Population Genetic Analysis

5 credits

Syllabus, Master's level, 1MB514

A revised version of the syllabus is available.
Code
1MB514
Education cycle
Second cycle
Main field(s) of study and in-depth level
Bioinformatics A1F, Biology A1F, Technology A1F
Grading system
Pass with distinction, Pass with credit, Pass, Fail
Finalised by
The Faculty Board of Science and Technology, 15 February 2018
Responsible department
Biology Education Centre

Entry requirements

120 credits and at least one of the courses Molecular Evolution, Evolutionary Processes, or Genetic and Molecular Plant Science

Learning outcomes

The aim of the course is to provide the student with knowledge in theory and analytical methods in population genetics. After having passed the course the student should be able to

  • Solve biological problems with the help of population genetics principles
  • Explain the principles of population genetics
  • Identify relevant question formulations in population genetics and propose strategies to solve the problems
  • Use previously acquired knowledge (mathematics, statistics and programming) to solve genetic problems

Content

The course begins with an introduction to genetic heritance and mendelian genetics, followed by two main parts

  • The principles of population genetics: allele frequencies, spectrum of allele frequencies, linkage disequilibrium, genetic diversity and measures of diversity, Wright-Fisher model, coalescense theory, inbreeding, population structure and selection.
  • Analysis of population genetics: coalescense theory and simulations, estimation of parameters (mutational and recombination rates) and neutrality tests. Examples of complex models.

Instruction

The teaching is done in the form of lectures, seminars and exercises (mathematical problems, analytical problems and computer exercises.

Assessment

Theory test 4 credits; seminars and exercises 1 credit. For passing the course, the student should be present in at least 80% of the seminars. All the analytical problems should be solved and the solutions presented in an written form should be given a passing grade by the teacher. The theory part is examined by a written examination.

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