Dag Sehlin

Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Schlein, Eva; Andersson, Ken G.; Dallas, Tiffany; Syvänen, Stina et al.

Ingår i mAbs, 2024

• DOI för Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
• Ladda ner fulltext (pdf) av Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
• Ladda ner fulltext (pdf) av Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Alzheimer's Research & Therapy, 2023

• DOI för Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
• Ladda ner fulltext (pdf) av Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Meier, Silvio R.; Sehlin, Dag; Roshanbin, Sahar; Lim Falk, Victoria et al.

Ingår i Journal of Nuclear Medicine, s. 302-309, 2022

• DOI för ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
• Ladda ner fulltext (pdf) av ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Ingår i Science Translational Medicine, 2021

• DOI för The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Syvänen, Stina; O'Callaghan, Paul; Sehlin, Dag

Ingår i Translational Neurodegeneration, 2020

• DOI för SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease
• Ladda ner fulltext (pdf) av SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease

Engineered antibodies: new possibilities for brain PET?

Sehlin, Dag; Syvänen, Stina; Ballanger, Benedicte; Barthel, Henryk et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 2848-2858, 2019

• DOI för Engineered antibodies: new possibilities for brain PET?
• Ladda ner fulltext (pdf) av Engineered antibodies: new possibilities for brain PET?

Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Syvänen, Stina; Hultqvist, Greta; Gustavsson, Tobias; Gumucio, Astrid et al.

Ingår i Alzheimer's Research & Therapy, 2018

• DOI för Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
• Ladda ner fulltext (pdf) av Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars et al.

Ingår i Theranostics, s. 308-318, 2017

• DOI för Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
• Ladda ner fulltext (pdf) av Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Sehlin, Dag; Fang, Xiaotian T.; Cato, Linda; Antoni, Gunnar et al.

Ingår i Nature Communications, 2016

• DOI för Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
• Ladda ner fulltext (pdf) av Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Sensitive ELISA detection of amyloid-β protofibrils in biological samples

Englund, Hillevi; Sehlin, Dag; Johansson, Ann-Sofi; Nilsson, Lars N.G. et al.

Ingår i Journal of Neurochemistry, s. 334-345, 2007

• DOI för Sensitive ELISA detection of amyloid-β protofibrils in biological samples

Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Dahlén, Amelia; Roshanbin, Sahar; Bucher, Nadja M.; Sehlin, Dag et al.

Ingår i Experimental Neurology, 2026

• DOI för Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies
• Ladda ner fulltext (pdf) av Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Dahlén, Amelia; Roshanbin, Sahar; Aguilar, Ximena; Bucher, Nadja et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 4320-4333, 2025

• DOI för PET imaging of TREM2 in amyloid-beta induced neuroinflammation
• Ladda ner fulltext (pdf) av PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Lopes van den Broek, Sara; Eriksson, Jonas; Yang, Qiaojun; Bucher, Nadja M. et al.

Ingår i Translational Neurodegeneration, 2025

• DOI för Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine
• Ladda ner fulltext (pdf) av Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Metzendorf, Nicole G.; Sehlin, Dag; Hultqvist, Greta

Ingår i Frontiers in Neuroscience, 2025

• DOI för Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
• Ladda ner fulltext (pdf) av Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Zielinski, Mara; Peralta Reyes, Fernanda S.; Gremer, Lothar; Sommerhage, Simon et al.

Ingår i Acta neuropathologica communications, 2025

• DOI för Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)
• Ladda ner fulltext (pdf) av Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Dahlén, Amelia; Roshanbin, Sahar; Bucher, Nadja M.; Sehlin, Dag et al.

Ingår i Experimental Neurology, 2026

• DOI för Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies
• Ladda ner fulltext (pdf) av Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Dahlén, Amelia; Roshanbin, Sahar; Aguilar, Ximena; Bucher, Nadja et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 4320-4333, 2025

• DOI för PET imaging of TREM2 in amyloid-beta induced neuroinflammation
• Ladda ner fulltext (pdf) av PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Lopes van den Broek, Sara; Eriksson, Jonas; Yang, Qiaojun; Bucher, Nadja M. et al.

Ingår i Translational Neurodegeneration, 2025

• DOI för Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine
• Ladda ner fulltext (pdf) av Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Metzendorf, Nicole G.; Sehlin, Dag; Hultqvist, Greta

Ingår i Frontiers in Neuroscience, 2025

• DOI för Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
• Ladda ner fulltext (pdf) av Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Zielinski, Mara; Peralta Reyes, Fernanda S.; Gremer, Lothar; Sommerhage, Simon et al.

Ingår i Acta neuropathologica communications, 2025

• DOI för Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)
• Ladda ner fulltext (pdf) av Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

Sehlin, Dag; Hultqvist, Greta; Michno, Wojciech; Aguilar, Ximena et al.

Ingår i The Journal of Prevention of Alzheimer's Disease, 2025

• DOI för Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease
• Ladda ner fulltext (pdf) av Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease

Sehlin, Dag; Aguilar, Ximena; Cortes-Canteli, Marta; Syvänen, Stina et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease
• Ladda ner fulltext (pdf) av Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease

Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology

Schlein, Eva; Lopes van den Broek, Sara; Dallas, Tiffany; Andersson, Ken G. et al.

Ingår i ACS Pharmacology & Translational Science, s. 2804-2813, 2025

• DOI för Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology
• Ladda ner fulltext (pdf) av Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology

High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

Bonvicini, Gillian; Singh, Sunitha; Sandersjoo, Lisa; Dallas, Tiffany et al.

Ingår i Fluids and Barriers of the CNS, 2025

• DOI för High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose
• Ladda ner fulltext (pdf) av High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET

Gonzalez-Arjona, Mario; Cusso, Lorena; Alcala, Luis; Gonzalez, Maria Isabel et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET
• Ladda ner fulltext (pdf) av Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET

Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

de la Rosa, Andrés; Metzendorf, Nicole G.; Efverström, Jonathan; Godec, Ana et al.

Ingår i Neurotherapeutics, 2025

• DOI för Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
• Ladda ner fulltext (pdf) av Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology

Sehlin, Dag; Roshanbin, Sahar; Zachrisson, Olof; Ingelsson, Martin et al.

Ingår i Neurotherapeutics, 2025

• DOI för A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
• Ladda ner fulltext (pdf) av A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology

Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery

Beretta, Chiara; Dakhel, Abdulkhalek; Eltom, Khalid; Rosqvist, Fredrik et al.

Ingår i Journal of Neuroinflammation, 2025

• DOI för Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
• Ladda ner fulltext (pdf) av Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery

Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

Lee, Yea-Rin; Kaya, Ibrahim; Wik, Elin; Baijnath, Sooraj et al.

Ingår i Analytical Chemistry, s. 1338-1346, 2025

• DOI för Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
• Ladda ner fulltext (pdf) av Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

Bonvicini, Gillian; Singh, Sunitha; Sandersjoo, Lisa; Sehlin, Dag et al.

Ingår i Fluids and Barriers of the CNS, 2025

• DOI för The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
• Ladda ner fulltext (pdf) av The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

Klingstedt, Therése; Shirani, Hamid; Parvin, Farjana; Nyström, Sofie et al.

Ingår i Journal of Biological Chemistry, 2025

• DOI för Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
• Ladda ner fulltext (pdf) av Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Petersen, Inga; Morrison, Jamie I.; Petrovic, Alex; Babic, Neira et al.

Ingår i Scientific Reports, 2024

• DOI för A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
• Ladda ner fulltext (pdf) av A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Schlein, Eva; Andersson, Ken G.; Dallas, Tiffany; Syvänen, Stina et al.

Ingår i mAbs, 2024

• DOI för Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
• Ladda ner fulltext (pdf) av Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity

Bonvicini, Gillian; Singh, Sunitha; Nygren, Patrik; Xiong, Mengfei et al.

Ingår i Analytical Biochemistry, 2024

• DOI för Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
• Ladda ner fulltext (pdf) av Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity

Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging

Xiong, Mengfei; Dahlén, Amelia; Roshanbin, Sahar; Wik, Elin et al.

Ingår i Journal of Neurochemistry, s. 2601-2610, 2024

• DOI för Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging
• Ladda ner fulltext (pdf) av Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging

Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β

Faresjö, Rebecca; Sjöström, Elisabet O.; Dallas, Tiffany; Berglund, Magnus M. et al.

Ingår i mAbs, 2024

• DOI för Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
• Ladda ner fulltext (pdf) av Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β

Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging

Gustavsson, Tobias; Herth, Matthias M.; Sehlin, Dag; Syvänen, Stina

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
• Ladda ner fulltext (pdf) av Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging

Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms

Beretta, Chiara; Svensson, Elina; Dakhel, Abdulkhalek; Zyśk, Marlena et al.

Ingår i Molecular and Cellular Neuroscience, 2024

• DOI för Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
• Ladda ner fulltext (pdf) av Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms

Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Schlein, Eva; Rokka, Johanna; Odell, Luke R.; Lopes van den Broek, Sara et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
• Ladda ner fulltext (pdf) av Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
• Ladda ner fulltext (pdf) av Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau

Banka, Vinay; Kelleher, Andrew; Sehlin, Dag; Hultqvist, Greta et al.

Ingår i Frontiers in Nuclear Medicine, 2023

• DOI för Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
• Ladda ner fulltext (pdf) av Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau

Synaptic density in aging mice measured by [18F]SynVesT-1 PET

Xiong, Mengfei; Roshanbin, Sahar; Sehlin, Dag; Hansen, Hanne D. et al.

Ingår i NeuroImage, 2023

• DOI för Synaptic density in aging mice measured by [18F]SynVesT-1 PET
• Ladda ner fulltext (pdf) av Synaptic density in aging mice measured by [18F]SynVesT-1 PET

Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease

Zielinski, Mara; Peralta Reyes, Fernanda S; Gremer, Lothar; Schemmert, Sarah et al.

Ingår i Nature Neuroscience, s. 2073-2080, 2023

• DOI för Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease
• Ladda ner fulltext (pdf) av Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Alzheimer's Research & Therapy, 2023

• DOI för Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
• Ladda ner fulltext (pdf) av Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Faresjö, Rebecca; Sehlin, Dag; Syvänen, Stina

Ingår i Fluids and Barriers of the CNS, 2023

• DOI för Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
• Ladda ner fulltext (pdf) av Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Ingår i Neurotherapeutics, s. 1588-1602, 2022

• DOI för A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
• Ladda ner fulltext (pdf) av A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

van den Broek, Sara Lopes; Sehlin, Dag; Andersen, Jens V.; Aldana, Blanca I. et al.

Ingår i Frontiers in Nuclear Medicine, 2022

• DOI för The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
• Ladda ner fulltext (pdf) av The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

Faresjö, Rebecca; Lindberg, Hanna; Stahl, Stefan; Lofblom, John et al.

Ingår i Pharmaceutical research, s. 1509-1521, 2022

• DOI för Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies
• Ladda ner fulltext (pdf) av Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins

Bidesi, Natasha Shalina Radjani; Battisti, Umberto Maria; van de Broek, Sara Lopes; Shalgunov, Vladimir et al.

Ingår i ChemBioChem, 2022

• DOI för Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins
• Ladda ner fulltext (pdf) av Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins

Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Julku, Ulrika; Xiong, Mengfei; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Fluids and Barriers of the CNS, 2022

• DOI för Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis
• Ladda ner fulltext (pdf) av Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas et al.

Ingår i Pharmaceutics, 2022

• DOI för Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
• Ladda ner fulltext (pdf) av Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

In vivo imaging of alpha-synuclein with antibody-based PET

Roshanbin, Sahar; Xiong, Mengfei; Hultqvist, Greta; Soderberg, Linda et al.

Ingår i Neuropharmacology, 2022

• DOI för In vivo imaging of alpha-synuclein with antibody-based PET
• Ladda ner fulltext (pdf) av In vivo imaging of alpha-synuclein with antibody-based PET

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein

Bonvicini, Gillian; Syvänen, Stina; Andersson, Ken G. G.; Haaparanta-Solin, Merja et al.

Ingår i Translational Neurodegeneration, 2022

• DOI för ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein
• Ladda ner fulltext (pdf) av ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Schlein, Eva; Syvänen, Stina; Rokka, Johanna; Gustavsson, Tobias et al.

Ingår i Molecular Pharmaceutics, s. 4111-4122, 2022

• DOI för Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging
• Ladda ner fulltext (pdf) av Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Passive and receptor mediated brain delivery of an anti-GFAP nanobody

Meier, Silvio R.; Sehlin, Dag; Syvänen, Stina

Ingår i Nuclear Medicine and Biology, s. 128-134, 2022

• DOI för Passive and receptor mediated brain delivery of an anti-GFAP nanobody
• Ladda ner fulltext (pdf) av Passive and receptor mediated brain delivery of an anti-GFAP nanobody

Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura et al.

Ingår i Alzheimer's Research & Therapy, 2022

• DOI för Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
• Ladda ner fulltext (pdf) av Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

van den Broek, Sara Lopes; Shalgunov, Vladimir; Vazquez, Rocio Garcia; Beschorner, Natalie et al.

Ingår i Pharmaceuticals, 2022

• DOI för Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?
• Ladda ner fulltext (pdf) av Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Meier, Silvio R.; Sehlin, Dag; Roshanbin, Sahar; Lim Falk, Victoria et al.

Ingår i Journal of Nuclear Medicine, s. 302-309, 2022

• DOI för ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
• Ladda ner fulltext (pdf) av ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Ingår i Science Translational Medicine, 2021

• DOI för The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken et al.

Ingår i Translational Neurodegeneration, 2021

• DOI för Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
• Ladda ner fulltext (pdf) av Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Rofo, Fadi; Yilmaz, Canan Ugur; Metzendorf, Nicole G.; Gustavsson, Tobias et al.

Ingår i Theranostics, s. 789-804, 2021

• DOI för Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
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Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Faresjö, Rebecca; Bonvicini, Gillian; Fang, Xiaotian T.; Aguilar, Ximena et al.

Ingår i Fluids and Barriers of the CNS, 2021

• DOI för Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
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In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease

Xiong, Mengfei; Roshanbin, Sahar; Rokka, Johanna; Schlein, Eva et al.

Ingår i NeuroImage, 2021

• DOI för In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease
• Ladda ner fulltext (pdf) av In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease

Meier, Silvio R.; Sehlin, Dag; Hultqvist, Greta; Syvänen, Stina

Ingår i Molecular Imaging and Biology, s. 665-675, 2021

• DOI för Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease
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Extracellular vesicles from amyloid-beta exposed cell cultures induce severe dysfunction in cortical neurons

Beretta, Chiara; Nikitidou, Elisabeth; Gallasch, Linn; Ingelsson, Martin et al.

Ingår i Scientific Reports, 2020

• DOI för Extracellular vesicles from amyloid-beta exposed cell cultures induce severe dysfunction in cortical neurons
• Ladda ner fulltext (pdf) av Extracellular vesicles from amyloid-beta exposed cell cultures induce severe dysfunction in cortical neurons

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

Syvänen, Stina; Fang, Xiaotian T.; Faresjö, Rebecca; Rokka, Johanna et al.

Ingår i ACS Chemical Neuroscience, s. 4460-4468, 2020

• DOI för Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
• Ladda ner fulltext (pdf) av Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Syvänen, Stina; O'Callaghan, Paul; Sehlin, Dag

Ingår i Translational Neurodegeneration, 2020

• DOI för SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease
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Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

Sehlin, Dag; Stocki, Pawel; Gustavsson, Tobias; Hultqvist, Greta et al.

Ingår i The FASEB Journal, s. 13272-13283, 2020

• DOI för Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
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Chemical imaging of evolving amyloid plaque pathology and associated A β peptide aggregation in a transgenic mouse model of Alzheimer's disease

Michno, Wojciech; Wehrli, Patrick; Meier, Silvio R.; Sehlin, Dag et al.

Ingår i Journal of Neurochemistry, s. 602-616, 2020

• DOI för Chemical imaging of evolving amyloid plaque pathology and associated A β peptide aggregation in a transgenic mouse model of Alzheimer's disease

Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus

Abu Hamdeh, Sami; Virhammar, Johan; Sehlin, Dag; Alafuzoff, Irina et al.

Ingår i Journal of Neurosurgery, s. 121-129, 2019

• DOI för Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus

Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

Ingår i Scientific Reports, 2019

• DOI för Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
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Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

Zysk, Marlena; Clausen, Fredrik; Aguilar, Ximena; Sehlin, Dag et al.

Ingår i Journal of Alzheimer's Disease, s. 161-180, 2019

• DOI för Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease
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Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology

Michno, Wojciech; Nyström, Sofie; Wehrli, Patrick; Lashley, Tammaryn et al.

Ingår i Journal of Biological Chemistry, s. 6719-6732, 2019

• DOI för Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
• Ladda ner fulltext (pdf) av Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology

High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R.; Antoni, Gunnar et al.

Ingår i NeuroImage, s. 881-888, 2019

• DOI för High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death

Söllvander, Sofia; Nikitidou, Elisabeth; Gallasch, Linn; Zysk, Marlena et al.

Ingår i Journal of Neuroinflammation, 2018

• DOI för The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death
• Ladda ner fulltext (pdf) av The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death

Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells

Gustafsson, Gabriel; Lööv, Camilla; Persson, Emma; Lázaro, Diana F. et al.

Ingår i Cellular and molecular neurobiology, s. 1539-1550, 2018

• DOI för Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells
• Ladda ner fulltext (pdf) av Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells

Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Gustafsson, Sofia; Gustavsson, Tobias; Roshanbin, Sahar; Hultqvist, Greta et al.

Ingår i Neuropharmacology, s. 1-9, 2018

• DOI för Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
• Ladda ner fulltext (pdf) av Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Meier, Silvio R.; Syvänen, Stina; Hultqvist, Greta; Fang, Xiaotian T. et al.

Ingår i Journal of Nuclear Medicine, s. 1885-1891, 2018

• DOI för Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
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Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Syvänen, Stina; Hultqvist, Greta; Gustavsson, Tobias; Gumucio, Astrid et al.

Ingår i Alzheimer's Research & Therapy, 2018

• DOI för Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
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Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease

Olsen, Malin; Aguilar, Ximena; Sehlin, Dag; Fang, Xiaotian T. et al.

Ingår i Molecular Imaging and Biology, s. 605-614, 2018

• DOI för Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease
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Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

Fang, Xiaotian T.; Sehlin, Dag; Lannfelt, Lars; Syvänen, Stina et al.

Ingår i Biological Procedures Online, 2017

• DOI för Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
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Efficient clearance of Amyloid-beta protofibrils in APP-transgenic mice treated with a brain penetrating bifunctional antibody

Sehlin, Dag; Hultqvist, Greta; Gumucio, Astrid; Laudon, H. et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 415-416, 2017

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars et al.

Ingår i Theranostics, s. 308-318, 2017

• DOI för Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
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Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry

Kaya, Ibrahim; Brinet, Dimitri; Michno, Wojciech; Syvänen, Stina et al.

Ingår i ACS Chemical Neuroscience, s. 347-355, 2017

• DOI för Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry
• Ladda ner fulltext (pdf) av Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-beta

Sehlin, Dag; Fang, Xiaotian T.; Meier, Silvio R.; Jansson, Malin et al.

Ingår i Scientific Reports, 2017

• DOI för Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-beta
• Ladda ner fulltext (pdf) av Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-beta

A small bispecific antibody-based construct based on bapineuzumab as a PET tracer for amyloid beta pathology in brain

Fang, Xiaotian; Hultqvist, Greta; Meier, Silvio; Sehlin, Dag et al.

Ingår i Meeting abstract, 2017

Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')₂ fragment

Syvänen, Stina; Edén, Desireé; Sehlin, Dag

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 120-125, 2017

• DOI för Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')₂ fragment
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Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Ingår i Neuropharmacology, s. 293-300, 2017

• DOI för Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R. et al.

Ingår i NeuroImage, s. 55-63, 2017

• DOI för A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
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Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Sehlin, Dag; Fang, Xiaotian T.; Cato, Linda; Antoni, Gunnar et al.

Ingår i Nature Communications, 2016

• DOI för Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
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Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, Sofia; Nikitidou, Elisabeth; Brolin, Robin; Soderberg, Linda et al.

Ingår i Molecular Neurodegeneration, 2016

• DOI för Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
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Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, Sofia; Nikitidou, Elisabeth; Brolin, Robin; Söderberg, Linda et al.

Ingår i Molecular Neurodegeneration, 2016

Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease

Söllvander, Sofia; Ekholm-Pettersson, Frida; Brundin, Rose-Marie; Westman, Gabriel et al.

Ingår i Journal of Alzheimer's Disease, s. 63-72, 2015

• DOI för Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease
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Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

O'Callaghan, Paul; Noborn, Fredrik; Sehlin, Dag; Li, Jin-ping et al.

Ingår i Amyloid, s. 76-87, 2014

• DOI för Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease

Westman, Gabriel; Berglund, David; Widen, Johan; Ingelsson, Martin et al.

Ingår i PLOS ONE, 2014

• DOI för Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease
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Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain

Magnusson, Kristina; Sehlin, Dag; Syvänen, Stina; Svedberg, Marie M. et al.

Ingår i Journal of Alzheimer's Disease, s. 29-40, 2013

• DOI för Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain

Large Aggregates Are the Major Soluble Ab Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Sehlin, Dag; Englund, Hillevi; Simu, Barbro; Karlsson, Mikael et al.

Ingår i PLOS ONE, 2012

• DOI för Large Aggregates Are the Major Soluble Ab Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-A beta Antibodies

Sehlin, Dag; Hedlund, Marie; Lord, Anna; Englund, Hillevi et al.

Ingår i Neurodegenerative Diseases, s. 117-123, 2011

• DOI för Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-A beta Antibodies

Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease

Kamali-Moghaddam, Masood; Ekholm Pettersson, Frida; Wu, Di; Englund, Hillevi et al.

Ingår i BMC Neuroscience, s. 124, 2010

• DOI för Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease

Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs

Sehlin, Dag; Söllvander, Sofia; Paulie, Staffan; Brundin, RoseMarie et al.

Ingår i Journal of Alzheimer's Disease, s. 1295-1301, 2010

• DOI för Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

Lord, Anna; Gumucio, Astrid; Englund, Hillevi; Sehlin, Dag et al.

Ingår i Neurobiology of Disease, s. 425-434, 2009

• DOI för An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

Sensitive ELISA detection of amyloid-β protofibrils in biological samples

Englund, Hillevi; Sehlin, Dag; Johansson, Ann-Sofi; Nilsson, Lars N.G. et al.

Ingår i Journal of Neurochemistry, s. 334-345, 2007

• DOI för Sensitive ELISA detection of amyloid-β protofibrils in biological samples

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid-β fibril formation

Pagnon de la Vega, María; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Ingår i Science Translational Medicine

PET Imaging in Preclinical Anti-Aβ Drug Development

Syvänen, Stina; Meier, Silvio R.; Roshanbin, Sahar; Xiong, Mengfei et al.

Ingår i Pharmaceutical research, s. 1481-1496, 2022

• DOI för PET Imaging in Preclinical Anti-Aβ Drug Development
• Ladda ner fulltext (pdf) av PET Imaging in Preclinical Anti-Aβ Drug Development

Engineered antibodies: new possibilities for brain PET?

Sehlin, Dag; Syvänen, Stina; Ballanger, Benedicte; Barthel, Henryk et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 2848-2858, 2019

• DOI för Engineered antibodies: new possibilities for brain PET?
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Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease

Lannfelt, Lars; Moller, Christer; Basun, Hans; Osswald, Gunilla et al.

Ingår i ALZHEIMERS RES THER, s. 16, 2014

• DOI för Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease
• Ladda ner fulltext (pdf) av Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease

Aβ Conformation Dependent Antibodies and Alzheimer's Disease

Sehlin, Dag

2010

• Ladda ner fulltext (pdf) av Aβ Conformation Dependent Antibodies and Alzheimer's Disease

Therapeutic and diagnostic potential of a multivalent antibody against soluble amyloid-beta aggregates

Meier, Silvio R.; Rofo, Fadi; metzendorf, Nicole; Jamie, Morrison et al.

Transgenic mice harboring the Uppsala APP mutation display altered APP processing and accelerated Aβ42 pathology with distinct structural features

Pagnon de la Vega, María; Syvänen, Stina; Hooley, Monique; Giedraitis, Vilmantas et al.

The Uppsala APP mutation promotes wildtype Aβ aggregation and deposition in vivo

Pagnon de la Vega, María; Ge, Junyue; Giedraitis, Vilmantas; Syvänen, Stina et al.

Single domain antibody conjugated to Aβ-binding scFv penetrates BBB via TfR to interact with Aβ

Faresjö, Rebecca; O Sjöström, Elisabet; Berglund, Magnus; Eriksson, Jonas et al.

Synaptic density in aging mice measured by [¹⁸F]SynVesT-1 PET

Xiong, Mengfei; Roshanbin, Sahar; Sehlin, Dag; Hansen, Hanne D. et al.

[¹¹C]PiB binding after treatment with an amyloid-beta antibody

Xiong, Mengfei; Dahlén, Amelia; Roshanbin, Sahar; Aguilar, Ximena et al.

Aβ targeting ImmunoPET: Brain pharmacokinetics comparison between a brain penetrating and a regular antibody

Schlein, Eva; Lopes van den Broek, Sara; Dallas, Tiffany; Andersson, Ken G. et al.

Reduced neonatal Fc receptor binding increases clearance and brain-to-blood ratio of a brain penetrating amyloid-β antibody

Schlein, Eva; Andersson, Ken G.; Dallas, Tiffany; Syvänen, Stina et al.

Stronger affinity to Transferrin receptor enhances detection of amyloid-β pathology with bispecific antibody radioligands at a tracer dose

Bonvicini, Gillian; Singh, Sunitha; Sandersjöö, Lisa; Dallas, Tiffany et al.

Evaluation of valency effects on TfR-mediated brain delivery in vivo

Bonvicini, Gillian; Singh, Sunitha; Sandersjöö, Lisa; Sehlin, Dag et al.

Astrocytes with Alzheimer’s disease pathology provoke lipid droplet mediated cell-to-cell propagation of MHC II complexes

Beretta, Chiara; Dakhel, Abdulkhalek; Eltom, Khalid; Rosqvist, Fredrik et al.