Molecular Tools for Proteome Analysis and Diagnostics 2019/2020 (7.5 credits)

Course Code: 3MG026

Spring 2020, 100 %, Campus

Start date: 23 March 2020

End date: 3 May 2020

Location: Uppsala

Entry Requirements: 180 credits in biology, bio-/medicine, biotechnology, pharmaceutical biosciences, medical science or equivalent international education giving relevant knowledge in cell biology, genetics biochemistry and molecular biology. Proficiency in English.

About the course:

The course will provide an insight into the applications, strategies and implications of molecular analysis methods in research and medicine. Current opinions and research findings, as well as development of novel methods and technologies, will be conveyed and discussed throughout the course. Different methods for protein analysis, including a variety of affinity-based protein detection methods, will be covered. Molecular tools and technologies such as e.g. affibodies, their use in cancer therapy and LigandTracer, showing protein-cell interactions in real-time, will be discussed. Molecular diagnostic methods will also be practically illustrated using Proximity ligation assays (PLA) for detection of proteins in solution as well as detection of complex formation in situ. Methods and tools used in the Human Proteome Project, e.g. high-throughout in situ detection of protein expression in different tissues and cancers will be treated. The development of novel molecular diagnostic methods for different diseases, including nanotechnology based diagnostics, and their application in medical clinics will be discussed.

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