Publications

With a shared quest for scientific excellence and highly regarded and equally important input from our industrial partners, SweDeliver has accomplished the following qualitative publications:

2024

• Maryam Tofiq. Tableting performance of dry granulated particles: Significance and assessment of compression mechanical properties (Acta Universitatis Upsaliensis, 2024
• Agnes Rodler, Ayan Samanta, Wen-Jun Goh, Jöns Hilborn, Per Hansson. Engineering and characterization of a hydrogel mimicking subcutaneous interstitial space. (European Polymer Journal, Vol. 205, 2024)
• Vicky Barmpatsalou, Marco Tjakra, L. Li, Ilse Dubbelboer, E. Karlsson, Betty Pedersen Lomstein, Christel A.S. Bergström. Development of a canine artificial colonic mucus model for drug diffusion studies (European Journal of Pharmaceutical Sciences, Vol. 194, 2024)
• Yassir Al-Tikriti, Per Hansson. A small-angle X-ray scattering study of amphiphilic drug self-assemblies in polyacrylate microgels (Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 686, 2024)
• Göran Frenning. Single-particle fabric tensors for assemblies of spherical particles. (Computer Methods in Applied Mechanics and Engineering, Vol. 420, 2024)
• Prosper Emeh, Katarina Breitholtz, Staffan Berg, Charlotta Vedin, Maria Englund, Teresia Uggla, Malin Antonsson, Filipe Nunes, Constanze Hilgendorf, Christel A. S. Bergström, Nigel Davies. Experiences and Translatability of In Vitro and In Vivo Models to Evaluate Caprate as a Permeation Enhancer (Mol. Pharmaceutics, 2024)

2023

• Shakhawath Hossain. Voices in Molecular Pharmaceutics: Meet Dr. Shakhawath Hossain, a Computational Pharmaceutics Expert Seeking to Improve Delivery of Poorly Permeable Molecules. (Mol. Pharmaceutics, 2023)
• Vahid Forooqi Motlaq, Lars Gedda, Katarina Edwards, James Doutch, Magnus Bergström. Spontaneous formation of ultra-small unilamellar vesicles in mixtures of an amphiphilic drug and a phospholipid. (Langmuir, 2023)
• Marcus Wanselius, Yassir Al-Tikriti, Per Hansson. Utilizing a microfluidic platform to investigate drug-eluting beads: Binding and release of amphiphilic antidepressants. (International Journal of Pharmaceutics, Vol. 647, 2023)
• Shakhawath Hossain, Rosita Kneiszlab, Per Larsson. Revealing the interaction between peptide drugs and permeation enhancers in the presence of intestinal bile salts (Nanoscale, 47, 2023)
• Aleksei Kabedev, Christel A. S. Bergström & Per Larsson. Molecular dynamics study on micelle-small molecule interactions: developing a strategy for an extensive comparison. (Journal of Computer-Aided Molecular Design, 2023)
• Dariush Nikjoo, Irès van der Zwaan, Jonas Rudén, Göran Frenning. Engineered microparticles of hyaluronic acid hydrogel for controlled pulmonary release of salbutamol sulphate. (International Journal of Pharmaceutics, Vol. 643, 2023)
• Camilla Eriksson, Sunithi Gunasekera, Taj Muhammad, Mingshu Zhang, Ida Laurén, Sara Mangsbo, Martin Lord, Ulf Göransson. Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies (Chembiochem, 2023)
• Vicky Barmpatsalou. Understanding the gastrointestinal mucus and its impact on drug absorption (Acta Universitatis Upsaliensis, 2023)
• Irès van der Zwaan. Characterisation of an in vitro dissolution method for assessment of novel pulmonary drug delivery systems: With a focus on controlled release systems (Acta Universitatis Upsaliensis, 2023)Rebekkah Hammar, Mikael Sellin, Per Artursson. Epithelial and microbial determinants of colonic drug distribution (European Journal of Pharmaceutical Sciences, Vol. 183, 2023)
• Albin Parrow, Per Larsson, Patrick Augustijns, Christel Bergström. Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs (Molecular Pharmaceutics, Vol. 20, no 1, 2023)
• Marcus Wanselius. Development and characterization of an in vitro method for interaction studies between polymers and pharmaceuticals: Aiding in the development of new drug delivery systems. (Avhandling, Uppsala universitet)
• Ann-Sofie Persson, Göran Alderborn. Tabletability and compactibility of α-lactose monohydrate powders of different particle size. II: predicted relationships (Pharmaceutical development and technology, Vol. 28, no 6, 2023)
• Sohan Sarangi, Anna Simonsson, Göran Frenning. Segregation in inhalable powders: Quantification of the effect of vibration on adhesive mixtures (European Journal of Pharmaceutics and Biopharmaceutics, 2023)
• Göran Frenning. On the thermodynamic consistency of the Drucker–Prager Cap model: Modification of the plastic potential and analysis of unloading (Powder Technology, 2023)
• Aleksei Kabedev, Shakhawath Hossain, Per Larsson. Molecular Dynamics Simulations as a Tool to Understand Drug Solubilization in Pharmaceutical Systems (Chemistry, Molecular Sciences and Chemical Engineering, 2023)
• Benyamin Naranjani, Patrick D. Sinko, Christel A.S. Bergström, Adolf Gogoll, Shakhawath Hossain, Per Larsson. Numerical simulation of peristalsis to study co-localization and intestinal distribution of a macromolecular drug and permeation enhancer (International Journal of Biological Macromolecules, 2023)
• van der Zwaan, G. Frenning. A new modelling approach for dissolution of polydisperse powders. International Journal of Pharmaceutics 633, 122626, (2023)
• S. Sarangi, G. Frenning. Effective friction in adhesive mixtures intended for inhalation: Simulation of oblique impact of adhesive units. Powder Technology 414 118075 (2023)
• Staffan Berg, Teresia Uggla, Malin Antonsson, Sandro Filipe Nunes, Maria Englund, Louise Rosengren, Masoud Fahraj, Xiaoqiu Wu, Rydvikha Govender, Magnus Söderberg, David Janzén, Natalie Van Zuydam, Andreas Hugerth, Anette Larsson, Susanna Abrahmsén-Alami, Bertil Abrahamsson, Nigel Davies, Christel Bergström. Evaluation in pig of an intestinal administration device for oral peptide delivery. Journal of Controlled Release, volume 353, January 2023.

2021-2022

• M. Tofiq, J. Nordström, A. Persson, G. Alderborn. Deciphering the role of granule deformation and fragmentation for the tableting performance of some dry granulated powders, Powder Technol. 409, 117794 (2022).
• G. Frenning. A Voronoi strain-based method for granular materials and continua. Comp. Part. Mech. (early access).
• Vicky Barmpatsalou, Agnes Rodler, Magdalena Jacobson, Eva Marie-Louise Karlsson, Betty Lomstein Pedersen, Christel Bergström. Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs. European Journal of Pharmaceutical Sciences, Volume 181, February 2023.
• Staffan Berg, Helena Edlund, William R. F. Goundry, Christel Bergström, Nigel M. Davies. Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers. International Journal of Pharmaceutics, Volume 628, November 2022.
• S M Mangsbo, IEBT - Whole protein or long peptides in therapeutic vaccination strategies, does it make a difference?, Expert Opinion on Biological Therapy, DOI:10.1080/14712598.2022.2156784.
• van der Zwaan I, Franek F, Fransson R, Tehler U, Frenning G. Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model, Molecular Pharmaceutics, 2022.
• Jacobsen AC, Kabedev A, Sinko PD, Palm JE, Bergström CAS, Teleki A. Intrinsic lipolysis rate for systematic design of lipid-based formulations. Drug Delivery and Translational Research. 2022.
• Marcus Wanselius, Agnes Rodler, Sean S. Searle, Susanna Abrahmsén-Alami, Per Hansson. Responsive Hyaluronic Acid–Ethylacrylamide Microgels Fabricated Using Microfluidics Technique, Gels 2022.
• Göran Frenning. Towards a macroscopically consistent discrete method for granular materials: Delaunay strain-based formulation, Comput. Part. Mech., 2021.
• Jonas Rudén, Göran Frenning, Tobias Bramer, Kyrre Thalberg and Göran Alderborn. Effect of pressure drop on the in vitro dispersion of adhesive mixtures of different blend states for inhalation, International journal of pharmaceutics 617, 121590, 2022.
• Jonas Rudén, Göran Frenning, Tobias Bramer, Kyrre Thalberg and Göran Alderborn. On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients International journal of pharmaceutics X, 3, 100069, 2021.
• Ann-Sofie Persson, Samaneh Pazesh, Göran Alderborn. Tabletability and compactibility of α-lactose monohydrate powders of different particle size. I. Experimental comparison. Pharmaceutical Development and Technology, 2022, Ahead of print.
• Maryam Tofiq, Josefina Nordström, Ann-Sofie Persson and Göran Alderborn. Effect of excipient properties and blend ratio on the compression properties of dry granulated particles prepared from microcrystalline cellulose and lactose. Powder Technology, 399, 117207, 2022.
• Hossain, S. et al. Explicit-pH Coarse-Grained Molecular Dynamics Simulations Enable Insights into Restructuring of Intestinal Colloidal Aggregates with Permeation Enhancers, MDPI Processes, 10, 29, 2022
• Berg, S. et al. Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat, Mol. Pharmaceutics, 19(1), 200-212, 2022
• Berg, S. et al. Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal Instillation Model, Mol. Pharmaceutics, 2022
• Mohamed Eltahir, Ida Laurén, Martin Lord, Aikaterini Chourlia, Leif Dahllund, Anders Olsson, Aljona Saleh, A. Jimmy Ytterberg, Annika Lindqvist, Oskar Andersson, Helena Persson, Sara M. Mangsbo. An Adaptable Antibody-Based Platform for Flexible Synthetic Peptide Delivery Built on Agonistic CD40 Antibodies. Advanced Therapeutics, Published online 2022 May 19 (early view). doi.org: 10.1002/adtp.202200008
• Ida Laurén, Sebastian Havervall, Henry Ng, Martin Lord, Aleksandra Pettke, Nina Greilert-Norin, Lena Gabrielsson, Aikaterini Chourlia, Catarina Amoêdo-Leite, Vijay Sai Josyula, Mohamed Eltahir, Iliana Kerzeli1, August Jernbom Falk, Jonathan Hober, Wanda Christ, Anna Wiberg, My Hedhammar, Hanna Tegel, Joachim Burman, Feifei Xu, Elisa Pin, Anna Månberg, Jonas Klingström, Gustaf Christoffersson, Sophia Hober, Peter Nilsson, Mia Philipson, Pierre Dönnes, Robin Lindsay, Sara Mangsbo, Charlotte Thålin. Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity and symptomatology. Immun Inflamm Dis. 2022, 10, e595.
• Dubbelboer, I.R., Sjögren, E. Physiological based pharmacokinetic and biopharmaceutics modelling of subcutaneously administered compounds – an overview of in silico models. International Journal of Pharmaceutics. 2022, 621,121808
• Y. Al-Tikriti, Microgels as drug delivery vehicles: Loading and release of amphiphilic drugs. Doctoral Thesis, Uppsala University, 2022
• V. Forooqi Motlaq, F.A. Adlmann, V. Agmo Hernández, A. Vorobiev, M. Wolff, L.M. Bergström. Dissolution mechanism of supported phospholipid bilayer in the presence of amphiphilic drug investigated by neutron reflectometry and quartz crystal microbalance with dissipation monitoring. Biochimica et Biophysica Acta (BBA) – Biomembranes, 1864, 183976, 2022.
• Marcus Wanselius, Sean Searle, Agnes Rodler, Maria Tenje, Susanna Abrahmsén-Alamic, Per Hansson. Microfluidics platform for studies of peptide – polyelectrolyte interaction. International Journal of Pharmaceutics, Volume 621, 2022.
• Ilse R.Dubbelboer, Vicky Barmpatsalou, Agnes Rodler, Eva Karlsson, Sandro Filipe Nunes, Johanna Holmberg, Jens Häggström, Christel A.S.Bergström.
  Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties. European Journal of Pharmaceutics and Biopharmaceutics, Volume 173, Pages 92-102, 2022.
• Ilse R.Dubbelboer, Erik Sjögren. Overview of authorized drug products for subcutaneous administration: pharmaceutical, therapeutic, and physicochemical properties. European Journal of Pharmaceutical Sciences. Part of special issue: SI: Personalized Medicines, biopharmaceuticals, precision drug delivery, quality control, 2022.
• Y. Al-Tikriti, P. Hansson. Drug-Induced Phase Separation in Polyelectrolyte Microgels. Gels 2022, 8, 4.
• V. Forooqi Motlaq, M. Ortega-Holmberg, K. Edwards, L. Gedda, J. Lyngsø, J.S. Pedersen, L. M. Bergström. Investigation of the enhanced ability of bile salt surfactants to solubilize phospholipid bilayers and form mixed micelles. Soft Matter, 2021, 17, 7769.
• D Nikjoo, I van der Zwaan, M Brülls, U Tehler, and G Frenning. Hyaluronic acid hydrogels for controlled pulmonary drug delivery—a particle engineering approach. Pharmaceutics, 13: 1878, 2021.
• S Sarangi, K Thalberg, and G Frenning. Effect of carrier size and mechanical properties on adhesive unit stability for inhalation: A numerical study. Powder Technol., 385:230–239, 2021.
• S Sarangi, K Thalberg, and G Frenning. Effect of fine particle shape on the stability and performance of adhesive mixtures intended for inhalation. Powder Technol., 385:299–305, 2021.
• Barmpatsalou et al., Physiological properties, composition and structural profiling of porcine gastrointestinal mucus, Eur J Pharm Biopharm, 169, 156-167, 2021.
• Kneiszl et al., In silico-based experiments on mechanistic interactions between several intestinal permeation enhancers with a lipid bilayer model, Mol Pharmaceutics, 2021.
• Hjalte et al., Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by 1H NMR and All-Atom Molecular Dynamics Simulations, Mol Pharmaceutics, 2022.
• Berg et al., Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat, Mol Pharmaceutics, 2021.
• Berg S, Krause J, Björkbom A, Walter K, Harun S, Granfeldt A, Janzén D, Nunes SF, Antonsson M, Van Zuydam N, Skrtic S, Hugerth A, Weitschies W, Davies N, Abrahamsson B, Bergström CAS. In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery. Journal of Pharmaceutical Sciences. 2021 Jan;110(1):228-238. doi: 10.1016/j.xphs.2020.10.066. Epub 2020 Nov 17.

2020

• Hossain S, Joyce P, Parrow A, Jõemetsa S, Höök F, Larsson P, Bergström CAS. Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers. Mol Pharm. 2020 Sep 22. DOI: 10.1021/acs.molpharmaceut.0c00668. Online ahead of print.PMID: 32960068.
• Sou T, Bergström CAS. Contemporary formulation development for inhaled pharmaceuticals. J Pharm Sci. 2020 Sep 8:S0022-3549(20)30500-1. doi: 10.1016/j.xphs.2020.09.006. Online ahead of print.
• J. Eriksson, H. Thörn, H. Lennernäs, E. Sjögren, Pulmonary drug absorption and systemic exposure in human: predictions using physiologically based biopharmaceutics modeling, In press.
• J. Eriksson, E. Sjögren, H. Lennernäs, H. Thörn, Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption, Aaps Journal, 22 (2020).
• S. Sarangi, K. Thalberg, G. Frenning, Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling, Chemical Engineering Science: X, 6 (2020) 100051.
• J. An, D. Forchheimer, J. Savmarker, M. Brulls, G. Frenning, Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles, Journal of Colloid and Interface Science, 577 (2020) 92-100.
• G. Frenning, I. van der Zwaan, F. Franek, R. Fransson, U. Tehler, Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs, Molecular Pharmaceutics, 17 (2020) 2426-2434.
• P. Larsson, R. Kneiszl, M.E.G. M., MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all‐atom molecular dynamics simulations, J Comp Chem 41 (2020) 1564-1569.
• P. Hansson, Volume Transition and Phase Coexistence in Polyelectrolyte Gels Interacting with Amphiphiles and Proteins, Gels, 6 (2020) 24.
• Y. Al-Tikriti, P. Hansson, Drug-Eluting Polyacrylate Microgels: Loading and Release of Amitriptyline, Journal of Physical Chemistry B, 124 (2020) 2289-2304.
• P. Joyce, S. Jõemetsa, S Isaksson, S Hossain, P Larsson, Bergström C, Höök F. Investigating drug permeation across a lipid membrane supported on mesoporous silica. Angew Chem Int Ed Engl. 2020 Sep 14. doi: 10.1002/anie.202011931. Online ahead of print.PMID: 32926534.
• Edueng, K, Bergström CAS, Gråsjö, J, Mahlin, D. Long-Term Physical (In)Stability of Spray-Dried Amorphous Drugs: Relationship with Glass-Forming Ability and Physiochemical Properties.
• Edueng, K, Mahlin, D, Gråsjö, J, Nylander, O, Thakrani, M, and Bergström, C A S. Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage.
• Hossain, S, Kabedev, A, Parrow, A, Bergström, C, Larsson, P. Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning.

– 2019

• Rudén, J, Frenning, G, Bramer, T, Thalberg, K, An, J and Alderborn G. Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model. Int. J. Pharm. 561 (2019) 148-160.
• Hossain, MS, Berg, S, Bergström, CAS, and Larsson P. Aggregation behaviour of medium chain fatty acids studied by coarse-grained molecular dynamics simulation. AAPS PharmSciTech. 20 (2019) 61.
• Jonsson, H, Alderborn, G, and Frenning, G. Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial compression experiments on single particles. Powder Technol. 345 (2019) 74-81.
• Jonsson, H, Öhman-Mägi, C, Alderborn, G, Isaksson, P, and Frenning, G. Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load. Int. J. Pharm. 559 (2019) 130-137.
• Rudén, J, Frenning, G, Bramer, T, Thalberg, K, and Alderborn G. Relationships between surface coverage ratio and powder mechanics of binary adhesive mixtures for dry powder inhalers. Int. J. Pharm. 541 (2018) 143-156.
• Nordström J, Alderborn, G, and Frenning, G. Compressibility and tablet-forming ability of bimodal granule mixtures: Experiments and DEM simulations. Int. J. Pharm. 540 (2018) 120-131.
• Eriksson, J, Sjögren, E, Thörn, H, Rubin, Bäckman, P, and Lennernäs, H. Pulmonary absorption – estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis. Eur. J. Pharm. Biopharm. 124 (2018) 1-12.