Development of A Novel Pulmonary Controlled Release Drug Delivery System (Completed project)
Developing a novel controlled release drug delivery systems for the lungs.
Details
- Funder: Vinnova
Research scientist: Irès van der Zwaan, MSc
Principal Investigator: Professor Göran Frenning, Department of Pharmaceutical Biosciences, Uppsala University
Scientific and industrial context. Controlled release formulations for drug delivery to the lung would facilitate new therapeutic opportunities for the inhalation area. However, the area is challenging and there are today no controlled-release formulations available in the market. Lack of these controlled delivery systems limits the development of novel pulmonary therapies.
Aim. The aim of the project is to create new controlled release systems for drug delivery in the lung by surveying and evaluating the dissolution of several promising controlled release options as well as novel systems. Different methods will be used to evaluate existing and novel drug delivery systems such as deposition of inhalation powders using a modified Andersen cascade impactor and dissolution in a Transwell system, a μDiss Profiler and single particle approach.
Outcome. Novel controlled release drug delivery systems for the lungs.