Dag Sehlin

Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Schlein, Eva; Andersson, Ken G.; Dallas, Tiffany; Syvänen, Stina et al.

Ingår i mAbs, 2024

• DOI för Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
• Ladda ner fulltext (pdf) av Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
• Ladda ner fulltext (pdf) av Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Alzheimer's Research & Therapy, 2023

• DOI för Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
• Ladda ner fulltext (pdf) av Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Meier, Silvio R.; Sehlin, Dag; Roshanbin, Sahar; Lim Falk, Victoria et al.

Ingår i Journal of Nuclear Medicine, s. 302-309, 2022

• DOI för ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
• Ladda ner fulltext (pdf) av ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Ingår i Science Translational Medicine, 2021

• DOI för The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Syvänen, Stina; O'Callaghan, Paul; Sehlin, Dag

Ingår i Translational Neurodegeneration, 2020

• DOI för SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease
• Ladda ner fulltext (pdf) av SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease

Engineered antibodies: new possibilities for brain PET?

Sehlin, Dag; Syvänen, Stina; Ballanger, Benedicte; Barthel, Henryk et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 2848-2858, 2019

• DOI för Engineered antibodies: new possibilities for brain PET?
• Ladda ner fulltext (pdf) av Engineered antibodies: new possibilities for brain PET?

Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Syvänen, Stina; Hultqvist, Greta; Gustavsson, Tobias; Gumucio, Astrid et al.

Ingår i Alzheimer's Research & Therapy, 2018

• DOI för Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
• Ladda ner fulltext (pdf) av Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars et al.

Ingår i Theranostics, s. 308-318, 2017

• DOI för Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
• Ladda ner fulltext (pdf) av Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Sehlin, Dag; Fang, Xiaotian T.; Cato, Linda; Antoni, Gunnar et al.

Ingår i Nature Communications, 2016

• DOI för Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
• Ladda ner fulltext (pdf) av Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Sensitive ELISA detection of amyloid-β protofibrils in biological samples

Englund, Hillevi; Sehlin, Dag; Johansson, Ann-Sofi; Nilsson, Lars N.G. et al.

Ingår i Journal of Neurochemistry, s. 334-345, 2007

• DOI för Sensitive ELISA detection of amyloid-β protofibrils in biological samples

Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Dahlén, Amelia; Roshanbin, Sahar; Bucher, Nadja M.; Sehlin, Dag et al.

Ingår i Experimental Neurology, 2026

• DOI för Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies
• Ladda ner fulltext (pdf) av Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Lopes van den Broek, Sara; Eriksson, Jonas; Yang, Qiaojun; Bucher, Nadja M. et al.

Ingår i Translational Neurodegeneration, 2025

• DOI för Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine
• Ladda ner fulltext (pdf) av Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Metzendorf, Nicole G.; Sehlin, Dag; Hultqvist, Greta

Ingår i Frontiers in Neuroscience, 2025

• DOI för Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
• Ladda ner fulltext (pdf) av Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Zielinski, Mara; Peralta Reyes, Fernanda S.; Gremer, Lothar; Sommerhage, Simon et al.

Ingår i Acta neuropathologica communications, 2025

• DOI för Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)
• Ladda ner fulltext (pdf) av Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

Sehlin, Dag; Hultqvist, Greta; Michno, Wojciech; Aguilar, Ximena et al.

Ingår i The Journal of Prevention of Alzheimer's Disease, 2025

• DOI för Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease
• Ladda ner fulltext (pdf) av Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Dahlén, Amelia; Roshanbin, Sahar; Bucher, Nadja M.; Sehlin, Dag et al.

Ingår i Experimental Neurology, 2026

• DOI för Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies
• Ladda ner fulltext (pdf) av Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Lopes van den Broek, Sara; Eriksson, Jonas; Yang, Qiaojun; Bucher, Nadja M. et al.

Ingår i Translational Neurodegeneration, 2025

• DOI för Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine
• Ladda ner fulltext (pdf) av Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Metzendorf, Nicole G.; Sehlin, Dag; Hultqvist, Greta

Ingår i Frontiers in Neuroscience, 2025

• DOI för Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
• Ladda ner fulltext (pdf) av Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Zielinski, Mara; Peralta Reyes, Fernanda S.; Gremer, Lothar; Sommerhage, Simon et al.

Ingår i Acta neuropathologica communications, 2025

• DOI för Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)
• Ladda ner fulltext (pdf) av Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

Sehlin, Dag; Hultqvist, Greta; Michno, Wojciech; Aguilar, Ximena et al.

Ingår i The Journal of Prevention of Alzheimer's Disease, 2025

• DOI för Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease
• Ladda ner fulltext (pdf) av Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease

Sehlin, Dag; Aguilar, Ximena; Cortes-Canteli, Marta; Syvänen, Stina et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease
• Ladda ner fulltext (pdf) av Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease

Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology

Schlein, Eva; Lopes van den Broek, Sara; Dallas, Tiffany; Andersson, Ken G. et al.

Ingår i ACS Pharmacology & Translational Science, s. 2804-2813, 2025

• DOI för Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology
• Ladda ner fulltext (pdf) av Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology

High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

Bonvicini, Gillian; Singh, Sunitha; Sandersjoo, Lisa; Dallas, Tiffany et al.

Ingår i Fluids and Barriers of the CNS, 2025

• DOI för High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose
• Ladda ner fulltext (pdf) av High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET

Gonzalez-Arjona, Mario; Cusso, Lorena; Alcala, Luis; Gonzalez, Maria Isabel et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET
• Ladda ner fulltext (pdf) av Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET

Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

de la Rosa, Andrés; Metzendorf, Nicole G.; Efverström, Jonathan; Godec, Ana et al.

Ingår i Neurotherapeutics, 2025

• DOI för Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
• Ladda ner fulltext (pdf) av Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology

Sehlin, Dag; Roshanbin, Sahar; Zachrisson, Olof; Ingelsson, Martin et al.

Ingår i Neurotherapeutics, 2025

• DOI för A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
• Ladda ner fulltext (pdf) av A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology

Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery

Beretta, Chiara; Dakhel, Abdulkhalek; Eltom, Khalid; Rosqvist, Fredrik et al.

Ingår i Journal of Neuroinflammation, 2025

• DOI för Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
• Ladda ner fulltext (pdf) av Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery

Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

Lee, Yea-Rin; Kaya, Ibrahim; Wik, Elin; Baijnath, Sooraj et al.

Ingår i Analytical Chemistry, s. 1338-1346, 2025

• DOI för Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
• Ladda ner fulltext (pdf) av Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

Bonvicini, Gillian; Singh, Sunitha; Sandersjoo, Lisa; Sehlin, Dag et al.

Ingår i Fluids and Barriers of the CNS, 2025

• DOI för The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
• Ladda ner fulltext (pdf) av The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

Klingstedt, Therése; Shirani, Hamid; Parvin, Farjana; Nyström, Sofie et al.

Ingår i Journal of Biological Chemistry, 2025

• DOI för Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
• Ladda ner fulltext (pdf) av Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Petersen, Inga; Morrison, Jamie I.; Petrovic, Alex; Babic, Neira et al.

Ingår i Scientific Reports, 2024

• DOI för A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
• Ladda ner fulltext (pdf) av A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Schlein, Eva; Andersson, Ken G.; Dallas, Tiffany; Syvänen, Stina et al.

Ingår i mAbs, 2024

• DOI för Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
• Ladda ner fulltext (pdf) av Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity

Bonvicini, Gillian; Singh, Sunitha; Nygren, Patrik; Xiong, Mengfei et al.

Ingår i Analytical Biochemistry, 2024

• DOI för Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
• Ladda ner fulltext (pdf) av Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity

Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging

Xiong, Mengfei; Dahlén, Amelia; Roshanbin, Sahar; Wik, Elin et al.

Ingår i Journal of Neurochemistry, s. 2601-2610, 2024

• DOI för Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging
• Ladda ner fulltext (pdf) av Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging

Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β

Faresjö, Rebecca; Sjöström, Elisabet O.; Dallas, Tiffany; Berglund, Magnus M. et al.

Ingår i mAbs, 2024

• DOI för Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
• Ladda ner fulltext (pdf) av Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β

Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging

Gustavsson, Tobias; Herth, Matthias M.; Sehlin, Dag; Syvänen, Stina

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
• Ladda ner fulltext (pdf) av Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging

Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms

Beretta, Chiara; Svensson, Elina; Dakhel, Abdulkhalek; Zyśk, Marlena et al.

Ingår i Molecular and Cellular Neuroscience, 2024

• DOI för Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
• Ladda ner fulltext (pdf) av Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms

Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Schlein, Eva; Rokka, Johanna; Odell, Luke R.; Lopes van den Broek, Sara et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
• Ladda ner fulltext (pdf) av Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
• Ladda ner fulltext (pdf) av Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau

Banka, Vinay; Kelleher, Andrew; Sehlin, Dag; Hultqvist, Greta et al.

Ingår i Frontiers in Nuclear Medicine, 2023

• DOI för Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
• Ladda ner fulltext (pdf) av Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau

Synaptic density in aging mice measured by [18F]SynVesT-1 PET

Xiong, Mengfei; Roshanbin, Sahar; Sehlin, Dag; Hansen, Hanne D. et al.

Ingår i NeuroImage, 2023

• DOI för Synaptic density in aging mice measured by [18F]SynVesT-1 PET
• Ladda ner fulltext (pdf) av Synaptic density in aging mice measured by [18F]SynVesT-1 PET

Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease

Zielinski, Mara; Peralta Reyes, Fernanda S; Gremer, Lothar; Schemmert, Sarah et al.

Ingår i Nature Neuroscience, s. 2073-2080, 2023

• DOI för Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease
• Ladda ner fulltext (pdf) av Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Alzheimer's Research & Therapy, 2023

• DOI för Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
• Ladda ner fulltext (pdf) av Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Faresjö, Rebecca; Sehlin, Dag; Syvänen, Stina

Ingår i Fluids and Barriers of the CNS, 2023

• DOI för Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
• Ladda ner fulltext (pdf) av Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Ingår i Neurotherapeutics, s. 1588-1602, 2022

• DOI för A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
• Ladda ner fulltext (pdf) av A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

van den Broek, Sara Lopes; Sehlin, Dag; Andersen, Jens V.; Aldana, Blanca I. et al.

Ingår i Frontiers in Nuclear Medicine, 2022

• DOI för The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
• Ladda ner fulltext (pdf) av The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins

Bidesi, Natasha Shalina Radjani; Battisti, Umberto Maria; van de Broek, Sara Lopes; Shalgunov, Vladimir et al.

Ingår i ChemBioChem, 2022

• DOI för Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins
• Ladda ner fulltext (pdf) av Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins

Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Julku, Ulrika; Xiong, Mengfei; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Fluids and Barriers of the CNS, 2022

• DOI för Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis
• Ladda ner fulltext (pdf) av Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

Faresjö, Rebecca; Lindberg, Hanna; Stahl, Stefan; Lofblom, John et al.

Ingår i Pharmaceutical research, s. 1509-1521, 2022

• DOI för Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies
• Ladda ner fulltext (pdf) av Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas et al.

Ingår i Pharmaceutics, 2022

• DOI för Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
• Ladda ner fulltext (pdf) av Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

In vivo imaging of alpha-synuclein with antibody-based PET

Roshanbin, Sahar; Xiong, Mengfei; Hultqvist, Greta; Soderberg, Linda et al.

Ingår i Neuropharmacology, 2022

• DOI för In vivo imaging of alpha-synuclein with antibody-based PET
• Ladda ner fulltext (pdf) av In vivo imaging of alpha-synuclein with antibody-based PET

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein

Bonvicini, Gillian; Syvänen, Stina; Andersson, Ken G. G.; Haaparanta-Solin, Merja et al.

Ingår i Translational Neurodegeneration, 2022

• DOI för ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein
• Ladda ner fulltext (pdf) av ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Schlein, Eva; Syvänen, Stina; Rokka, Johanna; Gustavsson, Tobias et al.

Ingår i Molecular Pharmaceutics, s. 4111-4122, 2022

• DOI för Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging
• Ladda ner fulltext (pdf) av Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Passive and receptor mediated brain delivery of an anti-GFAP nanobody

Meier, Silvio R.; Sehlin, Dag; Syvänen, Stina

Ingår i Nuclear Medicine and Biology, s. 128-134, 2022

• DOI för Passive and receptor mediated brain delivery of an anti-GFAP nanobody
• Ladda ner fulltext (pdf) av Passive and receptor mediated brain delivery of an anti-GFAP nanobody

Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura et al.

Ingår i Alzheimer's Research & Therapy, 2022

• DOI för Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
• Ladda ner fulltext (pdf) av Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

van den Broek, Sara Lopes; Shalgunov, Vladimir; Vazquez, Rocio Garcia; Beschorner, Natalie et al.

Ingår i Pharmaceuticals, 2022

• DOI för Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?
• Ladda ner fulltext (pdf) av Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Meier, Silvio R.; Sehlin, Dag; Roshanbin, Sahar; Lim Falk, Victoria et al.

Ingår i Journal of Nuclear Medicine, s. 302-309, 2022

• DOI för ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
• Ladda ner fulltext (pdf) av ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken et al.

Ingår i Translational Neurodegeneration, 2021

• DOI för Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
• Ladda ner fulltext (pdf) av Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Rofo, Fadi; Yilmaz, Canan Ugur; Metzendorf, Nicole G.; Gustavsson, Tobias et al.

Ingår i Theranostics, s. 789-804, 2021

• DOI för Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
• Ladda ner fulltext (pdf) av Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Faresjö, Rebecca; Bonvicini, Gillian; Fang, Xiaotian T.; Aguilar, Ximena et al.

Ingår i Fluids and Barriers of the CNS, 2021

• DOI för Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
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In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease

Xiong, Mengfei; Roshanbin, Sahar; Rokka, Johanna; Schlein, Eva et al.

Ingår i NeuroImage, 2021

• DOI för In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease
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The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Ingår i Science Translational Medicine, 2021

• DOI för The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease

Meier, Silvio R.; Sehlin, Dag; Hultqvist, Greta; Syvänen, Stina

Ingår i Molecular Imaging and Biology, s. 665-675, 2021

• DOI för Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease
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Extracellular vesicles from amyloid-beta exposed cell cultures induce severe dysfunction in cortical neurons

Beretta, Chiara; Nikitidou, Elisabeth; Gallasch, Linn; Ingelsson, Martin et al.

Ingår i Scientific Reports, 2020

• DOI för Extracellular vesicles from amyloid-beta exposed cell cultures induce severe dysfunction in cortical neurons
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Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

Syvänen, Stina; Fang, Xiaotian T.; Faresjö, Rebecca; Rokka, Johanna et al.

Ingår i ACS Chemical Neuroscience, s. 4460-4468, 2020

• DOI för Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
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SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Syvänen, Stina; O'Callaghan, Paul; Sehlin, Dag

Ingår i Translational Neurodegeneration, 2020

• DOI för SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease
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Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

Sehlin, Dag; Stocki, Pawel; Gustavsson, Tobias; Hultqvist, Greta et al.

Ingår i The FASEB Journal, s. 13272-13283, 2020

• DOI för Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
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Chemical imaging of evolving amyloid plaque pathology and associated A β peptide aggregation in a transgenic mouse model of Alzheimer's disease

Michno, Wojciech; Wehrli, Patrick; Meier, Silvio R.; Sehlin, Dag et al.

Ingår i Journal of Neurochemistry, s. 602-616, 2020

• DOI för Chemical imaging of evolving amyloid plaque pathology and associated A β peptide aggregation in a transgenic mouse model of Alzheimer's disease

Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus

Abu Hamdeh, Sami; Virhammar, Johan; Sehlin, Dag; Alafuzoff, Irina et al.

Ingår i Journal of Neurosurgery, s. 121-129, 2019

• DOI för Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus

Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

Ingår i Scientific Reports, 2019

• DOI för Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
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Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

Zysk, Marlena; Clausen, Fredrik; Aguilar, Ximena; Sehlin, Dag et al.

Ingår i Journal of Alzheimer's Disease, s. 161-180, 2019

• DOI för Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease
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Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology

Michno, Wojciech; Nyström, Sofie; Wehrli, Patrick; Lashley, Tammaryn et al.

Ingår i Journal of Biological Chemistry, s. 6719-6732, 2019

• DOI för Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
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High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R.; Antoni, Gunnar et al.

Ingår i NeuroImage, s. 881-888, 2019

• DOI för High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death

Söllvander, Sofia; Nikitidou, Elisabeth; Gallasch, Linn; Zysk, Marlena et al.

Ingår i Journal of Neuroinflammation, 2018

• DOI för The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death
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Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells

Gustafsson, Gabriel; Lööv, Camilla; Persson, Emma; Lázaro, Diana F. et al.

Ingår i Cellular and molecular neurobiology, s. 1539-1550, 2018

• DOI för Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells
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Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Gustafsson, Sofia; Gustavsson, Tobias; Roshanbin, Sahar; Hultqvist, Greta et al.

Ingår i Neuropharmacology, s. 1-9, 2018

• DOI för Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
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Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Meier, Silvio R.; Syvänen, Stina; Hultqvist, Greta; Fang, Xiaotian T. et al.

Ingår i Journal of Nuclear Medicine, s. 1885-1891, 2018

• DOI för Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
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Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Syvänen, Stina; Hultqvist, Greta; Gustavsson, Tobias; Gumucio, Astrid et al.

Ingår i Alzheimer's Research & Therapy, 2018

• DOI för Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
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Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease

Olsen, Malin; Aguilar, Ximena; Sehlin, Dag; Fang, Xiaotian T. et al.

Ingår i Molecular Imaging and Biology, s. 605-614, 2018

• DOI för Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease
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Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

Fang, Xiaotian T.; Sehlin, Dag; Lannfelt, Lars; Syvänen, Stina et al.

Ingår i Biological Procedures Online, 2017

• DOI för Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
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Efficient clearance of Amyloid-beta protofibrils in APP-transgenic mice treated with a brain penetrating bifunctional antibody

Sehlin, Dag; Hultqvist, Greta; Gumucio, Astrid; Laudon, H. et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 415-416, 2017

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars et al.

Ingår i Theranostics, s. 308-318, 2017

• DOI för Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
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Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry

Kaya, Ibrahim; Brinet, Dimitri; Michno, Wojciech; Syvänen, Stina et al.

Ingår i ACS Chemical Neuroscience, s. 347-355, 2017

• DOI för Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry
• Ladda ner fulltext (pdf) av Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-beta

Sehlin, Dag; Fang, Xiaotian T.; Meier, Silvio R.; Jansson, Malin et al.

Ingår i Scientific Reports, 2017

• DOI för Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-beta
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A small bispecific antibody-based construct based on bapineuzumab as a PET tracer for amyloid beta pathology in brain

Fang, Xiaotian; Hultqvist, Greta; Meier, Silvio; Sehlin, Dag et al.

Ingår i Meeting abstract, 2017

Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')₂ fragment

Syvänen, Stina; Edén, Desireé; Sehlin, Dag

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 120-125, 2017

• DOI för Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')₂ fragment
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Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Ingår i Neuropharmacology, s. 293-300, 2017

• DOI för Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R. et al.

Ingår i NeuroImage, s. 55-63, 2017

• DOI för A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
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Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Sehlin, Dag; Fang, Xiaotian T.; Cato, Linda; Antoni, Gunnar et al.

Ingår i Nature Communications, 2016

• DOI för Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
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Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, Sofia; Nikitidou, Elisabeth; Brolin, Robin; Söderberg, Linda et al.

Ingår i Molecular Neurodegeneration, 2016

Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, Sofia; Nikitidou, Elisabeth; Brolin, Robin; Soderberg, Linda et al.

Ingår i Molecular Neurodegeneration, 2016

• DOI för Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
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Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease

Söllvander, Sofia; Ekholm-Pettersson, Frida; Brundin, Rose-Marie; Westman, Gabriel et al.

Ingår i Journal of Alzheimer's Disease, s. 63-72, 2015

• DOI för Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease
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Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

O'Callaghan, Paul; Noborn, Fredrik; Sehlin, Dag; Li, Jin-ping et al.

Ingår i Amyloid, s. 76-87, 2014

• DOI för Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease

Westman, Gabriel; Berglund, David; Widen, Johan; Ingelsson, Martin et al.

Ingår i PLOS ONE, 2014

• DOI för Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease
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Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain

Magnusson, Kristina; Sehlin, Dag; Syvänen, Stina; Svedberg, Marie M. et al.

Ingår i Journal of Alzheimer's Disease, s. 29-40, 2013

• DOI för Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain

Large Aggregates Are the Major Soluble Ab Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Sehlin, Dag; Englund, Hillevi; Simu, Barbro; Karlsson, Mikael et al.

Ingår i PLOS ONE, 2012

• DOI för Large Aggregates Are the Major Soluble Ab Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-A beta Antibodies

Sehlin, Dag; Hedlund, Marie; Lord, Anna; Englund, Hillevi et al.

Ingår i Neurodegenerative Diseases, s. 117-123, 2011

• DOI för Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-A beta Antibodies

Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease

Kamali-Moghaddam, Masood; Ekholm Pettersson, Frida; Wu, Di; Englund, Hillevi et al.

Ingår i BMC Neuroscience, s. 124, 2010

• DOI för Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease

Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs

Sehlin, Dag; Söllvander, Sofia; Paulie, Staffan; Brundin, RoseMarie et al.

Ingår i Journal of Alzheimer's Disease, s. 1295-1301, 2010

• DOI för Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

Lord, Anna; Gumucio, Astrid; Englund, Hillevi; Sehlin, Dag et al.

Ingår i Neurobiology of Disease, s. 425-434, 2009

• DOI för An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

Sensitive ELISA detection of amyloid-β protofibrils in biological samples

Englund, Hillevi; Sehlin, Dag; Johansson, Ann-Sofi; Nilsson, Lars N.G. et al.

Ingår i Journal of Neurochemistry, s. 334-345, 2007

• DOI för Sensitive ELISA detection of amyloid-β protofibrils in biological samples

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid-β fibril formation

Pagnon de la Vega, María; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Ingår i Science Translational Medicine

PET Imaging in Preclinical Anti-Aβ Drug Development

Syvänen, Stina; Meier, Silvio R.; Roshanbin, Sahar; Xiong, Mengfei et al.

Ingår i Pharmaceutical research, s. 1481-1496, 2022

• DOI för PET Imaging in Preclinical Anti-Aβ Drug Development
• Ladda ner fulltext (pdf) av PET Imaging in Preclinical Anti-Aβ Drug Development

Engineered antibodies: new possibilities for brain PET?

Sehlin, Dag; Syvänen, Stina; Ballanger, Benedicte; Barthel, Henryk et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 2848-2858, 2019

• DOI för Engineered antibodies: new possibilities for brain PET?
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Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease

Lannfelt, Lars; Moller, Christer; Basun, Hans; Osswald, Gunilla et al.

Ingår i ALZHEIMERS RES THER, s. 16, 2014

• DOI för Perspectives on future Alzheimer therapies: amyloid-beta protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease
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Aβ Conformation Dependent Antibodies and Alzheimer's Disease

Sehlin, Dag

2010

• Ladda ner fulltext (pdf) av Aβ Conformation Dependent Antibodies and Alzheimer's Disease

Therapeutic and diagnostic potential of a multivalent antibody against soluble amyloid-beta aggregates

Meier, Silvio R.; Rofo, Fadi; metzendorf, Nicole; Jamie, Morrison et al.

Transgenic mice harboring the Uppsala APP mutation display altered APP processing and accelerated Aβ42 pathology with distinct structural features

Pagnon de la Vega, María; Syvänen, Stina; Hooley, Monique; Giedraitis, Vilmantas et al.

The Uppsala APP mutation promotes wildtype Aβ aggregation and deposition in vivo

Pagnon de la Vega, María; Ge, Junyue; Giedraitis, Vilmantas; Syvänen, Stina et al.

Single domain antibody conjugated to Aβ-binding scFv penetrates BBB via TfR to interact with Aβ

Faresjö, Rebecca; O Sjöström, Elisabet; Berglund, Magnus; Eriksson, Jonas et al.

Synaptic density in aging mice measured by [¹⁸F]SynVesT-1 PET

Xiong, Mengfei; Roshanbin, Sahar; Sehlin, Dag; Hansen, Hanne D. et al.

[¹¹C]PiB binding after treatment with an amyloid-beta antibody

Xiong, Mengfei; Dahlén, Amelia; Roshanbin, Sahar; Aguilar, Ximena et al.

Aβ targeting ImmunoPET: Brain pharmacokinetics comparison between a brain penetrating and a regular antibody

Schlein, Eva; Lopes van den Broek, Sara; Dallas, Tiffany; Andersson, Ken G. et al.

Reduced neonatal Fc receptor binding increases clearance and brain-to-blood ratio of a brain penetrating amyloid-β antibody

Schlein, Eva; Andersson, Ken G.; Dallas, Tiffany; Syvänen, Stina et al.

Stronger affinity to Transferrin receptor enhances detection of amyloid-β pathology with bispecific antibody radioligands at a tracer dose

Bonvicini, Gillian; Singh, Sunitha; Sandersjöö, Lisa; Dallas, Tiffany et al.

Evaluation of valency effects on TfR-mediated brain delivery in vivo

Bonvicini, Gillian; Singh, Sunitha; Sandersjöö, Lisa; Sehlin, Dag et al.

Astrocytes with Alzheimer’s disease pathology provoke lipid droplet mediated cell-to-cell propagation of MHC II complexes

Beretta, Chiara; Dakhel, Abdulkhalek; Eltom, Khalid; Rosqvist, Fredrik et al.