Chemical Molecular Design

10 credits

Syllabus, Master's level, 1KB453

A revised version of the syllabus is available.
Education cycle
Second cycle
Main field(s) of study and in-depth level
Chemistry A1N
Grading system
Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
Finalised by
The Faculty Board of Science and Technology, 23 April 2014
Responsible department
Department of Chemistry - BMC

Entry requirements

120 credits in Science including 60 credits Chemistry, or equivalent.

Learning outcomes

After successful completion of the course, the participant should have the ability to:

  • describe and discuss and perform design of compounds for molecular recognition of small and biomacromolecular targets
  • describe and discuss common properties and principles of organometallic and organocatalysts, enzymes and engineered enzymes
  • plan design and chemical modification of proteins
  • evaluate cost - benefit relationships in the design and synthesis of organic molecules
  • plan the preparation of simple artificial enzymes


Design of small organic molecules for the recognition of bio-macromolecules, their surface or active centre. Recognition of domains and complexes.

Studies and comparison of different types of molecular recognition; small vs small (exemplified by organometallic and organocatalysts), small vs large (exemplified by natural and artificial enzymes), large vs large (exemplified by protein-protein interactions).

Design of molecules that inhibit the interaction between bio-macromolecules: inhibition of protein-protein interactions, inhibition of interactions of nucleic acids. Design and molecular recognition in drug discovery. Design of catalysts: organometallic catalysis and organocatalysis. Reengineering of enzymes, design of new enzymes.

The student shall in group projects identify suitable structures and plan their synthesis and evaluation.


Lectures, seminars , literature searches, and theoretical projects. Training in oral and written reports. Participation in seminars and projects is mandatory.


Written exam at the end of the course, 7 credits. The seminar and project corresponds to 3 credits. The final grade is a weighted combination of the individual grades.