Fredrik Frejd

HER2-targeted PET-imaging with [68Ga]Ga-ABY-025 to predict targeted-therapy response in HER2-expressing metastatic breast cancer: study protocol of a multicenter, prospective, open-label trial

Altena, Renske; Wiklander, Oscar P. B.; Susaeg Romdhani, Nour; Kistner, Anna et al.

Ingår i Frontiers in Oncology, 2026

• DOI för HER2-targeted PET-imaging with [68Ga]Ga-ABY-025 to predict targeted-therapy response in HER2-expressing metastatic breast cancer: study protocol of a multicenter, prospective, open-label trial
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Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer

Oroujeni, Maryam; Selvaraju, Ram Kumar; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear medicine communications, s. 401-410, 2026

• DOI för Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
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Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Tolmachev, Vladimir; Herlina, Amelinda Janice; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A. et al.

Ingår i International Journal of Molecular Sciences, 2026

• DOI för Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model
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Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Mortensen, Anja C. L.; Mohajershojai, Tabassom; Gustafsson, Amanda; Berglund, Hanna et al.

Ingår i Journal of Nuclear Medicine, s. 269-275, 2026

• DOI för Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
• Ladda ner fulltext (pdf) av Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Tolmachev, Vladimir M.; Bezverkhniaia, Ekaterina; Papalanis, Eleftherios; Muhammad, Abdullah Mujahid Bin et al.

Ingår i ACS Pharmacology & Translational Science, s. 3509-3522, 2025

• DOI för Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68
• Ladda ner fulltext (pdf) av Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

HER2-targeted PET-imaging with [68Ga]Ga-ABY-025 to predict targeted-therapy response in HER2-expressing metastatic breast cancer: study protocol of a multicenter, prospective, open-label trial

Altena, Renske; Wiklander, Oscar P. B.; Susaeg Romdhani, Nour; Kistner, Anna et al.

Ingår i Frontiers in Oncology, 2026

• DOI för HER2-targeted PET-imaging with [68Ga]Ga-ABY-025 to predict targeted-therapy response in HER2-expressing metastatic breast cancer: study protocol of a multicenter, prospective, open-label trial
• Ladda ner fulltext (pdf) av HER2-targeted PET-imaging with [68Ga]Ga-ABY-025 to predict targeted-therapy response in HER2-expressing metastatic breast cancer: study protocol of a multicenter, prospective, open-label trial

Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer

Oroujeni, Maryam; Selvaraju, Ram Kumar; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear medicine communications, s. 401-410, 2026

• DOI för Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
• Ladda ner fulltext (pdf) av Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer

Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Tolmachev, Vladimir; Herlina, Amelinda Janice; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A. et al.

Ingår i International Journal of Molecular Sciences, 2026

• DOI för Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model
• Ladda ner fulltext (pdf) av Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Mortensen, Anja C. L.; Mohajershojai, Tabassom; Gustafsson, Amanda; Berglund, Hanna et al.

Ingår i Journal of Nuclear Medicine, s. 269-275, 2026

• DOI för Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
• Ladda ner fulltext (pdf) av Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Tolmachev, Vladimir M.; Bezverkhniaia, Ekaterina; Papalanis, Eleftherios; Muhammad, Abdullah Mujahid Bin et al.

Ingår i ACS Pharmacology & Translational Science, s. 3509-3522, 2025

• DOI för Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68
• Ladda ner fulltext (pdf) av Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

PDGFR⟠targeted positron emission tomography as a non-invasive biomarker for activated hepatic stellate cells: lasts steps before clinical translation

Yashaswini, Chittampalli N.; Mitran, Bogdan; Papadopoulos, Natalia; Wegrzyniak, Olivia et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för PDGFR⟠targeted positron emission tomography as a non-invasive biomarker for activated hepatic stellate cells: lasts steps before clinical translation
• Ladda ner fulltext (pdf) av PDGFR⟠targeted positron emission tomography as a non-invasive biomarker for activated hepatic stellate cells: lasts steps before clinical translation

Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model

Hemmingsson, Jens; Nestor, Marika; Lundgren Mortensen, Anja; Frejd, Fredrik et al.

Ingår i Physics in Medicine and Biology, 2025

• DOI för Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model
• Ladda ner fulltext (pdf) av Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model

PET imaging of platelet derived growth factor receptor β in lung fibrosis

Wegrzyniak, Olivia; Lechi, Francesco; Rokka, Johanna; Mitran, Bogdan et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för PET imaging of platelet derived growth factor receptor β in lung fibrosis
• Ladda ner fulltext (pdf) av PET imaging of platelet derived growth factor receptor β in lung fibrosis

Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Tolmachev, Vladimir M.; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A.; Rosly, Alia Hani et al.

Ingår i ACS Pharmacology & Translational Science, s. 706-717, 2025

• DOI för Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules
• Ladda ner fulltext (pdf) av Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Mortensen, Anja; Berglund, Hanna; Jha, Preeti; Stenman, Adam et al.

Ingår i Molecular Cancer Therapeutics, s. 753-762, 2025

• DOI för Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
• Ladda ner fulltext (pdf) av Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Lundgren Mortensen, Anja Charlotte; Hofström, Camilla; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear Medicine and Biology, 2025

• DOI för Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy
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[68Ga]Ga-ABY-025 PET in HER2-positive breast cancer: Benefits and pitfalls in staging of axillary disease

Alhuseinalkhudhur, Ali; Lindman, Henrik; Liss, Per; Frejd, Fredrik et al.

Ingår i Journal of Clinical Oncology, 2024

• DOI för [68Ga]Ga-ABY-025 PET in HER2-positive breast cancer: Benefits and pitfalls in staging of axillary disease

Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile

Liu, Yongsheng; Oroujeni, Maryam; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 4038-4048, 2024

• DOI för Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile
• Ladda ner fulltext (pdf) av Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile

Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Wegrzyniak, Olivia; Lechi, Francesco; Mitran, Bogdan; Cheung, Pierre et al.

Ingår i iScience, 2024

• DOI för Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
• Ladda ner fulltext (pdf) av Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA

Lechi, Francesco; Eriksson, Jonas; Odell, Luke R.; Wegrzyniak, Olivia et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
• Ladda ner fulltext (pdf) av Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA

Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation

Oroujeni, Maryam; Carlqvist, Matilda; Ryer, Eva; Orlova, Anna et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation
• Ladda ner fulltext (pdf) av Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation

Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [ ⁶⁸ Ga]Ga-ABY-025: Results from a Pilot Study

Altena, Renske; af Buren, Siri; Blomgren, August; Karlsson, Emelie et al.

Ingår i Journal of Nuclear Medicine, s. 700-707, 2024

• DOI för Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [ ⁶⁸ Ga]Ga-ABY-025: Results from a Pilot Study

Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

Liu, Yongsheng; Xu, Tianqi; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Ingår i Cancers, 2023

• DOI för Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab
• Ladda ner fulltext (pdf) av Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis

Klint, Susanne; Feldwisch, Joachim; Gudmundsdotter, Lindvi; Bergstedt, Karin Dillner et al.

Ingår i mAbs, 2023

• DOI för Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis
• Ladda ner fulltext (pdf) av Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis

Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy

Mortensen, Anja; Berglund, Hanna; Segerström, Lova; Walle, M. et al.

Ingår i Scientific Reports, 2023

• DOI för Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy
• Ladda ner fulltext (pdf) av Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy

Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Ingår i Nuclear Medicine and Biology, 2023

• DOI för Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3
• Ladda ner fulltext (pdf) av Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Wegrzyniak, Olivia; Zhang, Bo; Rokka, Johanna; Rosestedt, Maria et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2023

• DOI för Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β
• Ladda ner fulltext (pdf) av Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II, randomized, placebo-controlled, double-blind, dose-finding multicentre study including long-term treatment

Gerdes, Sascha; Staubach, Petra; Dirschka, Thomas; Wetzel, Dieter et al.

Ingår i British Journal of Dermatology, s. 381-391, 2023

• DOI för Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II, randomized, placebo-controlled, double-blind, dose-finding multicentre study including long-term treatment
• Ladda ner fulltext (pdf) av Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II, randomized, placebo-controlled, double-blind, dose-finding multicentre study including long-term treatment

Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts

Mohajershojai, Tabassom; Spangler, Douglas; Chopra, Saloni; Frejd, Fredrik Y. et al.

Ingår i Cancers, 2023

• DOI för Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts
• Ladda ner fulltext (pdf) av Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts

Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer

Bragina, Olga; Chernov, Vladimir; Larkina, Mariia; Rybina, Anstasiya et al.

Ingår i Theranostics, s. 4858-4871, 2023

• DOI för Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer
• Ladda ner fulltext (pdf) av Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer

Human Epidermal Growth Factor Receptor 2-Targeting [⁶⁸Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.

Alhuseinalkhudhur, Ali; Lindman, Henrik; Liss, Per; Sundin, Tora et al.

Ingår i Journal of Nuclear Medicine, s. 1364-1370, 2023

• DOI för Human Epidermal Growth Factor Receptor 2-Targeting [⁶⁸Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.
• Ladda ner fulltext (pdf) av Human Epidermal Growth Factor Receptor 2-Targeting [⁶⁸Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.

HER2-low breast cancer - A new entity that could expand possibilities of getting treatment

Altena, Renske; Tzortzakakis, Antonios; Sörensen, Jens; Frejd, Fredrik et al.

Ingår i Läkartidningen, 2022

Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071

Liu, Yongsheng; Vorobyeva, Anzhelika; Orlova, Anna; Konijnenberg, Mark W. et al.

Ingår i Pharmaceutics, 2022

• DOI för Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071
• Ladda ner fulltext (pdf) av Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071

Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Liu, Yongsheng; Gueler, Rezan; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Ingår i Pharmaceutics, 2022

• DOI för Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis
• Ladda ner fulltext (pdf) av Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Ingår i Pharmaceutics, 2022

• DOI för Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3
• Ladda ner fulltext (pdf) av Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer

Mohajershojai, Tabassom; Jha, Preeti; Bostroem, Anna; Frejd, Fredrik Y. et al.

Ingår i Frontiers in Oncology, 2022

• DOI för In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer
• Ladda ner fulltext (pdf) av In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer

Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Liu, Yongsheng; Vorobyeva, Anzhelika; Xu, Tianqi; Orlova, Anna et al.

Ingår i Pharmaceutics, 2021

• DOI för Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain
• Ladda ner fulltext (pdf) av Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Oroujeni, Maryam; Rinne, Sara S.; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake
• Ladda ner fulltext (pdf) av Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1

Rubins, Daniel J.; Meng, Xiangjun; McQuade, Paul; Klimas, Michael et al.

Ingår i Molecular Imaging and Biology, s. 241-249, 2021

• DOI för In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1

Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination

Volk, Anna-Luisa; Mebrahtu, Aman; Ko, Bong-Kook; Lundqvist, Magnus et al.

Ingår i Drugs in R&D, s. 157-168, 2021

• DOI för Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination
• Ladda ner fulltext (pdf) av Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination

Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer

Alhuseinalkhudhur, Ali; Lubberink, Mark; Lindman, Henrik; Tolmachev, Vladimir et al.

Ingår i EJNMMI Research, 2020

• DOI för Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer
• Ladda ner fulltext (pdf) av Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer

Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Garousi, Javad; Orlova, Anna; Frejd, Fredrik Y.; Tolmachev, Vladimir

Ingår i EJNMMI Radiopharmacy and Chemistry, 2020

• DOI för Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

Garousi, Javad; Huizing, Fokko J.; Vorobyeva, Anzhelika; Mitran, Bogdan et al.

Ingår i Scientific Reports, 2019

• DOI för Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts
• Ladda ner fulltext (pdf) av Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models

Huizing, Fokko J.; Garousi, Javad; Lok, Jasper; Franssen, Gerben et al.

Ingår i Scientific Reports, 2019

• DOI för CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models
• Ladda ner fulltext (pdf) av CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models

Diagnostic HER2-binding radiopharmaceutical, [Ga-68]Ga-ABY-025, for routine clinical use in breast cancer patients

Velikyan, Irina; Schweighoefer, Philip; Feldwisch, Joachim; Seemann, Johanna et al.

Ingår i American Journal of Nuclear Medicine and Molecular Imaging, s. 12-23, 2019

Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab

Orlova, Anna; Bass, Tarek Z.; Rinne, Sara S.; Leitao, Charles Dahlsson et al.

Ingår i Molecular Pharmaceutics, s. 3394-3403, 2018

• DOI för Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab

Kinetic Analysis of the HER2-binding ABY-025 Affibody Using Dynamic PET in Patients with Metastatic Breast Cancer

Alhuseinalkhudhur, Ali; Lubberink, Mark; Velikyan, Irina; Tolmachev, Vladimir et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018

Same-day imaging using small proteins: Clinical experience and translational prospects in oncology.

Krasniqi, Ahmet; D'Huyvetter, Matthias; Devoogdt, Nick; Frejd, Fredrik Y. et al.

Ingår i Journal of Nuclear Medicine, s. 885-891, 2018

• DOI för Same-day imaging using small proteins: Clinical experience and translational prospects in oncology.

In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin- binding therapeutic affibody construct

Bass, Tarek Z.; Rosestedt, Maria; Mitran, Bogdan; Frejd, Fredrik Y. et al.

Ingår i Scientific Reports, 2017

• DOI för In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin- binding therapeutic affibody construct
• Ladda ner fulltext (pdf) av In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin- binding therapeutic affibody construct

In Vivo Imaging of the Programmed Death Ligand 1 by F-18 PET

Trotter, Dinko E. Gonzalez; Meng, Xiangjun; McQuade, Paul; Rubins, Daniel et al.

Ingår i Journal of Nuclear Medicine, s. 1852-1857, 2017

• DOI för In Vivo Imaging of the Programmed Death Ligand 1 by F-18 PET

Comparative evaluation of Affibody molecules for radionuclide imaging of in vivo expression of carbonic anhydrase IX

Garousi, Javad; Honarvar, Hadis; Andersson, Ken G.; Mitran, Bogdan et al.

Ingår i Molecular Pharmaceutics, s. 3676-3687, 2016

• DOI för Comparative evaluation of Affibody molecules for radionuclide imaging of in vivo expression of carbonic anhydrase IX

Evaluation of Affibody Molecules for Radionuclide Imaging of Carbonic Abhydrase IX Expression In Vivo

Garousi, Javad; Honarvar, Hadis; Andersson, K.; Mitran, Bogdan et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2016

In vivo evaluation of pharmacokinetics, tumors targeting and therapeutic efficacy of a novel format of HER3-targeting affibody molecule with prolonged blood circulation

Orlova, Anna; Rosestedt, Maria; Mitran, Bogdan; Bass, T. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2016

Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-ZCAIX: 1 Affibody molecule

Honarvar, Hadis; Garousi, Javad; Gunneriusson, Elin; Höidén-Guthenberg, Ingmarie et al.

Ingår i International Journal of Oncology, s. 513-20, 2015

• DOI för Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-ZCAIX: 1 Affibody molecule
• Ladda ner fulltext (pdf) av Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-ZCAIX: 1 Affibody molecule

Target-specific cytotoxic effects on HER2-expressing cells by the tripartite fusion toxin Z(HER2:2891)-ABD-PE38X8, including a targeting affibody molecule and a half-life extension domain

Liu, Hao; Seijsing, Johan; Frejd, Fredrik Y.; Tolmachev, Vladimir et al.

Ingår i International Journal of Oncology, s. 601-609, 2015

• DOI för Target-specific cytotoxic effects on HER2-expressing cells by the tripartite fusion toxin Z(HER2:2891)-ABD-PE38X8, including a targeting affibody molecule and a half-life extension domain

Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension

Malm, Magdalena; Bass, Tarek; Gudmundsdotter, Lindvi; Lord, Martin et al.

Ingår i Biotechnology Journal, s. 1215-1222, 2014

• DOI för Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension

Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity

Fleetwood, Filippa; Klint, Susanne; Hanze, Martin; Gunneriusson, Elin et al.

Ingår i Scientific Reports, s. 7518, 2014

• DOI för Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity
• Ladda ner fulltext (pdf) av Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity

Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Hosseinimehr, Seyed Jalal et al.

Ingår i Journal of Nuclear Medicine, s. 294-300, 2014

• DOI för Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591
• Ladda ner fulltext (pdf) av Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591

An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Seijsing, Johan; Lindborg, Malin; Hoiden-Guthenberg, Ingmarie; Bonisch, Heiko et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 17110-17115, 2014

• DOI för An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-Z09781 Affibody molecule

Honarvar, Hadis; Garousi, Javad; Gunneriusson, E.; Hoiden-Guthenberg, I. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014

Simultaneous dual-radionuclide SPECT-imaging of HER2 expression using 99mTc-Affibody/111In-trastuzumab

Ahlstedt, J.; Orbom, A.; Akesson, A.; Frejd, Fredrik et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014

Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification

Malm, Magdalena; Kronqvist, Nina; Lindberg, Hanna; Gudmundsdotter, Lindvi et al.

Ingår i PLOS ONE, 2013

• DOI för Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification
• Ladda ner fulltext (pdf) av Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification

Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein

Orlova, Anna; Jonsson, Andreas; Rosik, Daniel; Lundqvist, Hans et al.

Ingår i Journal of Nuclear Medicine, s. 961-968, 2013

• DOI för Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein
• Ladda ner fulltext (pdf) av Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein

Imaging of PDGFRbeta expression in vivo using Affibody molecule In-111-DOTA-Z09591

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Hosseinimehr, S. Jalal et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2013

In vivo imaging of PDGFR beta expression using In-111-DOTA-Z09591 Affibody molecule

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Eriksson, Olof et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, 2013

Generation and Evaluation of Bispecific Affibody Molecules for Simultaneous Targeting of EGFR and HER2

Ekerljung, Lina; Wållberg, Helena; Sohrabian, Azita; Andersson, Karl et al.

Ingår i Bioconjugate chemistry, s. 1802-1811, 2012

• DOI för Generation and Evaluation of Bispecific Affibody Molecules for Simultaneous Targeting of EGFR and HER2

Cellular effects of HER3-specific affibody molecules

Göstring, Lovisa; Malm, Magdalena; Höidén-Guthenberg, Ingmarie; Frejd, Fredrik et al.

Ingår i PLOS ONE, 2012

• DOI för Cellular effects of HER3-specific affibody molecules
• Ladda ner fulltext (pdf) av Cellular effects of HER3-specific affibody molecules

Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor beta In Vivo

Lindborg, M.; Cortez, E.; Höiden-Guthenberg, I.; Gunneriusson, E. et al.

Ingår i Journal of Molecular Biology, s. 298-315, 2011

• DOI för Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor beta In Vivo

Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules

Kronqvist, Nina; Malm, Magdalena; Göstring, Lovisa; Gunneriusson, Elin et al.

Ingår i Protein Engineering Design & Selection, s. 385-396, 2011

• DOI för Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules

Non-immunoglobulin based protein scaffolds

Löfblom, John; Frejd, Fredrik Y; Ståhl, Stefan

Ingår i Current Opinion in Biotechnology, s. 843-848, 2011

• DOI för Non-immunoglobulin based protein scaffolds

Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

Göstring, Lovisa; Chew, Ming Tsuey; Orlova, Anna; Höidén-Guthenberg, Ingmarie et al.

Ingår i International Journal of Oncology, s. 757-763, 2010

• DOI för Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

Targeting of Epidermal Growth Factor Receptor (EGFR)-Expressing Tumor Cells with Sterically Stabilized Affibody Liposomes (SAL)

Beuttler, Julia; Rothdiener, Miriam; Mueller, Dafne; Frejd, Fredrik Y. et al.

Ingår i Bioconjugate chemistry, s. 1201-1208, 2009

• DOI för Targeting of Epidermal Growth Factor Receptor (EGFR)-Expressing Tumor Cells with Sterically Stabilized Affibody Liposomes (SAL)

Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding

Tolmachev, Vladimir; Mume, Eskender; Sjöberg, Stefan; Frejd, Fredrik Y. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 692-701, 2009

• DOI för Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding

Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule

Friedman, Mikaela; Lindstrom, Sara; Ekerljung, Lina; Andersson-Svahn, Helene et al.

Ingår i Biotechnology and applied biochemistry, s. 121-131, 2009

• DOI för Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule

Generation of tumour-necrosis-factor-alpha-specific affibody molecules capable of blocking receptor binding in vitro

Jonsson, Andreas; Wallberg, Helena; Herne, Nina; Ståhl, Stefan et al.

Ingår i Biotechnology and applied biochemistry, s. 93-103, 2009

• DOI för Generation of tumour-necrosis-factor-alpha-specific affibody molecules capable of blocking receptor binding in vitro

Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy

Eissler, Nina; Altena, Renske; Alhuseinalkhudhur, Ali; Bragina, Olga et al.

Ingår i Biomedicines, 2024

• DOI för Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy
• Ladda ner fulltext (pdf) av Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy

Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications

Altena, Renske; Tzortzakakis, Antonios; Buren, Siri Af; Tran, Thuy A. et al.

Ingår i EJNMMI Research, 2023

• DOI för Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications
• Ladda ner fulltext (pdf) av Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications

HER2-låg bröstcancer ny entitet: ökar behandlingsmöjligheterna

Altena, Renske; Tzortzakakis, Antonios; Sörensen, Jens; Frejd, Fredrik Y. et al.

Ingår i Läkartidningen, 2022

Affibody molecules as engineered protein drugs

Frejd, Fredrik Y.; Kim, Kyu-Tae

Ingår i Experimental and Molecular Medicine, 2017

• DOI för Affibody molecules as engineered protein drugs
• Ladda ner fulltext (pdf) av Affibody molecules as engineered protein drugs

Affibody Molecules in Biotechnological and Medical Applications

Ståhl, Stefan; Gräslund, Torbjörn; Karlström, Amelie Eriksson; Frejd, Fredrik Y. et al.

Ingår i Trends in Biotechnology, s. 691-712, 2017

• DOI för Affibody Molecules in Biotechnological and Medical Applications

Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds

Malm, Magdalena; Frejd, Fredrik Y.; Ståhl, Stefan; Löfblom, John

Ingår i mAbs, s. 1195-1209, 2016

• DOI för Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds

Non-immunoglobulin based protein scaffolds

Löfblom, John; Frejd, Fredrik Y.; Ståhl, Stefan

Ingår i Current Opinion in Biotechnology, s. 843-848, 2011

• DOI för Non-immunoglobulin based protein scaffolds

Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications

Löfblom, John; Feldwisch, Joachim; Tolmachev, Vladimir; Carlsson, Jörgen et al.

Ingår i FEBS Letters, s. 2670-2680, 2010

• DOI för Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications