Fredrik Frejd

Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Tolmachev, Vladimir M.; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A.; Rosly, Alia Hani et al.

Ingår i ACS Pharmacology & Translational Science, s. 706-717, 2025

• DOI för Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules
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Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Mortensen, Anja; Berglund, Hanna; Jha, Preeti; Stenman, Adam et al.

Ingår i Molecular Cancer Therapeutics, s. 753-762, 2025

• DOI för Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
• Ladda ner fulltext (pdf) av Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Lundgren Mortensen, Anja Charlotte; Hofström, Camilla; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear Medicine and Biology, 2025

• DOI för Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy
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Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Wegrzyniak, Olivia; Lechi, Francesco; Mitran, Bogdan; Cheung, Pierre et al.

Ingår i iScience, 2024

• DOI för Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
• Ladda ner fulltext (pdf) av Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA

Lechi, Francesco; Eriksson, Jonas; Odell, Luke R.; Wegrzyniak, Olivia et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
• Ladda ner fulltext (pdf) av Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA

Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Tolmachev, Vladimir M.; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A.; Rosly, Alia Hani et al.

Ingår i ACS Pharmacology & Translational Science, s. 706-717, 2025

• DOI för Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules
• Ladda ner fulltext (pdf) av Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Mortensen, Anja; Berglund, Hanna; Jha, Preeti; Stenman, Adam et al.

Ingår i Molecular Cancer Therapeutics, s. 753-762, 2025

• DOI för Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
• Ladda ner fulltext (pdf) av Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Lundgren Mortensen, Anja Charlotte; Hofström, Camilla; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear Medicine and Biology, 2025

• DOI för Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy
• Ladda ner fulltext (pdf) av Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Wegrzyniak, Olivia; Lechi, Francesco; Mitran, Bogdan; Cheung, Pierre et al.

Ingår i iScience, 2024

• DOI för Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
• Ladda ner fulltext (pdf) av Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA

Lechi, Francesco; Eriksson, Jonas; Odell, Luke R.; Wegrzyniak, Olivia et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
• Ladda ner fulltext (pdf) av Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA

Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation

Oroujeni, Maryam; Carlqvist, Matilda; Ryer, Eva; Orlova, Anna et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation
• Ladda ner fulltext (pdf) av Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation

Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile

Liu, Yongsheng; Oroujeni, Maryam; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 4038-4048, 2024

• DOI för Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile
• Ladda ner fulltext (pdf) av Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile

Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [ ⁶⁸ Ga]Ga-ABY-025: Results from a Pilot Study

Altena, Renske; af Buren, Siri; Blomgren, August; Karlsson, Emelie et al.

Ingår i Journal of Nuclear Medicine, s. 700-707, 2024

• DOI för Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [ ⁶⁸ Ga]Ga-ABY-025: Results from a Pilot Study

Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

Liu, Yongsheng; Xu, Tianqi; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Ingår i Cancers, 2023

• DOI för Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab
• Ladda ner fulltext (pdf) av Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis

Klint, Susanne; Feldwisch, Joachim; Gudmundsdotter, Lindvi; Bergstedt, Karin Dillner et al.

Ingår i mAbs, 2023

• DOI för Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis
• Ladda ner fulltext (pdf) av Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis

Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy

Mortensen, Anja; Berglund, Hanna; Segerström, Lova; Walle, M. et al.

Ingår i Scientific Reports, 2023

• DOI för Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy
• Ladda ner fulltext (pdf) av Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy

Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Ingår i Nuclear Medicine and Biology, 2023

• DOI för Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3
• Ladda ner fulltext (pdf) av Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II, randomized, placebo-controlled, double-blind, dose-finding multicentre study including long-term treatment

Gerdes, Sascha; Staubach, Petra; Dirschka, Thomas; Wetzel, Dieter et al.

Ingår i British Journal of Dermatology, s. 381-391, 2023

• DOI för Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II, randomized, placebo-controlled, double-blind, dose-finding multicentre study including long-term treatment
• Ladda ner fulltext (pdf) av Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II, randomized, placebo-controlled, double-blind, dose-finding multicentre study including long-term treatment

Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Wegrzyniak, Olivia; Zhang, Bo; Rokka, Johanna; Rosestedt, Maria et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2023

• DOI för Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β
• Ladda ner fulltext (pdf) av Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts

Mohajershojai, Tabassom; Spangler, Douglas; Chopra, Saloni; Frejd, Fredrik Y. et al.

Ingår i Cancers, 2023

• DOI för Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts
• Ladda ner fulltext (pdf) av Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts

Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer

Bragina, Olga; Chernov, Vladimir; Larkina, Mariia; Rybina, Anstasiya et al.

Ingår i Theranostics, s. 4858-4871, 2023

• DOI för Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer
• Ladda ner fulltext (pdf) av Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer

Human Epidermal Growth Factor Receptor 2-Targeting [⁶⁸Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.

Alhuseinalkhudhur, Ali; Lindman, Henrik; Liss, Per; Sundin, Tora et al.

Ingår i Journal of Nuclear Medicine, s. 1364-1370, 2023

• DOI för Human Epidermal Growth Factor Receptor 2-Targeting [⁶⁸Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.
• Ladda ner fulltext (pdf) av Human Epidermal Growth Factor Receptor 2-Targeting [⁶⁸Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.

Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Ingår i Pharmaceutics, 2022

• DOI för Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3
• Ladda ner fulltext (pdf) av Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Liu, Yongsheng; Gueler, Rezan; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Ingår i Pharmaceutics, 2022

• DOI för Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis
• Ladda ner fulltext (pdf) av Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071

Liu, Yongsheng; Vorobyeva, Anzhelika; Orlova, Anna; Konijnenberg, Mark W. et al.

Ingår i Pharmaceutics, 2022

• DOI för Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071
• Ladda ner fulltext (pdf) av Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071

In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer

Mohajershojai, Tabassom; Jha, Preeti; Bostroem, Anna; Frejd, Fredrik Y. et al.

Ingår i Frontiers in Oncology, 2022

• DOI för In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer
• Ladda ner fulltext (pdf) av In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer

Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Liu, Yongsheng; Vorobyeva, Anzhelika; Xu, Tianqi; Orlova, Anna et al.

Ingår i Pharmaceutics, 2021

• DOI för Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain
• Ladda ner fulltext (pdf) av Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination

Volk, Anna-Luisa; Mebrahtu, Aman; Ko, Bong-Kook; Lundqvist, Magnus et al.

Ingår i Drugs in R&D, s. 157-168, 2021

• DOI för Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination
• Ladda ner fulltext (pdf) av Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination

Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Oroujeni, Maryam; Rinne, Sara S.; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake
• Ladda ner fulltext (pdf) av Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1

Rubins, Daniel J.; Meng, Xiangjun; McQuade, Paul; Klimas, Michael et al.

Ingår i Molecular Imaging and Biology, s. 241-249, 2021

• DOI för In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1

Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer

Alhuseinalkhudhur, Ali; Lubberink, Mark; Lindman, Henrik; Tolmachev, Vladimir et al.

Ingår i EJNMMI Research, 2020

• DOI för Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer
• Ladda ner fulltext (pdf) av Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer

Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Garousi, Javad; Orlova, Anna; Frejd, Fredrik Y.; Tolmachev, Vladimir

Ingår i EJNMMI Radiopharmacy and Chemistry, 2020

• DOI för Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

Garousi, Javad; Huizing, Fokko J.; Vorobyeva, Anzhelika; Mitran, Bogdan et al.

Ingår i Scientific Reports, 2019

• DOI för Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts
• Ladda ner fulltext (pdf) av Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models

Huizing, Fokko J.; Garousi, Javad; Lok, Jasper; Franssen, Gerben et al.

Ingår i Scientific Reports, 2019

• DOI för CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models
• Ladda ner fulltext (pdf) av CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models

Diagnostic HER2-binding radiopharmaceutical, [Ga-68]Ga-ABY-025, for routine clinical use in breast cancer patients

Velikyan, Irina; Schweighoefer, Philip; Feldwisch, Joachim; Seemann, Johanna et al.

Ingår i American Journal of Nuclear Medicine and Molecular Imaging, s. 12-23, 2019

Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab

Orlova, Anna; Bass, Tarek Z.; Rinne, Sara S.; Leitao, Charles Dahlsson et al.

Ingår i Molecular Pharmaceutics, s. 3394-3403, 2018

• DOI för Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab

Kinetic Analysis of the HER2-binding ABY-025 Affibody Using Dynamic PET in Patients with Metastatic Breast Cancer

Alhuseinalkhudhur, Ali; Lubberink, Mark; Velikyan, Irina; Tolmachev, Vladimir et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018

Same-day imaging using small proteins: Clinical experience and translational prospects in oncology.

Krasniqi, Ahmet; D'Huyvetter, Matthias; Devoogdt, Nick; Frejd, Fredrik Y. et al.

Ingår i Journal of Nuclear Medicine, s. 885-891, 2018

• DOI för Same-day imaging using small proteins: Clinical experience and translational prospects in oncology.

In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin- binding therapeutic affibody construct

Bass, Tarek Z.; Rosestedt, Maria; Mitran, Bogdan; Frejd, Fredrik Y. et al.

Ingår i Scientific Reports, 2017

• DOI för In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin- binding therapeutic affibody construct
• Ladda ner fulltext (pdf) av In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin- binding therapeutic affibody construct

In Vivo Imaging of the Programmed Death Ligand 1 by F-18 PET

Trotter, Dinko E. Gonzalez; Meng, Xiangjun; McQuade, Paul; Rubins, Daniel et al.

Ingår i Journal of Nuclear Medicine, s. 1852-1857, 2017

• DOI för In Vivo Imaging of the Programmed Death Ligand 1 by F-18 PET

Comparative evaluation of Affibody molecules for radionuclide imaging of in vivo expression of carbonic anhydrase IX

Garousi, Javad; Honarvar, Hadis; Andersson, Ken G.; Mitran, Bogdan et al.

Ingår i Molecular Pharmaceutics, s. 3676-3687, 2016

• DOI för Comparative evaluation of Affibody molecules for radionuclide imaging of in vivo expression of carbonic anhydrase IX

In vivo evaluation of pharmacokinetics, tumors targeting and therapeutic efficacy of a novel format of HER3-targeting affibody molecule with prolonged blood circulation

Orlova, Anna; Rosestedt, Maria; Mitran, Bogdan; Bass, T. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2016

Evaluation of Affibody Molecules for Radionuclide Imaging of Carbonic Abhydrase IX Expression In Vivo

Garousi, Javad; Honarvar, Hadis; Andersson, K.; Mitran, Bogdan et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2016

Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-ZCAIX: 1 Affibody molecule

Honarvar, Hadis; Garousi, Javad; Gunneriusson, Elin; Höidén-Guthenberg, Ingmarie et al.

Ingår i International Journal of Oncology, s. 513-20, 2015

• DOI för Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-ZCAIX: 1 Affibody molecule
• Ladda ner fulltext (pdf) av Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-ZCAIX: 1 Affibody molecule

Target-specific cytotoxic effects on HER2-expressing cells by the tripartite fusion toxin Z(HER2:2891)-ABD-PE38X8, including a targeting affibody molecule and a half-life extension domain

Liu, Hao; Seijsing, Johan; Frejd, Fredrik Y.; Tolmachev, Vladimir et al.

Ingår i International Journal of Oncology, s. 601-609, 2015

• DOI för Target-specific cytotoxic effects on HER2-expressing cells by the tripartite fusion toxin Z(HER2:2891)-ABD-PE38X8, including a targeting affibody molecule and a half-life extension domain

Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension

Malm, Magdalena; Bass, Tarek; Gudmundsdotter, Lindvi; Lord, Martin et al.

Ingår i Biotechnology Journal, s. 1215-1222, 2014

• DOI för Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension

Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity

Fleetwood, Filippa; Klint, Susanne; Hanze, Martin; Gunneriusson, Elin et al.

Ingår i Scientific Reports, s. 7518, 2014

• DOI för Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity
• Ladda ner fulltext (pdf) av Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity

Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Hosseinimehr, Seyed Jalal et al.

Ingår i Journal of Nuclear Medicine, s. 294-300, 2014

• DOI för Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591
• Ladda ner fulltext (pdf) av Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591

An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Seijsing, Johan; Lindborg, Malin; Hoiden-Guthenberg, Ingmarie; Bonisch, Heiko et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 17110-17115, 2014

• DOI för An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Simultaneous dual-radionuclide SPECT-imaging of HER2 expression using 99mTc-Affibody/111In-trastuzumab

Ahlstedt, J.; Orbom, A.; Akesson, A.; Frejd, Fredrik et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014

Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-Z09781 Affibody molecule

Honarvar, Hadis; Garousi, Javad; Gunneriusson, E.; Hoiden-Guthenberg, I. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014

Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification

Malm, Magdalena; Kronqvist, Nina; Lindberg, Hanna; Gudmundsdotter, Lindvi et al.

Ingår i PLOS ONE, 2013

• DOI för Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification
• Ladda ner fulltext (pdf) av Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification

Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein

Orlova, Anna; Jonsson, Andreas; Rosik, Daniel; Lundqvist, Hans et al.

Ingår i Journal of Nuclear Medicine, s. 961-968, 2013

• DOI för Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein
• Ladda ner fulltext (pdf) av Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein

Imaging of PDGFRbeta expression in vivo using Affibody molecule In-111-DOTA-Z09591

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Hosseinimehr, S. Jalal et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2013

In vivo imaging of PDGFR beta expression using In-111-DOTA-Z09591 Affibody molecule

Tolmachev, Vladimir; Varasteh, Zohreh; Honarvar, Hadis; Eriksson, Olof et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, 2013

Generation and Evaluation of Bispecific Affibody Molecules for Simultaneous Targeting of EGFR and HER2

Ekerljung, Lina; Wållberg, Helena; Sohrabian, Azita; Andersson, Karl et al.

Ingår i Bioconjugate chemistry, s. 1802-1811, 2012

• DOI för Generation and Evaluation of Bispecific Affibody Molecules for Simultaneous Targeting of EGFR and HER2

Cellular effects of HER3-specific affibody molecules

Göstring, Lovisa; Malm, Magdalena; Höidén-Guthenberg, Ingmarie; Frejd, Fredrik et al.

Ingår i PLOS ONE, 2012

• DOI för Cellular effects of HER3-specific affibody molecules
• Ladda ner fulltext (pdf) av Cellular effects of HER3-specific affibody molecules

Non-immunoglobulin based protein scaffolds

Löfblom, John; Frejd, Fredrik Y; Ståhl, Stefan

Ingår i Current Opinion in Biotechnology, s. 843-848, 2011

• DOI för Non-immunoglobulin based protein scaffolds

Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules

Kronqvist, Nina; Malm, Magdalena; Göstring, Lovisa; Gunneriusson, Elin et al.

Ingår i Protein Engineering Design & Selection, s. 385-396, 2011

• DOI för Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules

Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor beta In Vivo

Lindborg, M.; Cortez, E.; Höiden-Guthenberg, I.; Gunneriusson, E. et al.

Ingår i Journal of Molecular Biology, s. 298-315, 2011

• DOI för Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor beta In Vivo

Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

Göstring, Lovisa; Chew, Ming Tsuey; Orlova, Anna; Höidén-Guthenberg, Ingmarie et al.

Ingår i International Journal of Oncology, s. 757-763, 2010

• DOI för Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

Targeting of Epidermal Growth Factor Receptor (EGFR)-Expressing Tumor Cells with Sterically Stabilized Affibody Liposomes (SAL)

Beuttler, Julia; Rothdiener, Miriam; Mueller, Dafne; Frejd, Fredrik Y. et al.

Ingår i Bioconjugate chemistry, s. 1201-1208, 2009

• DOI för Targeting of Epidermal Growth Factor Receptor (EGFR)-Expressing Tumor Cells with Sterically Stabilized Affibody Liposomes (SAL)

Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding

Tolmachev, Vladimir; Mume, Eskender; Sjöberg, Stefan; Frejd, Fredrik Y. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 692-701, 2009

• DOI för Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding

Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule

Friedman, Mikaela; Lindstrom, Sara; Ekerljung, Lina; Andersson-Svahn, Helene et al.

Ingår i Biotechnology and applied biochemistry, s. 121-131, 2009

• DOI för Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule

Generation of tumour-necrosis-factor-alpha-specific affibody molecules capable of blocking receptor binding in vitro

Jonsson, Andreas; Wallberg, Helena; Herne, Nina; Ståhl, Stefan et al.

Ingår i Biotechnology and applied biochemistry, s. 93-103, 2009

• DOI för Generation of tumour-necrosis-factor-alpha-specific affibody molecules capable of blocking receptor binding in vitro

Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy

Eissler, Nina; Altena, Renske; Alhuseinalkhudhur, Ali; Bragina, Olga et al.

Ingår i Biomedicines, 2024

• DOI för Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy
• Ladda ner fulltext (pdf) av Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy

Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications

Altena, Renske; Tzortzakakis, Antonios; Buren, Siri Af; Tran, Thuy A. et al.

Ingår i EJNMMI Research, 2023

• DOI för Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications
• Ladda ner fulltext (pdf) av Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications

HER2-låg bröstcancer ny entitet: ökar behandlingsmöjligheterna

Altena, Renske; Tzortzakakis, Antonios; Sörensen, Jens; Frejd, Fredrik Y. et al.

Ingår i Läkartidningen, 2022

Affibody molecules as engineered protein drugs

Frejd, Fredrik Y.; Kim, Kyu-Tae

Ingår i Experimental and Molecular Medicine, 2017

• DOI för Affibody molecules as engineered protein drugs
• Ladda ner fulltext (pdf) av Affibody molecules as engineered protein drugs

Affibody Molecules in Biotechnological and Medical Applications

Ståhl, Stefan; Gräslund, Torbjörn; Karlström, Amelie Eriksson; Frejd, Fredrik Y. et al.

Ingår i Trends in Biotechnology, s. 691-712, 2017

• DOI för Affibody Molecules in Biotechnological and Medical Applications

Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds

Malm, Magdalena; Frejd, Fredrik Y.; Ståhl, Stefan; Löfblom, John

Ingår i mAbs, s. 1195-1209, 2016

• DOI för Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds

Non-immunoglobulin based protein scaffolds

Löfblom, John; Frejd, Fredrik Y.; Ståhl, Stefan

Ingår i Current Opinion in Biotechnology, s. 843-848, 2011

• DOI för Non-immunoglobulin based protein scaffolds

Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications

Löfblom, John; Feldwisch, Joachim; Tolmachev, Vladimir; Carlsson, Jörgen et al.

Ingår i FEBS Letters, s. 2670-2680, 2010

• DOI för Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications