Gunilla Enblad – Tumour biology and clinical studies of lymphomas and prostate cancer
In our projects we study different types of lymphomas, i.e. diffuse large B-cell lymphoma, Hodgkin lymphoma and follicular lymphoma, and prostate cancer. Our goal is to increase the knowledge about the biology behind the diseases and how afflicted patients can be treated in the best way. We also want to contribute to the development of new, improved treatment strategies.
Lymphomas are a group of tumours that originate from the lymph system and where white blood cells grow in an uncontrolled way. There are several types of lymphoma that can be more or less aggressive.
Diffuse large B-cell lymphoma is one of the most common types of lymphoma. It is an aggressive type and patients that are not treated have a short survival. Hodgkin lymphoma is less common but often affect younger patients and has a good prognosis. However, late side effects of treatment are a threat to the patient’s health. Mantle cell lymphoma is a very aggressive lymphoma with a poor prognosis.
Our projects on prostate cancer and ovarian cancer include clinical and biological studies of the diseases.
Group members
Publications
Part of Leukemia, p. 438-441, 2024
Part of Heliyon, 2024
Long-Term Follow-Up of the Response-Adjusted Therapy for Advanced Hodgkin Lymphoma Trial
Part of Journal of Clinical Oncology, p. 13-18, 2024
Part of Leukemia and Lymphoma, p. 534-537, 2024
The National Swedish Lymphoma Register - a systematic validation of data quality
Part of Acta Oncologica, p. 563-572, 2024
Part of eJHaem, p. 516-526, 2024
A whole-body diffusion MRI normal atlas: development, evaluation and initial use
Part of Cancer Imaging, 2023
ADAR1-mediated RNA editing promotes B cell lymphomagenesis
Part of iScience, 2023
Next generation pan-cancer blood proteome profiling using proximity extension assay
Part of Nature Communications, 2023
Part of Cancers, 2023
Part of Clinical Cancer Research, p. 4139-4152, 2023
- DOI for Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
- Download full text (pdf) of Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
Part of Blood Advances, p. 5304-5313, 2023
Part of Acta Oncologica, p. 1707-1715, 2023
- DOI for Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2
- Download full text (pdf) of Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2
Part of HemaSphere, 2023
- DOI for Survival by First-line Treatment Type and Timing of Progression Among Follicular Lymphoma Patients: A National Population-based Study in Sweden
- Download full text (pdf) of Survival by First-line Treatment Type and Timing of Progression Among Follicular Lymphoma Patients: A National Population-based Study in Sweden
Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma
Part of Journal of Clinical Investigation, 2023
Advances in immune therapies in hematological malignancies
Part of Journal of Internal Medicine, p. 205-220, 2022
Checkpoint CD47 expression in classical Hodgkin lymphoma
Part of British Journal of Haematology, p. 580-589, 2022
COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients
Part of Pediatric Blood & Cancer, 2022
Part of PLOS ONE, 2022
Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue
Part of Cancers, 2022
Part of Journal of Clinical Oncology, p. 1487-1496, 2022
- DOI for Limited, But Not Eliminated, Excess Long-Term Morbidity in Stage I-IIA Hodgkin Lymphoma Treated With Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine and Limited-Field Radiotherapy
- Download full text (pdf) of Limited, But Not Eliminated, Excess Long-Term Morbidity in Stage I-IIA Hodgkin Lymphoma Treated With Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine and Limited-Field Radiotherapy
Noninvasive detection of any-stage cancer using free glycosaminoglycans
Part of Proceedings of the National Academy of Sciences of the United States of America, 2022
Outcome in PCNSL patients and its association with PD-L1+leukocytes in the tumor microenvironment
Part of Acta Oncologica, p. 824-829, 2022
Part of British Journal of Haematology, p. 267-277, 2022
- DOI for Outcomes of relapsed/refractory diffuse large B-cell lymphoma and influence of chimaeric antigen receptor T trial eligibility criteria in second line-A population-based study of 736 patients
- Download full text (pdf) of Outcomes of relapsed/refractory diffuse large B-cell lymphoma and influence of chimaeric antigen receptor T trial eligibility criteria in second line-A population-based study of 736 patients
Part of International Journal of Cancer, p. 773-781, 2022
Part of Blood, p. 2248-2260, 2022
Part of New Biotechnology, p. 21-29, 2022
The dual role of CD70 in B‐cell lymphomagenesis
Part of Clinical and Translational Medicine, 2022
Part of Genes, Chromosomes and Cancer, p. 27-36, 2022
Part of Cancer Imaging, 2022
- DOI for Whole body FDG PET/MR for progression free and overall survival prediction in patients with relapsed/refractory large B-cell lymphomas undergoing CAR T-cell therapy
- Download full text (pdf) of Whole body FDG PET/MR for progression free and overall survival prediction in patients with relapsed/refractory large B-cell lymphomas undergoing CAR T-cell therapy
Part of British Journal of Haematology, p. 906-914, 2021
- DOI for Age is the most important predictor of survival in diffuse large B-cell lymphoma patients achieving event-free survival at 24 months: a Swedish population-based study
- Download full text (pdf) of Age is the most important predictor of survival in diffuse large B-cell lymphoma patients achieving event-free survival at 24 months: a Swedish population-based study
Part of Cancer Immunology and Immunotherapy, p. 2851-2865, 2021
Part of Acta Oncologica, p. 1459-1465, 2021
- DOI for Clinical characteristics and factors associated with COVID-19-related death and morbidity among hospitalized patients with cancer: a Swedish cohort study
- Download full text (pdf) of Clinical characteristics and factors associated with COVID-19-related death and morbidity among hospitalized patients with cancer: a Swedish cohort study
Part of Upsala Journal of Medical Sciences, 2021
- DOI for High risk of cardiovascular side effects after treatment of Hodgkin's lymphoma - is there a need for intervention in long-term survivors?
- Download full text (pdf) of High risk of cardiovascular side effects after treatment of Hodgkin's lymphoma - is there a need for intervention in long-term survivors?
Part of Blood Cancer Journal, 2021
- DOI for Incidence of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) including CNS relapse in a population-based cohort of 4243 patients in Sweden
- Download full text (pdf) of Incidence of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) including CNS relapse in a population-based cohort of 4243 patients in Sweden
Part of Acta Oncologica, p. 531-538, 2021
Plasma proteome profiling of cardiotoxicity in patients with diffuse large B-cell lymphoma
Part of Cardio-Oncology, 2021
Prior antithymocyte globulin therapy and survival in post-transplant lymphoproliferative disorders
Part of Acta Oncologica, p. 771-778, 2021
Prognostic impact of soluble CD163 in patients with diffuse large B-cell lymphoma
Part of Haematologica, p. 2502-2506, 2021
Revisiting IL-6 expression in the tumor microenvironment of classical Hodgkin lymphoma
Part of Blood Advances, p. 1671-1681, 2021
Part of Upsala Journal of Medical Sciences, 2021
Part of British Journal of Haematology, p. 568-579, 2021
CD30 expression and survival in posttransplant lymphoproliferative disorders
Part of Acta Oncologica, p. 673-680, 2020
Clonal hematopoiesis in patients with high-grade B-cell lymphoma is associated with inferior outcome
Part of American Journal of Hematology, 2020
Marginal zone lymphoma expression of histidine-rich glycoprotein correlates with improved survival
Part of eJHaem, p. 199-207, 2020
Part of British Journal of Haematology, p. 685-691, 2020
Part of American Journal of Hematology, p. 740-748, 2020
- DOI for Outcome and determinants of failure to complete primary R-CHOP treatment for reasons other than non-response among patients with diffuse large B-cell lymphoma
- Download full text (pdf) of Outcome and determinants of failure to complete primary R-CHOP treatment for reasons other than non-response among patients with diffuse large B-cell lymphoma
Part of Immunobiology, 2020
Prognostic impact of abdominal lymph node involvement in diffuse large B-cell lymphoma
Part of European Journal of Haematology, p. 207-213, 2020
Part of Transplant International, p. 1700-1710, 2020
Part of Trials, 2020
- DOI for The ProBio trial: molecular biomarkers for advancing personalized treatment decision in patients with metastatic castration-resistant prostate cancer
- Download full text (pdf) of The ProBio trial: molecular biomarkers for advancing personalized treatment decision in patients with metastatic castration-resistant prostate cancer
Tumor endothelial ELTD1 as a predictive marker for treatment of renal cancer patients with sunitinib
Part of BMC Cancer, 2020
Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients
Part of BMC Cancer, 2019
Autoimmune disease in patients with diffuse large B-cell lymphoma: occurrence and impact on outcome
Part of Acta Oncologica, p. 1170-1177, 2019
Part of Leukemia and Lymphoma, p. 376-384, 2019
Part of British Journal of Haematology, p. 431-439, 2019
Part of British Journal of Haematology, p. 192-201, 2019
Part of Acta Oncologica, p. 1655-1659, 2019
Part of Journal of Cancer, p. 3224-3231, 2019
A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia
Part of Clinical Cancer Research, p. 6185-6194, 2018
Part of European Journal of Haematology, p. 88-97, 2018
Part of Annals of Hematology, p. 2129-2135, 2018
Part of PLOS ONE, 2018
Part of British Journal of Haematology, p. 770-781, 2018
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018
Part of Blood, 2018
Part of European Journal of Haematology, p. 61-68, 2018
Part of American Journal of Hematology, p. 1020-1028, 2018
Part of Blood, 2018
Part of Annals of Oncology, p. 1882-1883, 2018
Part of Acta Oncologica, p. 187-194, 2018
Part of Acta Oncologica, p. 106-109, 2017
Part of Annals of Oncology, 2017
Donor Derived and BK Virus Positive Urologic Cancers After Renal Transplantation
Part of American Journal of Transplantation, p. 472-472, 2017
Estrogen receptor beta 1 in diffuse large B-cell lymphoma growth and as a prognostic biomarker
Part of Leukemia and Lymphoma, p. 418-427, 2017
Expression of possible targets for new proteasome inhibitors in diffuse large B-cell lymphoma
Part of European Journal of Haematology, p. 52-56, 2017
High posttransplant cancer incidence in renal transplanted patients with pretransplant cancer
Part of Transplantation, p. 1295-1302, 2017
Part of Blood Advances, p. 1427-1439, 2017
Immunological biomarkers correlate to survival in CAR19-treated patients
Part of Scandinavian Journal of Immunology, p. 337-337, 2017
Part of Acta Oncologica, p. 599-607, 2017
Part of Acta Dermato-Venereologica, p. 751-753, 2017
Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients
Part of Journal of Cancer, p. 3975-3983, 2017
Part of Journal of Cancer Research and Clinical Oncology, p. 961-970, 2017
Part of Molecular Therapy, 2016
Part of Acta Oncologica, p. 1126-1131, 2016
Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin's Lymphoma
Part of New England Journal of Medicine, p. 2419-2429, 2016
Part of CANCER IMMUNOLOGY RESEARCH, 2016
Part of British Journal of Haematology, p. 614-622, 2016
Diffuse Large B Cell Lymphoma Cell Line U2946: Model for MCL1 Inhibitor Testing
Part of PLOS ONE, 2016
Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
Part of Blood, p. 2666-2670, 2016
Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas
Part of Blood, p. 3026-3034, 2016
Part of Haematologica, p. 1-2, 2016
In vitro and in vivo activity of melflufen (J1) in lymphoma
Part of BMC Cancer, 2016
Part of Acta Oncologica, p. 774-781, 2016
Part of Haematologica, p. 3-3, 2016
Part of Haematologica, p. 42-42, 2016
Part of European Journal of Haematology, p. 430-438, 2016
- DOI for The role of tumour-infiltrating eosinophils, mast cells and macrophages in Classical and Nodular Lymphocyte Predominant Hodgkin Lymphoma in children
- Download full text (pdf) of The role of tumour-infiltrating eosinophils, mast cells and macrophages in Classical and Nodular Lymphocyte Predominant Hodgkin Lymphoma in children
CAR T-Cell Therapy: The Role of Physical Barriers and Immunosuppression in Lymphoma
Part of Human Gene Therapy, p. 498-505, 2015
Elevated Post-Transplant Cancer Incidence And Reduced Survival In Patients With Pretransplant Tumors
Part of Transplant International, p. 183-184, 2015
Part of Transplantation, p. 1036-1042, 2015