Danielsons grupp

Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors

FitzGerald, Edward; Vagrys, Darius; Opassi, Giulia; Klein, Hanna F. et al.

Ingår i SLAS Discovery, s. 40-51, 2024

• DOI för Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors
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Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein

Fekry, Mostafa; Stenberg, Gun; Dobritzsch, Doreen; Danielson, U. Helena

Ingår i Protein Expression and Purification, 2024

• DOI för Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein
• Ladda ner fulltext (pdf) av Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein

Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening

FitzGerald, Edward A.; Cederfelt, Daniela; Lund, Bjarte Aarmo; Myers, Nadine et al.

Ingår i RSC Medicinal Chemistry, s. 1982-1990, 2024

• DOI för Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening

The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase

Fekry, Mostafa; Dave, Khyati K.; Badgujar, Dilip; Hamnevik, Emil et al.

Ingår i Biomolecules, 2023

• DOI för The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase
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The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces

Cederfelt, Daniela; Badgujar, Dilip; Au Musse, Ayan; Lohkamp, Bernhard et al.

Ingår i Biomolecules, 2023

• DOI för The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces
• Ladda ner fulltext (pdf) av The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces

Amino acid substitutions in human growth hormone affect secondary structure and receptor binding

Rajkovic, Andrei; Kanchugal, Sandesh; Abdurakhmanov, Eldar; Howard, Rebecca et al.

Ingår i PLOS ONE, 2023

• DOI för Amino acid substitutions in human growth hormone affect secondary structure and receptor binding
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Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

Parenti, Marco Daniele; Naldi, Marina; Manoni, Elisabetta; Fabini, Edoardo et al.

Ingår i European Journal of Medicinal Chemistry, 2022

• DOI för Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents

Al-Amin, Rasel Abdullah; Muthelo, Phathutshedzo M.; Abdurakhmanov, Eldar; Vincke, Cecile et al.

Ingår i Analytical Chemistry, s. 10054-10061, 2022

• DOI för Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents
• Ladda ner fulltext (pdf) av Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Ingår i Journal of the American Chemical Society, s. 2905-2920, 2022

• DOI för Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
• Ladda ner fulltext (pdf) av Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

Ingår i Nucleic Acids Research, 2022

• DOI för Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
• Ladda ner fulltext (pdf) av Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

FitzGerald, Edward A.; Butko, Margaret T.; Boronat, Pierre; Cederfelt, Daniela et al.

Ingår i RSC Advances, s. 7527-7537, 2021

• DOI för Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
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Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Talibov, Vladimir O; Fabini, Edoardo; FitzGerald, Edward; Tedesco, Daniele et al.

Ingår i ChemBioChem, s. 1597-1608, 2021

• DOI för Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
• Ladda ner fulltext (pdf) av Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Öhman Fuchs, Peder; Calitz, Carlemi; Pavlovic, Natasa; Binet, Francois et al.

Ingår i Cellular Signalling, 2020

• DOI för Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
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A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells

Encarnacao, Joao Crispim; Napolitano, Valeria; Opassi, Giulia; Danielson, U. Helena et al.

Ingår i FEBS Letters, s. 2406-2420, 2020

• DOI för A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells
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Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery

Opassi, Giulia; Nordström, Helena; Lundin, Arne; Napolitano, Valeria et al.

Ingår i Protein Science, s. 991-1003, 2020

• DOI för Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery
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Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Yang, Jie; Talibov, Vladimir O; Peintner, Stefan; Rhee, Claire et al.

Ingår i ACS Omega, s. 3979-3995, 2020

• DOI för Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
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Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses

Xu, Xingxing; Makaraviciute, Asta; Abdurakhmanov, Eldar; Werneling, Fredrik et al.

Ingår i ACS Sensors, s. 217-224, 2020

• DOI för Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses

Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Fabini, Edoardo; Talibov, Vladimir O; Mihalic, Filip; Naldi, Marina et al.

Ingår i Biochemistry, s. 3634-3645, 2019

• DOI för Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Structural Changes of Mercaptohexanol Self-assembled Monolayers on Gold and their Influence on Impedimetric Aptamer Sensors

Xu, Xingxing; Makaraviciute, Asta; Kumar, Shalen; Wen, Chenyu et al.

Ingår i Analytical Chemistry, s. 14697-14704, 2019

• DOI för Structural Changes of Mercaptohexanol Self-assembled Monolayers on Gold and their Influence on Impedimetric Aptamer Sensors

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Ingår i European Journal of Medicinal Chemistry, s. 453-464, 2018

• DOI för Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design

Linkuviene, Vaida; Talibov, Vladimir O; Danielson, U. Helena; Matulis, Daumantas

Ingår i Journal of Medicinal Chemistry, s. 2292-2302, 2018

• DOI för Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Pandya, Nikhil J; Seeger, Christian; Babai, Norbert; Gonzalez-Lozano, Miguel A et al.

Ingår i Cell Reports, s. 1218-1230, 2018

• DOI för Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors
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Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Saupe, Falk; Reichel, Matthias; Huijbers, Elisabeth J. M.; Femel, Julia et al.

Ingår i The FASEB Journal, s. 1204-1214, 2017

• DOI för Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Monitoring drug-serum protein interactions for early ADME prediction through Surface Plasmon Resonance technology

Fabini, Edoardo; Danielson, U. Helena

Ingår i Journal of Pharmaceutical and Biomedical Analysis, s. 188-194, 2017

• DOI för Monitoring drug-serum protein interactions for early ADME prediction through Surface Plasmon Resonance technology

Insights from engineering the Affibody-Fc interaction with a computational-experimental method

Nosrati, Masoumeh; Solbak, Sara; Nordesjö, Olle; Nissbeck, Mikael et al.

Ingår i Protein Engineering Design & Selection, s. 593-601, 2017

• DOI för Insights from engineering the Affibody-Fc interaction with a computational-experimental method

Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca²⁺/calmodulin-dependent kinase II

Seeger, Christian; Talibov, Vladimir O; Danielson, U. Helena

Ingår i Journal of Molecular Recognition, s. 1-11, 2017

• DOI för Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca²⁺/calmodulin-dependent kinase II
• Ladda ner fulltext (pdf) av Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca²⁺/calmodulin-dependent kinase II

Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Linkuviene, V.; Talibov, Vladimir O.; Danielson, U. Helena; Matulis, D.

Ingår i European Biophysics Journal, 2017

• DOI för Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Linkuviene, V.; Talibov, Vladimir O; Danielson, U. Helena; Matulis, D.

Ingår i European Biophysics Journal, 2017

• DOI för Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition

Solbak, Sara M.Ø.; Abdurakhmanov, Eldar; Vedeler, Anni; Danielson, U. Helena

Ingår i Virology Journal, 2017

• DOI för Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition
• Ladda ner fulltext (pdf) av Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition

Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

Abdurakhmanov, Eldar; Solbak, Sara Oie; Danielson, U. Helena

Ingår i Viruses, 2017

• DOI för Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase
• Ladda ner fulltext (pdf) av Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

Let There Be Light!

Raykova, Doroteya; Koos, Bjoern; Asplund, Anna; Gelleri, Marton et al.

Ingår i Proteomes, 2016

• DOI för Let There Be Light!
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Biophysics in drug discovery: impact, challenges and opportunities

Renaud, Jean-Paul; Chung, Chun-wa; Danielson, U. Helena; Egner, Ursula et al.

Ingår i Nature reviews. Drug discovery, s. 679-698, 2016

• DOI för Biophysics in drug discovery: impact, challenges and opportunities

Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

Talibov, Vladimir O; Linkuvienė, Vaida; Matulis, Daumantas; Danielson, Helena U.

Ingår i Journal of Medicinal Chemistry, s. 2083-2093, 2016

• DOI för Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 2603-2620, 2016

• DOI för Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Identification and Characterization of an Irreversible Inhibitor of CDK2

Anscombe, Elizabeth; Meschini, Elisa; Mora-Vidal, Regina; Martin, Mathew P. et al.

Ingår i Chemistry and Biology, s. 1159-1164, 2015

• DOI för Identification and Characterization of an Irreversible Inhibitor of CDK2
• Ladda ner fulltext (pdf) av Identification and Characterization of an Irreversible Inhibitor of CDK2

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

Spurny, Radovan; Debaveye, Sarah; Farinha, Ana; Veys, Ken et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2015

• DOI för Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

Danielson, U. Helena

Ingår i Multifaceted Roles Of Crystallography In Modern Drug Discovery, s. 223-240, 2015

• DOI för Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

Proximity-dependent initiation of hybridization chain reaction

Koos, Björn; Cane, Gaëlle; Grannas, Karin; Löf, Liza et al.

Ingår i Nature Communications, 2015

• DOI för Proximity-dependent initiation of hybridization chain reaction
• Ladda ner fulltext (pdf) av Proximity-dependent initiation of hybridization chain reaction

Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria

Danielson, U Helena; Huang, H H; Seeger, Christian; Lindblad, Peter

Ingår i BMC Research Notes, s. 459, 2015

Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria

Huang, Hsin-Ho; Seeger, Christian; Danielson, U. Helena; Lindblad, Peter

Ingår i BMC Research Notes, 2015

• DOI för Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria
• Ladda ner fulltext (pdf) av Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria

Identification of weak points of hepatitis C virus NS3 protease inhibitors using surface plasmon resonance biosensor-based interaction kinetic analysis and genetic variants

Svahn Gustafsson, Sofia; Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Mohammed Ikram et al.

Ingår i Journal of Medicinal Chemistry, s. 1802-1811, 2014

Identification and characterization of an irreversible inhibitor of CDK2

Martin, M.; Anscombe, E.; Meschini, E.; Staunton, D. et al.

Ingår i European Journal of Cancer, s. 106-106, 2014

• DOI för Identification and characterization of an irreversible inhibitor of CDK2

The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

Manfroni, Giuseppe; Cannalire, Rolando; Barreca, Maria Letizia; Kaushik-Basu, Neerja et al.

Ingår i Journal of Medicinal Chemistry, s. 1952-1963, 2014

• DOI för The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Ingår i Journal of Medicinal Chemistry, s. 1790-1801, 2014

• DOI för Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Identification of Weak Points of Hepatitis C Virus NS3 Protease Inhibitors Using Surface Plasmon Resonance Biosensor-Based Interaction Kinetic Analysis and Genetic Variants

Svahn Gustafsson, Sofia; Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Muhammad Ikram et al.

Ingår i Journal of Medicinal Chemistry, s. 1802-1811, 2014

• DOI för Identification of Weak Points of Hepatitis C Virus NS3 Protease Inhibitors Using Surface Plasmon Resonance Biosensor-Based Interaction Kinetic Analysis and Genetic Variants

Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors

Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Muhammad Ikram; Svahn Gustafsson, Sofia et al.

Ingår i Journal of enzyme inhibition and medicinal chemistry (Print), s. 868-876, 2014

• DOI för Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 6595-6615, 2014

• DOI för Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Ingår i ACS Medicinal Chemistry Letters, s. 249-254, 2014

• DOI för Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

Barreca, Maria Letizia; Manfroni, Giuseppe; Leyssen, Pieter; Winquist, Johan et al.

Ingår i Journal of Medicinal Chemistry, s. 2270-2282, 2013

• DOI för Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

Structural basis of ligand recognition in 5-HT3 receptors

Kesters, D.; Thompson, A. J.; Brams, M.; Van Elk, R. et al.

Ingår i EMBO Reports, s. 49-56, 2013

• DOI för Structural basis of ligand recognition in 5-HT3 receptors