Preclinical Cancer Treatment (PCT) Centre
The Preclinical Cancer Treatment (PCT) Centre is supported by Uppsala University - Disciplinary Domain of Medicine and Pharmacy, U-CAN and SciLifeLab. The PCT Centre provide services for preclinical and clinical researchers that are evaluating novel drugs in combination with standard treatments in vivo or that conduct controlled studies for refining current cancer therapies in vivo.
The facility uses medical systems similar to those used in the clinical setting for treating patients, including high accuracy image guided irradiation, Computed Tomography (CT) imaging and standard chemotherapy treatment. The efficacy of irradiation treatment or of e.g. novel targeted therapies can be further evaluated using bioluminescent imaging.
The PCT Centre is equipped with both an advanced cone-beam-CT guided X-ray irradiator and a bioluminescence imaging system.
The Small Animal Radiation Research Platform (SARRP) at the center
The rotating gantry and motorized stage allows for beam delivery from any angle
The SARRP performs image guided irradiation
Service at PCT
The facility located in Uppsala provides researchers in academia, industry, and clinical departments with the following services:
- Help with irradiation treatment planning
- Multi-fractionated image-guided radiotherapy
- Chemotherapy
- CT imaging
- 3D bioluminescence imaging
- Tumor model development
- Drug administration
- Tumor resection and sampling
- Animal ethical permit consultation
- In vivo ADME (with SciLifeLab/DDD)
We work in synergy with other SciLifeLab platforms like the National Genomics Infrastructure (NGI), Drug Discovery Development (DDD), the Preclinical PET Platform (PPP), and other imaging facilities at the University.
Using the PCT facility
The PCT Centre is open for academic researchers from within and outside of Uppsala University as well as researchers from industry.
Project proposals will be assessed and prioritized by the facility staff. For projects that are considered feasible and of good scientific quality, the facility staff together with the researcher will decide how to proceed and how the project will be executed. Project details and timelines will be outlined in a written agreement between the PCT Center and the researcher.
Project requests can be made at the facility's iLab site, see also separate instructions.
Contact tobias.bergstrom@igp.uu.se for further instructions.
Pricing
Work at the facility is charged per hour according to the following price list:
- UU Internal 1329 SEK/hr
- Governmental 1660 SEK/hr
- Non-Governmental 2049 SEK/hr