Helena Danielson

Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

Ingår i Nucleic Acids Research, 2022

• DOI för Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
• Ladda ner fulltext (pdf) av Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Ingår i Journal of the American Chemical Society, s. 2905-2920, 2022

• DOI för Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
• Ladda ner fulltext (pdf) av Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

FitzGerald, Edward A.; Butko, Margaret T.; Boronat, Pierre; Cederfelt, Daniela et al.

Ingår i RSC Advances, s. 7527-7537, 2021

• DOI för Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
• Ladda ner fulltext (pdf) av Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Talibov, Vladimir O; Fabini, Edoardo; FitzGerald, Edward; Tedesco, Daniele et al.

Ingår i ChemBioChem, s. 1597-1608, 2021

• DOI för Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
• Ladda ner fulltext (pdf) av Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Fabini, Edoardo; Talibov, Vladimir O; Mihalic, Filip; Naldi, Marina et al.

Ingår i Biochemistry, s. 3634-3645, 2019

• DOI för Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design

Linkuviene, Vaida; Talibov, Vladimir O; Danielson, U. Helena; Matulis, Daumantas

Ingår i Journal of Medicinal Chemistry, s. 2292-2302, 2018

• DOI för Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design

Biophysics in drug discovery: impact, challenges and opportunities

Renaud, Jean-Paul; Chung, Chun-wa; Danielson, U. Helena; Egner, Ursula et al.

Ingår i Nature reviews. Drug discovery, s. 679-698, 2016

• DOI för Biophysics in drug discovery: impact, challenges and opportunities

Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling

Myers, Nadine; Whittaker, Joanna; Cadot, Marie Elodie Helene; Varga, Julia K. et al.

Ingår i ChemBioChem, 2026

• DOI för Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling
• Ladda ner fulltext (pdf) av Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling

Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography

FitzGerald, Edward; Cederfelt, Daniela; Kovryzhenko, Daria; Boronat, Pierre et al.

Ingår i RSC Chemical Biology, s. 1625-1639, 2025

• DOI för Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography
• Ladda ner fulltext (pdf) av Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography

Deciphering the RNA recognition by Musashi-1 to design protein and RNA variants for in vitro and in vivo applications

Perez-Rafols, Anna; Perez-Ropero, Guillermo; Cerofolini, Linda; Sperotto, Luca et al.

Ingår i Nucleic Acids Research, 2025

• DOI för Deciphering the RNA recognition by Musashi-1 to design protein and RNA variants for in vitro and in vivo applications
• Ladda ner fulltext (pdf) av Deciphering the RNA recognition by Musashi-1 to design protein and RNA variants for in vitro and in vivo applications

Regulatory effects of RNA-protein interactions revealed by reporter assays of bacteria grown on solid media

Pérez-Ropero, Guillermo; Dolcemascolo, Roswitha; Pérez-Ràfols, Anna; Andersson, Karl et al.

Ingår i Biosensors, 2025

• DOI för Regulatory effects of RNA-protein interactions revealed by reporter assays of bacteria grown on solid media
• Ladda ner fulltext (pdf) av Regulatory effects of RNA-protein interactions revealed by reporter assays of bacteria grown on solid media

Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point

FitzGerald, Edward; Rachman, Moira; Cederfelt, Daniela; Myers, Nadine et al.

Ingår i Bioorganic & Medicinal Chemistry, 2025

• DOI för Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point
• Ladda ner fulltext (pdf) av Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point

Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling

Myers, Nadine; Whittaker, Joanna; Cadot, Marie Elodie Helene; Varga, Julia K. et al.

Ingår i ChemBioChem, 2026

• DOI för Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling
• Ladda ner fulltext (pdf) av Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling

Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography

FitzGerald, Edward; Cederfelt, Daniela; Kovryzhenko, Daria; Boronat, Pierre et al.

Ingår i RSC Chemical Biology, s. 1625-1639, 2025

• DOI för Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography
• Ladda ner fulltext (pdf) av Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography

Deciphering the RNA recognition by Musashi-1 to design protein and RNA variants for in vitro and in vivo applications

Perez-Rafols, Anna; Perez-Ropero, Guillermo; Cerofolini, Linda; Sperotto, Luca et al.

Ingår i Nucleic Acids Research, 2025

• DOI för Deciphering the RNA recognition by Musashi-1 to design protein and RNA variants for in vitro and in vivo applications
• Ladda ner fulltext (pdf) av Deciphering the RNA recognition by Musashi-1 to design protein and RNA variants for in vitro and in vivo applications

Regulatory effects of RNA-protein interactions revealed by reporter assays of bacteria grown on solid media

Pérez-Ropero, Guillermo; Dolcemascolo, Roswitha; Pérez-Ràfols, Anna; Andersson, Karl et al.

Ingår i Biosensors, 2025

• DOI för Regulatory effects of RNA-protein interactions revealed by reporter assays of bacteria grown on solid media
• Ladda ner fulltext (pdf) av Regulatory effects of RNA-protein interactions revealed by reporter assays of bacteria grown on solid media

Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point

FitzGerald, Edward; Rachman, Moira; Cederfelt, Daniela; Myers, Nadine et al.

Ingår i Bioorganic & Medicinal Chemistry, 2025

• DOI för Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point
• Ladda ner fulltext (pdf) av Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point

Unraveling the Bivalent and Rapid Interactions Between a Multivalent RNA Recognition Motif and RNA: A Kinetic Approach

Pérez-Ropero, Guillermo; Perez-Rafols, Anna; Martelli, Tommasso; Danielson, U. Helena et al.

Ingår i Biochemistry, s. 2816-2829, 2024

• DOI för Unraveling the Bivalent and Rapid Interactions Between a Multivalent RNA Recognition Motif and RNA: A Kinetic Approach
• Ladda ner fulltext (pdf) av Unraveling the Bivalent and Rapid Interactions Between a Multivalent RNA Recognition Motif and RNA: A Kinetic Approach

The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity

Blaazer, Antoni R.; Singh, Abhimanyu K.; Zara, Lorena; Boronat, Pierre et al.

Ingår i ChemMedChem, 2024

• DOI för The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity
• Ladda ner fulltext (pdf) av The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity

Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors

FitzGerald, Edward; Vagrys, Darius; Opassi, Giulia; Klein, Hanna F. et al.

Ingår i SLAS Discovery, s. 40-51, 2024

• DOI för Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors
• Ladda ner fulltext (pdf) av Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors

Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein

Fekry, Mostafa; Stenberg, Gun; Dobritzsch, Doreen; Danielson, U. Helena

Ingår i Protein Expression and Purification, 2024

• DOI för Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein
• Ladda ner fulltext (pdf) av Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein

Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening

FitzGerald, Edward A.; Cederfelt, Daniela; Lund, Bjarte Aarmo; Myers, Nadine et al.

Ingår i RSC Medicinal Chemistry, s. 1982-1990, 2024

• DOI för Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening
• Ladda ner fulltext (pdf) av Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening

The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces

Cederfelt, Daniela; Badgujar, Dilip; Au Musse, Ayan; Lohkamp, Bernhard et al.

Ingår i Biomolecules, 2023

• DOI för The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces
• Ladda ner fulltext (pdf) av The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces

The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase

Fekry, Mostafa; Dave, Khyati K.; Badgujar, Dilip; Hamnevik, Emil et al.

Ingår i Biomolecules, 2023

• DOI för The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase
• Ladda ner fulltext (pdf) av The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase

Amino acid substitutions in human growth hormone affect secondary structure and receptor binding

Rajkovic, Andrei; Kanchugal, Sandesh; Abdurakhmanov, Eldar; Howard, Rebecca et al.

Ingår i PLOS ONE, 2023

• DOI för Amino acid substitutions in human growth hormone affect secondary structure and receptor binding
• Ladda ner fulltext (pdf) av Amino acid substitutions in human growth hormone affect secondary structure and receptor binding

Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

Parenti, Marco Daniele; Naldi, Marina; Manoni, Elisabetta; Fabini, Edoardo et al.

Ingår i European Journal of Medicinal Chemistry, 2022

• DOI för Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

Ingår i Nucleic Acids Research, 2022

• DOI för Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
• Ladda ner fulltext (pdf) av Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Ingår i Journal of the American Chemical Society, s. 2905-2920, 2022

• DOI för Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
• Ladda ner fulltext (pdf) av Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents

Al-Amin, Rasel Abdullah; Muthelo, Phathutshedzo M.; Abdurakhmanov, Eldar; Vincke, Cecile et al.

Ingår i Analytical Chemistry, s. 10054-10061, 2022

• DOI för Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents
• Ladda ner fulltext (pdf) av Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

FitzGerald, Edward A.; Butko, Margaret T.; Boronat, Pierre; Cederfelt, Daniela et al.

Ingår i RSC Advances, s. 7527-7537, 2021

• DOI för Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
• Ladda ner fulltext (pdf) av Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Talibov, Vladimir O; Fabini, Edoardo; FitzGerald, Edward; Tedesco, Daniele et al.

Ingår i ChemBioChem, s. 1597-1608, 2021

• DOI för Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
• Ladda ner fulltext (pdf) av Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery

Opassi, Giulia; Nordström, Helena; Lundin, Arne; Napolitano, Valeria et al.

Ingår i Protein Science, s. 991-1003, 2020

• DOI för Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery
• Ladda ner fulltext (pdf) av Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery

A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells

Encarnacao, Joao Crispim; Napolitano, Valeria; Opassi, Giulia; Danielson, U. Helena et al.

Ingår i FEBS Letters, s. 2406-2420, 2020

• DOI för A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells
• Ladda ner fulltext (pdf) av A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells

Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Yang, Jie; Talibov, Vladimir O; Peintner, Stefan; Rhee, Claire et al.

Ingår i ACS Omega, s. 3979-3995, 2020

• DOI för Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
• Ladda ner fulltext (pdf) av Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses

Xu, Xingxing; Makaraviciute, Asta; Abdurakhmanov, Eldar; Werneling, Fredrik et al.

Ingår i ACS Sensors, s. 217-224, 2020

• DOI för Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses

Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Öhman Fuchs, Peder; Calitz, Carlemi; Pavlovic, Natasa; Binet, Francois et al.

Ingår i Cellular Signalling, 2020

• DOI för Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
• Ladda ner fulltext (pdf) av Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Fabini, Edoardo; Talibov, Vladimir O; Mihalic, Filip; Naldi, Marina et al.

Ingår i Biochemistry, s. 3634-3645, 2019

• DOI för Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Structural Changes of Mercaptohexanol Self-assembled Monolayers on Gold and their Influence on Impedimetric Aptamer Sensors

Xu, Xingxing; Makaraviciute, Asta; Kumar, Shalen; Wen, Chenyu et al.

Ingår i Analytical Chemistry, s. 14697-14704, 2019

• DOI för Structural Changes of Mercaptohexanol Self-assembled Monolayers on Gold and their Influence on Impedimetric Aptamer Sensors

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Pandya, Nikhil J; Seeger, Christian; Babai, Norbert; Gonzalez-Lozano, Miguel A et al.

Ingår i Cell Reports, s. 1218-1230, 2018

• DOI för Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors
• Ladda ner fulltext (pdf) av Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design

Linkuviene, Vaida; Talibov, Vladimir O; Danielson, U. Helena; Matulis, Daumantas

Ingår i Journal of Medicinal Chemistry, s. 2292-2302, 2018

• DOI för Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Ingår i European Journal of Medicinal Chemistry, s. 453-464, 2018

• DOI för Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Linkuviene, V.; Talibov, Vladimir O.; Danielson, U. Helena; Matulis, D.

Ingår i European Biophysics Journal, 2017

• DOI för Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Linkuviene, V.; Talibov, Vladimir O; Danielson, U. Helena; Matulis, D.

Ingår i European Biophysics Journal, 2017

• DOI för Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition

Solbak, Sara M.Ø.; Abdurakhmanov, Eldar; Vedeler, Anni; Danielson, U. Helena

Ingår i Virology Journal, 2017

• DOI för Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition
• Ladda ner fulltext (pdf) av Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition

Insights from engineering the Affibody-Fc interaction with a computational-experimental method

Nosrati, Masoumeh; Solbak, Sara; Nordesjö, Olle; Nissbeck, Mikael et al.

Ingår i Protein Engineering Design & Selection, s. 593-601, 2017

• DOI för Insights from engineering the Affibody-Fc interaction with a computational-experimental method

Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

Abdurakhmanov, Eldar; Solbak, Sara Oie; Danielson, U. Helena

Ingår i Viruses, 2017

• DOI för Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase
• Ladda ner fulltext (pdf) av Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

Monitoring drug-serum protein interactions for early ADME prediction through Surface Plasmon Resonance technology

Fabini, Edoardo; Danielson, U. Helena

Ingår i Journal of Pharmaceutical and Biomedical Analysis, s. 188-194, 2017

• DOI för Monitoring drug-serum protein interactions for early ADME prediction through Surface Plasmon Resonance technology

Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca²⁺/calmodulin-dependent kinase II

Seeger, Christian; Talibov, Vladimir O; Danielson, U. Helena

Ingår i Journal of Molecular Recognition, s. 1-11, 2017

• DOI för Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca²⁺/calmodulin-dependent kinase II
• Ladda ner fulltext (pdf) av Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca²⁺/calmodulin-dependent kinase II

Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Saupe, Falk; Reichel, Matthias; Huijbers, Elisabeth J. M.; Femel, Julia et al.

Ingår i The FASEB Journal, s. 1204-1214, 2017

• DOI för Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 2603-2620, 2016

• DOI för Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

Talibov, Vladimir O; Linkuvienė, Vaida; Matulis, Daumantas; Danielson, Helena U.

Ingår i Journal of Medicinal Chemistry, s. 2083-2093, 2016

• DOI för Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria

Huang, Hsin-Ho; Seeger, Christian; Danielson, U. Helena; Lindblad, Peter

Ingår i BMC Research Notes, 2015

• DOI för Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria
• Ladda ner fulltext (pdf) av Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria

Identification and Characterization of an Irreversible Inhibitor of CDK2

Anscombe, Elizabeth; Meschini, Elisa; Mora-Vidal, Regina; Martin, Mathew P. et al.

Ingår i Chemistry and Biology, s. 1159-1164, 2015

• DOI för Identification and Characterization of an Irreversible Inhibitor of CDK2
• Ladda ner fulltext (pdf) av Identification and Characterization of an Irreversible Inhibitor of CDK2

Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria

Danielson, U Helena; Huang, H H; Seeger, Christian; Lindblad, Peter

Ingår i BMC Research Notes, s. 459, 2015

Proximity-dependent initiation of hybridization chain reaction

Koos, Björn; Cane, Gaëlle; Grannas, Karin; Löf, Liza et al.

Ingår i Nature Communications, 2015

• DOI för Proximity-dependent initiation of hybridization chain reaction
• Ladda ner fulltext (pdf) av Proximity-dependent initiation of hybridization chain reaction

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

Spurny, Radovan; Debaveye, Sarah; Farinha, Ana; Veys, Ken et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2015

• DOI för Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

Identification of weak points of hepatitis C virus NS3 protease inhibitors using surface plasmon resonance biosensor-based interaction kinetic analysis and genetic variants

Svahn Gustafsson, Sofia; Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Mohammed Ikram et al.

Ingår i Journal of Medicinal Chemistry, s. 1802-1811, 2014

Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors

Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Muhammad Ikram; Svahn Gustafsson, Sofia et al.

Ingår i Journal of enzyme inhibition and medicinal chemistry (Print), s. 868-876, 2014

• DOI för Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 6595-6615, 2014

• DOI för Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Ingår i ACS Medicinal Chemistry Letters, s. 249-254, 2014

• DOI för Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Identification of Weak Points of Hepatitis C Virus NS3 Protease Inhibitors Using Surface Plasmon Resonance Biosensor-Based Interaction Kinetic Analysis and Genetic Variants

Svahn Gustafsson, Sofia; Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Muhammad Ikram et al.

Ingår i Journal of Medicinal Chemistry, s. 1802-1811, 2014

• DOI för Identification of Weak Points of Hepatitis C Virus NS3 Protease Inhibitors Using Surface Plasmon Resonance Biosensor-Based Interaction Kinetic Analysis and Genetic Variants

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Ingår i Journal of Medicinal Chemistry, s. 1790-1801, 2014

• DOI för Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

Manfroni, Giuseppe; Cannalire, Rolando; Barreca, Maria Letizia; Kaushik-Basu, Neerja et al.

Ingår i Journal of Medicinal Chemistry, s. 1952-1963, 2014

• DOI för The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

Identification and characterization of an irreversible inhibitor of CDK2

Martin, M.; Anscombe, E.; Meschini, E.; Staunton, D. et al.

Ingår i European Journal of Cancer, s. 106-106, 2014

• DOI för Identification and characterization of an irreversible inhibitor of CDK2

Resolution of the Interaction Mechanisms and Characteristics of Non-nucleoside Inhibitors of Hepatitis C Virus Polymerase - Laying the Foundation for Discovery of Allosteric HCV Drugs

Winquist, Johan; Abdurakhmanov, Eldar; Baraznenok, Vera; Henderson, Ian et al.

Ingår i Antiviral Research, s. 356-368, 2013

• DOI för Resolution of the Interaction Mechanisms and Characteristics of Non-nucleoside Inhibitors of Hepatitis C Virus Polymerase - Laying the Foundation for Discovery of Allosteric HCV Drugs

Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays

Christopeit, Tony; Øverbø, Kersti; Danielson, Helena; Nilsen, Inge W.

Ingår i Marine Drugs, s. 4279-4293, 2013

• DOI för Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays
• Ladda ner fulltext (pdf) av Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays

Identification of Structural-Kinetic and Structural-Thermodynamic Relationships for Thrombin Inhibitors

Winquist, Johan; Geschwindner, Stefan; Xue, Yafeng; Gustavsson, Lars et al.

Ingår i Biochemistry, s. 613-626, 2013

• DOI för Identification of Structural-Kinetic and Structural-Thermodynamic Relationships for Thrombin Inhibitors

Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

Barreca, Maria Letizia; Manfroni, Giuseppe; Leyssen, Pieter; Winquist, Johan et al.

Ingår i Journal of Medicinal Chemistry, s. 2270-2282, 2013

• DOI för Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

Structural basis of ligand recognition in 5-HT3 receptors

Kesters, D.; Thompson, A. J.; Brams, M.; Van Elk, R. et al.

Ingår i EMBO Reports, s. 49-56, 2013

• DOI för Structural basis of ligand recognition in 5-HT3 receptors

On the Active Site Protonation State in Aspartic Proteases: Implications for Drug Design

Sussman, Fredy; Carmen Villaverde, M.; Dominguez, Jose L.; Danielson, Helena

Ingår i Current pharmaceutical design, s. 4257-4275, 2013

• DOI för On the Active Site Protonation State in Aspartic Proteases: Implications for Drug Design

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Gossas, Thomas; Nordström, Helena; Xu, Ming-Hua; Sun, Zhi-Hua et al.

Ingår i MedChemComm, s. 432-442, 2013

• DOI för The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Aliskiren displays long-lasting interactions with human renin

Gossas, Thomas; Vrang, Lotta; Henderson, Ian; Sedig, Susanne et al.

Ingår i Naunyn-Schmiedeberg's Archives of Pharmacology, s. 219-224, 2012

• DOI för Aliskiren displays long-lasting interactions with human renin

Histaminergic pharmacology of homo-oligomeric beta 3 gamma-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology

Seeger, Christian; Christopeit, Tony; Fuchs, Karoline; Grote, Katharina et al.

Ingår i Biochemical Pharmacology, s. 341-351, 2012

• DOI för Histaminergic pharmacology of homo-oligomeric beta 3 gamma-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology

Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups

Dominguez, Jose L.; Gossas, Thomas; Carmen Villaverde, M.; Danielson, U. Helena et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 4838-4847, 2012

• DOI för Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups

AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin

Gorny, Xenia; Mikhaylova, Marina; Seeger, Christian; Reddy, Pasham Parameshwar et al.

Ingår i Journal of Neurochemistry, s. 714-726, 2012

• DOI för AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin

Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function

Seeger, Christian; Gorny, Xenia; Reddy, Pasham Parameshwar; Seidenbecher, Constanze et al.

Ingår i Journal of Molecular Recognition, s. 495-503, 2012

• DOI för Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function

Synthesis and SAR Around the R6 Position of 2(1H)-Pyrazinone Based HCV NS3 Protease Inhibitors

Belfrage, Anna-Karin; Gising, Johan; Örtqvist, Pernilla; Alogheli, Hiba et al.

Ingår i Biopolymers, s. 457-457, 2011

Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments

Brandt, Peter; Geitmann, Matthis; Danielson, U Helena

Ingår i Journal of Medicinal Chemistry, 2011

• DOI för Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments

Quantification of interactions between drug leads and serum proteins by use of "binding efficiency"

Gustafsson, Sofia S.; Vrang, Lotta; Terelius, Ylva; Danielson, Helena

Ingår i Analytical Biochemistry, s. 163-175, 2011

• DOI för Quantification of interactions between drug leads and serum proteins by use of "binding efficiency"

Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors

Geitmann, Matthis; Dahl, Göran; Danielson, U. Helena

Ingår i Journal of Molecular Recognition, s. 60-70, 2011

• DOI för Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors

A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane

Christopeit, Tony; Stenberg, Gun; Gossas, Thomas; Nyström, Susanne et al.

Ingår i Analytical Biochemistry, s. 14-22, 2011

• DOI för A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane

Powerful protein binders from designed polypeptides and small organic molecules: a general concept for protein recognition

Tegler, Lotta T.; Nonglaton, Guillaume; Büttner, Frank; Caldwell, Karin et al.

Ingår i Angewandte Chemie International Edition, s. 1823-1827, 2011

• DOI för Powerful protein binders from designed polypeptides and small organic molecules: a general concept for protein recognition

Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology

Elinder, Malin; Geitmann, Matthis; Gossas, Thomas; Källblad, Per et al.

Ingår i Journal of Biomolecular Screening, s. 15-25, 2011

• DOI för Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology

Identification of a Novel Scaffold for Allosteric Inhibition of Wild Type and Drug Resistant HIV-1 Reverse Transcriptase by Fragment Library Screening

Geitmann, Matthis; Elinder, Malin; Seeger, Christian; Brandt, Peter et al.

Ingår i Journal of Medicinal Chemistry, s. 699-708, 2011

• DOI för Identification of a Novel Scaffold for Allosteric Inhibition of Wild Type and Drug Resistant HIV-1 Reverse Transcriptase by Fragment Library Screening

P2-P1 ' macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Lampa, Anna; Ehrenberg, Angelica E.; Vema, Aparna; Åkerblom, Eva et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 4917-4927, 2011

• DOI för P2-P1 ' macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Hepatitis C Virus NS3 Protease Inhibitors based on 2(1H)-Pyrazinones

Belfrage, Anna-Karin; Gising, Johan; Örtqvist, Pernilla; Danielson, U Helena et al.

Ingår i Journal of Peptide Science, s. 95-95, 2010

Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Örtqvist, Pernilla; Gising, Johan; Ehrenberg, Angelica; Vema, Aparna et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 6512-6525, 2010

• DOI för Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Hepatitis C protease inhibitors based on 2(1H)-pyrazinones

Gising, Johan; Belfrage, Anna Karin; Örtqvist, Pernilla; Larhed, Mats et al.

Ingår i Abstracts of Papers of the American Chemical Society, 2010

Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Örtqvist, Pernilla; Vema, Aparna; Ehrenberg, Angelica E; Dahl, Göran et al.

Ingår i Antiviral Therapy, s. 841-852, 2010

• DOI för Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Lampa, Anna; Ehrenberg, Angelica E.; Gustafsson, Sofia S.; Vema, Aparna et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5413-5424, 2010

• DOI för Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Effect of the Protonation State of the Titratable Residues on the Inhibitor Affinity to BACE-1

Domínguez, José L; Christopeit, Tony; Villaverde, M Carmen; Gossas, Thomas et al.

Ingår i Biochemistry, s. 7255-7263, 2010

• DOI för Effect of the Protonation State of the Titratable Residues on the Inhibitor Affinity to BACE-1

Biotinylated lipid bilayer disks as model membranes for biosensor analyses

Lundquist, Anna; Hansen, Søren B; Nordström, Helena; Danielson, U Helena et al.

Ingår i Analytical Biochemistry, s. 153-159, 2010

• DOI för Biotinylated lipid bilayer disks as model membranes for biosensor analyses

Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism: Importance of slow dissociation and relaxation rates for antiviral efficacy

Elinder, Malin; Selhorst, Philippe; Vanham, Guido; Öberg, Bo et al.

Ingår i Biochemical Pharmacology, s. 1133-1140, 2010

• DOI för Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism: Importance of slow dissociation and relaxation rates for antiviral efficacy

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

de Kloe, Gerdien E; Retra, Kim; Geitmann, Matthis; Källblad, Per et al.

Ingår i Journal of Medicinal Chemistry, s. 7192-7201, 2010

• DOI för Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands

Retra, Kim; Geitmann, Matthis; Kool, Jeroen; Smit, August B et al.

Ingår i Analytical Biochemistry, s. 58-64, 2010

• DOI för Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

Geitmann, Matthis; Retra, Kim; de Kloe, Gerdien E; Homan, Evert et al.

Ingår i Biochemistry, s. 8143-8154, 2010

• DOI för Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process

Danielson, U Helena

Ingår i Future Medicinal Chemistry, s. 1399-1414, 2009

Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process

Danielson, U. Helena

Ingår i Future Medicinal Chemistry, s. 1399-1414, 2009

• DOI för Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process

Screening for NNRTIs with Slow Dissociation and High Affinity for a Panel of HIV-1 RT Variants

Elinder, Malin; Nordström, Helena; Geitmann, Matthis; Hämäläinen, Markku et al.

Ingår i Journal of Biomolecular Screening, s. 395-403, 2009

• DOI för Screening for NNRTIs with Slow Dissociation and High Affinity for a Panel of HIV-1 RT Variants

Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

Simister, Philip; Schmitt, Melanie; Geitmann, Matthis; Wicht, Oliver et al.

Ingår i Journal of Virology, s. 11926-11939, 2009

• DOI för Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

Hepatitis C Virus NS3 Protease Is Activated by Low Concentrations of  Protease Inhibitors

Dahl, Göran; Gutiérrez Arenas, Omar; Danielson, Helena

Ingår i Biochemistry, s. 11592-11602, 2009

• DOI för Hepatitis C Virus NS3 Protease Is Activated by Low Concentrations of  Protease Inhibitors

A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1

Wang, Xiaolu; Hu, Bin; Zieba, Agata; Neumann, Nicole G et al.

Ingår i Journal of Neuroscience, s. 12584-12596, 2009

• DOI för A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1

Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor

Christopeit, Tony; Gossas, Thomas; Danielson, Helena

Ingår i Analytical Biochemistry, s. 39-44, 2009

• DOI för Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor

HSA binding of HIV protease inhibitors: a high-performance affinity chromatography study

Bertucci, Carlo; Pistolozzi, Marco; Felix, Guy; Danielson, Helena

Ingår i Journal of Separation Science, s. 1625-1631, 2009

• DOI för HSA binding of HIV protease inhibitors: a high-performance affinity chromatography study

Fragment library screening and lead characterization using SPR biosensors

Danielson, U Helena

Ingår i Current Topics in Medicinal Chemistry, s. 1725-1735, 2009

• DOI för Fragment library screening and lead characterization using SPR biosensors

MIV-170, a novel NNRTI exhibiting tight binding to HIV-1 reverse transcriptase (RT)

Elinder, Malin; Danielson, U Helena; Unge, Torsten; van Ham, Guido et al.

Ingår i Antiviral Research, 2008

Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety

Rönn, Robert; Lampa, Anna; Peterson, Shane D.; Gossas, Thomas et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 2955-2967, 2008

• DOI för Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

Nordström, Helena; Gossas, Thomas; Hämäläinen, Markku; Källblad, Per et al.

Ingår i Journal of Medicinal Chemistry, s. 3449-3459, 2008

• DOI för Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

β-Amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors

Nurbo, Johanna; Peterson, Shane D.; Dahl, Göran; Danielson, U. Helena et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5590-5605, 2008

• DOI för β-Amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors

Evaluation of a diverse set of potential P-1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Rönn, Robert; Gossas, Thomas; Sabnis, Yogesh A; Daoud, H et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 1448-1474, 2007

Investigation of beta-amino acids as building blocks in hepatitis c virus NS3 protease inhibitors

Nurbo, Johanna; Dahl, Göran; Danielson, U Helena; Sandström, Anja

Ingår i Biopolymers, s. 580-580, 2007

Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3

Poliakov, Anton; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

Ingår i Journal of enzyme inhibition and medicinal chemistry (Print), s. 191-199, 2007

• DOI för Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3

Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Rönn, Robert; Gossas, Thomas; Sabnis, Yogesh A.; Daoud, Hanna et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 4057-4068, 2007

• DOI för Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3

Dahl, Göran; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

Ingår i The FEBS Journal, s. 5979-5986, 2007

• DOI för Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3

Phenylglycine as a Novel P2 Scaffold in Hepatitis C Virus NS3 Protease Inhibitors

Örtqvist, Pernilla; Peterson, Shane D.; Åkerblom, Eva; Gossas, Thomas et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 1448-1474, 2007

• DOI för Phenylglycine as a Novel P2 Scaffold in Hepatitis C Virus NS3 Protease Inhibitors

Biomolecular Recognition of Glycosylated β3-Peptides by GalNAc Specific Lectins

Norgren, Anna S.; Geitmann, Matthis; Danielson, U. Helena; Arvidsson, Per I.

Ingår i Journal of Molecular Recognition, s. 132-138, 2007

• DOI för Biomolecular Recognition of Glycosylated β3-Peptides by GalNAc Specific Lectins

Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis

Geitmann, Matthis; Danielson, U. Helena

Ingår i Bioorganic & Medicinal Chemistry, s. 7344-7354, 2007

• DOI för Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis

Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3

Dahl, Göran; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

Ingår i Antiviral Therapy, s. 733-740, 2007

Detection of competitive enzyme inhibition with end point progress curve data

Gutierrez Arenas, Omar; Danielson, U. Helena

Ingår i Analytical Biochemistry, s. 11-19, 2006

• DOI för Detection of competitive enzyme inhibition with end point progress curve data

Biosensor-based screening and characterization of HIV-1 inhibitor interactions with Sap1, Sap2 and Sap3 from Candida albicans

Backman, Dan; Monod, Michel; Danielson, U. Helena

Ingår i Journal of Biomolecular Screening, s. 165-175, 2006

• DOI för Biosensor-based screening and characterization of HIV-1 inhibitor interactions with Sap1, Sap2 and Sap3 from Candida albicans

Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance

Geitmann, Matthis; Unge, Torsten; Danielson, U. Helena

Ingår i Journal of Medicinal Chemistry, s. 2375-87, 2006

• DOI för Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance

Characterization of Ca2+ interactions with matrix metallopeptidase-12: implications for matrix metallopeptidase regulation

Gossas, Thomas; Danielson, Helena

Ingår i Biochemical Journal, s. 393-398, 2006

• DOI för Characterization of Ca2+ interactions with matrix metallopeptidase-12: implications for matrix metallopeptidase regulation

Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors

Geitmann, Matthis; Unge, Torsten; Danielson, U. Helena

Ingår i Journal of Medicinal Chemistry, s. 2367-74, 2006

• DOI för Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors

Inhibition of viral proteases by Zingiberaceae extracts and flavones isolated from Kaempferia parviflora

Sookkongwaree, K; Geitmann, Matthis; Roengsumran, S; Petsom, A et al.

Ingår i Pharmazie, s. 717-721, 2006

Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

Rönn, Robert; Sabnis, Yogesh A; Gossas, Thomas; Åkerblom, Eva et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 544-559, 2006

• DOI för Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

Sensitivity analysis and error structure of progress curves

Gutierrez Arenas, Omar; Danielson, U Helena

Ingår i Analytical Biochemistry, s. 1-10, 2006

• DOI för Sensitivity analysis and error structure of progress curves

Refolding of the full-length non-structural protein 3 of hepatitis C virus

Poliakov, Anton; Danielson, U. Helena

Ingår i Protein Expression and Purification, s. 298-305, 2005

• DOI för Refolding of the full-length non-structural protein 3 of hepatitis C virus

Early absorption and distribution analysis of antitumor and anti-AIDS drugs: lipid membrane and plasma protein interactions

Cimitan, Samanta; Lindgren, Maria T.; Bertucci, Carlo; Danielson, U. Helena

Ingår i Journal of Medicinal Chemistry, s. 3536-46, 2005

• DOI för Early absorption and distribution analysis of antitumor and anti-AIDS drugs: lipid membrane and plasma protein interactions

Optimisation of peptide-based inhibitors of full-length hepatitis C virus NS3 protease

Poliakov, Anton; Johansson, Anja; Åkerblom, Eva; Lindeberg, Gunnar et al.

Ingår i Antiviral Research, 2004

Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data

Shuman, Cynthia; Vrang, Lotta; Danielson, U. Helena

Ingår i Journal of Medicinal Chemistry, s. 5953-61, 2004

• DOI för Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data

Studies of substrate-induced conformational changes in human cytomegalovirus protease using optical biosensor technology

Geitmann, Matthis; Danielson, U. Helena

Ingår i Analytical Biochemistry, s. 203-214, 2004

• DOI för Studies of substrate-induced conformational changes in human cytomegalovirus protease using optical biosensor technology

Kinetic and thermodynamic characterization of HIV-1 protease inhibitors

Shuman, Cynthia F.; Hämäläinen, Markku; Danielson, U. Helena

Ingår i Journal of Molecular Recognition, s. 106-19, 2004

Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Poliakov, Anton; Johansson, Anja; Åkerblom, Eva; Oscarsson, Karin et al.

Ingår i Biochimica et Biophysica Acta, s. 51-59, 2004

• DOI för Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants

Shuman, Cynthia F.; Markgren, Per-Olof; Hämäläinen, Markku; Danielson, U. Helena

Ingår i Antiviral Research, s. 235-242, 2003

• DOI för Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants

Kinetic and mechanistic analysis of the association and dissociation of inhibitors interacting with secreted aspartic acid proteases 1 and 2 from Candida albicans

Backman, Dan; Danielson, U. Helena

Ingår i Biochimica et Biophysica Acta - Proteins and Proteomics, s. 184-195, 2003

• DOI för Kinetic and mechanistic analysis of the association and dissociation of inhibitors interacting with secreted aspartic acid proteases 1 and 2 from Candida albicans

Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors

Andersson, Hans O.; Fridborg, Kerstin; Löwgren, Seved; Alterman, Mathias et al.

Ingår i European Journal of Biochemistry, s. 1746-1758, 2003

• DOI för Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors

Refolding of a recombinant full-length non-structural (NS3) protein from hepatitis C virus by chromatographic procedures

Li, Ming; Poliakov, Anton; Danielson, U. Helena; Su, Zhiguo et al.

Ingår i Biotechnology letters, s. 1729-1734, 2003

• DOI för Refolding of a recombinant full-length non-structural (NS3) protein from hepatitis C virus by chromatographic procedures

Peptide-based inhibitors of hepatitis C virus full-length NS3 (protease-helicase/NTPase): model compounds towards small molecule inhibitors

Oscarsson, Karin; Poliakov, Anton; Oscarson, Stefan; Danielson, U. Helena et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 2955-2963, 2003

• DOI för Peptide-based inhibitors of hepatitis C virus full-length NS3 (protease-helicase/NTPase): model compounds towards small molecule inhibitors

Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-length NS3 (protease-helicase/NTPase): a comparative study of different C-terminals

Johansson, Anja; Poliakov, Anton; Åkerblom, Eva; Wiklund, Karin et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 2551-2568, 2003

• DOI för Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-length NS3 (protease-helicase/NTPase): a comparative study of different C-terminals

Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors

Gossas, Thomas; Danielson, U. Helena

Ingår i Journal of Molecular Recognition, s. 203-212, 2003

• DOI för Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors

Candida albicans secreted aspartic peptidase specificity: A chromogenic combinatorial approach

Beyer, B; Rubin, J; Johnson, J; Chung, A et al.

Ingår i Biopolymers, s. 310-P025, 2003

Tetrapeptides as potent protease inhibitors of Hepatitis C Virus full-length NS3 (protease-helicase/NTPase)

Johansson, Anja; Poliakov, Anton; Åkerblom, Eva; Lindeberg, Gunnar et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 3915-22, 2002

• DOI för Tetrapeptides as potent protease inhibitors of Hepatitis C Virus full-length NS3 (protease-helicase/NTPase)

Peptide-based protease inhibitors of the hepatitis C virus full-length NS3 protein (protease-helicase/NTPase)

Johansson, Anja; Åkerblom, Eva; Poliakov, Anton; Lindeberg, Gunnar et al.

Ingår i Journal of Peptide Science, 2002

HIV-1 Vif-derived peptide inhibits drug-resistant HIV proteases

Blumenzweig, I; Baraz, L; Friedler, A; Danielson, U. Helena et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 832-840, 2002

• DOI för HIV-1 Vif-derived peptide inhibits drug-resistant HIV proteases

Relationships between structure and interaction kinetics for HIV-1 protease inhibitors

Markgren, Per-Olof; Schaal, Wesley; Hämäläinen, Markku; Karlén, Anders et al.

Ingår i Journal of Medicinal Chemistry, s. 5430-5439, 2002

• DOI för Relationships between structure and interaction kinetics for HIV-1 protease inhibitors

Resistance profiles of cyclic and linear inhibitors of HIV-1 protease

Ahlsén, Göran; Hultén, Johan; Shuman, Cynthia; Poliakov, Anton et al.

Ingår i Antiviral Chemistry & Chemotherapy, s. 27-37, 2002

Expression and purification of recombinant full-length NS3 protease-helicase from a new variant of Hepatitis C virus

Poliakov, Anton; Hubatsch, Ina; Shuman, Cynthia F; Stenberg, Gun et al.

Ingår i Protein Expression and Purification, s. 363-371, 2002

• DOI för Expression and purification of recombinant full-length NS3 protease-helicase from a new variant of Hepatitis C virus

Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

Johansson, Anja; Hubatsch, Ina; Åkerblom, Eva; Lindeberg, Gunnar et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 203-206, 2001

• DOI för Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

Capture and analysis of low molecular weight ligands by surface plasmon resonance combined with mass spectrometry

Sönksen, C. P.; Roepstorff, P.; Markgren, Per-Olof; Danielson, U. Helena et al.

Ingår i European journal of mass spectrometry, s. 385-391, 2001

• DOI för Capture and analysis of low molecular weight ligands by surface plasmon resonance combined with mass spectrometry

Synthesis and comperative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors

Schaal, Wesley; Karlsson, Anna; Ahlsén, Göran; Lindberg, Jimmy et al.

Ingår i Journal of Medicinal Chemistry, s. 155-169, 2001

• DOI för Synthesis and comperative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors

P1/P1' modified HIV protease inhibitors as tools in two new sensitive surface plasmon resonance biosensor screening assays

Alterman, Mathias; Sjöbom, Hans; Säfsten, Pär; Markgren, Per-Olof et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 203-212, 2001

• DOI för P1/P1' modified HIV protease inhibitors as tools in two new sensitive surface plasmon resonance biosensor screening assays

Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology

Markgren, Per-Olof; Lindgren, Maria T.; Gertow, Karl; Karlsson, Robert et al.

Ingår i Analytical Biochemistry, s. 207-218, 2001

• DOI för Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology

Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen

Hämäläinen, Markku D.; Markgren, Per-Olof; Schaal, Wesley; Karlén, Anders et al.

Ingår i Journal of Biomolecular Screening, s. 353-359, 2000

• DOI för Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen

Kinetic analysis of the interaction between HIV-1 protease and inhibitors using optical biosensor technology

Markgren, Per-Olof; Hämäläinen, Markku; Danielson, U. Helena

Ingår i Analytical Biochemistry, s. 71-78, 2000

• DOI för Kinetic analysis of the interaction between HIV-1 protease and inhibitors using optical biosensor technology

Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site

Danielson, U. Helena; Jiang, Fanyi Y; Hansson, Lars O.; Mannervik, Bengt

Ingår i Biochemistry, s. 9254-9263, 1999

• DOI för Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site

Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains

Hultén, Johan; Andersson, Hans O.; Schaal, Wesley; Danielson, U. Helena et al.

Ingår i Journal of Medicinal Chemistry, s. 4054-4061, 1999

• DOI för Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains

Design and fast synthesis of C-terminal duplicated potent C₂-symmetric P1/P1'-modified HIV-1 protease inhibitors

Alterman, Mathias; Andersson, Hans O.; Garg, Neeraj; Ahlsén, Göran et al.

Ingår i Journal of Medicinal Chemistry, s. 3835-3844, 1999

• DOI för Design and fast synthesis of C-terminal duplicated potent C₂-symmetric P1/P1'-modified HIV-1 protease inhibitors

Cyclic 7-membered sulfamide HIV-1 protease inhibitors

Hultén, Johan; Schaal, Wesley; Unge, Torsten; Danielson, U Helena et al.

Ingår i Antiviral Research, 1998

Cyclic urea and sulfamide-based inhibitors of HIV-1 protease: Changes in binding mode upon modifications in the P1/P1 side chain

Bäckbro, Kristina; Andersson, Hans; Bonham, Nick M; Classon, Björn et al.

Ingår i Antiviral Research, 1998

Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology

Markgren, Per-Olof; Hämäläinen, Markku; Danielson, U. Helena

Ingår i Analytical Biochemistry, s. 340-350, 1998

• DOI för Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology

Investigation of an allosteric site of HIV-1 proteinase involved in inhibition by Cu2+

Danielson, Helena; Lindgren, Maria T.; Markgren, Per-Olof; Nillroth, Ulrika

Ingår i Advances in Experimental Medicine and Biology, s. 99-103, 1998

Development of a radiochemical cyclooxygenase-1 and 2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis

Noreen, Ylva; Ringbom, Therese; Perera, Premila; Danielson, Helena et al.

Ingår i Journal of natural products (Print), s. 2-7, 1998

• DOI för Development of a radiochemical cyclooxygenase-1 and 2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis

Design and synthesis of new potent C2-symmetric HIV-1 protease inhibitors: Use of L-mannaric acid as a peptidomimetic scaffold

Alterman, Mathias; Björsne, Magnus; Mühlman, Anna; Classon, Björn et al.

Ingår i Journal of Medicinal Chemistry, s. 3782-3792, 1998

• DOI för Design and synthesis of new potent C2-symmetric HIV-1 protease inhibitors: Use of L-mannaric acid as a peptidomimetic scaffold

HIV-1 protease inhibitors based on acyclic carbohydrates

Zuccarello, Guido; Bouzide, Abderrahim; Kvarnstrom, Ingemar; Niklasson, Gunilla et al.

Ingår i Journal of Organic Chemistry, s. 4898-4906, 1998

• DOI för HIV-1 protease inhibitors based on acyclic carbohydrates

Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors

Nöteberg, Daniel; Brånalt, Jonas; Kvarnström, Ingemar; Classon, Björn et al.

Ingår i Tetrahedron, s. 7975-7984, 1997

• DOI för Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors

Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities

Hultén, Johan; Bonham, Nicholas M; Nillroth, Ulrika; Hansson, Tomas et al.

Ingår i Journal of Medicinal Chemistry, s. 885-897, 1997

• DOI för Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities

Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs

Nillroth, Ulrika; Vrang, Lotta; Markgren, Per-Olof; Hultén, Johan et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 2383-2388, 1997

A convenient synthesis of 1-(S)-[1'-(S)-(t-butyloxycarbonylamino)-2'-phenylethyl]oxirane: a useful building block in the synthesis of HIV protease inhibitors

Brånalt, J; Kvarnstrom, I; Classon, B; Samuelsson, B et al.

Ingår i Tetrahedron Letters, s. 3483-3486, 1997

• DOI för A convenient synthesis of 1-(S)-[1'-(S)-(t-butyloxycarbonylamino)-2'-phenylethyl]oxirane: a useful building block in the synthesis of HIV protease inhibitors

Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol

Niklasson, Gunilla; Kvarnström, Ingemar; Classon, Björn; Samuelsson, Bertil et al.

Ingår i Journal of carbohydrate chemistry, s. 555-569, 1996

• DOI för Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol

The use of 5'-phosphate derivatives of nucleoside analogs as inhibitors of HIV-1 replication

Nillroth, Ulrika; Vrang, Lotta; Ahlsén, Göran; Besidsky, Y et al.

Ingår i Antiviral Chemistry & Chemotherapy, s. 50-64, 1995

Specific interaction between HIV-1 proteinase and 5'-phosphate peptidomimetic derivatives of nucleoside analogues

Nillroth, Ulrika; Besidsky, Yosef; Classon, Björn; Chattopahyaya, Jyoti et al.

Ingår i Drug design and discovery, s. 43-54, 1995

Isothiocyanates as substrates for human glutathione transferases: structure-activity studies

Kolm, Rüdiger H.; Danielson, U Helena; Zhang, Y.uesheng; Talalay, Paul et al.

Ingår i Biochemical Journal, s. 453-459, 1995

Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes

Chaga, Grigoriy; Widersten, Mikael; Andersson, Lennart; Porath, Jerker et al.

Ingår i Protein Engineering, s. 1115-1119, 1994

• DOI för Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes

High-yield purification of HIV-1 proteinase expressed by a synthetic gene in Escherichia coli

Goobar, Laura; Danielson, U Helena; Brodin, Peter; Grundström, Thomas et al.

Ingår i Protein Expression and Purification, s. 15-23, 1991

Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action

Neuzil, Jiri; Danielson, Helena; Welch, G Rickey; Ovádi, Judit

Ingår i Biochimica et Biophysica Acta, s. 307-312, 1990

• DOI för Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action

Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases

Wallin, Margareta; Deinum, Johanna; Goobar, Laura; Danielson, U Helena

Ingår i Journal of General Virology, s. 1985-1991, 1990

• DOI för Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases

Relaxed thiol substrate specificity of glutathione transferase effected by a non-substrate glutathione derivative

Principato, Giovanni B; Danielson, U Helena; Mannervik, Bengt

Ingår i FEBS Letters, s. 155-158, 1988

• DOI för Relaxed thiol substrate specificity of glutathione transferase effected by a non-substrate glutathione derivative

Paradoxical inhibition of rat glutathione transferase 4-4 by indomethacin explained by substrate-inhibitor-enzyme complexes in a random-order sequential mechanism

Danielson, U Helena; Mannervik, Bengt

Ingår i Biochemical Journal, s. 705-711, 1988

Glutathione transferases - structure and catalytic activity

Mannervik, Bengt; Danielson, U Helena

Ingår i Crc Critical Reviews in Biochemistry, s. 283-337, 1988

Expression of class-pi glutathione transferase in drug-resistant human-melanoma cells

Mannervik, Bengt; Castro, Victor M; Danielson, U Helena; Platz, A et al.

Ingår i Proceedings of the American Association of Cancer Research, s. 5-5, 1987

Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases

Danielson, U Helena; Esterbauer, Hermann; Mannervik, Bengt

Ingår i Biochemical Journal, s. 707-713, 1987

Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

Ålin, Per; Jensson, Helgi; Guthenberg, Claes; Danielson, U Helena et al.

Ingår i Analytical Biochemistry, s. 313-320, 1985

• DOI för Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

4-Hydroxyalk-2-enals are substrates for glutathione transferase

Ålin, Per; Danielson, U. Helena; Mannervik, Bengt

Ingår i FEBS Letters, s. 267-270, 1985

• DOI för 4-Hydroxyalk-2-enals are substrates for glutathione transferase

Kinetic independence of the subunits of cytosolic glutathione transferase from the rat

Danielson, U Helena; Mannervik, Bengt

Ingår i Biochemical Journal, s. 263-267, 1985

STRUCTURAL DATA AND ENZYMATIC-PROPERTIES DEFINING 3 CLASSES OF MAMMALIAN CYTOSOLIC GLUTATHIONE TRANSFERASE

Mannervik, Bengt; Ålin, P; Danielson, U Helena; Guthenberg, C et al.

Ingår i Federation proceedings, s. 471-471, 1985

Inhibition of HIV-1 protease by Cu2+ occurs by a reversible allosteric mechanism involving His-69

Lindgren, Maria T.; Markgren, Per-Olof; Nillroth, Ulrika; Danielson, U. Helena

Thermodynamic analysis of non-nucleoside inhibitor binding to HIV-1 reverse transcriptase

Geitmann, Matthis; Danielson, U. Helena

The high affinity of hydroxamate-based MMP-12 inhibitors is due to an inherently slow dissociation rate of the enzyme-inhibitor complex

Gossas, Thomas; Nordström, Helena; Wallberg, Hans; Danielson, Helena

Let There Be Light!

Raykova, Doroteya; Koos, Bjoern; Asplund, Anna; Gelleri, Marton et al.

Ingår i Proteomes, 2016

• DOI för Let There Be Light!
• Ladda ner fulltext (pdf) av Let There Be Light!

Biophysics in drug discovery: impact, challenges and opportunities

Renaud, Jean-Paul; Chung, Chun-wa; Danielson, U. Helena; Egner, Ursula et al.

Ingår i Nature reviews. Drug discovery, s. 679-698, 2016

• DOI för Biophysics in drug discovery: impact, challenges and opportunities

Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

Danielson, U. Helena

Ingår i Multifaceted Roles Of Crystallography In Modern Drug Discovery, s. 223-240, 2015

• DOI för Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

MIV-170: A novel NNRTI exhibiting tight binding to HIV-1 reverse transcriptase (RT)

Elinder, Malin; Danielson, Helena; Unge, Torsten; VanHam, Guido et al.

2008

• DOI för MIV-170: A novel NNRTI exhibiting tight binding to HIV-1 reverse transcriptase (RT)

Investigation of beta-amino acids as building blocks in hepatitis c virus NS3 protease inhibitors

Nurbo, Johanna; Dahl, G; Danielson, U Helena; Sandström, Anja

2007

Novel C-terminal functionalities in hepatitis C virus NS3 protease inhibitors

Rönn, Robert; Gossas, T; Sabnis, Y A; Åkerblom, E et al.

2005

Optimisation of peptide-based inhibitors of full-length hepatitis C virus NS3 protease

Poliakov, Anton; Johansson, A; Åkerblom, E; Lindeberg, G et al.

2004

Identification of complexities in HIV-1 protease - ligand interactions using biosensor technology

Lindgren, Maria T.; Shuman, Cynthia F.; Hämäläinen, Markku; Karlsson, R. et al.

Discovery of the subsite specificity of Candida albicans Sap1 and Sap2 and the design of potent peptidomimetic inhibitors

Rubin, Jamie E.; Beyer, Bret B.; Chung, Alfred Y.; Johnson, Jodie V. et al.

Substrate specificity and pH dependence of secreted aspartic proteases Sap1, Sap2 and Sap3 from Candida albicans

Backman, Dan; Danielson, U. Helena

Initial evaluation of biotinylated bilayer disks as model membranes for biosensor analyses

Lundquist, Anna; Hansen, Soren B.; Nordström, Helena; Danielson, Helena et al.

Kinetic, mechanistic and chemodynamic characterisation of non-nucleoside hepatitis C virus NS5B polymerase inhibitors using SPR biosensor technology

Geitmann, Matthis; Dahl, Göran; Lohmann, Volker; Paeshuyse, Jan et al.

Kinetic characterization of HCV NS3 inhibitors using an SPR biosensor

Geitmann, Matthis; Dahl, Göran; Danielson, Helena

Efficient protein binders for the C-reactive protein from a designed chemically modified peptide library

T. Tegler, Lotta; Nonglaton, Guillaume; Büttner, Frank; Karin, Caldwell et al.

Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ

Al-Amin, Rasel A.; Johansson, Lars; Landegren, Nils; Löf, Liza et al.

Multiplexed biosensor-based screening and structural assessment of fragments targeting KLHL12 and KLHL20

Myers, Nadine; Koehler, Konrad; Diallo, Marcel; Xiong, Ruisheng et al.

Design of a Stapled Peptide Targeting KLHL20^Kelch: A Computational and Biosensor-based Approach

Myers, Nadine; Cadot, Marie Elodie Helene; Varga, Julia; Diallo, Marcel et al.

Deciphering the RNA recognition by Musashi-1 to design protein and RNA mutants for in vitro and in vivo applications

Pérez-Ràfols, Anna; Pérez-Ropero, Guillermo; Cerofolini, Linda; Sperotto, Luca et al.

• DOI för Deciphering the RNA recognition by Musashi-1 to design protein and RNA mutants for in vitro and in vivo applications

Exploring real-time interaction analysis to monitor CD44 expression modulation in cancer cells by inhibiting Musashi-1 interactions with RNA

Pérez-Ropero, Guillermo; Ortstad, Nathalie; Nestor, Marika; Danielson, Helena et al.