Pernilla Lagerbäck

An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae

Zhao, Chenyan; van den Berg, Sanne; Wang, Zhigang; Olsson, Anna et al.

Part of International Journal of Antimicrobial Agents, 2025

• DOI for An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae
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Impact of porin deficiency on the synergistic potential of colistin in combination with β-lactam/β-lactamase inhibitors against ESBL- and carbapenemase-producing Klebsiella pneumoniae

Allander, Lisa; Vickberg, Karin; Fermér, Elin; Söderhäll, Thomas et al.

Part of Antimicrobial Agents and Chemotherapy, 2024

• DOI for Impact of porin deficiency on the synergistic potential of colistin in combination with β-lactam/β-lactamase inhibitors against ESBL- and carbapenemase-producing Klebsiella pneumoniae
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Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Zhao, Chenyan; Kristoffersson, Anders N.; Khan, David D.; Lagerbäck, Pernilla et al.

Part of Scientific Reports, 2024

• DOI for Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
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Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions

Olsson, Anna; Malmberg, Christer; Zhao, Chenyan; Friberg, Lena et al.

Part of Journal of Antimicrobial Chemotherapy, 2023

• DOI for Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions
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Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: agreement with in silico predictions.

Olsson, Anna; Malmberg, Christer; Zhao, Chenyan; Friberg, Lena et al.

Part of Journal of Antimicrobial Chemotherapy, 2023

• DOI for Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: agreement with in silico predictions.

An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae

Zhao, Chenyan; van den Berg, Sanne; Wang, Zhigang; Olsson, Anna et al.

Part of International Journal of Antimicrobial Agents, 2025

• DOI for An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae
• Download full text (pdf) of An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae

Impact of porin deficiency on the synergistic potential of colistin in combination with β-lactam/β-lactamase inhibitors against ESBL- and carbapenemase-producing Klebsiella pneumoniae

Allander, Lisa; Vickberg, Karin; Fermér, Elin; Söderhäll, Thomas et al.

Part of Antimicrobial Agents and Chemotherapy, 2024

• DOI for Impact of porin deficiency on the synergistic potential of colistin in combination with β-lactam/β-lactamase inhibitors against ESBL- and carbapenemase-producing Klebsiella pneumoniae
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Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Zhao, Chenyan; Kristoffersson, Anders N.; Khan, David D.; Lagerbäck, Pernilla et al.

Part of Scientific Reports, 2024

• DOI for Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
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Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions

Olsson, Anna; Malmberg, Christer; Zhao, Chenyan; Friberg, Lena et al.

Part of Journal of Antimicrobial Chemotherapy, 2023

• DOI for Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions
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Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: agreement with in silico predictions.

Olsson, Anna; Malmberg, Christer; Zhao, Chenyan; Friberg, Lena et al.

Part of Journal of Antimicrobial Chemotherapy, 2023

• DOI for Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: agreement with in silico predictions.

Activity of polymyxin B combinations against genetically well-characterised Klebsiella pneumoniae producing NDM-1 and OXA-48-like carbapenemases

Olsson, Anna; Allander, Lisa; Shams, Ayda; Al-Farsi, Hissa et al.

Part of International Journal of Antimicrobial Agents, 2023

• DOI for Activity of polymyxin B combinations against genetically well-characterised Klebsiella pneumoniae producing NDM-1 and OXA-48-like carbapenemases
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Human plasma protein levels alter the in vitro antifungal activity of caspofungin: An explanation to the effect in critically ill?

Kurland, Siri; Löwdin, Elisabeth; Furebring, Mia; Shams, Ayda et al.

Part of Mycoses, p. 79-87, 2022

• DOI for Human plasma protein levels alter the in vitro antifungal activity of caspofungin: An explanation to the effect in critically ill?
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Evaluation of In Vitro Activity of Double-Carbapenem Combinations against KPC-2-, OXA-48-and NDM-Producing Escherichia coli and Klebsiella pneumoniae

Allander, Lisa; Vickberg, Karin; Lagerbäck, Pernilla; Sandegren, Linus et al.

Part of Antibiotics, 2022

• DOI for Evaluation of In Vitro Activity of Double-Carbapenem Combinations against KPC-2-, OXA-48-and NDM-Producing Escherichia coli and Klebsiella pneumoniae
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Interactions of polymyxin B in combination with aztreonam, minocycline, meropenem and rifampicin against Escherichia coli producing NDM and OXA-48-group carbapenemases

Olsson, Anna; Hong, Marcus; Al-Farsi, Hissa; Giske, Christian G et al.

Part of Antimicrobial Agents and Chemotherapy, 2021

• DOI for Interactions of polymyxin B in combination with aztreonam, minocycline, meropenem and rifampicin against Escherichia coli producing NDM and OXA-48-group carbapenemases

Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data

Zhao, Chenyan; Wistrand-Yuen, Pikkei; Lagerbäck, Pernilla; Tängdén, Thomas et al.

Part of International Journal of Antimicrobial Agents, 2020

• DOI for Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data
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Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

Olsson, Anna; Wistrand-Yuen, Pikkei; Nielsen, Elisabet I.; Friberg, Lena et al.

Part of Antimicrobial Agents and Chemotherapy, 2020

• DOI for Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments
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Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments

Wistrand-Yuen, Pikkei; Olsson, Anna; Skarp, Kari Pekka; Friberg, Lena et al.

Part of Clinical Microbiology and Infection, p. 1214-1221, 2020

• DOI for Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments
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Synergistic and bactericidal activities of mecillinam, amoxicillin and clavulanic acid combinations against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in 24-h time-kill experiments

Skarp, Kari-Pekka; Shams, Ayda; Montelin, Hanna; Lagerbäck, Pernilla et al.

Part of International Journal of Antimicrobial Agents, p. 74-79, 2019

• DOI for Synergistic and bactericidal activities of mecillinam, amoxicillin and clavulanic acid combinations against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in 24-h time-kill experiments

Reply to Prim et al., "Is Colistin Susceptibility Testing Finally on the Right Track?"

Karvanen, Matti; Malmberg, Christer; Lagerbäck, Pernilla; Friberg, Lena E et al.

Part of Antimicrobial Agents and Chemotherapy, 2018

• DOI for Reply to Prim et al., "Is Colistin Susceptibility Testing Finally on the Right Track?"

Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Khan, David; Lagerbäck, Pernilla; Malmberg, Christer; Kristoffersson, Anders et al.

Part of International Journal of Antimicrobial Agents, p. 399-406, 2018

• DOI for Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Colistin is Extensively Lost during Standard in Vitro Experimental Conditions

Karvanen, Matti; Malmberg, Christer; Lagerbäck, Pernilla; Friberg, Lena E et al.

Part of Antimicrobial Agents and Chemotherapy, 2017

• DOI for Colistin is Extensively Lost during Standard in Vitro Experimental Conditions

Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics

Ungphakorn, Wanchana; Malmberg, Christer; Lagerbäck, Pernilla; Cars, Otto et al.

Part of Journal of Microbiological Methods, p. 69-75, 2017

• DOI for Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics

A Novel Microfluidic Assay for Rapid Phenotypic Antibiotic Susceptibility Testing of Bacteria Detected in Clinical Blood Cultures

Malmberg, Christer; Yuen, Pikkei; Spaak, Johanna; Cars, Otto et al.

Part of PLOS ONE, 2016

• DOI for A Novel Microfluidic Assay for Rapid Phenotypic Antibiotic Susceptibility Testing of Bacteria Detected in Clinical Blood Cultures
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Evaluation of antibacterial activities of colistin, rifampicin and meropenem combinations against NDM-1-producing Klebsiella pneumoniae in 24 h in vitro time-kill experiments

Lagerbäck, Pernilla; Khine, Wei W. T.; Giske, C. G.; Tängdén, Thomas

Part of Journal of Antimicrobial Chemotherapy, p. 2321-2325, 2016

• DOI for Evaluation of antibacterial activities of colistin, rifampicin and meropenem combinations against NDM-1-producing Klebsiella pneumoniae in 24 h in vitro time-kill experiments

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Khan, David D.; Lagerbäck, Pernilla; Cao, Sha; Lustig, Ulrika et al.

Part of Journal of Antimicrobial Chemotherapy, p. 3051-3060, 2015

• DOI for A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Evaluation of Double- and Triple-Antibiotic Combinations for VIM- and NDM-Producing Klebsiella pneumoniae by In Vitro Time-Kill Experiment

Tängdén, Thomas; Hickman, Rachel A.; Forsberg, Petter; Lagerbäck, Pernilla et al.

Part of Antimicrobial Agents and Chemotherapy, p. 1757-1762, 2014

• DOI for Evaluation of Double- and Triple-Antibiotic Combinations for VIM- and NDM-Producing Klebsiella pneumoniae by In Vitro Time-Kill Experiment

Structure of bacteriophage T4 endonuclease II mutant E118A, a tetrameric GIY-YIG enzyme

Andersson, Evalena; Lagerbäck, Pernilla; Carlson, Karin

Part of Journal of Molecular Biology, p. 1003-1016, 2010

• DOI for Structure of bacteriophage T4 endonuclease II mutant E118A, a tetrameric GIY-YIG enzyme

Bacteriophage T4 endonuclease II, a promiscuous GIY-YIG nuclease, binds as a tetramer to two DNA substrates

Lagerbäck, Pernilla; Andersson, Evalena; Malmberg, Christer; Carlson, Karin

Part of Nucleic Acids Research, p. 6174-6183, 2009

• DOI for Bacteriophage T4 endonuclease II, a promiscuous GIY-YIG nuclease, binds as a tetramer to two DNA substrates

Amino acid residues in the GIY-YIG endonuclease II of phage T4 affecting sequence recognition and binding as well as catalysis

Lagerbäck, Pernilla; Carlson, Karin

Part of Journal of Bacteriology, p. 5533-5544, 2008

• DOI for Amino acid residues in the GIY-YIG endonuclease II of phage T4 affecting sequence recognition and binding as well as catalysis

Bacteriophage T4 endonuclease II: concerted single-strand nicks yield double-strand cleavage.

Carlson, Karin; Lagerbäck, Pernilla; Anna-Chey, Nyström

Part of Mol Microbiol, p. 1403-1411, 2004

• DOI for Bacteriophage T4 endonuclease II: concerted single-strand nicks yield double-strand cleavage.

Endonuclease II - a GIY-YIG enzyme of bacteriophage T4

Lagerbäck, Pernilla

2008

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Translational PKPD modelling and simulation framework to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae

Zhao, Chenyan; van den Berg, Sanne; Wang, Zhigang; Olsson, Anna et al.

A framework to assess antibiotic effects using time-lapse microscopy

Wehrhahn, Eva; Zhao, Chenyan; Wistrand-Yuen, Pikkei; Brill, Margreke et al.