Ulf Gyllensten – New molecular methods for improved diagnostics and screening for gynecological cancer
The research in our group focuses on developing new methods for diagnostics and screening of the three main forms of gynecological cancer; cervical cancer (or cervical cancer), ovarian cancer and endometrial cancer (or uterine cancer).
Globally, 1.3 million women develop one of these forms of cancer annually, and about fifty per cent of them die from their disease. To reduce the number of women affected, better tests for early diagnosis and screening are needed.
Identifying new biomarkers
We are working with clinicians and clinical researchers to identify new molecular biomarkers that can be used to improve diagnostics for women seeking care, and to enable the development of a screening program for all these cancers. Especially for ovarian cancer, early detection through screening is the only possibility to reduce mortality. With regard to cervical cancer, we are also working to improve the existing screening program and to develop screening models suitable for developing countries.
To accomplish this, we work with multi-omics methods, i.e. large-scale analyses of both DNA, RNA and protein, to search for biomarkers that can be used for early detection or provide knowledge about the cancer’s stage of development.
Group members
Publications
Part of iScience, 2024
Part of The Plant Journal, p. 944-955, 2024
- DOI for Whole-genome resequencing facilitates the development of a 50K single nucleotide polymorphism genotyping array for Scots pine (Pinus sylvestris L.) and its transferability to other pine species
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Complete Mitochondrial DNA Genome Variation in the Swedish Population
Part of Genes, p. 1989-1989, 2023
Part of Forensic Science International, 2023
- DOI for Forensic prediction of sex, age, height, body mass index, hip-to-waist ratio, smoking status and lipid lowering drugs using epigenetic markers and plasma proteins
- Download full text (pdf) of Forensic prediction of sex, age, height, body mass index, hip-to-waist ratio, smoking status and lipid lowering drugs using epigenetic markers and plasma proteins
Genetic insights into resting heart rate and its role in cardiovascular disease
Part of Nature Communications, 2023
Part of Nature Immunology, p. 1540-1551, 2023
Next generation pan-cancer blood proteome profiling using proximity extension assay
Part of Nature Communications, 2023
Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas
Part of Neuro-Oncology, p. 97-107, 2023
Part of Molecular Psychiatry, p. 475-482, 2023
Part of Nature Communications, 2022
Part of Nature Communications, 2022
Part of Communications Medicine, 2022
- DOI for Data-driven analysis of a validated risk score for ovarian cancer identifies clinically distinct patterns during follow-up and treatment
- Download full text (pdf) of Data-driven analysis of a validated risk score for ovarian cancer identifies clinically distinct patterns during follow-up and treatment
Genetic Landscape of the ACE2 Coronavirus Receptor
Part of Circulation, p. 1398-1411, 2022
Part of Nature Genetics, p. 1332-1344, 2022
- DOI for Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
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Implementing precision medicine in a regionally organized healthcare system in Sweden.
Part of Nature Medicine, p. 1980-1982, 2022
Part of Infectious Agents and Cancer, 2022
Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.
Part of Cancers, 2022
Part of International Journal of Molecular Sciences, 2022
- DOI for The Value of Whole-Genome Sequencing for Mitochondrial DNA Population Studies: Strategies and Criteria for Extracting High-Quality Mitogenome Haplotypes
- Download full text (pdf) of The Value of Whole-Genome Sequencing for Mitochondrial DNA Population Studies: Strategies and Criteria for Extracting High-Quality Mitogenome Haplotypes
Brush Samples of Oral Lesions to FTA Elute Card for High-risk Human Papilloma Virus Diagnosis
Part of Anticancer Research, p. 269-277, 2021
Part of International Journal of Cancer, p. 3051-3059, 2021
- DOI for Comparison of vaginal self-sampling and cervical sampling by medical professionals for the detection of HPV and CIN2+: a randomized study
- Download full text (pdf) of Comparison of vaginal self-sampling and cervical sampling by medical professionals for the detection of HPV and CIN2+: a randomized study
Part of Cancers, 2021
Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
Part of Cellular and Molecular Life Sciences (CMLS), p. 4019-4033, 2021
Part of medRxiv : the preprint server for health sciences, p. 1-28, 2021
Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer
Part of Cancer Research, p. 1148-1152, 2021
Part of European Journal of Human Genetics, p. 1510-1519, 2021
Part of PLOS ONE, 2020
Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity
Part of Genome Biology, 2020
Part of BMC Cancer, 2020
Part of Genes, 2020
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Part of Nature Metabolism, p. 1135-1148, 2020
Part of International Journal of Infectious Diseases, p. 176-182, 2020
- DOI for Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa
- Download full text (pdf) of Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa
Part of Nature Communications, 2020
Preoperative Fasting and General Anaesthesia Alter the Plasma Proteome
Part of Cancers, 2020
SweHLA: the high confidence HLA typing bio-resource drawn from 1000 Swedish genomes
Part of European Journal of Human Genetics, p. 627-635, 2020
Part of Virology Journal, 2020
The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly
Part of Nature Communications, 2020
Associations of autozygosity with a broad range of human phenotypes
Part of Nature Communications, 2019
Part of Virology Journal, 2019
- DOI for Clinical validation of the HPVIR high-risk HPV test on cervical samples according to the international guidelines for human papillomavirus DNA test requirements for cervical cancer screening
- Download full text (pdf) of Clinical validation of the HPVIR high-risk HPV test on cervical samples according to the international guidelines for human papillomavirus DNA test requirements for cervical cancer screening
Part of European journal of obstetrics & gynecology and reproductive biology: X, 2019
Epigenome-wide association study of lung function level and its change
Part of European Respiratory Journal, 2019
Part of Nature Genetics, p. 494-505, 2019
Part of Communications Biology, 2019
Part of Virology Journal, 2019
Part of Molecular & Cellular Proteomics, p. 735-743, 2019
Part of Carcinogenesis, p. 269-278, 2019
Part of Nature Genetics, p. 481-493, 2019
Part of International Journal of Cancer, p. 89-97, 2019
Part of Frontiers in Genetics, 2018
Part of Clinical Proteomics, 2018
Cervical dysplasia in elderly women performing repeated self-sampling for HPV testing
Part of PLOS ONE, 2018
Part of Genes, 2018
- DOI for De Novo Assembly of Two Swedish Genomes Reveals Missing Segments from the Human GRCh38 Reference and Improves Variant Calling of Population-Scale Sequencing Data
- Download full text (pdf) of De Novo Assembly of Two Swedish Genomes Reveals Missing Segments from the Human GRCh38 Reference and Improves Variant Calling of Population-Scale Sequencing Data
Part of Human Mutation, p. 1262-1272, 2018
Part of Nature Genetics, p. 1412-1425, 2018
Genetic variants influencing phenotypic variance heterogeneity
Part of Human Molecular Genetics, p. 799-810, 2018
Meta-analysis of exome array data identifies six novel genetic loci for lung function.
Part of Wellcome open research, 2018
Part of British Journal of Cancer, p. 896-904, 2018
- DOI for Randomised study shows that repeated self-sampling and HPV test has more than two-fold higher detection rate of women with CIN2+ histology than Pap smear cytology
- Download full text (pdf) of Randomised study shows that repeated self-sampling and HPV test has more than two-fold higher detection rate of women with CIN2+ histology than Pap smear cytology
Part of Scientific Reports, 2018
- DOI for Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases
- Download full text (pdf) of Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases
Part of Scientific Reports, 2018
Epigenome-wide DNA methylation study of IgE concentration in relation to self-reported allergies
Part of Epigenomics, p. 407-418, 2017
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function
Part of International Journal of Epidemiology, p. 894-904, 2017
Part of Nature Genetics, p. 416-425, 2017
Part of Nature Genetics, p. 403-415, 2017
Genome-wide physical activity interactions in adiposity: A meta-analysis of 200,452 adults.
Part of PLOS Genetics, 2017
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
Part of PLOS Genetics, 2017
Part of Hypertension, 2017
PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c
Part of Nucleic Acids Research, p. 2408-2422, 2017
Part of European Journal of Human Genetics, p. 1253-1260, 2017
Part of PLOS Genetics, 2017
A multiple-phenotype imputation method for genetic studies
Part of Nature Genetics, p. 466-472, 2016
Part of EBioMedicine, p. 309-314, 2016
Part of Human Molecular Genetics, p. 4739-4748, 2016
Part of Nature Communications, 2016
Part of Human Molecular Genetics, p. 817-827, 2016
Identification of novel genetic causes of Rett syndrome-like phenotypes
Part of Journal of Medical Genetics, p. 190-199, 2016
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 14372-14377, 2016
Part of Oncotarget, p. 42216-42224, 2016
Part of Nature Genetics, p. 1171-1184, 2016
Part of Human Molecular Genetics, p. 2681-2688, 2015
Part of Carcinogenesis, p. 992-998, 2015
Daily self-sampling for high-risk human papillomavirus (HR-HPV) testing.
Part of Journal of Clinical Virology, p. 1-7, 2015
Part of Genetical Research, 2015
Directional dominance on stature and cognition in diverse human populations
Part of Nature, p. 459-462, 2015
Part of Biomarkers, p. 355-364, 2015
Genetic studies of body mass index yield new insights for obesity biology
Part of Nature, p. 197-206, 2015
Homozygous loss-of-function variants in European cosmopolitan and isolate populations
Part of Human Molecular Genetics, p. 5464-5475, 2015
Identification of novel genetic causes of Rett syndrome-like phenotypes by whole exome sequencing
Part of International Journal of Developmental Neuroscience, p. 99-99, 2015
Lessons and implications from association studies and post-GWAS analyses of cervical cancer
Part of Trends in Genetics, p. 41-54, 2015
Part of Nature Communications, 2015
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
Part of PLOS ONE, 2015
Protein profiling reveals consequences of lifestyle choices on predicted biological aging
Part of Scientific Reports, 2015
Protein profiling reveals consequences of lifestyle choices on predicted biological aging
Part of Scientific Reports, 2015
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Part of Nature Communications, 2015
Part of PLOS Genetics, 2015
Part of Cancer Medicine, p. 445-452, 2014
- DOI for A cis-eQTL of HLA-DRB1 and a frameshift mutation of MICA contribute to the pattern of association of HLA alleles with cervical cancer
- Download full text (pdf) of A cis-eQTL of HLA-DRB1 and a frameshift mutation of MICA contribute to the pattern of association of HLA alleles with cervical cancer
Part of Cancer Medicine, p. 190-198, 2014
Part of Database, 2014
Part of Scientific Reports, p. 4398, 2014
Part of Nature Genetics, p. 1173-1186, 2014
Genome-wide association analysis identifies six new loci associated with forced vital capacity
Part of Nature Genetics, p. 669-677, 2014
HLA Typing By SMRT Sequencing: Advantages Of Full Length HLA Genotyping In Clinical Routine
Part of Tissue Antigens, p. 113-113, 2014