Dan Larhammar
Professor at Department of Medical Cell Biology; Research group Dan Larhammar
- Telephone:
- +46 70 634 92 14
- E-mail:
- dan.larhammar@uu.se
- Visiting address:
- BMC
Husargatan 3
751 23 Uppsala - Postal address:
- Box 571
751 23 UPPSALA
- Academic merits:
- PhD, Associate Professor
- CV:
- Download CV
Short presentation
Dan Larhammar is professor of molecular cell biology since 1994. Pharmacist degree in 1980, PhD at the Faculty of Medicine in 1984. Member of the Royal Swedish Academy of Sciences since 2007, presently its president. His research concerns evolution, neurobiology, endocrinology and pharmacology. He also has a strong interest in the distinction between science and pseudoscience. He has supervised 22 students to PhD degree. His research group presently has three members.

Publications
Recent publications
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Reformation of science publishing: the Stockholm Declaration
Part of Royal Society Open Science, 2025
- DOI for Reformation of science publishing: the Stockholm Declaration
- Download full text (pdf) of Reformation of science publishing: the Stockholm Declaration
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Part of Molecular biology and evolution, 2025
- DOI for Divergence of Leptin Receptor and Interleukin-6 Receptor Subunit b in Early Vertebrate Evolution and Physiological Insights from the Sea Lamprey
- Download full text (pdf) of Divergence of Leptin Receptor and Interleukin-6 Receptor Subunit b in Early Vertebrate Evolution and Physiological Insights from the Sea Lamprey
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Part of Bi-lagan, p. 7-11, 2023
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
Part of British Journal of Pharmacology, 2023
- DOI for The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
- Download full text (pdf) of The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
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Part of International Journal of Biological Macromolecules, 2023
- DOI for Identification of a new Kir6 potassium channel and comparison of properties of Kir6 subtypes by structural modelling and molecular dynamics
- Download full text (pdf) of Identification of a new Kir6 potassium channel and comparison of properties of Kir6 subtypes by structural modelling and molecular dynamics
All publications
Articles in journal
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Reformation of science publishing: the Stockholm Declaration
Part of Royal Society Open Science, 2025
- DOI for Reformation of science publishing: the Stockholm Declaration
- Download full text (pdf) of Reformation of science publishing: the Stockholm Declaration
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Part of Molecular biology and evolution, 2025
- DOI for Divergence of Leptin Receptor and Interleukin-6 Receptor Subunit b in Early Vertebrate Evolution and Physiological Insights from the Sea Lamprey
- Download full text (pdf) of Divergence of Leptin Receptor and Interleukin-6 Receptor Subunit b in Early Vertebrate Evolution and Physiological Insights from the Sea Lamprey
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Part of Bi-lagan, p. 7-11, 2023
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
Part of British Journal of Pharmacology, 2023
- DOI for The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
- Download full text (pdf) of The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
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Part of International Journal of Biological Macromolecules, 2023
- DOI for Identification of a new Kir6 potassium channel and comparison of properties of Kir6 subtypes by structural modelling and molecular dynamics
- Download full text (pdf) of Identification of a new Kir6 potassium channel and comparison of properties of Kir6 subtypes by structural modelling and molecular dynamics
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Part of PLOS ONE, 2022
- DOI for Ancient multiplicity in cyclic nucleotide-gated (CNG) cation channel repertoire was reduced in the ancestor of Olfactores before reexpansion by whole genome duplications in vertebrates
- Download full text (pdf) of Ancient multiplicity in cyclic nucleotide-gated (CNG) cation channel repertoire was reduced in the ancestor of Olfactores before reexpansion by whole genome duplications in vertebrates
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Part of Frontiers in Endocrinology, 2022
- DOI for The Evolution of Oxytocin and Vasotocin Receptor Genes in Jawed Vertebrates: A Clear Case for Gene Duplications Through Ancestral Whole-Genome Duplications
- Download full text (pdf) of The Evolution of Oxytocin and Vasotocin Receptor Genes in Jawed Vertebrates: A Clear Case for Gene Duplications Through Ancestral Whole-Genome Duplications
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Part of Frontiers in Endocrinology, 2022
- DOI for Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses
- Download full text (pdf) of Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses
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Part of Nano Today, 2022
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Protein kinase C family evolution in jawed vertebrates
Part of Developmental Biology, p. 77-90, 2021
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Part of Frontiers in Neuroscience, 2020
- DOI for Corticotropin-Releasing Hormone (CRH) Gene Family Duplications in Lampreys Correlate With Two Early Vertebrate Genome Doublings
- Download full text (pdf) of Corticotropin-Releasing Hormone (CRH) Gene Family Duplications in Lampreys Correlate With Two Early Vertebrate Genome Doublings
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Oxytocin Receptors Regulate Social Preference in Zebrafish
Part of Scientific Reports, 2020
- DOI for Oxytocin Receptors Regulate Social Preference in Zebrafish
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Part of Journal of Pharmacology and Experimental Therapeutics, p. 73-82, 2020
- DOI for The Neuropeptide Y Y-2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y-2 Activation Reduces Histaminergic and IL-31-Induced Itch
- Download full text (pdf) of The Neuropeptide Y Y-2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y-2 Activation Reduces Histaminergic and IL-31-Induced Itch
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Part of Journal of Internal Medicine, p. 210-213, 2020
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Part of Vision Research, p. 43-51, 2020
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Evolution of vertebrate nicotinic acetylcholine receptors
Part of BMC Evolutionary Biology, 2019
- DOI for Evolution of vertebrate nicotinic acetylcholine receptors
- Download full text (pdf) of Evolution of vertebrate nicotinic acetylcholine receptors
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Part of Neuropeptides, 2019
- DOI for Functional characterization in vitro of twelve naturally occurring variants of the human pancreatic polypeptide receptor NPY4R
- Download full text (pdf) of Functional characterization in vitro of twelve naturally occurring variants of the human pancreatic polypeptide receptor NPY4R
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Part of BMC Biotechnology, 2019
- DOI for Copy number determination of the gene for the human pancreatic polypeptide receptor NPY4R using read depth analysis and droplet digital PCR.
- Download full text (pdf) of Copy number determination of the gene for the human pancreatic polypeptide receptor NPY4R using read depth analysis and droplet digital PCR.
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The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch
Part of Journal of Investigative Dermatology, p. 2405-2411, 2018
- DOI for The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch
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Part of Molecular Pharmacology, p. 323-334, 2018
- DOI for Elucidation of the Binding Mode of the Carboxyterminal Region of Peptide YY to the Human Y-2 Receptor
- Download full text (pdf) of Elucidation of the Binding Mode of the Carboxyterminal Region of Peptide YY to the Human Y-2 Receptor
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Evolution of the growth hormone, prolactin, prolactin 2 and somatolactin family
Part of General and Comparative Endocrinology, p. 94-112, 2018
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Part of PLOS ONE, 2018
- DOI for Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference
- Download full text (pdf) of Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference
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Evolution of the muscarinic acetylcholine receptors in vertebrates
Part of eNeuro, 2018
- DOI for Evolution of the muscarinic acetylcholine receptors in vertebrates
- Download full text (pdf) of Evolution of the muscarinic acetylcholine receptors in vertebrates
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Structural basis of ligand binding modes at the neuropeptide Y Y-1 receptor
Part of Nature, p. 520-524, 2018
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Part of General and Comparative Endocrinology, p. 143-160, 2018
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Assessing and regulating homeopathic products
Part of Journal of Internal Medicine, p. 563-565, 2017
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Part of BMC Evolutionary Biology, 2016
- DOI for Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity
- Download full text (pdf) of Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity
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Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages
Part of Journal of Molecular Endocrinology, p. 73-86, 2016
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Part of PLOS ONE, 2015
- DOI for Transducin Duplicates in the Zebrafish Retina and Pineal Complex: Differential Specialisation after the Teleost Tetraploidisation
- Download full text (pdf) of Transducin Duplicates in the Zebrafish Retina and Pineal Complex: Differential Specialisation after the Teleost Tetraploidisation
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Characterization of peptide QRFP (26RFa) and its receptor from amphioxus, Branchiostoma floridae
Part of General and Comparative Endocrinology, p. 107-113, 2015
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Part of General and Comparative Endocrinology, p. 106-115, 2015
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Part of Nature Genetics, p. 524-525, 2014
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Molecular evolution of GPCRS: somatostatin/urotensin II receptors
Part of Journal of Molecular Endocrinology, 2014
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Part of General and Comparative Endocrinology, p. 162-170, 2014
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Unexpected multiplicity of QRFP receptors in early vertebrate evolution
Part of Frontiers in Neuroscience, p. 337, 2014
- DOI for Unexpected multiplicity of QRFP receptors in early vertebrate evolution
- Download full text (pdf) of Unexpected multiplicity of QRFP receptors in early vertebrate evolution
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Part of General and Comparative Endocrinology, p. 1-2, 2014
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Neuropeptide Y, social function and long-term outcome in schizophrenia
Part of Schizophrenia Research, p. 223-227, 2014
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Part of BMC Evolutionary Biology, p. 238, 2013
- DOI for The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications
- Download full text (pdf) of The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications
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Part of Biochemistry, p. 7987-7998, 2013
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Part of Peptides, p. 64-70, 2013
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Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b
Part of Frontiers in Neuroscience, 2013
- DOI for Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b
- Download full text (pdf) of Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b
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Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae
Part of Frontiers in Neuroscience, 2013
- DOI for Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae
- Download full text (pdf) of Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae
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Detecting ligand interactions with G protein-coupled receptors in real-time on living cells
Part of Biochemical and Biophysical Research Communications - BBRC, p. 820-824, 2013
- DOI for Detecting ligand interactions with G protein-coupled receptors in real-time on living cells
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Part of BMC Evolutionary Biology, p. 231, 2012
- DOI for The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements.
- Download full text (pdf) of The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements.
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Part of PLOS ONE, 2012
- DOI for Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions
- Download full text (pdf) of Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions
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Part of General and Comparative Endocrinology, p. 135-143, 2012
- DOI for The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, inclucing two distinct V2 subtypes
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Expansion of transducin subunit gene families in early vertebrate tetraploidizations
Part of Genomics, p. 203-211, 2012
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Test for personality characteristics in dogs used in research
Part of Journal of Veterinary Behavior, p. 327-338, 2012
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Tacka dna-explosionen för att du finns
Part of Forskning & Framsteg, p. 34-37, 2012
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Part of General and Comparative Endocrinology, p. 322-331, 2012
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Part of Neuropeptides, p. 293-300, 2011
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Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes
Part of Molecular biology and evolution, p. 859-871, 2011
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Regulation of Synaptic Vesicle Budding and Dynamin Function by an EHD ATPase
Part of Journal of Neuroscience, p. 13972-13980, 2011
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Part of Comparative Biochemistry and Physiology - Part B, p. 166-173, 2011
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Evolution of the insulin-like growth factor binding protein (IGFBP) family
Part of Endocrinology, p. 2278-2289, 2011
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Part of Regulatory Peptides, p. 50-58, 2011
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Part of Peptides, p. 1055-1061, 2010
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Part of Regulatory Peptides, p. 120-129, 2010
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Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates
Part of PloS one, 2010
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Evolution of vertebrate neuropeptide receptors
Part of Regulatory Peptides, p. 20-20, 2010
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Part of Endocrine, p. 312-324, 2009
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Steroid biosynthesis within the frog brain: a model of neuroendocrine regulation
Part of Annals of the New York Academy of Sciences, p. 83-92, 2009
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Early duplications of opioid receptor and Peptide genes in vertebrate evolution
Part of Annals of the New York Academy of Sciences, p. 451-453, 2009
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Part of Annals of the New York Academy of Sciences, p. 491-493, 2009
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Major genomic events and their consequences for vertebrate evolution and endocrinology
Part of Annals of the New York Academy of Sciences, p. 201-208, 2009
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Perspective on Roseroot (Rhodiola rosea) Studies
Part of Planta Medica, p. 1187-1190, 2009
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Part of Genomics, p. 254-260, 2009
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Melanocortin peptides affect the motivation to feed in rainbow trout (Oncorhynchus mykiss)
Part of General and Comparative Endocrinology, p. 134-138, 2009
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Part of BMC Evolutionary Biology, p. 254, 2008
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Evolution of vertebrate opioid receptors
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 15487-15492, 2008
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Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization
Part of Gene, p. 61-71, 2008
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Part of General and Comparative Endocrinology, p. 705-716, 2008
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Peptide hormone and receptor evolution
Part of General and Comparative Endocrinology, p. 147, 2007
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Part of General and Comparative Endocrinology, p. 337-342, 2007
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Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss
Part of Peptides, p. 1320-1327, 2006
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Part of The FEBS Journal, p. 2048-2063, 2006
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Uneven Evolutionary Rates of Bradykinin B1 and B2 Receptors in Vertebrate Lineages
Part of Gene, p. 100-108, 2006
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Reply to M.A. Persinger and S. A. Koren’s letter to the editor. Neuroscience Letters.
Part of Neuroscience Letters, 2005
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Part of Br J Pharmacol, p. 11-16, 2005
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Part of Neuroscience Letters, 2005
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Localization of neuropeptide Y receptor Y5 mRNA in the guinea pig brain
Part of Regulatory Peptides, p. 61-67, 2004
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Part of Biochemical Journal, p. 475-486, 2004
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[Blood group diet: fantasy and quackery]
Part of Lakartidningen, 2004
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Part of Eur J Pharmacol, p. 69-76, 2001
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Part of Journal of Receptor and Signal Transduction Research, p. 225-241, 1998
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Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5
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Part of PLOS ONE
Articles, review/survey
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Evolution of neuropeptide signalling systems
Part of Journal of Experimental Biology, 2018
- DOI for Evolution of neuropeptide signalling systems
- Download full text (pdf) of Evolution of neuropeptide signalling systems
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The Arg-Phe-amide peptide 26RFa/glutamine RF-amide peptide and its receptor: IUPHAR Review 24
Part of British Journal of Pharmacology, p. 3573-3607, 2017
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Evolution of vertebrate rod and cone phototransduction genes
Part of Philosophical Transactions of the Royal Society of London. Biological Sciences, p. 2867-2880, 2009
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Part of BMC Evolutionary Biology, p. 184, 2008
Chapters in book
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Ancestral vertebrate complexity of the opioid system
Part of Nociceptin Opioid, Academic Press, 2015
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Mystikens neurobiologi och helandets mystik
Part of Mystik och andlighet - kritiska perspektiv, p. 199-215, Dialogos Förlag, 2013
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Evolution of the opioid system.
Part of Handbook of Biologically Active Peptides, p. 1562-1569, Academic Press, 2013
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Neuropeptide phylogeny and evolution
Part of Encyclopedia of Neuroscience, p. 873-879, Academic Press, 2009
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Part of The encyclopedia of endocrine diseases, p. 343-345, Elsevier, 2004