Christian Benedict
Senior Lecturer/Associate Professor at Department of Pharmaceutical Biosciences; Research; Pharmacology
- Telephone:
- +46 18 471 43 30
- Mobile phone:
- +46 70 425 02 15
- E-mail:
- christian.benedict@farmbio.uu.se
- Visiting address:
- Biomedicinskt centrum BMC, Husargatan 3
- Postal address:
- Box 591
751 24 UPPSALA
- Academic merits:
- PhD, Associate Professor
- CV:
- Download CV
- ORCID:
- 0000-0002-8911-4068
More information is available to staff who log in.
Short presentation
Keywords
- aging
- alzheimer
- circadian
- circadian disruption
- cohort
- diabetes
- experiments
- lifestyle
- memory
- obesity
- sleep
- sleep deprivation
Biography
My research focuses on how poor sleep patterns can negatively impact various aspects of health. I have discovered several behavioral and molecular mechanisms that link sleep loss with weight gain and insulin resistance. Additionally, my research has contributed significantly to the understanding of how a lack of sleep can compromise brain health both in the short and long term. I have publications in several prestigious journals, including Lancet Endocrinology Diabetes (Impact factor (IF): 44.9), Lancet Health Longevity (IF released in 2023), Current Biology (10.9), Nature Communications (17.7), NPJ Digital Medicine (15.4), Science Advances (14.1), Neurology (11.4), Diabetes Care (17.2), Journal of Internal Medicine (13.1), and Alzheimer’s & Dementia (16.7). I have also co-organized scientific meetings, such as a Keystone symposium on the role of sleep and circadian rhythms in health, and have been invited to deliver keynote lectures, such as a talk on sleep and dementia at the 2021 Meeting of the Swiss Neurology Society. My research has garnered over 12,000 citations and an h-index of 58, which speaks to my recognition as an established researcher in the field of sleep science and chronobiology. Additionally, I have been entrusted with various roles, such as being elected as the scientific spokesman of the Swedish Sleep Society and appointed as a Ph.D. opponent, which further demonstrate my expertise in the field. I have mentored three Ph.D. students who have successfully defended their theses, as well as two postdoctoral researchers who have become independent and competitive principal investigators. These achievements attest to my leadership skills in guiding and mentoring the next generation of researchers.
Brief summary of my accomplishments:
• 51 original articles as last author; 28 original articles as first author
• Ph.D. in human biology (summa cum laude, 2008), docentship in neuroscience (2013), and lecturer in pharmacology (tenure track, since 2022)
• I have been awarded more than 20 mSEK as Principal Investigator from VR (2010-11, 2015-19), Novo Nordisk Fonden (2011, 2013, 2014-19, 2019-2021) and Hjärnfonden (2013-2017, 2019-2022)
• Past main supervisor of 3 Ph.D. students (Rångtell; Titova; van Egmond)
• Past main supervisor of 2 postdocs (Cedernaes; Tan)
• Google scholar: h-index 58, 12000 citations
• Since 2023 associate editor at SLEEP, the benchmark international journal for sleep and circadian science
• Scientific Spokesman of the Swedish Sleep Society (SFSS)
• Author of two popular-scientific books on sleep, demonstrating the ability to communicate complex scientific concepts to a broader audience and contributing to public engagement and outreach activities.
• Most promising young researcher at Uppsala University, all disciplines (Oscarspriset from Uppsala University, 2014)
Research
As an Associate Professor in Pharmacology at Uppsala University, I am leading a team of scientists dedicated to exploring the detrimental health effects of disrupted sleep. Our research findings have contributed to our understanding of the critical role of sleep in maintaining weight control, regulating glucose metabolism, and promoting brain health. Findings have been published in reputable scientific journals such as Nature Communications, Current Biology, Science Advances, Neurology, Diabetes Care, and Lancet Diabetes & Endocrinology, to name a few.
Join us as we continue to uncover the mysteries of sleep and its essential role in maintaining optimal health!
Publications
Selection of publications
- Reverse Dipping of Systolic Blood Pressure Is Associated With Increased Dementia Risk in Older Men (2021)
- Chronotype preference and glycemic control in type 2 diabetes (2021)
- Oral Antidiabetics and Sleep Among Type 2 Diabetes Patients (2021)
- Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men (2020)
- Sleep characteristics and HbA1c in patients with type 2 diabetes on glucose-lowering medication (2020)
- Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank (2020)
- Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans (2018)
- Association between long sleep duration and increased risk of obesity and type 2 diabetes (2018)
- Aiding sleep in type 2 diabetes (2018)
- Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease (2017)
- Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men (2015)
- Associations of self-reported sleep disturbance and duration with academic failure in community-dwelling Swedish adolescents (2015)
- Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men (2014)
- Association between physical activity and brain health in older adults (2013)
Recent publications
- Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID (2024)
- Nightmare frequency is a risk factor for suicidal ideation during the COVID-19 pandemic. (2024)
- Estimation bias and agreement limits between two common self-report methods of habitual sleep duration in epidemiological surveys. (2024)
- Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults (2024)
- Insomnia, OSA, and Mood Disorders (2024)
All publications
Articles
- Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID (2024)
- Nightmare frequency is a risk factor for suicidal ideation during the COVID-19 pandemic. (2024)
- Estimation bias and agreement limits between two common self-report methods of habitual sleep duration in epidemiological surveys. (2024)
- Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults (2024)
- Insomnia, OSA, and Mood Disorders (2024)
- Obstructive sleep apnea during rapid eye movement sleep and cognitive performance in adults (2024)
- Adequate sleep duration accentuates the effect of glucagon-like peptide-1 receptor variant on HbA1c (2024)
- Threshold-dependent association between non-rapid eye movement obstructive sleep apnea and interictal epileptiform discharges (2024)
- Association between age and comorbid insomnia and sleep apnea (2024)
- Adequate sleep is important for children's cardiometabolic health. (2024)
- Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individuals. (2024)
- Melatonin (2024)
- The dark side of light (2024)
- Melatonin (2024)
- OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study (2023)
- Acute Effects of Coffee Consumption. (2023)
- Shift workers are at increased risk of severe COVID-19 compared with day workers (2023)
- The association of insomnia with long COVID (2023)
- Association between accelerometer-measured amplitude of rest-activity rhythm and future health risk (2023)
- Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study (2023)
- Toward Precision Medicine (2023)
- Associations between changes in habitual sleep duration and lower self-rated health among COVID-19 survivors (2023)
- Sleep symptoms are essential features of long-COVID - Comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II) (2023)
- A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults (2023)
- A useful tool or a new challenge? Hand-wrist-worn sleep trackers in patients with insomnia. (2023)
- Association between hypersomnolence and the COVID-19 pandemic (2023)
- A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination (2023)
- Effects of acute sleep loss on leptin, ghrelin, and adiponectin in adults with healthy weight and obesity (2023)
- Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals. (2023)
- Sweet Dreams for Better Metabolic Health. (2023)
- Association of socioeconomic deprivation with sleep health in patients with type 2 diabetes. (2023)
- Association of poor sleep and HbA1c in metformin-treated patients with type 2 diabetes (2023)
- Association of accelerometer-derived circadian abnormalities and genetic risk with incidence of atrial fibrillation (2023)
- Association of Circadian Rest-Activity Rhythms with Cardiovascular Disease and Mortality in Type 2 Diabetes (2023)
- Objective sleep characteristics and continuous glucose monitoring profiles of type 2 diabetes patients in real-life settings (2023)
- Impaired procedural memory in narcolepsy type 1 (2022)
- Association of Daily Eating Duration and Day-To-Day Variability in the Timing of Eating With Fatal Cancer Risk in Older Men (2022)
- Acute sleep loss increases CNS health biomarkers and compromises the ability to stay awake in a sex-and weight-specific manner. (2022)
- Effects of One Night of Forced Wakefulness on Morning Resting Blood Pressure in Humans (2022)
- Self-reported regular daytime napping is associated with indicators of poor type 2 diabetes control (2022)
- Sleep Duration and Visceral Adipose Tissue (2022)
- Could a good night's sleep improve COVID-19 vaccine efficacy? (2021)
- Sleep in Female Healthcare Workers during COVID-19 (2021)
- Reverse Dipping of Systolic Blood Pressure Is Associated With Increased Dementia Risk in Older Men (2021)
- Chronotype preference and glycemic control in type 2 diabetes (2021)
- Oral Antidiabetics and Sleep Among Type 2 Diabetes Patients (2021)
- Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men (2020)
- Sleep characteristics and HbA1c in patients with type 2 diabetes on glucose-lowering medication (2020)
- Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank (2020)
- Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans (2018)
- Association between long sleep duration and increased risk of obesity and type 2 diabetes (2018)
- Aiding sleep in type 2 diabetes (2018)
- Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease (2017)
- Antihypertensive medication prior to nocturnal sleep reduces the risk of new-onset type 2 diabetes in hypertensive patients (2016)
- Association between shift work history and performance on the trail making test in middle-aged and elderly humans (2016)
- Self-reported sleep disturbance is associated with Alzheimer's disease risk in men (2015)
- Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men (2015)
- Associations of self-reported sleep disturbance and duration with academic failure in community-dwelling Swedish adolescents (2015)
- Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men (2014)
- Association between physical activity and brain health in older adults (2013)