Dag Sehlin
Senior Lecturer/Associate Professor at Department of Public Health and Caring Sciences; Molecular Geriatrics / Rudbeck laboratory
- Telephone:
- +46 18 471 34 05
- Mobile phone:
- +46 73 469 74 52
- E-mail:
- dag.sehlin@uu.se
- Visiting address:
- Dag Hammarskjölds väg 20
- Postal address:
- Rudbecklaboratoriet
751 85 Uppsala
Short presentation
Associate professor in Neurobiology
Here is a description of my research.
Biography
Dag Sehlin is Associate Professor of Neurobiology at Uppsala University. His research is focused on understanding the molecular mechanisms behind Alzheimer's disease and using this knowledge for development of novel therapeutic and diagnostic applications. His group has generated antibodies that bind specifically to different forms of amyloid-beta, to be used for both therapeutic and diagnostic purposes. By engineering the antibodies into a bispecific format that takes advantage of a ‘Molecular Trojan horse’ strategy to enter the brain more efficiently, the group has pioneered antibody-based PET imaging of brain targets.
Dag Sehlin received his PhD in 2010 after a joint academic-industrial project at Uppsala University, BioArctic AB and Mabtech AB that resulted in development of the amyloid-beta protofibril specific antibody lecanemab, which was recently approved for treatment of Alzheimer's disease. After a post doc at Uppsala University he focused on development of strategies to deliver protein drugs into the brain, for which he received prizes from the Swedish Lundbeck foundation and the Swedish Alzheimer foundation. He was appointed Associate Professor (docent) in 2018 and Senior Lecturer in 2024. Dag has authored 75 scientific articles, has an h-index of 29 and holds patents describing antibody development and engineering for increased brain penetration.

Publications
Selection of publications
Part of mAbs, 2024
- DOI for Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
- Download full text (pdf) of Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
Part of Acta neuropathologica communications, 2024
- DOI for Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
- Download full text (pdf) of Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
Part of Alzheimer's Research & Therapy, 2023
- DOI for Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
- Download full text (pdf) of Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
Part of Journal of Nuclear Medicine, p. 302-309, 2022
- DOI for 11C-PiB and 124I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
- Download full text (pdf) of 11C-PiB and 124I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
Part of Science Translational Medicine, 2021
Part of Translational Neurodegeneration, 2020
- DOI for SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease
- Download full text (pdf) of SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease
Engineered antibodies: new possibilities for brain PET?
Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 2848-2858, 2019
- DOI for Engineered antibodies: new possibilities for brain PET?
- Download full text (pdf) of Engineered antibodies: new possibilities for brain PET?
Part of Alzheimer's Research & Therapy, 2018
- DOI for Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
- Download full text (pdf) of Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
Part of Theranostics, p. 308-318, 2017
- DOI for Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
- Download full text (pdf) of Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
Part of Nature Communications, 2016
- DOI for Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
- Download full text (pdf) of Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
Sensitive ELISA detection of amyloid-β protofibrils in biological samples
Part of Journal of Neurochemistry, p. 334-345, 2007
Recent publications
Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
Part of Journal of Neuroinflammation, 2025
- DOI for Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
- Download full text (pdf) of Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
Part of Analytical Chemistry, p. 1338-1346, 2025
- DOI for Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
- Download full text (pdf) of Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
Part of Fluids and Barriers of the CNS, 2025
- DOI for The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
- Download full text (pdf) of The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
Part of Neurotherapeutics, 2025
- DOI for A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
- Download full text (pdf) of A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
Part of Neurotherapeutics, 2025
- DOI for Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
- Download full text (pdf) of Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
All publications
Articles in journal
Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
Part of Journal of Neuroinflammation, 2025
- DOI for Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
- Download full text (pdf) of Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
Part of Analytical Chemistry, p. 1338-1346, 2025
- DOI for Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
- Download full text (pdf) of Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
Part of Fluids and Barriers of the CNS, 2025
- DOI for The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
- Download full text (pdf) of The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
Part of Neurotherapeutics, 2025
- DOI for A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
- Download full text (pdf) of A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
Part of Neurotherapeutics, 2025
- DOI for Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
- Download full text (pdf) of Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
Part of Journal of Biological Chemistry, 2025
- DOI for Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
- Download full text (pdf) of Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
Part of Scientific Reports, 2024
- DOI for A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
- Download full text (pdf) of A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
Part of mAbs, 2024
- DOI for Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
- Download full text (pdf) of Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
Part of Analytical Biochemistry, 2024
- DOI for Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
- Download full text (pdf) of Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
Antibody engagement with amyloid‐beta does not inhibit [11C]PiB binding for PET imaging
Part of Journal of Neurochemistry, p. 2601-2610, 2024
- DOI for Antibody engagement with amyloid‐beta does not inhibit [11C]PiB binding for PET imaging
- Download full text (pdf) of Antibody engagement with amyloid‐beta does not inhibit [11C]PiB binding for PET imaging
Part of mAbs, 2024
- DOI for Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
- Download full text (pdf) of Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
Part of Upsala Journal of Medical Sciences, 2024
- DOI for Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
- Download full text (pdf) of Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Part of Molecular and Cellular Neuroscience, 2024
- DOI for Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
- Download full text (pdf) of Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
Part of EJNMMI Radiopharmacy and Chemistry, 2024
- DOI for Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
- Download full text (pdf) of Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
Part of Acta neuropathologica communications, 2024
- DOI for Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
- Download full text (pdf) of Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
Part of Frontiers in Nuclear Medicine, 2023
- DOI for Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
- Download full text (pdf) of Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
Synaptic density in aging mice measured by [18F]SynVesT-1 PET
Part of NeuroImage, 2023
- DOI for Synaptic density in aging mice measured by [18F]SynVesT-1 PET
- Download full text (pdf) of Synaptic density in aging mice measured by [18F]SynVesT-1 PET
Part of Nature Neuroscience, p. 2073-2080, 2023
- DOI for Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease
- Download full text (pdf) of Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease
Part of Alzheimer's Research & Therapy, 2023
- DOI for Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
- Download full text (pdf) of Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
Part of Fluids and Barriers of the CNS, 2023
- DOI for Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
- Download full text (pdf) of Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
Part of Frontiers in Nuclear Medicine, 2022
- DOI for The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
- Download full text (pdf) of The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins
Part of ChemBioChem, 2022
- DOI for Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins
- Download full text (pdf) of Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins
Part of Fluids and Barriers of the CNS, 2022
- DOI for Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis
- Download full text (pdf) of Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis
Part of NEUROTHERAPEUTICS, p. 1588-1602, 2022
- DOI for A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
- Download full text (pdf) of A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies
Part of Pharmaceutical research, p. 1509-1521, 2022
- DOI for Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies
- Download full text (pdf) of Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies
Part of Pharmaceutics, 2022
- DOI for Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
- Download full text (pdf) of Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
In vivo imaging of alpha-synuclein with antibody-based PET
Part of Neuropharmacology, 2022
- DOI for In vivo imaging of alpha-synuclein with antibody-based PET
- Download full text (pdf) of In vivo imaging of alpha-synuclein with antibody-based PET
Part of Translational Neurodegeneration, 2022
- DOI for ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein
- Download full text (pdf) of ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein
Part of Molecular Pharmaceutics, p. 4111-4122, 2022
- DOI for Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging
- Download full text (pdf) of Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging
Passive and receptor mediated brain delivery of an anti-GFAP nanobody
Part of Nuclear Medicine and Biology, p. 128-134, 2022
- DOI for Passive and receptor mediated brain delivery of an anti-GFAP nanobody
- Download full text (pdf) of Passive and receptor mediated brain delivery of an anti-GFAP nanobody
Part of Alzheimer's Research & Therapy, 2022
- DOI for Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
- Download full text (pdf) of Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?
Part of Pharmaceuticals, 2022
- DOI for Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?
- Download full text (pdf) of Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?
Part of Journal of Nuclear Medicine, p. 302-309, 2022
- DOI for 11C-PiB and 124I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
- Download full text (pdf) of 11C-PiB and 124I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
Part of Translational Neurodegeneration, 2021
- DOI for Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
- Download full text (pdf) of Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
Part of Theranostics, p. 789-804, 2021
- DOI for Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
- Download full text (pdf) of Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
Part of Fluids and Barriers of the CNS, 2021
- DOI for Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
- Download full text (pdf) of Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
Part of Science Translational Medicine, 2021
Part of NeuroImage, 2021
- DOI for In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease
- Download full text (pdf) of In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease
Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease
Part of Molecular Imaging and Biology, p. 665-675, 2021
- DOI for Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease
- Download full text (pdf) of Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease
Part of Scientific Reports, 2020
- DOI for Extracellular vesicles from amyloid-beta exposed cell cultures induce severe dysfunction in cortical neurons
- Download full text (pdf) of Extracellular vesicles from amyloid-beta exposed cell cultures induce severe dysfunction in cortical neurons
Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
Part of ACS Chemical Neuroscience, p. 4460-4468, 2020
- DOI for Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
- Download full text (pdf) of Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
Part of Translational Neurodegeneration, 2020
- DOI for SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease
- Download full text (pdf) of SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease
Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
Part of The FASEB Journal, p. 13272-13283, 2020
- DOI for Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
- Download full text (pdf) of Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
Part of Journal of Neurochemistry, p. 602-616, 2020
Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus
Part of Journal of Neurosurgery, p. 121-129, 2019
Part of Scientific Reports, 2019
- DOI for Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
- Download full text (pdf) of Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease
Part of Journal of Alzheimer's Disease, p. 161-180, 2019
- DOI for Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease
- Download full text (pdf) of Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease
Part of Journal of Biological Chemistry, p. 6719-6732, 2019
- DOI for Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
- Download full text (pdf) of Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain
Part of NeuroImage, p. 881-888, 2019
Part of Journal of Neuroinflammation, 2018
- DOI for The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death
- Download full text (pdf) of The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death
Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells
Part of Cellular and molecular neurobiology, p. 1539-1550, 2018
- DOI for Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells
- Download full text (pdf) of Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells
Part of Neuropharmacology, p. 1-9, 2018
- DOI for Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
- Download full text (pdf) of Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
Part of Journal of Nuclear Medicine, p. 1885-1891, 2018
- DOI for Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
- Download full text (pdf) of Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
Part of Alzheimer's Research & Therapy, 2018
- DOI for Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
- Download full text (pdf) of Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease
Part of Molecular Imaging and Biology, p. 605-614, 2018
- DOI for Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease
- Download full text (pdf) of Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease
Part of Biological Procedures Online, 2017
- DOI for Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
- Download full text (pdf) of Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
Part of Journal of Cerebral Blood Flow and Metabolism, p. 415-416, 2017
Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
Part of Theranostics, p. 308-318, 2017
- DOI for Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
- Download full text (pdf) of Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
Part of ACS Chemical Neuroscience, p. 347-355, 2017
- DOI for Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry
- Download full text (pdf) of Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry
Part of Scientific Reports, 2017
- DOI for Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-beta
- Download full text (pdf) of Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-beta
Part of Meeting abstract, 2017
Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')2 fragment
Part of Biochemical and Biophysical Research Communications - BBRC, p. 120-125, 2017
- DOI for Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')2 fragment
- Download full text (pdf) of Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')2 fragment
Part of Neuropharmacology, p. 293-300, 2017
Part of NeuroImage, p. 55-63, 2017
- DOI for A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
- Download full text (pdf) of A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
Part of Nature Communications, 2016
- DOI for Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
- Download full text (pdf) of Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
Part of Molecular Neurodegeneration, 2016
Part of Molecular Neurodegeneration, 2016
- DOI for Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
- Download full text (pdf) of Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
Part of Journal of Alzheimer's Disease, p. 63-72, 2015
- DOI for Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease
- Download full text (pdf) of Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease
Part of Amyloid, p. 76-87, 2014
Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease
Part of PLOS ONE, 2014
- DOI for Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease
- Download full text (pdf) of Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease
Part of Journal of Alzheimer's Disease, p. 29-40, 2013
Part of PLOS ONE, 2012
Part of Neurodegenerative Diseases, p. 117-123, 2011
Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease
Part of BMC Neuroscience, p. 124, 2010
Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs
Part of Journal of Alzheimer's Disease, p. 1295-1301, 2010
Part of Neurobiology of Disease, p. 425-434, 2009
Sensitive ELISA detection of amyloid-β protofibrils in biological samples
Part of Journal of Neurochemistry, p. 334-345, 2007
Part of Science Translational Medicine
Articles, review/survey
PET Imaging in Preclinical Anti-Aβ Drug Development
Part of Pharmaceutical research, p. 1481-1496, 2022
- DOI for PET Imaging in Preclinical Anti-Aβ Drug Development
- Download full text (pdf) of PET Imaging in Preclinical Anti-Aβ Drug Development
Engineered antibodies: new possibilities for brain PET?
Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 2848-2858, 2019
- DOI for Engineered antibodies: new possibilities for brain PET?
- Download full text (pdf) of Engineered antibodies: new possibilities for brain PET?
Part of ALZHEIMERS RES THER, p. 16, 2014
- DOI for Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease
- Download full text (pdf) of Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease
Comprehensive doctoral thesis
Manuscripts (preprints)
The Uppsala APP mutation promotes wildtype Aβ aggregation and deposition in vivo
Single domain antibody conjugated to Aβ-binding scFv penetrates BBB via TfR to interact with Aβ
Synaptic density in aging mice measured by [18F]SynVesT-1 PET
[11C]PiB binding after treatment with an amyloid-beta antibody
Evaluation of valency effects on TfR-mediated brain delivery in vivo