Gunilla Enblad – Tumour biology and clinical studies of lymphomas and prostate cancer
In our projects we study different types of lymphomas, i.e. diffuse large B-cell lymphoma, Hodgkin lymphoma and follicular lymphoma, and prostate cancer. Our goal is to increase the knowledge about the biology behind the diseases and how afflicted patients can be treated in the best way. We also want to contribute to the development of new, improved treatment strategies.
Lymphomas are a group of tumours that originate from the lymph system and where white blood cells grow in an uncontrolled way. There are several types of lymphoma that can be more or less aggressive.
Diffuse large B-cell lymphoma is one of the most common types of lymphoma. It is an aggressive type and patients that are not treated have a short survival. Hodgkin lymphoma is less common but often affect younger patients and has a good prognosis. However, late side effects of treatment are a threat to the patient’s health. Mantle cell lymphoma is a very aggressive lymphoma with a poor prognosis.
Our projects on prostate cancer and ovarian cancer include clinical and biological studies of the diseases.

Photo: Axel Henriksson
Publications
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Part of Blood Advances, p. 4889-4897, 2026
- DOI for AVD is an effective chemotherapy backbone in first-line treatment of older patients with classical Hodgkin lymphoma
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Part of Blood Cancer Journal, 2026
- DOI for Clonal hematopoiesis of indeterminate potential in high grade B-cell lymphomas: clinicobiological associations and further insight with single-cell multiomics analysis
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Exploratory study linking plasma proteomics to cardiotoxicity in Hodgkin lymphoma
Part of Cardio-Oncology, 2026
- DOI for Exploratory study linking plasma proteomics to cardiotoxicity in Hodgkin lymphoma
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Part of Leukemia and Lymphoma, p. 1327-1334, 2026
- DOI for Neoehrlichia mikurensis infection associated with lymphoma or mimicking lymphoma in two cohorts of Swedish patients
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Part of HemaSphere, 2025
- DOI for Development of myeloid neoplasia associated with prolonged immune cell-associated hematotoxicity after CAR T-cell treatment of B-cell lymphoma: Should we surveille for pre-existing myeloid mutations?
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Part of Clinical Immunology, 2025
- DOI for Diffuse large B cell lymphoma in rheumatoid arthritis patients is associated with elevated B-cell driving factors including CXCL13
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Part of Leukemia, p. 1256-1259, 2025
- DOI for Implementation of standard of care CAR-T-cell treatment for patients with aggressive B-cell lymphoma and acute lymphoblastic leukemia in Sweden
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Part of Cancer Immunology and Immunotherapy, 2025
- DOI for Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
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Part of European Urology Oncology, p. 1486-1495, 2025
- DOI for Prognostic Value of the Circulating Tumor DNA Fraction in Metastatic Castration-resistant Prostate Cancer: Results from the ProBio Platform Trial
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Part of Nature Communications, 2025
- DOI for scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
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Part of British Journal of Haematology, p. 1834-1839, 2025
- DOI for Temporal trends in relative survival of diffuse large B-cell lymphoma in Sweden and Denmark in the era of targeted and cellular therapies
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Part of Nature Medicine, 2024
- DOI for Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial
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Part of Cancer Causes and Control, p. 1101-1109, 2024
- DOI for Association between parity and pregnancy-associated tumor features in high-grade serous ovarian cancer
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Part of British Journal of Haematology, p. 1794-1803, 2024
- DOI for Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers
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Part of Leukemia, p. 438-441, 2024
- DOI for Genetic and transcriptomic analyses of diffuse large B-cell lymphoma patients with poor outcomes within two years of diagnosis
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Part of Heliyon, 2024
- DOI for Improved automated tumor segmentation in whole-body 3D scans using multi-directional 2D projection-based priors
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Long-Term Follow-Up of the Response-Adjusted Therapy for Advanced Hodgkin Lymphoma Trial
Part of Journal of Clinical Oncology, p. 13-18, 2024
- DOI for Long-Term Follow-Up of the Response-Adjusted Therapy for Advanced Hodgkin Lymphoma Trial
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Part of Leukemia and Lymphoma, p. 534-537, 2024
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The National Swedish Lymphoma Register - a systematic validation of data quality
Part of Acta Oncologica, p. 563-572, 2024
- DOI for The National Swedish Lymphoma Register - a systematic validation of data quality
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Part of eJHaem, p. 516-526, 2024
- DOI for Treatment sequencing and impact of number of treatment lines on survival in follicular lymphoma: A national population-based study
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A whole-body diffusion MRI normal atlas: development, evaluation and initial use
Part of Cancer Imaging, 2023
- DOI for A whole-body diffusion MRI normal atlas: development, evaluation and initial use
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ADAR1-mediated RNA editing promotes B cell lymphomagenesis
Part of iScience, 2023
- DOI for ADAR1-mediated RNA editing promotes B cell lymphomagenesis
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Next generation pan-cancer blood proteome profiling using proximity extension assay
Part of Nature Communications, 2023
- DOI for Next generation pan-cancer blood proteome profiling using proximity extension assay
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Part of Cancers, 2023
- DOI for Sex- and Female Age-Dependent Differences in Gene Expression in Diffuse Large B-Cell Lymphoma-Possible Estrogen Effects
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Part of Clinical Cancer Research, p. 4139-4152, 2023
- DOI for Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
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Part of Blood Advances, p. 5304-5313, 2023
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Part of Acta Oncologica, p. 1707-1715, 2023
- DOI for Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2
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Part of HemaSphere, 2023
- DOI for Survival by First-line Treatment Type and Timing of Progression Among Follicular Lymphoma Patients: A National Population-based Study in Sweden
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Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma
Part of Journal of Clinical Investigation, 2023
- DOI for Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma
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Advances in immune therapies in hematological malignancies
Part of Journal of Internal Medicine, p. 205-220, 2022
- DOI for Advances in immune therapies in hematological malignancies
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Checkpoint CD47 expression in classical Hodgkin lymphoma
Part of British Journal of Haematology, p. 580-589, 2022
- DOI for Checkpoint CD47 expression in classical Hodgkin lymphoma
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COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients
Part of Pediatric Blood & Cancer, 2022
- DOI for COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients
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Part of PLOS ONE, 2022
- DOI for Donor-derived urologic cancers after renal transplantation: A retrospective non-randomized scientific analysis
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Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue
Part of Cancers, 2022
- DOI for Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue
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Part of Journal of Clinical Oncology, p. 1487-1496, 2022
- DOI for Limited, But Not Eliminated, Excess Long-Term Morbidity in Stage I-IIA Hodgkin Lymphoma Treated With Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine and Limited-Field Radiotherapy
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Noninvasive detection of any-stage cancer using free glycosaminoglycans
Part of Proceedings of the National Academy of Sciences of the United States of America, 2022
- DOI for Noninvasive detection of any-stage cancer using free glycosaminoglycans
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Outcome in PCNSL patients and its association with PD-L1+leukocytes in the tumor microenvironment
Part of Acta Oncologica, p. 824-829, 2022
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Part of British Journal of Haematology, p. 267-277, 2022
- DOI for Outcomes of relapsed/refractory diffuse large B-cell lymphoma and influence of chimaeric antigen receptor T trial eligibility criteria in second line-A population-based study of 736 patients
- Download full text (pdf) of Outcomes of relapsed/refractory diffuse large B-cell lymphoma and influence of chimaeric antigen receptor T trial eligibility criteria in second line-A population-based study of 736 patients
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Part of International Journal of Cancer, p. 773-781, 2022
- DOI for Parity is associated with better prognosis in ovarian germ cell tumors, but not in other ovarian cancer subtypes
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Part of Blood, p. 2248-2260, 2022
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Part of New Biotechnology, p. 21-29, 2022
- DOI for Plasma protein biomarker profiling reveals major differences between acute leukaemia, lymphoma patients and controls
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The dual role of CD70 in B‐cell lymphomagenesis
Part of Clinical and Translational Medicine, 2022
- DOI for The dual role of CD70 in B‐cell lymphomagenesis
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Part of Genes, Chromosomes and Cancer, p. 27-36, 2022
- DOI for Transcriptome sequencing of archived lymphoma specimens is feasible and clinically relevant using exome capture technology
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Part of Cancer Imaging, 2022
- DOI for Whole body FDG PET/MR for progression free and overall survival prediction in patients with relapsed/refractory large B-cell lymphomas undergoing CAR T-cell therapy
- Download full text (pdf) of Whole body FDG PET/MR for progression free and overall survival prediction in patients with relapsed/refractory large B-cell lymphomas undergoing CAR T-cell therapy
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Part of British Journal of Haematology, p. 906-914, 2021
- DOI for Age is the most important predictor of survival in diffuse large B-cell lymphoma patients achieving event-free survival at 24 months: a Swedish population-based study
- Download full text (pdf) of Age is the most important predictor of survival in diffuse large B-cell lymphoma patients achieving event-free survival at 24 months: a Swedish population-based study
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Part of Cancer Immunology and Immunotherapy, p. 2851-2865, 2021
- DOI for Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy
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Part of Acta Oncologica, p. 1459-1465, 2021
- DOI for Clinical characteristics and factors associated with COVID-19-related death and morbidity among hospitalized patients with cancer: a Swedish cohort study
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Part of Upsala Journal of Medical Sciences, 2021
- DOI for High risk of cardiovascular side effects after treatment of Hodgkin's lymphoma - is there a need for intervention in long-term survivors?
- Download full text (pdf) of High risk of cardiovascular side effects after treatment of Hodgkin's lymphoma - is there a need for intervention in long-term survivors?
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Part of Blood Cancer Journal, 2021
- DOI for Incidence of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) including CNS relapse in a population-based cohort of 4243 patients in Sweden
- Download full text (pdf) of Incidence of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) including CNS relapse in a population-based cohort of 4243 patients in Sweden
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Part of Acta Oncologica, p. 531-538, 2021
- DOI for PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS
- Download full text (pdf) of PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS
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Plasma proteome profiling of cardiotoxicity in patients with diffuse large B-cell lymphoma
Part of Cardio-Oncology, 2021
- DOI for Plasma proteome profiling of cardiotoxicity in patients with diffuse large B-cell lymphoma
- Download full text (pdf) of Plasma proteome profiling of cardiotoxicity in patients with diffuse large B-cell lymphoma
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Prior antithymocyte globulin therapy and survival in post-transplant lymphoproliferative disorders
Part of Acta Oncologica, p. 771-778, 2021
- DOI for Prior antithymocyte globulin therapy and survival in post-transplant lymphoproliferative disorders
- Download full text (pdf) of Prior antithymocyte globulin therapy and survival in post-transplant lymphoproliferative disorders
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Prognostic impact of soluble CD163 in patients with diffuse large B-cell lymphoma
Part of Haematologica, p. 2502-2506, 2021
- DOI for Prognostic impact of soluble CD163 in patients with diffuse large B-cell lymphoma
- Download full text (pdf) of Prognostic impact of soluble CD163 in patients with diffuse large B-cell lymphoma
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Revisiting IL-6 expression in the tumor microenvironment of classical Hodgkin lymphoma
Part of Blood Advances, p. 1671-1681, 2021
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Part of Upsala Journal of Medical Sciences, 2021
- DOI for Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma
- Download full text (pdf) of Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma
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Part of British Journal of Haematology, p. 568-579, 2021
- DOI for Superior outcome for splenectomised patients in a population-based study of splenic marginal zone lymphoma in Sweden
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CD30 expression and survival in posttransplant lymphoproliferative disorders
Part of Acta Oncologica, p. 673-680, 2020
- DOI for CD30 expression and survival in posttransplant lymphoproliferative disorders
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Clonal hematopoiesis in patients with high-grade B-cell lymphoma is associated with inferior outcome
Part of American Journal of Hematology, 2020
- DOI for Clonal hematopoiesis in patients with high-grade B-cell lymphoma is associated with inferior outcome
- Download full text (pdf) of Clonal hematopoiesis in patients with high-grade B-cell lymphoma is associated with inferior outcome
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Marginal zone lymphoma expression of histidine-rich glycoprotein correlates with improved survival
Part of eJHaem, p. 199-207, 2020
- DOI for Marginal zone lymphoma expression of histidine-rich glycoprotein correlates with improved survival
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Part of British Journal of Haematology, p. 685-691, 2020
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Part of American Journal of Hematology, p. 740-748, 2020
- DOI for Outcome and determinants of failure to complete primary R-CHOP treatment for reasons other than non-response among patients with diffuse large B-cell lymphoma
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Part of Immunobiology, 2020
- DOI for Precursor cells and implications of a T-cell inflamed immune response in the pre-malignant setting in Hodgkin lymphoma
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Prognostic impact of abdominal lymph node involvement in diffuse large B-cell lymphoma
Part of European Journal of Haematology, p. 207-213, 2020
- DOI for Prognostic impact of abdominal lymph node involvement in diffuse large B-cell lymphoma
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Part of Transplant International, p. 1700-1710, 2020
- DOI for Relative and absolute cancer risks among Nordic kidney transplant recipients-a population-based study
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Part of Trials, 2020
- DOI for The ProBio trial: molecular biomarkers for advancing personalized treatment decision in patients with metastatic castration-resistant prostate cancer
- Download full text (pdf) of The ProBio trial: molecular biomarkers for advancing personalized treatment decision in patients with metastatic castration-resistant prostate cancer
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Tumor endothelial ELTD1 as a predictive marker for treatment of renal cancer patients with sunitinib
Part of BMC Cancer, 2020
- DOI for Tumor endothelial ELTD1 as a predictive marker for treatment of renal cancer patients with sunitinib
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Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients
Part of BMC Cancer, 2019
- DOI for Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients
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Autoimmune disease in patients with diffuse large B-cell lymphoma: occurrence and impact on outcome
Part of Acta Oncologica, p. 1170-1177, 2019
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Part of Leukemia and Lymphoma, p. 376-384, 2019
- DOI for Expression of PD-1, PD-L1, and PD-L2 in posttransplant lymphoproliferative disorder after solid organ transplantation
- Download full text (pdf) of Expression of PD-1, PD-L1, and PD-L2 in posttransplant lymphoproliferative disorder after solid organ transplantation
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Part of British Journal of Haematology, p. 431-439, 2019
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Part of British Journal of Haematology, p. 192-201, 2019
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Part of Acta Oncologica, p. 1655-1659, 2019
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Part of Journal of Cancer, p. 3224-3231, 2019
- DOI for Tumoral pyruvate kinase L/R as a predictive marker for the treatment of renal cancer patients with sunitinib and sorafenib
- Download full text (pdf) of Tumoral pyruvate kinase L/R as a predictive marker for the treatment of renal cancer patients with sunitinib and sorafenib
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A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia
Part of Clinical Cancer Research, p. 6185-6194, 2018
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Part of European Journal of Haematology, p. 88-97, 2018
- DOI for An anergic immune signature in the tumor microenvironment of classical Hodgkin lymphoma is associated with inferior outcome
- Download full text (pdf) of An anergic immune signature in the tumor microenvironment of classical Hodgkin lymphoma is associated with inferior outcome
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Part of Annals of Hematology, p. 2129-2135, 2018
- DOI for Does the omission of vincristine in patients with diffuse large B cell lymphoma affect treatment outcome?
- Download full text (pdf) of Does the omission of vincristine in patients with diffuse large B cell lymphoma affect treatment outcome?
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Part of PLOS ONE, 2018
- DOI for Expression of PD-1 and PD-L1 increase in consecutive biopsies in patients with classical Hodgkin lymphoma
- Download full text (pdf) of Expression of PD-1 and PD-L1 increase in consecutive biopsies in patients with classical Hodgkin lymphoma
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Part of British Journal of Haematology, p. 770-781, 2018
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Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018
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Part of Blood, 2018
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Part of European Journal of Haematology, p. 61-68, 2018
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Part of American Journal of Hematology, p. 1020-1028, 2018
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Part of Blood, 2018
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Part of Annals of Oncology, p. 1882-1883, 2018
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Part of Acta Oncologica, p. 187-194, 2018
- DOI for U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
- Download full text (pdf) of U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
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Part of Acta Oncologica, p. 106-109, 2017
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Part of Annals of Oncology, 2017
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Donor Derived and BK Virus Positive Urologic Cancers After Renal Transplantation
Part of American Journal of Transplantation, p. 472-472, 2017
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Estrogen receptor beta 1 in diffuse large B-cell lymphoma growth and as a prognostic biomarker
Part of Leukemia and Lymphoma, p. 418-427, 2017
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Expression of possible targets for new proteasome inhibitors in diffuse large B-cell lymphoma
Part of European Journal of Haematology, p. 52-56, 2017
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High posttransplant cancer incidence in renal transplanted patients with pretransplant cancer
Part of Transplantation, p. 1295-1302, 2017
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Part of Blood Advances, p. 1427-1439, 2017
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Immunological biomarkers correlate to survival in CAR19-treated patients
Part of Scandinavian Journal of Immunology, p. 337-337, 2017
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Part of Acta Oncologica, p. 599-607, 2017
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Part of Acta Dermato-Venereologica, p. 751-753, 2017
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Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients
Part of Journal of Cancer, p. 3975-3983, 2017
- DOI for Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients
- Download full text (pdf) of Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients
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Part of Journal of Cancer Research and Clinical Oncology, p. 961-970, 2017
- DOI for Tumoral cubilin is a predictive marker for treatment of renal cancer patients with sunitinib and sorafenib
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Part of Molecular Therapy, 2016
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Part of Acta Oncologica, p. 1126-1131, 2016
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Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin's Lymphoma
Part of New England Journal of Medicine, p. 2419-2429, 2016