Michael Williams
Researcher at Department of Surgical Sciences; Functional Pharmacology and neuroscience
- E-mail:
- michael.williams@uu.se
- Visiting address:
- BMC, Husargatan 3
751 24 Uppsala - Postal address:
- Kirurgiska vetenskaper, Box 593
751 24 Uppsala
- Academic merits:
- PhD
Short presentation
The current aim of my research is to employ the model organism Drosophila melanogaster to evaluate the physiological costs of perturbing genes linked to human obesity. Many of the genes linked with obesity seem to be involved in regulating the development or function of the nervous system. I aim to understand specific functional roles of homologous obesity-linked genes, in the central nervous system, at the organismal, cellular and molecular levels.
Biography
Education
Doctor of Philosophy, Molecular Genetics, University of Notre Dame, Notre
Dame, Indiana, 46556, USA. Received: 1994-1999
Current lab members
Postdoctoral assistants
Dr Lyle Weimerslage (2014-present) Metabolic interactions of environmental toxins in Drosophila.
Dr Maryam Nikpour (2016-present) Control of metabolism and feeding bheaviour in Drosophila.
PhD students
Hao Cao: (2015-present) Project: Metabolic interactions of environmental toxins in Drosophila. Funded by Chinese Research Council.
Research assistant
Giulia Maestri (2015-present)

Publications
Recent publications
Off-target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
Part of British Journal of Pharmacology, p. 3799-3818, 2024
- DOI for Off-target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
- Download full text (pdf) of Off-target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
Part of Science of the Total Environment, p. 177472, 2024
Part of Scientific Reports, 2024
- DOI for Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes
- Download full text (pdf) of Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes
Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster
Part of Biology, 2023
- DOI for Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster
- Download full text (pdf) of Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster
Part of Biomedicines, 2023
- DOI for Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors: High Evolutionary Conservation of DPP4
- Download full text (pdf) of Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors: High Evolutionary Conservation of DPP4
All publications
Articles in journal
Off-target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
Part of British Journal of Pharmacology, p. 3799-3818, 2024
- DOI for Off-target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
- Download full text (pdf) of Off-target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
Part of Science of the Total Environment, p. 177472, 2024
Part of Scientific Reports, 2024
- DOI for Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes
- Download full text (pdf) of Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes
Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster
Part of Biology, 2023
- DOI for Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster
- Download full text (pdf) of Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster
Part of Biomedicines, 2023
- DOI for Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors: High Evolutionary Conservation of DPP4
- Download full text (pdf) of Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors: High Evolutionary Conservation of DPP4
Part of Biomedicines, 2023
- DOI for Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis
- Download full text (pdf) of Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis
The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila
Part of Pharmaceuticals, 2022
- DOI for The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila
- Download full text (pdf) of The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila
The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms
Part of Cells, 2022
- DOI for The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms
- Download full text (pdf) of The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms
Part of Molecules, 2022
- DOI for Enhanced Toxicity of Bisphenols Together with UV Filters in Water: Identification of Synergy and Antagonism in Three-Component Mixtures
- Download full text (pdf) of Enhanced Toxicity of Bisphenols Together with UV Filters in Water: Identification of Synergy and Antagonism in Three-Component Mixtures
Part of Cells, 2022
- DOI for Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes
- Download full text (pdf) of Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes
Part of Membranes, 2021
- DOI for Multidrug Resistance Like Protein 1 Activity in Malpighian Tubules Regulates Lipid Homeostasis in Drosophila
- Download full text (pdf) of Multidrug Resistance Like Protein 1 Activity in Malpighian Tubules Regulates Lipid Homeostasis in Drosophila
Part of Insects, 2021
- DOI for The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster
- Download full text (pdf) of The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster
Part of Frontiers in Bioscience-Landmark, p. 1453-1463, 2021
- DOI for Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia
- Download full text (pdf) of Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia
Part of Frontiers in Neuroscience, 2021
- DOI for The Drosophila melanogaster Levodopa-Induced Depression Model Exhibits Negative Geotaxis Deficits and Differential Gene Expression in Males and Females
- Download full text (pdf) of The Drosophila melanogaster Levodopa-Induced Depression Model Exhibits Negative Geotaxis Deficits and Differential Gene Expression in Males and Females
Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
Part of Science of the Total Environment, 2021
- DOI for Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
- Download full text (pdf) of Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
Part of Science of the Total Environment, 2021
Part of Cannabis and cannabinoid research, p. 119-136, 2021
Part of International Journal of Molecular Sciences, 2021
- DOI for Integrating Statistical and Machine-Learning Approach for Meta-Analysis of Bisphenol A-Exposure Datasets Reveals Effects on Mouse Gene Expression within Pathways of Apoptosis and Cell Survival
- Download full text (pdf) of Integrating Statistical and Machine-Learning Approach for Meta-Analysis of Bisphenol A-Exposure Datasets Reveals Effects on Mouse Gene Expression within Pathways of Apoptosis and Cell Survival
The Cognitive Effects of Statins are Modified by Age
Part of Scientific Reports, 2020
- DOI for The Cognitive Effects of Statins are Modified by Age
- Download full text (pdf) of The Cognitive Effects of Statins are Modified by Age
Part of Frontiers in Cell and Developmental Biology, 2020
- DOI for CG4928 is vital for renal function in fruit flies and membrane potential in cells: A first in-depth characterization of the putative Solute Carrier UNC93A
- Download full text (pdf) of CG4928 is vital for renal function in fruit flies and membrane potential in cells: A first in-depth characterization of the putative Solute Carrier UNC93A
Part of Environmental Science and Pollution Research, p. 25261-25270, 2020
- DOI for Exposure to the environmental pollutant bisphenol A diglycidyl ether (BADGE) causes cell over-proliferation in Drosophila
- Download full text (pdf) of Exposure to the environmental pollutant bisphenol A diglycidyl ether (BADGE) causes cell over-proliferation in Drosophila
Identification of reference markers for characterizing honey bee (Apis mellifera) hemocyte classes
Part of Developmental and Comparative Immunology, 2020
- DOI for Identification of reference markers for characterizing honey bee (Apis mellifera) hemocyte classes
- Download full text (pdf) of Identification of reference markers for characterizing honey bee (Apis mellifera) hemocyte classes
CCAP regulates feeding behavior via the NPF pathway in Drosophila adults
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 7401-7408, 2020
Part of Translational Psychiatry, 2019
- DOI for Evidence that genes involved in hedgehog signaling are associated with both bipolar disorder and high BMI
- Download full text (pdf) of Evidence that genes involved in hedgehog signaling are associated with both bipolar disorder and high BMI
Part of Zebrafish, 2018
Genes encoding cuticular proteins are components of the Nimrod gene cluster in Drosophila
Part of Insect Biochemistry and Molecular Biology, p. 45-54, 2017
Part of Translational Psychiatry, 2017
- DOI for A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score
- Download full text (pdf) of A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score
Genetical Genomics of Behavior: A Novel Chicken Genomic Model for Anxiety Behavior
Part of Genetics, p. 327-+, 2016
Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies
Part of Frontiers in Aging Neuroscience, 2016
- DOI for Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies
- Download full text (pdf) of Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies
Part of Basic & Clinical Pharmacology & Toxicology, p. 309-316, 2016
The Drosophila ETV5 homologue Ets96B: Molecular link between obesity and bipolar disorder
Part of PLOS Genetics, 2016
- DOI for The Drosophila ETV5 homologue Ets96B: Molecular link between obesity and bipolar disorder
- Download full text (pdf) of The Drosophila ETV5 homologue Ets96B: Molecular link between obesity and bipolar disorder
Part of PLOS ONE, 2016
- DOI for The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster
- Download full text (pdf) of The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster
Part of Endocrinology, p. 2309-2321, 2016
The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling
Part of Journal of Endocrinology, p. 233-243, 2016
Implication of coronin 7 in body weight regulation in humans, mice and flies
Part of BMC Neuroscience, 2015
- DOI for Implication of coronin 7 in body weight regulation in humans, mice and flies
- Download full text (pdf) of Implication of coronin 7 in body weight regulation in humans, mice and flies
The obesity-linked Nudt3 Drosophila homolog Aps is associated with insulin signalling
Part of Molecular Endocrinology, p. 1303-1319, 2015
Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families
Part of Molecular Phylogenetics and Evolution, p. 27-40, 2015
Part of BMC Evolutionary Biology, 2014
- DOI for The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals
- Download full text (pdf) of The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals
Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling
Part of Frontiers in Endocrinology, p. 219, 2014
Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster
Part of PLOS Genetics, 2014
- DOI for Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster
- Download full text (pdf) of Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster
Part of PLOS ONE, 2014
- DOI for Drosophila Insulin-Producing Cells Are Differentially Modulated by Serotonin and Octopamine Receptors and Affect Social Behavior
- Download full text (pdf) of Drosophila Insulin-Producing Cells Are Differentially Modulated by Serotonin and Octopamine Receptors and Affect Social Behavior
The Drosophila Kctd-family homologue Kctd12-like modulates male aggression and mating behaviour
Part of European Journal of Neuroscience, p. 2513-2526, 2014
The Drosophila Small GTPase Rac2 is Required for Normal Feeding and Mating Behaviour.
Part of Behavior Genetics, p. 155-64, 2014
Exposure to Bisphenol A Affects Lipid Metabolism in Drosophila melanogaster
Part of Basic & Clinical Pharmacology & Toxicology, p. 414-420, 2014
Part of Genetics, p. 349-362, 2014
Part of Journal of Systematics and Evolution, p. 664-670, 2013
Real-time analysis of Drosophila post-embryonic haemocyte behaviour
Part of PLOS ONE, 2012
- DOI for Real-time analysis of Drosophila post-embryonic haemocyte behaviour
- Download full text (pdf) of Real-time analysis of Drosophila post-embryonic haemocyte behaviour
A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response
Part of Immunogenetics, p. 155-161, 2012
Part of Developmental and Comparative Immunology, p. 160-168, 2012
Part of Methods in molecular biology (Clifton, N.J.), p. 359-67, 2012
Part of Small GTPases, p. 201, 2012
The Rho-family GTPase Rac1 regulates integrin localization in Drosophila immunosurveillance cells
Part of PLOS ONE, 2011
Drosophila cellular immunity: a story of migration and adhesion
Part of Journal of Cell Science, p. 1373-1382, 2011
Articles, review/survey
Part of Journal of genetics and genomics = Yi chuan xue bao, p. 1-12, 2022
Part of Critical reviews in environmental science and technology, p. 4094-4112, 2022
- DOI for The potential interaction of environmental pollutants and circadian rhythm regulations that may cause leukemia
- Download full text (pdf) of The potential interaction of environmental pollutants and circadian rhythm regulations that may cause leukemia
Part of Cell & Bioscience, 2022
- DOI for The regulatory role of AP-2 beta in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential
- Download full text (pdf) of The regulatory role of AP-2 beta in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential
Role of the synergistic interactions of environmental pollutants in the development of cancer
Part of GeoHealth, 2022
- DOI for Role of the synergistic interactions of environmental pollutants in the development of cancer
- Download full text (pdf) of Role of the synergistic interactions of environmental pollutants in the development of cancer
Part of Neuroscience and Biobehavioral Reviews, p. 1-12, 2021
- DOI for Rodent and fly models in behavioral neuroscience: An evaluation of methodological advances, comparative research, and future perspectives
- Download full text (pdf) of Rodent and fly models in behavioral neuroscience: An evaluation of methodological advances, comparative research, and future perspectives
The Synaptic Scaling Literature: A Systematic Review of Methodologies and Quality of Reporting
Part of Frontiers in Cellular Neuroscience, 2020
- DOI for The Synaptic Scaling Literature: A Systematic Review of Methodologies and Quality of Reporting
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Neural Cotransmission in Spinal Circuits Governing Locomotion
Part of TINS - Trends in Neurosciences, p. 540-550, 2018
What model organisms and interactomics can reveal about the genetics of human obesity
Part of Cellular and Molecular Life Sciences (CMLS), p. 3819-3834, 2012