer's disease risk

Bertram, Lars; Schjeide, Brit-Maren M.; Hooli, Basavaraj; Mullin, Kristina et al.

Part of Cell, p. 993-994, 2008

• DOI for No association between CALHM1 and Alzheimer's disease risk

Impaired insulin secretion increases the risk of Alzheimer disease

Rönnemaa, E; Zethelius, B; Sundelöf, J; Sundström, J et al.

Part of Neurology, p. 1046-47, 2008

• DOI for Impaired insulin secretion increases the risk of Alzheimer disease

Clinical and Neuropathological Features of the Arctic APP Gene Mutation Causing Early-Onset Alzheimer Disease

Basun, Hans; Bogdanovic, Nenad; Ingelsson, Martin; Almkvist, Ove et al.

Part of Archives of Neurology, p. 499-505, 2008

• DOI for Clinical and Neuropathological Features of the Arctic APP Gene Mutation Causing Early-Onset Alzheimer Disease

In vivo amyloid imaging with PET in frontotemporal dementia

Engler, Henry; Santillo, Alexander Frizell; Wang, Shu Xia; Lindau, Maria et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 100-106, 2008

• DOI for In vivo amyloid imaging with PET in frontotemporal dementia

Docosahexaenoic acid stabilizes soluble amyloid-β protofibrils and sustains amyloid-β induced neurotoxicity in vitro

Johansson, Ann-Sofi; Garlind, Anita; Berglind-Dehlin, Fredrik; Karlsson, Göran et al.

Part of The FEBS Journal, p. 990-1000, 2007

• DOI for Docosahexaenoic acid stabilizes soluble amyloid-β protofibrils and sustains amyloid-β induced neurotoxicity in vitro

Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Aβ levels in cellular models of Alzheimer's disease

Sahlin, Charlotte; Ekholm Pettersson, Frida; Nilsson, Lars; Lannfelt, Lars et al.

Part of European Journal of Neuroscience, p. 882-889, 2007

• DOI for Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Aβ levels in cellular models of Alzheimer's disease

Attenuated amyloid-β aggregation and neurotoxicity owing to methionine oxidation

Johansson, Ann-Sofi; Bergquist, Jonas; Volbracht, Christiane; Päiviö, Anna et al.

Part of NeuroReport, p. 559-563, 2007

Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes

Nilsson, K. Peter R.; Åslund, Andreas; Berg, Ina; Nyström, Sofie et al.

Part of ACS Chemical Biology, p. 553-560, 2007

• DOI for Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes

Sensitive ELISA detection of amyloid-β protofibrils in biological samples

Englund, Hillevi; Sehlin, Dag; Johansson, Ann-Sofi; Nilsson, Lars N.G. et al.

Part of Journal of Neurochemistry, p. 334-345, 2007

• DOI for Sensitive ELISA detection of amyloid-β protofibrils in biological samples

Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity

Warensjö, Eva; Ingelsson, Erik; Lundmark, Per; Lannfelt, Lars et al.

Part of Obesity, p. 1732-1740, 2007

• DOI for Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity

Apolipoprotein E epsilon 4 genotype is independently associated with increased intima-media thickness in a recessive pattern

Wohlin, Martin; Sundström, Johan; Lannfelt, Lars; Axelsson, Tomas et al.

Part of Lipids, p. 451-456, 2007

• DOI for Apolipoprotein E epsilon 4 genotype is independently associated with increased intima-media thickness in a recessive pattern

The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease

Giedraitis, Vilmantas; Sundelöf, Johan; Irizarry, Michael C; Gårevik, Nina et al.

Part of Neuroscience Letters, p. 127-131, 2007

• DOI for The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease

Increase in beta-Amyloid Levels in Cerebrospinal Fluid of Children with Down Syndrome

Englund, Hillevi; Annerén, Göran; Gustafsson, Jan; Wester, Ulrika et al.

Part of Dementia and Geriatric Cognitive Disorders, p. 369-374, 2007

• DOI for Increase in beta-Amyloid Levels in Cerebrospinal Fluid of Children with Down Syndrome

Reduction of Phosphorylated Tau during Memantine Treatment of Alzheimer's Disease

Degerman Gunnarsson, Malin; Kilander, Lena; Basun, Hans; Lannfelt, Lars

Part of Dementia and Geriatric Cognitive Disorders, p. 247-252, 2007

• DOI for Reduction of Phosphorylated Tau during Memantine Treatment of Alzheimer's Disease

Longitudinal stability of CSF biomarkers in Alzheimer's disease

Blennow, Kaj; Zetterberg, Henrik; Minthon, Lennart; Lannfelt, Lars et al.

Part of Neuroscience Letters, p. 18-22, 2007

• DOI for Longitudinal stability of CSF biomarkers in Alzheimer's disease

Underskatta inte värdet av transgena djurmodeller av Alzheimers sjukdom

Nilsson, Lars; Lannfelt, Lars; Basun, Hans; Nordberg, Agneta et al.

Part of Läkartidningen, p. 798-800, 2007

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

Sahlin, Charlotte; Lord, Anna; Magnusson, Kristina; Englund, Hillevi et al.

Part of Journal of Neurochemistry, p. 854-862, 2007

• DOI for The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

Association study of cholesterol-related genes in Alzheimer's disease

Wollmer, M Axel.; Sleegers, Kristel; Ingelsson, Martin; Zekanowski, Cezary et al.

Part of Neurogenetics, p. 179-188, 2007

• DOI for Association study of cholesterol-related genes in Alzheimer's disease

New Alzheimer's disease locus on chromosome 8

Giedraitis, Vilmantas; Hedlund, M.; Skoglund, Lena; Blom, Elin et al.

Part of Journal of Medical Genetics, p. 931-935, 2006

• DOI for New Alzheimer's disease locus on chromosome 8

The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice.

Lord, Anna; Kalimo, Hannu; Eckman, Chris; Zhang, Xiao-Qun et al.

Part of Neurobiol Aging, p. 67-77, 2006

Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation.

Murphy, Eric J; Huang, Hsueh-Meei; Cowburn, Richard F; Lannfelt, Lars et al.

Part of Brain Res Bull, p. 79-85, 2006

Physiochemical characterization of the Alzheimer's disease-related peptides A beta 1-42Arctic and A beta 1-42wt

Johansson, Ann-Sofi; Berglind-Dehlin, Fredrik; Karlsson, Göran; Edwards, Katarina et al.

Part of FEBS Journal, p. 2618-30, 2006

• DOI for Physiochemical characterization of the Alzheimer's disease-related peptides A beta 1-42Arctic and A beta 1-42wt

Identification of novel biomarker candidates by differential peptidomics analysis of cerebrospinal fluid in Alzheimer's disease.

Selle, Hartmut; Lamerz, Jens; Buerger, Katharina; Dessauer, Andreas et al.

Part of Comb Chem High Throughput Screen, p. 801-6, 2005

Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia.

Wiltfang, J; Lewczuk, P; Riederer, P; Grunblatt, E et al.

Part of World J Biol Psychiatry, p. 69-84, 2005

Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.

Flood, F; Murphy, S; Cowburn, R F; Lannfelt, L et al.

Part of Biochem J, p. 545-50, 2005

Konformationsförändrade proteiner orsakar neurodegenerativa sjukdomar

Ingelsson, Martin; Nilsson, Lars; Basun, Hans; Aquilonius, Sten-Magnus et al.

Part of Läkartidningen, p. 3542-3551, 2005

Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay.

Stenh, Charlotte; Englund, Hillevi; Lord, Anna; Johansson, Ann-Sofi et al.

Part of Ann Neurol, p. 147-50, 2005

Unique physicochemical profile of beta-amyloid peptide variant Abeta1-40E22G protofibrils: conceivable neuropathogen in arctic mutant carriers.

Päiviö, A; Jarvet, J; Gräslund, A; Lannfelt, L et al.

Part of J Mol Biol, p. 145-59, 2004

Clinical and molecular aspects of frontotemporal dementia.

Froelich-Fabre, Susanne; Skoglund, Lena; Ostojic, Jovanka; Kilander, Lena et al.

Part of Neurodegener Dis, p. 218-24, 2004

No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found.

Johnson, J; Ostojic, J; Lannfelt, L; Glaser, A et al.

Part of Neurosci Lett, p. 99-101, 2004

The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy.

Ostojic, J; Elfgren, C; Passant, U; Nilsson, K et al.

Part of Dement Geriatr Cogn Disord, p. 298-301, 2004

Familial presenile dementia with bitemporal atrophy.

Passant, U; Ostojic, J; Froelich Fabre, S; Gustafson, L et al.

Part of Dement Geriatr Cogn Disord, p. 287-92, 2004

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid-β fibril formation

Pagnon de la Vega, María; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Part of Science Translational Medicine

A light at the end of the tunnel: from mutation identification to a potential treatment for Alzheimer’s disease

Lannfelt, Lars

Part of Upsala Journal of Medical Sciences, 2023

• DOI for A light at the end of the tunnel: from mutation identification to a potential treatment for Alzheimer’s disease
• Download full text (pdf) of A light at the end of the tunnel: from mutation identification to a potential treatment for Alzheimer’s disease

The Amyloid-beta Pathway in Alzheimer's Disease

Hampel, Harald; Hardy, John; Blennow, Kaj; Chen, Christopher et al.

Part of Molecular Psychiatry, p. 5481-5503, 2021

• DOI for The Amyloid-beta Pathway in Alzheimer's Disease
• Download full text (pdf) of The Amyloid-beta Pathway in Alzheimer's Disease

Immunotherapy targeting alpha-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders

Lindström, Veronica; Ihse, Elisabet; Fagerqvist, Therese; Bergström, Joakim et al.

Part of Immunotherapy, p. 141-153, 2014

• DOI for Immunotherapy targeting alpha-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders

Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease

Lannfelt, Lars; Moller, Christer; Basun, Hans; Osswald, Gunilla et al.

Part of ALZHEIMERS RES THER, p. 16, 2014

• DOI for Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease
• Download full text (pdf) of Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease

Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease

Lannfelt, Lars; Ekholm Pettersson, Frida; Nilsson, Lars N. G.

Part of Nutrition reviews, 2010

• DOI for Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease

Animal models of amyloid-β-related pathologies in Alzheimer’s disease

Philipson, Ola; Lord, Anna; Gumucio, Astrid; O'Callaghan, Paul et al.

Part of The FEBS Journal, p. 1389-1409, 2010

• DOI for Animal models of amyloid-β-related pathologies in Alzheimer’s disease

Consensus Paper of the WFSBP Task Force on Biological Markers of Dementia: The role of CSF and blood analysis in the early and differential diagnosis of dementia

Wiltfang, J.; Lewczuk, P.; Riederer, P.; Gruenblatt, E. et al.

Part of Revista de Psiquiatria Clinica, p. 1-16, 2009

Journal of Labelled Compounds and Pharmaceuticals: Neurosciences session

Rokka, Johanna; Fang, Xiaotian T.; Hultqvist, Greta; Faresjö, Rebecca et al.

Part of ISRS 2019, 2019

• DOI for Journal of Labelled Compounds and Pharmaceuticals: Neurosciences session

Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo

Wahlberg, Therese; Näsström, Thomas; Sahlin, Charlotte; Ingvast, Sofie et al.

2010

• DOI for Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo

Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo

Ingelsson, Martin; Wahlberg, Therese; Näsström, Thomas; Sahlin, Charlotte et al.

2010

Details of neuropathology in Arctic Alzheimer's disease

Kalimo, H.; Bogdanovic, N.; Callaghan, Paul O.; Bird, T. D. et al.

Part of Abstracts of the XVIIth International Congress of Neuropathology (ICN 2010), Salzburg, Austria, 11-15 September 2010, p. 22-23, 2010

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Morphological and functional differences of aldehyde-induced alpha-synuclein oligomers

Näsström, Thomas; Wahlberg, Therese; Barbu, Mikael; Silva, V. et al.

Part of Amyloid - Journal of Protein Folding Disorders, p. 93-94, 2010

Effects of lipid peroxidation metabolites on alpha-synuclein aggregation

Bergström, Joakim; Näsström, Thomas; Wahlberg, Therese; Karlsson, Mikael et al.

2009

GPR162 is expressed in the hypothalamus and is involved in food intake related behaviour

Sreedharan, Smitha; Carlini, Valeria P; Jacobsson, Josefin A; Olszewski, Pawel K et al.

2011

The Uppsala APP mutation promotes wildtype Aβ aggregation and deposition in vivo

Pagnon de la Vega, María; Ge, Junyue; Giedraitis, Vilmantas; Syvänen, Stina et al.

Transgenic mice harboring the Uppsala APP mutation display altered APP processing and accelerated Aβ42 pathology with distinct structural features

Pagnon de la Vega, María; Syvänen, Stina; Hooley, Monique; Giedraitis, Vilmantas et al.