Diana Spiegelberg

Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy

Uffenorde, Julia; Hariri, Mehran; Papalanis, Eleftherios; Staffas, Annika et al.

Part of Frontiers in Oncology, 2025

• DOI for Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
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Copper-cysteamine nanoparticles in cancer treatment: a systematic review

Ejtema, Mahsa; Chegeni, Nahid; Langen, Britta; Marallu, Mousa Ahmadi et al.

Part of Cell Biology and Toxicology, 2025

• DOI for Copper-cysteamine nanoparticles in cancer treatment: a systematic review
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Ascorbate induces G2/M arrest and necrosis without  generation of direct DNA double-strand breaks

Hariri, Mehran; Papalanis, Eleftherios; Spiegelberg, Diana; Plotnikov, Evgenii et al.

Part of Heliyon, 2025

• DOI for Ascorbate induces G2/M arrest and necrosis without  generation of direct DNA double-strand breaks
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Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry

Ingelshed, Katrine; Melssen, Marit M.; Spiegelberg, Diana

Part of STAR Protocols, 2025

• DOI for Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry
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In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup

Sokol, Olga; Frederiksen, Anders Tobias; Sitarz, Mateusz; Sørensen, Brita Singers et al.

Part of Clinical and Translational Radiation Oncology, 2025

• DOI for In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup
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Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy

Uffenorde, Julia; Hariri, Mehran; Papalanis, Eleftherios; Staffas, Annika et al.

Part of Frontiers in Oncology, 2025

• DOI for Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
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Ascorbate induces G2/M arrest and necrosis without  generation of direct DNA double-strand breaks

Hariri, Mehran; Papalanis, Eleftherios; Spiegelberg, Diana; Plotnikov, Evgenii et al.

Part of Heliyon, 2025

• DOI for Ascorbate induces G2/M arrest and necrosis without  generation of direct DNA double-strand breaks
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Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry

Ingelshed, Katrine; Melssen, Marit M.; Spiegelberg, Diana

Part of STAR Protocols, 2025

• DOI for Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry
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In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup

Sokol, Olga; Frederiksen, Anders Tobias; Sitarz, Mateusz; Sørensen, Brita Singers et al.

Part of Clinical and Translational Radiation Oncology, 2025

• DOI for In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup
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Targeting mutant p53: Evaluation of novel anti-p53^R175H monoclonal antibodies as diagnostic tools

Spiegelberg, Diana; Hwang, Le-Ann; Pua, Khian Hong; Kumar, Sashwini Chandra et al.

Part of Scientific Reports, 2025

• DOI for Targeting mutant p53: Evaluation of novel anti-p53^R175H monoclonal antibodies as diagnostic tools
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MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors

Ingelshed, Katrine; Melssen, Marit M.; Kannan, Pavitra; Chandramohan, Arun et al.

Part of iScience, 2024

• DOI for MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
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Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists

Chandramohan, Arun; Josien, Hubert; Yuen, Tsz Ying; Duggal, Ruchia et al.

Part of Nature Communications, 2024

• DOI for Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
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Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas

Mortensen, Anja; Imgenberg-Kreuz, Juliana; Spiegelberg, Diana; Botling, J. et al.

Part of Heliyon, 2023

• DOI for Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas
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Combination therapy of tyrosine kinase inhibitor sorafenib with the HSP90 inhibitor onalespib as a novel treatment regimen for thyroid cancer

Lundgren Mortensen, Anja Charlotte; Berglund, Hanna; Hariri, Mehran; Papalanis, Eleftherios et al.

Part of Scientific Reports, 2023

• DOI for Combination therapy of tyrosine kinase inhibitor sorafenib with the HSP90 inhibitor onalespib as a novel treatment regimen for thyroid cancer
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Ra-223 induces clustered DNA damage and inhibits cell survival in several prostate cancer cell lines

Abramenkovs, Andris; Hariri, Mehran; Spiegelberg, Diana; Nilsson, Sten et al.

Part of Translational Oncology, 2022

• DOI for Ra-223 induces clustered DNA damage and inhibits cell survival in several prostate cancer cell lines
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Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy

Yu Koh, Xin; Koh, Xiao Hui; Spiegelberg, Diana; Jha, Preeti et al.

Part of Scientific Reports, 2022

• DOI for Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy
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The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy

Ingelshed, Katrine; Spiegelberg, Diana; Kannan, Pavitra; Påvénius, Linnéa et al.

Part of Cancer Research Communications, p. 1075-1088, 2022

• DOI for The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
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Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein

Spiegelberg, Diana; Malmberg, Christer; Ehrsson, Ylva Tiblom; Laurell, Göran

Part of Cancers, 2022

• DOI for Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein
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K-D determination from time-resolved experiments on live cells with LigandTracer and reconciliation with end-point flow cytometry measurements

Spiegelberg, Diana; Stenberg, Jonas; Richalet, Pascale; Vanhove, Marc

Part of European Biophysics Journal, p. 979-991, 2021

• DOI for K-D determination from time-resolved experiments on live cells with LigandTracer and reconciliation with end-point flow cytometry measurements
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Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib

Mortensen, Anja; Mohajershojai, Tabassom; Hariri, Mehran; Pettersson, Marika et al.

Part of Frontiers in Oncology, 2020

• DOI for Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib
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The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model

Spiegelberg, Diana; Lundgren Mortensen, Anja Charlotte; Palupi, Kartika Dyah; Micke, Patrick et al.

Part of Frontiers in Oncology, 2020

• DOI for The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model
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The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach

Spiegelberg, Diana; Abramenkovs, Andris; Mortensen, Anja; Lundsten, Sara et al.

Part of Scientific Reports, 2020

• DOI for The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach
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The radiosensitizer Onalespib increases complete remission in Lu-177-DOTATATE-treated mice bearing neuroendocrine tumor xenografts

Lundsten, Sara; Spiegelberg, Diana; Raval, Nakul; Nestor, Marika

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 980-990, 2020

• DOI for The radiosensitizer Onalespib increases complete remission in Lu-177-DOTATATE-treated mice bearing neuroendocrine tumor xenografts
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The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells

Lundgren Mortensen, Anja; Spiegelberg, Diana; Brown, Christopher John; Lane, David Philip et al.

Part of Frontiers in Oncology, 2019

• DOI for The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells
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The HSP90 inhibitor onalespib potentiates Lu-177-DOTATATE therapy in neuroendocrine tumor cells

Lundsten, Sara; Spiegelberg, Diana; Stenerlöw, Bo; Nestor, Marika

Part of International Journal of Oncology, p. 1287-1295, 2019

• DOI for The HSP90 inhibitor onalespib potentiates Lu-177-DOTATATE therapy in neuroendocrine tumor cells
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Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy

Mortensen, Anja; Spiegelberg, Diana; Haylock, Anna-Karin; Lundqvist, Hans et al.

Part of International Journal of Oncology, p. 1875-1885, 2018

• DOI for Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy
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Ra223 induced clustered DNA damage reduces cell survival independently of androgen receptor variant 7 expression

Abramenkovs, Andris; Spiegelberg, Diana; Stenerlöw, Bo

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

First in vivo study of the MDM2/MDMX-p53 antagonist PM2 as potentiator of external radiotherapy in wt p53 cancer

Spiegelberg, Diana; Mortensen, Anja C.; Lundsten, Sara; Brown, C. J. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for First in vivo study of the MDM2/MDMX-p53 antagonist PM2 as potentiator of external radiotherapy in wt p53 cancer

Potentiating Lu-177-DOTATATE Therapy By HSP90 Inhibition - First In Vivo Study

Lundsten, Sara; Spiegelberg, Diana; Raval, Nakul; Stenerlöw, Bo et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors

Spiegelberg, Diana; Mortensen, Anja; Lundsten, Sara; Brown, Christopher J. et al.

Part of Cancer Research, p. 5084-5093, 2018

• DOI for The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors

Radioiodination Of Small Stapled Peptides For p53 Therapy

Lundsten, Sara; Spiegelberg, Diana; Agmo Hernández, Víctor; Brown, C. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

In Vivo Assessment of p53 Therapy as a Way of Enhancing Therapeutic Effects of Radiation

Mortensen, Anja C.; Spiegelberg, Diana; Lundsten, Sara; Brown, C. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

The Novel, Stapled HDM2/HDMX-p53 Antagonist PM2 Has Potent Antitumorigenic Activities and Enhances the Effects of External Radiotherapy

Mortensen, Anja C.; Spiegelberg, Diana; Brown, C.; Lane, D. P. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

The HSP90-inhibitor Onalespib Potentiates Lu-177-Dotatate Treatment of Neuroendocrine Tumors

Lundsten, Sara; Mortensen, Anja; Makiniemi, A.; Spiegelberg, Diana et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

In Vitro and In Vivo Growth Inhibitory and Radiosensitizing Effects of the Anti-HSP90 agent Onalespib

Spiegelberg, Diana; Lundsten, Sara; Mortensen, Anja C.; Abramenkovs, Andris et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

HSP90 inhibition in angiosarcoma

Spiegelberg, Diana

Part of British Journal of Dermatology, p. 343-344, 2017

• DOI for HSP90 inhibition in angiosarcoma

A real-time in vitro assay as a potential predictor of in vivo tumor imaging properties

Spiegelberg, Diana; Stenberg, Jonas; Haylock, Anna-Karin; Nestor, Marika

Part of Nuclear Medicine and Biology, p. 12-18, 2016

• DOI for A real-time in vitro assay as a potential predictor of in vivo tumor imaging properties

Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma

Haylock, Anna-Karin; Spiegelberg, Diana; Mortensen, Anja C.; Selvaraju, Ram K. et al.

Part of International journal of oncology, p. 461-470, 2016

• DOI for Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma
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Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.

Spiegelberg, Diana; Mortensen, Anja C; Selvaraju, Ram K; Eriksson, Olof et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 974-982, 2016

• DOI for Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.
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The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells

Spiegelberg, Diana; Dascalu, Adrian; Mortensen, Anja; Abramenkovs, Andris et al.

Part of Oncotarget, p. 35652-35666, 2015

• DOI for The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells
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Molecular imaging of EGFR and EGFRvIII for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model

Spiegelberg, Diana; Mortensen, Anja C.; Selvaraju, Ram Kumar; Eriksson, Olof et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015

A real-time in vitro assay as a potential predictor of in vivo tumour imaging properties

Spiegelberg, Diana; Stenberg, J.; Haylock, Anna-Karin; Nestor, Marika

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015

Improving EGFR imaging by use of an anti-EGFRvIII monoclonal antibody: characterizations in an in vivo squamous cell carcinoma model

Spiegelberg, Diana; Mortensen, Anja C.; Selvaraju, Ram Kumar; Stenberg, J. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015

Enhancing the effect of radiotherapy in cultured tumour cells using p53 therapy

Mortensen, Anja C.; Spiegelberg, Diana; Scott, A. M.; Lane, D. P. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015

In vivo characterization of the novel CD44v6-targeting Fab fragment AbD15179 for molecular imaging of squamous cell carcinoma: a dual-isotope study

Haylock, Anna-Karin; Spiegelberg, Diana; Nilvebrant, Johan; Sandström, Karl et al.

Part of EJNMMI Research, 2014

• DOI for In vivo characterization of the novel CD44v6-targeting Fab fragment AbD15179 for molecular imaging of squamous cell carcinoma: a dual-isotope study
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Impact of Conjugation of Antibodies and Antibody Fragments on Their Interaction With Target Antigens on Living Cells

Stenberg, Jonas; Bondza, Sina; Spiegelberg, Diana; Björkelund, Hanna et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells.

Häggblad Sahlberg, Sara; Spiegelberg, Diana; Glimelius, Bengt; Stenerlöw, Bo et al.

Part of PLOS ONE, 2014

• DOI for Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells.
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Characterization of CD44 variant expression in head and neck squamous cell carcinomas

Spiegelberg, Diana; Kuku, Gamze; Selvaraju, Ram; Nestor, Marika

Part of Tumor Biology, p. 2053-2062, 2014

• DOI for Characterization of CD44 variant expression in head and neck squamous cell carcinomas
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Determination of receptor protein binding site specificity and relative binding strength using a time-resolved competition assay

Barta, Pavel; Volkova, Marie; Dascalu, Adrian; Spiegelberg, Diana et al.

Part of Journal of pharmacological and toxicological methods, p. 145-151, 2014

• DOI for Determination of receptor protein binding site specificity and relative binding strength using a time-resolved competition assay

Choice of labeling and cell line influences interactions between the Fab fragment AbD15179 and its target antigen CD44v6

Stenberg, Jonas; Spiegelberg, Diana; Karlsson, Hampus; Nestor, Marika

Part of Nuclear Medicine and Biology, p. 140-147, 2014

• DOI for Choice of labeling and cell line influences interactions between the Fab fragment AbD15179 and its target antigen CD44v6

In vivo characterization of a novel engineered CD44v6-targeting bivalent antibody fragment AbD19384 for molecular imaging of squamous cell carcinoma

Mortensen, Anja C.; Spegelberg, Diana; Haylock, Anna-Karin; Selvaraju, Ram Kumar et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

Evaluation of biomarkers for imaging and radio-immunotherapy in combination with HSP90 inhibition in squamous cell carcinomas

Spiegelberg, Diana; Mortensen, Anja C.; Haylock, Anna-Karin; Selvaraju, Ram Kumar et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014

In vivo characterization of CD44v6-targeting Fab fragments for molecular imaging of squamous cell carcinoma: a dual isotope study

Spiegelberg, Diana; Haylock, Anna-Karin; Nestor, Marika

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013

The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines

Häggblad Sahlberg, Sara; Spiegelberg, Diana; Lennartsson, Johan; Nygren, Peter et al.

Part of International Journal of Oncology, p. 176-184, 2012

• DOI for The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines
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A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio

Sandström, Karl; Haylock, Anna-Karin; Spiegelberg, Diana; Qvarnström, Fredrik et al.

Part of International Journal of Oncology, p. 1525-1532, 2012

• DOI for A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio

Characterization of CD44 Variant Expression in Cultured Head & Neck Squamous Cell Carcinomas for Possible Use in Radio-Immunotargeting

Spiegelberg, Diana; Nestor, Marika

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012

Improved Tumor-to-Organ Ratios of a Novel ⁶⁷Ga-Human Epidermal Growth Factor Radionuclide Conjugate with Preadministered Antiepidermal Growth Factor Receptor Affibody Molecules

Sandström, Karl; Haylock, Anna-Karin; Velikyan, Irina; Spiegelberg, Diana et al.

Part of Cancer Biotherapy and Radiopharmaceuticals, p. 593-601, 2011

• DOI for Improved Tumor-to-Organ Ratios of a Novel ⁶⁷Ga-Human Epidermal Growth Factor Radionuclide Conjugate with Preadministered Antiepidermal Growth Factor Receptor Affibody Molecules

Molecular imaging of CD44v6-expressing squamous cell carcinoma using a novel engineered bivalent antibody fragment

Haylock, Anna-Karin; Spiegelberg, Diana; Mortensen, Anja; Selvaraju, Ram Kumar et al.

Copper-cysteamine nanoparticles in cancer treatment: a systematic review

Ejtema, Mahsa; Chegeni, Nahid; Langen, Britta; Marallu, Mousa Ahmadi et al.

Part of Cell Biology and Toxicology, 2025

• DOI for Copper-cysteamine nanoparticles in cancer treatment: a systematic review
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CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches

Spiegelberg, Diana; Nilvebrant, Johan

Part of Contrast Media & Molecular Imaging, 2017

• DOI for CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches
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Towards Personalized Cancer Therapy: New Diagnostic Biomarkers and Radiosensitization Strategies

Spiegelberg, Diana

2015

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Evaluation of biomarkers for imaging and radio-immunotherapy in combination with HSP90 inhibition in squamous cell carcinomas

Spiegelberg, Diana; Mortensen, Anja; Selvaraju, Ram Kumar; Eriksson, Olof et al.

The α-emitter Ra-223 induces clustered DNA damage and significantly reduces cell survival

Abramenkovs, Andris; Spiegelberg, Diana; Nilsson, Sten; Stenerlöw, Bo

Therapeutic combination of HSP90 inhibition and radiation therapy reduces tumor growth in a syngeneic neuroblastoma mouse model.

Berglund, Hanna; Pereira, Beatriz; Nestor, Marika; Spiegelberg, Diana