Chemical Molecular Design
Syllabus, Master's level, 1KB453
- Education cycle
- Second cycle
- Main field(s) of study and in-depth level
- Chemistry A1N
- Grading system
- Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
- Finalised by
- The Faculty Board of Science and Technology, 23 April 2014
- Responsible department
- Department of Chemistry - BMC
120 credits in Science including 60 credits Chemistry, or equivalent.
After successful completion of the course, the participant should have the ability to:
- describe and discuss and perform design of compounds for molecular recognition of small and biomacromolecular targets
- describe and discuss common properties and principles of organometallic and organocatalysts, enzymes and engineered enzymes
- plan design and chemical modification of proteins
- evaluate cost - benefit relationships in the design and synthesis of organic molecules
- plan the preparation of simple artificial enzymes
Design of small organic molecules for the recognition of bio-macromolecules, their surface or active centre. Recognition of domains and complexes.
Studies and comparison of different types of molecular recognition; small vs small (exemplified by organometallic and organocatalysts), small vs large (exemplified by natural and artificial enzymes), large vs large (exemplified by protein-protein interactions).
Design of molecules that inhibit the interaction between bio-macromolecules: inhibition of protein-protein interactions, inhibition of interactions of nucleic acids. Design and molecular recognition in drug discovery. Design of catalysts: organometallic catalysis and organocatalysis. Reengineering of enzymes, design of new enzymes.
The student shall in group projects identify suitable structures and plan their synthesis and evaluation.
Lectures, seminars , literature searches, and theoretical projects. Training in oral and written reports. Participation in seminars and projects is mandatory.
Written exam at the end of the course, 7 credits. The seminar and project corresponds to 3 credits. The final grade is a weighted combination of the individual grades.