Aims

After successful completion of the course, the participant should have:

- the ability to investigate and determine the structure of typical organic chemical compounds (molecular weight up to ca. 500 Da) using suitable nuclear magnetic resonance experiments.

- knowledge of the theory for the most commonly used experiments, the ability to peroform these experiments, and to interpret and docoument their results.

Content

Funamentals of the NMR phenomenon, relationship between NMR spectra and molecular structure. Recording of routine spectra (1H and 13C), essentials of data processing (e.g., weighting functions). 1D NMR techniques: Decoupling, DEPT, relaxation measurement, magnetisation transfer, NOE difference spectra. 2D NMR techniques: Homo- and heteronuclear correlation (COSY, TOCSY, HSQC, HMBC), measurement of the nuclear Overhauser effect (NOESY, ROESY). Emphasis is on learning the practical use of NMR equipment.

Instruction

Lectures, seminars, group work and laboratory work. Exercises in oral and written presentation. Seminars, laboratory work, and related oral presentation are mandatory.

Assessment

Written examination is arranged during the course and at the end of the course. The laboratory work must also be passed. The mandatory exercies are valued as 4 p.