Helena Danielson
Professor at Department of Chemistry - BMC; Biochemistry; Danielson group
- Telephone:
- +46 18 471 45 45
- Mobile phone:
- +46 70 425 01 03
- E-mail:
- Helena.Danielson@kemi.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 576
75123 Uppsala
- ORCID:
- 0000-0003-2728-0340
Short presentation
Enzymology and drug discovery
Biography
Professor of Biochemistry at Uppsala University in Sweden since 2002. Platform Scientific Director at the SciLifeLab infrastructure unit for Biophysical Screening and Characterization and co-founder of Beactica Therapeutics AB.
Specialist in enzymology and drug discovery with a focus on biomolecular interaction analysis for detailed studies of enzyme-inhibitor interactions and other important recognition processes in the life science area. The work has involved studies of a variety of enzymes, primarily proteases and polymerases from viruses and other infectious organisms, or involved in important disease processes. Extensive experience of the commercial drug discovery process through over 30 years of collaborative research with partners in pharmaceutical and biotechnological industry.

Publications
Selection of publications
Part of Nucleic Acids Research, 2022
- DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
- Download full text (pdf) of Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
Part of Journal of the American Chemical Society, p. 2905-2920, 2022
- DOI for Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
- Download full text (pdf) of Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
Part of ChemBioChem, p. 1597-1608, 2021
- DOI for Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
- Download full text (pdf) of Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
Part of RSC Advances, p. 7527-7537, 2021
- DOI for Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
- Download full text (pdf) of Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
Unveiling the Biochemistry of the Epigenetic Regulator SMYD3
Part of Biochemistry, p. 3634-3645, 2019
Part of Journal of Medicinal Chemistry, p. 2292-2302, 2018
Biophysics in drug discovery: impact, challenges and opportunities
Part of Nature reviews. Drug discovery, p. 679-698, 2016
Recent publications
Part of Biosensors, 2025
- DOI for Regulatory effects of RNA-protein interactions revealed by reporter assays of bacteria grown on solid media
- Download full text (pdf) of Regulatory effects of RNA-protein interactions revealed by reporter assays of bacteria grown on solid media
Part of Bioorganic & Medicinal Chemistry, 2025
- DOI for Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point
- Download full text (pdf) of Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point
Part of Biochemistry, p. 2816-2829, 2024
- DOI for Unraveling the Bivalent and Rapid Interactions Between a Multivalent RNA Recognition Motif and RNA: A Kinetic Approach
- Download full text (pdf) of Unraveling the Bivalent and Rapid Interactions Between a Multivalent RNA Recognition Motif and RNA: A Kinetic Approach
Part of SLAS Discovery, p. 40-51, 2024
- DOI for Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors
- Download full text (pdf) of Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors
Part of RSC Medicinal Chemistry, p. 1982-1990, 2024
- DOI for Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening
- Download full text (pdf) of Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening
All publications
Articles in journal
Part of Biosensors, 2025
- DOI for Regulatory effects of RNA-protein interactions revealed by reporter assays of bacteria grown on solid media
- Download full text (pdf) of Regulatory effects of RNA-protein interactions revealed by reporter assays of bacteria grown on solid media
Part of Bioorganic & Medicinal Chemistry, 2025
- DOI for Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point
- Download full text (pdf) of Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point
Part of Biochemistry, p. 2816-2829, 2024
- DOI for Unraveling the Bivalent and Rapid Interactions Between a Multivalent RNA Recognition Motif and RNA: A Kinetic Approach
- Download full text (pdf) of Unraveling the Bivalent and Rapid Interactions Between a Multivalent RNA Recognition Motif and RNA: A Kinetic Approach
Part of SLAS Discovery, p. 40-51, 2024
- DOI for Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors
- Download full text (pdf) of Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors
Part of RSC Medicinal Chemistry, p. 1982-1990, 2024
- DOI for Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening
- Download full text (pdf) of Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening
The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity
Part of ChemMedChem, 2024
- DOI for The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity
- Download full text (pdf) of The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity
Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein
Part of Protein Expression and Purification, 2024
- DOI for Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein
- Download full text (pdf) of Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein
Part of Biomolecules, 2023
- DOI for The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces
- Download full text (pdf) of The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces
Part of Biomolecules, 2023
- DOI for The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase
- Download full text (pdf) of The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase
Amino acid substitutions in human growth hormone affect secondary structure and receptor binding
Part of PLOS ONE, 2023
- DOI for Amino acid substitutions in human growth hormone affect secondary structure and receptor binding
- Download full text (pdf) of Amino acid substitutions in human growth hormone affect secondary structure and receptor binding
Part of European Journal of Medicinal Chemistry, 2022
Part of Nucleic Acids Research, 2022
- DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
- Download full text (pdf) of Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
Part of Journal of the American Chemical Society, p. 2905-2920, 2022
- DOI for Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
- Download full text (pdf) of Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents
Part of Analytical Chemistry, p. 10054-10061, 2022
- DOI for Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents
- Download full text (pdf) of Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents
Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
Part of ChemBioChem, p. 1597-1608, 2021
- DOI for Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
- Download full text (pdf) of Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
Part of RSC Advances, p. 7527-7537, 2021
- DOI for Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
- Download full text (pdf) of Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
Part of FEBS Letters, p. 2406-2420, 2020
- DOI for A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells
- Download full text (pdf) of A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells
Part of Protein Science, p. 991-1003, 2020
- DOI for Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery
- Download full text (pdf) of Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery
Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
Part of ACS Omega, p. 3979-3995, 2020
- DOI for Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
- Download full text (pdf) of Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses
Part of ACS Sensors, p. 217-224, 2020
Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
Part of Cellular Signalling, 2020
- DOI for Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
- Download full text (pdf) of Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
Unveiling the Biochemistry of the Epigenetic Regulator SMYD3
Part of Biochemistry, p. 3634-3645, 2019
Part of Analytical Chemistry, p. 14697-14704, 2019
Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors
Part of Cell Reports, p. 1218-1230, 2018
- DOI for Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors
- Download full text (pdf) of Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors
Part of Journal of Medicinal Chemistry, p. 2292-2302, 2018
Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold
Part of European Journal of Medicinal Chemistry, p. 453-464, 2018
Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction
Part of European Biophysics Journal, 2017
Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction
Part of European Biophysics Journal, 2017
Part of Virology Journal, 2017
- DOI for Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition
- Download full text (pdf) of Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition
Insights from engineering the Affibody-Fc interaction with a computational-experimental method
Part of Protein Engineering Design & Selection, p. 593-601, 2017
Part of Viruses, 2017
- DOI for Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase
- Download full text (pdf) of Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase
Part of Journal of Pharmaceutical and Biomedical Analysis, p. 188-194, 2017
Part of Journal of Molecular Recognition, p. 1-11, 2017
- DOI for Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca2+/calmodulin-dependent kinase II
- Download full text (pdf) of Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca2+/calmodulin-dependent kinase II
Part of The FASEB Journal, p. 1204-1214, 2017
Part of Bioorganic & Medicinal Chemistry, p. 2603-2620, 2016
Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII
Part of Journal of Medicinal Chemistry, p. 2083-2093, 2016
Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria
Part of BMC Research Notes, p. 459, 2015
Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria
Part of BMC Research Notes, 2015
- DOI for Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria
- Download full text (pdf) of Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria
Identification and Characterization of an Irreversible Inhibitor of CDK2
Part of Chemistry and Biology, p. 1159-1164, 2015
- DOI for Identification and Characterization of an Irreversible Inhibitor of CDK2
- Download full text (pdf) of Identification and Characterization of an Irreversible Inhibitor of CDK2
Proximity-dependent initiation of hybridization chain reaction
Part of Nature Communications, 2015
- DOI for Proximity-dependent initiation of hybridization chain reaction
- Download full text (pdf) of Proximity-dependent initiation of hybridization chain reaction
Part of Proceedings of the National Academy of Sciences of the United States of America, 2015
Part of Journal of Medicinal Chemistry, p. 1802-1811, 2014
Part of Journal of enzyme inhibition and medicinal chemistry (Print), p. 868-876, 2014
Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014
Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region
Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014
Part of Journal of Medicinal Chemistry, p. 1802-1811, 2014
Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014
Part of Journal of Medicinal Chemistry, p. 1952-1963, 2014
Identification and characterization of an irreversible inhibitor of CDK2
Part of European Journal of Cancer, p. 106-106, 2014
Part of Antiviral Research, p. 356-368, 2013
Part of Marine Drugs, p. 4279-4293, 2013
- DOI for Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays
- Download full text (pdf) of Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays
Part of Biochemistry, p. 613-626, 2013
Part of MedChemComm, p. 432-442, 2013
Structural basis of ligand recognition in 5-HT3 receptors
Part of EMBO Reports, p. 49-56, 2013
On the Active Site Protonation State in Aspartic Proteases: Implications for Drug Design
Part of Current pharmaceutical design, p. 4257-4275, 2013
Part of Journal of Medicinal Chemistry, p. 2270-2282, 2013
Aliskiren displays long-lasting interactions with human renin
Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. 219-224, 2012
Part of Biochemical Pharmacology, p. 341-351, 2012
Part of Journal of Molecular Recognition, p. 495-503, 2012
Part of Bioorganic & Medicinal Chemistry, p. 4838-4847, 2012
AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin
Part of Journal of Neurochemistry, p. 714-726, 2012
Synthesis and SAR Around the R6 Position of 2(1H)-Pyrazinone Based HCV NS3 Protease Inhibitors
Part of Biopolymers, p. 457-457, 2011
Quantification of interactions between drug leads and serum proteins by use of "binding efficiency"
Part of Analytical Biochemistry, p. 163-175, 2011
Part of Journal of Medicinal Chemistry, 2011
Part of Angewandte Chemie International Edition, p. 1823-1827, 2011
A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane
Part of Analytical Biochemistry, p. 14-22, 2011
Part of Journal of Molecular Recognition, p. 60-70, 2011
Part of Journal of Medicinal Chemistry, p. 699-708, 2011
Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology
Part of Journal of Biomolecular Screening, p. 15-25, 2011
Part of Bioorganic & Medicinal Chemistry, p. 4917-4927, 2011
Hepatitis C Virus NS3 Protease Inhibitors based on 2(1H)-Pyrazinones
Part of Journal of Peptide Science, p. 95-95, 2010
Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones
Part of Bioorganic & Medicinal Chemistry, p. 6512-6525, 2010
Hepatitis C protease inhibitors based on 2(1H)-pyrazinones
Part of Abstracts of Papers of the American Chemical Society, 2010
Part of Antiviral Therapy, p. 841-852, 2010
Part of Bioorganic & Medicinal Chemistry, p. 5413-5424, 2010
Effect of the Protonation State of the Titratable Residues on the Inhibitor Affinity to BACE-1
Part of Biochemistry, p. 7255-7263, 2010
Biotinylated lipid bilayer disks as model membranes for biosensor analyses
Part of Analytical Biochemistry, p. 153-159, 2010
Part of Biochemical Pharmacology, p. 1133-1140, 2010
Part of Journal of Medicinal Chemistry, p. 7192-7201, 2010
Part of Analytical Biochemistry, p. 58-64, 2010
Part of Biochemistry, p. 8143-8154, 2010
Part of Future Medicinal Chemistry, p. 1399-1414, 2009
Screening for NNRTIs with Slow Dissociation and High Affinity for a Panel of HIV-1 RT Variants
Part of Journal of Biomolecular Screening, p. 395-403, 2009
Part of Journal of Neuroscience, p. 12584-12596, 2009
Part of Future Medicinal Chemistry, p. 1399-1414, 2009
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
Part of Journal of Virology, p. 11926-11939, 2009
Hepatitis C Virus NS3 Protease Is Activated by Low Concentrations of Protease Inhibitors
Part of Biochemistry, p. 11592-11602, 2009
Fragment library screening and lead characterization using SPR biosensors
Part of Current Topics in Medicinal Chemistry, p. 1725-1735, 2009
HSA binding of HIV protease inhibitors: a high-performance affinity chromatography study
Part of Journal of Separation Science, p. 1625-1631, 2009
Part of Analytical Biochemistry, p. 39-44, 2009
MIV-170, a novel NNRTI exhibiting tight binding to HIV-1 reverse transcriptase (RT)
Part of Antiviral Research, 2008
Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety
Part of Bioorganic & Medicinal Chemistry, p. 2955-2967, 2008
Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library
Part of Journal of Medicinal Chemistry, p. 3449-3459, 2008
Part of Bioorganic & Medicinal Chemistry, p. 5590-5605, 2008
Part of Bioorganic & Medicinal Chemistry, p. 1448-1474, 2007
Investigation of beta-amino acids as building blocks in hepatitis c virus NS3 protease inhibitors
Part of Biopolymers, p. 580-580, 2007
Phenylglycine as a Novel P2 Scaffold in Hepatitis C Virus NS3 Protease Inhibitors
Part of Bioorganic & Medicinal Chemistry, p. 1448-1474, 2007
Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3
Part of Journal of enzyme inhibition and medicinal chemistry (Print), p. 191-199, 2007
Part of Bioorganic & Medicinal Chemistry, p. 4057-4068, 2007
Part of The FEBS Journal, p. 5979-5986, 2007
Biomolecular Recognition of Glycosylated β3-Peptides by GalNAc Specific Lectins
Part of Journal of Molecular Recognition, p. 132-138, 2007
Part of Bioorganic & Medicinal Chemistry, p. 7344-7354, 2007
Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3
Part of Antiviral Therapy, p. 733-740, 2007
Detection of competitive enzyme inhibition with end point progress curve data
Part of Analytical Biochemistry, p. 11-19, 2006
Part of Journal of Biomolecular Screening, p. 165-175, 2006
Part of Journal of Medicinal Chemistry, p. 2375-87, 2006
Part of Biochemical Journal, p. 393-398, 2006
Part of Journal of Medicinal Chemistry, p. 2367-74, 2006
Part of Pharmazie, p. 717-721, 2006
Part of Bioorganic & Medicinal Chemistry, p. 544-559, 2006
Sensitivity analysis and error structure of progress curves
Part of Analytical Biochemistry, p. 1-10, 2006
Refolding of the full-length non-structural protein 3 of hepatitis C virus
Part of Protein Expression and Purification, p. 298-305, 2005
Part of Journal of Medicinal Chemistry, p. 3536-46, 2005
Part of Analytical Biochemistry, p. 203-214, 2004
Optimisation of peptide-based inhibitors of full-length hepatitis C virus NS3 protease
Part of Antiviral Research, 2004
Part of Journal of Medicinal Chemistry, p. 5953-61, 2004
Kinetic and thermodynamic characterization of HIV-1 protease inhibitors
Part of Journal of Molecular Recognition, p. 106-19, 2004
Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors
Part of Biochimica et Biophysica Acta, p. 51-59, 2004
Part of Biotechnology letters, p. 1729-1734, 2003
Part of Biochimica et Biophysica Acta - Proteins and Proteomics, p. 184-195, 2003
Part of Antiviral Research, p. 235-242, 2003
Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors
Part of European Journal of Biochemistry, p. 1746-1758, 2003
Part of Bioorganic & Medicinal Chemistry, p. 2955-2963, 2003
Part of Bioorganic & Medicinal Chemistry, p. 2551-2568, 2003
Part of Journal of Molecular Recognition, p. 203-212, 2003
Candida albicans secreted aspartic peptidase specificity: A chromogenic combinatorial approach
Part of Biopolymers, p. 310-P025, 2003
Part of Journal of Peptide Science, 2002
HIV-1 Vif-derived peptide inhibits drug-resistant HIV proteases
Part of Biochemical and Biophysical Research Communications - BBRC, p. 832-840, 2002
Part of Bioorganic & Medicinal Chemistry, p. 3915-22, 2002
Relationships between structure and interaction kinetics for HIV-1 protease inhibitors
Part of Journal of Medicinal Chemistry, p. 5430-5439, 2002
Resistance profiles of cyclic and linear inhibitors of HIV-1 protease
Part of Antiviral Chemistry & Chemotherapy, p. 27-37, 2002
Part of Protein Expression and Purification, p. 363-371, 2002
Part of Bioorganic & Medicinal Chemistry Letters, p. 203-206, 2001
Part of European journal of mass spectrometry, p. 385-391, 2001
Part of Journal of Medicinal Chemistry, p. 155-169, 2001
Part of European Journal of Pharmaceutical Sciences, p. 203-212, 2001
Part of Analytical Biochemistry, p. 207-218, 2001
Part of Journal of Biomolecular Screening, p. 353-359, 2000
Part of Analytical Biochemistry, p. 71-78, 2000
Part of Biochemistry, p. 9254-9263, 1999
Part of Journal of Medicinal Chemistry, p. 4054-4061, 1999
Part of Journal of Medicinal Chemistry, p. 3835-3844, 1999
Part of Antiviral Research, 1998
Investigation of an allosteric site of HIV-1 proteinase involved in inhibition by Cu2+
Part of Advances in Experimental Medicine and Biology, p. 99-103, 1998
Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology
Part of Analytical Biochemistry, p. 340-350, 1998
Cyclic 7-membered sulfamide HIV-1 protease inhibitors
Part of Antiviral Research, 1998
HIV-1 protease inhibitors based on acyclic carbohydrates
Part of Journal of Organic Chemistry, p. 4898-4906, 1998
Part of Journal of Medicinal Chemistry, p. 3782-3792, 1998
Part of Journal of natural products (Print), p. 2-7, 1998
Part of Tetrahedron, p. 7975-7984, 1997
Part of Journal of Medicinal Chemistry, p. 885-897, 1997
Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs
Part of Antimicrobial Agents and Chemotherapy, p. 2383-2388, 1997
Part of Tetrahedron Letters, p. 3483-3486, 1997
Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol
Part of Journal of carbohydrate chemistry, p. 555-569, 1996
The use of 5'-phosphate derivatives of nucleoside analogs as inhibitors of HIV-1 replication
Part of Antiviral Chemistry & Chemotherapy, p. 50-64, 1995
Part of Drug design and discovery, p. 43-54, 1995
Isothiocyanates as substrates for human glutathione transferases: structure-activity studies
Part of Biochemical Journal, p. 453-459, 1995
Part of Protein Engineering, p. 1115-1119, 1994
High-yield purification of HIV-1 proteinase expressed by a synthetic gene in Escherichia coli
Part of Protein Expression and Purification, p. 15-23, 1991
Part of Biochimica et Biophysica Acta, p. 307-312, 1990
Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases
Part of Journal of General Virology, p. 1985-1991, 1990
Part of FEBS Letters, p. 155-158, 1988
Part of Biochemical Journal, p. 705-711, 1988
Glutathione transferases - structure and catalytic activity
Part of Crc Critical Reviews in Biochemistry, p. 283-337, 1988
Expression of class-pi glutathione transferase in drug-resistant human-melanoma cells
Part of Proceedings of the American Association of Cancer Research, p. 5-5, 1987
Part of Biochemical Journal, p. 707-713, 1987
Part of Analytical Biochemistry, p. 313-320, 1985
4-Hydroxyalk-2-enals are substrates for glutathione transferase
Part of FEBS Letters, p. 267-270, 1985
Kinetic independence of the subunits of cytosolic glutathione transferase from the rat
Part of Biochemical Journal, p. 263-267, 1985
Part of Federation proceedings, p. 471-471, 1985
Inhibition of HIV-1 protease by Cu2+ occurs by a reversible allosteric mechanism involving His-69
Thermodynamic analysis of non-nucleoside inhibitor binding to HIV-1 reverse transcriptase
Articles, review/survey
Part of Proteomes, 2016
Biophysics in drug discovery: impact, challenges and opportunities
Part of Nature reviews. Drug discovery, p. 679-698, 2016
Conference papers
Part of Multifaceted Roles Of Crystallography In Modern Drug Discovery, p. 223-240, 2015
MIV-170: A novel NNRTI exhibiting tight binding to HIV-1 reverse transcriptase (RT)
2008
Investigation of beta-amino acids as building blocks in hepatitis c virus NS3 protease inhibitors
2007
Novel C-terminal functionalities in hepatitis C virus NS3 protease inhibitors
2005
Optimisation of peptide-based inhibitors of full-length hepatitis C virus NS3 protease
2004
Manuscripts (preprints)
Identification of complexities in HIV-1 protease - ligand interactions using biosensor technology
Initial evaluation of biotinylated bilayer disks as model membranes for biosensor analyses
Kinetic characterization of HCV NS3 inhibitors using an SPR biosensor
Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ
Design of a Stapled Peptide Targeting KLHL20Kelch: A Computational and Biosensor-based Approach