Investigation of adhesive layer microstructure of adhesive mixtures using Small Angle X-ray Scattering (Completed project)
Increasing our knowledge on how the information of adhesive layer microstructures can be used to understand the dispersibility of adhesive mixtures during inhalation of a pulmonary drug.
Details
- Funder: Vinnova
Research scientist: Ann-Sofie Persson, Researcher
Principal Investigator: Professor Göran Alderborn, Department of Pharmaceutical Biosciences, Uppsala University
Scientific and industrial context. Small Angle X-ray Scattering is a technique whose capacity regarding pharmaceutical powder materials is yet to be completely identified. Within the framework of this project, tests will be conducted to clearify whether it is applicable for measuring inter-particulate pores in powder beds.
Aim. The aim of the project is four-fold with the three initial aims focusing on if small angle x-ray scattering technique can be used to study:
- Porosity (microstructure) of solid powders
- Size and shape of inter-particulate pores (voids) in powder beds
- Adhesive layer microstructure of adhesive mixtures
Outcome. Improved knowledge on how the information of adhesive layer microstructures can be used to understand the dispersibility of adhesive mixtures during inhalation of a pulmonary drug.