Fredrik Frejd

HER2-targeted PET-imaging with [68Ga]Ga-ABY-025 to predict targeted-therapy response in HER2-expressing metastatic breast cancer: study protocol of a multicenter, prospective, open-label trial

Altena, Renske; Wiklander, Oscar P. B.; Susaeg Romdhani, Nour; Kistner, Anna et al.

Part of Frontiers in Oncology, 2026

• DOI for HER2-targeted PET-imaging with [68Ga]Ga-ABY-025 to predict targeted-therapy response in HER2-expressing metastatic breast cancer: study protocol of a multicenter, prospective, open-label trial
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Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer

Oroujeni, Maryam; Selvaraju, Ram Kumar; Persson, Helena; Dahllund, Leif et al.

Part of Nuclear medicine communications, p. 401-410, 2026

• DOI for Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
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Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Tolmachev, Vladimir; Herlina, Amelinda Janice; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A. et al.

Part of International Journal of Molecular Sciences, 2026

• DOI for Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model
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Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Mortensen, Anja C. L.; Mohajershojai, Tabassom; Gustafsson, Amanda; Berglund, Hanna et al.

Part of Journal of Nuclear Medicine, p. 269-275, 2026

• DOI for Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
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Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Tolmachev, Vladimir M.; Bezverkhniaia, Ekaterina; Papalanis, Eleftherios; Muhammad, Abdullah Mujahid Bin et al.

Part of ACS Pharmacology & Translational Science, p. 3509-3522, 2025

• DOI for Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68
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HER2-targeted PET-imaging with [68Ga]Ga-ABY-025 to predict targeted-therapy response in HER2-expressing metastatic breast cancer: study protocol of a multicenter, prospective, open-label trial

Altena, Renske; Wiklander, Oscar P. B.; Susaeg Romdhani, Nour; Kistner, Anna et al.

Part of Frontiers in Oncology, 2026

• DOI for HER2-targeted PET-imaging with [68Ga]Ga-ABY-025 to predict targeted-therapy response in HER2-expressing metastatic breast cancer: study protocol of a multicenter, prospective, open-label trial
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Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer

Oroujeni, Maryam; Selvaraju, Ram Kumar; Persson, Helena; Dahllund, Leif et al.

Part of Nuclear medicine communications, p. 401-410, 2026

• DOI for Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
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Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Tolmachev, Vladimir; Herlina, Amelinda Janice; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A. et al.

Part of International Journal of Molecular Sciences, 2026

• DOI for Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model
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Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Mortensen, Anja C. L.; Mohajershojai, Tabassom; Gustafsson, Amanda; Berglund, Hanna et al.

Part of Journal of Nuclear Medicine, p. 269-275, 2026

• DOI for Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
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Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Tolmachev, Vladimir M.; Bezverkhniaia, Ekaterina; Papalanis, Eleftherios; Muhammad, Abdullah Mujahid Bin et al.

Part of ACS Pharmacology & Translational Science, p. 3509-3522, 2025

• DOI for Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68
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PDGFR⟠targeted positron emission tomography as a non-invasive biomarker for activated hepatic stellate cells: lasts steps before clinical translation

Yashaswini, Chittampalli N.; Mitran, Bogdan; Papadopoulos, Natalia; Wegrzyniak, Olivia et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for PDGFR⟠targeted positron emission tomography as a non-invasive biomarker for activated hepatic stellate cells: lasts steps before clinical translation
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Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model

Hemmingsson, Jens; Nestor, Marika; Lundgren Mortensen, Anja; Frejd, Fredrik et al.

Part of Physics in Medicine and Biology, 2025

• DOI for Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model
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PET imaging of platelet derived growth factor receptor β in lung fibrosis

Wegrzyniak, Olivia; Lechi, Francesco; Rokka, Johanna; Mitran, Bogdan et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for PET imaging of platelet derived growth factor receptor β in lung fibrosis
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Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Tolmachev, Vladimir M.; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A.; Rosly, Alia Hani et al.

Part of ACS Pharmacology & Translational Science, p. 706-717, 2025

• DOI for Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules
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Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Mortensen, Anja; Berglund, Hanna; Jha, Preeti; Stenman, Adam et al.

Part of Molecular Cancer Therapeutics, p. 753-762, 2025

• DOI for Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
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Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Lundgren Mortensen, Anja Charlotte; Hofström, Camilla; Persson, Helena; Dahllund, Leif et al.

Part of Nuclear Medicine and Biology, 2025

• DOI for Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy
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[68Ga]Ga-ABY-025 PET in HER2-positive breast cancer: Benefits and pitfalls in staging of axillary disease

Alhuseinalkhudhur, Ali; Lindman, Henrik; Liss, Per; Frejd, Fredrik et al.

Part of Journal of Clinical Oncology, 2024

• DOI for [68Ga]Ga-ABY-025 PET in HER2-positive breast cancer: Benefits and pitfalls in staging of axillary disease

Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile

Liu, Yongsheng; Oroujeni, Maryam; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 4038-4048, 2024

• DOI for Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile
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Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Wegrzyniak, Olivia; Lechi, Francesco; Mitran, Bogdan; Cheung, Pierre et al.

Part of iScience, 2024

• DOI for Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
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Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA

Lechi, Francesco; Eriksson, Jonas; Odell, Luke R.; Wegrzyniak, Olivia et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2024

• DOI for Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
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Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation

Oroujeni, Maryam; Carlqvist, Matilda; Ryer, Eva; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2024

• DOI for Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation
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Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [ ⁶⁸ Ga]Ga-ABY-025: Results from a Pilot Study

Altena, Renske; af Buren, Siri; Blomgren, August; Karlsson, Emelie et al.

Part of Journal of Nuclear Medicine, p. 700-707, 2024

• DOI for Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [ ⁶⁸ Ga]Ga-ABY-025: Results from a Pilot Study

Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

Liu, Yongsheng; Xu, Tianqi; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Part of Cancers, 2023

• DOI for Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab
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Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis

Klint, Susanne; Feldwisch, Joachim; Gudmundsdotter, Lindvi; Bergstedt, Karin Dillner et al.

Part of mAbs, 2023

• DOI for Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis
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Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy

Mortensen, Anja; Berglund, Hanna; Segerström, Lova; Walle, M. et al.

Part of Scientific Reports, 2023

• DOI for Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy
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Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Part of Nuclear Medicine and Biology, 2023

• DOI for Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3
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Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Wegrzyniak, Olivia; Zhang, Bo; Rokka, Johanna; Rosestedt, Maria et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2023

• DOI for Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β
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Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II, randomized, placebo-controlled, double-blind, dose-finding multicentre study including long-term treatment

Gerdes, Sascha; Staubach, Petra; Dirschka, Thomas; Wetzel, Dieter et al.

Part of British Journal of Dermatology, p. 381-391, 2023

• DOI for Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II, randomized, placebo-controlled, double-blind, dose-finding multicentre study including long-term treatment
• Download full text (pdf) of Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II, randomized, placebo-controlled, double-blind, dose-finding multicentre study including long-term treatment

Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts

Mohajershojai, Tabassom; Spangler, Douglas; Chopra, Saloni; Frejd, Fredrik Y. et al.

Part of Cancers, 2023

• DOI for Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts
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Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer

Bragina, Olga; Chernov, Vladimir; Larkina, Mariia; Rybina, Anstasiya et al.

Part of Theranostics, p. 4858-4871, 2023

• DOI for Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer
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Human Epidermal Growth Factor Receptor 2-Targeting [⁶⁸Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.

Alhuseinalkhudhur, Ali; Lindman, Henrik; Liss, Per; Sundin, Tora et al.

Part of Journal of Nuclear Medicine, p. 1364-1370, 2023

• DOI for Human Epidermal Growth Factor Receptor 2-Targeting [⁶⁸Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.
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HER2-low breast cancer - A new entity that could expand possibilities of getting treatment

Altena, Renske; Tzortzakakis, Antonios; Sörensen, Jens; Frejd, Fredrik et al.

Part of Läkartidningen, 2022

Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071

Liu, Yongsheng; Vorobyeva, Anzhelika; Orlova, Anna; Konijnenberg, Mark W. et al.

Part of Pharmaceutics, 2022

• DOI for Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071
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Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Liu, Yongsheng; Gueler, Rezan; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Part of Pharmaceutics, 2022

• DOI for Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis
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Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Part of Pharmaceutics, 2022

• DOI for Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3
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In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer

Mohajershojai, Tabassom; Jha, Preeti; Bostroem, Anna; Frejd, Fredrik Y. et al.

Part of Frontiers in Oncology, 2022

• DOI for In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer
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Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Liu, Yongsheng; Vorobyeva, Anzhelika; Xu, Tianqi; Orlova, Anna et al.

Part of Pharmaceutics, 2021

• DOI for Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain
• Download full text (pdf) of Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Oroujeni, Maryam; Rinne, Sara S.; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Part of International Journal of Molecular Sciences, 2021

• DOI for Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake
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In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1

Rubins, Daniel J.; Meng, Xiangjun; McQuade, Paul; Klimas, Michael et al.

Part of Molecular Imaging and Biology, p. 241-249, 2021

• DOI for In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1

Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination

Volk, Anna-Luisa; Mebrahtu, Aman; Ko, Bong-Kook; Lundqvist, Magnus et al.

Part of Drugs in R&D, p. 157-168, 2021

• DOI for Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination
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Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer

Alhuseinalkhudhur, Ali; Lubberink, Mark; Lindman, Henrik; Tolmachev, Vladimir et al.

Part of EJNMMI Research, 2020

• DOI for Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer
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Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Garousi, Javad; Orlova, Anna; Frejd, Fredrik Y.; Tolmachev, Vladimir

Part of EJNMMI Radiopharmacy and Chemistry, 2020

• DOI for Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

Garousi, Javad; Huizing, Fokko J.; Vorobyeva, Anzhelika; Mitran, Bogdan et al.

Part of Scientific Reports, 2019

• DOI for Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts
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CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models

Huizing, Fokko J.; Garousi, Javad; Lok, Jasper; Franssen, Gerben et al.

Part of Scientific Reports, 2019

• DOI for CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models
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Diagnostic HER2-binding radiopharmaceutical, [Ga-68]Ga-ABY-025, for routine clinical use in breast cancer patients

Velikyan, Irina; Schweighoefer, Philip; Feldwisch, Joachim; Seemann, Johanna et al.

Part of American Journal of Nuclear Medicine and Molecular Imaging, p. 12-23, 2019

Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab

Orlova, Anna; Bass, Tarek Z.; Rinne, Sara S.; Leitao, Charles Dahlsson et al.

Part of Molecular Pharmaceutics, p. 3394-3403, 2018

• DOI for Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab

Kinetic Analysis of the HER2-binding ABY-025 Affibody Using Dynamic PET in Patients with Metastatic Breast Cancer

Alhuseinalkhudhur, Ali; Lubberink, Mark; Velikyan, Irina; Tolmachev, Vladimir et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

Same-day imaging using small proteins: Clinical experience and translational prospects in oncology.

Krasniqi, Ahmet; D'Huyvetter, Matthias; Devoogdt, Nick; Frejd, Fredrik Y. et al.

Part of Journal of Nuclear Medicine, p. 885-891, 2018

• DOI for Same-day imaging using small proteins: Clinical experience and translational prospects in oncology.

In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin- binding therapeutic affibody construct

Bass, Tarek Z.; Rosestedt, Maria; Mitran, Bogdan; Frejd, Fredrik Y. et al.

Part of Scientific Reports, 2017

• DOI for In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin- binding therapeutic affibody construct
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In Vivo Imaging of the Programmed Death Ligand 1 by F-18 PET

Trotter, Dinko E. Gonzalez; Meng, Xiangjun; McQuade, Paul; Rubins, Daniel et al.

Part of Journal of Nuclear Medicine, p. 1852-1857, 2017

• DOI for In Vivo Imaging of the Programmed Death Ligand 1 by F-18 PET

Comparative evaluation of Affibody molecules for radionuclide imaging of in vivo expression of carbonic anhydrase IX

Garousi, Javad; Honarvar, Hadis; Andersson, Ken G.; Mitran, Bogdan et al.

Part of Molecular Pharmaceutics, p. 3676-3687, 2016

• DOI for Comparative evaluation of Affibody molecules for radionuclide imaging of in vivo expression of carbonic anhydrase IX

Evaluation of Affibody Molecules for Radionuclide Imaging of Carbonic Abhydrase IX Expression In Vivo

Garousi, Javad; Honarvar, Hadis; Andersson, K.; Mitran, Bogdan et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

In vivo evaluation of pharmacokinetics, tumors targeting and therapeutic efficacy of a novel format of HER3-targeting affibody molecule with prolonged blood circulation

Orlova, Anna; Rosestedt, Maria; Mitran, Bogdan; Bass, T. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-ZCAIX: 1 Affibody molecule

Honarvar, Hadis; Garousi, Javad; Gunneriusson, Elin; Höidén-Guthenberg, Ingmarie et al.

Part of International Journal of Oncology, p. 513-20, 2015

• DOI for Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-ZCAIX: 1 Affibody molecule
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Target-specific cytotoxic effects on HER2-expressing cells by the tripartite fusion toxin Z(HER2:2891)-ABD-PE38X8, including a targeting affibody molecule and a half-life extension domain

Liu, Hao; Seijsing, Johan; Frejd, Fredrik Y.; Tolmachev, Vladimir et al.

Part of International Journal of Oncology, p. 601-609, 2015

• DOI for Target-specific cytotoxic effects on HER2-expressing cells by the tripartite fusion toxin Z(HER2:2891)-ABD-PE38X8, including a targeting affibody molecule and a half-life extension domain

Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension

Malm, Magdalena; Bass, Tarek; Gudmundsdotter, Lindvi; Lord, Martin et al.

Part of Biotechnology Journal, p. 1215-1222, 2014

• DOI for Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension

Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity

Fleetwood, Filippa; Klint, Susanne; Hanze, Martin; Gunneriusson, Elin et al.

Part of Scientific Reports, p. 7518, 2014

• DOI for Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity
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Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Hosseinimehr, Seyed Jalal et al.

Part of Journal of Nuclear Medicine, p. 294-300, 2014

• DOI for Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591
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An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Seijsing, Johan; Lindborg, Malin; Hoiden-Guthenberg, Ingmarie; Bonisch, Heiko et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 17110-17115, 2014

• DOI for An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-Z09781 Affibody molecule

Honarvar, Hadis; Garousi, Javad; Gunneriusson, E.; Hoiden-Guthenberg, I. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

Simultaneous dual-radionuclide SPECT-imaging of HER2 expression using 99mTc-Affibody/111In-trastuzumab

Ahlstedt, J.; Orbom, A.; Akesson, A.; Frejd, Fredrik et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification

Malm, Magdalena; Kronqvist, Nina; Lindberg, Hanna; Gudmundsdotter, Lindvi et al.

Part of PLOS ONE, 2013

• DOI for Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification
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Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein

Orlova, Anna; Jonsson, Andreas; Rosik, Daniel; Lundqvist, Hans et al.

Part of Journal of Nuclear Medicine, p. 961-968, 2013

• DOI for Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein
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Imaging of PDGFRbeta expression in vivo using Affibody molecule In-111-DOTA-Z09591

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Hosseinimehr, S. Jalal et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013

In vivo imaging of PDGFR beta expression using In-111-DOTA-Z09591 Affibody molecule

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Eriksson, Olof et al.

Part of Journal of labelled compounds & radiopharmaceuticals, 2013

Generation and Evaluation of Bispecific Affibody Molecules for Simultaneous Targeting of EGFR and HER2

Ekerljung, Lina; Wållberg, Helena; Sohrabian, Azita; Andersson, Karl et al.

Part of Bioconjugate chemistry, p. 1802-1811, 2012

• DOI for Generation and Evaluation of Bispecific Affibody Molecules for Simultaneous Targeting of EGFR and HER2

Cellular effects of HER3-specific affibody molecules

Göstring, Lovisa; Malm, Magdalena; Höidén-Guthenberg, Ingmarie; Frejd, Fredrik et al.

Part of PLOS ONE, 2012

• DOI for Cellular effects of HER3-specific affibody molecules
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Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor beta In Vivo

Lindborg, M.; Cortez, E.; Höiden-Guthenberg, I.; Gunneriusson, E. et al.

Part of Journal of Molecular Biology, p. 298-315, 2011

• DOI for Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor beta In Vivo

Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules

Kronqvist, Nina; Malm, Magdalena; Göstring, Lovisa; Gunneriusson, Elin et al.

Part of Protein Engineering Design & Selection, p. 385-396, 2011

• DOI for Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules

Non-immunoglobulin based protein scaffolds

Löfblom, John; Frejd, Fredrik Y; Ståhl, Stefan

Part of Current Opinion in Biotechnology, p. 843-848, 2011

• DOI for Non-immunoglobulin based protein scaffolds

Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

Göstring, Lovisa; Chew, Ming Tsuey; Orlova, Anna; Höidén-Guthenberg, Ingmarie et al.

Part of International Journal of Oncology, p. 757-763, 2010

• DOI for Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

Targeting of Epidermal Growth Factor Receptor (EGFR)-Expressing Tumor Cells with Sterically Stabilized Affibody Liposomes (SAL)

Beuttler, Julia; Rothdiener, Miriam; Mueller, Dafne; Frejd, Fredrik Y. et al.

Part of Bioconjugate chemistry, p. 1201-1208, 2009

• DOI for Targeting of Epidermal Growth Factor Receptor (EGFR)-Expressing Tumor Cells with Sterically Stabilized Affibody Liposomes (SAL)

Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding

Tolmachev, Vladimir; Mume, Eskender; Sjöberg, Stefan; Frejd, Fredrik Y. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 692-701, 2009

• DOI for Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding

Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule

Friedman, Mikaela; Lindstrom, Sara; Ekerljung, Lina; Andersson-Svahn, Helene et al.

Part of Biotechnology and applied biochemistry, p. 121-131, 2009

• DOI for Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule

Generation of tumour-necrosis-factor-alpha-specific affibody molecules capable of blocking receptor binding in vitro

Jonsson, Andreas; Wallberg, Helena; Herne, Nina; Ståhl, Stefan et al.

Part of Biotechnology and applied biochemistry, p. 93-103, 2009

• DOI for Generation of tumour-necrosis-factor-alpha-specific affibody molecules capable of blocking receptor binding in vitro

Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy

Eissler, Nina; Altena, Renske; Alhuseinalkhudhur, Ali; Bragina, Olga et al.

Part of Biomedicines, 2024

• DOI for Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy
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Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications

Altena, Renske; Tzortzakakis, Antonios; Buren, Siri Af; Tran, Thuy A. et al.

Part of EJNMMI Research, 2023

• DOI for Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications
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HER2-låg bröstcancer ny entitet: ökar behandlingsmöjligheterna

Altena, Renske; Tzortzakakis, Antonios; Sörensen, Jens; Frejd, Fredrik Y. et al.

Part of Läkartidningen, 2022

Affibody molecules as engineered protein drugs

Frejd, Fredrik Y.; Kim, Kyu-Tae

Part of Experimental and Molecular Medicine, 2017

• DOI for Affibody molecules as engineered protein drugs
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Affibody Molecules in Biotechnological and Medical Applications

Ståhl, Stefan; Gräslund, Torbjörn; Karlström, Amelie Eriksson; Frejd, Fredrik Y. et al.

Part of Trends in Biotechnology, p. 691-712, 2017

• DOI for Affibody Molecules in Biotechnological and Medical Applications

Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds

Malm, Magdalena; Frejd, Fredrik Y.; Ståhl, Stefan; Löfblom, John

Part of mAbs, p. 1195-1209, 2016

• DOI for Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds

Non-immunoglobulin based protein scaffolds

Löfblom, John; Frejd, Fredrik Y.; Ståhl, Stefan

Part of Current Opinion in Biotechnology, p. 843-848, 2011

• DOI for Non-immunoglobulin based protein scaffolds

Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications

Löfblom, John; Feldwisch, Joachim; Tolmachev, Vladimir; Carlsson, Jörgen et al.

Part of FEBS Letters, p. 2670-2680, 2010

• DOI for Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications