Chemical Molecular Design
Syllabus, Master's level, 1KB453
- Code
- 1KB453
- Education cycle
- Second cycle
- Main field(s) of study and in-depth level
- Chemistry A1N
- Grading system
- Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
- Finalised by
- The Faculty Board of Science and Technology, 18 October 2021
- Responsible department
- Department of Chemistry - BMC
Entry requirements
120 credits with 60 credits in chemistry of which 10 credits in organic chemistry. 5 credits in biochemistry is recommended. Proficiency in English equivalent to the Swedish upper secondary course English 6.
Learning outcomes
On completion of the course, the student should be able to:
- describe, discuss and perform design of compounds for molecular recognition of small organic molecules as well as large biomolecules, in particular proteins
- describe and discuss the properties and principles that are common to the binding of molecules to each other and to catalysis.
- plan design and chemical modification of proteins
- evaluate cost - benefit relationships in the design and synthesis of organic molecules that bind to different types of molecular targets
- describe how the basic principles of chemical molecular design can be applied to the design of functional biomaterials
Content
Studies and comparison of molecular recognition: small vs small (supramolecular chemistry), small vs large (drug-protein and substrate-enzyme interactions), large vs large (protein-protein interactions).
Application of these principles to the design of molecules that inhibit the interaction between biomacromolecules and between ligands and biomacromolecules, for the development of chemical tools and of drugs.
Modification and design of enzymes and catalytically active polypeptides.
Design of functional surfaces and polymeric biomaterials.
Instruction
Lectures, seminars, literature searches, group work and theoretical projects. Training in oral and written communication . Participation in seminars and projects is mandatory.
Assessment
Written exam at the end of the course, 7 credits. The seminar and project correspond to 3 credits. The final grade is a weighted combination of the individual grades.
If there are special reasons for doing so, an examiner may make an exception from the method of assessment indicated and allow a student to be assessed by another method. An example of special reasons might be a certificate regarding special pedagogical support from the disability coordinator of the university.