General provisions

The course can be taken as a stand-alone course or elective within a program. The course is elective within the Master of Science Program in Pharmacy, the Master's Program in Drug Management and the Master's Programme in Drug Discovery and Development.

Entry requirements

150 credits of which 120 credits in biomedicine, pharmaceutical science, chemistry, natural science and/or engineering. Previous studies should include biochemistry or cell biology. Proficiency in Swedish and English equivalent to the general entry requirements for first-cycle (Bachelor's level) studies.

Learning outcomes

The student should on completion of the course: - be able to account for different mechanisms for enzymatic activation and metabolism of endogenous and foreign compounds particularly mechanisms that concern cholesterol, vitamin D, steroid hormones and drugs - be able to account for various types of methodology that is used in the area of biochemistry/molecular biology - be able to formulate strategies to apply biochemical/molecular biological methodology on research problems - be able to interpret, evaluate and discuss critically about scientific literature in the area of metabolism/bioactivation - be able to analyse the importance of enzymatic transformations in connection with normal and pathological conditions

Content

The course deals with enzymatic activation and metabolism of endogenous and foreign compounds. Special focus is placed on cholesterol, vitamin D, steroid hormones and drugs. The course also gives an insight in research activities and methodology in the area of biochemistry/molecular biology. The course also includes diseases that are due to disturbances in enzymatic functions.

Instruction

The teaching is given as lectures and literature assignments. Emphasis is placed on students' ability to independently acquire and process materials as well as their ability to present material. There is a possibility to, within the frame of the course, specialise in literature assignments according to individual interest. Compulsory parts are, in addition to course introduction, literature seminars with presentations.

Assessment

Examination takes place at the end of the course. To pass the course, passed written examination (4,5 hp) and passed results of compulsory parts are required (3 hp). Possibility to supplement failed compulsory part can be given at the earliest at next course and only in case of a vacancy. Each student has the right to in all six examinations i.e. one examination and five re-examinations.

Other directives

Substituting and corresponding to 3FI203 or 3FI003, Molecular Mechanisms for Enzymatic Activation of endogenous and exogenous compounds.