Particle Dynamics and Multiscale Modelling of Adhesive Mixtures for Inhaled Medicines (Completed project)

Research Scientist: Sohan Sarangi, MSc
Principal Investigator: Professor Göran Frenning, Department of Pharmaceutical Biosciences, Uppsala University

Scientific and Industrial Context. Adhesive mixtures in which micronized particles are attached to considerably larger carrier particles, are often used to overcome the cohesiveness resulting from the small particle size needed for pulmonary drug delivery. Formulation and handling of adhesive mixtures is an unexplored regime which is of both scientific and industrial importance.

Aim. The aim of this project is to study the interaction and effective mechanical properties between the drug and carrier particles and their aggregates using a particle based modelling approach and validating the same through experiments.

Outcome. The proposed research is expected to make a significant contribution to the knowledge of adhesive mixtures during general handling and transportation. It would also address generic issue on powder flow and coupling the same with experiments would provide a deeper scientific insight into the problem.