Entry requirements

120 credits in Science including 60 credits Chemistry, or equivalent.

Learning outcomes

The successful participant of this course will have the ability to:

• Apply retrosynthetic analysis to organic compounds with low molecular weight.
• Describe and plan DOS (diversity-oriented synthesis)
• Devise strategies in combinatorial and parallel synthesis.
• Plan chemical synthesis of peptide and non-peptide libraries.
• Present, discuss, plan and execute construction and evaluation of a low-molecular-weight compound library.

Content

The theoretical part of the course begins with retrosynthetic analysis and its application in organic synthesis.

During the experimental part of the course, the student will execute an efficient strategy for the synthesis of a short library of molecules with a rich diversity in respect to skeleton and stereochemistry.

"DOS" (Diversity Oriented Synthesis) for an efficient synthesis of substances that well represents the chemical space.

Fundaments in chemical genetics: How to use small molecules to understand complex biological processes in a systematic manner.

High-throughput synthesis methods: Solid-supported synthesis, solution-phase multicomponent reactions.

Analysis and monitoring of chemical libraries.

Instruction

The teaching will be conducted by lectures, practical work in the laboratory, theoretical exercises, and by projects. Practice in oral and written assignments will be given. In the initial part of the course the lectures will be held by lecturers and this will be followed by lectures held by students. Some lectures might be held by invited lecturers from the pharmaceutical industry. A major part of the course will be devoted to project assignments, where the students will work individually and together in groups. During the progress of the course, the students will plan, execute, and present their projects. The projects and the exercises are mandatory.

Assessment

A written exam will be given in the end of the course. To pass the course, both the theoretical and practical part of the course has to be passed. The written exam equals 10 HE credits, the mandatory exercises, and reports equals 5 HE credits. The final grade is based on both the written exam and the mandatory exercises.