Diana Spiegelberg
- Mobiltelefon:
- 073-690 27 88
- E-post:
- diana.spiegelberg@igp.uu.se
- Besöksadress:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postadress:
- Rudbecklaboratoriet
751 85 UPPSALA
Forskare Docent vid Institutionen för kirurgiska vetenskaper; Öron-, näs- och halssjukdomar
- Mobiltelefon:
- 073-690 27 88
- E-post:
- Diana.Spiegelberg@surgsci.uu.se
- Besöksadress:
- Akademiska sjukhuset, ingång 78/79
751 85 Uppsala - Postadress:
- Akademiska sjukhuset, ingång 78/79
751 85 Uppsala

Publikationer
Senaste publikationer
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Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks
Ingår i Heliyon, 2025
- DOI för Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks
- Ladda ner fulltext (pdf) av Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks
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Ingår i Frontiers in Oncology, 2025
- DOI för Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
- Ladda ner fulltext (pdf) av Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
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Copper-cysteamine nanoparticles in cancer treatment: a systematic review
Ingår i Cell Biology and Toxicology, 2025
- DOI för Copper-cysteamine nanoparticles in cancer treatment: a systematic review
- Ladda ner fulltext (pdf) av Copper-cysteamine nanoparticles in cancer treatment: a systematic review
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Ingår i STAR Protocols, 2025
- DOI för Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry
- Ladda ner fulltext (pdf) av Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry
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In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup
Ingår i Clinical and Translational Radiation Oncology, 2025
- DOI för In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup
- Ladda ner fulltext (pdf) av In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup
Alla publikationer
Artiklar i tidskrift
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Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks
Ingår i Heliyon, 2025
- DOI för Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks
- Ladda ner fulltext (pdf) av Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks
-
Ingår i Frontiers in Oncology, 2025
- DOI för Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
- Ladda ner fulltext (pdf) av Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
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Ingår i STAR Protocols, 2025
- DOI för Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry
- Ladda ner fulltext (pdf) av Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry
-
In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup
Ingår i Clinical and Translational Radiation Oncology, 2025
- DOI för In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup
- Ladda ner fulltext (pdf) av In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup
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Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
Ingår i Scientific Reports, 2025
- DOI för Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
- Ladda ner fulltext (pdf) av Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
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Ingår i iScience, 2024
- DOI för MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
- Ladda ner fulltext (pdf) av MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
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Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Ingår i Nature Communications, 2024
- DOI för Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
- Ladda ner fulltext (pdf) av Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
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Ingår i Heliyon, 2023
- DOI för Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas
- Ladda ner fulltext (pdf) av Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas
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Ingår i Scientific Reports, 2023
- DOI för Combination therapy of tyrosine kinase inhibitor sorafenib with the HSP90 inhibitor onalespib as a novel treatment regimen for thyroid cancer
- Ladda ner fulltext (pdf) av Combination therapy of tyrosine kinase inhibitor sorafenib with the HSP90 inhibitor onalespib as a novel treatment regimen for thyroid cancer
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Ra-223 induces clustered DNA damage and inhibits cell survival in several prostate cancer cell lines
Ingår i Translational Oncology, 2022
- DOI för Ra-223 induces clustered DNA damage and inhibits cell survival in several prostate cancer cell lines
- Ladda ner fulltext (pdf) av Ra-223 induces clustered DNA damage and inhibits cell survival in several prostate cancer cell lines
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Ingår i Scientific Reports, 2022
- DOI för Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy
- Ladda ner fulltext (pdf) av Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy
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The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
Ingår i Cancer Research Communications, s. 1075-1088, 2022
- DOI för The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
- Ladda ner fulltext (pdf) av The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
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Ingår i Cancers, 2022
- DOI för Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein
- Ladda ner fulltext (pdf) av Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein
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Ingår i European Biophysics Journal, s. 979-991, 2021
- DOI för K-D determination from time-resolved experiments on live cells with LigandTracer and reconciliation with end-point flow cytometry measurements
- Ladda ner fulltext (pdf) av K-D determination from time-resolved experiments on live cells with LigandTracer and reconciliation with end-point flow cytometry measurements
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Ingår i Frontiers in Oncology, 2020
- DOI för Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib
- Ladda ner fulltext (pdf) av Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib
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Ingår i Frontiers in Oncology, 2020
- DOI för The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model
- Ladda ner fulltext (pdf) av The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model
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Ingår i Scientific Reports, 2020
- DOI för The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach
- Ladda ner fulltext (pdf) av The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 980-990, 2020
- DOI för The radiosensitizer Onalespib increases complete remission in Lu-177-DOTATATE-treated mice bearing neuroendocrine tumor xenografts
- Ladda ner fulltext (pdf) av The radiosensitizer Onalespib increases complete remission in Lu-177-DOTATATE-treated mice bearing neuroendocrine tumor xenografts
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The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells
Ingår i Frontiers in Oncology, 2019
- DOI för The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells
- Ladda ner fulltext (pdf) av The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells
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The HSP90 inhibitor onalespib potentiates Lu-177-DOTATATE therapy in neuroendocrine tumor cells
Ingår i International Journal of Oncology, s. 1287-1295, 2019
- DOI för The HSP90 inhibitor onalespib potentiates Lu-177-DOTATATE therapy in neuroendocrine tumor cells
- Ladda ner fulltext (pdf) av The HSP90 inhibitor onalespib potentiates Lu-177-DOTATATE therapy in neuroendocrine tumor cells
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Ingår i International Journal of Oncology, s. 1875-1885, 2018
- DOI för Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy
- Ladda ner fulltext (pdf) av Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018
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Potentiating Lu-177-DOTATATE Therapy By HSP90 Inhibition - First In Vivo Study
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018
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The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors
Ingår i Cancer Research, s. 5084-5093, 2018
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Radioiodination Of Small Stapled Peptides For p53 Therapy
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017
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In Vivo Assessment of p53 Therapy as a Way of Enhancing Therapeutic Effects of Radiation
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017
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The HSP90-inhibitor Onalespib Potentiates Lu-177-Dotatate Treatment of Neuroendocrine Tumors
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017
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HSP90 inhibition in angiosarcoma
Ingår i British Journal of Dermatology, s. 343-344, 2017
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A real-time in vitro assay as a potential predictor of in vivo tumor imaging properties
Ingår i Nuclear Medicine and Biology, s. 12-18, 2016
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Ingår i International journal of oncology, s. 461-470, 2016
- DOI för Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma
- Ladda ner fulltext (pdf) av Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 974-982, 2016
- DOI för Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.
- Ladda ner fulltext (pdf) av Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.
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Ingår i Oncotarget, s. 35652-35666, 2015
- DOI för The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells
- Ladda ner fulltext (pdf) av The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015
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A real-time in vitro assay as a potential predictor of in vivo tumour imaging properties
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015
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Enhancing the effect of radiotherapy in cultured tumour cells using p53 therapy
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015
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Ingår i EJNMMI Research, 2014
- DOI för In vivo characterization of the novel CD44v6-targeting Fab fragment AbD15179 for molecular imaging of squamous cell carcinoma: a dual-isotope study
- Ladda ner fulltext (pdf) av In vivo characterization of the novel CD44v6-targeting Fab fragment AbD15179 for molecular imaging of squamous cell carcinoma: a dual-isotope study
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014
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Ingår i PLOS ONE, 2014
- DOI för Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells.
- Ladda ner fulltext (pdf) av Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells.
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Characterization of CD44 variant expression in head and neck squamous cell carcinomas
Ingår i Tumor Biology, s. 2053-2062, 2014
- DOI för Characterization of CD44 variant expression in head and neck squamous cell carcinomas
- Ladda ner fulltext (pdf) av Characterization of CD44 variant expression in head and neck squamous cell carcinomas
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Ingår i Journal of pharmacological and toxicological methods, s. 145-151, 2014
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Ingår i Nuclear Medicine and Biology, s. 140-147, 2014
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2013
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Ingår i International Journal of Oncology, s. 176-184, 2012
- DOI för The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines
- Ladda ner fulltext (pdf) av The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines
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A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio
Ingår i International Journal of Oncology, s. 1525-1532, 2012
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Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2012
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Ingår i Cancer Biotherapy and Radiopharmaceuticals, s. 593-601, 2011
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Artiklar, forskningsöversikt
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Copper-cysteamine nanoparticles in cancer treatment: a systematic review
Ingår i Cell Biology and Toxicology, 2025
- DOI för Copper-cysteamine nanoparticles in cancer treatment: a systematic review
- Ladda ner fulltext (pdf) av Copper-cysteamine nanoparticles in cancer treatment: a systematic review
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CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches
Ingår i Contrast Media & Molecular Imaging, 2017
- DOI för CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches
- Ladda ner fulltext (pdf) av CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches