Lars Lannfelt
Professor emeritus vid Institutionen för folkhälso- och vårdvetenskap; Molekylär geriatrik/ Rudbecklaboratoriet
- E-post:
- lars.lannfelt@uu.se
- Besöksadress:
- Dag Hammarskjölds väg 20
- Postadress:
- Rudbecklaboratoriet
751 85 Uppsala
- Akademiska meriter:
- överläk.
Publikationer
Senaste publikationer
Ingår i Molecular and Cellular Neuroscience, 2024
- DOI för Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
- Ladda ner fulltext (pdf) av Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
Ingår i Molecular and Cellular Neuroscience, 2024
- DOI för Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
- Ladda ner fulltext (pdf) av Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
Ingår i Scientific Reports, 2024
- DOI för Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
- Ladda ner fulltext (pdf) av Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
Ingår i Acta neuropathologica communications, 2024
- DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
- Ladda ner fulltext (pdf) av Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
Ingår i NEUROTHERAPEUTICS, s. 195-206, 2023
- DOI för Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease
- Ladda ner fulltext (pdf) av Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease
Alla publikationer
Artiklar i tidskrift
Ingår i Molecular and Cellular Neuroscience, 2024
- DOI för Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
- Ladda ner fulltext (pdf) av Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
Ingår i Molecular and Cellular Neuroscience, 2024
- DOI för Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
- Ladda ner fulltext (pdf) av Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
Ingår i Scientific Reports, 2024
- DOI för Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
- Ladda ner fulltext (pdf) av Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
Ingår i Acta neuropathologica communications, 2024
- DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
- Ladda ner fulltext (pdf) av Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
Ingår i NEUROTHERAPEUTICS, s. 195-206, 2023
- DOI för Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease
- Ladda ner fulltext (pdf) av Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease
Ingår i AGING BRAIN, 2023
- DOI för Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils
- Ladda ner fulltext (pdf) av Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils
The amyloid-beta pathway in Alzheimer's disease: a plain language summary
Ingår i Neurodegenerative Disease Management, s. 141-149, 2023
- DOI för The amyloid-beta pathway in Alzheimer's disease: a plain language summary
- Ladda ner fulltext (pdf) av The amyloid-beta pathway in Alzheimer's disease: a plain language summary
Ingår i BMC Genomics, 2022
- DOI för Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia
- Ladda ner fulltext (pdf) av Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia
A beta and tau prions feature in the neuropathogenesis of Down syndrome
Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2022
Ingår i Translational Neurodegeneration, 2021
- DOI för Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
- Ladda ner fulltext (pdf) av Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
Ingår i Neurobiology of Disease, 2021
- DOI för ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease
- Ladda ner fulltext (pdf) av ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease
Ingår i Neuroscience Letters, 2021
- DOI för Characterization of monomeric and soluble aggregated A beta in Down's syndrome and Alzheimer's disease brains
- Ladda ner fulltext (pdf) av Characterization of monomeric and soluble aggregated A beta in Down's syndrome and Alzheimer's disease brains
Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease
Ingår i Molecular and Cellular Neuroscience, 2021
Ingår i Science Translational Medicine, 2021
Ingår i Acta neuropathologica communications, 2021
- DOI för Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease
- Ladda ner fulltext (pdf) av Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease
Ingår i Alzheimer's Research & Therapy, 2021
- DOI för A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-A beta protofibril antibody
- Ladda ner fulltext (pdf) av A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-A beta protofibril antibody
Ingår i Nature Genetics, s. 1314-1332, 2020
Ingår i European Journal of Human Genetics, s. 349-357, 2020
- DOI för Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
- Ladda ner fulltext (pdf) av Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
Ingår i ACS Chemical Neuroscience, s. 4460-4468, 2020
- DOI för Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
- Ladda ner fulltext (pdf) av Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
Development of Risk Prediction Equations for Incident Chronic Kidney Disease
Ingår i Journal of the American Medical Association (JAMA), s. 2104-2114, 2019
Ingår i Nature Genetics, s. 414-430, 2019
Mosaic loss of chromosome Y in leukocytes matters
Ingår i Nature Genetics, s. 4-7, 2019
Ingår i Neurobiology of Aging, s. 40-47, 2019
A beta and tau prion-like activities decline with longevity in the Alzheimer's disease human brain
Ingår i Science Translational Medicine, 2019
Ingår i Journal of Alzheimer's Disease, s. 639-651, 2019
- DOI för Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers
- Ladda ner fulltext (pdf) av Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers
Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
Ingår i NEUROLOGY-GENETICS, 2018
- DOI för Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
- Ladda ner fulltext (pdf) av Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
Ingår i Molecular Therapy Nucleic Acids, s. 429-440, 2018
- DOI för CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease
- Ladda ner fulltext (pdf) av CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease
Ingår i Journal of Neuroinflammation, 2018
- DOI för The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death
- Ladda ner fulltext (pdf) av The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death
Ingår i The Journal of Prevention of Alzheimer's Disease, s. 207-212, 2018
Ingår i Journal of Nuclear Medicine, s. 1885-1891, 2018
- DOI för Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
- Ladda ner fulltext (pdf) av Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
Rapid amyloid-β oligomer and protofibril accumulation in traumatic brain injury
Ingår i Brain Pathology, s. 451-462, 2018
Ingår i Alzheimer's Research & Therapy, 2018
- DOI för Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
- Ladda ner fulltext (pdf) av Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
[F-18]Tetrazine-trans-cyclooctene mediated labelling of antibodies for PET imaging of amyloid-beta
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018
Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Ingår i Acta Neuropathologica, s. 41-56, 2018
- DOI för Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
- Ladda ner fulltext (pdf) av Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2018
- DOI för Structural heterogeneity and intersubject variability of A beta in familial and sporadic Alzheimer's disease
- Ladda ner fulltext (pdf) av Structural heterogeneity and intersubject variability of A beta in familial and sporadic Alzheimer's disease
Ingår i Biological Procedures Online, 2017
- DOI för Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
- Ladda ner fulltext (pdf) av Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
Ingår i The Lancet Diabetes and Endocrinology, s. 718-728, 2017
Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 415-416, 2017
Ingår i Atherosclerosis, s. 196-204, 2017
- DOI för Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
- Ladda ner fulltext (pdf) av Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
Ingår i Scientific Data, 2017
- DOI för Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
- Ladda ner fulltext (pdf) av Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Ingår i Nature Genetics, s. 946-+, 2017
Ingår i Nature Genetics, s. 1373-+, 2017
Ingår i Journal of Neuroinflammation, 2017
- DOI för Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
- Ladda ner fulltext (pdf) av Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease
Ingår i BMC Geriatrics, 2017
- DOI för Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease
- Ladda ner fulltext (pdf) av Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease
Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
Ingår i Theranostics, s. 308-318, 2017
- DOI för Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
- Ladda ner fulltext (pdf) av Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
Decreased HHV-6 IgG in Alzheimer's Disease
Ingår i Frontiers in Neurology, 2017
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Ingår i Diabetes, s. 2888-2902, 2017
Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein
Ingår i Cellular and molecular neurobiology, s. 1217-1226, 2017
- DOI för Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein
- Ladda ner fulltext (pdf) av Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein
Ingår i Neuropharmacology, s. 293-300, 2017
Ingår i Cellular and molecular neurobiology, s. 121-131, 2017
Ingår i Glia, 2017
Antibody-based PET radioligands for imaging of amyloid-beta protofibrils
Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 84-84, 2017
Ingår i Diabetes, s. 2019-2032, 2017
Ingår i Journal of the International Neuropsychological Society, s. 195-203, 2017
Ingår i NeuroImage, s. 55-63, 2017
- DOI för A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
- Ladda ner fulltext (pdf) av A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
Ingår i Gene, s. 139-145, 2016
Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
Ingår i American Journal of Human Genetics, s. 1208-1219, 2016
- DOI för Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
- Ladda ner fulltext (pdf) av Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
Ingår i Nature Genetics, s. 1151-1161, 2016
Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
Ingår i Nature Communications, 2016
- DOI för Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
- Ladda ner fulltext (pdf) av Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
Ingår i Molecular Neurodegeneration, 2016
- DOI för Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
- Ladda ner fulltext (pdf) av Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
Ingår i Molecular Neurodegeneration, 2016
The genetic architecture of type 2 diabetes
Ingår i Nature, s. 41-47, 2016
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease
Ingår i PLOS ONE, 2016
- DOI för Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease
- Ladda ner fulltext (pdf) av Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease
Ingår i Alzheimer's Research & Therapy, 2016
- DOI för High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease
- Ladda ner fulltext (pdf) av High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease
Ingår i Alzheimer's Research & Therapy, 2016
- DOI för Safety and tolerability of BAN2401 - a clinical study in Alzheimer's disease with a protofibril selective A beta antibody
- Ladda ner fulltext (pdf) av Safety and tolerability of BAN2401 - a clinical study in Alzheimer's disease with a protofibril selective A beta antibody
Ingår i Journal of Alzheimer's Disease, s. 1671-1686, 2016
Ingår i PROTEOMICS - Clinical Applications, s. 1242-1253, 2016
- DOI för CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease
- Ladda ner fulltext (pdf) av CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease
Ingår i Acta neuropathologica communications, 2016
- DOI för Deposition of C-terminally truncated A beta species A beta 37 and A beta 39 in Alzheimer's disease and transgenic mouse models
- Ladda ner fulltext (pdf) av Deposition of C-terminally truncated A beta species A beta 37 and A beta 39 in Alzheimer's disease and transgenic mouse models
Mutagenesis: smoking is associated with mosaic loss of chromosome Y
Ingår i Science, s. 81-83, 2015
Ingår i American Journal of Kidney Diseases, s. 602-612, 2015
Ingår i American Journal of Kidney Diseases, s. 591-601, 2015
Changes in secondary structure of α-synuclein during oligomerization induced by reactive aldehydes.
Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 336-341, 2015
Ingår i PLOS Genetics, 2015
- DOI för The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
- Ladda ner fulltext (pdf) av The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Ingår i PLOS Genetics, 2015
- DOI för Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
- Ladda ner fulltext (pdf) av Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
Ingår i Leukemia, s. 2069-2074, 2015
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
Ingår i Nature Genetics, s. 1121-1130, 2015
Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins
Ingår i Cell Reports, s. 1134-1146, 2015
- DOI för Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins
- Ladda ner fulltext (pdf) av Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins
Self-reported sleep disturbance is associated with Alzheimer's disease risk in men
Ingår i Alzheimer's & Dementia, s. 1090-1097, 2015
- DOI för Self-reported sleep disturbance is associated with Alzheimer's disease risk in men
- Ladda ner fulltext (pdf) av Self-reported sleep disturbance is associated with Alzheimer's disease risk in men
Ingår i Alzheimer's & Dementia, s. 1180-1190, 2015
Convergent genetic and expression data implicate immunity in Alzheimer's disease
Ingår i Alzheimer's & Dementia, s. 658-671, 2015
A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
Ingår i Genome Biology, 2015
- DOI för A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
- Ladda ner fulltext (pdf) av A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
Ingår i Journal of Alzheimer's Disease, s. 63-72, 2015
- DOI för Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease
- Ladda ner fulltext (pdf) av Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease
Micellar extraction possesses a new advantage for the analysis of Alzheimer's disease brain proteome
Ingår i Analytical and Bioanalytical Chemistry, s. 1041-1057, 2015
Ingår i Journal of Alzheimer's Disease, s. 575-588, 2015
eta-Secretase processing of APP inhibits neuronal activity in the hippocampus
Ingår i Nature, s. 443-447, 2015
Ingår i Journal of Biological Chemistry, s. 14904-14914, 2015
Ingår i Amyloid, s. 76-87, 2014
Ingår i Nature Genetics, s. 624-628, 2014
Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease
Ingår i PLOS ONE, 2014
- DOI för Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease
- Ladda ner fulltext (pdf) av Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease
Ingår i Sleep, s. 195-198, 2014
Ingår i Molecular Neurodegeneration, s. 13, 2014
- DOI för Abundance of A beta(5-x) x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease
- Ladda ner fulltext (pdf) av Abundance of A beta(5-x) x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease
Quantification of the Brain Proteome in Alzheimer's Disease Using Multiplexed Mass Spectrometry
Ingår i Journal of Proteome Research, s. 2056-2068, 2014
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Ingår i PLOS ONE, 2014
- DOI för Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
- Ladda ner fulltext (pdf) av Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Ingår i Journal of Internal Medicine, s. 202-203, 2014
Ingår i Neurobiology of Disease, s. 134-143, 2014
Ingår i Dementia and Geriatric Cognitive Disorders, s. 196-206, 2014
Amyloid-beta-directed immunotherapy for Alzheimer's disease
Ingår i Journal of Internal Medicine, s. 284-295, 2014
- DOI för Amyloid-beta-directed immunotherapy for Alzheimer's disease
- Ladda ner fulltext (pdf) av Amyloid-beta-directed immunotherapy for Alzheimer's disease
Serial propagation of distinct strains of A beta prions from Alzheimer's disease patients
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 10323-10328, 2014
Ingår i Neuroscience Letters, s. 7-12, 2014
Ingår i Journal of Alzheimer's Disease, s. 871-881, 2014
Ingår i BMJ-BRIT MED J, 2014
Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging
Ingår i BMC Neuroscience, s. 148, 2013
- DOI för Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging
- Ladda ner fulltext (pdf) av Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging
Re-evaluation of clinical dementia diagnoses with pittsburgh compound B positron emission tomography
Ingår i Dementia and Geriatric Cognitive Disorders Extra, s. 472-481, 2013
Microglial Markers are Elevated in the Prodromal Phase of Alzheimer's Disease and Vascular Dementia
Ingår i Journal of Alzheimer's Disease, s. 45-53, 2013
Ingår i Journal of Alzheimer's Disease, s. 29-40, 2013
Ingår i Acta neuropathologica communications, s. 60, 2013
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Ingår i Nature Genetics, s. 1452-U206, 2013
Ingår i PLOS ONE, 2013
- DOI för Decreased Proportion of Cytomegalovirus Specific CD8 T-Cells but No Signs of General Immunosenescence in Alzheimer's Disease
- Ladda ner fulltext (pdf) av Decreased Proportion of Cytomegalovirus Specific CD8 T-Cells but No Signs of General Immunosenescence in Alzheimer's Disease
Ingår i PLOS ONE, 2013
- DOI för Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis
- Ladda ner fulltext (pdf) av Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis
Ingår i Amyloid, s. 233-244, 2013
Ingår i Journal of Alzheimer's Disease, s. 673-679, 2013
Ingår i Journal of Neurochemistry, s. 131-144, 2013
Ingår i Molecular Psychiatry, s. 461-470, 2013
Ingår i Journal of Alzheimer's Disease, s. 611-621, 2013
- DOI för Prediction of Mild Cognitive Impairment that Evolves into Alzheimer's Disease Dementia within Two Years using a Gene Expression Signature in Blood: A Pilot Study
- Ladda ner fulltext (pdf) av Prediction of Mild Cognitive Impairment that Evolves into Alzheimer's Disease Dementia within Two Years using a Gene Expression Signature in Blood: A Pilot Study
Ingår i Acta neuropathologica communications, s. 56, 2013
Ingår i Journal of the American Medical Association (JAMA), s. 1941-1951, 2012
Ingår i Journal of Medical Genetics, 2012
Ingår i Acta Neuropathologica, s. 465-478, 2012
Ingår i Neurobiology of Aging, s. 10100-10100000000000000, 2012
Ingår i PLOS ONE, 2012
Ingår i European Journal of Clinical Nutrition, s. 885-890, 2012
Age-related somatic structural changes in the nuclear genome of human blood cells
Ingår i American Journal of Human Genetics, s. 217-228, 2012
Ingår i International Journal of Obesity, s. 119-129, 2012
Ingår i Journal of Neuroscience, s. 11750-11762, 2012
Ingår i Journal of Alzheimer's Disease, s. 273-276, 2012
Ingår i Nature Genetics, s. 659-669, 2012
Immunotherapy in Alzheimer's disease - targeting toxic A beta protofibrils
Ingår i European Neuropsychopharmacology, 2012
Ingår i Journal of Alzheimer's Disease, s. 939-947, 2012
Ingår i Neurobiology of Aging, s. 11590-115900000, 2011
Antibodies against alpha-synuclein reduce oligomerization in living cells
Ingår i PLOS ONE, 2011
- DOI för Antibodies against alpha-synuclein reduce oligomerization in living cells
- Ladda ner fulltext (pdf) av Antibodies against alpha-synuclein reduce oligomerization in living cells
Ingår i Neurodegenerative Diseases, s. 117-123, 2011
Novel Progranulin Mutation Detected in 2 Patients With FTLD
Ingår i Alzheimer Disease and Associated Disorders, s. 173-178, 2011
Ingår i Neurobiology of Aging, s. 1379-1387, 2011
In vivo imaging of astrocytosis in Alzheimer's disease: an ¹¹C-L-deuteriodeprenyl and PIB PET study
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 2202-2208, 2011
Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease
Ingår i Journal of Alzheimer's Disease, s. 711-722, 2011
Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation
Ingår i Neurobiology of Aging, s. 1388-1399, 2011
Ingår i Free Radical Biology & Medicine, s. 428-437, 2011
Gelsolin co-occurs with Lewy bodies in vivo and accelerates alpha-synuclein aggregation in vitro
Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 32-38, 2011
Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort
Ingår i Dementia and Geriatric Cognitive Disorders, s. 460-466, 2011
Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease
Ingår i BMC Neuroscience, s. 124, 2010
Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls
Ingår i Journal of Alzheimer's Disease, s. 1223-1230, 2010
Ingår i Journal of Alzheimer's Disease, s. 471-478, 2010
Ingår i International journal of Alzheimer's disease, s. 936580, 2010
Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 15595-15600, 2010
Ingår i Journal of Biological Chemistry, s. 41517-41524, 2010
Ingår i Dementia and Geriatric Cognitive Disorders, s. 204-212, 2010
CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid
Ingår i Neuroscience Letters, s. 265-267, 2010
PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses
Ingår i Journal of Alzheimer's Disease, s. 509-516, 2010
Heparan sulfate mediates amyloid-beta internalization and cytotoxicity
Ingår i Glycobiology, s. 533-541, 2010
Neurofilament ELISA validation
Ingår i JIM - Journal of Immunological Methods, s. 23-31, 2010
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases
Ingår i Journal of neural transmission, s. 85-96, 2010
Ingår i Acta Neurologica Scandinavica, s. 186-193, 2010
Ingår i European Journal of Neuroscience, s. 852-863, 2010
Ingår i Acta Neurologica Scandinavica, s. 270-277, 2010
Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs
Ingår i Journal of Alzheimer's Disease, s. 1295-1301, 2010
Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study
Ingår i Behavioural Brain Research, s. 83-94, 2010
Ingår i Journal of Alzheimer's Disease, s. 247-255, 2010
Separation and characterization of aggregated species of amyloid-beta peptides
Ingår i Analytical and Bioanalytical Chemistry, s. 2357-2366, 2010
Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice
Ingår i Neuroscience, s. 540-551, 2009
Ingår i BMC Medical Genetics, s. 131, 2009
Ingår i BMC Medical Genetics, s. 122, 2009
Ingår i Dementia and Geriatric Cognitive Disorders, s. 471-475, 2009
Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation
Ingår i Neurogenetics, s. 27-34, 2009
Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men
Ingår i Dementia and Geriatric Cognitive Disorders, s. 59-68, 2009
Circulating immune complexes of A beta and IgM in plasma of patients with Alzheimer's disease
Ingår i Journal of neural transmission, s. 913-920, 2009
Ingår i The FEBS Journal, s. 995-1006, 2009
Oligomerization partially explains the lowering of Aβ42 in Alzheimer's disease cerebrospinal fluid
Ingår i Neuro-degenerative diseases, s. 139-147, 2009
Ingår i Neurobiology of Aging, s. 1393-1405, 2009
Ingår i Diabetologia, s. 1504-1510, 2009
Ingår i Neurobiology of Disease, s. 425-434, 2009
Sällsynta mutationer leder till framtidens behandling
Ingår i Läkartidningen, s. 1396-1400, 2009
Ingår i Journal of Alzheimer's Disease, s. 79-87, 2009
Ingår i Journal of Alzheimer's Disease, s. 71-78, 2009
Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice
Ingår i FEBS Letters, s. 3021-3026, 2009
Ingår i Alzheimer Disease and Associated Disorders, s. 298-300, 2009
Ingår i Annals of Clinical Biochemistry, s. 235-240, 2009
Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 872-876, 2009
Ingår i Dementia and Geriatric Cognitive Disorders, s. 458-464, 2009
Does APOE explain the linkage of Alzheimer’s disease to chromosome 19q13?
Ingår i American Journal of Medical Genetics Part B: Neuropsychiatric Genetics American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, s. 778-83, 2008
Serum cystatin C and the risk of Alzheimer disease in elderly men
Ingår i Neurology, s. 1072-1079, 2008
Ingår i Brain Pathology, s. 548-561, 2008
Ingår i Archives of Neurology, s. 256-63, 2008
Ingår i Lancet Neurology, s. 779-786, 2008
USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study
Ingår i Diabetologia, s. 464-472, 2008
Ingår i European Journal of Human Genetics, s. 171-5, 2008
The tau S305S mutation causes frontotemporal dementia with parkinsonism
Ingår i European Journal of Neurology, s. 156-161, 2008
No association between CALHM1 and Alzheimer's disease risk
Ingår i Cell, s. 993-994, 2008
Impaired insulin secretion increases the risk of Alzheimer disease
Ingår i Neurology, s. 1046-47, 2008
In vivo amyloid imaging with PET in frontotemporal dementia
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 100-106, 2008
Ingår i Archives of Neurology, s. 499-505, 2008
Ingår i ACS Chemical Biology, s. 553-560, 2007
Sensitive ELISA detection of amyloid-β protofibrils in biological samples
Ingår i Journal of Neurochemistry, s. 334-345, 2007
Attenuated amyloid-β aggregation and neurotoxicity owing to methionine oxidation
Ingår i NeuroReport, s. 559-563, 2007
Ingår i European Journal of Neuroscience, s. 882-889, 2007
Ingår i The FEBS Journal, s. 990-1000, 2007
Ingår i Lipids, s. 451-456, 2007
Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity
Ingår i Obesity, s. 1732-1740, 2007
Longitudinal stability of CSF biomarkers in Alzheimer's disease
Ingår i Neuroscience Letters, s. 18-22, 2007
Ingår i Journal of Neurochemistry, s. 854-862, 2007
Underskatta inte värdet av transgena djurmodeller av Alzheimers sjukdom
Ingår i Läkartidningen, s. 798-800, 2007
Increase in beta-Amyloid Levels in Cerebrospinal Fluid of Children with Down Syndrome
Ingår i Dementia and Geriatric Cognitive Disorders, s. 369-374, 2007
Ingår i Neuroscience Letters, s. 127-131, 2007
Reduction of Phosphorylated Tau during Memantine Treatment of Alzheimer's Disease
Ingår i Dementia and Geriatric Cognitive Disorders, s. 247-252, 2007
Association study of cholesterol-related genes in Alzheimer's disease
Ingår i Neurogenetics, s. 179-188, 2007
New Alzheimer's disease locus on chromosome 8
Ingår i Journal of Medical Genetics, s. 931-935, 2006
Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation.
Ingår i Brain Res Bull, s. 79-85, 2006
Ingår i Neurobiol Aging, s. 67-77, 2006
Ingår i FEBS Journal, s. 2618-30, 2006
Ingår i Comb Chem High Throughput Screen, s. 801-6, 2005
Konformationsförändrade proteiner orsakar neurodegenerativa sjukdomar
Ingår i Läkartidningen, s. 3542-3551, 2005
Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
Ingår i Biochem J, s. 545-50, 2005
Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay.
Ingår i Ann Neurol, s. 147-50, 2005
Ingår i World J Biol Psychiatry, s. 69-84, 2005
Clinical and molecular aspects of frontotemporal dementia.
Ingår i Neurodegener Dis, s. 218-24, 2004
Ingår i Neurosci Lett, s. 99-101, 2004
Ingår i J Mol Biol, s. 145-59, 2004
Familial presenile dementia with bitemporal atrophy.
Ingår i Dement Geriatr Cogn Disord, s. 287-92, 2004
The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy.
Ingår i Dement Geriatr Cogn Disord, s. 298-301, 2004
Ingår i Science Translational Medicine
Artiklar, forskningsöversikt
The Amyloid-beta Pathway in Alzheimer's Disease
Ingår i Molecular Psychiatry, s. 5481-5503, 2021
- DOI för The Amyloid-beta Pathway in Alzheimer's Disease
- Ladda ner fulltext (pdf) av The Amyloid-beta Pathway in Alzheimer's Disease
Ingår i Immunotherapy, s. 141-153, 2014
Ingår i ALZHEIMERS RES THER, s. 16, 2014
- DOI för Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease
- Ladda ner fulltext (pdf) av Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease
Ingår i Nutrition reviews, 2010
Animal models of amyloid-β-related pathologies in Alzheimer’s disease
Ingår i The FEBS Journal, s. 1389-1409, 2010
Ingår i Revista de Psiquiatria Clinica, s. 1-16, 2009
Konferensbidrag
Journal of Labelled Compounds and Pharmaceuticals: Neurosciences session
Ingår i ISRS 2019, 2019
Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo
2010
Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo
2010
Details of neuropathology in Arctic Alzheimer's disease
Ingår i Abstracts of the XVIIth International Congress of Neuropathology (ICN 2010), Salzburg, Austria, 11-15 September 2010, s. 22-23, 2010
Morphological and functional differences of aldehyde-induced alpha-synuclein oligomers
Ingår i Amyloid - Journal of Protein Folding Disorders, s. 93-94, 2010
Effects of lipid peroxidation metabolites on alpha-synuclein aggregation
2009