Oommen Varghese group

Translational chemical biology laboratory
Ongoing research in Varghese Group
We work at the interface of chemistry and biology. We design novel synthetic strategies for developing functional biomaterials and novel nucleic acid-based precision medicine drugs for translational medicine.
We have a multidisciplinary team with experience in synthetic organic chemistry, cell and molecular biology, material science and clinical research. Such a unique interdisciplinary environment allows us to perform research at the highest level with synergies between scientists from different domains of science. We believe in science without any boundaries and therefore encourage our team members to make bold steps and venture into untested waters.
This result in an exceptional team environment where chemists perform biological experiments and biologist participate in pre-clinical research. We also have close collaborations with Uppsala University hospital and leading researchers across Europe and Asia. Broadly, our research could be categorised into four different areas that are closely interconnected.
To lear more about about our ongoing research, see the following projects:
- Synthetic Organic Chemistry
- Nucleic Acid Therapeutics
- Regenerative Medicine
- Anticancer Therapy
Group members
Publications
Part of Biomimetics, 2024
- DOI for Physically and Chemically Crosslinked Hyaluronic Acid-Based Hydrogels Differentially Promote Axonal Outgrowth from Neural Tissue Cultures
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A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels
Part of Carbohydrate Polymers, 2024
- DOI for A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels
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Fine-tuning Dynamic Cross-linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels
Part of Advanced Functional Materials, 2024
- DOI for Fine-tuning Dynamic Cross-linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels
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Part of Advanced NanoBiomed Research, 2023
- DOI for Advances in Intracellular and On-Surface Polymerization in Living Cells: Implications for Nanobiomedicines
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Part of Biomaterials Advances, 2023
- DOI for Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function
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Unveiling extracellular matrix assembly: Insights and approaches through bioorthogonal chemistry
Part of MATERIALS TODAY BIO, 2023
- DOI for Unveiling extracellular matrix assembly: Insights and approaches through bioorthogonal chemistry
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Part of Advanced Therapeutics, 2022
- DOI for Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model
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Part of Acta Biomaterialia, p. 36-48, 2022
- DOI for Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype
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Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications
Part of Biomaterials Science, p. 6399-6412, 2022
- DOI for Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications
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Effect of the Addition Frequency of 5-Azacytidine in Both Micro- and Macroscale Cultures
Part of Cellular and Molecular Bioengineering, p. 121-130, 2021
- DOI for Effect of the Addition Frequency of 5-Azacytidine in Both Micro- and Macroscale Cultures
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Part of Biomaterials Science, p. 3939-3944, 2021
- DOI for Redox responsive Pluronic micelle mediated delivery of functional siRNA: a modular nano-assembly for targeted delivery
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Discrepancies on the Role of Oxygen Gradient and Culture Condition on Mesenchymal Stem Cell Fate
Part of Advanced Healthcare Materials, 2021
- DOI for Discrepancies on the Role of Oxygen Gradient and Culture Condition on Mesenchymal Stem Cell Fate
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Part of Polymer Chemistry, p. 2987-2991, 2021
- DOI for An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels
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PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Part of Organs-on-a-Chip, 2020
- DOI for PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
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Part of Biomacromolecules, p. 1412-1420, 2019
Part of ACS Applied Materials and Interfaces, p. 38232-38239, 2019
Part of Biosensors & bioelectronics, p. 188-193, 2019
Synthetic design of asymmetric miRNA with engineered 3′-overhang to improve strand selection
Part of Molecular Therapy Nucleic Acids, p. 597-604, 2019
- DOI for Synthetic design of asymmetric miRNA with engineered 3′-overhang to improve strand selection
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Part of Sensors and actuators. B, Chemical, 2019
Part of Chemical Communications, p. 9112-9115, 2019
- DOI for 4 '-Guanidinium-modified siRNA: a molecular tool to control RNAi activity through RISC priming and selective antisense strand loading
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Part of International Journal of Molecular Sciences, 2019
- DOI for Innovative strategy for 3D transfection of primary human stem cells with BMP-2 expressing plasmid DNA: A clinically translatable strategy for ex vivogene therapy
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Part of Biomacromolecules, p. 1317-1324, 2019
Part of Angewandte Chemie International Edition, p. 2815-2819, 2019
Part of ACS Applied Bio Materials, 2019
Part of Polymer Chemistry, p. 4322-4327, 2019
- DOI for Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels
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Part of Chemical Communications, p. 12507-12510, 2018
- DOI for Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH
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Bi-directional cell-pericellular matrix interactions direct stem cell fate
Part of Nature Communications, 2018
- DOI for Bi-directional cell-pericellular matrix interactions direct stem cell fate
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Saline Accelerates Oxime Reaction with Aldehyde and Keto Substrates at Physiological pH
Part of Scientific Reports, 2018
- DOI for Saline Accelerates Oxime Reaction with Aldehyde and Keto Substrates at Physiological pH
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Part of Biomaterials, p. 190-202, 2018
Part of RSC Advances, p. 31980-31988, 2017
- DOI for Injectable and thermoresponsive pericardial matrix derived conductive scaffold for cardiac tissue engineering
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Part of Regenerative Medicine, p. 525-539, 2017
Part of Chemical Communications, p. 966-969, 2016
Part of ACS Applied Materials and Interfaces, p. 20614-20624, 2016
Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery
Part of Biomaterials Science, p. 1310-1313, 2016
Part of RSC Advances, p. 12257-12260, 2015
Insights into the Mechanism and Catalysis of Oxime Coupling Chemistry at Physiological pH
Part of Chemistry - A European Journal, p. 5980-5985, 2015
Part of Advanced Functional Materials, p. 3907-3915, 2015
Part of Macromolecular Bioscience, p. 327-333, 2014
Part of European Journal of Pharmaceutical Sciences, p. 35-44, 2014
Part of Advanced Functional Materials, p. 1273-1280, 2013
PLGA/PEG-hydrogel composite scaffolds with controllable mechanical properties
Part of Journal of Biomedical Materials Research. Part B - Applied biomaterials, p. 648-655, 2013
Part of Biomacromolecules, p. 2427-2432, 2013
Critical assessment of rhBMP-2 mediated bone induction: An in vitro and in vivo evaluation.
Part of Journal of Controlled Release, p. 646-653, 2012
Minimally invasive mandibular bone augmentation using injectable hydrogels
Part of Journal of Tissue Engineering and Regenerative Medicine, 2012
Injectable hyaluronic acid hydrogel for bone tissue engineering
Part of European Cells & Materials, p. 2, 2012
Bone reservoir: Injectable hyaluronic acid hydrogel for minimal invasive bone augmentation
Part of Journal of Controlled Release, p. 232-240, 2011
Part of Biomacromolecules, p. 2247-2254, 2010
Modular approach to functional hyaluronic acid hydrogels using orthogonal chemical reactions
Part of Chemical Communications, p. 8368-8370, 2010
Synthesis of Guanidinium-Modified Hyaluronic Acid Hydrogel
Part of Macromolecular rapid communications, p. 1175-1180, 2010
Part of Journal of the American Chemical Society, p. 8781-8783, 2009