Dan Larhammar
Professor i molekylär cellbiologi vid Institutionen för medicinsk cellbiologi; Forskargrupp Dan Larhammar
- Telefon:
- 070-634 92 14
- E-post:
- dan.larhammar@uu.se
- Besöksadress:
- BMC
Husargatan 3
751 23 Uppsala - Postadress:
- Box 571
751 23 UPPSALA
- Akademiska meriter:
- PhD, Docent
- CV:
- Ladda ned CV
Kort presentation
Dan Larhammar, professor i molekylär cellbiologi sedan 1994, professor emeritus sedan maj 2026. Erhöll apotekarexamen 1980, disputerade vid medicinska fakulteten 1984. Ledamot av Kungliga Vetenskapsakademien sedan 2007, Akademiens preses sedan 2018. Forskar inom områdena evolution, neurobiologi, endokrinologi och farmakologi. Har stort intresse för distinktionen mellan vetenskap och pseudovetenskap. Har handlett 22 doktorander till disputation och har haft 19 postdoktorer/gästforskare.

Publikationer
Senaste publikationer
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Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors
Ingår i Nature Communications, 2026
- DOI för Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors
- Ladda ner fulltext (pdf) av Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors
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Ingår i Molecular biology and evolution, 2026
- DOI för Evolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains
- Ladda ner fulltext (pdf) av Evolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains
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The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors
Ingår i British Journal of Pharmacology, 2025
- DOI för The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors
- Ladda ner fulltext (pdf) av The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors
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Reformation of science publishing: the Stockholm Declaration
Ingår i Royal Society Open Science, 2025
- DOI för Reformation of science publishing: the Stockholm Declaration
- Ladda ner fulltext (pdf) av Reformation of science publishing: the Stockholm Declaration
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Ingår i Molecular biology and evolution, 2025
- DOI för Divergence of Leptin Receptor and Interleukin-6 Receptor Subunit b in Early Vertebrate Evolution and Physiological Insights from the Sea Lamprey
- Ladda ner fulltext (pdf) av Divergence of Leptin Receptor and Interleukin-6 Receptor Subunit b in Early Vertebrate Evolution and Physiological Insights from the Sea Lamprey
Alla publikationer
Artiklar i tidskrift
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Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors
Ingår i Nature Communications, 2026
- DOI för Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors
- Ladda ner fulltext (pdf) av Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors
-
Ingår i Molecular biology and evolution, 2026
- DOI för Evolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains
- Ladda ner fulltext (pdf) av Evolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains
-
The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors
Ingår i British Journal of Pharmacology, 2025
- DOI för The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors
- Ladda ner fulltext (pdf) av The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors
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Reformation of science publishing: the Stockholm Declaration
Ingår i Royal Society Open Science, 2025
- DOI för Reformation of science publishing: the Stockholm Declaration
- Ladda ner fulltext (pdf) av Reformation of science publishing: the Stockholm Declaration
-
Ingår i Molecular biology and evolution, 2025
- DOI för Divergence of Leptin Receptor and Interleukin-6 Receptor Subunit b in Early Vertebrate Evolution and Physiological Insights from the Sea Lamprey
- Ladda ner fulltext (pdf) av Divergence of Leptin Receptor and Interleukin-6 Receptor Subunit b in Early Vertebrate Evolution and Physiological Insights from the Sea Lamprey
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Ingår i Bi-lagan, s. 7-11, 2023
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
Ingår i British Journal of Pharmacology, 2023
- DOI för The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
- Ladda ner fulltext (pdf) av The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
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Ingår i International Journal of Biological Macromolecules, 2023
- DOI för Identification of a new Kir6 potassium channel and comparison of properties of Kir6 subtypes by structural modelling and molecular dynamics
- Ladda ner fulltext (pdf) av Identification of a new Kir6 potassium channel and comparison of properties of Kir6 subtypes by structural modelling and molecular dynamics
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Ingår i PLOS ONE, 2022
- DOI för Ancient multiplicity in cyclic nucleotide-gated (CNG) cation channel repertoire was reduced in the ancestor of Olfactores before reexpansion by whole genome duplications in vertebrates
- Ladda ner fulltext (pdf) av Ancient multiplicity in cyclic nucleotide-gated (CNG) cation channel repertoire was reduced in the ancestor of Olfactores before reexpansion by whole genome duplications in vertebrates
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Ingår i Frontiers in Endocrinology, 2022
- DOI för The Evolution of Oxytocin and Vasotocin Receptor Genes in Jawed Vertebrates: A Clear Case for Gene Duplications Through Ancestral Whole-Genome Duplications
- Ladda ner fulltext (pdf) av The Evolution of Oxytocin and Vasotocin Receptor Genes in Jawed Vertebrates: A Clear Case for Gene Duplications Through Ancestral Whole-Genome Duplications
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Ingår i Frontiers in Endocrinology, 2022
- DOI för Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses
- Ladda ner fulltext (pdf) av Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses
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Ingår i Nano Today, 2022
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Protein kinase C family evolution in jawed vertebrates
Ingår i Developmental Biology, s. 77-90, 2021
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Ingår i Frontiers in Neuroscience, 2020
- DOI för Corticotropin-Releasing Hormone (CRH) Gene Family Duplications in Lampreys Correlate With Two Early Vertebrate Genome Doublings
- Ladda ner fulltext (pdf) av Corticotropin-Releasing Hormone (CRH) Gene Family Duplications in Lampreys Correlate With Two Early Vertebrate Genome Doublings
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Oxytocin Receptors Regulate Social Preference in Zebrafish
Ingår i Scientific Reports, 2020
- DOI för Oxytocin Receptors Regulate Social Preference in Zebrafish
- Ladda ner fulltext (pdf) av Oxytocin Receptors Regulate Social Preference in Zebrafish
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Ingår i Journal of Pharmacology and Experimental Therapeutics, s. 73-82, 2020
- DOI för The Neuropeptide Y Y-2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y-2 Activation Reduces Histaminergic and IL-31-Induced Itch
- Ladda ner fulltext (pdf) av The Neuropeptide Y Y-2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y-2 Activation Reduces Histaminergic and IL-31-Induced Itch
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Ingår i Journal of Internal Medicine, s. 210-213, 2020
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Ingår i Vision Research, s. 43-51, 2020
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Evolution of vertebrate nicotinic acetylcholine receptors
Ingår i BMC Evolutionary Biology, 2019
- DOI för Evolution of vertebrate nicotinic acetylcholine receptors
- Ladda ner fulltext (pdf) av Evolution of vertebrate nicotinic acetylcholine receptors
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Ingår i Neuropeptides, 2019
- DOI för Functional characterization in vitro of twelve naturally occurring variants of the human pancreatic polypeptide receptor NPY4R
- Ladda ner fulltext (pdf) av Functional characterization in vitro of twelve naturally occurring variants of the human pancreatic polypeptide receptor NPY4R
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Ingår i BMC Biotechnology, 2019
- DOI för Copy number determination of the gene for the human pancreatic polypeptide receptor NPY4R using read depth analysis and droplet digital PCR.
- Ladda ner fulltext (pdf) av Copy number determination of the gene for the human pancreatic polypeptide receptor NPY4R using read depth analysis and droplet digital PCR.
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The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch
Ingår i Journal of Investigative Dermatology, s. 2405-2411, 2018
- DOI för The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch
- Ladda ner fulltext (pdf) av The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch
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Ingår i Molecular Pharmacology, s. 323-334, 2018
- DOI för Elucidation of the Binding Mode of the Carboxyterminal Region of Peptide YY to the Human Y-2 Receptor
- Ladda ner fulltext (pdf) av Elucidation of the Binding Mode of the Carboxyterminal Region of Peptide YY to the Human Y-2 Receptor
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Evolution of the growth hormone, prolactin, prolactin 2 and somatolactin family
Ingår i General and Comparative Endocrinology, s. 94-112, 2018
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Ingår i PLOS ONE, 2018
- DOI för Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference
- Ladda ner fulltext (pdf) av Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference
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Evolution of the muscarinic acetylcholine receptors in vertebrates
Ingår i eNeuro, 2018
- DOI för Evolution of the muscarinic acetylcholine receptors in vertebrates
- Ladda ner fulltext (pdf) av Evolution of the muscarinic acetylcholine receptors in vertebrates
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Structural basis of ligand binding modes at the neuropeptide Y Y-1 receptor
Ingår i Nature, s. 520-524, 2018
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Ingår i General and Comparative Endocrinology, s. 143-160, 2018
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Assessing and regulating homeopathic products
Ingår i Journal of Internal Medicine, s. 563-565, 2017
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Ingår i BMC Evolutionary Biology, 2016
- DOI för Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity
- Ladda ner fulltext (pdf) av Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity
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Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages
Ingår i Journal of Molecular Endocrinology, s. 73-86, 2016
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Ingår i PLOS ONE, 2015
- DOI för Transducin Duplicates in the Zebrafish Retina and Pineal Complex: Differential Specialisation after the Teleost Tetraploidisation
- Ladda ner fulltext (pdf) av Transducin Duplicates in the Zebrafish Retina and Pineal Complex: Differential Specialisation after the Teleost Tetraploidisation
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Characterization of peptide QRFP (26RFa) and its receptor from amphioxus, Branchiostoma floridae
Ingår i General and Comparative Endocrinology, s. 107-113, 2015
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Ingår i General and Comparative Endocrinology, s. 106-115, 2015
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Ingår i Nature Genetics, s. 524-525, 2014
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Molecular evolution of GPCRS: somatostatin/urotensin II receptors
Ingår i Journal of Molecular Endocrinology, 2014
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Ingår i General and Comparative Endocrinology, s. 1-2, 2014
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Unexpected multiplicity of QRFP receptors in early vertebrate evolution
Ingår i Frontiers in Neuroscience, s. 337, 2014
- DOI för Unexpected multiplicity of QRFP receptors in early vertebrate evolution
- Ladda ner fulltext (pdf) av Unexpected multiplicity of QRFP receptors in early vertebrate evolution
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Ingår i General and Comparative Endocrinology, s. 162-170, 2014
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Neuropeptide Y, social function and long-term outcome in schizophrenia
Ingår i Schizophrenia Research, s. 223-227, 2014
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Ingår i BMC Evolutionary Biology, s. 238, 2013
- DOI för The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications
- Ladda ner fulltext (pdf) av The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications
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Ingår i Peptides, s. 64-70, 2013
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Ingår i Biochemistry, s. 7987-7998, 2013
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Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae
Ingår i Frontiers in Neuroscience, 2013
- DOI för Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae
- Ladda ner fulltext (pdf) av Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae
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Detecting ligand interactions with G protein-coupled receptors in real-time on living cells
Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 820-824, 2013
- DOI för Detecting ligand interactions with G protein-coupled receptors in real-time on living cells
- Ladda ner fulltext (pdf) av Detecting ligand interactions with G protein-coupled receptors in real-time on living cells
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Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b
Ingår i Frontiers in Neuroscience, 2013
- DOI för Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b
- Ladda ner fulltext (pdf) av Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b
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Ingår i BMC Evolutionary Biology, s. 231, 2012
- DOI för The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements.
- Ladda ner fulltext (pdf) av The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements.
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Ingår i PLOS ONE, 2012
- DOI för Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions
- Ladda ner fulltext (pdf) av Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions
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Ingår i General and Comparative Endocrinology, s. 322-331, 2012
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Tacka dna-explosionen för att du finns
Ingår i Forskning & Framsteg, s. 34-37, 2012
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Test for personality characteristics in dogs used in research
Ingår i Journal of Veterinary Behavior, s. 327-338, 2012
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Ingår i General and Comparative Endocrinology, s. 135-143, 2012
- DOI för The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, inclucing two distinct V2 subtypes
- Ladda ner fulltext (pdf) av The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, inclucing two distinct V2 subtypes
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Expansion of transducin subunit gene families in early vertebrate tetraploidizations
Ingår i Genomics, s. 203-211, 2012
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Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes
Ingår i Molecular biology and evolution, s. 859-871, 2011
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Regulation of Synaptic Vesicle Budding and Dynamin Function by an EHD ATPase
Ingår i Journal of Neuroscience, s. 13972-13980, 2011
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Ingår i Neuropeptides, s. 293-300, 2011
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Evolution of the insulin-like growth factor binding protein (IGFBP) family
Ingår i Endocrinology, s. 2278-2289, 2011
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Ingår i Regulatory Peptides, s. 50-58, 2011
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Ingår i Comparative Biochemistry and Physiology - Part B, s. 166-173, 2011
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Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates
Ingår i PloS one, 2010
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Evolution of vertebrate neuropeptide receptors
Ingår i Regulatory Peptides, s. 20-20, 2010
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Ingår i Regulatory Peptides, s. 120-129, 2010
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Ingår i Peptides, s. 1055-1061, 2010
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Ingår i Endocrine, s. 312-324, 2009
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Steroid biosynthesis within the frog brain: a model of neuroendocrine regulation
Ingår i Annals of the New York Academy of Sciences, s. 83-92, 2009
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Early duplications of opioid receptor and Peptide genes in vertebrate evolution
Ingår i Annals of the New York Academy of Sciences, s. 451-453, 2009
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Ingår i Annals of the New York Academy of Sciences, s. 491-493, 2009
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Major genomic events and their consequences for vertebrate evolution and endocrinology
Ingår i Annals of the New York Academy of Sciences, s. 201-208, 2009
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Ingår i Genomics, s. 254-260, 2009
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Perspective on Roseroot (Rhodiola rosea) Studies
Ingår i Planta Medica, s. 1187-1190, 2009
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Melanocortin peptides affect the motivation to feed in rainbow trout (Oncorhynchus mykiss)
Ingår i General and Comparative Endocrinology, s. 134-138, 2009
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Ingår i BMC Evolutionary Biology, s. 254, 2008
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Evolution of vertebrate opioid receptors
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 15487-15492, 2008
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Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization
Ingår i Gene, s. 61-71, 2008
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Ingår i General and Comparative Endocrinology, s. 705-716, 2008
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Peptide hormone and receptor evolution
Ingår i General and Comparative Endocrinology, s. 147, 2007
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Ingår i General and Comparative Endocrinology, s. 337-342, 2007
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Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss
Ingår i Peptides, s. 1320-1327, 2006
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Ingår i The FEBS Journal, s. 2048-2063, 2006
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Uneven Evolutionary Rates of Bradykinin B1 and B2 Receptors in Vertebrate Lineages
Ingår i Gene, s. 100-108, 2006
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Reply to M.A. Persinger and S. A. Koren’s letter to the editor. Neuroscience Letters.
Ingår i Neuroscience Letters, 2005
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Ingår i Br J Pharmacol, s. 11-16, 2005
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Ingår i Neuroscience Letters, 2005
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Localization of neuropeptide Y receptor Y5 mRNA in the guinea pig brain
Ingår i Regulatory Peptides, s. 61-67, 2004
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Ingår i Biochemical Journal, s. 475-486, 2004
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[Blood group diet: fantasy and quackery]
Ingår i Lakartidningen, 2004
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Ingår i Eur J Pharmacol, s. 69-76, 2001
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Ingår i Journal of Receptor and Signal Transduction Research, s. 225-241, 1998
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Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5
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Ingår i PLOS ONE
Artiklar, forskningsöversikt
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Evolution of neuropeptide signalling systems
Ingår i Journal of Experimental Biology, 2018
- DOI för Evolution of neuropeptide signalling systems
- Ladda ner fulltext (pdf) av Evolution of neuropeptide signalling systems
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The Arg-Phe-amide peptide 26RFa/glutamine RF-amide peptide and its receptor: IUPHAR Review 24
Ingår i British Journal of Pharmacology, s. 3573-3607, 2017
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Evolution of vertebrate rod and cone phototransduction genes
Ingår i Philosophical Transactions of the Royal Society of London. Biological Sciences, s. 2867-2880, 2009
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Ingår i BMC Evolutionary Biology, s. 184, 2008
Kapitel i böcker, delar av antologi
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Ancestral vertebrate complexity of the opioid system
Ingår i Nociceptin Opioid, Academic Press, 2015
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Mystikens neurobiologi och helandets mystik
Ingår i Mystik och andlighet - kritiska perspektiv, s. 199-215, Dialogos Förlag, 2013
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Evolution of the opioid system.
Ingår i Handbook of Biologically Active Peptides, s. 1562-1569, Academic Press, 2013
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Neuropeptide phylogeny and evolution
Ingår i Encyclopedia of Neuroscience, s. 873-879, Academic Press, 2009
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Ingår i The encyclopedia of endocrine diseases, s. 343-345, Elsevier, 2004