Entry requirements

Participation in Basic Chemistry, 10 credits.

Learning outcomes

On completion of the course, the student should be able to:

• apply rules for the description of structure and stereochemistry of organic compounds
• relate chemical structure to properties such as melting point, boiling point, viscosity, chirality, acid strength, interaction with light (e. g., colour) and binding ability (hydrogen bond formation, lipophilicity, hydrophilicity)
• explain the terms nucleophile and electrophile give examples for the most common reactions of functional groups, apply chemical reaction theory including substitution, addition, and elimination reactions, and interpret reactivity of organic compounds using the Lewis acid-base concept
• carry out simpler risk and security assessments, plan and carry out laboratory work in a correct and safe manner, describe and use chromatographic methods for the determination of oganic compounds and document the results
• describe how some course concepts are applied within the biomolecular and pharmaceutical sciences and give examples of how chemical properties and reactivity can influence environmental and economical decisions
• discuss similarities and differences between transformations of biomolecules in vivo and in vitro (e.g. industrial synthesis)

Content

Various models for the description and understanding of organic molecular structure (functional groups, isomerism, chirality and conformers). Consequences of binding and structure for molecular properties. Inter- and intramolecular interactions. Reaction types: Substitution, elimination, addition, radical reactions, reaction kinetics, catalysis. Organic chemistry of biologically relevant compound classes: Carbohydrates, lipids, amino acids and peptides, and nucleic acids, and the importance of stereochemistry in these compounds. Reaction mechanisms to build up and break down carbon compounds. Examples of catalytic reactions: Acid -base catalysis, enzymatic catalysis, metal catalysis. Organic chemical reactions in water. Comparison between synthesis in biological systems and industrial synthesis. Information on spectroscopic methods in organic chemistry (UV, IR, MS, NMR). Analysis of biomolecules, e g, peptides and nucleic acids by chemical and spectroscopic methods. The fundamentals of chromatographic separation.

Laboratory exercises: Organic syntheses exemplifying theory, synthtetic techniques, purification and separation as well as structural characterisation using spectroscopic methods.

Instruction

Lectures, problem solving sessions and laboratory work. Laboratory work and related oral presentations and written reports are mandatory.

Assessment

Written examination, 5 credits and laboratory work, 5 credits. The final grade is the weighted grade of both theoretical and experimentel work.

If there are special reasons for doing so, an examiner may make an exception from the method of assessment indicated and allow a student to be assessed by another method. An example of special reasons might be a certificate regarding special pedagogical support from the disability coordinator of the university.

Other directives

The course can not be included in higher education qualification together with 1KB400 Organic Chemistry and 1KB406 Bioorganic Chemistry.