Lars Lannfelt

Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains

Johannesson, Malin; Soderberg, Linda; Zachrisson, Olof; Fritz, Nicolas et al.

Ingår i Molecular and Cellular Neuroscience, 2024

• DOI för Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
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Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice

Rizoska, Biljana; Zachrisson, Olof; Appelkvist, Paulina; Boström, Emma et al.

Ingår i Molecular and Cellular Neuroscience, 2024

• DOI för Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
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Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities

Söderberg, Linda; Johannesson, Malin; Gkanatsiou, Eleni; Nygren, Patrik et al.

Ingår i Scientific Reports, 2024

• DOI för Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
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Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease

Söderberg, Linda; Johannesson, Malin; Nygren, Patrik; Laudon, Hanna et al.

Ingår i NEUROTHERAPEUTICS, s. 195-206, 2023

• DOI för Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease
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Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains

Johannesson, Malin; Soderberg, Linda; Zachrisson, Olof; Fritz, Nicolas et al.

Ingår i Molecular and Cellular Neuroscience, 2024

• DOI för Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
• Ladda ner fulltext (pdf) av Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains

Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice

Rizoska, Biljana; Zachrisson, Olof; Appelkvist, Paulina; Boström, Emma et al.

Ingår i Molecular and Cellular Neuroscience, 2024

• DOI för Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
• Ladda ner fulltext (pdf) av Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice

Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities

Söderberg, Linda; Johannesson, Malin; Gkanatsiou, Eleni; Nygren, Patrik et al.

Ingår i Scientific Reports, 2024

• DOI för Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
• Ladda ner fulltext (pdf) av Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease

Söderberg, Linda; Johannesson, Malin; Nygren, Patrik; Laudon, Hanna et al.

Ingår i NEUROTHERAPEUTICS, s. 195-206, 2023

• DOI för Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease
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Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils

Ekmark-Lewén, Sara; Aniszewska, Agata; Molisak, Agnieszka; Gumucio, Astrid et al.

Ingår i AGING BRAIN, 2023

• DOI för Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils
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The amyloid-beta pathway in Alzheimer's disease: a plain language summary

Hampel, Harald; Hu, Yan; Hardy, John; Blennow, Kaj et al.

Ingår i Neurodegenerative Disease Management, s. 141-149, 2023

• DOI för The amyloid-beta pathway in Alzheimer's disease: a plain language summary
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Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia

Pagnon de la Vega, María; Näslund, Carl; Brundin, RoseMarie; Lannfelt, Lars et al.

Ingår i BMC Genomics, 2022

• DOI för Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia
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A beta and tau prions feature in the neuropathogenesis of Down syndrome

Condello, Carlo; Maxwell, Alison M.; Castillo, Erika; Aoyagi, Atsushi et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI för A beta and tau prions feature in the neuropathogenesis of Down syndrome

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken et al.

Ingår i Translational Neurodegeneration, 2021

• DOI för Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
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ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease

Nordström, Eva; Eriksson, Fredrik; Sigvardson, Jessica; Johannesson, Malin et al.

Ingår i Neurobiology of Disease, 2021

• DOI för ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease
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Characterization of monomeric and soluble aggregated A beta in Down's syndrome and Alzheimer's disease brains

Gkanatsiou, Eleni; Stenh, Charlotte; Portelius, Erik; Johannesson, Malin et al.

Ingår i Neuroscience Letters, 2021

• DOI för Characterization of monomeric and soluble aggregated A beta in Down's syndrome and Alzheimer's disease brains
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Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease

Johannesson, Malin; Sahlin, Charlotte; Söderberg, Linda; Basun, Hans et al.

Ingår i Molecular and Cellular Neuroscience, 2021

• DOI för Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Ingår i Science Translational Medicine, 2021

• DOI för The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease

Zhang, Xiao; O'Callaghan, Paul; Li, Honglian; Tan, Ying-Xia et al.

Ingår i Acta neuropathologica communications, 2021

• DOI för Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease
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A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-A beta protofibril antibody

Swanson, Chad J.; Zhang, Yong; Dhadda, Shobha; Wang, Jinping et al.

Ingår i Alzheimer's Research & Therapy, 2021

• DOI för A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-A beta protofibril antibody
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.

Surendran, Praveen; Feofanova, Elena V; Lahrouchi, Najim; Ntalla, Ioanna et al.

Ingår i Nature Genetics, s. 1314-1332, 2020

• DOI för Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.

Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

Danielsson, Marcus; Halvardson, Jonatan; Davies, Hanna; Moghadam, Behrooz Torabi et al.

Ingår i European Journal of Human Genetics, s. 349-357, 2020

• DOI för Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
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Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

Syvänen, Stina; Fang, Xiaotian T.; Faresjö, Rebecca; Rokka, Johanna et al.

Ingår i ACS Chemical Neuroscience, s. 4460-4468, 2020

• DOI för Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
• Ladda ner fulltext (pdf) av Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

Development of Risk Prediction Equations for Incident Chronic Kidney Disease

Nelson, Robert G.; Grams, Morgan E.; Ballew, Shoshana H.; Sang, Yingying et al.

Ingår i Journal of the American Medical Association (JAMA), s. 2104-2114, 2019

• DOI för Development of Risk Prediction Equations for Incident Chronic Kidney Disease

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Kunkle, Brian W.; Giedraitis, Vilmantas; Kilander, Lena; Brundin, RoseMarie et al.

Ingår i Nature Genetics, s. 414-430, 2019

• DOI för Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Mosaic loss of chromosome Y in leukocytes matters

Forsberg, Lars A.; Halvardson, Jonatan; Rychlicka-Buniowska, Edyta; Danielsson, Marcus et al.

Ingår i Nature Genetics, s. 4-7, 2019

• DOI för Mosaic loss of chromosome Y in leukocytes matters

Longitudinal cognitive decline in autosomal-dominant Alzheimer's disease varies with mutations in APP and PSEN1 genes

Almkvist, Ove; Rodriguez-Vieitez, Elena; Thordardottir, Steinunn; Nordberg, Agneta et al.

Ingår i Neurobiology of Aging, s. 40-47, 2019

• DOI för Longitudinal cognitive decline in autosomal-dominant Alzheimer's disease varies with mutations in APP and PSEN1 genes

A beta and tau prion-like activities decline with longevity in the Alzheimer's disease human brain

Aoyagi, Atsushi; Condello, Carlo; Stöhr, Jan; Yue, Weizhou et al.

Ingår i Science Translational Medicine, 2019

• DOI för A beta and tau prion-like activities decline with longevity in the Alzheimer's disease human brain

Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers

Emami Khoonsari, Payam; Shevchenko, Ganna; Herman, Stephanie; Remnestal, Julia et al.

Ingår i Journal of Alzheimer's Disease, s. 639-651, 2019

• DOI för Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers
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Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

Pulit, Sara L.; Gustafsson, Stefan; Lind, Lars; Lannfelt, Lars et al.

Ingår i NEUROLOGY-GENETICS, 2018

• DOI för Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
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CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease

Gyorgy, Bence; Loov, Camilla; Zaborowski, Mikolaj P.; Takeda, Shuko et al.

Ingår i Molecular Therapy Nucleic Acids, s. 429-440, 2018

• DOI för CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease
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The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death

Söllvander, Sofia; Nikitidou, Elisabeth; Gallasch, Linn; Zysk, Marlena et al.

Ingår i Journal of Neuroinflammation, 2018

• DOI för The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death
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An Action Plan to Face the Challenge of Dementia: INTERNATIONAL STATEMENT ON DEMENTIA from IAP for Health

Chertkow, H.; Hogan, David B.; Black, Sandra; Feldman, Howard et al.

Ingår i The Journal of Prevention of Alzheimer's Disease, s. 207-212, 2018

• DOI för An Action Plan to Face the Challenge of Dementia: INTERNATIONAL STATEMENT ON DEMENTIA from IAP for Health

Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Meier, Silvio R.; Syvänen, Stina; Hultqvist, Greta; Fang, Xiaotian T. et al.

Ingår i Journal of Nuclear Medicine, s. 1885-1891, 2018

• DOI för Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
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Rapid amyloid-β oligomer and protofibril accumulation in traumatic brain injury

Abu Hamdeh, Sami; Rollman Waara, Erik; Möller, Christer; Söderberg, Linda et al.

Ingår i Brain Pathology, s. 451-462, 2018

• DOI för Rapid amyloid-β oligomer and protofibril accumulation in traumatic brain injury

Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Syvänen, Stina; Hultqvist, Greta; Gustavsson, Tobias; Gumucio, Astrid et al.

Ingår i Alzheimer's Research & Therapy, 2018

• DOI för Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
• Ladda ner fulltext (pdf) av Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

[F-18]Tetrazine-trans-cyclooctene mediated labelling of antibodies for PET imaging of amyloid-beta

Eriksson, Jonas; Fang, Xiaotian T.; Hultqvist, Greta; Olberg, D. E. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018

Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Sinha, Maitrayee Sardar; Ansell-Schultz, Anna; Civitelli, Livia; Hildesjo, Camilla et al.

Ingår i Acta Neuropathologica, s. 41-56, 2018

• DOI för Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
• Ladda ner fulltext (pdf) av Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Structural heterogeneity and intersubject variability of A beta in familial and sporadic Alzheimer's disease

Condello, Carlo; Lemmin, Thomas; Stöhr, Jan; Nick, Mimi et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2018

• DOI för Structural heterogeneity and intersubject variability of A beta in familial and sporadic Alzheimer's disease
• Ladda ner fulltext (pdf) av Structural heterogeneity and intersubject variability of A beta in familial and sporadic Alzheimer's disease

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

Fang, Xiaotian T.; Sehlin, Dag; Lannfelt, Lars; Syvänen, Stina et al.

Ingår i Biological Procedures Online, 2017

• DOI för Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
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Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data.

Matsushita, Kunihiro; Ballew, Shoshana H; Coresh, Josef; Arima, Hisatomi et al.

Ingår i The Lancet Diabetes and Endocrinology, s. 718-728, 2017

• DOI för Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data.

Efficient clearance of Amyloid-beta protofibrils in APP-transgenic mice treated with a brain penetrating bifunctional antibody

Sehlin, Dag; Hultqvist, Greta; Gumucio, Astrid; Laudon, H. et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 415-416, 2017

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Strawbridge, Rona J.; Silveira, Angela; den Hoed, Marcel; Gustafsson, Stefan et al.

Ingår i Atherosclerosis, s. 196-204, 2017

• DOI för Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
• Ladda ner fulltext (pdf) av Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M. et al.

Ingår i Scientific Data, 2017

• DOI för Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
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Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Christophersen, Ingrid E.; Rienstra, Michiel; Roselli, Carolina; Yin, Xiaoyan et al.

Ingår i Nature Genetics, s. 946-+, 2017

• DOI för Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sims, Rebecca; van der Lee, Sven J.; Naj, Adam C.; Bellenguez, Celine et al.

Ingår i Nature Genetics, s. 1373-+, 2017

• DOI för Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Gustafsson, Gabriel; Lindström, Veronica; Rostami, Jinar; Nordström, Eva et al.

Ingår i Journal of Neuroinflammation, 2017

• DOI för Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
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Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease

Velickaite, Vilma; Giedraitis, Vilmantas; Ström, K; Alafuzoff, Irina et al.

Ingår i BMC Geriatrics, 2017

• DOI för Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease
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Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars et al.

Ingår i Theranostics, s. 308-318, 2017

• DOI för Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
• Ladda ner fulltext (pdf) av Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Decreased HHV-6 IgG in Alzheimer's Disease

Westman, Gabriel; Blomberg, Jonas; Yun, Zhibing; Lannfelt, Lars et al.

Ingår i Frontiers in Neurology, 2017

• DOI för Decreased HHV-6 IgG in Alzheimer's Disease

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Scott, Robert A.; Scott, Laura J.; Maegi, Reedik; Marullo, Letizia et al.

Ingår i Diabetes, s. 2888-2902, 2017

• DOI för An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein

Almandoz-Gil, Leire; Lindström, Veronica; Sigvardson, Jessica; Kahle, Philipp J. et al.

Ingår i Cellular and molecular neurobiology, s. 1217-1226, 2017

• DOI för Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein
• Ladda ner fulltext (pdf) av Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Ingår i Neuropharmacology, s. 293-300, 2017

• DOI för Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Cellular Uptake of alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of alpha-Synuclein and Mediated via Fc gamma Receptors

Gustafsson, Gabriel; Eriksson, Fredrik; Möller, Christer; da Fonseca, Tomas Lopes et al.

Ingår i Cellular and molecular neurobiology, s. 121-131, 2017

• DOI för Cellular Uptake of alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of alpha-Synuclein and Mediated via Fc gamma Receptors

The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta induced apoptosis

Nikitidou, Elisabeth; Söllvander, Sofia; Zyśk, Marlena; Söderberg, L. et al.

Ingår i Glia, 2017

• DOI för The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta induced apoptosis

Antibody-based PET radioligands for imaging of amyloid-beta protofibrils

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Falting, J. et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 84-84, 2017

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling et al.

Ingår i Diabetes, s. 2019-2032, 2017

• DOI för A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Predicting Cognitive Decline across Four Decades in Mutation Carriers and Non-carriers in Autosomal-Dominant Alzheimer's Disease

Almkvist, Ove; Rodriguez-Vieitez, Elena; Thordardottir, Steinunn; Amberla, Kaarina et al.

Ingår i Journal of the International Neuropsychological Society, s. 195-203, 2017

• DOI för Predicting Cognitive Decline across Four Decades in Mutation Carriers and Non-carriers in Autosomal-Dominant Alzheimer's Disease

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R. et al.

Ingår i NeuroImage, s. 55-63, 2017

• DOI för A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
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mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts

Caruso, Vanni; Sreedharan, Smitha; Carlini, Valeria P.; Jacobsson, Josefin A. et al.

Ingår i Gene, s. 139-145, 2016

• DOI för mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

Dumanski, Jan P.; Lambert, Jean-Charles; Rasi, Chiara; Giedraitis, Vilmantas et al.

Ingår i American Journal of Human Genetics, s. 1208-1219, 2016

• DOI för Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
• Ladda ner fulltext (pdf) av Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen et al.

Ingår i Nature Genetics, s. 1151-1161, 2016

• DOI för Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Sehlin, Dag; Fang, Xiaotian T.; Cato, Linda; Antoni, Gunnar et al.

Ingår i Nature Communications, 2016

• DOI för Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
• Ladda ner fulltext (pdf) av Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, Sofia; Nikitidou, Elisabeth; Brolin, Robin; Soderberg, Linda et al.

Ingår i Molecular Neurodegeneration, 2016

• DOI för Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
• Ladda ner fulltext (pdf) av Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, Sofia; Nikitidou, Elisabeth; Brolin, Robin; Söderberg, Linda et al.

Ingår i Molecular Neurodegeneration, 2016

The genetic architecture of type 2 diabetes

Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M.; Mahajan, Anubha et al.

Ingår i Nature, s. 41-47, 2016

• DOI för The genetic architecture of type 2 diabetes

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease

Emami Khoonsari, Payam; Haggmark, Anna; Lönnberg, Maria; Mikus, Maria et al.

Ingår i PLOS ONE, 2016

• DOI för Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease
• Ladda ner fulltext (pdf) av Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease

High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease

Gunnarsson, Malin Degerman; Ingelsson, Martin; Blennow, Kaj; Basun, Hans et al.

Ingår i Alzheimer's Research & Therapy, 2016

• DOI för High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease
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Safety and tolerability of BAN2401 - a clinical study in Alzheimer's disease with a protofibril selective A beta antibody

Logovinsky, Veronika; Satlin, Andrew; Lai, Robert; Swanson, Chad et al.

Ingår i Alzheimer's Research & Therapy, 2016

• DOI för Safety and tolerability of BAN2401 - a clinical study in Alzheimer's disease with a protofibril selective A beta antibody
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Increased levels of extracellular microvesicle markers and decreased levels of endocytic/exocytic proteins in the Alzheimer’s disease brain

Sravani, Musunuri; Emami Khoonsari, Payam; Mikus, Maria; Wetterhall, Magnus et al.

Ingår i Journal of Alzheimer's Disease, s. 1671-1686, 2016

• DOI för Increased levels of extracellular microvesicle markers and decreased levels of endocytic/exocytic proteins in the Alzheimer’s disease brain

CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease

Remnestål, Julia; Just, David; Mitsios, Nicholas; Fredolini, Claudia et al.

Ingår i PROTEOMICS - Clinical Applications, s. 1242-1253, 2016

• DOI för CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease
• Ladda ner fulltext (pdf) av CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease

Deposition of C-terminally truncated A beta species A beta 37 and A beta 39 in Alzheimer's disease and transgenic mouse models

Reinert, Jochim; Richard, Bernhard C.; Klafki, Hans W.; Friedrich, Beate et al.

Ingår i Acta neuropathologica communications, 2016

• DOI för Deposition of C-terminally truncated A beta species A beta 37 and A beta 39 in Alzheimer's disease and transgenic mouse models
• Ladda ner fulltext (pdf) av Deposition of C-terminally truncated A beta species A beta 37 and A beta 39 in Alzheimer's disease and transgenic mouse models

Mutagenesis: smoking is associated with mosaic loss of chromosome Y

Dumanski, Jan P.; Rasi, Chiara; Lönn, Mikael; Davies, Hanna et al.

Ingår i Science, s. 81-83, 2015

• DOI för Mutagenesis: smoking is associated with mosaic loss of chromosome Y

A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury.

James, Matthew T; Grams, Morgan E; Woodward, Mark; Elley, C Raina et al.

Ingår i American Journal of Kidney Diseases, s. 602-612, 2015

• DOI för A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury.

A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury

Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H; Gansevoort, Ron T et al.

Ingår i American Journal of Kidney Diseases, s. 591-601, 2015

• DOI för A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury

Changes in secondary structure of α-synuclein during oligomerization induced by reactive aldehydes.

Cai, Yixiao; Lendel, Christofer; Österlund, Lars; Kasrayan, Alex et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 336-341, 2015

• DOI för Changes in secondary structure of α-synuclein during oligomerization induced by reactive aldehydes.

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, Thomas W.; Justice, Anne E.; Graff, Mariaelisa; Barata, Llilda et al.

Ingår i PLOS Genetics, 2015

• DOI för The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
• Ladda ner fulltext (pdf) av The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

Mahajan, Anubha; Sim, Xueling; Ng, Hui Jin; Manning, Alisa et al.

Ingår i PLOS Genetics, 2015

• DOI för Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
• Ladda ner fulltext (pdf) av Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus

Chase, A.; Leung, W.; Tapper, W.; Jones, A. V. et al.

Ingår i Leukemia, s. 2069-2074, 2015

• DOI för Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

Nikpay, Majid; Goel, Anuj; Won, Hong-Hee; Hall, Leanne M. et al.

Ingår i Nature Genetics, s. 1121-1130, 2015

• DOI för A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

Hosp, Fabian; Vossfeldt, Hannes; Heinig, Matthias; Vasiljevic, Djordje et al.

Ingår i Cell Reports, s. 1134-1146, 2015

• DOI för Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins
• Ladda ner fulltext (pdf) av Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

Self-reported sleep disturbance is associated with Alzheimer's disease risk in men

Benedict, Christian; Byberg, Liisa; Cedernaes, Jonathan; Hogenkamp, Pleunie S et al.

Ingår i Alzheimer's & Dementia, s. 1090-1097, 2015

• DOI för Self-reported sleep disturbance is associated with Alzheimer's disease risk in men
• Ladda ner fulltext (pdf) av Self-reported sleep disturbance is associated with Alzheimer's disease risk in men

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

Kvartsberg, Hlin; Duits, Flora H.; Ingelsson, Martin; Andreasen, Niels et al.

Ingår i Alzheimer's & Dementia, s. 1180-1190, 2015

• DOI för Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

Convergent genetic and expression data implicate immunity in Alzheimer's disease

Jones, Lesley; Lambert, Jean-Charles; Wang, Li-San; Choi, Seung-Hoan et al.

Ingår i Alzheimer's & Dementia, s. 658-671, 2015

• DOI för Convergent genetic and expression data implicate immunity in Alzheimer's disease

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status

Sood, Sanjana; Gallagher, Iain J.; Lunnon, Katie; Rullman, Eric et al.

Ingår i Genome Biology, 2015

• DOI för A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
• Ladda ner fulltext (pdf) av A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status

Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease

Söllvander, Sofia; Ekholm-Pettersson, Frida; Brundin, Rose-Marie; Westman, Gabriel et al.

Ingår i Journal of Alzheimer's Disease, s. 63-72, 2015

• DOI för Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease
• Ladda ner fulltext (pdf) av Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease

Micellar extraction possesses a new advantage for the analysis of Alzheimer's disease brain proteome

Musunuri, Sravani; Kultima, Kim; Richard, Bernhard Clemens; Ingelsson, Martin et al.

Ingår i Analytical and Bioanalytical Chemistry, s. 1041-1057, 2015

• DOI för Micellar extraction possesses a new advantage for the analysis of Alzheimer's disease brain proteome

The Murine Version of BAN2401 (mAb158) Selectively Reduces Amyloid-beta Protofibrils in Brain and Cerebrospinal Fluid of tg-ArcSwe Mice

Tucker, Stina; Moller, Christer; Tegerstedt, Karin; Lord, Anna et al.

Ingår i Journal of Alzheimer's Disease, s. 575-588, 2015

• DOI för The Murine Version of BAN2401 (mAb158) Selectively Reduces Amyloid-beta Protofibrils in Brain and Cerebrospinal Fluid of tg-ArcSwe Mice

eta-Secretase processing of APP inhibits neuronal activity in the hippocampus

Willem, Michael; Tahirovic, Sabina; Busche, Marc Aurel; Ovsepian, Saak V. et al.

Ingår i Nature, s. 443-447, 2015

• DOI för eta-Secretase processing of APP inhibits neuronal activity in the hippocampus

Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

O'Callaghan, Paul; Li, Jin-Ping; Lannfelt, Lars; Lindahl, Ulf et al.

Ingår i Journal of Biological Chemistry, s. 14904-14914, 2015

• DOI för Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

O'Callaghan, Paul; Noborn, Fredrik; Sehlin, Dag; Li, Jin-ping et al.

Ingår i Amyloid, s. 76-87, 2014

• DOI för Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Forsberg, Lars A.; Rasi, Chiara; Malmqvist, Niklas; Davies, Hanna et al.

Ingår i Nature Genetics, s. 624-628, 2014

• DOI för Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease

Westman, Gabriel; Berglund, David; Widen, Johan; Ingelsson, Martin et al.

Ingår i PLOS ONE, 2014

• DOI för Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease
• Ladda ner fulltext (pdf) av Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease

Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men

Benedict, Christian; Cedernaes, Jonathan; Giedraitis, Vilmantas; Nilsson, Emil K et al.

Ingår i Sleep, s. 195-198, 2014

• DOI för Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men

Abundance of A beta(5-x) x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease

Guzman, Erika Avendano; Bouter, Yvonne; Richard, Bernhard C.; Lannfelt, Lars et al.

Ingår i Molecular Neurodegeneration, s. 13, 2014

• DOI för Abundance of A beta(5-x) x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease
• Ladda ner fulltext (pdf) av Abundance of A beta(5-x) x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease

Quantification of the Brain Proteome in Alzheimer's Disease Using Multiplexed Mass Spectrometry

Musunuri, Sravani; Wetterhall, Magnus; Ingelsson, Martin; Lannfelt, Lars et al.

Ingår i Journal of Proteome Research, s. 2056-2068, 2014

• DOI för Quantification of the Brain Proteome in Alzheimer's Disease Using Multiplexed Mass Spectrometry

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

Escott-Price, Valentina; Bellenguez, Celine; Wang, Li-San; Choi, Seung-Hoan et al.

Ingår i PLOS ONE, 2014

• DOI för Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
• Ladda ner fulltext (pdf) av Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

9th Key symposium Introduction: Updating Alzheimer's disease diagnosis implications for prevention and treatment

Kivipelto, M.; Mangialasche, F.; Solomon, A.; Johansson, G. et al.

Ingår i Journal of Internal Medicine, s. 202-203, 2014

• DOI för 9th Key symposium Introduction: Updating Alzheimer's disease diagnosis implications for prevention and treatment

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

Lindström, Veronica; Fagerqvist, Therese; Eva, Nordström; Eriksson, Fredrik et al.

Ingår i Neurobiology of Disease, s. 134-143, 2014

• DOI för Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

High Tau Levels in Cerebrospinal Fluid Predict Rapid Decline and Increased Dementia Mortality in Alzheimer's Disease

Degerman Gunnarsson, Malin; Lannfelt, Lars; Ingelsson, Martin; Basun, Hans et al.

Ingår i Dementia and Geriatric Cognitive Disorders, s. 196-206, 2014

• DOI för High Tau Levels in Cerebrospinal Fluid Predict Rapid Decline and Increased Dementia Mortality in Alzheimer's Disease

Amyloid-beta-directed immunotherapy for Alzheimer's disease

Lannfelt, Lars; Relkin, N. R.; Siemers, E. R.

Ingår i Journal of Internal Medicine, s. 284-295, 2014

• DOI för Amyloid-beta-directed immunotherapy for Alzheimer's disease
• Ladda ner fulltext (pdf) av Amyloid-beta-directed immunotherapy for Alzheimer's disease

Serial propagation of distinct strains of A beta prions from Alzheimer's disease patients

Watts, Joel C.; Condello, Carlo; Stoehr, Jan; Oehler, Abby et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 10323-10328, 2014

• DOI för Serial propagation of distinct strains of A beta prions from Alzheimer's disease patients

The amyloid-beta degradation pattern in plasma A possible tool for clinical trials in Alzheimer's disease

Pannee, Josef; Tornqvist, Ulrika; Westerlund, Anni; Ingelsson, Martin et al.

Ingår i Neuroscience Letters, s. 7-12, 2014

• DOI för The amyloid-beta degradation pattern in plasma A possible tool for clinical trials in Alzheimer's disease

A beta(38) in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models

Reinert, Jochim; Martens, Henrik; Huettenrauch, Melanie; Kolbow, Tekla et al.

Ingår i Journal of Alzheimer's Disease, s. 871-881, 2014

• DOI för A beta(38) in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Holmes, Michael V.; Dale, Caroline E.; Zuccolo, Luisa; Silverwood, Richard J. et al.

Ingår i BMJ-BRIT MED J, 2014

• DOI för Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging

Gumucio, Astrid; Lannfelt, Lars; Nilsson, Lars N. G.

Ingår i BMC Neuroscience, s. 148, 2013

• DOI för Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging
• Ladda ner fulltext (pdf) av Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging

Re-evaluation of clinical dementia diagnoses with pittsburgh compound B positron emission tomography

Degerman Gunnarsson, Malin; Lindau, M; Santillo, A F; Wall, Anders et al.

Ingår i Dementia and Geriatric Cognitive Disorders Extra, s. 472-481, 2013

• DOI för Re-evaluation of clinical dementia diagnoses with pittsburgh compound B positron emission tomography

Microglial Markers are Elevated in the Prodromal Phase of Alzheimer's Disease and Vascular Dementia

Olsson, Bob; Hertze, Joakim; Lautner, Ronald; Zetterberg, Henrik et al.

Ingår i Journal of Alzheimer's Disease, s. 45-53, 2013

• DOI för Microglial Markers are Elevated in the Prodromal Phase of Alzheimer's Disease and Vascular Dementia

Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain

Magnusson, Kristina; Sehlin, Dag; Syvänen, Stina; Svedberg, Marie M. et al.

Ingår i Journal of Alzheimer's Disease, s. 29-40, 2013

• DOI för Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain

The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ

Kalimo, Hannu; Lalowski, Maciej; Bogdanovic, Nenad; Philipson, Ola et al.

Ingår i Acta neuropathologica communications, s. 60, 2013

• DOI för The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Lambert, Jean-Charles; Ibrahim-Verbaas, Carla A.; Harold, Denise; Naj, Adam C. et al.

Ingår i Nature Genetics, s. 1452-U206, 2013

• DOI för Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Decreased Proportion of Cytomegalovirus Specific CD8 T-Cells but No Signs of General Immunosenescence in Alzheimer's Disease

Westman, Gabriel; Lidehall, Anna-Karin; Magnusson, Peetra; Ingelsson, Martin et al.

Ingår i PLOS ONE, 2013

• DOI för Decreased Proportion of Cytomegalovirus Specific CD8 T-Cells but No Signs of General Immunosenescence in Alzheimer's Disease
• Ladda ner fulltext (pdf) av Decreased Proportion of Cytomegalovirus Specific CD8 T-Cells but No Signs of General Immunosenescence in Alzheimer's Disease

Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis

Rubio-Moscardo, Fanny; Seto-Salvia, Nuria; Pera, Marta; Bosch-Morato, Monica et al.

Ingår i PLOS ONE, 2013

• DOI för Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis
• Ladda ner fulltext (pdf) av Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis

Off-pathway alpha-synuclein oligomers seem to alter alpha-synuclein turnover in a cell model but lack seeding capability in vivo

Fagerqvist, Therese; Näsström, Thomas; Ihse, Elisabet; Lindström, Veronica et al.

Ingår i Amyloid, s. 233-244, 2013

• DOI för Off-pathway alpha-synuclein oligomers seem to alter alpha-synuclein turnover in a cell model but lack seeding capability in vivo

Cerebrospinal Fluid Levels of Heart Fatty Acid Binding Protein are Elevated Prodromally in Alzheimer's Disease and Vascular Dementia

Olsson, Bob; Hertze, Joakim; Ohlsson, Mattias; Nägga, Katarina et al.

Ingår i Journal of Alzheimer's Disease, s. 673-679, 2013

• DOI för Cerebrospinal Fluid Levels of Heart Fatty Acid Binding Protein are Elevated Prodromally in Alzheimer's Disease and Vascular Dementia

Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

Fagerqvist, Therese; Lindström, Veronica; Nordstrom, Eva; Lord, Anna et al.

Ingår i Journal of Neurochemistry, s. 131-144, 2013

• DOI för Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

Lambert, J-C; Grenier-Boley, B.; Harold, D.; Zelenika, D. et al.

Ingår i Molecular Psychiatry, s. 461-470, 2013

• DOI för Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

Prediction of Mild Cognitive Impairment that Evolves into Alzheimer's Disease Dementia within Two Years using a Gene Expression Signature in Blood: A Pilot Study

Roed, Line; Grave, Gisle; Lindahl, Torbjorn; Rian, Edith et al.

Ingår i Journal of Alzheimer's Disease, s. 611-621, 2013

• DOI för Prediction of Mild Cognitive Impairment that Evolves into Alzheimer's Disease Dementia within Two Years using a Gene Expression Signature in Blood: A Pilot Study
• Ladda ner fulltext (pdf) av Prediction of Mild Cognitive Impairment that Evolves into Alzheimer's Disease Dementia within Two Years using a Gene Expression Signature in Blood: A Pilot Study

N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

Antonios, Gregory; Saiepour, Nasrin; Bouter, Yvonne; Richard, Bernhard C et al.

Ingår i Acta neuropathologica communications, s. 56, 2013

• DOI för N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate

Matsushita, Kunihiro; Mahmoodi, Bakhtawar K; Woodward, Mark; Emberson, Jonathan R et al.

Ingår i Journal of the American Medical Association (JAMA), s. 1941-1951, 2012

• DOI för Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate

Age-related accumulation of somatic structural changes in the nuclear genome of human blood cells in vivo

Dumanski, Jan P.; Forsberg, L. A.; Rasi, C.; Razzaghian, H. R. et al.

Ingår i Journal of Medical Genetics, 2012

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain

Zhang, Xiao; Wang, Bo; O'Callaghan, Paul; Hjertstrom, Elina et al.

Ingår i Acta Neuropathologica, s. 465-478, 2012

• DOI för Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain

The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ

Philipson, Ola; Lord, Anna; Lalowski, Maciej; Soliymani, Rabah et al.

Ingår i Neurobiology of Aging, s. 10100-10100000000000000, 2012

• DOI för The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ

Large Aggregates Are the Major Soluble Ab Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Sehlin, Dag; Englund, Hillevi; Simu, Barbro; Karlsson, Mikael et al.

Ingår i PLOS ONE, 2012

• DOI för Large Aggregates Are the Major Soluble Ab Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Serum fatty-acid composition and the risk of Alzheimer’s disease: a longitudinal population based study

Rönnemaa, Elina; Zethelius, Björn; Vessby, Bengt; Lannfelt, Lars et al.

Ingår i European Journal of Clinical Nutrition, s. 885-890, 2012

• DOI för Serum fatty-acid composition and the risk of Alzheimer’s disease: a longitudinal population based study

Age-related somatic structural changes in the nuclear genome of human blood cells

Forsberg, Lars A.; Rasi, Chiara; Razzaghian, Hamid R; Pakalapati, Geeta et al.

Ingår i American Journal of Human Genetics, s. 217-228, 2012

• DOI för Age-related somatic structural changes in the nuclear genome of human blood cells

Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children

Jacobsson, Josefin; Rask-Andersen, Mathias; Risérus, Ulf; Moschonis, G et al.

Ingår i International Journal of Obesity, s. 119-129, 2012

• DOI för Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Diogenes, Maria Jose; Dias, Raquel B.; Rombo, Diogo M.; Miranda, Hugo Vicente et al.

Ingår i Journal of Neuroscience, s. 11750-11762, 2012

• DOI för Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Extreme Stability of Chitotriosidase in Cerebrospinal Fluid makes it a Suitable Marker for Microglial Activation in Clinical Trials

Olsson, Bob; Malmestrom, Clas; Basun, Hans; Annas, Peter et al.

Ingår i Journal of Alzheimer's Disease, s. 273-276, 2012

• DOI för Extreme Stability of Chitotriosidase in Cerebrospinal Fluid makes it a Suitable Marker for Microglial Activation in Clinical Trials

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Manning, Alisa K.; Hivert, Marie-France; Scott, Robert A.; Grimsby, Jonna L. et al.

Ingår i Nature Genetics, s. 659-669, 2012

• DOI för A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Immunotherapy in Alzheimer's disease - targeting toxic A beta protofibrils

Lannfelt, Lars

Ingår i European Neuropsychopharmacology, 2012

• DOI för Immunotherapy in Alzheimer's disease - targeting toxic A beta protofibrils

Longitudinal Stability Evaluation of Biomarkers and Their Correlation in Cerebrospinal Fluid and Plasma from Patients with Alzheimer's Disease

Höglund, Kina; Bogstedt, Anna; Fabre, Susanne; Aziz, Ali et al.

Ingår i Journal of Alzheimer's Disease, s. 939-947, 2012

• DOI för Longitudinal Stability Evaluation of Biomarkers and Their Correlation in Cerebrospinal Fluid and Plasma from Patients with Alzheimer's Disease

The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men

Benedict, Christian; Jacobsson, Josefin A; Rönnemaa, Elina; Sällman Almén, Markus et al.

Ingår i Neurobiology of Aging, s. 11590-115900000, 2011

• DOI för The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men

Antibodies against alpha-synuclein reduce oligomerization in living cells

Näsström, Thomas; Goncalves, Susana; Sahlin, Charlotte; Nordström, Eva et al.

Ingår i PLOS ONE, 2011

• DOI för Antibodies against alpha-synuclein reduce oligomerization in living cells
• Ladda ner fulltext (pdf) av Antibodies against alpha-synuclein reduce oligomerization in living cells

Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-A beta Antibodies

Sehlin, Dag; Hedlund, Marie; Lord, Anna; Englund, Hillevi et al.

Ingår i Neurodegenerative Diseases, s. 117-123, 2011

• DOI för Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-A beta Antibodies

Novel Progranulin Mutation Detected in 2 Patients With FTLD

Skoglund, Lena; Matsui, Toshifumi; Freeman, Stefanie H.; Wallin, Anders et al.

Ingår i Alzheimer Disease and Associated Disorders, s. 173-178, 2011

• DOI för Novel Progranulin Mutation Detected in 2 Patients With FTLD

Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Abeta in plasma of patients with Alzheimer's disease

Marcello, Andrea; Wirths, Oliver; Schneider-Axmann, Thomas; Degerman-Gunnarsson, Malin et al.

Ingår i Neurobiology of Aging, s. 1379-1387, 2011

• DOI för Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Abeta in plasma of patients with Alzheimer's disease

In vivo imaging of astrocytosis in Alzheimer's disease: an ¹¹C-L-deuteriodeprenyl and PIB PET study

Santillo, Alexander Frizell; Gambini, Juan Pablo; Lannfelt, Lars; Långström, Bengt et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 2202-2208, 2011

• DOI för In vivo imaging of astrocytosis in Alzheimer's disease: an ¹¹C-L-deuteriodeprenyl and PIB PET study

Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease

Yang, Jing; Lunde, Lisa K; Nuntagij, Paworn; Oguchi, Tomohiro et al.

Ingår i Journal of Alzheimer's Disease, s. 711-722, 2011

• DOI för Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease

Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation

Schöll, Michael; Almkvist, Ove; Axelman, Karin; Stefanova, Elka et al.

Ingår i Neurobiology of Aging, s. 1388-1399, 2011

• DOI för Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

Näsström, Thomas; Fagerqvist, Therese; Barbu, Mikael; Karlsson, Mikael et al.

Ingår i Free Radical Biology & Medicine, s. 428-437, 2011

• DOI för The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

Gelsolin co-occurs with Lewy bodies in vivo and accelerates alpha-synuclein aggregation in vitro

Welander, Hedvig; Bontha, Sai Vineela; Näsström, Tomas; Karlsson, Mikael et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 32-38, 2011

• DOI för Gelsolin co-occurs with Lewy bodies in vivo and accelerates alpha-synuclein aggregation in vitro

Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort

Rönnemaa, Elina; Zethelius, Björn; Lannfelt, Lars; Kilander, Lena

Ingår i Dementia and Geriatric Cognitive Disorders, s. 460-466, 2011

• DOI för Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort

Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease

Kamali-Moghaddam, Masood; Ekholm Pettersson, Frida; Wu, Di; Englund, Hillevi et al.

Ingår i BMC Neuroscience, s. 124, 2010

• DOI för Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease

Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

Sundelöf, Johan; Sundström, Johan; Hansson, Oskar; Eriksdotter-Jönhagen, Maria et al.

Ingår i Journal of Alzheimer's Disease, s. 1223-1230, 2010

• DOI för Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

Cystatin C Levels are Positively Correlated with both Aβ₄₂ and Tau Levels in Cerebrospinal Fluid in Persons with Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls

Sundelöf, Johan; Sundstrom, Johan; Hansson, Oskar; Eriksdotter-Jönhagen, Maria et al.

Ingår i Journal of Alzheimer's Disease, s. 471-478, 2010

• DOI för Cystatin C Levels are Positively Correlated with both Aβ₄₂ and Tau Levels in Cerebrospinal Fluid in Persons with Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

Blom, Elin S; Wang, Yijing; Skoglund, Lena; Hansson, Anita C et al.

Ingår i International journal of Alzheimer's disease, s. 936580, 2010

• DOI för Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

Sandberg, Anders; Luheshi, Leila M.; Söllvander, Sofia; Pereira de Barros, Teresa et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 15595-15600, 2010

• DOI för Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

Identification of low molecular weight pyroglutamate Aβ oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

Wirths, Oliver; Erck, Christian; Martens, Henrik; Harmeier, Anja et al.

Ingår i Journal of Biological Chemistry, s. 41517-41524, 2010

• DOI för Identification of low molecular weight pyroglutamate Aβ oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study

Degerman Gunnarsson, Malin; Lindau, Maria; Wall, Anders; Blennow, K et al.

Ingår i Dementia and Geriatric Cognitive Disorders, s. 204-212, 2010

• DOI för Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid

Giedraitis, Vilmantas; Glaser, Anna; Sarajärvi, Timo; Brundin, RoseMarie et al.

Ingår i Neuroscience Letters, s. 265-267, 2010

• DOI för CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

Faux, Noel G; Ritchie, Craig W; Gunn, Adam; Rembach, Alan et al.

Ingår i Journal of Alzheimer's Disease, s. 509-516, 2010

• DOI för PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

Sandwall, Elina; O'Callaghan, Paul; Zhang, Xiao; Lindahl, Ulf et al.

Ingår i Glycobiology, s. 533-541, 2010

• DOI för Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

Neurofilament ELISA validation

Petzold, Axel; Altintas, Ayse; Andreoni, Laura; Bartos, Ales et al.

Ingår i JIM - Journal of Immunological Methods, s. 23-31, 2010

• DOI för Neurofilament ELISA validation

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

Wirths, Oliver; Bethge, Tobias; Marcello, Andrea; Harmeier, Anja et al.

Ingår i Journal of neural transmission, s. 85-96, 2010

• DOI för Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Wiig, E H; Annas, P; Basun, H; Andreasen, N et al.

Ingår i Acta Neurologica Scandinavica, s. 186-193, 2010

• DOI för The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders

Israelsson, Charlotte; Bengtsson, Henrik; Lobell, Anna; Nilsson, Lars N. G. et al.

Ingår i European Journal of Neuroscience, s. 852-863, 2010

• DOI för Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders

Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Wesnes, K; Edgar, C.; Andreasen, N.; Annas, P. et al.

Ingår i Acta Neurologica Scandinavica, s. 270-277, 2010

• DOI för Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs

Sehlin, Dag; Söllvander, Sofia; Paulie, Staffan; Brundin, RoseMarie et al.

Ingår i Journal of Alzheimer's Disease, s. 1295-1301, 2010

• DOI för Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs

Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study

Codita, Alina; Gumucio, Astrid; Lannfelt, Lars; Gellerfors, Pär et al.

Ingår i Behavioural Brain Research, s. 83-94, 2010

• DOI för Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study

The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study

Lambert, Jean-Charles; Sleegers, Kristel; Gonzalez-Perez, Antonio; Ingelsson, Martin et al.

Ingår i Journal of Alzheimer's Disease, s. 247-255, 2010

• DOI för The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study

Separation and characterization of aggregated species of amyloid-beta peptides

Wiberg, Henning; Ek, Patrik; Ekholm Pettersson, Frida; Lannfelt, Lars et al.

Ingår i Analytical and Bioanalytical Chemistry, s. 2357-2366, 2010

• DOI för Separation and characterization of aggregated species of amyloid-beta peptides

Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice

Marklund, Niklas; Morales, D; Clausen, Fredrik; Hånell, Anders et al.

Ingår i Neuroscience, s. 540-551, 2009

• DOI för Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice

The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924

Jacobsson, Josefin A; Risérus, Ulf; Axelsson, Tomas; Lannfelt, Lars et al.

Ingår i BMC Medical Genetics, s. 131, 2009

• DOI för The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924

Further analysis of previously implicated linkage regions for Alzheimer’s disease in affected relative pairs

Blom, Elin Susanne; Giedraitis, Vilmantas; Arepalli, Sampath; Hamshere, Marian L. et al.

Ingår i BMC Medical Genetics, s. 122, 2009

• DOI för Further analysis of previously implicated linkage regions for Alzheimer’s disease in affected relative pairs

No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration

Skoglund, Lena; Ingvast, Sofie; Matsui, Toshifumi; Freeman, Stefanie et al.

Ingår i Dementia and Geriatric Cognitive Disorders, s. 471-475, 2009

• DOI för No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration

Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation

Skoglund, Lena; Brundin, RoseMarie; Olofsson, Tommie; Kalimo, Hannu et al.

Ingår i Neurogenetics, s. 27-34, 2009

• DOI för Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation

Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men

Giedraitis, Vilmantas; Kilander, Lena; Degerman-Gunnarsson, Malin; Sundelöf, Johan et al.

Ingår i Dementia and Geriatric Cognitive Disorders, s. 59-68, 2009

• DOI för Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men

Circulating immune complexes of A beta and IgM in plasma of patients with Alzheimer's disease

Marcello, Andrea; Wirths, Oliver; Schneider-Axmann, Thomas; Degerman-Gunnarsson, Malin et al.

Ingår i Journal of neural transmission, s. 913-920, 2009

• DOI för Circulating immune complexes of A beta and IgM in plasma of patients with Alzheimer's disease

Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice

Lord, Anna; Englund, Hillevi; Söderberg, Linda; Tucker, Stina et al.

Ingår i The FEBS Journal, s. 995-1006, 2009

• DOI för Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice

Oligomerization partially explains the lowering of Aβ42 in Alzheimer's disease cerebrospinal fluid

Englund, Hillevi; Degerman Gunnarsson, Malin; Brundin, RoseMarie; Hedlund, Marie et al.

Ingår i Neuro-degenerative diseases, s. 139-147, 2009

• DOI för Oligomerization partially explains the lowering of Aβ42 in Alzheimer's disease cerebrospinal fluid

A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice

Philipson, Ola; Hammarström, Per; Nilsson, K Peter R; Portelius, Erik et al.

Ingår i Neurobiology of Aging, s. 1393-1405, 2009

• DOI för A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice

Glucose metabolism and the risk of Alzheimer's disease and dementia: a population-based 12 year follow-up study in 71-year-old men

Rönnemaa, Elina; Zethelius, Björn; Sundelöf, Johan; Sundström, Johan et al.

Ingår i Diabetologia, s. 1504-1510, 2009

• DOI för Glucose metabolism and the risk of Alzheimer's disease and dementia: a population-based 12 year follow-up study in 71-year-old men

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

Lord, Anna; Gumucio, Astrid; Englund, Hillevi; Sehlin, Dag et al.

Ingår i Neurobiology of Disease, s. 425-434, 2009

• DOI för An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

Sällsynta mutationer leder till framtidens behandling

Ingelsson, Martin; Basun, Hans; Pettersson, Frida Ekholm; Kilander, Lena et al.

Ingår i Läkartidningen, s. 1396-1400, 2009

Systemic inflammation and the risk of Alzheimer's disease and dementia: a prospective population-based study

Sundelöf, Johan; Kilander, Lena; Helmersson, Johanna; Larsson, Anders et al.

Ingår i Journal of Alzheimer's Disease, s. 79-87, 2009

• DOI för Systemic inflammation and the risk of Alzheimer's disease and dementia: a prospective population-based study

Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study

Sundelöf, Johan; Kilander, Lena; Helmersson, Johanna; Larsson, Anders et al.

Ingår i Journal of Alzheimer's Disease, s. 71-78, 2009

• DOI för Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study

Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice

Philipson, Ola; Lannfelt, Lars; Nilsson, Lars N. G.

Ingår i FEBS Letters, s. 3021-3026, 2009

• DOI för Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice

Frontotemporal Dementia-amyotrophic Lateral Sclerosis Complex is Simulated by Neurodegeneration With Brain Iron Accumulation

Santillo, Alexander; Skoglund, Lena; Lindau, Maria; Eeg-Olofsson, Karin et al.

Ingår i Alzheimer Disease and Associated Disorders, s. 298-300, 2009

• DOI för Frontotemporal Dementia-amyotrophic Lateral Sclerosis Complex is Simulated by Neurodegeneration With Brain Iron Accumulation

A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease

Verwey, N. A.; van der Flier, W M; Blennow, K; Clark, C et al.

Ingår i Annals of Clinical Biochemistry, s. 235-240, 2009

• DOI för A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease

The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers

Näsström, Thomas; Wahlberg, Therese; Karlsson, Mikael; Nikolajeff, Fredrik et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 872-876, 2009

• DOI för The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers

Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype

Blom, Elin S.; Giedraitis, Vilmantas; Zetterberg, Henrik; Fukumoto, Hiroaki et al.

Ingår i Dementia and Geriatric Cognitive Disorders, s. 458-464, 2009

• DOI för Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype

Does APOE explain the linkage of Alzheimer’s disease to chromosome 19q13?

Blom, Elin Susanne; Holmans, Peter; Arepalli, Sampath; Adighibe, Omanma et al.

Ingår i American Journal of Medical Genetics Part B: Neuropsychiatric Genetics American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, s. 778-83, 2008

• DOI för Does APOE explain the linkage of Alzheimer’s disease to chromosome 19q13?

Serum cystatin C and the risk of Alzheimer disease in elderly men

Sundelöf, Johan; Ärnlöv, J.; Ingelsson, E.; Sundström, J. et al.

Ingår i Neurology, s. 1072-1079, 2008

• DOI för Serum cystatin C and the risk of Alzheimer disease in elderly men

Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

O'Callaghan, Paul; Sandwall, Elina; Li, Jin-Ping; Yu, Hong et al.

Ingår i Brain Pathology, s. 548-561, 2008

• DOI för Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

Plasma β Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men: A Prospective, Population-Based Cohort Study

Sundelöf, Johan; Giedraitis, Vilmantas; Irizarry, Michael C; Sundström, Johan et al.

Ingår i Archives of Neurology, s. 256-63, 2008

• DOI för Plasma β Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men: A Prospective, Population-Based Cohort Study

Safety, efficacy, and biomarker findings of PBT2 in targeting A beta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

Lannfelt, Lars; Blennow, Kaj; Zetterberg, Henrik; Batsman, Stellan et al.

Ingår i Lancet Neurology, s. 779-786, 2008

• DOI för Safety, efficacy, and biomarker findings of PBT2 in targeting A beta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study

Auro, K.; Kristiansson, K.; Zethelius, Björn; Berne, Christian et al.

Ingår i Diabetologia, s. 464-472, 2008

• DOI för USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study

Low prevalence of APP duplications in Swedish and Finnish patients with early onset Alzheimer's disease

Blom, Elin Susanne; Viswanathan, Jayashree; Kilander, Lena; Helisalmi, Seppo et al.

Ingår i European Journal of Human Genetics, s. 171-5, 2008

• DOI för Low prevalence of APP duplications in Swedish and Finnish patients with early onset Alzheimer's disease

The tau S305S mutation causes frontotemporal dementia with parkinsonism

Skoglund, Lena; Viitanen, Matti; Kalimo, Hannu; Lannfelt, Lars et al.

Ingår i European Journal of Neurology, s. 156-161, 2008

• DOI för The tau S305S mutation causes frontotemporal dementia with parkinsonism

No association between CALHM1 and Alzheimer's disease risk

Bertram, Lars; Schjeide, Brit-Maren M.; Hooli, Basavaraj; Mullin, Kristina et al.

Ingår i Cell, s. 993-994, 2008

• DOI för No association between CALHM1 and Alzheimer's disease risk

Impaired insulin secretion increases the risk of Alzheimer disease

Rönnemaa, E; Zethelius, B; Sundelöf, J; Sundström, J et al.

Ingår i Neurology, s. 1046-47, 2008

• DOI för Impaired insulin secretion increases the risk of Alzheimer disease

In vivo amyloid imaging with PET in frontotemporal dementia

Engler, Henry; Santillo, Alexander Frizell; Wang, Shu Xia; Lindau, Maria et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 100-106, 2008

• DOI för In vivo amyloid imaging with PET in frontotemporal dementia

Clinical and Neuropathological Features of the Arctic APP Gene Mutation Causing Early-Onset Alzheimer Disease

Basun, Hans; Bogdanovic, Nenad; Ingelsson, Martin; Almkvist, Ove et al.

Ingår i Archives of Neurology, s. 499-505, 2008

• DOI för Clinical and Neuropathological Features of the Arctic APP Gene Mutation Causing Early-Onset Alzheimer Disease

Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes

Nilsson, K. Peter R.; Åslund, Andreas; Berg, Ina; Nyström, Sofie et al.

Ingår i ACS Chemical Biology, s. 553-560, 2007

• DOI för Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes

Sensitive ELISA detection of amyloid-β protofibrils in biological samples

Englund, Hillevi; Sehlin, Dag; Johansson, Ann-Sofi; Nilsson, Lars N.G. et al.

Ingår i Journal of Neurochemistry, s. 334-345, 2007

• DOI för Sensitive ELISA detection of amyloid-β protofibrils in biological samples

Attenuated amyloid-β aggregation and neurotoxicity owing to methionine oxidation

Johansson, Ann-Sofi; Bergquist, Jonas; Volbracht, Christiane; Päiviö, Anna et al.

Ingår i NeuroReport, s. 559-563, 2007

Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Aβ levels in cellular models of Alzheimer's disease

Sahlin, Charlotte; Ekholm Pettersson, Frida; Nilsson, Lars; Lannfelt, Lars et al.

Ingår i European Journal of Neuroscience, s. 882-889, 2007

• DOI för Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Aβ levels in cellular models of Alzheimer's disease

Docosahexaenoic acid stabilizes soluble amyloid-β protofibrils and sustains amyloid-β induced neurotoxicity in vitro

Johansson, Ann-Sofi; Garlind, Anita; Berglind-Dehlin, Fredrik; Karlsson, Göran et al.

Ingår i The FEBS Journal, s. 990-1000, 2007

• DOI för Docosahexaenoic acid stabilizes soluble amyloid-β protofibrils and sustains amyloid-β induced neurotoxicity in vitro

Apolipoprotein E epsilon 4 genotype is independently associated with increased intima-media thickness in a recessive pattern

Wohlin, Martin; Sundström, Johan; Lannfelt, Lars; Axelsson, Tomas et al.

Ingår i Lipids, s. 451-456, 2007

• DOI för Apolipoprotein E epsilon 4 genotype is independently associated with increased intima-media thickness in a recessive pattern

Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity

Warensjö, Eva; Ingelsson, Erik; Lundmark, Per; Lannfelt, Lars et al.

Ingår i Obesity, s. 1732-1740, 2007

• DOI för Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity

Longitudinal stability of CSF biomarkers in Alzheimer's disease

Blennow, Kaj; Zetterberg, Henrik; Minthon, Lennart; Lannfelt, Lars et al.

Ingår i Neuroscience Letters, s. 18-22, 2007

• DOI för Longitudinal stability of CSF biomarkers in Alzheimer's disease

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

Sahlin, Charlotte; Lord, Anna; Magnusson, Kristina; Englund, Hillevi et al.

Ingår i Journal of Neurochemistry, s. 854-862, 2007

• DOI för The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

Underskatta inte värdet av transgena djurmodeller av Alzheimers sjukdom

Nilsson, Lars; Lannfelt, Lars; Basun, Hans; Nordberg, Agneta et al.

Ingår i Läkartidningen, s. 798-800, 2007

Increase in beta-Amyloid Levels in Cerebrospinal Fluid of Children with Down Syndrome

Englund, Hillevi; Annerén, Göran; Gustafsson, Jan; Wester, Ulrika et al.

Ingår i Dementia and Geriatric Cognitive Disorders, s. 369-374, 2007

• DOI för Increase in beta-Amyloid Levels in Cerebrospinal Fluid of Children with Down Syndrome

The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease

Giedraitis, Vilmantas; Sundelöf, Johan; Irizarry, Michael C; Gårevik, Nina et al.

Ingår i Neuroscience Letters, s. 127-131, 2007

• DOI för The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease

Reduction of Phosphorylated Tau during Memantine Treatment of Alzheimer's Disease

Degerman Gunnarsson, Malin; Kilander, Lena; Basun, Hans; Lannfelt, Lars

Ingår i Dementia and Geriatric Cognitive Disorders, s. 247-252, 2007

• DOI för Reduction of Phosphorylated Tau during Memantine Treatment of Alzheimer's Disease

Association study of cholesterol-related genes in Alzheimer's disease

Wollmer, M Axel.; Sleegers, Kristel; Ingelsson, Martin; Zekanowski, Cezary et al.

Ingår i Neurogenetics, s. 179-188, 2007

• DOI för Association study of cholesterol-related genes in Alzheimer's disease

New Alzheimer's disease locus on chromosome 8

Giedraitis, Vilmantas; Hedlund, M.; Skoglund, Lena; Blom, Elin et al.

Ingår i Journal of Medical Genetics, s. 931-935, 2006

• DOI för New Alzheimer's disease locus on chromosome 8

Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation.

Murphy, Eric J; Huang, Hsueh-Meei; Cowburn, Richard F; Lannfelt, Lars et al.

Ingår i Brain Res Bull, s. 79-85, 2006

The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice.

Lord, Anna; Kalimo, Hannu; Eckman, Chris; Zhang, Xiao-Qun et al.

Ingår i Neurobiol Aging, s. 67-77, 2006

Physiochemical characterization of the Alzheimer's disease-related peptides A beta 1-42Arctic and A beta 1-42wt

Johansson, Ann-Sofi; Berglind-Dehlin, Fredrik; Karlsson, Göran; Edwards, Katarina et al.

Ingår i FEBS Journal, s. 2618-30, 2006

• DOI för Physiochemical characterization of the Alzheimer's disease-related peptides A beta 1-42Arctic and A beta 1-42wt

Identification of novel biomarker candidates by differential peptidomics analysis of cerebrospinal fluid in Alzheimer's disease.

Selle, Hartmut; Lamerz, Jens; Buerger, Katharina; Dessauer, Andreas et al.

Ingår i Comb Chem High Throughput Screen, s. 801-6, 2005

Konformationsförändrade proteiner orsakar neurodegenerativa sjukdomar

Ingelsson, Martin; Nilsson, Lars; Basun, Hans; Aquilonius, Sten-Magnus et al.

Ingår i Läkartidningen, s. 3542-3551, 2005

Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.

Flood, F; Murphy, S; Cowburn, R F; Lannfelt, L et al.

Ingår i Biochem J, s. 545-50, 2005

Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay.

Stenh, Charlotte; Englund, Hillevi; Lord, Anna; Johansson, Ann-Sofi et al.

Ingår i Ann Neurol, s. 147-50, 2005

Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia.

Wiltfang, J; Lewczuk, P; Riederer, P; Grunblatt, E et al.

Ingår i World J Biol Psychiatry, s. 69-84, 2005

Clinical and molecular aspects of frontotemporal dementia.

Froelich-Fabre, Susanne; Skoglund, Lena; Ostojic, Jovanka; Kilander, Lena et al.

Ingår i Neurodegener Dis, s. 218-24, 2004

No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found.

Johnson, J; Ostojic, J; Lannfelt, L; Glaser, A et al.

Ingår i Neurosci Lett, s. 99-101, 2004

Unique physicochemical profile of beta-amyloid peptide variant Abeta1-40E22G protofibrils: conceivable neuropathogen in arctic mutant carriers.

Päiviö, A; Jarvet, J; Gräslund, A; Lannfelt, L et al.

Ingår i J Mol Biol, s. 145-59, 2004

Familial presenile dementia with bitemporal atrophy.

Passant, U; Ostojic, J; Froelich Fabre, S; Gustafson, L et al.

Ingår i Dement Geriatr Cogn Disord, s. 287-92, 2004

The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy.

Ostojic, J; Elfgren, C; Passant, U; Nilsson, K et al.

Ingår i Dement Geriatr Cogn Disord, s. 298-301, 2004

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid-β fibril formation

Pagnon de la Vega, María; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Ingår i Science Translational Medicine

The Amyloid-beta Pathway in Alzheimer's Disease

Hampel, Harald; Hardy, John; Blennow, Kaj; Chen, Christopher et al.

Ingår i Molecular Psychiatry, s. 5481-5503, 2021

• DOI för The Amyloid-beta Pathway in Alzheimer's Disease
• Ladda ner fulltext (pdf) av The Amyloid-beta Pathway in Alzheimer's Disease

Immunotherapy targeting alpha-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders

Lindström, Veronica; Ihse, Elisabet; Fagerqvist, Therese; Bergström, Joakim et al.

Ingår i Immunotherapy, s. 141-153, 2014

• DOI för Immunotherapy targeting alpha-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders

Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease

Lannfelt, Lars; Moller, Christer; Basun, Hans; Osswald, Gunilla et al.

Ingår i ALZHEIMERS RES THER, s. 16, 2014

• DOI för Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease
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Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease

Lannfelt, Lars; Ekholm Pettersson, Frida; Nilsson, Lars N. G.

Ingår i Nutrition reviews, 2010

• DOI för Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease

Animal models of amyloid-β-related pathologies in Alzheimer’s disease

Philipson, Ola; Lord, Anna; Gumucio, Astrid; O'Callaghan, Paul et al.

Ingår i The FEBS Journal, s. 1389-1409, 2010

• DOI för Animal models of amyloid-β-related pathologies in Alzheimer’s disease

Consensus Paper of the WFSBP Task Force on Biological Markers of Dementia: The role of CSF and blood analysis in the early and differential diagnosis of dementia

Wiltfang, J.; Lewczuk, P.; Riederer, P.; Gruenblatt, E. et al.

Ingår i Revista de Psiquiatria Clinica, s. 1-16, 2009

Journal of Labelled Compounds and Pharmaceuticals: Neurosciences session

Rokka, Johanna; Fang, Xiaotian T.; Hultqvist, Greta; Faresjö, Rebecca et al.

Ingår i ISRS 2019, 2019

• DOI för Journal of Labelled Compounds and Pharmaceuticals: Neurosciences session

Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo

Wahlberg, Therese; Näsström, Thomas; Sahlin, Charlotte; Ingvast, Sofie et al.

2010

• DOI för Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo

Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo

Ingelsson, Martin; Wahlberg, Therese; Näsström, Thomas; Sahlin, Charlotte et al.

2010

Details of neuropathology in Arctic Alzheimer's disease

Kalimo, H.; Bogdanovic, N.; Callaghan, Paul O.; Bird, T. D. et al.

Ingår i Abstracts of the XVIIth International Congress of Neuropathology (ICN 2010), Salzburg, Austria, 11-15 September 2010, s. 22-23, 2010

• DOI för Details of neuropathology in Arctic Alzheimer's disease

Morphological and functional differences of aldehyde-induced alpha-synuclein oligomers

Näsström, Thomas; Wahlberg, Therese; Barbu, Mikael; Silva, V. et al.

Ingår i Amyloid - Journal of Protein Folding Disorders, s. 93-94, 2010

Effects of lipid peroxidation metabolites on alpha-synuclein aggregation

Bergström, Joakim; Näsström, Thomas; Wahlberg, Therese; Karlsson, Mikael et al.

2009

GPR162 is expressed in the hypothalamus and is involved in food intake related behaviour

Sreedharan, Smitha; Carlini, Valeria P; Jacobsson, Josefin A; Olszewski, Pawel K et al.

2011

The Uppsala APP mutation promotes wildtype Aβ aggregation and deposition in vivo

Pagnon de la Vega, María; Ge, Junyue; Giedraitis, Vilmantas; Syvänen, Stina et al.

Transgenic mice harboring the Uppsala APP mutation display altered APP processing and accelerated Aβ42 pathology with distinct structural features

Pagnon de la Vega, María; Syvänen, Stina; Hooley, Monique; Giedraitis, Vilmantas et al.