General provisions

Correspond earlier the 3FK004 of course General Pharmaceutical Chemistry. 1.5 credits (hp) correspond to 1 credit point (p) according to earlier study regulation.

Entry requirements

General entry requirements and Biology 2, Physics 1a/1b1+1b2, Chemistry 2, Mathematics 4 or Biology B, Physics A, Chemistry B, Mathematics D

Learning outcomes

On completion of the course, the student should be able to:

- explain the basic theories and laws that govern the structure of matter and apply them within chemistry, mainly considering the need within the pharmaceutical field.

- account for elementary quantum mechanics as a basis for the structure and properties of the atom.

- explain various types of chemical binding including intermolecular interaction and the chemical binding connection to physico-chemical properties.

- predict the hybridisation of atoms and the geometry of molecules

- define the reaction order and calculate the reaction rate for various types of chemical reactions.

- apply basic thermodynamic principles and concept.

- calculate the steady-state concentration the solubility and pH in water solutions.

- account for chemical equilibria importance for quantitative and qualitative analyses.

- account for chemical equilibria importance for the fate of drug in the body.

Content

In the section chemical binding, elementary quantum mechanics as a basis for atomic structure and covalent binding are treated. Further, the structure of the atom and properties are described, intra - and intermolecular interaction and the connection to physico-chemical properties and molecular geometries of the chemical binding. Zero, first and the kinetics of the other order be gone through. Within thermodynamics, the energy conservation theorem (the 1st main clause), the concepts of internal energy, enthalpy, thermal capacity, entropy (the 2nd main clause) and Gibb's free energy, spontaneous processes and the connection are treated to the equilibrium constant and its temperature dependence. Further, chemical equilibria are treated (acid/base, solubility - and distribution equilibria), connected equilibria and the equilibria importance for the fate of drug in the body (dissolution, absorption and transport). Furthermore, using chemical equilibria for quantitative and qualitative analyses is treated (titrimetric analysis and extraction).

Instruction

The teaching is given as lectures, group work, seminars, demonstrations and laboratory sessions. The results of laboratory exercises are presented orally and in writing.

Compulsory parts of the course:

Start of the course and all parts in connection with laboratory sessions.

Assessment

Examination is organised during the course and at the end of the course. For approved examination, it is required that the student has participated in all compulsory parts of the course. Possibility to supplement failed laboratory course can be given at the earliest at next course and only in case of a vacancy. For passed in the course, passed laboratory course (examination code) and passed examination (examination code) are required. Students who have failed the first examination are allowed five re-examinations.